                         SEQUENCE LISTING

<110>  OPKO CURNA LLC
 
<120>  TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED 
       DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA

<130>  MSRA

<150>  US61/348650
<151>  2010-05-26

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1372
<212>  DNA
<213>  Homo sapiens

<300>
<308>  NM_001135670.1
<309>  2011-04-09
<313>  (1)..(1372)

<400>  1
cagccggtac ggccccgggt ttgggcaacc tcgattacgg gcggcctcca gccccgccag       60

cagcgccccg cgcccgcccg cccgcgcccc tgccgccccc cggttccggc cgcggacccc      120

actctctgcc gttccggctg cggctccgct gccggtagcg ccgtcccccg ggaccaccct      180

tcggctggcg ccctcccatg ctctcggcca cccggagggc ttgccagctc ctcctcctcc      240

acagcctctt tcccgtcccg aggatgggca actcggcctc gaacatcgtc agcccccagg      300

aggccttgcc gggccggaag gaacagaccc ctgtagcggc caaacatcat gtcaatggca      360

acagaacagt cgaacctttc ccagagggaa cacagatggc tgtatttgaa aaaactggcc      420

atgcagaagt cgtccgagtg gtgtaccagc cagaacacat gagttttgag gaactgctca      480

aggtcttctg ggagaatcac gacccgaccc aaggtatgcg ccaggggaac gaccatggca      540

ctcagtaccg ctcggccatc tacccgacct ctgccaagca aatggaggca gccctgagct      600

ccaaagagaa ctaccaaaag gttctttcag agcacggctt cggccccatc actaccgaca      660

tccgggaggg acagactttc tactatgcgg aagactacca ccagcagtac ctgagcaaga      720

accccaatgg ctactgcggc cttgggggca ccggcgtgtc ctgcccagtg ggtattaaaa      780

aataattgct ccccacatgg tgggcctttg aggttccagt aaaaatgctt tcaacaaatt      840

gggcaatgct tgtgtgattc acaatcgtgg catttaaagt gcacaaagta caaaggaatt      900

tatacagatt gggtttaccg aagtataatc tataggaggc gcgatggcaa gttgataaaa      960

tgtgacttat ctcctaataa gttatggtgg gagtggagct gtgcagtttc ctgtgtcttc     1020

tggggtctga gtgaagatag cagggatgct gtgttcaccc ttcttggtag aagctaaggt     1080

gtgagctggg aggttgctgg acaggatggg ggaccccaga agtcctttat ctgtgctctc     1140

tgcccgccag tgccttacaa tttgcaaacg tgtatagcct cagtgactca ttcgctgaaa     1200

tccttcgctt taccaaatct agacatacat aaggggcttt ctctcccttt tcagccctct     1260

ctgtgcagag aaaagatgtg agtccgcttg atgaattcta atgctttgct tagagctatg     1320

agaaatgttt gttttaataa aaacctacag tccaataatg ccaaaaaaaa aa             1372


<210>  2
<211>  3774
<212>  DNA
<213>  Homo sapiens

<400>  2
tctcgggacg aagttctcgg acagagaaca agtgcgctcc tgtcgtacga agtacgtgaa       60

gctgcagagg ccaaaaaaca cgccgagccc ttggggatgc ggtttgattt taaagttgct      120

gccgtgtcgc cccgacttcg cagtttagca gtgcccagta agatagaaga ggacctgcct      180

tgcagccagc tagactgtca gtttttattg gagacattgt catgacggcc atcagaaggg      240

ttgctattcg tccaaagtga aaactaagca cagttctcaa aatgcgcgga atagggaaga      300

tgaattcaat attaagttat gtatttacaa acatatttaa gcccattttg cagcggccaa      360

aatacgggag caaggcacca acagcaccat taaggcagtg taggtggact taatggtggt      420

gttgtattat tcttgtttct caaatcatag gagatgacat ttgttcctgt gacattctca      480

aactaaatgt aaagtggttg gagcgaggtg agtgacttgg gagttcatct gtgtgagatt      540

ttggcttaac acatgttctg ccaaaatggg caggtcgtct cagatgaggg agggaacttc      600

agattagcac ccacagaaag gaggctttca cccagcttct tgcatggatt tagttaccac      660

tttgttttca tgtggtctgg actgtaagga gggcaggagg cttagcagtg ctatagtgta      720

gaatgaggtg tgttgccagg catacaacac taaaaaggct ctagctttga ttttgtaatt      780

tgtatttccc ctggacaaaa tgatacctaa actgtttgtt attgctatga ggctatacca      840

agtcggttcc acaggccttt catgaaaaca cccccaggag tcccttctag gcttgcgaag      900

gcctggtcac tattaagggt ctgaaaaaat agtcattctg tcaaagacaa tattttgtgt      960

ttttcagtta cttctttttg atacatactg atttgtctgt gttttgtggt tgattgtatg     1020

aagtttcaca tgctagaaat actctgcaac taagagctga agaatgttta gtgtgaagaa     1080

ataacttact tggcatgatg gctcactcct gtaatcccaa cactttgaga ggctgaggca     1140

ggaggattgc tggaggccag gagtttgaga cgccatcttt accaaaaaaa aaaaaaaaaa     1200

aggtatttaa gtagttgggc atggtggtgt ggtagcgcac acctgtggtc ccaactactt     1260

gggaggctgc accaggagga acgctggagc cagagaggta gaggctgcag tgagctatga     1320

tcacactgct gtgctccagc ccgggcaaca gagcaagacc ttgtctcaaa aaaaaaaaat     1380

taattttgat gttaaatgaa aaagtaaaac aaatgcagtg tgcgtgtata catgtagtat     1440

atatgaaaat gcatgtactc ccagttgcac agccactgaa caattcgaaa aaaatgcaat     1500

tttttttgtt cagaatagtg ggattctact gcttttcatt gtctttaaac tgttttaagt     1560

gttctgtatt gttacaacgt tctcgagtat tccaatggct gttactttta taattataaa     1620

agaataagca tttttaaaga acagatatat cttatttcaa aaacaagggt ttttcgttta     1680

ccagaatagc tgcaagaaaa gttatattag tttctttggt gttttgagga aagaattgaa     1740

catttttgcc ttcagtggtg cctttttcac cactaggact tccttttctt cagacattcc     1800

ccctaatcca gcggtccccc acctttttgg caccgtggac gagtttcgtg gaagacagtt     1860

tttttccaca gatggggaag gggagatggg ggatggtttc ggggtgaaac tgttccacct     1920

cagatcatca ggcattagtt agcttctcat gaggtgtgtg cagcctagat ccctcacatg     1980

cacagttcac gatagggttt gtcctctgat gagaatctaa tgtcgctgtt gatctgacag     2040

ccacatctaa cttgggaagg tgggagatga ggttctcttg cggagtgact atagatacaa     2100

ctaatacttg gatatttggc agttctaata ataaaacagg aatgttcttt ggacaactgt     2160

gacacaatct actcctctgg cccctcaaat atccatggat acccttgtga cacatagaac     2220

acaccctgtt tgaagagaga aaacccagca ttctaagcag ttactgcatc cagctcagcg     2280

tccatgatct aaagatgtaa cagtccctta caagtctgat ataactcctc atggtccaat     2340

gacctacaga gtaaattatg ttatttattc ccctttctct tccccacaca gccagtatgc     2400

agtggtgaag tagggcacga aaactaattt ggaagaagag tgaggacaaa atagtagttc     2460

tttgtctaag cgaatgtgaa gagcagatta gactacaaag gtaatgaagt aaattcttgg     2520

ttagacccca gttctgtttt ccaggaggaa ctctggtttg ttgcatccaa aggtactgtc     2580

tttacccatt gggaggttct tacccatgat ctatgattcc atctgaaggg catgctaaag     2640

agtgtgctcc atgagaggct acacatcttt ttatatccag tttcttactg gtgcgctttt     2700

gagggactgt gggttacttt agtagggtca gatagacaca ggcattggca agctaggctt     2760

aatagcttct ttgtcaattc aatttttaaa agataccgaa tggatttctt atctgtttgt     2820

tccttgtata gttcctttta caaataacca cagatagaga tctcaattag tcatatttct     2880

tatgcctaac tactcttcat ttttatttac gagactctct catatctcct gtacctacta     2940

acttagtggc tatatgcttg cacccagcaa aaacagcagt catggttagg aaggcagtgc     3000

ccttaatatg acctctattg cttgtctggg ttccactgtc cagcagagaa cactttgctg     3060

atggcctttg agaagtgcct tgggtcacag ttttatctta cactgtcaga agtgtaatag     3120

cttttggctt tatcagaact agaaggcttg aaatcaccac tcagtcaatt tgtattgcag     3180

actacaggca gagaactcca tcttagtatg actttatttc cttccagctc tgttaacaaa     3240

atgactagtt tttacctgag ttcatctttc tcaaagtact ttgctaaaga gacaggaaga     3300

aggcagtact gtctcactga cccagagatt cactcccaac cattttccct gctactacag     3360

attcaaagag caggtagtct gcctgctaag gtactgagtt gacaatttta tcaaatgtct     3420

tgtggcgggg gaaaaaaaaa aggaggggct tggtcaccag cttttcacct gtaatacctg     3480

tgctgcctgt cagttaatta ataccacata atttaggtta atgtcatggt ctctacagaa     3540

aatctggagc taatactggt ttagcaacat tgcagctaca aaatctatat gcaaaaatcg     3600

tatttctata agacaaaata atggaaatca aaattttaaa aatactactt atttattaac     3660

atcaaaaata tttaaaattt gtatctgact gaagatatgt tagacctgca catcaaaacc     3720

gcaaaacatt gctaagagaa atgtaaaaga cctaaataaa tgtggagcta tacc           3774


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Antisense oligonucleotide

<400>  3
actcacctcg ctccaaccac t                                                 21


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  4
ctaccacacc accatgccca                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
acctcatctc ccaccttccc a                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
ctgccttctt cctgtctctt                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  7
ttgtcctcac tcttcttcca                                                   20


<210>  8
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  8
mgmumcmctc amctcmutcm utcmcaaamu mumamg                                 36


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  9
mumumgtcmc tcamctmctt mcttmcmcma                                        30


