
                                SEQUENCE LISTING

<110> AVI BioPharma, Inc.
      Hanson, Gunnar, J.
      Rudolph, Alexander, Charles
      Cai, Bao, Zhong
      Zhou, Ming
      Weller, Dwight, D.

<120> OLIGONUCLEOTIDE ANALOGUES HAVING
  MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
 

<130> 120178.487PC

<140> PCT                  
<141> 2011-05-27  

<150> US 61/349,783       
<151> 2010-05-28  

<150> US 61/361,878       
<151> 2010-07-06 

<150> US 61/386,428       
<151> 2010-09-24 
  
<160> 88

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 1
cggtccacgt agactaacaa ct                                          22

<210> 2
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 2
gaagttcaca cagataaact tct                                         23

<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 3
cggttagaag actcatcttt                                             20

<210> 4
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 4
tttcgacatc ggttagaaga ctcat                                       25

<210> 5
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 5
gagacgccat gatgtggatg tc                                          22

<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 6
gaaacacgga cacccaaagt agt                                         23

<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 7
tcccagcgtc aatatgctgt tt                                          22

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 8
gcctaggatc cacggtgcgc                                             20

<210> 9
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 9
gggacaaaat ggatcccatt attaatggaa attctgctaa                       40

<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 10
taatgggatc cattttgtcc c                                           21

<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 11
aataatggga tccattttgt ccc                                         23

<210> 12
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 12
cattaataat gggatccatt ttgtccc                                     27

<210> 13
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 13
gaatttccat taataatggg atccattttg                                  30

<210> 14
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 14
cagaatttcc attaataatg ggatccatt                                   29

<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 15
ggccaaacct cggcttacct gaaat                                       25

<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 16
ggccaaacct cggcttacct gaaat                                       25

<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 17
gctattacct taacccag                                               18

<210> 18
<211> 52
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 18
gaaaaaagat tatattgatt ttaaaatcat gcaaaaactg caactctgtg tt         52

<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 19
catacatttg cagtttttgc atcat                                       25

<210> 20
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 20
tcatttttaa aaatcagcac aatctt                                      26

<210> 21
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 21
cagtttttgc atcattttta aaaatc                                      26

<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 22
gatctgtcaa atcgcctgca ggtaa                                       25

<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 23
aaactgttca gcttctgtta gccac                                       25

<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 24
ttgtgtcttt ctgagaaact gttca                                       25

<210> 25
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 25
ctgacaacag tttgccgctg cccaa                                       25

<210> 26
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 26
ccaatgccat cctggagttc ctgtaa                                      26

<210> 27
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 27
cattcaatgt tctgacaaca gtttgccgct                                  30

<210> 28
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 28
cttacaggct ccaatagtgg tcagt                                       25

<210> 29
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 29
ccactcagag ctcagatctt ctaacttcc                                   29

<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 30
gggatccagt atacttacag gctcc                                       25

<210> 31
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 31
acatcaagga agatggcatt tctagtttgg                                  30

<210> 32
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 32
ctccaacatc aaggaagatg gcatttctag                                  30

<210> 33
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 33
gagcaggtac ctccaacatc aaggaa                                      26

<210> 34
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 34
ctgaaggtgt tcttgtactt catcc                                       25

<210> 35
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 35
tgttcttgta cttcatccca ctgattctga                                  30

<210> 36
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 36
ctttcataat gctggcag                                               18

<210> 37
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 37
cataatgctg gcag                                                   14

<210> 38
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 38
gctggcag                                                          8

<210> 39
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 39
cagcagcag                                                         9

<210> 40
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 40
cagcagcagc ag                                                     12

<210> 41
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 41
cagcagcagc agcag                                                  15

<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 42
cagcagcagc agcagcag                                               18

<210> 43
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 43
agcagcagc                                                         9

<210> 44
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 44
agcagcagca gc                                                     12

<210> 45
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 45
agcagcagca gcagc                                                  15

<210> 46
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 46
agcagcagca gcagcagc                                               18

<210> 47
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 47
gcagcagca                                                         9

<210> 48
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 48
gcagcagcag ca                                                     12

<210> 49
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 49
gcagcagcag cagca                                                  15

<210> 50
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 50
gcagcagcag cagcagca                                               18

<210> 51
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 51
agcagcagca gcagcagcag cagca                                       25

<210> 52
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 52
cagcagcagc agcagcagca gcagc                                       25

<210> 53
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 53
caggcaggc                                                         9

<210> 54
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 54
caggcaggca gg                                                     12

<210> 55
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense oligomer

<400> 55
caggcaggca ggcaggcagg cagg                                        24

<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 56
Arg Arg Arg Gln Arg Arg Lys Lys Arg
 1               5                  


<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 57
Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  


<210> 58
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 58
Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe
 1               5                  10      


<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 59
Arg Arg Arg Arg Arg Phe Phe Arg Arg Arg Arg
 1               5                  10      


<210> 60
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 60
Arg Arg Arg Arg
 1              


<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 61
Arg Arg Arg Arg Arg
 1               5  


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 62
Arg Arg Arg Arg Arg Arg
 1               5      


<210> 63
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 63
Arg Arg Arg Arg Arg Arg Arg
 1               5          


<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 64
Arg Arg Arg Arg Arg Arg Arg Arg
 1               5              


<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 65
Arg Arg Arg Arg Arg Arg Arg Arg Arg
 1               5                  


<210> 66
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11
<223> Acp

<400> 66
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
 1               5                  10          


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 14
<223> Acp

<400> 67
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
 1               5                  10                  15  


<210> 68
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 8
<223> Acp

<220> 
<221> MOD_RES        
<222> 5, 11
<223> bAla

<400> 68
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
 1               5                  10          


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 69
Arg Ala Arg Arg Ala Arg Arg Ala Arg Arg Ala Arg Phe Phe Cys
 1               5                  10                  15  


<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 70
Arg Gly Arg Arg Gly Arg Arg Gly Arg Arg Gly Arg Phe Phe Cys
 1               5                  10                  15  


<210> 71
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 71
Arg Arg Arg Gln Arg Arg Lys Lys Arg Cys
 1               5                  10  


<210> 72
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 72
Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe Cys
 1               5                  10          


<210> 73
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 3, 6, 9, 12
<223> Acp

<220> 
<221> MOD_RES        
<222> 13
<223> bAla

<400> 73
Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Xaa
 1               5                  10              


<210> 74
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 14
<223> bAla

<400> 74
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa
 1               5                  10                  


<210> 75
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 1, 4, 7, 10, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 14
<223> bAla

<400> 75
Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Xaa
 1               5                  10                  


<210> 76
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 4, 6, 8, 10, 12
<223> Acp

<220> 
<221> MOD_RES        
<222> 13
<223> bAla

<400> 76
Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Xaa
 1               5                  10              


<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 4, 6, 8, 10, 12, 14
<223> Acp

<220> 
<221> MOD_RES        
<222> 15
<223> bAla

<400> 77
Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Xaa
 1               5                  10                  15  


<210> 78
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 14, 16
<223> Acp

<220> 
<221> MOD_RES        
<222> 17
<223> bAla

<400> 78
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa
 1               5                  10                  15      
Xaa
    


<210> 79
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 8, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 5, 11, 14
<223> bAla

<400> 79
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa
 1               5                  10                  


<210> 80
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 80
Arg Arg Arg Arg Arg Arg Gly
 1               5          


<210> 81
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 81
Arg Arg Arg Arg Arg Arg Arg Gly
 1               5              


<210> 82
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 82
Arg Arg Arg Arg Arg Arg Arg Arg Gly
 1               5                  


<210> 83
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 83
Arg Arg Arg Arg Arg Gly Arg Arg Arg Arg Gly
 1               5                  10      


<210> 84
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 84
Arg Arg Arg Arg Arg Phe Phe Arg Arg Arg Arg Gly
 1               5                  10          


<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 85
Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly
 1               5                  10  


<210> 86
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 86
Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly
 1               5                  10  


<210> 87
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> VARIANT        
<222> 2, 8
<223> Xaa = Ala,  beta-alanine, Val, Leu, Ile, Ser, Gly,
      Thr, Phe, Trp, and 6-aminohexanoic acid

<400> 87
Arg Xaa Arg Arg Gly Gly Arg Xaa Arg Arg Gly Gly
 1               5                  10          


<210> 88
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> VARIANT        
<222> 2, 6, 8, 12
<223> Xaa = Ala,  beta-alanine, Val, Leu, Ile, Ser, Gly,
      Thr, Phe, Trp, and 6-aminohexanoic acid

<400> 88
Arg Xaa Arg Arg Arg Xaa Arg Xaa Arg Arg Arg Xaa Gly
 1               5                  10              

