                         SEQUENCE LISTING

<110>  Mind-NRG SA
 
<120>  Neuregulin isoforms, neuregulin polypeptides and uses thereof

<130>  MINDN.0033 WO

<150>  US 61/349,451
<151>  2010-05-28

<160>  160   

<170>  PatentIn version 3.5

<210>  1
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     


Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         


Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             


Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 


Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 


Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     


Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         


Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             


Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 


Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 


Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     


Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         


Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             


Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 


Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 


Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     


Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         


Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             


Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 


Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 


Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     


Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         


Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             


Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 


Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 


Asp Pro Ile Ala Val 
                645 


<210>  2
<211>  364
<212>  PRT
<213>  Mus musculus

<400>  2

Met Pro His Pro Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser Asn Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Val Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Ile Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ser Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Ile Ser Asn His Ala Tyr 
        355                 360                 


<210>  3
<211>  363
<212>  PRT
<213>  Mus musculus

<400>  3

Met Pro His Ser Tyr Pro Ala Leu Ser Ala Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala Leu Arg Ile Val Thr Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Val Gly Ser Met Ala Lys Arg Leu Ser Gln Ile Gly 
        35                  40                  45              


Val Glu Asn Thr Glu Glu Asn Arg Arg Leu Tyr Arg Gln Val Leu Phe 
    50                  55                  60                  


Ser Ala Asp Asp Arg Val Lys Lys Cys Ile Gly Gly Val Ile Phe Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Asp Asp Asn Gly Val Pro Phe Val Arg 
                85                  90                  95      


Thr Ile Gln Asp Lys Gly Ile Leu Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asp Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Leu Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Ser Asp Arg Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Leu Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Pro Ile Lys Tyr Ser Pro Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Pro Gly Val Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Leu Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Arg Cys Pro Leu Pro Arg Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Asn Ala Trp Arg Gly Gln Arg Asp Asn 
305                 310                 315                 320 


Ala Gly Ala Ala Thr Glu Glu Phe Ile Lys Arg Ala Glu Met Asn Gly 
                325                 330                 335     


Leu Ala Ala Gln Gly Arg Tyr Glu Gly Ser Gly Asp Gly Gly Ala Ala 
            340                 345                 350         


Ala Gln Ser Leu Tyr Ile Ala Asn His Ala Tyr 
        355                 360             


<210>  4
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Pro Thr Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Lys Cys Leu Gly Glu Leu Ile Cys Thr Leu Asn Ala Ala 
            20                  25                  30          


Asn Val Pro Ala Gly Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Leu Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ser His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Asn Asp Gly Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210>  5
<211>  333
<212>  PRT
<213>  Mus musculus

<400>  5

Met Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly His Leu Val 
1               5                   10                  15      


Thr Arg Ala Ala Ile Cys Ser Gly Lys Val Glu Ile Val Ala Ile Asn 
            20                  25                  30          


Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln Tyr Asp 
        35                  40                  45              


Ser Thr His Gly Lys Phe Asn Gly Thr Val Lys Ala Glu Asn Gly Lys 
    50                  55                  60                  


Leu Val Ile Asn Gly Lys Pro Ile Thr Ile Phe Gln Glu Arg Asp Pro 
65                  70                  75                  80  


Thr Asn Ile Lys Trp Gly Glu Ala Gly Ala Glu Tyr Val Val Glu Ser 
                85                  90                  95      


Thr Gly Val Phe Thr Ile Met Glu Lys Ala Gly Ala His Leu Lys Gly 
            100                 105                 110         


Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala Pro Met 
        115                 120                 125             


Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu Lys Ile 
    130                 135                 140                 


Val Asn Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu Ser Lys 
145                 150                 155                 160 


Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr Thr Val 
                165                 170                 175     


His Ala Ile Thr Ala Thr Gln Lys Thr Val Gly Gly Pro Ser Gly Lys 
            180                 185                 190         


Leu Trp Arg Asp Gly Arg Gly Ala Ala Gln Asn Ile Ile Pro Ala Ser 
        195                 200                 205             


Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu Asn Gly 
    210                 215                 220                 


Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Pro Asn Val Ser Val 
225                 230                 235                 240 


Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp Asp Ile 
                245                 250                 255     


Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly Ile Leu 
            260                 265                 270         


Gly Tyr Thr Glu Asp Gln Val Val Ser Cys Asp Phe Asn Ser Asn Ser 
        275                 280                 285             


His Ser Ser Thr Phe Asp Ala Gly Ala Val Ile Ala Leu Asn Asp Asn 
    290                 295                 300                 


Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser Asn 
305                 310                 315                 320 


Arg Val Val Asp Leu Met Ala Tyr Met Ala Ser Lys Glu 
                325                 330             


<210>  6
<211>  366
<212>  PRT
<213>  Mus musculus

<400>  6

Met Leu Ser Leu Ser Pro His Phe Leu Ser Leu Gln Lys Val Asn Val 
1               5                   10                  15      


Val Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu Met Asp Gly Thr 
            20                  25                  30          


Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly Val Ser Leu 
        35                  40                  45              


Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro Leu Tyr Arg 
    50                  55                  60                  


His Ile Ala Asp Leu Ala Gly Asn Pro Glu Val Ile Leu Pro Val Pro 
65                  70                  75                  80  


Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala 
                85                  90                  95      


Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser Ser Phe Arg Glu 
            100                 105                 110         


Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile 
        115                 120                 125             


Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly 
    130                 135                 140                 


Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Ala Leu Glu Leu Leu Lys 
145                 150                 155                 160 


Thr Ala Ile Ala Lys Ala Gly Tyr Thr Asp Gln Val Val Ile Gly Met 
                165                 170                 175     


Asp Val Ala Ala Ser Glu Phe Tyr Arg Ser Gly Lys Tyr Asp Leu Asp 
            180                 185                 190         


Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Thr Pro Asp Gln Leu 
        195                 200                 205             


Ala Asp Leu Tyr Lys Ser Phe Val Gln Asn Tyr Pro Val Val Ser Ile 
    210                 215                 220                 


Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys Phe Thr 
225                 230                 235                 240 


Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val Thr Asn 
                245                 250                 255     


Pro Lys Arg Ile Ala Lys Ala Ala Ser Glu Lys Ser Cys Asn Cys Leu 
            260                 265                 270         


Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu Gln Ala 
        275                 280                 285             


Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met Val Ser His Arg 
    290                 295                 300                 


Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu 
305                 310                 315                 320 


Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu 
                325                 330                 335     


Ala Lys Tyr Asn Gln Ile Leu Arg Ile Glu Glu Glu Leu Gly Ser Lys 
            340                 345                 350         


Ala Lys Phe Ala Gly Arg Ser Phe Arg Asn Pro Leu Ala Lys 
        355                 360                 365     


<210>  7
<211>  434
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Arg Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Ile Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Asp Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Met 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Ala Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  8
<211>  334
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Ser Val Ala Asp Asp Glu 
1               5                   10                  15      


Ala Ala Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Thr Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Asp Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Arg Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  9
<211>  745
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Pro Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Val Ser Leu Ala Tyr Val Glu Ala Ala Gly Tyr Leu Thr Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Met Thr Leu 
    50                  55                  60                  


Lys Asn Thr Pro Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Cys Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Asn 
        115                 120                 125             


Leu Asp Val Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Leu Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Met Tyr Asp Leu Val Ala Gly Ser Gln Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Glu Thr Gly Lys Glu Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Ser Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asn 
    290                 295                 300                 


Val Val Pro Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Asn Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Glu Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Ser Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Asp Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Val 
        435                 440                 445             


Asp Ala Ala Val Lys Phe His Asn Leu Asn Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Lys Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Val Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Ser Glu Leu Arg Lys Gln Cys Val Thr 
            580                 585                 590         


Tyr Asp Ser Asp Gly Ser Thr Val Ala Thr Ser Trp Ser Ser Gln Glu 
        595                 600                 605             


Glu Leu Glu Thr Ala Thr Arg Phe Leu Tyr Tyr Glu Met Gly Tyr Lys 
    610                 615                 620                 


Ser Arg Thr Glu Gln Leu Thr Asp Ser Thr Glu Ile Ser Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Glu Asp 
                645                 650                 655     


Glu Lys Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser 
            660                 665                 670         


Ile Asn Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Cys Glu 
        675                 680                 685             


Val Asp Leu Asn Lys Asn Gly Gln Val Glu Leu His Glu Phe Leu Gln 
    690                 695                 700                 


Leu Met Ser Ala Val Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala 
705                 710                 715                 720 


Ile Leu Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile 
                725                 730                 735     


Pro Val Asp Arg Ser Cys Gly Gly Leu 
            740                 745 


<210>  10
<211>  373
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 
65                  70                  75                  80  


Pro Val Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Ser Asn 
            100                 105                 110         


Leu Arg His Ile Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Ile Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Trp Ile Glu Glu 
            260                 265                 270         


Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Gly 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 
            340                 345                 350         


Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  11
<211>  642
<212>  PRT
<213>  Mus musculus

<400>  11

Met Trp Arg Val Cys Ala Arg Arg Ala Arg Ser Ala Val Pro Arg Asp 
1               5                   10                  15      


Gly Phe Arg Ala Arg Trp Ala Ala Leu Lys Glu Gly Pro Gly Ala Pro 
            20                  25                  30          


Cys Gly Ser Pro Arg Ile Gly Pro Ala Ala Val Arg Cys Gly Ser Gly 
        35                  40                  45              


Ile Pro Arg Tyr Gly Val Arg Ser Leu Cys Gly Trp Ser Ser Gly Ser 
    50                  55                  60                  


Gly Thr Val Pro Arg Asn Arg Leu Leu Arg Gln Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Ser Arg Arg Ser Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro 
                85                  90                  95      


Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys 
            100                 105                 110         


Lys Glu Gly Glu Lys Ile Ser Glu Gly Asp Leu Ile Ala Glu Val Glu 
        115                 120                 125             


Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met 
    130                 135                 140                 


Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Val Gly Ser 
145                 150                 155                 160 


Ile Ile Cys Ile Thr Val Glu Lys Pro Gln Asp Ile Glu Ala Phe Lys 
                165                 170                 175     


Asn Tyr Thr Leu Asp Leu Ala Ala Ala Ala Ala Pro Gln Ala Ala Pro 
            180                 185                 190         


Ala Ala Ala Pro Ala Thr Ala Ala Ala Pro Ala Ala Pro Ser Ala Ser 
        195                 200                 205             


Ala Pro Gly Ser Ser Tyr Pro Thr His Met Gln Ile Val Leu Pro Ala 
    210                 215                 220                 


Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys Lys 
225                 230                 235                 240 


Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr 
                245                 250                 255     


Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala 
            260                 265                 270         


Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Ala Pro 
        275                 280                 285             


Leu Cys Ile Ile Val Glu Lys Gln Glu Asp Ile Ala Ala Phe Ala Asp 
    290                 295                 300                 


Tyr Arg Pro Thr Glu Val Thr Ser Leu Lys Pro Gln Ala Ala Pro Pro 
305                 310                 315                 320 


Ala Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Val Ala 
                325                 330                 335     


Pro Thr Pro Ser Ala Ala Pro Ala Gly Pro Lys Gly Arg Val Phe Val 
            340                 345                 350         


Ser Pro Leu Ala Lys Lys Leu Ala Ala Glu Lys Gly Ile Asp Leu Thr 
        355                 360                 365             


Gln Val Lys Gly Thr Gly Pro Glu Gly Arg Ile Ile Lys Lys Asp Ile 
    370                 375                 380                 


Asp Ser Phe Val Pro Ser Lys Ala Ala Pro Ala Ala Ala Ala Ala Met 
385                 390                 395                 400 


Ala Pro Pro Gly Pro Arg Val Ala Pro Ala Pro Ala Gly Val Phe Thr 
                405                 410                 415     


Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile Ala Gln Arg Leu Met 
            420                 425                 430         


Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu Ser Val Asp Val Asn 
        435                 440                 445             


Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu Asn Lys Met Leu Glu 
    450                 455                 460                 


Gly Lys Gly Lys Ile Ser Val Asn Asp Phe Ile Ile Lys Ala Ser Ala 
465                 470                 475                 480 


Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser Ser Trp Met Asp Thr 
                485                 490                 495     


Val Ile Arg Gln Asn His Val Val Asp Val Ser Val Ala Val Ser Thr 
            500                 505                 510         


Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn Ala His Ile Lys Gly 
        515                 520                 525             


Leu Glu Thr Ile Ala Ser Asp Val Val Ser Leu Ala Ser Lys Ala Arg 
    530                 535                 540                 


Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly Gly Thr Phe Thr Ile 
545                 550                 555                 560 


Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe Ser Ala Ile Ile Asn 
                565                 570                 575     


Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala Ser Glu Asp Lys Leu 
            580                 585                 590         


Ile Pro Ala Asp Asn Glu Lys Gly Phe Asp Val Ala Ser Val Met Ser 
        595                 600                 605             


Val Thr Leu Ser Cys Asp His Arg Val Val Asp Gly Ala Val Gly Ala 
    610                 615                 620                 


Gln Trp Leu Ala Glu Phe Lys Lys Tyr Leu Glu Lys Pro Ile Thr Met 
625                 630                 635                 640 


Leu Leu 
        


<210>  12
<211>  316
<212>  PRT
<213>  Mus musculus

<400>  12

Met Lys Ile Phe Asp Ala Ala Lys Ala Pro Ile Gln Trp Glu Glu Arg 
1               5                   10                  15      


Asn Val Thr Ala Ile Gln Gly Pro Gly Gly Lys Trp Met Ile Pro Pro 
            20                  25                  30          


Glu Ala Lys Glu Ser Met Asp Lys Asn Lys Met Gly Leu Lys Gly Pro 
        35                  40                  45              


Leu Lys Thr Pro Ile Ala Ala Gly His Pro Ser Met Asn Leu Leu Leu 
    50                  55                  60                  


Arg Lys Thr Phe Asp Leu Tyr Ala Asn Val Arg Pro Cys Val Ser Ile 
65                  70                  75                  80  


Glu Gly Tyr Lys Thr Pro Tyr Thr Asp Val Asn Ile Val Thr Ile Arg 
                85                  90                  95      


Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile Glu His Val Ile Val Asp 
            100                 105                 110         


Gly Val Val Gln Ser Ile Lys Leu Ile Thr Glu Glu Ala Ser Lys Arg 
        115                 120                 125             


Ile Ala Glu Phe Ala Phe Glu Tyr Ala Arg Asn Asn His Arg Ser Asn 
    130                 135                 140                 


Val Thr Ala Val His Lys Ala Asn Ile Met Arg Met Ser Asp Gly Leu 
145                 150                 155                 160 


Phe Leu Gln Lys Cys Arg Glu Val Ala Glu Asn Cys Lys Asp Ile Lys 
                165                 170                 175     


Phe Asn Glu Met Tyr Leu Asp Thr Val Cys Leu Asn Met Val Gln Asp 
            180                 185                 190         


Pro Ser Gln Phe Asp Val Leu Val Met Pro Asn Leu Tyr Gly Asp Ile 
        195                 200                 205             


Leu Ser Asp Leu Cys Ala Gly Leu Ile Gly Gly Leu Gly Val Thr Pro 
    210                 215                 220                 


Ser Gly Asn Ile Gly Ala Asn Gly Val Ala Ile Phe Glu Ser Val His 
225                 230                 235                 240 


Gly Thr Ala Pro Asp Ile Ala Gly Lys Asp Met Ala Asn Pro Thr Ala 
                245                 250                 255     


Leu Leu Leu Ser Ala Val Met Met Leu Arg His Met Gly Leu Phe Asp 
            260                 265                 270         


His Ala Ala Lys Ile Glu Ala Ala Cys Phe Ala Thr Ile Lys Asp Gly 
        275                 280                 285             


Lys Ser Leu Thr Lys Asp Leu Gly Gly Asn Ala Lys Cys Ser Asp Phe 
    290                 295                 300                 


Thr Glu Glu Ile Cys Arg Arg Val Lys Asp Leu Asp 
305                 310                 315     


<210>  13
<211>  334
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile 
1               5                   10                  15      


Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys 
            20                  25                  30          


Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly 
        35                  40                  45              


Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu 
    50                  55                  60                  


Leu Gln Asp Val Ile Ala Thr Asp Lys Glu Glu Ile Ala Phe Lys Asp 
65                  70                  75                  80  


Leu Asp Val Ala Val Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met 
                85                  90                  95      


Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln 
            100                 105                 110         


Gly Thr Ala Leu Glu Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val 
        115                 120                 125             


Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala 
    130                 135                 140                 


Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His 
145                 150                 155                 160 


Asn Arg Ala Lys Ser Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asp 
                165                 170                 175     


Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr 
            180                 185                 190         


Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly 
        195                 200                 205             


Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Ile 
    210                 215                 220                 


Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu 
225                 230                 235                 240 


Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Ala Asp His Ile Arg Asp 
                245                 250                 255     


Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile 
            260                 265                 270         


Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe 
        275                 280                 285             


Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro 
    290                 295                 300                 


Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu 
305                 310                 315                 320 


Thr Glu Glu Lys Glu Thr Ala Phe Glu Phe Leu Ser Ser Ala 
                325                 330                 


<210>  14
<211>  172
<212>  PRT
<213>  Mus musculus

<400>  14

Met Pro Gly Ile Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Glu 
1               5                   10                  15      


Glu Val Lys Val Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr 
            20                  25                  30          


Gly Ala Gln Cys Asp Lys Thr Asn Lys Glu Phe Met Leu Cys Arg Trp 
        35                  40                  45              


Glu Glu Lys Asp Pro Arg Arg Cys Leu Lys Glu Gly Lys Leu Val Asn 
    50                  55                  60                  


Gly Cys Ala Leu Asn Phe Phe Arg Gln Ile Lys Ser His Cys Ala Glu 
65                  70                  75                  80  


Pro Phe Thr Glu Tyr Trp Thr Cys Leu Asp Tyr Ser Asn Met Gln Leu 
                85                  90                  95      


Phe Arg His Cys Arg Gln Gln Gln Ala Lys Phe Asp Gln Cys Val Leu 
            100                 105                 110         


Asp Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Gln Leu Ser Lys Val 
        115                 120                 125             


Thr Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser 
    130                 135                 140                 


Arg Ala Arg Pro Glu Pro Asn Pro Val Ile Glu Gly Asp Leu Lys Pro 
145                 150                 155                 160 


Ala Lys His Gly Thr Arg Phe Phe Phe Trp Thr Val 
                165                 170         


<210>  15
<211>  727
<212>  PRT
<213>  Mus musculus

<400>  15

Met Leu Arg Ile Pro Ile Lys Arg Ala Leu Ile Gly Leu Ser Asn Ser 
1               5                   10                  15      


Pro Lys Gly Tyr Val Arg Thr Thr Gly Thr Ala Ala Ser Asn Leu Ile 
            20                  25                  30          


Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr 
        35                  40                  45              


Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys 
    50                  55                  60                  


Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val 
65                  70                  75                  80  


Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val 
                85                  90                  95      


Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala 
            100                 105                 110         


Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys 
        115                 120                 125             


Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met 
    130                 135                 140                 


Met Phe Gly Ser Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val 
145                 150                 155                 160 


Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys 
                165                 170                 175     


Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val 
            180                 185                 190         


Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr 
        195                 200                 205             


Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Val Ile Asp 
    210                 215                 220                 


Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala 
225                 230                 235                 240 


Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala 
                245                 250                 255     


Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg 
            260                 265                 270         


Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp 
        275                 280                 285             


Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu 
    290                 295                 300                 


Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu 
305                 310                 315                 320 


Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Asn Phe Glu Gly Asn 
                325                 330                 335     


Ala Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val 
            340                 345                 350         


Ala Leu Lys Asp Leu Leu Asn Lys Val Asp Ser Asp Asn Leu Cys Thr 
        355                 360                 365             


Glu Glu Ile Phe Pro Thr Glu Gly Ala Gly Thr Asp Leu Arg Ser Asn 
    370                 375                 380                 


Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val 
385                 390                 395                 400 


Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala 
                405                 410                 415     


Arg Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile 
            420                 425                 430         


Gly Ser Pro Val Asp Leu Thr Tyr Arg Tyr Asp His Leu Gly Asp Ser 
        435                 440                 445             


Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Arg His Ser Phe Cys Glu 
    450                 455                 460                 


Val Leu Lys Asp Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala 
465                 470                 475                 480 


Leu Gln Arg Asp Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Asn Met 
                485                 490                 495     


Val Gln Lys Ile Arg Val Thr Thr Gly Val Ala Ala Glu Trp Lys Val 
            500                 505                 510         


Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu 
        515                 520                 525             


Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Met 
    530                 535                 540                 


Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu 
545                 550                 555                 560 


Pro Lys Asp Cys Phe Ile Val Tyr Gln Gly His His Gly Asp Val Gly 
                565                 570                 575     


Ala Pro Met Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys 
            580                 585                 590         


Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val 
        595                 600                 605             


Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg 
    610                 615                 620                 


Ala Leu Ser Glu Ile Ala Gly Ile Thr Leu Pro Tyr Asp Thr Leu Asp 
625                 630                 635                 640 


Gln Val Arg Asn Arg Leu Glu Glu Val Ser Pro Asn Leu Val Arg Tyr 
                645                 650                 655     


Asp Asp Ile Glu Glu Thr Asn Tyr Phe Gln Gln Ala Ser Glu Leu Ala 
            660                 665                 670         


Lys Leu Val Asn Gln Glu Val Leu Ala Asp Pro Leu Val Pro Pro Gln 
        675                 680                 685             


Leu Thr Ile Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser 
    690                 695                 700                 


Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala 
705                 710                 715                 720 


Val Glu Glu Pro Ser Ile Cys 
                725         


<210>  16
<211>  212
<212>  PRT
<213>  Mus musculus

<400>  16

Met Tyr Arg Leu Ser Ser Ser Met Leu Pro Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Met Arg Thr Gly His Leu Asn Gly Gln Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Lys Lys Glu Gln Glu Ser Glu Val 
        35                  40                  45              


Asp Met Lys Ser Ala Thr Asp Asn Ala Ala Arg Ile Leu Met Trp Thr 
    50                  55                  60                  


Glu Leu Ile Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu 
65                  70                  75                  80  


Pro Ala Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg 
                85                  90                  95      


Phe Arg Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg 
            100                 105                 110         


Cys Ile Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile 
        115                 120                 125             


Thr Ile Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg 
    130                 135                 140                 


Tyr Asp Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu 
145                 150                 155                 160 


Ala Cys Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser 
                165                 170                 175     


Thr Glu Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn 
            180                 185                 190         


Asn Gly Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp 
        195                 200                 205             


Tyr Leu Tyr Arg 
    210         


<210>  17
<211>  480
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ala Ala Ser Ala Val Cys Arg Ala Ala Cys Ser Gly Thr Gln Val 
1               5                   10                  15      


Leu Leu Arg Thr Arg Arg Ser Pro Ala Leu Leu Arg Leu Pro Ala Leu 
            20                  25                  30          


Arg Gly Thr Ala Thr Phe Ala Gln Ala Leu Gln Ser Val Pro Glu Thr 
        35                  40                  45              


Gln Val Ser Ile Leu Asp Asn Gly Leu Arg Val Ala Ser Glu Gln Ser 
    50                  55                  60                  


Ser His Ala Thr Cys Thr Val Gly Val Trp Ile Asp Ala Gly Ser Arg 
65                  70                  75                  80  


Tyr Glu Thr Glu Lys Asn Asn Gly Ala Gly Tyr Phe Leu Glu His Leu 
                85                  90                  95      


Ala Phe Lys Gly Thr Lys Asn Arg Pro Gly Asn Ala Leu Glu Lys Glu 
            100                 105                 110         


Val Glu Ser Ile Gly Ala His Leu Asn Ala Tyr Ser Thr Arg Glu His 
        115                 120                 125             


Thr Ala Tyr Leu Ile Lys Ala Leu Ser Lys Asp Leu Pro Lys Val Val 
    130                 135                 140                 


Glu Leu Leu Ala Asp Ile Val Gln Asn Ser Ser Leu Glu Asp Ser Gln 
145                 150                 155                 160 


Ile Glu Lys Glu Arg Asp Val Ile Leu Arg Glu Met Gln Glu Asn Asp 
                165                 170                 175     


Ala Ser Met Gln Asn Val Val Phe Asp Tyr Leu His Ala Thr Ala Phe 
            180                 185                 190         


Gln Gly Thr Pro Leu Ala Gln Ala Val Glu Gly Pro Ser Glu Asn Val 
        195                 200                 205             


Arg Arg Leu Ser Arg Thr Asp Leu Thr Asp Tyr Leu Asn Arg Asn Tyr 
    210                 215                 220                 


Lys Ala Pro Arg Met Val Leu Ala Ala Ala Gly Gly Val Glu His Gln 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Ala Gln Lys His Leu Ser Ser Val Ser Arg Val 
                245                 250                 255     


Tyr Glu Glu Asp Ala Val Pro Gly Leu Thr Pro Cys Arg Phe Thr Gly 
            260                 265                 270         


Ser Glu Ile Arg His Arg Asp Asp Ala Leu Pro Leu Ala His Val Ala 
        275                 280                 285             


Ile Ala Val Glu Gly Pro Gly Trp Ala Asn Pro Asp Asn Val Thr Leu 
    290                 295                 300                 


Gln Val Ala Asn Ala Ile Ile Gly His Tyr Asp Cys Thr Cys Gly Gly 
305                 310                 315                 320 


Gly Val His Leu Ser Ser Pro Leu Ala Ser Val Ala Val Ala Asn Lys 
                325                 330                 335     


Leu Cys Gln Ser Phe Gln Thr Phe Asn Ile Ser Tyr Ser Asp Thr Gly 
            340                 345                 350         


Leu Leu Gly Ala His Phe Val Cys Asp Ala Met Ser Ile Asp Asp Met 
        355                 360                 365             


Val Phe Phe Leu Gln Gly Gln Trp Met Arg Leu Cys Thr Ser Ala Thr 
    370                 375                 380                 


Glu Ser Glu Val Thr Arg Gly Lys Asn Ile Leu Arg Asn Ala Leu Val 
385                 390                 395                 400 


Ser His Leu Asp Gly Thr Thr Pro Val Cys Glu Asp Ile Gly Arg Ser 
                405                 410                 415     


Leu Leu Thr Tyr Gly Arg Arg Ile Pro Leu Ala Glu Trp Glu Ser Arg 
            420                 425                 430         


Ile Gln Glu Val Asp Ala Gln Met Leu Arg Asp Ile Cys Ser Lys Tyr 
        435                 440                 445             


Phe Tyr Asp Gln Cys Pro Ala Val Ala Gly Tyr Gly Pro Ile Glu Gln 
    450                 455                 460                 


Leu Pro Asp Tyr Asn Arg Ile Arg Ser Gly Met Phe Trp Leu Arg Phe 
465                 470                 475                 480 


<210>  18
<211>  161
<212>  PRT
<213>  Mus musculus

<400>  18

Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ser Phe 
1               5                   10                  15      


Val Glu Val Met Pro Gln Asn Gln Lys Ala Ile Gly Asn Ala Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Phe His Ala Arg Leu Ala Ser Leu Ser Glu Lys 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Arg Ala Asn Val Ala Lys Pro 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Tyr Asn Ala Leu Lys Ile Pro 
65                  70                  75                  80  


Val Pro Glu Asp Lys Tyr Thr Ala Leu Val Asp Gln Glu Glu Lys Glu 
                85                  90                  95      


Asp Val Lys Ser Cys Ala Glu Phe Val Ser Gly Ser Gln Leu Arg Ile 
            100                 105                 110         


Gln Glu Tyr Glu Lys Gln Leu Glu Lys Met Arg Asn Ile Ile Pro Phe 
        115                 120                 125             


Asp Gln Met Thr Ile Asp Asp Leu Asn Glu Ile Phe Pro Glu Thr Lys 
    130                 135                 140                 


Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn 
145                 150                 155                 160 


Leu 
    


<210>  19
<211>  381
<212>  PRT
<213>  Mus musculus

<400>  19

Met Pro Phe Ser Asn Ser His Asn Thr Gln Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      


Glu Asp Glu Phe Pro Asp Leu Ser Ser His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Cys Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Leu Asp Asp Ala Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Tyr Ile Met Thr Val Gly Ala Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Asp Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Glu Arg 
                85                  90                  95      


His Gly Gly Tyr Gln Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         


Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 


Ala Leu Ser Ser Leu Asp Gly Asp Leu Ser Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 


Phe Leu Val Trp Ile Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     


Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asn Tyr Glu Phe Met 
            260                 265                 270         


Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro His Leu Gly Lys 
    290                 295                 300                 


His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             


Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     


<210>  20
<211>  646
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Ser Trp Leu Asp Lys Asn Gln Thr Ala Glu Glu Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  21
<211>  679
<212>  PRT
<213>  Mus musculus

<400>  21

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Ala 
1               5                   10                  15      


Ala Ser Arg Ser Pro Ala Ala Ala Arg Pro Gln Asp Gly Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Ala Leu Leu Ala Gly 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  22
<211>  679
<212>  PRT
<213>  Mus musculus

<400>  22

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Ala 
1               5                   10                  15      


Ala Ser Arg Ser Pro Ala Ala Ala Arg Pro Gln Asp Gly Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Ile Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Asp Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Ala Leu Leu Ala Gly 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  23
<211>  505
<212>  PRT
<213>  Mus musculus

<400>  23

Met Arg Phe Ser Cys Leu Ala Leu Leu Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Glu Asn Phe Glu Ser Arg Val Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Val Val Gly Phe Phe 
145                 150                 155                 160 


Arg Asp Leu Phe Ser Asp Gly His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Ile Glu Ser Leu 
            180                 185                 190         


Val Lys Glu Tyr Asp Asp Asn Gly Glu Gly Ile Thr Ile Phe Arg Pro 
        195                 200                 205             


Leu His Leu Ala Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Lys Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Asp Ser Ile 
225                 230                 235                 240 


Phe Gly Leu Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Thr Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Thr 
305                 310                 315                 320 


Gly Glu Val Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Gln Phe 
            340                 345                 350         


Leu Gln Glu Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Glu Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Asp Ile Val Asn Glu Glu Asp Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Lys 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Thr Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Asn Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Ile Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  24
<211>  617
<212>  PRT
<213>  Mus musculus

<400>  24

Met Asp Phe Ser Lys Leu Pro Lys Ile Arg Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Thr Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Thr Ala Cys 
            20                  25                  30          


Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser 
        35                  40                  45              


Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile 
    50                  55                  60                  


Gln Val Tyr Glu Glu Thr Ser Gly Val Ser Val Gly Asp Pro Val Leu 
65                  70                  75                  80  


Arg Thr Gly Lys Pro Arg Ser Val Glu Leu Gly Pro Gly Ile Met Gly 
                85                  90                  95      


Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln 
            100                 105                 110         


Thr Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser 
        115                 120                 125             


Arg Asp Ile Lys Trp Glu Phe Ile Pro Ser Lys Asn Leu Arg Val Gly 
    130                 135                 140                 


Ser His Ile Thr Gly Gly Asp Ile Tyr Gly Ile Val Asn Glu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Ser Val 
                165                 170                 175     


Thr Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Ala Ser Asn Val Val Leu 
            180                 185                 190         


Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Ser Met Val Gln Val 
        195                 200                 205             


Trp Pro Val Arg Gln Val Arg Pro Val Thr Glu Lys Leu Pro Ala Asn 
    210                 215                 220                 


His Pro Leu Leu Thr Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys 
225                 230                 235                 240 


Val Gln Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys 
                245                 250                 255     


Thr Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile 
            260                 265                 270         


Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu 
        275                 280                 285             


Arg Asp Phe Pro Glu Leu Thr Met Glu Val Asp Gly Lys Ala Glu Ser 
    290                 295                 300                 


Ile Met Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val 
305                 310                 315                 320 


Ala Ala Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr 
                325                 330                 335     


Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Thr Ser 
            340                 345                 350         


Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met 
        355                 360                 365             


Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser 
    370                 375                 380                 


Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg 
385                 390                 395                 400 


Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp 
                405                 410                 415     


Phe Ser Asp Pro Val Thr Ser Ala Thr Leu Gly Ile Val Gln Val Phe 
            420                 425                 430         


Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val 
        435                 440                 445             


Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr 
    450                 455                 460                 


Tyr Asp Lys His Phe Thr Glu Phe Val Pro Leu Arg Thr Lys Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Gln Glu Glu Gly Asp Leu Ala Glu Ile Val Gln Leu Val 
                485                 490                 495     


Gly Lys Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala 
            500                 505                 510         


Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Thr Pro Tyr 
        515                 520                 525             


Asp Arg Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Ser Asn Met 
    530                 535                 540                 


Ile Ser Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Thr Thr Ala Gln 
545                 550                 555                 560 


Ser Asp Asn Lys Ile Thr Trp Ser Ile Ile Arg Glu His Met Gly Glu 
                565                 570                 575     


Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Val Lys Asp 
            580                 585                 590         


Gly Glu Ala Lys Ile Lys Ala Asp Tyr Ala Gln Leu Leu Glu Asp Met 
        595                 600                 605             


Gln Asn Ala Phe Arg Ser Leu Glu Asp 
    610                 615         


<210>  25
<211>  418
<212>  PRT
<213>  Mus musculus

<400>  25

Met Glu Glu Ile Gly Ile Leu Val Glu Lys Ile Gln Asp Glu Ile Pro 
1               5                   10                  15      


Ala Leu Ser Val Ser Arg Pro Gln Thr Gly Leu Ser Phe Leu Gly Pro 
            20                  25                  30          


Glu Pro Glu Asp Leu Glu Asp Leu Tyr Ser Arg Tyr Lys Lys Leu Gln 
        35                  40                  45              


Gln Glu Leu Glu Phe Leu Glu Val Gln Glu Glu Tyr Ile Lys Asp Glu 
    50                  55                  60                  


Gln Lys Asn Leu Lys Lys Glu Phe Leu His Ala Gln Glu Glu Val Lys 
65                  70                  75                  80  


Arg Ile Gln Ser Ile Pro Leu Val Ile Gly Gln Phe Leu Glu Ala Val 
                85                  90                  95      


Asp Gln Asn Thr Ala Ile Val Gly Ser Thr Thr Gly Ser Asn Tyr Tyr 
            100                 105                 110         


Val Arg Ile Leu Ser Thr Ile Asp Arg Glu Leu Leu Lys Pro Asn Ala 
        115                 120                 125             


Ser Val Ala Leu His Lys His Ser Asn Ala Leu Val Asp Val Leu Pro 
    130                 135                 140                 


Pro Glu Ala Asp Ser Ser Ile Met Met Leu Thr Ser Asp Gln Lys Pro 
145                 150                 155                 160 


Asp Val Met His Ala Asp Ile Gly Gly Met Asp Ile Gln Lys Gln Glu 
                165                 170                 175     


Val Arg Glu Ala Val Glu Leu Pro Leu Thr His Phe Glu Leu Tyr Lys 
            180                 185                 190         


Gln Ile Gly Ile Asp Pro Pro Arg Gly Val Leu Met Tyr Gly Pro Pro 
        195                 200                 205             


Gly Cys Gly Lys Thr Met Leu Ala Lys Ala Val Ala His His Thr Thr 
    210                 215                 220                 


Ala Ala Phe Ile Arg Val Val Gly Ser Glu Phe Val Gln Lys Tyr Leu 
225                 230                 235                 240 


Gly Glu Gly Pro Arg Met Val Arg Asp Val Phe Arg Leu Ala Lys Glu 
                245                 250                 255     


Asn Ala Pro Ala Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Ala Thr 
            260                 265                 270         


Lys Arg Phe Asp Ala Gln Thr Gly Ala Asp Arg Glu Val Gln Arg Ile 
        275                 280                 285             


Leu Leu Glu Leu Leu Asn Gln Met Asp Gly Phe Asp Gln Asn Val Asn 
    290                 295                 300                 


Val Lys Val Ile Met Ala Thr Asn Arg Ala Asp Thr Leu Asp Pro Ala 
305                 310                 315                 320 


Leu Leu Arg Pro Gly Arg Leu Asp Arg Lys Ile Glu Phe Pro Leu Pro 
                325                 330                 335     


Asp Arg Arg Gln Lys Arg Leu Ile Phe Ser Thr Ile Thr Ser Lys Met 
            340                 345                 350         


Asn Leu Ser Glu Glu Val Asp Leu Glu Asp Tyr Val Ala Arg Pro Asp 
        355                 360                 365             


Lys Ile Ser Gly Ala Asp Ile Asn Ser Ile Cys Gln Glu Ser Gly Met 
    370                 375                 380                 


Leu Ala Val Arg Glu Asn Arg Tyr Ile Val Leu Ala Lys Asp Phe Glu 
385                 390                 395                 400 


Lys Ala Tyr Lys Thr Val Ile Lys Lys Asp Glu Gln Glu His Glu Phe 
                405                 410                 415     


Tyr Lys 
        


<210>  26
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ala Lys Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser 
1               5                   10                  15      


Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly 
            20                  25                  30          


Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr 
        35                  40                  45              


Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys 
    50                  55                  60                  


Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly 
65                  70                  75                  80  


Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln 
                85                  90                  95      


Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln 
            100                 105                 110         


Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg 
        115                 120                 125             


Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro 
    130                 135                 140                 


Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala 
145                 150                 155                 160 


Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys 
                165                 170                 175     


Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile 
            180                 185                 190         


Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile 
        195                 200                 205             


Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr 
    210                 215                 220                 


Glu Val Arg Asp Tyr Leu Ala Ala Ile Ala 
225                 230                 


<210>  27
<211>  233
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Leu Cys Leu Gln Val Pro Ser Ala Lys Met Gln Leu Lys Pro Met 
1               5                   10                  15      


Glu Ile Asn Pro Glu Met Leu Asn Lys Val Leu Ala Lys Leu Gly Val 
            20                  25                  30          


Ala Gly Gln Trp Arg Phe Ala Asp Val Leu Gly Leu Glu Glu Glu Thr 
        35                  40                  45              


Leu Gly Ser Val Pro Ser Pro Ala Cys Ala Leu Leu Leu Leu Phe Pro 
    50                  55                  60                  


Leu Thr Ala Gln His Glu Asn Phe Arg Lys Lys Gln Ile Glu Glu Leu 
65                  70                  75                  80  


Lys Gly Gln Glu Val Ser Pro Lys Val Tyr Phe Met Lys Gln Thr Ile 
                85                  90                  95      


Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile His Ala Val Ala Asn Asn 
            100                 105                 110         


Gln Asp Lys Leu Glu Phe Glu Asp Gly Ser Val Leu Lys Gln Phe Leu 
        115                 120                 125             


Ser Glu Thr Glu Lys Leu Ser Pro Glu Asp Arg Ala Lys Cys Phe Glu 
    130                 135                 140                 


Lys Asn Glu Ala Ile Gln Ala Ala His Asp Ser Val Ala Gln Glu Gly 
145                 150                 155                 160 


Gln Cys Arg Val Asp Asp Lys Val Asn Phe His Phe Ile Leu Phe Asn 
                165                 170                 175     


Asn Val Asp Gly His Leu Tyr Glu Leu Asp Gly Arg Met Pro Phe Pro 
            180                 185                 190         


Val Asn His Gly Ala Ser Ser Glu Asp Ser Leu Leu Gln Asp Ala Ala 
        195                 200                 205             


Lys Val Cys Arg Glu Phe Thr Glu Arg Glu Gln Gly Glu Val Arg Phe 
    210                 215                 220                 


Ser Ala Val Ala Leu Cys Lys Ala Ala 
225                 230             


<210>  28
<211>  822
<212>  PRT
<213>  Mus musculus

<400>  28

Pro Leu Pro Ser Gly Arg His Ser Arg Arg Pro Gly Glu Ala Arg Ala 
1               5                   10                  15      


Met Ala Ser Gly Ala Asp Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile 
            20                  25                  30          


Leu Lys Gln Lys Asn Arg Pro Asn Arg Leu Ile Val Asp Glu Ala Ile 
        35                  40                  45              


Asn Glu Asp Asn Ser Val Val Ser Leu Ser Gln Pro Lys Met Asp Glu 
    50                  55                  60                  


Leu Gln Leu Phe Arg Gly Asp Thr Val Leu Leu Lys Gly Lys Lys Arg 
65                  70                  75                  80  


Arg Glu Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser Asp Glu 
                85                  90                  95      


Lys Ile Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val Arg Leu 
            100                 105                 110         


Gly Asp Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys 
        115                 120                 125             


Arg Ile His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile Thr Gly 
    130                 135                 140                 


Asn Leu Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg 
145                 150                 155                 160 


Pro Ile Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met Arg Ala 
                165                 170                 175     


Val Glu Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val 
            180                 185                 190         


Ala Pro Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys Arg Glu 
        195                 200                 205             


Asp Glu Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly 
    210                 215                 220                 


Cys Arg Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu Pro Leu 
225                 230                 235                 240 


Arg His Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro Arg Gly 
                245                 250                 255     


Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg 
            260                 265                 270         


Ala Val Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro 
        275                 280                 285             


Glu Ile Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys 
    290                 295                 300                 


Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp 
305                 310                 315                 320 


Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu Val 
                325                 330                 335     


Glu Arg Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly Leu Lys 
            340                 345                 350         


Gln Arg Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro Asn Ser 
        355                 360                 365             


Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu Val Asp 
    370                 375                 380                 


Ile Gly Ile Pro Asp Ala Thr Gly Arg Leu Glu Ile Leu Gln Ile His 
385                 390                 395                 400 


Thr Lys Asn Met Lys Leu Ala Asp Asp Val Asp Leu Glu Gln Val Ala 
                405                 410                 415     


Asn Glu Thr His Gly His Val Gly Ala Asp Leu Ala Ala Leu Cys Ser 
            420                 425                 430         


Glu Ala Ala Leu Gln Ala Ile Arg Lys Lys Met Asp Leu Ile Asp Leu 
        435                 440                 445             


Glu Asp Glu Thr Ile Asp Ala Glu Val Met Asn Ser Leu Ala Val Thr 
    450                 455                 460                 


Met Asp Asp Phe Arg Trp Ala Leu Ser Gln Ser Asn Pro Ser Ala Leu 
465                 470                 475                 480 


Arg Glu Thr Val Val Glu Val Pro Gln Val Thr Trp Glu Asp Ile Gly 
                485                 490                 495     


Gly Leu Glu Asp Val Lys Arg Glu Leu Gln Glu Leu Val Gln Tyr Pro 
            500                 505                 510         


Val Glu His Pro Asp Lys Phe Leu Lys Phe Gly Met Thr Pro Ser Lys 
        515                 520                 525             


Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala 
    530                 535                 540                 


Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn Phe Ile Ser Ile Lys Gly 
545                 550                 555                 560 


Pro Glu Leu Leu Thr Met Trp Phe Gly Glu Ser Glu Ala Asn Val Arg 
                565                 570                 575     


Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala Pro Cys Val Leu Phe Phe 
            580                 585                 590         


Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg Gly Gly Asn Ile Gly Asp 
        595                 600                 605             


Gly Gly Gly Ala Ala Asp Arg Val Ile Asn Gln Ile Leu Thr Glu Met 
    610                 615                 620                 


Asp Gly Met Ser Thr Lys Lys Asn Val Phe Ile Ile Gly Ala Thr Asn 
625                 630                 635                 640 


Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp 
                645                 650                 655     


Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu Lys Ser Arg Val Ala Ile 
            660                 665                 670         


Leu Lys Ala Asn Leu Arg Lys Ser Pro Val Ala Lys Asp Val Asp Leu 
        675                 680                 685             


Glu Phe Leu Ala Lys Met Thr Asn Gly Phe Ser Gly Ala Asp Leu Thr 
    690                 695                 700                 


Glu Ile Cys Gln Arg Ala Cys Lys Leu Ala Ile Arg Glu Ser Ile Glu 
705                 710                 715                 720 


Ser Glu Ile Arg Arg Glu Arg Glu Arg Gln Thr Asn Pro Ser Ala Met 
                725                 730                 735     


Glu Val Glu Glu Asp Asp Pro Val Pro Glu Ile Arg Arg Asp His Phe 
            740                 745                 750         


Glu Glu Ala Met Arg Phe Ala Arg Arg Ser Val Ser Asp Asn Asp Ile 
        755                 760                 765             


Arg Lys Tyr Glu Met Phe Ala Gln Thr Leu Gln Gln Ser Arg Gly Phe 
    770                 775                 780                 


Gly Ser Phe Arg Phe Pro Ser Gly Asn Gln Gly Gly Ala Gly Pro Ser 
785                 790                 795                 800 


Gln Gly Ser Gly Gly Gly Thr Gly Gly Ser Val Tyr Thr Glu Asp Asn 
                805                 810                 815     


Asp Asp Asp Leu Tyr Gly 
            820         


<210>  29
<211>  334
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ala Ala Ser Leu Gly Phe Arg Gly Ala Ala Ser Gly Leu Trp Tyr 
1               5                   10                  15      


Trp Ser Gly Arg Arg Arg Pro Val Gly Ser Leu Ala Ala Val Cys Ser 
            20                  25                  30          


Arg Ser Met Ala Ser Lys Thr Pro Val Gly Phe Ile Gly Leu Gly Asn 
        35                  40                  45              


Met Gly Asn Pro Met Ala Lys Asn Leu Met Lys His Gly Tyr Pro Leu 
    50                  55                  60                  


Ile Leu Tyr Asp Val Phe Pro Asp Val Cys Lys Glu Phe Lys Glu Ala 
65                  70                  75                  80  


Gly Glu Gln Val Ala Ser Ser Pro Ala Glu Val Ala Glu Lys Ala Asp 
                85                  90                  95      


Arg Ile Ile Thr Met Leu Pro Ser Ser Met Asn Ala Val Glu Val Tyr 
            100                 105                 110         


Ser Gly Ala Asn Gly Ile Leu Lys Lys Val Lys Lys Gly Ser Leu Leu 
        115                 120                 125             


Ile Asp Ser Ser Thr Met Ile Leu Gln Phe Gln Lys Asn Gly Lys Arg 
    130                 135                 140                 


Ser Glu Lys Met Gly Ala Val Phe Met Asp Ala Pro Val Ser Gly Gly 
145                 150                 155                 160 


Val Gly Ala Ala Arg Ser Gly Asn Leu Thr Phe Met Val Gly Gly Val 
                165                 170                 175     


Glu Asp Glu Phe Ala Ala Ala Gln Glu Leu Leu Glu Cys Met Gly Ser 
            180                 185                 190         


Asn Val Val Tyr Cys Gly Ala Val Gly Thr Gly Gln Ser Ala Gln Ile 
        195                 200                 205             


Cys Asn Asn Met Leu Leu Ala Ile Ser Met Ile Gly Thr Ala Glu Ala 
    210                 215                 220                 


Met Asn Leu Gly Ile Arg Ser Gly Leu Asp Pro Lys Leu Leu Ala Lys 
225                 230                 235                 240 


Ile Leu Asn Met Ser Ser Gly Arg Cys Trp Ser Ser Asp Thr Tyr Asn 
                245                 250                 255     


Pro Val Pro Gly Phe Met His Gly Val Pro Ser Ser Asn Asn Tyr Gln 
            260                 265                 270         


Gly Gly Phe Gly Thr Thr Leu Met Ala Lys Asp Leu Gly Leu Ala Gln 
        275                 280                 285             


Asp Ser Ala Thr Ser Thr Lys Thr Pro Ile Leu Leu Gly Ser Leu Ala 
    290                 295                 300                 


His Gln Ile Tyr Arg Met Met Cys Ser Lys Gly Tyr Ser Lys Lys Asp 
305                 310                 315                 320 


Phe Ser Ser Val Phe Gln Tyr Leu Arg Glu Glu Glu Pro Phe 
                325                 330                 


<210>  30
<211>  291
<212>  PRT
<213>  Mus musculus

<400>  30

Met Ala Thr Ala Thr Val Arg Pro Ala Ala Gln Arg Leu Arg Leu Leu 
1               5                   10                  15      


Leu Ser Pro Leu Lys Ser Arg Ile Cys Val Pro Gln Ala Glu Pro Val 
            20                  25                  30          


Ala Thr Phe Gly Thr Ala Val Thr Ser Ala Lys Val Ala Val Asn Gly 
        35                  40                  45              


Val His Leu His Tyr Gln Arg Val Gly Glu Gly Glu His Ala Ile Leu 
    50                  55                  60                  


Leu Leu Pro Gly Met Leu Gly Ser Gly Lys Thr Asp Phe Ala Pro Gln 
65                  70                  75                  80  


Leu Gln Ser Leu Asn Lys Lys Arg Phe Thr Leu Val Ala Trp Asp Pro 
                85                  90                  95      


Arg Gly Tyr Gly Tyr Ser Arg Pro Pro Asp Arg Asp Phe Pro Arg Asp 
            100                 105                 110         


Phe Phe Glu Arg Asp Ala Lys Asp Ala Val Asp Leu Met Lys Ala Leu 
        115                 120                 125             


Gln Phe Lys Gln Val Ser Leu Leu Gly Trp Ser Asp Gly Gly Ile Thr 
    130                 135                 140                 


Ala Leu Ile Ala Ala Ala Lys Tyr Pro Ser Tyr Ile Arg Lys Met Val 
145                 150                 155                 160 


Ile Trp Gly Ala Asn Ala Tyr Val Thr Glu Glu Asp Ser Arg Ile Tyr 
                165                 170                 175     


Gln Gly Ile Arg Asp Val Ser Lys Trp Ser Glu Lys Ala Arg Lys Pro 
            180                 185                 190         


Leu Glu Ala Leu Tyr Gly Tyr Asp Tyr Leu Ala Lys Thr Cys Glu Asp 
        195                 200                 205             


Trp Val Asp Gly Ile Ser Gln Phe Lys Gln Leu Pro Glu Gly Asn Ile 
    210                 215                 220                 


Cys Arg His Leu Leu Pro Leu Val Gln Cys Pro Thr Leu Ile Val His 
225                 230                 235                 240 


Gly Glu Lys Asp Pro Leu Val Pro Arg Phe His Ala Asp Phe Leu Leu 
                245                 250                 255     


Gln His Val Lys Gly Ser Arg Leu His Leu Met Pro Glu Gly Lys His 
            260                 265                 270         


Asn Leu His Leu Arg Phe Ala Asp Glu Phe Asn Arg Leu Val Glu Asp 
        275                 280                 285             


Phe Leu Gln 
    290     


<210>  31
<211>  259
<212>  PRT
<213>  Mus musculus

<400>  31

Met Ala Ala Arg Arg Ala Leu Lys Ala Val Leu Val Asp Leu Asn Gly 
1               5                   10                  15      


Thr Leu His Ile Glu Asp Ala Ala Val Pro Gly Ala Gln Glu Ala Leu 
            20                  25                  30          


Lys Arg Leu Arg Ala Thr Ser Val Met Val Arg Phe Val Thr Asn Thr 
        35                  40                  45              


Thr Lys Glu Thr Lys Lys Asp Leu Leu Glu Arg Leu Lys Lys Leu Glu 
    50                  55                  60                  


Phe Glu Ile Ser Glu Asp Glu Ile Phe Thr Ser Leu Thr Ala Ala Arg 
65                  70                  75                  80  


Asn Leu Ile Glu Gln Lys Gln Val Arg Pro Met Leu Leu Val Asp Asp 
                85                  90                  95      


Arg Ala Leu Pro Glu Phe Thr Gly Val Gln Thr Gln Asp Pro Asn Ala 
            100                 105                 110         


Val Val Ile Gly Leu Ala Pro Glu His Phe His Tyr Gln Leu Leu Asn 
        115                 120                 125             


Gln Ala Phe Arg Leu Leu Leu Asp Gly Ala Pro Leu Ile Ala Ile His 
    130                 135                 140                 


Lys Ala Arg Tyr Tyr Lys Arg Lys Asp Gly Leu Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Pro Phe Val Thr Ala Leu Glu Tyr Ala Thr Asp Thr Lys Ala Met Val 
                165                 170                 175     


Val Gly Lys Pro Glu Lys Thr Phe Phe Leu Glu Ala Leu Arg Asp Ala 
            180                 185                 190         


Asp Cys Ala Pro Glu Glu Ala Val Met Ile Gly Asp Asp Cys Arg Asp 
        195                 200                 205             


Asp Val Asp Gly Ala Gln Asn Ile Gly Met Leu Gly Ile Leu Val Lys 
    210                 215                 220                 


Thr Gly Lys Tyr Lys Ala Ala Asp Glu Glu Lys Ile Asn Pro Pro Pro 
225                 230                 235                 240 


Tyr Leu Thr Cys Glu Ser Phe Pro His Ala Val Asp His Ile Leu Gln 
                245                 250                 255     


His Leu Leu 
            


<210>  32
<211>  349
<212>  PRT
<213>  Mus musculus

<400>  32

Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Ser Arg His Gln Gly 
1               5                   10                  15      


Val Met Val Gly Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala 
            20                  25                  30          


Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly 
        35                  40                  45              


Ile Val Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe 
    50                  55                  60                  


Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Val Leu Leu Thr 
65                  70                  75                  80  


Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile 
                85                  90                  95      


Met Phe Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala 
            100                 105                 110         


Val Leu Ser Leu Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Met Asp 
        115                 120                 125             


Ser Gly Asp Gly Val Thr His Thr Val Pro Ile Tyr Glu Gly Tyr Ala 
    130                 135                 140                 


Leu Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr 
145                 150                 155                 160 


Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr 
                165                 170                 175     


Thr Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr 
            180                 185                 190         


Val Ala Leu Asp Phe Glu Gln Glu Met Ala Thr Ala Ala Ser Ser Ser 
        195                 200                 205             


Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile 
    210                 215                 220                 


Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe 
225                 230                 235                 240 


Leu Gly Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe Asn Ser Ile 
                245                 250                 255     


Met Lys Cys Asp Val Asp Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val 
            260                 265                 270         


Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln 
        275                 280                 285             


Lys Glu Ile Thr Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile 
    290                 295                 300                 


Ala Pro Pro Glu Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu 
305                 310                 315                 320 


Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr 
                325                 330                 335     


Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe 
            340                 345                 


<210>  33
<211>  368
<212>  PRT
<213>  Mus musculus

<400>  33

Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly Phe Ala Gly 
1               5                   10                  15      


Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg 
            20                  25                  30          


His Gln Gly Val Met Val Gly Met Gly Gln Lys Asp Ser Tyr Val Gly 
        35                  40                  45              


Asp Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys Tyr Pro Ile 
    50                  55                  60                  


Glu His Gly Ile Val Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His 
65                  70                  75                  80  


His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Val 
                85                  90                  95      


Leu Leu Thr Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met 
            100                 105                 110         


Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala 
        115                 120                 125             


Ile Gln Ala Val Leu Ser Leu Tyr Ala Ser Gly Arg Thr Thr Gly Ile 
    130                 135                 140                 


Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro Ile Tyr Glu 
145                 150                 155                 160 


Gly Tyr Ala Leu Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg 
                165                 170                 175     


Asp Leu Thr Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser 
            180                 185                 190         


Phe Thr Thr Thr Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys 
        195                 200                 205             


Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala Thr Ala Ala 
    210                 215                 220                 


Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val 
225                 230                 235                 240 


Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln 
                245                 250                 255     


Pro Ser Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe 
            260                 265                 270         


Asn Ser Ile Met Lys Cys Asp Val Asp Ile Arg Lys Asp Leu Tyr Ala 
        275                 280                 285             


Asn Thr Val Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Ile Ala Asp 
    290                 295                 300                 


Arg Met Gln Lys Glu Ile Thr Ala Leu Ala Pro Ser Thr Met Lys Ile 
305                 310                 315                 320 


Lys Ile Ile Ala Pro Pro Glu Arg Lys Tyr Ser Val Trp Ile Gly Gly 
                325                 330                 335     


Ser Ile Leu Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys 
            340                 345                 350         


Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe 
        355                 360                 365             


<210>  34
<211>  146
<212>  PRT
<213>  Mus musculus

<400>  34

Met Ala Gly Trp Gln Ser Tyr Val Asp Asn Leu Met Cys Asp Gly Cys 
1               5                   10                  15      


Cys Gln Glu Ala Ala Ile Val Gly Tyr Cys Asp Ala Lys Tyr Val Trp 
            20                  25                  30          


Ala Ala Thr Ala Gly Gly Val Phe Gln Ser Ile Thr Pro Val Glu Ile 
        35                  40                  45              


Asp Met Ile Val Gly Lys Asp Arg Glu Gly Phe Phe Thr Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Ala Lys Lys Cys Ser Val Ile Arg Asp Ser Leu Tyr Val 
65                  70                  75                  80  


Asp Gly Asp Cys Thr Met Asp Ile Arg Thr Lys Ser Gln Gly Gly Glu 
                85                  90                  95      


Pro Thr Tyr Asn Val Ala Val Gly Arg Ala Gly Arg Ala Leu Val Ile 
            100                 105                 110         


Val Met Gly Lys Glu Gly Val His Ala Gly Thr Ile Asn Lys Lys Thr 
        115                 120                 125             


Tyr Glu Leu Ala Leu Tyr Leu Lys Arg Ser Val Thr Asn Leu Tyr Leu 
    130                 135                 140                 


Ala Ser 
145     


<210>  35
<211>  199
<212>  PRT
<213>  Mus musculus

<400>  35

Met Ala Asn Arg Gly Pro Ser Tyr Gly Leu Ser Arg Glu Val Gln Glu 
1               5                   10                  15      


Lys Ile Glu Gln Lys Tyr Asp Ala Asp Leu Glu Asn Lys Leu Val Asp 
            20                  25                  30          


Trp Ile Ile Leu Gln Cys Ala Glu Asp Ile Glu His Pro Pro Pro Gly 
        35                  40                  45              


Arg Ala His Phe Gln Lys Trp Leu Met Asp Gly Thr Val Leu Cys Lys 
    50                  55                  60                  


Leu Ile Asn Ser Leu Tyr Pro Pro Gly Gln Glu Pro Ile Pro Lys Ile 
65                  70                  75                  80  


Ser Glu Ser Lys Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 
                85                  90                  95      


Leu Lys Ala Ala Glu Val Tyr Gly Val Arg Thr Thr Asp Ile Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Trp Glu Gly Lys Asp Met Ala Ala Val Gln Arg Thr 
        115                 120                 125             


Leu Met Ala Leu Gly Ser Val Ala Val Thr Lys Asp Asp Gly Cys Tyr 
    130                 135                 140                 


Arg Gly Glu Pro Ser Trp Phe His Arg Lys Ala Gln Gln Asn Arg Arg 
145                 150                 155                 160 


Gly Phe Ser Glu Glu Gln Leu Arg Gln Gly Gln Asn Val Ile Gly Leu 
                165                 170                 175     


Gln Met Gly Ser Asn Lys Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 
            180                 185                 190         


Gly Met Pro Arg Gln Ile Met 
        195                 


<210>  36
<211>  677
<212>  PRT
<213>  Mus musculus

<400>  36

Arg Val Val Ser Ala Ala Glu Pro Glu Thr Met Ala Lys Ile Ala Gln 
1               5                   10                  15      


Gly Ala Met Tyr Arg Gly Ser Val His Asp Phe Pro Glu Phe Asp Ala 
            20                  25                  30          


Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala Met Lys Gly Phe Gly Ser 
        35                  40                  45              


Asp Lys Glu Ser Ile Leu Glu Leu Ile Thr Ser Arg Ser Asn Lys Gln 
    50                  55                  60                  


Arg Gln Glu Ile Cys Gln Asn Tyr Lys Ser Leu Tyr Gly Lys Asp Leu 
65                  70                  75                  80  


Ile Glu Asp Leu Lys Tyr Glu Leu Thr Gly Lys Phe Glu Arg Leu Ile 
                85                  90                  95      


Val Asn Leu Met Arg Pro Leu Ala Tyr Cys Asp Ala Lys Glu Ile Lys 
            100                 105                 110         


Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu Lys Cys Leu Ile Glu Ile 
        115                 120                 125             


Leu Ala Ser Arg Thr Asn Glu Gln Met His Gln Leu Val Ala Ala Tyr 
    130                 135                 140                 


Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ser Asp Ile Ile Gly Asp Thr 
145                 150                 155                 160 


Ser Gly His Phe Gln Lys Met Leu Val Val Leu Leu Gln Gly Thr Arg 
                165                 170                 175     


Glu Asn Asp Asp Val Val Ser Glu Asp Leu Val Gln Gln Asp Val Gln 
            180                 185                 190         


Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Ala Gln 
        195                 200                 205             


Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys Gln His Leu Arg Leu Val 
    210                 215                 220                 


Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys Pro Ile Glu Ala Ser Ile 
225                 230                 235                 240 


Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys Leu Met Leu Ala Val Val 
                245                 250                 255     


Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe Ala Glu Arg Leu Phe Lys 
            260                 265                 270         


Ala Met Lys Gly Leu Gly Thr Arg Asp Asn Thr Leu Ile Arg Ile Met 
        275                 280                 285             


Val Ser Arg Ser Glu Leu Asp Met Leu Asp Ile Arg Glu Ile Phe Arg 
    290                 295                 300                 


Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met Ile Lys Asn Asp Thr Ser 
305                 310                 315                 320 


Gly Glu Tyr Lys Lys Ala Leu Leu Lys Leu Cys Gly Gly Asp Asp Asp 
                325                 330                 335     


Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala Gln Val Ala Tyr Gln Met 
            340                 345                 350         


Trp Glu Leu Ser Ala Val Ser Arg Val Glu Leu Lys Gly Thr Val Cys 
        355                 360                 365             


Ala Ala Asn Asp Phe Asn Pro Asp Ala Asp Ala Lys Ala Leu Arg Lys 
    370                 375                 380                 


Ala Met Lys Gly Ile Gly Thr Asp Glu Ala Thr Ile Ile Asp Ile Val 
385                 390                 395                 400 


Thr His Arg Ser Asn Ala Gln Arg Gln Gln Ile Arg Gln Thr Phe Lys 
                405                 410                 415     


Ser His Phe Gly Arg Asp Leu Met Ala Asp Leu Lys Ser Glu Ile Ser 
            420                 425                 430         


Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu Met Met Pro Pro Ala His 
        435                 440                 445             


Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met Glu Gly Ala Gly Thr Asp 
    450                 455                 460                 


Glu Lys Thr Leu Ile Glu Ile Leu Ala Thr Arg Thr Asn Ala Glu Ile 
465                 470                 475                 480 


Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp Tyr His Lys Ser Leu Glu 
                485                 490                 495     


Asp Ala Leu Ser Ser Asp Thr Ser Gly His Phe Arg Arg Ile Leu Ile 
            500                 505                 510         


Ser Leu Ala Thr Gly Asn Arg Glu Glu Gly Gly Glu Asn Arg Asp Gln 
        515                 520                 525             


Ala Gln Glu Asp Ala Gln Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys 
    530                 535                 540                 


Thr Ser Leu Glu Thr Arg Phe Met Thr Val Leu Cys Thr Arg Ser Tyr 
545                 550                 555                 560 


Pro His Leu Arg Arg Val Phe Gln Glu Phe Ile Lys Lys Thr Asn Tyr 
                565                 570                 575     


Asp Ile Glu His Val Ile Lys Lys Glu Met Ser Gly Asp Val Lys Asp 
            580                 585                 590         


Ala Phe Val Ala Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe 
        595                 600                 605             


Ala Asp Lys Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys 
    610                 615                 620                 


Thr Leu Thr Arg Val Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn 
625                 630                 635                 640 


Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala 
                645                 650                 655     


Ile Glu Gly Asp Thr Ser Gly Asp Phe Met Lys Ala Leu Leu Ala Leu 
            660                 665                 670         


Cys Gly Gly Glu Asp 
        675         


<210>  37
<211>  501
<212>  PRT
<213>  Mus musculus

<400>  37

Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ala Ser Ser Tyr Arg 
1               5                   10                  15      


Lys Val Phe Gly Asp Ser Ser Arg Leu Ser Ala Arg Leu Ser Gly Pro 
            20                  25                  30          


Gly Gly Ser Gly Ser Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val 
        35                  40                  45              


Ala Ser Thr Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu 
    50                  55                  60                  


Ala Tyr Arg Arg Leu Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala 
65                  70                  75                  80  


Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu 
                85                  90                  95      


Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val 
            100                 105                 110         


His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala 
        115                 120                 125             


Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln 
    130                 135                 140                 


Arg Glu Leu Arg Glu Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala 
145                 150                 155                 160 


Arg Ala Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln 
                165                 170                 175     


Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala 
            180                 185                 190         


Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu 
        195                 200                 205             


Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Ala Val 
                245                 250                 255     


Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr 
            260                 265                 270         


Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys 
        275                 280                 285             


Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala 
    290                 295                 300                 


Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln 
305                 310                 315                 320 


Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu 
                325                 330                 335     


Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala 
            340                 345                 350         


Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Ser Asp Leu Arg Asn Thr 
        355                 360                 365             


Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn 
    370                 375                 380                 


Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Glu Thr Arg Phe Ser Thr Gly Gly Leu Ser Ile Ser Gly 
                405                 410                 415     


Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu 
            420                 425                 430         


Ser Ser Thr Ala Ser Lys Val Ser Ser Ala Gly Leu Ser Leu Lys Lys 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Ala Ser Lys Glu Val Ser Lys Lys 
    450                 455                 460                 


Thr Ser Lys Val Gly Glu Gly Phe Glu Glu Thr Leu Gly Glu Ala Val 
465                 470                 475                 480 


Ile Ser Thr Lys Lys Thr Gly Lys Ser Ala Thr Glu Glu Ser Thr Ser 
                485                 490                 495     


Ser Ser Gln Lys Met 
            500     


<210>  38
<211>  543
<212>  PRT
<213>  Mus musculus

<400>  38

Met Ser Ser Phe Gly Tyr Asp Pro Tyr Phe Ser Thr Ser Tyr Lys Arg 
1               5                   10                  15      


Arg Tyr Val Glu Thr Pro Arg Val His Ile Ser Ser Val Arg Ser Gly 
            20                  25                  30          


Tyr Ser Thr Ala Arg Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser 
        35                  40                  45              


Ser Ser Leu Ser Val Arg Arg Ser Tyr Ser Ser Ser Ser Gly Ser Leu 
    50                  55                  60                  


Met Pro Ser Leu Glu Asn Leu Asp Leu Ser Gln Val Ala Ala Ile Ser 
65                  70                  75                  80  


Asn Asp Leu Lys Ser Ile Arg Thr Gln Glu Lys Ala Gln Leu Gln Asp 
                85                  90                  95      


Leu Asn Asp Arg Phe Ala Ser Phe Ile Glu Arg Val His Glu Leu Glu 
            100                 105                 110         


Gln Gln Asn Lys Val Leu Glu Ala Glu Leu Leu Val Leu Arg Gln Lys 
        115                 120                 125             


His Ser Glu Pro Ser Arg Phe Arg Ala Leu Tyr Glu Gln Glu Ile Arg 
    130                 135                 140                 


Asp Leu Arg Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys Gln Ala Leu 
145                 150                 155                 160 


Gln Gly Glu Arg Glu Gly Leu Glu Glu Thr Leu Arg Asn Leu Gln Ala 
                165                 170                 175     


Arg Tyr Glu Glu Glu Val Leu Ser Arg Glu Asp Ala Glu Gly Arg Leu 
            180                 185                 190         


Met Glu Ala Arg Lys Gly Ala Asp Glu Ala Ala Leu Ala Arg Ala Glu 
        195                 200                 205             


Leu Glu Lys Arg Ile Asp Ser Leu Met Asp Glu Ile Ala Phe Leu Lys 
    210                 215                 220                 


Lys Val His Glu Glu Glu Ile Ala Glu Leu Gln Ala Gln Ile Gln Tyr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Glu Met Asp Val Ser Ser Lys Pro Asp Leu Ser 
                245                 250                 255     


Ala Ala Leu Lys Asp Ile Arg Ala Gln Tyr Glu Lys Leu Ala Ala Lys 
            260                 265                 270         


Asn Met Gln Asn Ala Glu Glu Trp Phe Lys Ser Arg Phe Thr Val Leu 
        275                 280                 285             


Thr Glu Ser Ala Ala Lys Asn Thr Asp Ala Val Arg Ala Ala Lys Asp 
    290                 295                 300                 


Glu Val Ser Glu Ser Arg Arg Leu Leu Lys Ala Lys Thr Leu Glu Ile 
305                 310                 315                 320 


Glu Ala Cys Arg Gly Met Asn Glu Ala Leu Glu Lys Gln Leu Gln Glu 
                325                 330                 335     


Leu Glu Asp Lys Gln Asn Ala Asp Ile Ser Ala Met Gln Asp Thr Ile 
            340                 345                 350         


Asn Lys Leu Glu Asn Glu Leu Arg Ser Thr Lys Ser Glu Met Ala Arg 
        355                 360                 365             


Tyr Leu Lys Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp 
    370                 375                 380                 


Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg 
385                 390                 395                 400 


Leu Ser Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser 
                405                 410                 415     


Ser Gln Val Phe Gly Arg Ser Ala Tyr Ser Gly Leu Gln Ser Ser Ser 
            420                 425                 430         


Tyr Leu Met Ser Ala Arg Ser Phe Pro Ala Tyr Tyr Thr Ser His Val 
        435                 440                 445             


Gln Glu Glu Gln Thr Glu Val Glu Glu Thr Ile Glu Ala Thr Lys Ala 
    450                 455                 460                 


Glu Glu Ala Lys Asp Glu Pro Pro Ser Glu Gly Glu Ala Glu Glu Glu 
465                 470                 475                 480 


Glu Lys Glu Lys Glu Glu Gly Glu Glu Glu Glu Gly Ala Glu Glu Glu 
                485                 490                 495     


Glu Ala Ala Lys Asp Glu Ser Glu Asp Thr Lys Glu Glu Glu Glu Gly 
            500                 505                 510         


Gly Glu Gly Glu Glu Glu Asp Thr Lys Glu Ser Glu Glu Glu Glu Lys 
        515                 520                 525             


Lys Glu Glu Ser Ala Gly Glu Glu Gln Val Ala Lys Lys Lys Asp 
    530                 535                 540             


<210>  39
<211>  400
<212>  PRT
<213>  Mus musculus

<400>  39

Met Pro Arg Phe Ser Leu Ser Arg Met Thr Pro Pro Leu Pro Ala Arg 
1               5                   10                  15      


Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu Thr 
            20                  25                  30          


Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe Ala 
        35                  40                  45              


Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala Leu 
    50                  55                  60                  


Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala 
65                  70                  75                  80  


Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln 
                85                  90                  95      


Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Phe Ala 
            100                 105                 110         


Gln Asp Leu Gly Thr Leu Arg Gln Lys Leu Gln Asp Glu Thr Asn Leu 
        115                 120                 125             


Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala Asp 
    130                 135                 140                 


Glu Ala Thr Leu Ala Arg Val Asp Leu Glu Arg Lys Val Glu Ser Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Gln Phe Leu Arg Lys Ile Tyr Glu Glu Glu Val Arg 
                165                 170                 175     


Glu Leu Arg Glu Gln Leu Ala Gln Gln Gln Val His Val Glu Met Asp 
            180                 185                 190         


Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg Thr Gln 
        195                 200                 205             


Tyr Glu Ala Val Ala Thr Ser Asn Met Gln Glu Thr Glu Glu Trp Tyr 
    210                 215                 220                 


Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ser Arg Asn Ala Glu 
225                 230                 235                 240 


Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln Leu 
                245                 250                 255     


Gln Ala Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu Ser 
            260                 265                 270         


Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg Glu Ser 
        275                 280                 285             


Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln Ser 
    290                 295                 300                 


Leu Lys Glu Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu 
305                 310                 315                 320 


Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu 
                325                 330                 335     


Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe Ser 
            340                 345                 350         


Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser Glu 
        355                 360                 365             


Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg Asp 
    370                 375                 380                 


Gly Glu Val Ile Lys Asp Ser Lys Gln Glu His Lys Asp Val Val Met 
385                 390                 395                 400 


<210>  40
<211>  451
<212>  PRT
<213>  Mus musculus

<400>  40

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  41
<211>  445
<212>  PRT
<213>  Mus musculus

<400>  41

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Asn Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu 
            420                 425                 430         


Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala 
        435                 440                 445 


<210>  42
<211>  450
<212>  PRT
<213>  Mus musculus

<400>  42

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Asp Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  43
<211>  572
<212>  PRT
<213>  Mus musculus

<400>  43

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 
65                  70                  75                  80  


Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Glu Trp 
    130                 135                 140                 


His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 
                165                 170                 175     


Thr Asp Ser Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu 
        195                 200                 205             


Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ser Ile 
225                 230                 235                 240 


Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ala Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 
            260                 265                 270         


Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 
305                 310                 315                 320 


Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ser Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 
                405                 410                 415     


Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ala Leu Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 
        435                 440                 445             


Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 
    450                 455                 460                 


Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 
            500                 505                 510         


Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 
    530                 535                 540                 


Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 
                565                 570         


<210>  44
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  44

Glu Gln Lys Arg Leu Leu Glu Gln Gly Ile Thr Gly Pro Glu Gly His 
1               5                   10                  15      


Val Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala 
            20                  25                  30          


Val Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val 
        35                  40                  45              


Met Ser Lys Gly Ala Ala Asp Met Val Ala Gln Ala Lys Arg Arg Gly 
    50                  55                  60                  


Val Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly 
65                  70                  75                  80  


Ser His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr 
                85                  90                  95      


Ser Pro Pro Ile Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Ser 
            100                 105                 110         


Leu Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr 
        115                 120                 125             


Phe Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile 
    130                 135                 140                 


Pro Glu Gly Val Asn Gly Ile Glu Glu Arg Met Ser Val Val Trp Glu 
145                 150                 155                 160 


Lys Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val 
                165                 170                 175     


Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly 
            180                 185                 190         


Arg Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Arg 
        195                 200                 205             


Ala Thr Lys Val Ile Ser Ala Lys Ser His Asn Leu Asn Val Glu Tyr 
    210                 215                 220                 


Asn Ile Phe Glu Gly Val Glu Cys Arg Gly Val Pro Thr Val Val Ile 
225                 230                 235                 240 


Ser Gln Gly Arg Val Val Leu Glu Asp Gly Asn Leu Leu Val Thr Pro 
                245                 250                 255     


Gly Ala Gly Arg Phe Ile Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr 
            260                 265                 270         


Lys Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro 
        275                 280                 285             


Arg Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Leu Pro Ala Lys 
    290                 295                 300                 


Pro Gly Ser Gly Thr Gln Ala Arg Ala Ser Cys Ser Gly Lys Ile Ser 
305                 310                 315                 320 


Val Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly 
                325                 330                 335     


Ser Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met 
            340                 345                 350         


Ala Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
        355                 360                 365 


<210>  45
<211>  226
<212>  PRT
<213>  Mus musculus

<400>  45

Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Asp Lys Asp Lys Lys Ala Glu Gly Ala Gly Thr Glu 
            20                  25                  30          


Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Asp Ala 
        35                  40                  45              


Thr Glu Val Lys Glu Ser Thr Glu Glu Lys Pro Lys Asp Ala Ala Asp 
    50                  55                  60                  


Gly Glu Ala Lys Ala Glu Glu Lys Glu Ala Asp Lys Ala Ala Ala Ala 
65                  70                  75                  80  


Lys Glu Glu Ala Pro Lys Ala Glu Pro Glu Lys Ser Glu Gly Ala Ala 
                85                  90                  95      


Glu Glu Gln Pro Glu Pro Ala Pro Ala Pro Glu Gln Glu Ala Ala Ala 
            100                 105                 110         


Pro Gly Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Gly Glu Ala Ser 
        115                 120                 125             


Ala Glu Ser Thr Gly Ala Ala Asp Gly Ala Ala Pro Glu Glu Gly Glu 
    130                 135                 140                 


Ala Lys Lys Thr Glu Ala Pro Ala Ala Ala Gly Pro Glu Ala Lys Ser 
145                 150                 155                 160 


Asp Ala Ala Pro Ala Ala Ser Asp Ser Lys Pro Ser Ser Ala Glu Pro 
                165                 170                 175     


Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Ser Glu Ala Pro Ser Ser 
            180                 185                 190         


Ala Ala Lys Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Glu Pro Gln 
        195                 200                 205             


Ala Glu Ala Pro Ala Ala Ala Ala Ser Ser Glu Gln Ser Val Ala Val 
    210                 215                 220                 


Lys Glu 
225     


<210>  46
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  46

Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
            20                  25                  30          


Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                85                  90                  95      


Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
        115                 120                 125             


Lys Val Val Asp Asn Thr Thr Ala Lys Val Ser Arg Pro Ala Leu Ala 
    130                 135                 140                 


Val Arg Gly Leu Gly Pro Thr Cys Leu His Pro Phe Ser Pro Cys Ser 
145                 150                 155                 160 


Pro Leu Ser Leu Leu Pro Phe Ala Gly Ile Cys Arg Leu Ser Gly Cys 
                165                 170                 175     


Pro Leu Pro Arg Asp Lys Cys Gln Glu Cys His Gln Cys 
            180                 185                 


<210>  47
<211>  220
<212>  PRT
<213>  Mus musculus

<400>  47

Met Ala Ser Ala Thr Asp Ser Arg Tyr Gly Gln Lys Glu Ser Ser Asp 
1               5                   10                  15      


Gln Asn Phe Asp Tyr Met Phe Lys Ile Leu Ile Ile Gly Asn Ser Ser 
            20                  25                  30          


Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
        35                  40                  45              


Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Ile 
    50                  55                  60                  


Tyr Arg Asn Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
65                  70                  75                  80  


Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                85                  90                  95      


Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
            100                 105                 110         


Val Gln Asp Trp Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
        115                 120                 125             


Gln Val Leu Leu Val Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val 
    130                 135                 140                 


Val Ser Ser Glu Arg Gly Arg Gln Leu Ala Asp His Leu Gly Phe Glu 
145                 150                 155                 160 


Phe Phe Glu Ala Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe 
                165                 170                 175     


Glu Arg Leu Val Asp Val Ile Cys Glu Lys Met Ser Glu Ser Leu Asp 
            180                 185                 190         


Thr Ala Asp Pro Ala Val Thr Gly Ala Lys Gln Gly Pro Gln Leu Thr 
        195                 200                 205             


Asp Gln Gln Ala Pro Pro His Gln Asp Cys Ala Cys 
    210                 215                 220 


<210>  48
<211>  208
<212>  PRT
<213>  Mus musculus

<400>  48

Met Ser Ala Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Val Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Val Asn Ser Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys 
    130                 135                 140                 


Ala Lys Glu Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Ser Thr Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Glu Lys Pro Gln Glu Gln Pro Val Asn Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210>  49
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  49

Met Asp Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu 
1               5                   10                  15      


Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His 
            20                  25                  30          


Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ser Ser Ile Thr Pro 
        35                  40                  45              


Leu Glu Glu Leu Tyr Lys Arg Phe Gln Ile Leu Glu Gly Pro Pro Glu 
    50                  55                  60                  


Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe 
65                  70                  75                  80  


Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val 
                85                  90                  95      


Thr Arg Tyr Leu Asp Phe Lys Val Val Glu Gly Ser Phe Val Tyr Lys 
            100                 105                 110         


Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Thr Glu Ala Leu Ala 
        115                 120                 125             


Ser Asn Leu Met Gly Met Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu 
    130                 135                 140                 


Val Phe Val Ala Asn Phe Asp Glu Asn Asp Pro Lys Thr Phe Glu Gly 
145                 150                 155                 160 


Val Asp Pro Gln Asn Thr Ser Met Arg Asp Val Tyr Arg Lys Phe Asp 
                165                 170                 175     


Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr 
            180                 185                 190         


Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Leu Glu Thr Ile Asn Arg 
        195                 200                 205             


Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr 
    210                 215                 220                 


Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg 
225                 230                 235                 240 


Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Val Asp 
                245                 250                 255     


Asp Ile Ile Met Glu Asn Gly Lys Val Val Gly Val Lys Ser Glu Gly 
            260                 265                 270         


Glu Val Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Ile Pro 
        275                 280                 285             


Asp Arg Val Gln Lys Ala Gly Gln Val Ile Arg Ile Ile Cys Ile Leu 
    290                 295                 300                 


Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile 
305                 310                 315                 320 


Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met 
                325                 330                 335     


Ile Ser Tyr Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile 
            340                 345                 350         


Ala Ser Thr Thr Val Glu Thr Ala Glu Pro Glu Lys Glu Val Glu Pro 
        355                 360                 365             


Ala Leu Glu Leu Leu Glu Pro Ile Asp Gln Lys Phe Val Ala Ile Ser 
    370                 375                 380                 


Asp Leu Tyr Glu Pro Ile Asp Asp Gly Ser Glu Ser Gln Val Phe Cys 
385                 390                 395                 400 


Ser Cys Ser Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asn Asp 
                405                 410                 415     


Ile Lys Asp Ile Tyr Lys Arg Met Ala Gly Ser Ala Phe Asp Phe Glu 
            420                 425                 430         


Asn Met Lys Arg Lys Gln Asn Asp Val Phe Gly Glu Ala Asp Gln 
        435                 440                 445         


<210>  50
<211>  298
<212>  PRT
<213>  Mus musculus

<400>  50

Met Asp Asn Ala Gly Lys Glu Arg Glu Ala Val Gln Leu Met Ala Glu 
1               5                   10                  15      


Ala Glu Lys Arg Val Lys Ala Ser His Ser Phe Leu Arg Gly Leu Phe 
            20                  25                  30          


Gly Gly Asn Thr Arg Ile Glu Glu Ala Cys Glu Met Tyr Thr Arg Ala 
        35                  40                  45              


Ala Asn Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala 
    50                  55                  60                  


Phe Cys Gln Ala Ala Lys Leu His Met Gln Leu Gln Ser Lys His Asp 
65                  70                  75                  80  


Ser Ala Thr Ser Phe Val Asp Ala Gly Asn Ala Tyr Lys Lys Ala Asp 
                85                  90                  95      


Pro Gln Glu Ala Ile Asn Cys Leu Asn Ala Ala Ile Asp Ile Tyr Thr 
            100                 105                 110         


Asp Met Gly Arg Phe Thr Ile Ala Ala Lys His His Ile Thr Ile Ala 
        115                 120                 125             


Glu Ile Tyr Glu Thr Glu Leu Val Asp Ile Glu Lys Ala Ile Ala His 
    130                 135                 140                 


Tyr Glu Gln Ser Ala Asp Tyr Tyr Lys Gly Glu Glu Ser Asn Ser Ser 
145                 150                 155                 160 


Ala Asn Lys Cys Leu Leu Lys Val Ala Ala Tyr Ala Ala Gln Leu Glu 
                165                 170                 175     


Gln Tyr Gln Lys Ala Ile Glu Ile Tyr Glu Gln Val Gly Ala Asn Thr 
            180                 185                 190         


Met Asp Asn Pro Leu Leu Lys Tyr Ser Ala Lys Asp Tyr Phe Phe Lys 
        195                 200                 205             


Ala Ala Leu Cys His Phe Ile Val Asp Glu Leu Asn Ala Lys Leu Ala 
    210                 215                 220                 


Leu Glu Lys Tyr Glu Glu Met Phe Pro Ala Phe Thr Asp Ser Arg Glu 
225                 230                 235                 240 


Cys Lys Leu Leu Lys Lys Leu Leu Glu Ala His Glu Glu Gln Asn Ser 
                245                 250                 255     


Glu Ala Tyr Thr Glu Ala Val Lys Glu Phe Asp Ser Ile Ser Arg Leu 
            260                 265                 270         


Asp Gln Trp Leu Thr Thr Met Leu Leu Arg Ile Lys Lys Ser Ile Gln 
        275                 280                 285             


Gly Asp Gly Glu Gly Asp Gly Asp Leu Lys 
    290                 295             


<210>  51
<211>  504
<212>  PRT
<213>  Mus musculus

<400>  51

Met Arg Phe Ser Cys Leu Ala Leu Leu Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Glu Asn Phe Glu Ser Arg Val Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Ile Val Pro Leu Ala 
65                  70                  75                  80  


Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly Val 
                85                  90                  95      


Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Ala Gly Glu Glu Ala Gly 
            100                 105                 110         


Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu Lys 
        115                 120                 125             


Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu Phe 
    130                 135                 140                 


Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Val Val Gly Phe Phe Arg 
145                 150                 155                 160 


Asp Leu Phe Ser Asp Gly His Ser Glu Phe Leu Lys Ala Ala Ser Asn 
                165                 170                 175     


Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Ile Glu Ser Leu Val 
            180                 185                 190         


Lys Glu Tyr Asp Asp Asn Gly Glu Gly Ile Thr Ile Phe Arg Pro Leu 
        195                 200                 205             


His Leu Ala Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu Lys 
    210                 215                 220                 


Lys Met Thr Ser Ala Lys Ile Lys Lys Phe Ile Gln Asp Ser Ile Phe 
225                 230                 235                 240 


Gly Leu Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln Gly 
                245                 250                 255     


Lys Asp Leu Leu Thr Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn Ala 
            260                 265                 270         


Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys Lys 
        275                 280                 285             


Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg Lys 
    290                 295                 300                 


Thr Phe Ser His Glu Leu Ser Asp Phe Ser Leu Glu Ser Thr Thr Gly 
305                 310                 315                 320 


Glu Val Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe Val 
                325                 330                 335     


Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Gln Phe Leu 
            340                 345                 350         


Gln Glu Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu Pro 
        355                 360                 365             


Ile Pro Glu Ser Asn Glu Gly Pro Val Lys Val Val Val Ala Glu Asn 
    370                 375                 380                 


Phe Asp Asp Ile Val Asn Glu Glu Asp Lys Asp Val Leu Ile Glu Phe 
385                 390                 395                 400 


Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr Lys 
                405                 410                 415     


Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala Lys 
            420                 425                 430         


Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Lys Gly 
        435                 440                 445             


Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Thr Pro Lys 
    450                 455                 460                 


Lys Tyr Glu Gly Gly Arg Glu Leu Asn Asp Phe Ile Ser Tyr Leu Gln 
465                 470                 475                 480 


Arg Glu Ala Thr Asn Pro Pro Ile Ile Gln Glu Glu Lys Pro Lys Lys 
                485                 490                 495     


Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 


<210>  52
<211>  157
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Met Val Asp Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys 
1               5                   10                  15      


Leu Asp Leu Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser 
            20                  25                  30          


Leu Pro Glu Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile 
        35                  40                  45              


Phe Asp Thr Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu 
    50                  55                  60                  


Gly Val Ser Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg 
65                  70                  75                  80  


Phe Ala Phe Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn 
                85                  90                  95      


Gly Glu Leu Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys 
            100                 105                 110         


Asp Thr Gln Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp 
        115                 120                 125             


Lys Asp Gly Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val 
    130                 135                 140                 


Gly Gly Leu Asp Ile His Lys Lys Met Val Val Asp Val 
145                 150                 155         


<210>  53
<211>  261
<212>  PRT
<213>  Mus musculus

<400>  53

Met Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe 
1               5                   10                  15      


Phe Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu 
            20                  25                  30          


Gly Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Leu Gln Ala Arg Lys 
        35                  40                  45              


Lys Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Ser Phe Val Asp Gln 
    50                  55                  60                  


Tyr Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His 
65                  70                  75                  80  


Val Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln 
                85                  90                  95      


Leu Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr 
            100                 105                 110         


Asp His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys 
        115                 120                 125             


Asp Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala 
    130                 135                 140                 


Glu Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly 
145                 150                 155                 160 


Lys Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn 
                165                 170                 175     


Phe Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn 
            180                 185                 190         


Lys Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu 
        195                 200                 205             


Asn Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln 
    210                 215                 220                 


Glu Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala 
225                 230                 235                 240 


Leu Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu 
                245                 250                 255     


Ser Ala Gly Asp Asn 
            260     


<210>  54
<211>  190
<212>  PRT
<213>  Mus musculus

<400>  54

Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu Asn 
1               5                   10                  15      


Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe Met 
            20                  25                  30          


Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu Ala 
        35                  40                  45              


Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn Arg 
    50                  55                  60                  


Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu Arg 
65                  70                  75                  80  


Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met Ser 
                85                  90                  95      


Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly Met 
            100                 105                 110         


Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp Lys 
        115                 120                 125             


Asp Gly Ser Gly Tyr Ile Asp Glu Asn Glu Leu Asp Ala Leu Leu Lys 
    130                 135                 140                 


Asp Leu Tyr Glu Lys Asn Lys Lys Glu Met Asn Ile Gln Gln Leu Thr 
145                 150                 155                 160 


Thr Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu Tyr 
                165                 170                 175     


Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Val 
            180                 185                 190 


<210>  55
<211>  191
<212>  PRT
<213>  Mus musculus

<400>  55

Met Gly Lys Gln Asn Ser Lys Leu Ala Pro Glu Val Met Glu Asp Leu 
1               5                   10                  15      


Val Lys Ser Thr Glu Phe Asn Glu His Glu Leu Lys Gln Trp Tyr Lys 
            20                  25                  30          


Gly Phe Leu Lys Asp Cys Pro Ser Gly Arg Leu Asn Leu Glu Glu Phe 
        35                  40                  45              


Gln Gln Leu Tyr Val Lys Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
    50                  55                  60                  


Ala Gln His Ala Phe Arg Thr Phe Asp Lys Asn Gly Asp Gly Thr Ile 
65                  70                  75                  80  


Asp Phe Arg Glu Phe Ile Cys Ala Leu Ser Ile Thr Ser Arg Gly Ser 
                85                  90                  95      


Phe Glu Gln Lys Leu Asn Trp Ala Phe Asn Met Tyr Asp Leu Asp Gly 
            100                 105                 110         


Asp Gly Lys Ile Thr Arg Val Glu Met Leu Glu Ile Ile Glu Ala Ile 
        115                 120                 125             


Tyr Lys Met Val Gly Thr Val Ile Met Met Lys Met Asn Glu Asp Gly 
    130                 135                 140                 


Leu Thr Pro Glu Gln Arg Val Asp Lys Ile Phe Ser Lys Met Asp Lys 
145                 150                 155                 160 


Asn Lys Asp Asp Gln Ile Thr Leu Asp Glu Phe Lys Glu Ala Ala Lys 
                165                 170                 175     


Ser Asp Pro Ser Ile Val Leu Leu Leu Gln Cys Asp Ile Gln Lys 
            180                 185                 190     


<210>  56
<211>  253
<212>  PRT
<213>  Mus musculus

<400>  56

Met Ala Leu Ser Met Pro Leu Asn Gly Leu Lys Glu Glu Asp Lys Glu 
1               5                   10                  15      


Pro Leu Ile Glu Leu Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile 
            20                  25                  30          


Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp Leu Lys 
        35                  40                  45              


Gly Val Val Phe Ser Val Thr Thr Val Asp Leu Lys Arg Lys Pro Ala 
    50                  55                  60                  


Asp Leu Gln Asn Leu Ala Pro Gly Thr His Pro Pro Phe Ile Thr Phe 
65                  70                  75                  80  


Asn Ser Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe Leu Glu 
                85                  90                  95      


Glu Val Leu Cys Pro Pro Lys Tyr Leu Lys Leu Ser Pro Lys His Pro 
            100                 105                 110         


Glu Ser Asn Thr Ala Gly Met Asp Ile Phe Ala Lys Phe Ser Ala Tyr 
        115                 120                 125             


Ile Lys Asn Ser Arg Pro Glu Ala Asn Glu Ala Leu Glu Arg Gly Leu 
    130                 135                 140                 


Leu Lys Thr Leu Gln Lys Leu Asp Glu Tyr Leu Asn Ser Pro Leu Pro 
145                 150                 155                 160 


Asp Glu Ile Asp Glu Asn Ser Met Glu Asp Ile Lys Phe Ser Thr Arg 
                165                 170                 175     


Arg Phe Leu Asp Gly Asp Glu Met Thr Leu Ala Asp Cys Asn Leu Leu 
            180                 185                 190         


Pro Lys Leu His Ile Val Lys Val Val Ala Lys Lys Tyr Arg Asn Phe 
        195                 200                 205             


Asp Ile Pro Lys Gly Met Thr Gly Ile Trp Arg Tyr Leu Thr Asn Ala 
    210                 215                 220                 


Tyr Ser Arg Asp Glu Phe Thr Asn Thr Cys Pro Ser Asp Lys Glu Val 
225                 230                 235                 240 


Glu Ile Ala Tyr Ser Asp Val Ala Lys Arg Leu Thr Lys 
                245                 250             


<210>  57
<211>  187
<212>  PRT
<213>  Mus musculus

<400>  57

Met Ala Ala Asp Ile Ser Gln Trp Ala Gly Pro Leu Cys Leu Gln Glu 
1               5                   10                  15      


Val Asp Glu Pro Pro Gln His Ala Leu Arg Val Asp Tyr Ala Gly Val 
            20                  25                  30          


Thr Val Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Met Asn 
        35                  40                  45              


Arg Pro Ser Ser Ile Ser Trp Asp Gly Leu Asp Pro Gly Lys Leu Tyr 
    50                  55                  60                  


Thr Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys 
65                  70                  75                  80  


Phe Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp 
                85                  90                  95      


Ile Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro 
            100                 105                 110         


Ser Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Glu 
        115                 120                 125             


Gln Pro Leu Ser Cys Asp Glu Pro Ile Leu Ser Asn Lys Ser Gly Asp 
    130                 135                 140                 


Asn Arg Gly Lys Phe Lys Val Glu Thr Phe Arg Lys Lys Tyr Asn Leu 
145                 150                 155                 160 


Gly Ala Pro Ala Ala Gly Thr Cys Tyr Gln Ala Lys Trp Asp Asp Tyr 
                165                 170                 175     


Val Pro Lys Leu Tyr Lys Gln Leu Ser Gly Lys 
            180                 185         


<210>  58
<211>  256
<212>  PRT
<213>  Mus musculus

<400>  58

Gly Arg Phe Leu Gln Pro Glu Glu Tyr Pro Val Met Asp Lys Asn Glu 
1               5                   10                  15      


Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala Glu Arg Tyr Asp Asp 
            20                  25                  30          


Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln Gly Ala Glu Leu Ser 
        35                  40                  45              


Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Val Gly 
    50                  55                  60                  


Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser Ile Glu Gln Lys Thr 
65                  70                  75                  80  


Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg Glu Tyr Arg Glu Lys 
                85                  90                  95      


Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp Val Leu Ser Leu Leu 
            100                 105                 110         


Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Pro Glu Ser Lys Val Phe 
        115                 120                 125             


Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala 
    130                 135                 140                 


Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln Ser Gln Gln Ala Tyr 
145                 150                 155                 160 


Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met Gln Pro Thr His Pro 
                165                 170                 175     


Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val Phe Tyr Tyr Glu Ile 
            180                 185                 190         


Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala Lys Thr Ala Phe Asp 
        195                 200                 205             


Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu Glu Ser Tyr Lys Asp 
    210                 215                 220                 


Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr 
225                 230                 235                 240 


Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly Glu Gly Gly Glu Asn 
                245                 250                 255     


<210>  59
<211>  175
<212>  PRT
<213>  Mus musculus

<400>  59

Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
1               5                   10                  15      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            20                  25                  30          


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        35                  40                  45              


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    50                  55                  60                  


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
65                  70                  75                  80  


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                85                  90                  95      


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            100                 105                 110         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        115                 120                 125             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    130                 135                 140                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
145                 150                 155                 160 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                165                 170                 175 


<210>  60
<211>  199
<212>  PRT
<213>  Mus musculus

<400>  60

Met Ser Ser Gly Asn Ala Lys Ile Gly Tyr Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Glu Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Asp 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Ile Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Ile Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Ile 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ile Ile Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Asn Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  61
<211>  257
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ala Ala Ala Ala Gly Arg Leu Leu Trp Ser Ser Val Ala Arg His 
1               5                   10                  15      


Ala Ser Ala Ile Ser Arg Ser Ile Ser Ala Ser Thr Val Leu Arg Pro 
            20                  25                  30          


Val Ala Ser Arg Arg Thr Cys Leu Thr Asp Ile Leu Trp Ser Ala Ser 
        35                  40                  45              


Ala Gln Gly Lys Ser Ala Phe Ser Thr Ser Ser Ser Phe His Thr Pro 
    50                  55                  60                  


Ala Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn 
65                  70                  75                  80  


Gly Glu Phe Lys Glu Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu 
                85                  90                  95      


Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu 
            100                 105                 110         


Ile Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys 
        115                 120                 125             


Glu Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp 
    130                 135                 140                 


Ile Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Thr 
145                 150                 155                 160 


Leu Leu Ser Asp Ile Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu 
                165                 170                 175     


Leu Glu Ser Ala Gly Ile Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro 
            180                 185                 190         


Asn Gly Val Val Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg 
        195                 200                 205             


Ser Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Phe Val Glu 
    210                 215                 220                 


Thr His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Glu Ser Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Ser Pro Thr Ala Ser Lys Glu Tyr Phe Glu Lys Val His 
                245                 250                 255     


Gln 
    


<210>  62
<211>  312
<212>  PRT
<213>  Mus musculus

<400>  62

Met Glu Gly Glu Cys Arg Val Leu Ser Ile Gln Ser His Val Val Arg 
1               5                   10                  15      


Gly Tyr Val Gly Asn Arg Ala Ala Met Phe Pro Leu Gln Val Leu Gly 
            20                  25                  30          


Phe Glu Val Asp Ala Val Asn Ser Val Gln Phe Ser Asn His Thr Gly 
        35                  40                  45              


Tyr Ala His Trp Lys Gly Gln Val Leu Lys Ser Gln Glu Leu His Glu 
    50                  55                  60                  


Leu Tyr Glu Gly Leu Lys Val Asn Asp Val Asn Lys Tyr Asp Tyr Val 
65                  70                  75                  80  


Leu Thr Gly Tyr Thr Arg Asp Lys Ser Phe Leu Ala Met Val Val Asp 
                85                  90                  95      


Ile Val Arg Glu Leu Lys Gln Gln Asn Ser Arg Leu Val Tyr Val Cys 
            100                 105                 110         


Asp Pro Val Met Gly Asp Lys Trp Asn Gly Glu Gly Ser Met Tyr Val 
        115                 120                 125             


Pro Gln Asp Leu Leu Pro Val Tyr Arg Asp Lys Val Val Pro Val Ala 
    130                 135                 140                 


Asp Ile Ile Thr Pro Asn Gln Phe Glu Ala Glu Leu Leu Ser Gly Arg 
145                 150                 155                 160 


Lys Ile His Ser Gln Glu Glu Ala Phe Glu Val Met Asp Met Leu His 
                165                 170                 175     


Cys Met Gly Pro Asp Thr Val Val Ile Thr Ser Ser Asp Leu Pro Ser 
            180                 185                 190         


Ser Gln Gly Ser Asp Tyr Leu Ile Ala Leu Gly Ser Gln Arg Met Arg 
        195                 200                 205             


Lys Pro Asp Gly Ser Thr Val Thr Gln Arg Ile Arg Met Glu Met Arg 
    210                 215                 220                 


Lys Val Glu Ala Val Phe Val Gly Thr Gly Asp Leu Phe Ala Ala Met 
225                 230                 235                 240 


Leu Leu Ala Trp Thr His Lys His Pro Asp Asn Leu Lys Val Ala Cys 
                245                 250                 255     


Glu Lys Thr Val Ser Ala Met Gln His Val Leu Gln Arg Thr Ile Arg 
            260                 265                 270         


Cys Ala Lys Ala Glu Ala Gly Glu Gly Gln Lys Pro Ser Pro Ala Gln 
        275                 280                 285             


Leu Glu Leu Arg Met Val Gln Ser Lys Arg Asp Ile Glu Asp Pro Glu 
    290                 295                 300                 


Ile Val Val Gln Ala Thr Val Leu 
305                 310         


<210>  63
<211>  354
<212>  PRT
<213>  Mus musculus

<400>  63

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Val Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Thr Asp Ser Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Gly Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Lys Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Ile Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Ser Ala Phe Thr Glu Ala Val Ala His Ile 
    290                 295                 300                 


Gln Gly Gln Tyr Glu Ser Lys Asn Lys Ser Ala His Lys Glu Val Tyr 
305                 310                 315                 320 


Ser His Val Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Ala Lys Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  64
<211>  2199
<212>  DNA
<213>  Homo sapiens

<400>  64
gggacaaact tttcccaaac ccgatccgag cccttggacc aaactcgcct gcgccgagag       60

ccgtccgcgt agagcgctcc gtctccggcg agatgtccga gcgcaaagaa ggcagaggca      120

aagggaaggg caagaagaag gagcgaggct ccggcaagaa gccggagtcc gcggcgggca      180

gccagagccc agccttgcct ccccaattga aagagatgaa aagccaggaa tcggctgcag      240

gttccaaact agtccttcgg tgtgaaacca gttctgaata ctcctctctc agattcaagt      300

ggttcaagaa tgggaatgaa ttgaatcgaa aaaacaaacc acaaaatatc aagatacaaa      360

aaaagccagg gaagtcagaa cttcgcatta acaaagcatc actggctgat tctggagagt      420

atatgtgcaa agtgatcagc aaattaggaa atgacagtgc ctctgccaat atcaccatcg      480

tggaatcaaa cgagatcatc actggtatgc cagcctcaac tgaaggagca tatgtgtctt      540

cagagtctcc cattagaata tcagtatcca cagaaggagc aaatacttct tcatctacat      600

ctacatccac cactgggaca agccatcttg taaaatgtgc ggagaaggag aaaactttct      660

gtgtgaatgg aggggagtgc ttcatggtga aagacctttc aaacccctcg agatacttgt      720

gcaagtgccc aaatgagttt actggtgatc gctgccaaaa ctacgtaatg gccagcttct      780

acaagcatct tgggattgaa tttatggagg cggaggagct gtaccagaag agagtgctga      840

ccataaccgg catctgcatc gccctccttg tggtcggcat catgtgtgtg gtggcctact      900

gcaaaaccaa gaaacagcgg aaaaagctgc atgaccgtct tcggcagagc cttcggtctg      960

aacgaaacaa tatgatgaac attgccaatg ggcctcacca tcctaaccca ccccccgaga     1020

atgtccagct ggtgaatcaa tacgtatcta aaaacgtcat ctccagtgag catattgttg     1080

agagagaagc agagacatcc ttttccacca gtcactatac ttccacagcc catcactcca     1140

ctactgtcac ccagactcct agccacagct ggagcaacgg acacactgaa agcatccttt     1200

ccgaaagcca ctctgtaatc gtgatgtcat ccgtagaaaa cagtaggcac agcagcccaa     1260

ctgggggccc aagaggacgt cttaatggca caggaggccc tcgtgaatgt aacagcttcc     1320

tcaggcatgc cagagaaacc cctgattcct accgagactc tcctcatagt gaaaggtatg     1380

tgtcagccat gaccaccccg gctcgtatgt cacctgtaga tttccacacg ccaagctccc     1440

ccaaatcgcc cccttcggaa atgtctccac ccgtgtccag catgacggtg tccatgcctt     1500

ccatggcggt cagccccttc atggaagaag agagacctct acttctcgtg acaccaccaa     1560

ggctgcggga gaagaagttt gaccatcacc ctcagcagtt cagctccttc caccacaacc     1620

ccgcgcatga cagtaacagc ctccctgcta gccccttgag gatagtggag gatgaggagt     1680

atgaaacgac ccaagagtac gagccagccc aagagcctgt taagaaactc gccaatagcc     1740

ggcgggccaa aagaaccaag cccaatggcc acattgctaa cagattggaa gtggacagca     1800

acacaagctc ccagagcagt aactcagaga gtgaaacaga agatgaaaga gtaggtgaag     1860

atacgccttt cctgggcata cagaaccccc tggcagccag tcttgaggca acacctgcct     1920

tccgcctggc tgacagcagg actaacccag caggccgctt ctcgacacag gaagaaatcc     1980

aggccaggct gtctagtgta attgctaacc aagaccctat tgctgtataa aacctaaata     2040

aacacataga ttcacctgta aaactttatt ttatataata aagtattcca ccttaaatta     2100

aacaatttat tttattttag cagttctgca aatagaaaac aggaaaaaaa cttttataaa     2160

ttaaatatat gtatgtaaaa atgaaaaaaa aaaaaaaaa                            2199


<210>  65
<211>  299
<212>  PRT
<213>  Mus musculus

<400>  65

Met Glu Gly Lys Ala Glu Gln Gln Gly Ala Gly Leu Thr Met Ala Glu 
1               5                   10                  15      


Gly Gly Glu Lys Glu Glu Phe Cys Phe Thr Ala Ile Tyr Ile Ser Gly 
            20                  25                  30          


Gln Trp Arg Glu Pro Cys Val Cys Thr Asp Leu Gln Arg Leu Glu Pro 
        35                  40                  45              


Gly Thr Met Ala Pro Thr Arg Lys Phe Phe Val Gly Gly Asn Trp Lys 
    50                  55                  60                  


Met Asn Gly Arg Lys Lys Cys Leu Gly Glu Leu Ile Cys Thr Leu Asn 
65                  70                  75                  80  


Ala Ala Asn Val Pro Ala Gly Thr Glu Val Val Cys Ala Pro Pro Thr 
                85                  90                  95      


Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val 
            100                 105                 110         


Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu 
        115                 120                 125             


Ile Ser Pro Gly Met Ile Lys Asp Leu Gly Ala Thr Trp Val Val Leu 
    130                 135                 140                 


Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile 
145                 150                 155                 160 


Gly Gln Lys Val Ser His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala 
                165                 170                 175     


Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys 
            180                 185                 190         


Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp 
        195                 200                 205             


Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly 
    210                 215                 220                 


Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg 
225                 230                 235                 240 


Gly Trp Leu Lys Ser Asn Val Asn Asp Gly Val Ala Gln Ser Thr Arg 
                245                 250                 255     


Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala 
            260                 265                 270         


Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys 
        275                 280                 285             


Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln 
    290                 295                 


<210>  66
<211>  642
<212>  PRT
<213>  Mus musculus

<400>  66

Met Trp Arg Val Cys Ala Arg Arg Ala Arg Ser Ala Val Pro Arg Asp 
1               5                   10                  15      


Gly Phe Arg Ala Arg Trp Ala Ala Leu Lys Glu Gly Pro Gly Ala Pro 
            20                  25                  30          


Cys Gly Ser Pro Arg Ile Gly Pro Ala Ala Val Arg Cys Gly Ser Gly 
        35                  40                  45              


Ile Pro Arg Tyr Gly Val Arg Ser Leu Cys Gly Trp Ser Ser Gly Ser 
    50                  55                  60                  


Gly Thr Val Pro Arg Asn Arg Leu Leu Arg Gln Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Ser Arg Arg Ser Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro 
                85                  90                  95      


Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys 
            100                 105                 110         


Lys Glu Gly Glu Lys Ile Ser Glu Gly Asp Leu Ile Ala Glu Val Glu 
        115                 120                 125             


Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met 
    130                 135                 140                 


Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Val Gly Ser 
145                 150                 155                 160 


Ile Ile Cys Ile Thr Val Glu Lys Pro Gln Asp Ile Glu Ala Phe Lys 
                165                 170                 175     


Asn Tyr Thr Leu Asp Leu Ala Ala Ala Ala Ala Pro Gln Ala Ala Pro 
            180                 185                 190         


Ala Ala Ala Pro Ala Pro Ala Ala Ala Pro Ala Ala Pro Ser Ala Ser 
        195                 200                 205             


Ala Pro Gly Ser Ser Tyr Pro Thr His Met Gln Ile Val Leu Pro Ala 
    210                 215                 220                 


Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys Lys 
225                 230                 235                 240 


Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr 
                245                 250                 255     


Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala 
            260                 265                 270         


Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Ala Pro 
        275                 280                 285             


Leu Cys Ile Ile Val Glu Lys Gln Glu Asp Ile Ala Ala Phe Ala Asp 
    290                 295                 300                 


Tyr Arg Pro Thr Glu Val Thr Ser Leu Lys Pro Gln Ala Ala Pro Pro 
305                 310                 315                 320 


Ala Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Val Ala 
                325                 330                 335     


Pro Thr Pro Ser Ala Ala Pro Ala Gly Pro Lys Gly Arg Val Phe Val 
            340                 345                 350         


Ser Pro Leu Ala Lys Lys Leu Ala Ala Glu Lys Gly Ile Asp Leu Thr 
        355                 360                 365             


Gln Val Lys Gly Thr Gly Pro Glu Gly Arg Ile Ile Lys Lys Asp Ile 
    370                 375                 380                 


Asp Ser Phe Val Pro Ser Lys Ala Ala Pro Ala Ala Ala Ala Ala Met 
385                 390                 395                 400 


Ala Pro Pro Gly Pro Arg Val Ala Pro Ala Pro Ala Gly Val Phe Thr 
                405                 410                 415     


Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile Ala Gln Arg Leu Met 
            420                 425                 430         


Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu Ser Val Asp Val Asn 
        435                 440                 445             


Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu Asn Lys Met Leu Glu 
    450                 455                 460                 


Gly Lys Gly Lys Ile Ser Val Asn Asp Phe Ile Ile Lys Ala Ser Ala 
465                 470                 475                 480 


Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser Ser Trp Met Asp Thr 
                485                 490                 495     


Val Ile Arg Gln Asn His Val Val Asp Val Ser Val Ala Val Ser Thr 
            500                 505                 510         


Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn Ala His Ile Lys Gly 
        515                 520                 525             


Leu Glu Thr Ile Ala Ser Asp Val Val Ser Leu Ala Ser Lys Ala Arg 
    530                 535                 540                 


Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly Gly Thr Phe Thr Ile 
545                 550                 555                 560 


Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe Ser Ala Ile Ile Asn 
                565                 570                 575     


Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala Ser Glu Asp Lys Leu 
            580                 585                 590         


Ile Pro Ala Asp Asn Glu Lys Gly Phe Asp Val Ala Ser Val Met Ser 
        595                 600                 605             


Val Thr Leu Ser Cys Asp His Arg Val Val Asp Gly Ala Val Gly Ala 
    610                 615                 620                 


Gln Trp Leu Ala Glu Phe Lys Lys Tyr Leu Glu Lys Pro Ile Thr Met 
625                 630                 635                 640 


Leu Leu 
        


<210>  67
<211>  727
<212>  PRT
<213>  Mus musculus

<400>  67

Met Leu Arg Ile Pro Ile Lys Arg Ala Leu Ile Gly Leu Ser Asn Ser 
1               5                   10                  15      


Pro Lys Gly Tyr Val Arg Thr Thr Gly Thr Ala Ala Ser Asn Leu Ile 
            20                  25                  30          


Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr 
        35                  40                  45              


Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys 
    50                  55                  60                  


Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val 
65                  70                  75                  80  


Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val 
                85                  90                  95      


Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala 
            100                 105                 110         


Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys 
        115                 120                 125             


Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met 
    130                 135                 140                 


Met Phe Gly Ser Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val 
145                 150                 155                 160 


Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys 
                165                 170                 175     


Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val 
            180                 185                 190         


Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr 
        195                 200                 205             


Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Val Ile Asp 
    210                 215                 220                 


Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala 
225                 230                 235                 240 


Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala 
                245                 250                 255     


Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg 
            260                 265                 270         


Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp 
        275                 280                 285             


Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu 
    290                 295                 300                 


Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu 
305                 310                 315                 320 


Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Asn Phe Glu Gly Asn 
                325                 330                 335     


Ala Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val 
            340                 345                 350         


Ala Leu Lys Asp Leu Leu Asn Lys Val Asp Ser Asp Asn Leu Cys Thr 
        355                 360                 365             


Glu Glu Ile Phe Pro Thr Glu Gly Ala Gly Thr Asp Leu Arg Ser Asn 
    370                 375                 380                 


Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val 
385                 390                 395                 400 


Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala 
                405                 410                 415     


Arg Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile 
            420                 425                 430         


Gly Ser Pro Val Asp Leu Thr Tyr Arg Tyr Asp His Leu Gly Asp Ser 
        435                 440                 445             


Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Arg His Ser Phe Cys Glu 
    450                 455                 460                 


Val Leu Lys Asp Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala 
465                 470                 475                 480 


Leu Gln Arg Asp Asp Gly Ala Ala Ile Leu Val Ala Val Ser Asn Met 
                485                 490                 495     


Val Gln Lys Ile Arg Val Thr Thr Gly Val Ala Ala Glu Trp Lys Val 
            500                 505                 510         


Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu 
        515                 520                 525             


Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Met 
    530                 535                 540                 


Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu 
545                 550                 555                 560 


Pro Lys Asp Cys Phe Ile Val Tyr Gln Gly His His Gly Asp Val Gly 
                565                 570                 575     


Ala Pro Met Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys 
            580                 585                 590         


Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val 
        595                 600                 605             


Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg 
    610                 615                 620                 


Ala Leu Ser Glu Ile Ala Gly Ile Thr Leu Pro Tyr Asp Thr Leu Asp 
625                 630                 635                 640 


Gln Val Arg Asn Arg Leu Glu Glu Val Ser Pro Asn Leu Val Arg Tyr 
                645                 650                 655     


Asp Asp Ile Glu Glu Thr Asn Tyr Phe Gln Gln Ala Ser Glu Leu Ala 
            660                 665                 670         


Lys Leu Val Asn Gln Glu Val Leu Ala Asp Pro Leu Val Pro Pro Gln 
        675                 680                 685             


Leu Thr Ile Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser 
    690                 695                 700                 


Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala 
705                 710                 715                 720 


Val Glu Glu Pro Ser Ile Cys 
                725         


<210>  68
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  69
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Pro His Ser Tyr Pro Ala Leu Ser Ala Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala Leu Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Val Gly Ser Met Ala Lys Arg Leu Ser Gln Ile Gly 
        35                  40                  45              


Val Glu Asn Thr Glu Glu Asn Arg Arg Leu Tyr Arg Gln Val Leu Phe 
    50                  55                  60                  


Ser Ala Asp Asp Arg Val Lys Lys Cys Ile Gly Gly Val Ile Phe Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Asp Asp Asn Gly Val Pro Phe Val Arg 
                85                  90                  95      


Thr Ile Gln Asp Lys Gly Ile Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asp Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Ser Glu Arg Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Leu Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Pro Ile Lys Tyr Thr Pro Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Pro Gly Val Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Phe Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Arg Cys Pro Leu Pro Arg Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Asn Ala Trp Arg Gly Gln Arg Asp Asn 
305                 310                 315                 320 


Ala Gly Ala Ala Thr Glu Glu Phe Ile Lys Arg Ala Glu Val Asn Gly 
                325                 330                 335     


Leu Ala Ala Gln Gly Lys Tyr Glu Gly Ser Gly Glu Asp Gly Gly Ala 
            340                 345                 350         


Ala Ala Gln Ser Leu Tyr Ile Ala Asn His Ala Tyr 
        355                 360                 


<210>  70
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210>  71
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  72
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ser Lys Arg Asp Ile Val Leu Thr Asn Val Thr Val Val Gln Leu 
1               5                   10                  15      


Leu Arg Gln Pro Cys Pro Val Thr Arg Ala Pro Pro Pro Pro Glu Pro 
            20                  25                  30          


Lys Ala Glu Val Glu Pro Gln Pro Gln Pro Glu Pro Thr Pro Val Arg 
        35                  40                  45              


Glu Glu Ile Lys Pro Pro Pro Pro Pro Leu Pro Pro His Pro Ala Thr 
    50                  55                  60                  


Pro Pro Pro Lys Met Val Ser Val Ala Arg Glu Leu Thr Val Gly Ile 
65                  70                  75                  80  


Asn Gly Phe Gly Arg Ile Gly Arg Leu Val Leu Arg Ala Cys Met Glu 
                85                  90                  95      


Lys Gly Val Lys Val Val Ala Val Asn Asp Pro Phe Ile Asp Pro Glu 
            100                 105                 110         


Tyr Met Val Tyr Met Phe Lys Tyr Asp Ser Thr His Gly Arg Tyr Lys 
        115                 120                 125             


Gly Ser Val Glu Phe Arg Asn Gly Gln Leu Val Val Asp Asn His Glu 
    130                 135                 140                 


Ile Ser Val Tyr Gln Cys Lys Glu Pro Lys Gln Ile Pro Trp Arg Ala 
145                 150                 155                 160 


Val Gly Ser Pro Tyr Val Val Glu Ser Thr Gly Val Tyr Leu Ser Ile 
                165                 170                 175     


Gln Ala Ala Ser Asp His Ile Ser Ala Gly Ala Gln Arg Val Val Ile 
            180                 185                 190         


Ser Ala Pro Ser Pro Asp Ala Pro Met Phe Val Met Gly Val Asn Glu 
        195                 200                 205             


Asn Asp Tyr Asn Pro Gly Ser Met Asn Ile Val Ser Asn Ala Ser Cys 
    210                 215                 220                 


Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Glu Arg Phe 
225                 230                 235                 240 


Gly Ile Val Glu Gly Leu Met Thr Thr Val His Ser Tyr Thr Ala Thr 
                245                 250                 255     


Gln Lys Thr Val Asp Gly Pro Ser Arg Lys Ala Trp Arg Asp Gly Arg 
            260                 265                 270         


Gly Ala His Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala 
        275                 280                 285             


Val Thr Lys Val Ile Pro Glu Leu Lys Gly Lys Leu Thr Gly Met Ala 
    290                 295                 300                 


Phe Arg Val Pro Thr Pro Asp Val Ser Val Val Asp Leu Thr Cys Arg 
305                 310                 315                 320 


Leu Ala Gln Pro Ala Pro Tyr Ser Ala Ile Lys Glu Ala Val Lys Ala 
                325                 330                 335     


Ala Ala Lys Gly Pro Met Ala Gly Ile Leu Ala Tyr Thr Glu Asp Glu 
            340                 345                 350         


Val Val Ser Thr Asp Phe Leu Gly Asp Thr His Ser Ser Ile Phe Asp 
        355                 360                 365             


Ala Lys Ala Gly Ile Ala Leu Asn Asp Asn Phe Val Lys Leu Ile Ser 
    370                 375                 380                 


Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser His Arg Val Val Asp Leu Leu 
385                 390                 395                 400 


Arg Tyr Met Phe Ser Arg Asp Lys 
                405             


<210>  73
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  74
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  75
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  76
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  77
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  78
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  79
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  80
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Trp Arg Val Cys Ala Arg Arg Ala Gln Asn Val Ala Pro Trp Ala 
1               5                   10                  15      


Gly Leu Glu Ala Arg Trp Thr Ala Leu Gln Glu Val Pro Gly Thr Pro 
            20                  25                  30          


Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val 
        35                  40                  45              


Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser 
    50                  55                  60                  


Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser 
65                  70                  75                  80  


Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu 
                85                  90                  95      


Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu 
            100                 105                 110         


Lys Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val 
        115                 120                 125             


Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr 
    130                 135                 140                 


Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly 
145                 150                 155                 160 


Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe 
                165                 170                 175     


Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala 
            180                 185                 190         


Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala 
        195                 200                 205             


Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro 
    210                 215                 220                 


Ala Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys 
225                 230                 235                 240 


Lys Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu 
                245                 250                 255     


Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu 
            260                 265                 270         


Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr 
        275                 280                 285             


Pro Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala 
    290                 295                 300                 


Asp Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Val Pro Pro 
305                 310                 315                 320 


Pro Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu 
                325                 330                 335     


Ala Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys 
            340                 345                 350         


Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu Lys 
        355                 360                 365             


Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile 
    370                 375                 380                 


Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala 
385                 390                 395                 400 


Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro 
                405                 410                 415     


Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile 
            420                 425                 430         


Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu 
        435                 440                 445             


Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu 
    450                 455                 460                 


Asn Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile 
465                 470                 475                 480 


Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser 
                485                 490                 495     


Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser 
            500                 505                 510         


Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn 
        515                 520                 525             


Ala His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu 
    530                 535                 540                 


Ala Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly 
545                 550                 555                 560 


Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe 
                565                 570                 575     


Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala 
            580                 585                 590         


Ser Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val 
        595                 600                 605             


Ala Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp 
    610                 615                 620                 


Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu 
625                 630                 635                 640 


Lys Pro Ile Thr Met Leu Leu 
                645         


<210>  81
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Gly Pro Ala Trp Ile Ser Lys Val Ser Arg Leu Leu Gly Ala 
1               5                   10                  15      


Phe His Asn Pro Lys Gln Val Thr Arg Gly Phe Thr Gly Gly Val Gln 
            20                  25                  30          


Thr Val Thr Leu Ile Pro Gly Asp Gly Ile Gly Pro Glu Ile Ser Ala 
        35                  40                  45              


Ala Val Met Lys Ile Phe Asp Ala Ala Lys Ala Pro Ile Gln Trp Glu 
    50                  55                  60                  


Glu Arg Asn Val Thr Ala Ile Gln Gly Pro Gly Gly Lys Trp Met Ile 
65                  70                  75                  80  


Pro Ser Glu Ala Lys Glu Ser Met Asp Lys Asn Lys Met Gly Leu Lys 
                85                  90                  95      


Gly Pro Leu Lys Thr Pro Ile Ala Ala Gly His Pro Ser Met Asn Leu 
            100                 105                 110         


Leu Leu Arg Lys Thr Phe Asp Leu Tyr Ala Asn Val Arg Pro Cys Val 
        115                 120                 125             


Ser Ile Glu Gly Tyr Lys Thr Pro Tyr Thr Asp Val Asn Ile Val Thr 
    130                 135                 140                 


Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile Glu His Val Ile 
145                 150                 155                 160 


Val Asp Gly Val Val Gln Ser Ile Lys Leu Ile Thr Glu Gly Ala Ser 
                165                 170                 175     


Lys Arg Ile Ala Glu Phe Ala Phe Glu Tyr Ala Arg Asn Asn His Arg 
            180                 185                 190         


Ser Asn Val Thr Ala Val His Lys Ala Asn Ile Met Arg Met Ser Asp 
        195                 200                 205             


Gly Leu Phe Leu Gln Lys Cys Arg Glu Val Ala Glu Ser Cys Lys Asp 
    210                 215                 220                 


Ile Lys Phe Asn Glu Met Tyr Leu Asp Thr Val Cys Leu Asn Met Val 
225                 230                 235                 240 


Gln Asp Pro Ser Gln Phe Asp Val Leu Val Met Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Leu Cys Ala Gly Leu Ile Gly Gly Leu Gly Val 
            260                 265                 270         


Thr Pro Ser Gly Asn Ile Gly Ala Asn Gly Val Ala Ile Phe Glu Ser 
        275                 280                 285             


Val His Gly Thr Ala Pro Asp Ile Ala Gly Lys Asp Met Ala Asn Pro 
    290                 295                 300                 


Thr Ala Leu Leu Leu Ser Ala Val Met Met Leu Arg His Met Gly Leu 
305                 310                 315                 320 


Phe Asp His Ala Ala Arg Ile Glu Ala Ala Cys Phe Ala Thr Ile Lys 
                325                 330                 335     


Asp Gly Lys Ser Leu Thr Lys Asp Leu Gly Gly Asn Ala Lys Cys Ser 
            340                 345                 350         


Asp Phe Thr Glu Glu Ile Cys Arg Arg Val Lys Asp Leu Asp 
        355                 360                 365     


<210>  82
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile 
1               5                   10                  15      


Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys 
            20                  25                  30          


Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly 
        35                  40                  45              


Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu 
    50                  55                  60                  


Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp 
65                  70                  75                  80  


Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met 
                85                  90                  95      


Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln 
            100                 105                 110         


Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val 
        115                 120                 125             


Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala 
    130                 135                 140                 


Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His 
145                 150                 155                 160 


Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn 
                165                 170                 175     


Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr 
            180                 185                 190         


Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly 
        195                 200                 205             


Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Val 
    210                 215                 220                 


Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu 
225                 230                 235                 240 


Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp 
                245                 250                 255     


Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile 
            260                 265                 270         


Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe 
        275                 280                 285             


Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro 
    290                 295                 300                 


Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu 
305                 310                 315                 320 


Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala 
                325                 330                 


<210>  83
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Pro Gly Ile Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Asp 
1               5                   10                  15      


Glu Val Lys Ile Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr 
            20                  25                  30          


Gly Ala Gln Cys Asp Lys Pro Asn Lys Glu Phe Met Leu Cys Arg Trp 
        35                  40                  45              


Glu Glu Lys Asp Pro Arg Arg Cys Leu Glu Glu Gly Lys Leu Val Asn 
    50                  55                  60                  


Lys Cys Ala Leu Asp Phe Phe Arg Gln Ile Lys Arg His Cys Ala Glu 
65                  70                  75                  80  


Pro Phe Thr Glu Tyr Trp Thr Cys Ile Asp Tyr Thr Gly Gln Gln Leu 
                85                  90                  95      


Phe Arg His Cys Arg Lys Gln Gln Ala Lys Phe Asp Glu Cys Val Leu 
            100                 105                 110         


Asp Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Glu Leu Ser Lys Val 
        115                 120                 125             


Thr Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser 
    130                 135                 140                 


Arg Pro Arg Pro Asp Pro Ser Pro Glu Ile Glu Gly Asp Leu Gln Pro 
145                 150                 155                 160 


Ala Thr His Gly Ser Arg Phe Tyr Phe Trp Thr Lys 
                165                 170         


<210>  84
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Leu Arg Ile Pro Val Arg Lys Ala Leu Val Gly Leu Ser Lys Ser 
1               5                   10                  15      


Pro Lys Gly Cys Val Arg Thr Thr Ala Thr Ala Ala Ser Asn Leu Ile 
            20                  25                  30          


Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr 
        35                  40                  45              


Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys 
    50                  55                  60                  


Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val 
65                  70                  75                  80  


Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val 
                85                  90                  95      


Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala 
            100                 105                 110         


Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys 
        115                 120                 125             


Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met 
    130                 135                 140                 


Met Phe Gly Asn Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val 
145                 150                 155                 160 


Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys 
                165                 170                 175     


Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val 
            180                 185                 190         


Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr 
        195                 200                 205             


Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Ile Ile Asp 
    210                 215                 220                 


Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala 
225                 230                 235                 240 


Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala 
                245                 250                 255     


Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg 
            260                 265                 270         


Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp 
        275                 280                 285             


Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu 
    290                 295                 300                 


Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu 
305                 310                 315                 320 


Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Ser Phe Gln Gly Lys 
                325                 330                 335     


Asp Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val 
            340                 345                 350         


Ala Leu Lys Asp Leu Leu Asn Arg Val Asp Ser Asp Thr Leu Cys Thr 
        355                 360                 365             


Glu Glu Val Phe Pro Thr Ala Gly Ala Gly Thr Asp Leu Arg Ser Asn 
    370                 375                 380                 


Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val 
385                 390                 395                 400 


Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala 
                405                 410                 415     


Arg Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile 
            420                 425                 430         


Gly Ser Pro Val Asp Leu Thr Tyr Thr Tyr Asp His Leu Gly Asp Ser 
        435                 440                 445             


Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Ser His Pro Phe Ser Gln 
    450                 455                 460                 


Val Leu Lys Glu Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala 
465                 470                 475                 480 


Leu Gln Arg Asn Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Ser Ile 
                485                 490                 495     


Ala Gln Lys Ile Arg Met Thr Ser Gly Val Thr Gly Asp Trp Lys Val 
            500                 505                 510         


Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu 
        515                 520                 525             


Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Val 
    530                 535                 540                 


Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu 
545                 550                 555                 560 


Pro Lys Asp Cys Phe Ile Ile Tyr Gln Gly His His Gly Asp Val Gly 
                565                 570                 575     


Ala Pro Ile Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys 
            580                 585                 590         


Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val 
        595                 600                 605             


Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg 
    610                 615                 620                 


Ala Leu Ser Glu Ile Ala Gly Met Thr Leu Pro Tyr Asp Thr Leu Asp 
625                 630                 635                 640 


Gln Val Arg Asn Arg Leu Glu Glu Val Ser Pro Asn Leu Val Arg Tyr 
                645                 650                 655     


Asp Asp Ile Glu Gly Ala Asn Tyr Phe Gln Gln Ala Asn Glu Leu Ser 
            660                 665                 670         


Lys Leu Val Asn Gln Gln Leu Leu Ala Asp Pro Leu Val Pro Pro Gln 
        675                 680                 685             


Leu Thr Ile Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser 
    690                 695                 700                 


Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala 
705                 710                 715                 720 


Val Glu Glu Pro Ser Ile Cys 
                725         


<210>  85
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
        35                  40                  45              


Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
    50                  55                  60                  


Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
65                  70                  75                  80  


Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                85                  90                  95      


Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
            100                 105                 110         


Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile 
        115                 120                 125             


Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp 
    130                 135                 140                 


Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys 
145                 150                 155                 160 


Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu 
                165                 170                 175     


Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly 
            180                 185                 190         


Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu 
        195                 200                 205             


Tyr Arg 
    210 


<210>  86
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Ala Ser Val Val Cys Arg Ala Ala Thr Ala Gly Ala Gln Val 
1               5                   10                  15      


Leu Leu Arg Ala Arg Arg Ser Pro Ala Leu Leu Arg Thr Pro Ala Leu 
            20                  25                  30          


Arg Ser Thr Ala Thr Phe Ala Gln Ala Leu Gln Phe Val Pro Glu Thr 
        35                  40                  45              


Gln Val Ser Leu Leu Asp Asn Gly Leu Arg Val Ala Ser Glu Gln Ser 
    50                  55                  60                  


Ser Gln Pro Thr Cys Thr Val Gly Val Trp Ile Asp Val Gly Ser Arg 
65                  70                  75                  80  


Phe Glu Thr Glu Lys Asn Asn Gly Ala Gly Tyr Phe Leu Glu His Leu 
                85                  90                  95      


Ala Phe Lys Gly Thr Lys Asn Arg Pro Gly Ser Ala Leu Glu Lys Glu 
            100                 105                 110         


Val Glu Ser Met Gly Ala His Leu Asn Ala Tyr Ser Thr Arg Glu His 
        115                 120                 125             


Thr Ala Tyr Tyr Ile Lys Ala Leu Ser Lys Asp Leu Pro Lys Ala Val 
    130                 135                 140                 


Glu Leu Leu Gly Asp Ile Val Gln Asn Cys Ser Leu Glu Asp Ser Gln 
145                 150                 155                 160 


Ile Glu Lys Glu Arg Asp Val Ile Leu Arg Glu Met Gln Glu Asn Asp 
                165                 170                 175     


Ala Ser Met Arg Asp Val Val Phe Asn Tyr Leu His Ala Thr Ala Phe 
            180                 185                 190         


Gln Gly Thr Pro Leu Ala Gln Ala Val Glu Gly Pro Ser Glu Asn Val 
        195                 200                 205             


Arg Lys Leu Ser Arg Ala Asp Leu Thr Glu Tyr Leu Ser Thr His Tyr 
    210                 215                 220                 


Lys Ala Pro Arg Met Val Leu Ala Ala Ala Gly Gly Val Glu His Gln 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Ala Gln Lys His Leu Gly Gly Ile Pro Trp Thr 
                245                 250                 255     


Tyr Ala Glu Asp Ala Val Pro Thr Leu Thr Pro Cys Arg Phe Thr Gly 
            260                 265                 270         


Ser Glu Ile Arg His Arg Asp Asp Ala Leu Pro Phe Ala His Val Ala 
        275                 280                 285             


Ile Ala Val Glu Gly Pro Gly Trp Ala Ser Pro Asp Asn Val Ala Leu 
    290                 295                 300                 


Gln Val Ala Asn Ala Ile Ile Gly His Tyr Asp Cys Thr Tyr Gly Gly 
305                 310                 315                 320 


Gly Val His Leu Ser Ser Pro Leu Ala Ser Gly Ala Val Ala Asn Lys 
                325                 330                 335     


Leu Cys Gln Ser Phe Gln Thr Phe Ser Ile Cys Tyr Ala Glu Thr Gly 
            340                 345                 350         


Leu Leu Gly Ala His Phe Val Cys Asp Arg Met Lys Ile Asp Asp Met 
        355                 360                 365             


Met Phe Val Leu Gln Gly Gln Trp Met Arg Leu Cys Thr Ser Ala Thr 
    370                 375                 380                 


Glu Ser Glu Val Ala Arg Gly Lys Asn Ile Leu Arg Asn Ala Leu Val 
385                 390                 395                 400 


Ser His Leu Asp Gly Thr Thr Pro Val Cys Glu Asp Ile Gly Arg Ser 
                405                 410                 415     


Leu Leu Thr Tyr Gly Arg Arg Ile Pro Leu Ala Glu Trp Glu Ser Arg 
            420                 425                 430         


Ile Ala Glu Val Asp Ala Ser Val Val Arg Glu Ile Cys Ser Lys Tyr 
        435                 440                 445             


Ile Tyr Asp Gln Cys Pro Ala Val Ala Gly Tyr Gly Pro Ile Glu Gln 
    450                 455                 460                 


Leu Pro Asp Tyr Asn Arg Ile Arg Ser Gly Met Phe Trp Leu Arg Phe 
465                 470                 475                 480 


<210>  87
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Phe Asn Ala Leu Lys Val Pro 
65                  70                  75                  80  


Val Pro Glu Asp Lys Tyr Thr Ala Gln Val Asp Ala Glu Glu Lys Glu 
                85                  90                  95      


Asp Val Lys Ser Cys Ala Glu Trp Val Ser Leu Ser Lys Ala Arg Ile 
            100                 105                 110         


Val Glu Tyr Glu Lys Glu Met Glu Lys Met Lys Asn Leu Ile Pro Phe 
        115                 120                 125             


Asp Gln Met Thr Ile Glu Asp Leu Asn Glu Ala Phe Pro Glu Thr Lys 
    130                 135                 140                 


Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn 
145                 150                 155                 160 


Leu 
    


<210>  88
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Val Lys Ser Cys Ala Glu Trp 
65                  70                  75                  80  


Val Ser Leu Ser Lys Ala Arg Ile Val Glu Tyr Glu Lys Glu Met Glu 
                85                  90                  95      


Lys Met Lys Asn Leu Ile Pro Phe Asp Gln Met Thr Ile Glu Asp Leu 
            100                 105                 110         


Asn Glu Ala Phe Pro Glu Thr Lys Leu Asp Lys Lys Lys Tyr Pro Tyr 
        115                 120                 125             


Trp Pro His Gln Pro Ile Glu Asn Leu 
    130                 135         


<210>  89
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      


Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         


Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 


Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     


Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met 
            260                 265                 270         


Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys 
    290                 295                 300                 


His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             


Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     


<210>  90
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  91
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Met 
    450                 455                 460                 


Pro Gly Gly Met Pro Gly Gly Phe Pro Gly Gly Gly Ala Pro Pro Ser 
465                 470                 475                 480 


Gly Gly Ala Ser Ser Gly Pro Thr Ile Glu Glu Val Asp 
                485                 490             


<210>  92
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  93
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  94
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Thr Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Thr Ala Cys 
            20                  25                  30          


Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser 
        35                  40                  45              


Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile 
    50                  55                  60                  


Gln Val Tyr Glu Glu Thr Ser Gly Val Ser Val Gly Asp Pro Val Leu 
65                  70                  75                  80  


Arg Thr Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly 
                85                  90                  95      


Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln 
            100                 105                 110         


Thr Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser 
        115                 120                 125             


Arg Asp Ile Lys Trp Asp Phe Thr Pro Cys Lys Asn Leu Arg Val Gly 
    130                 135                 140                 


Ser His Ile Thr Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Thr Val 
                165                 170                 175     


Thr Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Thr Ser Asp Val Val Leu 
            180                 185                 190         


Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Thr Met Val Gln Val 
        195                 200                 205             


Trp Pro Val Arg Gln Val Arg Pro Val Thr Glu Lys Leu Pro Ala Asn 
    210                 215                 220                 


His Pro Leu Leu Thr Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys 
225                 230                 235                 240 


Val Gln Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys 
                245                 250                 255     


Thr Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile 
            260                 265                 270         


Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu 
        275                 280                 285             


Arg Asp Phe Pro Glu Leu Thr Met Glu Val Asp Gly Lys Val Glu Ser 
    290                 295                 300                 


Ile Met Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val 
305                 310                 315                 320 


Ala Ala Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr 
                325                 330                 335     


Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Thr Ser 
            340                 345                 350         


Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met 
        355                 360                 365             


Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser 
    370                 375                 380                 


Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg 
385                 390                 395                 400 


Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp 
                405                 410                 415     


Phe Ser Asp Pro Val Thr Ser Ala Thr Leu Gly Ile Val Gln Val Phe 
            420                 425                 430         


Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val 
        435                 440                 445             


Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr 
    450                 455                 460                 


Tyr Asp Lys His Phe Thr Glu Phe Val Pro Leu Arg Thr Lys Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Gln Glu Glu Glu Asp Leu Ala Glu Ile Val Gln Leu Val 
                485                 490                 495     


Gly Lys Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala 
            500                 505                 510         


Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Thr Pro Tyr 
        515                 520                 525             


Asp Arg Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Ser Asn Met 
    530                 535                 540                 


Ile Ala Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Thr Thr Ala Gln 
545                 550                 555                 560 


Ser Asp Asn Lys Ile Thr Trp Ser Ile Ile Arg Glu His Met Gly Asp 
                565                 570                 575     


Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Leu Lys Asp 
            580                 585                 590         


Gly Glu Ala Lys Ile Lys Ser Asp Tyr Ala Gln Leu Leu Glu Asp Met 
        595                 600                 605             


Gln Asn Ala Phe Arg Ser Leu Glu Asp 
    610                 615         


<210>  95
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Glu Glu Ile Gly Ile Leu Val Glu Lys Ala Gln Asp Glu Ile Pro 
1               5                   10                  15      


Ala Leu Ser Val Ser Arg Pro Gln Thr Gly Leu Ser Phe Leu Gly Pro 
            20                  25                  30          


Glu Pro Glu Asp Leu Glu Asp Leu Tyr Ser Arg Tyr Lys Lys Leu Gln 
        35                  40                  45              


Gln Glu Leu Glu Phe Leu Glu Val Gln Glu Glu Tyr Ile Lys Asp Glu 
    50                  55                  60                  


Gln Lys Asn Leu Lys Lys Glu Phe Leu His Ala Gln Glu Glu Val Lys 
65                  70                  75                  80  


Arg Ile Gln Ser Ile Pro Leu Val Ile Gly Gln Phe Leu Glu Ala Val 
                85                  90                  95      


Asp Gln Asn Thr Ala Ile Val Gly Ser Thr Thr Gly Ser Asn Tyr Tyr 
            100                 105                 110         


Val Arg Ile Leu Ser Thr Ile Asp Arg Glu Leu Leu Lys Pro Asn Ala 
        115                 120                 125             


Ser Val Ala Leu His Lys His Ser Asn Ala Leu Val Asp Val Leu Pro 
    130                 135                 140                 


Pro Glu Ala Asp Ser Ser Ile Met Met Leu Thr Ser Asp Gln Lys Pro 
145                 150                 155                 160 


Asp Val Met Tyr Ala Asp Ile Gly Gly Met Asp Ile Gln Lys Gln Glu 
                165                 170                 175     


Val Arg Glu Ala Val Glu Leu Pro Leu Thr His Phe Glu Leu Tyr Lys 
            180                 185                 190         


Gln Ile Gly Ile Asp Pro Pro Arg Gly Val Leu Met Tyr Gly Pro Pro 
        195                 200                 205             


Gly Cys Gly Lys Thr Met Leu Ala Lys Ala Val Ala His His Thr Thr 
    210                 215                 220                 


Ala Ala Phe Ile Arg Val Val Gly Ser Glu Phe Val Gln Lys Tyr Leu 
225                 230                 235                 240 


Gly Glu Gly Pro Arg Met Val Arg Asp Val Phe Arg Leu Ala Lys Glu 
                245                 250                 255     


Asn Ala Pro Ala Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Ala Thr 
            260                 265                 270         


Lys Arg Phe Asp Ala Gln Thr Gly Ala Asp Arg Glu Val Gln Arg Ile 
        275                 280                 285             


Leu Leu Glu Leu Leu Asn Gln Met Asp Gly Phe Asp Gln Asn Val Asn 
    290                 295                 300                 


Val Lys Val Ile Met Ala Thr Asn Arg Ala Asp Thr Leu Asp Pro Ala 
305                 310                 315                 320 


Leu Leu Arg Pro Gly Arg Leu Asp Arg Lys Ile Glu Phe Pro Leu Pro 
                325                 330                 335     


Asp Arg Arg Gln Lys Arg Leu Ile Phe Ser Thr Ile Thr Ser Lys Met 
            340                 345                 350         


Asn Leu Ser Glu Glu Val Asp Leu Glu Asp Tyr Val Ala Arg Pro Asp 
        355                 360                 365             


Lys Ile Ser Gly Ala Asp Ile Asn Ser Ile Cys Gln Glu Ser Gly Met 
    370                 375                 380                 


Leu Ala Val Arg Glu Asn Arg Tyr Ile Val Leu Ala Lys Asp Phe Glu 
385                 390                 395                 400 


Lys Ala Tyr Lys Thr Val Ile Lys Lys Asp Glu Gln Glu His Glu Phe 
                405                 410                 415     


Tyr Lys 
        


<210>  96
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Glu Glu Ile Gly Ile Leu Val Glu Lys Ala Gln Asp Glu Ile Pro 
1               5                   10                  15      


Ala Leu Ser Val Ser Arg Pro Gln Thr Gly Leu Ser Phe Leu Gly Pro 
            20                  25                  30          


Glu Pro Glu Asp Leu Glu Asp Leu Tyr Ser Arg Tyr Lys Glu Glu Val 
        35                  40                  45              


Lys Arg Ile Gln Ser Ile Pro Leu Val Ile Gly Gln Phe Leu Glu Ala 
    50                  55                  60                  


Val Asp Gln Asn Thr Ala Ile Val Gly Ser Thr Thr Gly Ser Asn Tyr 
65                  70                  75                  80  


Tyr Val Arg Ile Leu Ser Thr Ile Asp Arg Glu Leu Leu Lys Pro Asn 
                85                  90                  95      


Ala Ser Val Ala Leu His Lys His Ser Asn Ala Leu Val Asp Val Leu 
            100                 105                 110         


Pro Pro Glu Ala Asp Ser Ser Ile Met Met Leu Thr Ser Asp Gln Lys 
        115                 120                 125             


Pro Asp Val Met Tyr Ala Asp Ile Gly Gly Met Asp Ile Gln Lys Gln 
    130                 135                 140                 


Glu Val Arg Glu Ala Val Glu Leu Pro Leu Thr His Phe Glu Leu Tyr 
145                 150                 155                 160 


Lys Gln Ile Gly Ile Asp Pro Pro Arg Gly Val Leu Met Tyr Gly Pro 
                165                 170                 175     


Pro Gly Cys Gly Lys Thr Met Leu Ala Lys Ala Val Ala His His Thr 
            180                 185                 190         


Thr Ala Ala Phe Ile Arg Val Val Gly Ser Glu Phe Val Gln Lys Tyr 
        195                 200                 205             


Leu Gly Glu Gly Pro Arg Met Val Arg Asp Val Phe Arg Leu Ala Lys 
    210                 215                 220                 


Glu Asn Ala Pro Ala Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Ala 
225                 230                 235                 240 


Thr Lys Arg Phe Asp Ala Gln Thr Gly Ala Asp Arg Glu Val Gln Arg 
                245                 250                 255     


Ile Leu Leu Glu Leu Leu Asn Gln Met Asp Gly Phe Asp Gln Asn Val 
            260                 265                 270         


Asn Val Lys Val Ile Met Ala Thr Asn Arg Ala Asp Thr Leu Asp Pro 
        275                 280                 285             


Ala Leu Leu Arg Pro Gly Arg Leu Asp Arg Lys Ile Glu Phe Pro Leu 
    290                 295                 300                 


Pro Asp Arg Arg Gln Lys Arg Leu Ile Phe Ser Thr Ile Thr Ser Lys 
305                 310                 315                 320 


Met Asn Leu Ser Glu Glu Val Asp Leu Glu Asp Tyr Val Ala Arg Pro 
                325                 330                 335     


Asp Lys Ile Ser Gly Ala Asp Ile Asn Ser Ile Cys Gln Glu Ser Gly 
            340                 345                 350         


Met Leu Ala Val Arg Glu Asn Arg Tyr Ile Val Leu Ala Lys Asp Phe 
        355                 360                 365             


Glu Lys Ala Tyr Lys Thr Val Ile Lys Lys Asp Glu Gln Glu His Glu 
    370                 375                 380                 


Phe Tyr Lys 
385         


<210>  97
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser 
1               5                   10                  15      


Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly 
            20                  25                  30          


Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr 
        35                  40                  45              


Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys 
    50                  55                  60                  


Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly 
65                  70                  75                  80  


Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln 
                85                  90                  95      


Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln 
            100                 105                 110         


Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg 
        115                 120                 125             


Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro 
    130                 135                 140                 


Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala 
145                 150                 155                 160 


Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys 
                165                 170                 175     


Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile 
            180                 185                 190         


Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile 
        195                 200                 205             


Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr 
    210                 215                 220                 


Glu Val Lys Asp Tyr Leu Ala Ala Ile Ala 
225                 230                 


<210>  98
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn Lys Val 
1               5                   10                  15      


Leu Ser Arg Leu Gly Val Ala Gly Gln Trp Arg Phe Val Asp Val Leu 
            20                  25                  30          


Gly Leu Glu Glu Glu Ser Leu Gly Ser Val Pro Ala Pro Ala Cys Ala 
        35                  40                  45              


Leu Leu Leu Leu Phe Pro Leu Thr Ala Gln His Glu Asn Phe Arg Lys 
    50                  55                  60                  


Lys Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys Val Tyr 
65                  70                  75                  80  


Phe Met Lys Gln Thr Ile Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile 
                85                  90                  95      


His Ala Val Ala Asn Asn Gln Asp Lys Leu Gly Phe Glu Asp Gly Ser 
            100                 105                 110         


Val Leu Lys Gln Phe Leu Ser Glu Thr Glu Lys Met Ser Pro Glu Asp 
        115                 120                 125             


Arg Ala Lys Cys Phe Glu Lys Asn Glu Ala Ile Gln Ala Ala His Asp 
    130                 135                 140                 


Ala Val Ala Gln Glu Gly Gln Cys Arg Val Asp Asp Lys Val Asn Phe 
145                 150                 155                 160 


His Phe Ile Leu Phe Asn Asn Val Asp Gly His Leu Tyr Glu Leu Asp 
                165                 170                 175     


Gly Arg Met Pro Phe Pro Val Asn His Gly Ala Ser Ser Glu Asp Thr 
            180                 185                 190         


Leu Leu Lys Asp Ala Ala Lys Val Cys Arg Glu Phe Thr Glu Arg Glu 
        195                 200                 205             


Gln Gly Glu Val Arg Phe Ser Ala Val Ala Leu Cys Lys Ala Ala 
    210                 215                 220             


<210>  99
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Ser Gly Ala Asp Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile 
1               5                   10                  15      


Leu Lys Gln Lys Asn Arg Pro Asn Arg Leu Ile Val Asp Glu Ala Ile 
            20                  25                  30          


Asn Glu Asp Asn Ser Val Val Ser Leu Ser Gln Pro Lys Met Asp Glu 
        35                  40                  45              


Leu Gln Leu Phe Arg Gly Asp Thr Val Leu Leu Lys Gly Lys Lys Arg 
    50                  55                  60                  


Arg Glu Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser Asp Glu 
65                  70                  75                  80  


Lys Ile Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val Arg Leu 
                85                  90                  95      


Gly Asp Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys 
            100                 105                 110         


Arg Ile His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile Thr Gly 
        115                 120                 125             


Asn Leu Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg 
    130                 135                 140                 


Pro Ile Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met Arg Ala 
145                 150                 155                 160 


Val Glu Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val 
                165                 170                 175     


Ala Pro Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys Arg Glu 
            180                 185                 190         


Asp Glu Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly 
        195                 200                 205             


Cys Arg Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu Pro Leu 
    210                 215                 220                 


Arg His Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro Arg Gly 
225                 230                 235                 240 


Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg 
                245                 250                 255     


Ala Val Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro 
            260                 265                 270         


Glu Ile Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys 
        275                 280                 285             


Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp 
    290                 295                 300                 


Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu Val 
305                 310                 315                 320 


Glu Arg Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly Leu Lys 
                325                 330                 335     


Gln Arg Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro Asn Ser 
            340                 345                 350         


Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu Val Asp 
        355                 360                 365             


Ile Gly Ile Pro Asp Ala Thr Gly Arg Leu Glu Ile Leu Gln Ile His 
    370                 375                 380                 


Thr Lys Asn Met Lys Leu Ala Asp Asp Val Asp Leu Glu Gln Val Ala 
385                 390                 395                 400 


Asn Glu Thr His Gly His Val Gly Ala Asp Leu Ala Ala Leu Cys Ser 
                405                 410                 415     


Glu Ala Ala Leu Gln Ala Ile Arg Lys Lys Met Asp Leu Ile Asp Leu 
            420                 425                 430         


Glu Asp Glu Thr Ile Asp Ala Glu Val Met Asn Ser Leu Ala Val Thr 
        435                 440                 445             


Met Asp Asp Phe Arg Trp Ala Leu Ser Gln Ser Asn Pro Ser Ala Leu 
    450                 455                 460                 


Arg Glu Thr Val Val Glu Val Pro Gln Val Thr Trp Glu Asp Ile Gly 
465                 470                 475                 480 


Gly Leu Glu Asp Val Lys Arg Glu Leu Gln Glu Leu Val Gln Tyr Pro 
                485                 490                 495     


Val Glu His Pro Asp Lys Phe Leu Lys Phe Gly Met Thr Pro Ser Lys 
            500                 505                 510         


Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala 
        515                 520                 525             


Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn Phe Ile Ser Ile Lys Gly 
    530                 535                 540                 


Pro Glu Leu Leu Thr Met Trp Phe Gly Glu Ser Glu Ala Asn Val Arg 
545                 550                 555                 560 


Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala Pro Cys Val Leu Phe Phe 
                565                 570                 575     


Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg Gly Gly Asn Ile Gly Asp 
            580                 585                 590         


Gly Gly Gly Ala Ala Asp Arg Val Ile Asn Gln Ile Leu Thr Glu Met 
        595                 600                 605             


Asp Gly Met Ser Thr Lys Lys Asn Val Phe Ile Ile Gly Ala Thr Asn 
    610                 615                 620                 


Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp 
625                 630                 635                 640 


Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu Lys Ser Arg Val Ala Ile 
                645                 650                 655     


Leu Lys Ala Asn Leu Arg Lys Ser Pro Val Ala Lys Asp Val Asp Leu 
            660                 665                 670         


Glu Phe Leu Ala Lys Met Thr Asn Gly Phe Ser Gly Ala Asp Leu Thr 
        675                 680                 685             


Glu Ile Cys Gln Arg Ala Cys Lys Leu Ala Ile Arg Glu Ser Ile Glu 
    690                 695                 700                 


Ser Glu Ile Arg Arg Glu Arg Glu Arg Gln Thr Asn Pro Ser Ala Met 
705                 710                 715                 720 


Glu Val Glu Glu Asp Asp Pro Val Pro Glu Ile Arg Arg Asp His Phe 
                725                 730                 735     


Glu Glu Ala Met Arg Phe Ala Arg Arg Ser Val Ser Asp Asn Asp Ile 
            740                 745                 750         


Arg Lys Tyr Glu Met Phe Ala Gln Thr Leu Gln Gln Ser Arg Gly Phe 
        755                 760                 765             


Gly Ser Phe Arg Phe Pro Ser Gly Asn Gln Gly Gly Ala Gly Pro Ser 
    770                 775                 780                 


Gln Gly Ser Gly Gly Gly Thr Gly Gly Ser Val Tyr Thr Glu Asp Asn 
785                 790                 795                 800 


Asp Asp Asp Leu Tyr Gly 
                805     


<210>  100
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Ala Ser Leu Arg Leu Leu Gly Ala Ala Ser Gly Leu Arg Tyr 
1               5                   10                  15      


Trp Ser Arg Arg Leu Arg Pro Ala Ala Gly Ser Phe Ala Ala Val Cys 
            20                  25                  30          


Ser Arg Ser Val Ala Ser Lys Thr Pro Val Gly Phe Ile Gly Leu Gly 
        35                  40                  45              


Asn Met Gly Asn Pro Met Ala Lys Asn Leu Met Lys His Gly Tyr Pro 
    50                  55                  60                  


Leu Ile Ile Tyr Asp Val Phe Pro Asp Ala Cys Lys Glu Phe Gln Asp 
65                  70                  75                  80  


Ala Gly Glu Gln Val Val Ser Ser Pro Ala Asp Val Ala Glu Lys Ala 
                85                  90                  95      


Asp Arg Ile Ile Thr Met Leu Pro Thr Ser Ile Asn Ala Ile Glu Ala 
            100                 105                 110         


Tyr Ser Gly Ala Asn Gly Ile Leu Lys Lys Val Lys Lys Gly Ser Leu 
        115                 120                 125             


Leu Ile Asp Ser Ser Thr Ile Asp Pro Ala Val Ser Lys Glu Leu Ala 
    130                 135                 140                 


Lys Glu Val Glu Lys Met Gly Ala Val Phe Met Asp Ala Pro Val Ser 
145                 150                 155                 160 


Gly Gly Val Gly Ala Ala Arg Ser Gly Asn Leu Thr Phe Met Val Gly 
                165                 170                 175     


Gly Val Glu Asp Glu Phe Ala Ala Ala Gln Glu Leu Leu Gly Cys Met 
            180                 185                 190         


Gly Ser Asn Val Val Tyr Cys Gly Ala Val Gly Thr Gly Gln Ala Ala 
        195                 200                 205             


Lys Ile Cys Asn Asn Met Leu Leu Ala Ile Ser Met Ile Gly Thr Ala 
    210                 215                 220                 


Glu Ala Met Asn Leu Gly Ile Arg Leu Gly Leu Asp Pro Lys Leu Leu 
225                 230                 235                 240 


Ala Lys Ile Leu Asn Met Ser Ser Gly Arg Cys Trp Ser Ser Asp Thr 
                245                 250                 255     


Tyr Asn Pro Val Pro Gly Val Met Asp Gly Val Pro Ser Ala Asn Asn 
            260                 265                 270         


Tyr Gln Gly Gly Phe Gly Thr Thr Leu Met Ala Lys Asp Leu Gly Leu 
        275                 280                 285             


Ala Gln Asp Ser Ala Thr Ser Thr Lys Ser Pro Ile Leu Leu Gly Ser 
    290                 295                 300                 


Leu Ala His Gln Ile Tyr Arg Met Met Cys Ala Lys Gly Tyr Ser Lys 
305                 310                 315                 320 


Lys Asp Phe Ser Ser Val Phe Gln Phe Leu Arg Glu Glu Glu Thr Phe 
                325                 330                 335     


<210>  101
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Val Ala Val Leu Gly Gly Arg Gly Val Leu Arg Leu Arg Leu Leu 
1               5                   10                  15      


Leu Ser Ala Leu Lys Pro Gly Ile His Val Pro Arg Ala Gly Pro Ala 
            20                  25                  30          


Ala Ala Phe Gly Thr Ser Val Thr Ser Ala Lys Val Ala Val Asn Gly 
        35                  40                  45              


Val Gln Leu His Tyr Gln Gln Thr Gly Glu Gly Asp His Ala Val Leu 
    50                  55                  60                  


Leu Leu Pro Gly Met Leu Gly Ser Gly Glu Thr Asp Phe Gly Pro Gln 
65                  70                  75                  80  


Leu Lys Asn Leu Asn Lys Lys Leu Phe Thr Val Val Ala Trp Asp Pro 
                85                  90                  95      


Arg Gly Tyr Gly His Ser Arg Pro Pro Asp Arg Asp Phe Pro Ala Asp 
            100                 105                 110         


Phe Phe Glu Arg Asp Ala Lys Asp Ala Val Asp Leu Met Lys Ala Leu 
        115                 120                 125             


Lys Phe Lys Lys Val Ser Leu Leu Gly Trp Ser Asp Gly Gly Ile Thr 
    130                 135                 140                 


Ala Leu Ile Ala Ala Ala Lys Tyr Pro Ser Tyr Ile His Lys Met Val 
145                 150                 155                 160 


Ile Trp Gly Ala Asn Ala Tyr Val Thr Asp Glu Asp Ser Met Ile Tyr 
                165                 170                 175     


Glu Gly Ile Arg Asp Val Ser Lys Trp Ser Glu Arg Thr Arg Lys Pro 
            180                 185                 190         


Leu Glu Ala Leu Tyr Gly Tyr Asp Tyr Phe Ala Arg Thr Cys Glu Lys 
        195                 200                 205             


Trp Val Asp Gly Ile Arg Gln Phe Lys His Leu Pro Asp Gly Asn Ile 
    210                 215                 220                 


Cys Arg His Leu Leu Pro Arg Val Gln Cys Pro Ala Leu Ile Val His 
225                 230                 235                 240 


Gly Glu Lys Asp Pro Leu Val Pro Arg Phe His Ala Asp Phe Ile His 
                245                 250                 255     


Lys His Val Lys Gly Ser Arg Leu His Leu Met Pro Glu Gly Lys His 
            260                 265                 270         


Asn Leu His Leu Arg Phe Ala Asp Glu Phe Asn Lys Leu Ala Glu Asp 
        275                 280                 285             


Phe Leu Gln 
    290     


<210>  102
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Ala Cys Arg Ala Leu Lys Ala Val Leu Val Asp Leu Ser Gly 
1               5                   10                  15      


Thr Leu His Ile Glu Asp Ala Ala Val Pro Gly Ala Gln Glu Ala Leu 
            20                  25                  30          


Lys Arg Leu Arg Gly Ala Ser Val Ile Ile Arg Phe Val Thr Asn Thr 
        35                  40                  45              


Thr Lys Glu Ser Lys Gln Asp Leu Leu Glu Arg Leu Arg Lys Leu Glu 
    50                  55                  60                  


Phe Asp Ile Ser Glu Asp Glu Ile Phe Thr Ser Leu Thr Ala Ala Arg 
65                  70                  75                  80  


Ser Leu Leu Glu Arg Lys Gln Val Arg Pro Met Leu Leu Val Asp Asp 
                85                  90                  95      


Arg Ala Leu Pro Asp Phe Lys Gly Ile Gln Thr Ser Asp Pro Asn Ala 
            100                 105                 110         


Val Val Met Gly Leu Ala Pro Glu His Phe His Tyr Gln Ile Leu Asn 
        115                 120                 125             


Gln Ala Phe Arg Leu Leu Leu Asp Gly Ala Pro Leu Ile Ala Ile His 
    130                 135                 140                 


Lys Ala Arg Tyr Tyr Lys Arg Lys Asp Gly Leu Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Pro Phe Val Thr Ala Leu Glu Tyr Ala Thr Asp Thr Lys Ala Thr Val 
                165                 170                 175     


Val Gly Lys Pro Glu Lys Thr Phe Phe Leu Glu Ala Leu Arg Gly Thr 
            180                 185                 190         


Gly Cys Glu Pro Glu Glu Ala Val Met Ile Gly Asp Asp Cys Arg Asp 
        195                 200                 205             


Asp Val Gly Gly Ala Gln Asp Val Gly Met Leu Gly Ile Leu Val Lys 
    210                 215                 220                 


Thr Gly Lys Tyr Arg Ala Ser Asp Glu Glu Lys Ile Asn Pro Pro Pro 
225                 230                 235                 240 


Tyr Leu Thr Cys Glu Ser Phe Pro His Ala Val Asp His Ile Leu Gln 
                245                 250                 255     


His Leu Leu 
            


<210>  103
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  104
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  105
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Gly Trp Gln Ser Tyr Val Asp Asn Leu Met Cys Asp Gly Cys 
1               5                   10                  15      


Cys Gln Glu Ala Ala Ile Val Gly Tyr Cys Asp Ala Lys Tyr Val Trp 
            20                  25                  30          


Ala Ala Thr Ala Gly Gly Val Phe Gln Ser Ile Thr Pro Ile Glu Ile 
        35                  40                  45              


Asp Met Ile Val Gly Lys Asp Arg Glu Gly Phe Phe Thr Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Ala Lys Lys Cys Ser Val Ile Arg Asp Ser Leu Tyr Val 
65                  70                  75                  80  


Asp Gly Asp Cys Thr Met Asp Ile Arg Thr Lys Ser Gln Gly Gly Glu 
                85                  90                  95      


Pro Thr Tyr Asn Val Ala Val Gly Arg Ala Gly Arg Val Leu Val Phe 
            100                 105                 110         


Val Met Gly Lys Glu Gly Val His Gly Gly Gly Leu Asn Lys Lys Ala 
        115                 120                 125             


Tyr Ser Met Ala Lys Tyr Leu Arg Asp Ser Gly Phe 
    130                 135                 140 


<210>  106
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Gly Trp Gln Ser Tyr Val Asp Asn Leu Met Cys Asp Gly Cys 
1               5                   10                  15      


Cys Gln Glu Ala Ala Ile Val Gly Tyr Cys Asp Ala Lys Tyr Val Trp 
            20                  25                  30          


Ala Ala Thr Ala Gly Gly Val Phe Gln Ser Ile Thr Pro Ile Glu Ile 
        35                  40                  45              


Asp Met Ile Val Gly Lys Asp Arg Glu Gly Phe Phe Thr Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Ala Lys Lys Cys Ser Val Ile Arg Asp Ser Leu Tyr Val 
65                  70                  75                  80  


Asp Gly Asp Cys Thr Met Asp Ile Arg Thr Lys Ser Gln Gly Gly Glu 
                85                  90                  95      


Pro Thr Tyr Asn Val Ala Val Gly Arg Ala Gly Arg Ala Leu Val Ile 
            100                 105                 110         


Val Met Gly Lys Glu Gly Val His Gly Gly Thr Leu Asn Lys Lys Ala 
        115                 120                 125             


Tyr Glu Leu Ala Leu Tyr Leu Arg Arg Ser Asp Val 
    130                 135                 140 


<210>  107
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Asn Arg Gly Pro Ser Tyr Gly Leu Ser Arg Glu Val Gln Glu 
1               5                   10                  15      


Lys Ile Glu Gln Lys Tyr Asp Ala Asp Leu Glu Asn Lys Leu Val Asp 
            20                  25                  30          


Trp Ile Ile Leu Gln Cys Ala Glu Asp Ile Glu His Pro Pro Pro Gly 
        35                  40                  45              


Arg Ala His Phe Gln Lys Trp Leu Met Asp Gly Thr Val Leu Cys Lys 
    50                  55                  60                  


Leu Ile Asn Ser Leu Tyr Pro Pro Gly Gln Glu Pro Ile Pro Lys Ile 
65                  70                  75                  80  


Ser Glu Ser Lys Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 
                85                  90                  95      


Leu Lys Ala Ala Glu Thr Tyr Gly Val Arg Thr Thr Asp Ile Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Trp Glu Gly Lys Asp Met Ala Ala Val Gln Arg Thr 
        115                 120                 125             


Leu Met Ala Leu Gly Ser Val Ala Val Thr Lys Asp Asp Gly Cys Tyr 
    130                 135                 140                 


Arg Gly Glu Pro Ser Trp Phe His Arg Lys Ala Gln Gln Asn Arg Arg 
145                 150                 155                 160 


Gly Phe Ser Glu Glu Gln Leu Arg Gln Gly Gln Asn Val Ile Gly Leu 
                165                 170                 175     


Gln Met Gly Ser Asn Lys Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 
            180                 185                 190         


Gly Met Pro Arg Gln Ile Met 
        195                 


<210>  108
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp 
    


<210>  109
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Glu Ile Ala Asp 
        515                 520                 525             


Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu Thr Arg Phe Met Thr Ile 
    530                 535                 540                 


Leu Cys Thr Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln Glu Phe 
545                 550                 555                 560 


Ile Lys Met Thr Asn Tyr Asp Val Glu His Thr Ile Lys Lys Glu Met 
                565                 570                 575     


Ser Gly Asp Val Arg Asp Ala Phe Val Ala Ile Val Gln Ser Val Lys 
            580                 585                 590         


Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu Tyr Lys Ser Met Lys Gly 
        595                 600                 605             


Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg Ile Met Val Ser Arg Ser 
    610                 615                 620                 


Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp 
625                 630                 635                 640 


Lys Ser Leu His Gln Ala Ile Glu Gly Asp Thr Ser Gly Asp Phe Leu 
                645                 650                 655     


Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu Asp 
            660                 665         


<210>  110
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ser Ser Ser Tyr Arg 
1               5                   10                  15      


Lys Val Phe Gly Asp Gly Ser Arg Leu Ser Ala Arg Leu Ser Gly Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val 
        35                  40                  45              


Ala Ser Ser Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu 
    50                  55                  60                  


Ala Tyr Arg Arg Pro Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala 
65                  70                  75                  80  


Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu 
                85                  90                  95      


Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val 
            100                 105                 110         


His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala 
        115                 120                 125             


Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln 
    130                 135                 140                 


Arg Glu Leu Arg Asp Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala 
145                 150                 155                 160 


Arg Ser Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln 
                165                 170                 175     


Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala 
            180                 185                 190         


Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu 
        195                 200                 205             


Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Thr Val 
                245                 250                 255     


Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr 
            260                 265                 270         


Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys 
        275                 280                 285             


Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala 
    290                 295                 300                 


Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln 
305                 310                 315                 320 


Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu 
                325                 330                 335     


Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala 
            340                 345                 350         


Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Asn Asp Leu Arg Asn Thr 
        355                 360                 365             


Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn 
    370                 375                 380                 


Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Glu Thr Arg Phe Ser Thr Ser Gly Leu Ser Ile Ser Gly 
                405                 410                 415     


Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu 
            420                 425                 430         


Ser Ala Thr Thr Ser Lys Val Ser Ser Thr Gly Leu Ser Leu Lys Lys 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Ala Ser Lys Val Ala Ser Lys Lys Thr Ser 
    450                 455                 460                 


Gln Ile Gly Glu Ser Phe Glu Glu Ile Leu Glu Glu Thr Val Ile Ser 
465                 470                 475                 480 


Thr Lys Lys Thr Glu Lys Ser Asn Ile Glu Glu Thr Thr Ile Ser Ser 
                485                 490                 495     


Gln Lys Ile 
            


<210>  111
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ser Ser Phe Ser Tyr Glu Pro Tyr Tyr Ser Thr Ser Tyr Lys Arg 
1               5                   10                  15      


Arg Tyr Val Glu Thr Pro Arg Val His Ile Ser Ser Val Arg Ser Gly 
            20                  25                  30          


Tyr Ser Thr Ala Arg Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser 
        35                  40                  45              


Ser Ser Leu Ser Val Arg Arg Ser Tyr Ser Ser Ser Ser Gly Ser Leu 
    50                  55                  60                  


Met Pro Ser Leu Glu Asn Leu Asp Leu Ser Gln Val Ala Ala Ile Ser 
65                  70                  75                  80  


Asn Asp Leu Lys Ser Ile Arg Thr Gln Glu Lys Ala Gln Leu Gln Asp 
                85                  90                  95      


Leu Asn Asp Arg Phe Ala Ser Phe Ile Glu Arg Val His Glu Leu Glu 
            100                 105                 110         


Gln Gln Asn Lys Val Leu Glu Ala Glu Leu Leu Val Leu Arg Gln Lys 
        115                 120                 125             


His Ser Glu Pro Ser Arg Phe Arg Ala Leu Tyr Glu Gln Glu Ile Arg 
    130                 135                 140                 


Asp Leu Arg Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys Gln Ala Leu 
145                 150                 155                 160 


Gln Gly Glu Arg Glu Gly Leu Glu Glu Thr Leu Arg Asn Leu Gln Ala 
                165                 170                 175     


Arg Tyr Glu Glu Glu Val Leu Ser Arg Glu Asp Ala Glu Gly Arg Leu 
            180                 185                 190         


Met Glu Ala Arg Lys Gly Ala Asp Glu Ala Ala Leu Ala Arg Ala Glu 
        195                 200                 205             


Leu Glu Lys Arg Ile Asp Ser Leu Met Asp Glu Ile Ser Phe Leu Lys 
    210                 215                 220                 


Lys Val His Glu Glu Glu Ile Ala Glu Leu Gln Ala Gln Ile Gln Tyr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Glu Met Asp Val Thr Lys Pro Asp Leu Ser Ala 
                245                 250                 255     


Ala Leu Lys Asp Ile Arg Ala Gln Tyr Glu Lys Leu Ala Ala Lys Asn 
            260                 265                 270         


Met Gln Asn Ala Glu Glu Trp Phe Lys Ser Arg Phe Thr Val Leu Thr 
        275                 280                 285             


Glu Ser Ala Ala Lys Asn Thr Asp Ala Val Arg Ala Ala Lys Asp Glu 
    290                 295                 300                 


Val Ser Glu Ser Arg Arg Leu Leu Lys Ala Lys Thr Leu Glu Ile Glu 
305                 310                 315                 320 


Ala Cys Arg Gly Met Asn Glu Ala Leu Glu Lys Gln Leu Gln Glu Leu 
                325                 330                 335     


Glu Asp Lys Gln Asn Ala Asp Ile Ser Ala Met Gln Asp Thr Ile Asn 
            340                 345                 350         


Lys Leu Glu Asn Glu Leu Arg Thr Thr Lys Ser Glu Met Ala Arg Tyr 
        355                 360                 365             


Leu Lys Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile 
    370                 375                 380                 


Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg Leu 
385                 390                 395                 400 


Ser Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser Ser 
                405                 410                 415     


Gln Val Phe Gly Arg Ser Ala Tyr Gly Gly Leu Gln Thr Ser Ser Tyr 
            420                 425                 430         


Leu Met Ser Thr Arg Ser Phe Pro Ser Tyr Tyr Thr Ser His Val Gln 
        435                 440                 445             


Glu Glu Gln Ile Glu Val Glu Glu Thr Ile Glu Ala Ala Lys Ala Glu 
    450                 455                 460                 


Glu Ala Lys Asp Glu Pro Pro Ser Glu Gly Glu Ala Glu Glu Glu Glu 
465                 470                 475                 480 


Lys Asp Lys Glu Glu Ala Glu Glu Glu Glu Ala Ala Glu Glu Glu Glu 
                485                 490                 495     


Ala Ala Lys Glu Glu Ser Glu Glu Ala Lys Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Glu Gly Glu Glu Gly Glu Glu Thr Lys Glu Ala Glu Glu Glu Glu Lys 
        515                 520                 525             


Lys Val Glu Gly Ala Gly Glu Glu Gln Ala Ala Lys Lys Lys Asp 
    530                 535                 540             


<210>  112
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  113
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Gly Gly Lys Ser Thr Lys Asp Gly Glu Asn 
385                 390                 395                 400 


His Lys Val Thr Arg Tyr Leu Lys Ser Leu Thr Ile Arg Val Ile Pro 
                405                 410                 415     


Ile Gln Ala His Gln Ile Val Asn Gly Thr Pro Pro Ala Arg Gly 
            420                 425                 430     


<210>  114
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  115
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Asn Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu 
            420                 425                 430         


Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala 
        435                 440                 445 


<210>  116
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  117
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 
65                  70                  75                  80  


Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp 
    130                 135                 140                 


His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 
                165                 170                 175     


Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu 
        195                 200                 205             


Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 
            260                 265                 270         


Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 
305                 310                 315                 320 


Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 
                405                 410                 415     


Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 
        435                 440                 445             


Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 
    450                 455                 460                 


Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 
            500                 505                 510         


Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 
    530                 535                 540                 


Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 
                565                 570         


<210>  118
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Ser Phe Gln Gly Lys Lys Ser Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Arg Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Val His Val Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Ile Lys Thr Ile Asp Ala His Gly Leu Met 
    50                  55                  60                  


Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln Met Pro Val 
65                  70                  75                  80  


Leu Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe Pro Asp Thr 
            100                 105                 110         


Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Glu Arg Ala Asp 
        115                 120                 125             


Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Arg Trp 
    130                 135                 140                 


His Glu Ser Ile Lys Glu Glu Leu Glu Ala Leu Val Lys Glu Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg Cys Gln Cys 
                165                 170                 175     


Ser Asp Ser Gln Met Tyr Glu Ile Phe Ser Ile Ile Arg Asp Leu Gly 
            180                 185                 190         


Ala Leu Ala Gln Val His Ala Glu Asn Gly Asp Ile Val Glu Glu Glu 
        195                 200                 205             


Gln Lys Arg Leu Leu Glu Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala Val 
225                 230                 235                 240 


Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Gly Ala Ala Asp Ala Ile Ala Gln Ala Lys Arg Arg Gly Val 
            260                 265                 270         


Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Val Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Cys Leu 
305                 310                 315                 320 


Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Ala Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Ile Glu Glu Arg Met Ser Met Val Trp Glu Lys 
        355                 360                 365             


Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Lys Ala 
                405                 410                 415     


Thr Lys Ile Ile Ser Ala Lys Thr His Asn Leu Asn Val Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Val Glu Cys Arg Gly Ala Pro Ala Val Val Ile Ser 
        435                 440                 445             


Gln Gly Arg Val Ala Leu Glu Asp Gly Lys Met Phe Val Thr Pro Gly 
    450                 455                 460                 


Ala Gly Arg Phe Val Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Val Pro Ala Lys Pro 
            500                 505                 510         


Gly Ser Gly Ala Pro Ala Arg Ala Ser Cys Pro Gly Lys Ile Ser Val 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ser 
    530                 535                 540                 


Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
                565                 570         


<210>  119
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu 
            20                  25                  30          


Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 
        35                  40                  45              


Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 
    50                  55                  60                  


Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 
65                  70                  75                  80  


Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala 
                85                  90                  95      


Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 
            100                 105                 110         


Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 
    130                 135                 140                 


Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln 
145                 150                 155                 160 


Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 
                165                 170                 175     


Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala 
            180                 185                 190         


Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 
        195                 200                 205             


Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr 
    210                 215                 220                 


Val Lys Glu 
225         


<210>  120
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
            20                  25                  30          


Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                85                  90                  95      


Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
        115                 120                 125             


Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
    130                 135                 140                 


Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
145                 150                 155                 160 


Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 
                165                 170                 175     


Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
            180                 185                 190         


Val Lys Pro Ala Gly Gly Gly Cys Cys 
        195                 200     


<210>  121
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Ala Ser Ala Thr Asp Ser Arg Tyr Gly Gln Lys Glu Ser Ser Asp 
1               5                   10                  15      


Gln Asn Phe Asp Tyr Met Phe Lys Ile Leu Ile Ile Gly Asn Ser Ser 
            20                  25                  30          


Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
        35                  40                  45              


Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Ile 
    50                  55                  60                  


Tyr Arg Asn Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
65                  70                  75                  80  


Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                85                  90                  95      


Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
            100                 105                 110         


Val Gln Asp Trp Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
        115                 120                 125             


Gln Val Leu Leu Val Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val 
    130                 135                 140                 


Val Ser Ser Glu Arg Gly Arg Gln Leu Ala Asp His Leu Gly Phe Glu 
145                 150                 155                 160 


Phe Phe Glu Ala Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe 
                165                 170                 175     


Glu Arg Leu Val Asp Val Ile Cys Glu Lys Met Ser Glu Ser Leu Asp 
            180                 185                 190         


Thr Ala Asp Pro Ala Val Thr Gly Ala Lys Gln Gly Pro Gln Leu Ser 
        195                 200                 205             


Asp Gln Gln Val Pro Pro His Gln Asp Cys Ala Cys 
    210                 215                 220 


<210>  122
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ser Thr Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Ile Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Ala Ala Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Val Asn Ser Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys 
    130                 135                 140                 


Ala Lys Glu Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Ser Thr Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Glu Lys Pro Gln Glu Gln Pro Val Ser Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210>  123
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Asp Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu 
1               5                   10                  15      


Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His 
            20                  25                  30          


Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ser Ser Ile Thr Pro 
        35                  40                  45              


Leu Glu Glu Leu Tyr Lys Arg Phe Gln Leu Leu Glu Gly Pro Pro Glu 
    50                  55                  60                  


Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe 
65                  70                  75                  80  


Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val 
                85                  90                  95      


Thr Arg Tyr Leu Asp Phe Lys Val Val Glu Gly Ser Phe Val Tyr Lys 
            100                 105                 110         


Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Thr Glu Ala Leu Ala 
        115                 120                 125             


Ser Asn Leu Met Gly Met Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu 
    130                 135                 140                 


Val Phe Val Ala Asn Phe Asp Glu Asn Asp Pro Lys Thr Phe Glu Gly 
145                 150                 155                 160 


Val Asp Pro Gln Thr Thr Ser Met Arg Asp Val Tyr Arg Lys Phe Asp 
                165                 170                 175     


Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr 
            180                 185                 190         


Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Leu Glu Thr Val Asn Arg 
        195                 200                 205             


Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr 
    210                 215                 220                 


Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg 
225                 230                 235                 240 


Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Val Asp 
                245                 250                 255     


Asp Ile Ile Met Glu Asn Gly Lys Val Val Gly Val Lys Ser Glu Gly 
            260                 265                 270         


Glu Val Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Ile Pro 
        275                 280                 285             


Asp Arg Val Arg Lys Ala Gly Gln Val Ile Arg Ile Ile Cys Ile Leu 
    290                 295                 300                 


Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile 
305                 310                 315                 320 


Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met 
                325                 330                 335     


Ile Ser Tyr Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile 
            340                 345                 350         


Ala Ser Thr Thr Val Glu Thr Thr Asp Pro Glu Lys Glu Val Glu Pro 
        355                 360                 365             


Ala Leu Glu Leu Leu Glu Pro Ile Asp Gln Lys Phe Val Ala Ile Ser 
    370                 375                 380                 


Asp Leu Tyr Glu Pro Ile Asp Asp Gly Cys Glu Ser Gln Val Phe Cys 
385                 390                 395                 400 


Ser Cys Ser Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asn Asp 
                405                 410                 415     


Ile Lys Asp Ile Tyr Lys Arg Met Ala Gly Thr Ala Phe Asp Phe Glu 
            420                 425                 430         


Asn Met Lys Arg Lys Gln Asn Asp Val Phe Gly Glu Ala Glu Gln 
        435                 440                 445         


<210>  124
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Asp Asn Ala Gly Lys Glu Arg Glu Ala Val Gln Leu Met Ala Glu 
1               5                   10                  15      


Ala Glu Lys Arg Val Lys Ala Ser His Ser Phe Leu Arg Gly Leu Phe 
            20                  25                  30          


Gly Gly Asn Thr Arg Ile Glu Glu Ala Cys Glu Met Tyr Thr Arg Ala 
        35                  40                  45              


Ala Asn Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala 
    50                  55                  60                  


Phe Cys Gln Ala Ala Lys Leu His Met Gln Leu Gln Ser Lys His Asp 
65                  70                  75                  80  


Ser Ala Thr Ser Phe Val Asp Ala Gly Asn Ala Tyr Lys Lys Ala Asp 
                85                  90                  95      


Pro Gln Glu Ala Ile Asn Cys Leu Asn Ala Ala Ile Asp Ile Tyr Thr 
            100                 105                 110         


Asp Met Gly Arg Phe Thr Ile Ala Ala Lys His His Ile Thr Ile Ala 
        115                 120                 125             


Glu Ile Tyr Glu Thr Glu Leu Val Asp Ile Glu Lys Ala Ile Ala His 
    130                 135                 140                 


Tyr Glu Gln Ser Ala Asp Tyr Tyr Lys Gly Glu Glu Ser Asn Ser Ser 
145                 150                 155                 160 


Ala Asn Lys Cys Leu Leu Lys Val Ala Ala Tyr Ala Ala Gln Leu Glu 
                165                 170                 175     


Gln Tyr Gln Lys Ala Ile Glu Ile Tyr Glu Gln Val Gly Ala Asn Thr 
            180                 185                 190         


Met Asp Asn Pro Leu Leu Lys Tyr Ser Ala Lys Asp Tyr Phe Phe Lys 
        195                 200                 205             


Ala Ala Leu Cys His Phe Ile Val Asp Glu Leu Asn Ala Lys Leu Ala 
    210                 215                 220                 


Leu Glu Lys Tyr Glu Glu Met Phe Pro Ala Phe Thr Asp Ser Arg Glu 
225                 230                 235                 240 


Cys Lys Leu Leu Lys Lys Leu Leu Glu Ala His Glu Glu Gln Asn Ser 
                245                 250                 255     


Glu Ala Tyr Thr Glu Ala Val Lys Glu Phe Asp Ser Ile Ser Arg Leu 
            260                 265                 270         


Asp Gln Trp Leu Thr Thr Met Leu Leu Arg Ile Lys Lys Ser Ile Gln 
        275                 280                 285             


Gly Asp Gly Glu Gly Asp Gly Asp Leu Lys 
    290                 295             


<210>  125
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  126
<211>  170
<212>  PRT
<213>  Mus musculus

<400>  126

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  127
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  128
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe 
1               5                   10                  15      


Phe Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu 
            20                  25                  30          


Gly Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys 
        35                  40                  45              


Lys Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln 
    50                  55                  60                  


Tyr Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His 
65                  70                  75                  80  


Val Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln 
                85                  90                  95      


Leu Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr 
            100                 105                 110         


Asp His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys 
        115                 120                 125             


Asp Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala 
    130                 135                 140                 


Glu Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly 
145                 150                 155                 160 


Lys Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn 
                165                 170                 175     


Phe Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn 
            180                 185                 190         


Lys Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu 
        195                 200                 205             


Asn Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln 
    210                 215                 220                 


Asp Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala 
225                 230                 235                 240 


Leu Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu 
                245                 250                 255     


Cys Ala Gly Asp Asn 
            260     


<210>  129
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ala Gly Pro Gln Gln Gln Pro Pro Tyr Leu His Leu Ala Glu Leu 
1               5                   10                  15      


Thr Ala Ser Gln Phe Leu Glu Ile Trp Lys His Phe Asp Ala Asp Gly 
            20                  25                  30          


Asn Gly Tyr Ile Glu Gly Lys Glu Leu Glu Asn Phe Phe Gln Glu Leu 
        35                  40                  45              


Glu Lys Ala Arg Lys Gly Ser Gly Met Met Ser Lys Ser Asp Asn Phe 
    50                  55                  60                  


Gly Glu Lys Met Lys Glu Phe Met Gln Lys Tyr Asp Lys Asn Ser Asp 
65                  70                  75                  80  


Gly Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu 
                85                  90                  95      


Asn Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe 
            100                 105                 110         


Met Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu 
        115                 120                 125             


Ala Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn 
    130                 135                 140                 


Arg Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu 
145                 150                 155                 160 


Arg Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met 
                165                 170                 175     


Ser Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly 
            180                 185                 190         


Met Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp 
        195                 200                 205             


Lys Asp Arg Ser Gly Tyr Ile Asp Glu His Glu Leu Asp Ala Leu Leu 
    210                 215                 220                 


Lys Asp Leu Tyr Glu Lys Asn Lys Lys Glu Met Asn Ile Gln Gln Leu 
225                 230                 235                 240 


Thr Asn Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu 
                245                 250                 255     


Tyr Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Met 
            260                 265                 270     


<210>  130
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Gly Lys Gln Asn Ser Lys Leu Ala Pro Glu Val Met Glu Asp Leu 
1               5                   10                  15      


Val Lys Ser Thr Glu Phe Asn Glu His Glu Leu Lys Gln Trp Tyr Lys 
            20                  25                  30          


Gly Phe Leu Lys Asp Cys Pro Ser Gly Arg Leu Asn Leu Glu Glu Phe 
        35                  40                  45              


Gln Gln Leu Tyr Val Lys Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
    50                  55                  60                  


Ala Gln His Ala Phe Arg Thr Phe Asp Lys Asn Gly Asp Gly Thr Ile 
65                  70                  75                  80  


Asp Phe Arg Glu Phe Ile Cys Ala Leu Ser Ile Thr Ser Arg Gly Ser 
                85                  90                  95      


Phe Glu Gln Lys Leu Asn Trp Ala Phe Asn Met Tyr Asp Leu Asp Gly 
            100                 105                 110         


Asp Gly Lys Ile Thr Arg Val Glu Met Leu Glu Ile Ile Glu Ala Ile 
        115                 120                 125             


Tyr Lys Met Val Gly Thr Val Ile Met Met Lys Met Asn Glu Asp Gly 
    130                 135                 140                 


Leu Thr Pro Glu Gln Arg Val Asp Lys Ile Phe Ser Lys Met Asp Lys 
145                 150                 155                 160 


Asn Lys Asp Asp Gln Ile Thr Leu Asp Glu Phe Lys Glu Ala Ala Lys 
                165                 170                 175     


Ser Asp Pro Ser Ile Val Leu Leu Leu Gln Cys Asp Ile Gln Lys 
            180                 185                 190     


<210>  131
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ala Leu Ser Met Pro Leu Asn Gly Leu Lys Glu Glu Asp Lys Glu 
1               5                   10                  15      


Pro Leu Ile Glu Leu Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile 
            20                  25                  30          


Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp Leu Lys 
        35                  40                  45              


Gly Val Val Phe Ser Val Thr Thr Val Asp Leu Lys Arg Lys Pro Ala 
    50                  55                  60                  


Asp Leu Gln Asn Leu Ala Pro Gly Thr His Pro Pro Phe Ile Thr Phe 
65                  70                  75                  80  


Asn Ser Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe Leu Glu 
                85                  90                  95      


Glu Val Leu Cys Pro Pro Lys Tyr Leu Lys Leu Ser Pro Lys His Pro 
            100                 105                 110         


Glu Ser Asn Thr Ala Gly Met Asp Ile Phe Ala Lys Phe Ser Ala Tyr 
        115                 120                 125             


Ile Lys Asn Ser Arg Pro Glu Ala Asn Glu Ala Leu Glu Arg Gly Leu 
    130                 135                 140                 


Leu Lys Thr Leu Gln Lys Leu Asp Glu Tyr Leu Asn Ser Pro Leu Pro 
145                 150                 155                 160 


Asp Glu Ile Asp Glu Asn Ser Met Glu Asp Ile Lys Phe Ser Thr Arg 
                165                 170                 175     


Lys Phe Leu Asp Gly Asn Glu Met Thr Leu Ala Asp Cys Asn Leu Leu 
            180                 185                 190         


Pro Lys Leu His Ile Val Lys Val Val Ala Lys Lys Tyr Arg Asn Phe 
        195                 200                 205             


Asp Ile Pro Lys Glu Met Thr Gly Ile Trp Arg Tyr Leu Thr Asn Ala 
    210                 215                 220                 


Tyr Ser Arg Asp Glu Phe Thr Asn Thr Cys Pro Ser Asp Lys Glu Val 
225                 230                 235                 240 


Glu Ile Ala Tyr Ser Asp Val Ala Lys Arg Leu Thr Lys 
                245                 250             


<210>  132
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu Gln Glu 
1               5                   10                  15      


Val Asp Glu Gln Pro Gln His Pro Leu His Val Thr Tyr Ala Gly Ala 
            20                  25                  30          


Ala Val Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Lys Asn 
        35                  40                  45              


Arg Pro Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu Tyr 
    50                  55                  60                  


Thr Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys 
65                  70                  75                  80  


Tyr Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp 
                85                  90                  95      


Ile Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro 
            100                 105                 110         


Lys Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Asp 
        115                 120                 125             


Arg Pro Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly Asp 
    130                 135                 140                 


His Arg Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu Leu 
145                 150                 155                 160 


Arg Ala Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp Tyr 
                165                 170                 175     


Val Pro Lys Leu Tyr Glu Gln Leu Ser Gly Lys 
            180                 185         


<210>  133
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  134
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  135
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  136
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His 
1               5                   10                  15      


Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro 
            20                  25                  30          


Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser 
        35                  40                  45              


Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro Ala 
    50                  55                  60                  


Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly 
65                  70                  75                  80  


Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu Val 
                85                  90                  95      


Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
            100                 105                 110         


Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu 
        115                 120                 125             


Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp Ile 
    130                 135                 140                 


Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu 
145                 150                 155                 160 


Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu Leu 
                165                 170                 175     


Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn 
            180                 185                 190         


Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser 
        195                 200                 205             


Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Tyr Val Glu Thr 
    210                 215                 220                 


His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile 
225                 230                 235                 240 


Lys Pro Ser Pro Ala Ala Ser Lys Glu Tyr Phe Gln Lys Val Asn Gln 
                245                 250                 255     


<210>  137
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Glu Glu Glu Cys Arg Val Leu Ser Ile Gln Ser His Val Ile Arg 
1               5                   10                  15      


Gly Tyr Val Gly Asn Arg Ala Ala Thr Phe Pro Leu Gln Val Leu Gly 
            20                  25                  30          


Phe Glu Ile Asp Ala Val Asn Ser Val Gln Phe Ser Asn His Thr Gly 
        35                  40                  45              


Tyr Ala His Trp Lys Gly Gln Val Leu Asn Ser Asp Glu Leu Gln Glu 
    50                  55                  60                  


Leu Tyr Glu Gly Leu Arg Leu Asn Asn Met Asn Lys Tyr Asp Tyr Val 
65                  70                  75                  80  


Leu Thr Gly Tyr Thr Arg Asp Lys Ser Phe Leu Ala Met Val Val Asp 
                85                  90                  95      


Ile Val Gln Glu Leu Lys Gln Gln Asn Pro Arg Leu Val Tyr Val Cys 
            100                 105                 110         


Asp Pro Val Leu Gly Asp Lys Trp Asp Gly Glu Gly Ser Met Tyr Val 
        115                 120                 125             


Pro Glu Asp Leu Leu Pro Val Tyr Lys Glu Lys Val Val Pro Leu Ala 
    130                 135                 140                 


Asp Ile Ile Thr Pro Asn Gln Phe Glu Ala Glu Leu Leu Ser Gly Arg 
145                 150                 155                 160 


Lys Ile His Ser Gln Glu Glu Ala Leu Arg Val Met Asp Met Leu His 
                165                 170                 175     


Ser Met Gly Pro Asp Thr Val Val Ile Thr Ser Ser Asp Leu Pro Ser 
            180                 185                 190         


Pro Gln Gly Ser Asn Tyr Leu Ile Val Leu Gly Ser Gln Arg Arg Arg 
        195                 200                 205             


Asn Pro Ala Gly Ser Val Val Met Glu Arg Ile Arg Met Asp Ile Arg 
    210                 215                 220                 


Lys Val Asp Ala Val Phe Val Gly Thr Gly Asp Leu Phe Ala Ala Met 
225                 230                 235                 240 


Leu Leu Ala Trp Thr His Lys His Pro Asn Asn Leu Lys Val Ala Cys 
                245                 250                 255     


Glu Lys Thr Val Ser Thr Leu His His Val Leu Gln Arg Thr Ile Gln 
            260                 265                 270         


Cys Ala Lys Ala Gln Ala Gly Glu Gly Val Arg Pro Ser Pro Met Gln 
        275                 280                 285             


Leu Glu Leu Arg Met Val Gln Ser Lys Arg Asp Ile Glu Asp Pro Glu 
    290                 295                 300                 


Ile Val Val Gln Ala Thr Val Leu 
305                 310         


<210>  138
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  139
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Lys Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Ile Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Ser Ala Phe Thr Glu Ala Val Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Tyr Glu Ser Lys Asn Lys Ser Ala His Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Val Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Ala Lys Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  140
<211>  28
<212>  PRT
<213>  homo sapiens

<400>  140

Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala 
1               5                   10                  15      


Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu 
            20                  25              


<210>  141
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  141

Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala 
1               5                   10                  15      


Ser Phe Tyr Lys 
            20  


<210>  142
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  142

Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala 
1               5                   10                  15      


Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
            20                  25                  30  


<210>  143
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  143

Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala 
1               5                   10                  15      


Ser Phe Tyr Ser 
            20  


<210>  144
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  144

Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val Pro Met 
1               5                   10                  15      


Lys Val Gln Asn Gln Glu Lys 
            20              


<210>  145
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  145

Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val Pro Met 
1               5                   10                  15      


Lys Val Gln Asn Gln Glu Ser 
            20              


<210>  146
<211>  31
<212>  PRT
<213>  homo sapiens

<400>  146

Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val Pro Met 
1               5                   10                  15      


Lys Val Gln Asn Gln Glu Lys His Leu Gly Ile Glu Phe Ile Glu 
            20                  25                  30      


<210>  147
<211>  63
<212>  PRT
<213>  homo sapiens

<400>  147

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu 
    50                  55                  60              


<210>  148
<211>  55
<212>  PRT
<213>  homo sapiens

<400>  148

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys 
    50                  55  


<210>  149
<211>  65
<212>  PRT
<213>  homo sapiens

<400>  149

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro 
    50                  55                  60                  


Glu 
65  


<210>  150
<211>  55
<212>  PRT
<213>  homo sapiens

<400>  150

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Ser 
    50                  55  


<210>  151
<211>  58
<212>  PRT
<213>  homo sapiens

<400>  151

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
        35                  40                  45              


Val Pro Met Lys Val Gln Asn Gln Glu Lys 
    50                  55              


<210>  152
<211>  58
<212>  PRT
<213>  homo sapiens

<400>  152

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
        35                  40                  45              


Val Pro Met Lys Val Gln Asn Gln Glu Ser 
    50                  55              


<210>  153
<211>  66
<212>  PRT
<213>  homo sapiens

<400>  153

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
        35                  40                  45              


Val Pro Met Lys Val Gln Asn Gln Glu Lys His Leu Gly Ile Glu Phe 
    50                  55                  60                  


Ile Glu 
65      


<210>  154
<211>  52
<212>  PRT
<213>  homo sapiens

<400>  154

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys 
    50          


<210>  155
<211>  52
<212>  PRT
<213>  homo sapiens

<400>  155

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys 
    50          


<210>  156
<211>  91
<212>  PRT
<213>  homo sapiens

<400>  156

Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys 
1               5                   10                  15      


Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Leu Arg Phe Lys 
            20                  25                  30          


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
        35                  40                  45              


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
    50                  55                  60                  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
65                  70                  75                  80  


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
                85                  90      


<210>  157
<211>  126
<212>  PRT
<213>  homo sapiens

<400>  157

Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Glu 
1               5                   10                  15      


Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro 
            20                  25                  30          


Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
        35                  40                  45              


Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Leu 
    50                  55                  60                  


Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys 
65                  70                  75                  80  


Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg 
                85                  90                  95      


Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val 
            100                 105                 110         


Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125     


<210>  158
<211>  63
<212>  PRT
<213>  homo sapiens

<400>  158

Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
1               5                   10                  15      


Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
            20                  25                  30          


Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
        35                  40                  45              


Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
    50                  55                  60              


<210>  159
<211>  1342
<212>  PRT
<213>  homo sapiens

<400>  159

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  160
<211>  1308
<212>  PRT
<213>  homo sapiens

<400>  160

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             

