
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited		
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Quinn, Cheryl L.
      Mendlein, John D.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN
  FRAGMENTS OF LEUCYL-tRNA SYNTHETASES
  

<130> 120161.456PC

<140> PCT                 
<141> 2011-05-16  

<150> US 61/345,531       
<151> 2010-05-17  

<150> US 61/345,532       
<151> 2010-05-17  

<150> US 61/345,533       
<151> 2010-05-17  

<160> 129

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 376
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro
    370                 375     


<210> 13
<211> 1128
<212> DNA
<213> Homo sapiens

<400> 13
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctccca              1128

<210> 14
<211> 11
<212> PRT
<213> Mus musculus

<400> 14
Ser Leu Gly Leu Ser Asp Asp Asp Ile Val Lys
 1               5                  10      


<210> 15
<211> 30
<212> PRT
<213> Mus musculus

<400> 15
Phe Ser Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Val
 1               5                  10                  15      
Gln Asp Leu Lys Thr Ile Gly Leu Lys Val Asp Trp Arg Arg
            20                  25                  30  


<210> 16
<211> 23
<212> PRT
<213> Mus musculus

<400> 16
Ser Phe Ile Thr Thr Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg
 1               5                  10                  15      
Trp Gln Phe Leu Thr Leu Arg
            20              


<210> 17
<211> 27
<212> PRT
<213> Mus musculus

<400> 17
Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr Ser Pro
 1               5                  10                  15      
Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg
            20                  25          


<210> 18
<211> 15
<212> PRT
<213> Mus musculus

<400> 18
Gln Thr Gly Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Val Lys
 1               5                  10                  15  


<210> 19
<211> 82
<212> PRT
<213> Mus musculus

<400> 19
Leu Lys Val Leu Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly
 1               5                  10                  15      
Lys Asn Ile Phe Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe
            20                  25                  30          
Gly Gln Thr Asn Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe
        35                  40                  45              
Glu Thr Ala Asn Gly Asp Ile Phe Ile Cys Thr Gln Arg Ala Ala Arg
    50                  55                  60                  
Asn Met Ser Tyr Gln Gly Phe Thr Lys His Asn Gly Val Val Pro Val
65                  70                  75                  80  
Val Lys
        


<210> 20
<211> 20
<212> PRT
<213> Mus musculus

<400> 20
Glu Leu Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu
 1               5                  10                  15      
Thr Cys Tyr Lys
            20  


<210> 21
<211> 208
<212> PRT
<213> Mus musculus

<400> 21
Ser Leu Gly Leu Ser Asp Asp Asp Ile Val Lys Phe Ser Glu Ala Glu
 1               5                  10                  15      
His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Val Gln Asp Leu Lys Thr
            20                  25                  30          
Ile Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr Asp Val
        35                  40                  45              
Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr Leu Arg
    50                  55                  60                  
Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr Ser Pro
65                  70                  75                  80  
Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly Glu Gly
                85                  90                  95      
Val Gly Pro Gln Glu Tyr Thr Leu Val Lys Leu Lys Val Leu Glu Pro
            100                 105                 110         
Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe Leu Val
        115                 120                 125             
Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn Cys Trp
    130                 135                 140                 
Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Ala Asn Gly Asp
145                 150                 155                 160 
Ile Phe Ile Cys Thr Gln Arg Ala Ala Arg Asn Met Ser Tyr Gln Gly
                165                 170                 175     
Phe Thr Lys His Asn Gly Val Val Pro Val Val Lys Glu Leu Met Gly
            180                 185                 190         
Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Cys Tyr Lys
        195                 200                 205             


<210> 22
<211> 414
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Thr Phe Pro Lys
                405                 410                 


<210> 23
<211> 1245
<212> DNA
<213> Homo sapiens

<400> 23
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa acctttccaa agtga                 1245

<210> 24
<211> 586
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr
                405                 410                 415     
Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile
            420                 425                 430         
Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu
        435                 440                 445             
Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys
    450                 455                 460                 
Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp
465                 470                 475                 480 
Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys
                485                 490                 495     
Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys
            500                 505                 510         
Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp
        515                 520                 525             
Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser
    530                 535                 540                 
Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn
545                 550                 555                 560 
Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr
                565                 570                 575     
Tyr Gly Leu Val Thr Asn Gly Leu Gln Leu
            580                 585     


<210> 25
<211> 1761
<212> DNA
<213> Homo sapiens

<400> 25
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa gccttacgag caaaatatgg aattagagat 1260
gacatggtct tgccatttga gccggtgcca gtcattgaaa tcccaggttt tggaaatctt 1320
tctgctgtaa ccatttgtga tgagttgaaa attcagagcc agaatgaccg ggaaaaactt 1380
gcagaagcaa aggagaagat atatctaaaa ggattttatg agggtatcat gttggtggat 1440
ggatttaaag gacagaaggt tcaagatgta aagaagacta ttcagaaaaa gatgattgac 1500
gctggagatg cacttattta catggaacca gagaaacaag tgatgtccag gtcgtcagat 1560
gaatgtgttg tggctctgtg tgaccagtgg tacttggatt atggagaaga gaattggaag 1620
aaacagacat ctcagtgctt gaagaacctg gaaacattct gtgaggagac caggaggaat 1680
tttgaagcca ccttaggttg gctacaagaa catgcttgct caagaactta tggtctagtg 1740
acaaatggcc tacagctgtg a                                           1761

<210> 26
<211> 707
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr
                405                 410                 415     
Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile
            420                 425                 430         
Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu
        435                 440                 445             
Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys
    450                 455                 460                 
Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp
465                 470                 475                 480 
Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys
                485                 490                 495     
Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys
            500                 505                 510         
Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp
        515                 520                 525             
Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser
    530                 535                 540                 
Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn
545                 550                 555                 560 
Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr
                565                 570                 575     
Tyr Gly Leu Gly Thr His Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu
            580                 585                 590         
Ser Leu Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala His
        595                 600                 605             
Leu Leu Gln Gly Gly Asn Leu His Gly Gln Ala Glu Ser Pro Leu Gly
    610                 615                 620                 
Ile Arg Pro Gln Gln Met Thr Lys Glu Val Trp Asp Tyr Val Phe Phe
625                 630                 635                 640 
Lys Glu Ala Pro Phe Pro Lys Thr Gln Ile Ala Lys Glu Lys Leu Asp
                645                 650                 655     
Gln Leu Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu Arg Val
            660                 665                 670         
Ser Gly Lys Asp Leu Val Pro Asn His Leu Ser Tyr Tyr Leu Tyr Asn
        675                 680                 685             
His Val Ala Met Trp Pro Glu Gln Arg Cys Gln Asn Pro Gln Ala Thr
    690                 695                 700                 
Ser Ser Leu
705         


<210> 27
<211> 2124
<212> DNA
<213> Homo sapiens

<400> 27
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa gccttacgag caaaatatgg aattagagat 1260
gacatggtct tgccatttga gccggtgcca gtcattgaaa tcccaggttt tggaaatctt 1320
tctgctgtaa ccatttgtga tgagttgaaa attcagagcc agaatgaccg ggaaaaactt 1380
gcagaagcaa aggagaagat atatctaaaa ggattttatg agggtatcat gttggtggat 1440
ggatttaaag gacagaaggt tcaagatgta aagaagacta ttcagaaaaa gatgattgac 1500
gctggagatg cacttattta catggaacca gagaaacaag tgatgtccag gtcgtcagat 1560
gaatgtgttg tggctctgtg tgaccagtgg tacttggatt atggagaaga gaattggaag 1620
aaacagacat ctcagtgctt gaagaacctg gaaacattct gtgaggagac caggaggaat 1680
tttgaagcca ccttaggttg gctacaagaa catgcttgct caagaactta tggtctaggc 1740
actcacctgc cttgggatga gcagtggctg attgaatcac tttctgactc cactatttac 1800
atggcatttt acacagttgc acacctattg caggggggta acttgcatgg acaggcagag 1860
tctccgctgg gcattagacc gcaacagatg accaaggaag tttgggatta tgttttcttc 1920
aaggaggctc catttcctaa gactcagatt gcaaaggaaa aattagatca gttaaagcag 1980
gagtttgaat tctggtatcc tgttgatctt cgcgtctctg gcaaggatct tgttccaaat 2040
catctttcat attaccttta taatcatgtg gctatgtggc cggaacaaag atgtcaaaat 2100
ccacaggcaa cttcctcact ttga                                        2124

<210> 28
<211> 50
<212> DNA
<213> Homo sapiens

<400> 28
cctcagagac ttgaagaaaa agcaaacctt tccaaagtga aactgatgag            50

<210> 29
<211> 12
<212> PRT
<213> Homo sapiens

<400> 29
Leu Arg Asp Leu Lys Lys Lys Gln Thr Phe Pro Lys
 1               5                  10          


<210> 30
<211> 50
<212> DNA
<213> Homo sapiens

<400> 30
gcttgctcaa gaacttatgg tctagtgaca aatggcctac agctgtgaga            50

<210> 31
<211> 15
<212> PRT
<213> Homo sapiens

<400> 31
Ala Cys Ser Arg Thr Tyr Gly Leu Val Thr Asn Gly Leu Gln Leu
 1               5                  10                  15  


<210> 32
<211> 50
<212> DNA
<213> Homo sapiens

<400> 32
atgtggctat gtggccggaa caaagatgtc aaaatccaca ggcaacttcc            50

<210> 33
<211> 16
<212> PRT
<213> Homo sapiens

<400> 33
Val Ala Met Trp Pro Glu Gln Arg Cys Gln Asn Pro Gln Ala Thr Ser
 1               5                  10                  15      


<210> 34
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 34
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe
            20                  25                  30          
Leu Lys Lys Ile Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg
        35                  40                  45              
Val Phe Glu Val Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly
    50                  55                  60                  
Lys Tyr Phe Val Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His
65                  70                  75                  80  
Leu Gly His Thr Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr
                85                  90                  95      
Gln Arg Leu Lys Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys
            100                 105                 110         
Thr Gly Met Pro Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile
        115                 120                 125             
Glu Leu Tyr Gly Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu
    130                 135                 140                 
Glu Glu Thr Ser Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala
145                 150                 155                 160 
Lys Gly Lys Lys Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr
                165                 170                 175     
Gln Trp Gly Ile Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val
            180                 185                 190         
Lys Phe Ser Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala
        195                 200                 205             
Ile Gln Asp Leu Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser
    210                 215                 220                 
Phe Ile Thr Thr Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp
225                 230                 235                 240 
Gln Phe Leu Thr Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg
                245                 250                 255     
Tyr Thr Ile Tyr Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp
            260                 265                 270         
Arg Gln Thr Gly Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys
        275                 280                 285             
Leu Lys Val Leu Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly
    290                 295                 300                 
Lys Asn Ile Phe Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe
305                 310                 315                 320 
Gly Gln Thr Asn Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe
                325                 330                 335     
Glu Thr Val Asn Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg
            340                 345                 350         
Asn Met Ser Tyr Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val
        355                 360                 365             
Val Lys Glu Leu Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala
    370                 375                 380                 
Pro Leu Thr Ser Tyr Lys Val Ile Tyr Val Leu Pro
385                 390                 395     


<210> 35
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 35
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Gly Lys Pro Ile Pro Asn Pro Leu
    370                 375                 380                 
Leu Gly Leu Asp Ser Thr His His His His His His
385                 390                 395     


<210> 36
<211> 434
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 36
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe
            20                  25                  30          
Leu Lys Lys Ile Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg
        35                  40                  45              
Val Phe Glu Val Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly
    50                  55                  60                  
Lys Tyr Phe Val Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His
65                  70                  75                  80  
Leu Gly His Thr Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr
                85                  90                  95      
Gln Arg Leu Lys Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys
            100                 105                 110         
Thr Gly Met Pro Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile
        115                 120                 125             
Glu Leu Tyr Gly Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu
    130                 135                 140                 
Glu Glu Thr Ser Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala
145                 150                 155                 160 
Lys Gly Lys Lys Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr
                165                 170                 175     
Gln Trp Gly Ile Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val
            180                 185                 190         
Lys Phe Ser Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala
        195                 200                 205             
Ile Gln Asp Leu Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser
    210                 215                 220                 
Phe Ile Thr Thr Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp
225                 230                 235                 240 
Gln Phe Leu Thr Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg
                245                 250                 255     
Tyr Thr Ile Tyr Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp
            260                 265                 270         
Arg Gln Thr Gly Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys
        275                 280                 285             
Leu Lys Val Leu Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly
    290                 295                 300                 
Lys Asn Ile Phe Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe
305                 310                 315                 320 
Gly Gln Thr Asn Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe
                325                 330                 335     
Glu Thr Val Asn Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg
            340                 345                 350         
Asn Met Ser Tyr Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val
        355                 360                 365             
Val Lys Glu Leu Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala
    370                 375                 380                 
Pro Leu Thr Ser Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile
385                 390                 395                 400 
Lys Glu Asp Lys Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser
                405                 410                 415     
Pro Asp Asp Ile Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Thr Phe
            420                 425                 430         
Pro Lys
        


<210> 37
<211> 434
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 37
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Thr Phe Pro Lys Gly Lys
                405                 410                 415     
Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His
            420                 425                 430         
His His
        


<210> 38
<211> 606
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 38
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe
            20                  25                  30          
Leu Lys Lys Ile Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg
        35                  40                  45              
Val Phe Glu Val Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly
    50                  55                  60                  
Lys Tyr Phe Val Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His
65                  70                  75                  80  
Leu Gly His Thr Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr
                85                  90                  95      
Gln Arg Leu Lys Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys
            100                 105                 110         
Thr Gly Met Pro Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile
        115                 120                 125             
Glu Leu Tyr Gly Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu
    130                 135                 140                 
Glu Glu Thr Ser Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala
145                 150                 155                 160 
Lys Gly Lys Lys Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr
                165                 170                 175     
Gln Trp Gly Ile Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val
            180                 185                 190         
Lys Phe Ser Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala
        195                 200                 205             
Ile Gln Asp Leu Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser
    210                 215                 220                 
Phe Ile Thr Thr Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp
225                 230                 235                 240 
Gln Phe Leu Thr Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg
                245                 250                 255     
Tyr Thr Ile Tyr Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp
            260                 265                 270         
Arg Gln Thr Gly Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys
        275                 280                 285             
Leu Lys Val Leu Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly
    290                 295                 300                 
Lys Asn Ile Phe Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe
305                 310                 315                 320 
Gly Gln Thr Asn Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe
                325                 330                 335     
Glu Thr Val Asn Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg
            340                 345                 350         
Asn Met Ser Tyr Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val
        355                 360                 365             
Val Lys Glu Leu Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala
    370                 375                 380                 
Pro Leu Thr Ser Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile
385                 390                 395                 400 
Lys Glu Asp Lys Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser
                405                 410                 415     
Pro Asp Asp Ile Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu
            420                 425                 430         
Arg Ala Lys Tyr Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro
        435                 440                 445             
Val Pro Val Ile Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr
    450                 455                 460                 
Ile Cys Asp Glu Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu
465                 470                 475                 480 
Ala Glu Ala Lys Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile
                485                 490                 495     
Met Leu Val Asp Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys
            500                 505                 510         
Thr Ile Gln Lys Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met
        515                 520                 525             
Glu Pro Glu Lys Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val
    530                 535                 540                 
Ala Leu Cys Asp Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys
545                 550                 555                 560 
Lys Gln Thr Ser Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu
                565                 570                 575     
Thr Arg Arg Asn Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala
            580                 585                 590         
Cys Ser Arg Thr Tyr Gly Leu Val Thr Asn Gly Leu Gln Leu
        595                 600                 605     


<210> 39
<211> 606
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 39
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr
                405                 410                 415     
Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile
            420                 425                 430         
Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu
        435                 440                 445             
Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys
    450                 455                 460                 
Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp
465                 470                 475                 480 
Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys
                485                 490                 495     
Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys
            500                 505                 510         
Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp
        515                 520                 525             
Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser
    530                 535                 540                 
Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn
545                 550                 555                 560 
Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr
                565                 570                 575     
Tyr Gly Leu Val Thr Asn Gly Leu Gln Leu Gly Lys Pro Ile Pro Asn
            580                 585                 590         
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
        595                 600                 605     


<210> 40
<211> 1137
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA synthetase
      polynucleotide

<400> 40
gcagaacgca aaggcaccgc aaaagtagac ttcctgaaaa agattgagaa agaaatccag 60
cagaagtggg acacggagcg cgtctttgag gtcaatgctt cgaacctgga gaaacagacc 120
tctaaaggca agtacttcgt tacctttccg tatccgtaca tgaatggtcg tttgcacctg 180
ggccatacct ttagcctgtc taagtgtgag ttcgccgttg gttaccaacg cttgaaaggt 240
aagtgctgtc tgtttccgtt cggtctgcac tgcacgggta tgccgatcaa agcatgcgcg 300
gacaagctga agcgtgaaat cgagctgtat ggctgcccac cagattttcc ggatgaagaa 360
gaagaagaag aagaaaccag cgtgaaaacg gaggatatta tcatcaaaga taaggcaaaa 420
ggtaagaaga gcaaggcagc ggccaaagcg ggtagcagca aatatcaatg gggcattatg 480
aaaagcctgg gtctgtccga tgaagagatt gtgaagttca gcgaggctga gcattggctg 540
gactacttcc ctccgctggc cattcaagac ttgaagcgta tgggtctgaa ggttgattgg 600
cgtcgtagct tcattacgac cgacgtgaat ccgtactatg atagctttgt ccgttggcag 660
tttctgaccc tgcgtgagcg caataaaatt aaattcggta agcgctacac catttacagc 720
ccgaaagacg gccagccgtg tatggaccac gaccgtcaaa ctggtgaggg cgttggcccg 780
caggagtata ccctgctgaa gttgaaggtg ctggagccat acccgagcaa attgagcggt 840
ctgaaaggca agaacatctt tctggttgcg gcgacgctgc gtcctgaaac catgttcggt 900
caaaccaatt gttgggtccg cccggatatg aaatatatcg gctttgaaac tgtgaacggt 960
gacattttca tctgcaccca gaaagcagca cgtaacatga gctatcaagg tttcaccaag 1020
gacaacggtg tggtgccggt tgtcaaagag ctgatgggcg aagaaattct gggcgcgagc 1080
ctgtccgcgc cgctgacgtc gtacaaagtt atctacgtcc tgccgtaatg actcgag    1137

<210> 41
<211> 1251
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA synthetase
      polynucleotide

<400> 41
gcagaacgca aaggcaccgc aaaagtagac ttcctgaaaa agattgagaa agaaattcag 60
cagaaatggg acaccgagcg tgtgttcgag gtcaacgcga gcaatctgga gaaacagacg 120
agcaaaggta agtattttgt taccttccca tacccgtaca tgaacggtcg tctgcatctg 180
ggtcatacgt tctctctgtc caaatgcgag ttcgcagtgg gttatcagcg tctgaagggt 240
aagtgctgtc tgtttccgtt cggtctgcac tgtaccggca tgccgattaa ggcgtgcgcg 300
gataagctga aacgtgagat cgagctgtat ggttgtccgc cggactttcc ggacgaagaa 360
gaagaagaag aagagactag cgtgaaaacg gaggatatca tcattaagga caaggcaaag 420
ggtaagaaaa gcaaagcagc agcgaaagct ggttctagca aatatcagtg gggtattatg 480
aaaagcttgg gcctgagcga cgaagagatt gtgaagttta gcgaggctga gcactggctg 540
gattatttcc cgccgctggc gattcaagat ctgaaacgta tgggcttgaa ggttgattgg 600
cgccgttcgt tcatcaccac cgacgtgaac ccgtactacg acagcttcgt tcgttggcaa 660
tttctgaccc tgcgcgaacg caacaagatc aagttcggta aacgctacac catttattcc 720
ccgaaagatg gccaaccatg catggatcac gatcgtcaga ccggcgaggg tgtcggcccg 780
caagagtata ccctgctgaa gttgaaagtt ctggaaccgt acccgagcaa gctgagcggc 840
ttgaaaggta agaacatctt tctggtcgcc gccacgctgc gcccagaaac gatgttcggc 900
cagacgaatt gttgggttcg tccggacatg aaatacattg gttttgagac tgtcaatggt 960
gacatcttta tctgcaccca aaaggcagcg cgcaatatgt cctaccaggg ctttaccaaa 1020
gataatggtg tggtgcctgt ggtcaaagaa ctgatgggcg aagaaattct gggtgcgagc 1080
ctgagcgccc ctttgacgtc gtacaaggtc atctacgttc tgccgatgct gaccattaaa 1140
gaggacaagg gtactggcgt tgttacgagc gtcccgagcg acagcccgga cgacatcgcg 1200
gccctgcgtg atctgaagaa gaaacaaacc ttcccgaagt aatgactcga g          1251

<210> 42
<211> 1767
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA synthetase
      polynucleotide

<400> 42
gcagaacgca aaggcaccgc aaaagtagac ttcctgaaaa agattgagaa agaaatccag 60
caaaagtggg ataccgagcg cgtctttgag gtcaatgcga gcaatctgga gaaacagacc 120
tccaaaggta aatacttcgt tacctttccg tatccgtaca tgaacggtcg cctgcacctg 180
ggtcatacct tcagcctgag caaatgcgag tttgccgtgg gttaccagcg tctgaagggc 240
aagtgctgtc tgttcccatt tggcctgcat tgcacgggta tgccgattaa agcgtgtgct 300
gataagctga agcgtgagat tgagctgtac ggttgtcctc cggattttcc ggatgaagaa 360
gaagaagaag aagaaacgtc ggtgaaaacg gaagatatta tcattaaaga caaggctaag 420
ggcaagaagt cgaaggcggc tgcaaaagca ggcagcagca agtatcaatg gggtattatg 480
aagagcttgg gtctgagcga cgaagagatc gtgaagttct ccgaggcgga gcactggctg 540
gactactttc cgccgttggc catccaagat ttgaaacgca tgggtctgaa agtggattgg 600
cgtcgcagct ttatcaccac ggacgtcaac ccgtactatg actcttttgt ccgttggcag 660
ttcctgaccc tgcgcgagcg taataaaatt aaatttggca agcgttacac tatttattct 720
ccaaaagatg gccagccgtg tatggaccac gaccgtcaga cgggtgaggg tgtcggtccg 780
caggagtata ccctgctgaa actgaaagtt ctggagccat acccgtctaa gctgagcggc 840
ctgaaaggta agaatatttt cttggtggct gcgaccctgc gtccggaaac catgttcggt 900
cagacgaact gctgggttcg tccggacatg aaatatatcg gcttcgagac tgttaacggt 960
gacatcttca tctgcacgca gaaagcggca cgtaacatga gctaccaagg cttcaccaag 1020
gataatggtg ttgtgcctgt ggtgaaagaa ctgatgggtg aagagatcct gggcgccagc 1080
ctgtccgcgc cgctgacgtc ctacaaggtg atctacgttc tgccgatgct gacgatcaaa 1140
gaagataagg gcaccggcgt tgtcactagc gtgccgagcg atagcccgga tgatattgca 1200
gcgttgcgtg acctgaagaa gaaacaggcg ctgcgcgcca agtacggtat ccgtgacgac 1260
atggtgttgc cgtttgaacc ggtcccggtt atcgagatcc cgggtttcgg taacctgagc 1320
gcggtcacca tttgcgacga gttgaaaatt cagtctcaaa acgatcgcga gaagctggca 1380
gaggccaaag agaaaattta cttgaagggt ttctacgaag gtatcatgct ggtcgacggc 1440
ttcaagggtc agaaagttca agacgtcaag aaaaccattc agaagaaaat gatcgacgcg 1500
ggcgatgcac tgatttatat ggagccggag aaacaagtta tgagccgcag cagcgacgag 1560
tgcgttgttg cactgtgtga ccagtggtat ctggactatg gcgaagaaaa ttggaagaaa 1620
caaaccagcc aatgcctgaa gaacctggag actttctgtg aagaaacgcg tcgtaacttt 1680
gaggcgaccc tgggttggct gcaagaacac gcgtgcagcc gtacctatgg cctggtgacc 1740
aatggtctgc aactgtaatg actcgag                                     1767

<210> 43
<211> 640
<212> PRT
<213> Homo sapiens

<400> 43
Glu Asn Trp Lys Lys Gln Thr Ser Gln Cys Leu Lys Asn Leu Glu Thr
 1               5                  10                  15      
Phe Cys Glu Glu Thr Arg Arg Asn Phe Glu Ala Thr Leu Gly Trp Leu
            20                  25                  30          
Gln Glu His Ala Cys Ser Arg Thr Tyr Gly Leu Gly Thr His Leu Pro
        35                  40                  45              
Trp Asp Glu Gln Trp Leu Ile Glu Ser Leu Ser Asp Ser Thr Ile Tyr
    50                  55                  60                  
Met Ala Phe Tyr Thr Val Ala His Leu Leu Gln Gly Gly Asn Leu His
65                  70                  75                  80  
Gly Gln Ala Glu Ser Pro Leu Gly Ile Arg Pro Gln Gln Met Thr Lys
                85                  90                  95      
Glu Val Trp Asp Tyr Val Phe Phe Lys Glu Ala Pro Phe Pro Lys Thr
            100                 105                 110         
Gln Ile Ala Lys Glu Lys Leu Asp Gln Leu Lys Gln Glu Phe Glu Phe
        115                 120                 125             
Trp Tyr Pro Val Asp Leu Arg Val Ser Gly Lys Asp Leu Val Pro Asn
    130                 135                 140                 
His Leu Ser Tyr Tyr Leu Tyr Asn His Val Ala Met Trp Pro Glu Gln
145                 150                 155                 160 
Ser Asp Lys Trp Pro Thr Ala Val Arg Ala Asn Gly His Leu Leu Leu
                165                 170                 175     
Asn Ser Glu Lys Met Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu Thr
            180                 185                 190         
Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu Ala
        195                 200                 205             
Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met Ala
    210                 215                 220                 
Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys Glu
225                 230                 235                 240 
Met Val Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr Phe
                245                 250                 255     
Asn Asp Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys Thr
            260                 265                 270         
Asp Gln Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr Gly
        275                 280                 285             
Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala Val
    290                 295                 300                 
Glu Gly Met His Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln Thr
305                 310                 315                 320 
Leu Leu Leu Ala Pro Phe Cys Pro His Leu Cys Glu His Ile Trp Thr
                325                 330                 335     
Leu Leu Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val Ala
            340                 345                 350         
Gly Pro Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu
        355                 360                 365             
Val Thr His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala
    370                 375                 380                 
Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys
385                 390                 395                 400 
Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu
                405                 410                 415     
Ser Val Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp
            420                 425                 430         
Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys
        435                 440                 445             
Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu
    450                 455                 460                 
Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu
465                 470                 475                 480 
Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu
                485                 490                 495     
Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile
            500                 505                 510         
Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu
        515                 520                 525             
Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln Pro Ser Asn Gly His
    530                 535                 540                 
Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp Ser Ile
545                 550                 555                 560 
Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile Lys Asp Leu Ser Lys
                565                 570                 575     
Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val
            580                 585                 590         
Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His
        595                 600                 605             
Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu
    610                 615                 620                 
Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His
625                 630                 635                 640 


<210> 44
<211> 1923
<212> DNA
<213> Homo sapiens

<400> 44
gagaattgga agaaacagac atctcagtgc ttgaagaacc tggaaacatt ctgtgaggag 60
accaggagga attttgaagc caccttaggt tggctacaag aacatgcttg ctcaagaact 120
tatggtctag gcactcacct gccttgggat gagcagtggc tgattgaatc actttctgac 180
tccactattt acatggcatt ttacacagtt gcacacctat tgcagggggg taacttgcat 240
ggacaggcag agtctccgct gggcattaga ccgcaacaga tgaccaagga agtttgggat 300
tatgttttct tcaaggaggc tccatttcct aagactcaga ttgcaaagga aaaattagat 360
cagttaaagc aggagtttga attctggtat cctgttgatc ttcgcgtctc tggcaaggat 420
cttgttccaa atcatctttc atattacctt tataatcatg tggctatgtg gccggaacaa 480
agtgacaaat ggcctacagc tgtgagagca aatggacatc tcctcctgaa ctctgagaag 540
atgtcaaaat ccacaggcaa cttcctcact ttgacccaag ctattgacaa attttcagca 600
gatggaatgc gtttggctct ggctgatgct ggtgacactg tagaagatgc caactttgtg 660
gaagccatgg cagatgcagg tattctccgt ctgtacacct gggtagagtg ggtgaaagaa 720
atggttgcca actgggacag cctaagaagt ggtcctgcca gcactttcaa tgatagagtt 780
tttgccagtg aattgaatgc aggaattata aaaacagatc aaaactatga aaagatgatg 840
tttaaagaag ctttgaaaac agggtttttt gagtttcagg ccgcaaaaga taagtaccgt 900
gaattggctg tggaagggat gcacagagaa cttgtgttcc ggtttattga agttcagaca 960
cttctcctcg ctccattctg tccacatttg tgtgagcaca tctggacact cctgggaaag 1020
cctgactcaa ttatgaatgc ttcatggcct gtggcaggtc ctgttaatga agttttaata 1080
cactcctcac agtatcttat ggaagtaaca catgacctta gactacgact caagaactat 1140
atgatgccag ctaaagggaa gaagactgac aaacaacccc tgcagaagcc ctcacattgc 1200
accatctatg tggcaaagaa ctatccacct tggcaacata ccaccctgtc tgttctacgt 1260
aaacactttg aggccaataa cggaaaactg cctgacaaca aagtcattgc tagtgaacta 1320
ggcagtatgc cagaactgaa gaaatacatg aagaaagtca tgccatttgt tgccatgatt 1380
aaggaaaatc tggagaagat ggggcctcgt attctggatt tgcaattaga atttgatgaa 1440
aaggctgtgc ttatggagaa tatagtctat ctgactaatt cgcttgagct agaacacata 1500
gaagtcaagt ttgcctccga agcagaagat aaaatcaggg aagactgctg tcctgggaaa 1560
ccacttaatg tttttagaat agaacctggt gtgtccgttt ctctggtgaa tccccagcca 1620
tccaatggcc acttctcaac caaaattgaa atcaggcaag gagataactg tgattccata 1680
atcaggcgtt taatgaaaat gaatcgagga attaaagacc tttccaaagt gaaactgatg 1740
agatttgatg atccactgtt ggggcctcga cgagttcctg tcctgggaaa ggagtacacc 1800
gagaagaccc ccatttctga gcatgctgtt ttcaatgtgg acctcatgag caagaaaatt 1860
catctgactg agaatgggat aagggtggat attggcgata caataatcta tctggttcat 1920
taa                                                               1923

<210> 45
<211> 16
<212> PRT
<213> Mus musculus

<400> 45
Asn Phe Glu Ala Ser Leu Asp Trp Leu Gln Glu His Ala Cys Ser Arg
 1               5                  10                  15      


<210> 46
<211> 79
<212> PRT
<213> Mus musculus

<400> 46
Thr Tyr Gly Leu Gly Thr Arg Leu Pro Trp Asp Glu Gln Trp Leu Ile
 1               5                  10                  15      
Glu Ser Leu Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala
            20                  25                  30          
His Leu Leu Gln Gly Gly Asp Leu Asn Gly Gln Ala Glu Ser Pro Leu
        35                  40                  45              
Gly Ile Arg Pro Gln Gln Met Thr Lys Asp Val Trp Asp Tyr Val Phe
    50                  55                  60                  
Phe Lys Asp Ala Pro Phe Pro Lys Thr Gln Ile Pro Lys Glu Lys
65                  70                  75                  


<210> 47
<211> 17
<212> PRT
<213> Mus musculus

<400> 47
Leu Asp Gln Leu Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu
 1               5                  10                  15      
Arg
    


<210> 48
<211> 48
<212> PRT
<213> Mus musculus

<400> 48
Ala Ser Gly Lys Asp Leu Ile Pro Asn His Leu Ser Tyr Tyr Ile Tyr
 1               5                  10                  15      
Asn His Val Ala Met Trp Pro Glu Gln Ser Asp Lys Trp Pro Val Ser
            20                  25                  30          
Val Arg Ala Asn Gly His Leu Leu Leu Asn Ser Glu Lys Met Ser Lys
        35                  40                  45              


<210> 49
<211> 14
<212> PRT
<213> Mus musculus

<400> 49
Ser Thr Gly Asn Phe Leu Thr Leu Ser Gln Ala Val Asp Lys
 1               5                  10                  


<210> 50
<211> 7
<212> PRT
<213> Mus musculus

<400> 50
Phe Ser Ala Asp Gly Met Arg
 1               5          


<210> 51
<211> 26
<212> PRT
<213> Mus musculus

<400> 51
Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val
 1               5                  10                  15      
Glu Ala Met Ala Asp Ala Gly Ile Leu Arg
            20                  25      


<210> 52
<211> 176
<212> PRT
<213> Mus musculus

<400> 52
Leu Tyr Thr Trp Val Glu Trp Val Lys Glu Met Leu Ala Ser Cys Ser
 1               5                  10                  15      
Ser Leu Arg Ser Gly Pro Ala Asp Ser Phe Asn Asp Arg Val Phe Ala
            20                  25                  30          
Ser Glu Met Asn Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr Glu Lys
        35                  40                  45              
Met Met Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe Gln Ala
    50                  55                  60                  
Ala Lys Asp Lys Tyr Arg Glu Leu Ala Thr Glu Gly Met His Arg Glu
65                  70                  75                  80  
Leu Val Phe Arg Phe Ile Glu Val Gln Thr Ile Leu Leu Thr Pro Phe
                85                  90                  95      
Cys Pro His Leu Cys Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp
            100                 105                 110         
Ser Ile Met His Ala Ser Trp Pro Val Ala Gly Pro Val Asp Glu Ser
        115                 120                 125             
Leu Ile Arg Ser Ser Gln Tyr Leu Met Glu Val Ala His Asp Leu Arg
    130                 135                 140                 
Leu Arg Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp
145                 150                 155                 160 
Lys Gln Pro Ala Gln Arg Pro Ser His Cys Thr Ile Tyr Val Ala Lys
                165                 170                 175     


<210> 53
<211> 14
<212> PRT
<213> Mus musculus

<400> 53
Asn Tyr Pro Val Trp Gln His Ile Thr Leu Thr Thr Leu Arg
 1               5                  10                  


<210> 54
<211> 14
<212> PRT
<213> Mus musculus

<400> 54
Ser His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys
 1               5                  10                  


<210> 55
<211> 14
<212> PRT
<213> Mus musculus

<400> 55
Val Ile Ala Ser Glu Leu Gly Ser Leu Pro Glu Leu Lys Lys
 1               5                  10                  


<210> 56
<211> 45
<212> PRT
<213> Mus musculus

<400> 56
Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Met
 1               5                  10                  15      
Glu Lys Lys Gly Pro Arg Val Leu Asp Leu Glu Leu Glu Phe Asp Glu
            20                  25                  30          
Gln Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn
        35                  40                  45  


<210> 57
<211> 10
<212> PRT
<213> Mus musculus

<400> 57
Ser Leu Glu Leu Glu His Ile Glu Val Lys
 1               5                  10  


<210> 58
<211> 23
<212> PRT
<213> Mus musculus

<400> 58
Phe Ala Ser Glu Ala Glu Asp Lys Val Arg Glu Glu Cys Cys Pro Gly
 1               5                  10                  15      
Lys Pro Leu Asn Val Phe Arg
            20              


<210> 59
<211> 22
<212> PRT
<213> Mus musculus

<400> 59
Thr Glu Pro Gly Val Pro Val Ser Leu Val Asn Pro Gln Pro Ser Ser
 1               5                  10                  15      
Gly His Phe Ser Thr Lys
            20          


<210> 60
<211> 525
<212> PRT
<213> Mus musculus

<400> 60
Asn Phe Glu Ala Ser Leu Asp Trp Leu Gln Glu His Ala Cys Ser Arg
 1               5                  10                  15      
Thr Tyr Gly Leu Gly Thr Arg Leu Pro Trp Asp Glu Gln Trp Leu Ile
            20                  25                  30          
Glu Ser Leu Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala
        35                  40                  45              
His Leu Leu Gln Gly Gly Asp Leu Asn Gly Gln Ala Glu Ser Pro Leu
    50                  55                  60                  
Gly Ile Arg Pro Gln Gln Met Thr Lys Asp Val Trp Asp Tyr Val Phe
65                  70                  75                  80  
Phe Lys Asp Ala Pro Phe Pro Lys Thr Gln Ile Pro Lys Glu Lys Leu
                85                  90                  95      
Asp Gln Leu Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu Arg
            100                 105                 110         
Ala Ser Gly Lys Asp Leu Ile Pro Asn His Leu Ser Tyr Tyr Ile Tyr
        115                 120                 125             
Asn His Val Ala Met Trp Pro Glu Gln Ser Asp Lys Trp Pro Val Ser
    130                 135                 140                 
Val Arg Ala Asn Gly His Leu Leu Leu Asn Ser Glu Lys Met Ser Lys
145                 150                 155                 160 
Ser Thr Gly Asn Phe Leu Thr Leu Ser Gln Ala Val Asp Lys Phe Ser
                165                 170                 175     
Ala Asp Gly Met Arg Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu
            180                 185                 190         
Asp Ala Asn Phe Val Glu Ala Met Ala Asp Ala Gly Ile Leu Arg Leu
        195                 200                 205             
Tyr Thr Trp Val Glu Trp Val Lys Glu Met Leu Ala Ser Cys Ser Ser
    210                 215                 220                 
Leu Arg Ser Gly Pro Ala Asp Ser Phe Asn Asp Arg Val Phe Ala Ser
225                 230                 235                 240 
Glu Met Asn Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr Glu Lys Met
                245                 250                 255     
Met Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe Gln Ala Ala
            260                 265                 270         
Lys Asp Lys Tyr Arg Glu Leu Ala Thr Glu Gly Met His Arg Glu Leu
        275                 280                 285             
Val Phe Arg Phe Ile Glu Val Gln Thr Ile Leu Leu Thr Pro Phe Cys
    290                 295                 300                 
Pro His Leu Cys Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser
305                 310                 315                 320 
Ile Met His Ala Ser Trp Pro Val Ala Gly Pro Val Asp Glu Ser Leu
                325                 330                 335     
Ile Arg Ser Ser Gln Tyr Leu Met Glu Val Ala His Asp Leu Arg Leu
            340                 345                 350         
Arg Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys
        355                 360                 365             
Gln Pro Ala Gln Arg Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn
    370                 375                 380                 
Tyr Pro Val Trp Gln His Ile Thr Leu Thr Thr Leu Arg Ser His Phe
385                 390                 395                 400 
Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu
                405                 410                 415     
Leu Gly Ser Leu Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro
            420                 425                 430         
Phe Val Ala Met Ile Lys Glu Asn Met Glu Lys Lys Gly Pro Arg Val
        435                 440                 445             
Leu Asp Leu Glu Leu Glu Phe Asp Glu Gln Ala Val Leu Met Glu Asn
    450                 455                 460                 
Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys
465                 470                 475                 480 
Phe Ala Ser Glu Ala Glu Asp Lys Val Arg Glu Glu Cys Cys Pro Gly
                485                 490                 495     
Lys Pro Leu Asn Val Phe Arg Thr Glu Pro Gly Val Pro Val Ser Leu
            500                 505                 510         
Val Asn Pro Gln Pro Ser Ser Gly His Phe Ser Thr Lys
        515                 520                 525 


<210> 61
<211> 1122
<212> PRT
<213> Homo sapiens

<400> 61
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Val Asp Trp Arg Arg Ser Phe Ile Thr Thr Asp Val Asn Pro Tyr Tyr
145                 150                 155                 160 
Asp Ser Phe Val Arg Trp Gln Phe Leu Thr Leu Arg Glu Arg Asn Lys
                165                 170                 175     
Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr Ser Pro Lys Asp Gly Gln
            180                 185                 190         
Pro Cys Met Asp His Asp Arg Gln Thr Gly Glu Gly Val Gly Pro Gln
        195                 200                 205             
Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu Glu Pro Tyr Pro Ser Lys
    210                 215                 220                 
Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe Leu Val Ala Ala Thr Leu
225                 230                 235                 240 
Arg Pro Glu Thr Met Phe Gly Gln Thr Asn Cys Trp Val Arg Pro Asp
                245                 250                 255     
Met Lys Tyr Ile Gly Phe Glu Thr Val Asn Gly Asp Ile Phe Ile Cys
            260                 265                 270         
Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr Gln Gly Phe Thr Lys Asp
        275                 280                 285             
Asn Gly Val Val Pro Val Val Lys Glu Leu Met Gly Glu Glu Ile Leu
    290                 295                 300                 
Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser Tyr Lys Val Ile Tyr Val
305                 310                 315                 320 
Leu Pro Met Leu Thr Ile Lys Glu Asp Lys Gly Thr Gly Val Val Thr
                325                 330                 335     
Ser Val Pro Ser Asp Ser Pro Asp Asp Ile Ala Ala Leu Arg Asp Leu
            340                 345                 350         
Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr Gly Ile Arg Asp Asp Met
        355                 360                 365             
Val Leu Pro Phe Glu Pro Val Pro Val Ile Glu Ile Pro Gly Phe Gly
    370                 375                 380                 
Asn Leu Ser Ala Val Thr Ile Cys Asp Glu Leu Lys Ile Gln Ser Gln
385                 390                 395                 400 
Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys Glu Lys Ile Tyr Leu Lys
                405                 410                 415     
Gly Phe Tyr Glu Gly Ile Met Leu Val Asp Gly Phe Lys Gly Gln Lys
            420                 425                 430         
Val Gln Asp Val Lys Lys Thr Ile Gln Lys Lys Met Ile Asp Ala Gly
        435                 440                 445             
Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys Gln Val Met Ser Arg Ser
    450                 455                 460                 
Ser Asp Glu Cys Val Val Ala Leu Cys Asp Gln Trp Tyr Leu Asp Tyr
465                 470                 475                 480 
Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser Gln Cys Leu Lys Asn Leu
                485                 490                 495     
Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn Phe Glu Ala Thr Leu Gly
            500                 505                 510         
Trp Leu Gln Glu His Ala Cys Ser Arg Thr Tyr Gly Leu Gly Thr His
        515                 520                 525             
Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu Ser Leu Ser Asp Ser Thr
    530                 535                 540                 
Ile Tyr Met Ala Phe Tyr Thr Val Ala His Leu Leu Gln Gly Gly Asn
545                 550                 555                 560 
Leu His Gly Gln Ala Glu Ser Pro Leu Gly Ile Arg Pro Gln Gln Met
                565                 570                 575     
Thr Lys Glu Val Trp Asp Tyr Val Phe Phe Lys Glu Ala Pro Phe Pro
            580                 585                 590         
Lys Thr Gln Ile Ala Lys Glu Lys Leu Asp Gln Leu Lys Gln Glu Phe
        595                 600                 605             
Glu Phe Trp Tyr Pro Val Asp Leu Arg Val Ser Gly Lys Asp Leu Val
    610                 615                 620                 
Pro Asn His Leu Ser Tyr Tyr Leu Tyr Asn His Val Ala Met Trp Pro
625                 630                 635                 640 
Glu Gln Ser Asp Lys Trp Pro Thr Ala Val Arg Ala Asn Gly His Leu
                645                 650                 655     
Leu Leu Asn Ser Glu Lys Met Ser Lys Ser Thr Gly Asn Phe Leu Thr
            660                 665                 670         
Leu Thr Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu Ala
        675                 680                 685             
Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu Ala
    690                 695                 700                 
Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp Val
705                 710                 715                 720 
Lys Glu Met Val Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser
                725                 730                 735     
Thr Phe Asn Asp Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile
            740                 745                 750         
Lys Thr Asp Gln Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu Lys
        755                 760                 765             
Thr Gly Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu
    770                 775                 780                 
Ala Val Glu Gly Met His Arg Glu Leu Val Phe Arg Phe Ile Glu Val
785                 790                 795                 800 
Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro His Leu Cys Glu His Ile
                805                 810                 815     
Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp Pro
            820                 825                 830         
Val Ala Gly Pro Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr Leu
        835                 840                 845             
Met Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met Met
    850                 855                 860                 
Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser
865                 870                 875                 880 
His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His Thr
                885                 890                 895     
Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys Leu
            900                 905                 910         
Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu
        915                 920                 925             
Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu
    930                 935                 940                 
Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe
945                 950                 955                 960 
Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser
                965                 970                 975     
Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp
            980                 985                 990         
Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg
        995                 1000                1005            
Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln Pro Ser Asn
    1010                1015                1020                
Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp
1025                1030                1035               1040 
Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile Lys Asp Leu
                1045                1050                1055    
Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg
            1060                1065                1070        
Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser
        1075                1080                1085            
Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys Ile His Leu
    1090                1095                1100                
Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu
1105                1110                1115               1120 
Val His
        


<210> 62
<211> 3369
<212> DNA
<213> Homo sapiens

<400> 62
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa aggtagactg gcgtcgttcc ttcatcacca ctgatgttaa tccttactat 480
gattcatttg tcagatggca atttttaaca ttaagagaaa gaaacaaaat taaatttggg 540
aagcggtata caatttactc tccgaaagat ggacagcctt gcatggatca tgatagacaa 600
actggagagg gtgttggacc tcaggaatat actttactca aattgaaggt gcttgagcca 660
tacccatcta aattaagtgg cctgaaaggt aaaaatattt tcttggtggc tgctactctc 720
agacctgaga ccatgtttgg gcagacaaat tgttgggttc gtcctgatat gaagtacatt 780
ggatttgaga cggtgaatgg tgatatattc atctgtaccc aaaaagcagc caggaatatg 840
tcataccagg gctttaccaa agacaatggc gtggtgcctg ttgttaagga attaatgggg 900
gaggaaattc ttggtgcatc actttctgca cctttaacat catacaaggt gatctatgtt 960
ctcccaatgc taactattaa ggaggataaa ggcactggtg tggttacaag tgttccttcc 1020
gactcccctg atgatattgc tgccctcaga gacttgaaga aaaagcaagc cttacgagca 1080
aaatatggaa ttagagatga catggtcttg ccatttgagc cggtgccagt cattgaaatc 1140
ccaggttttg gaaatctttc tgctgtaacc atttgtgatg agttgaaaat tcagagccag 1200
aatgaccggg aaaaacttgc agaagcaaag gagaagatat atctaaaagg attttatgag 1260
ggtatcatgt tggtggatgg atttaaagga cagaaggttc aagatgtaaa gaagactatt 1320
cagaaaaaga tgattgacgc tggagatgca cttatttaca tggaaccaga gaaacaagtg 1380
atgtccaggt cgtcagatga atgtgttgtg gctctgtgtg accagtggta cttggattat 1440
ggagaagaga attggaagaa acagacatct cagtgcttga agaacctgga aacattctgt 1500
gaggagacca ggaggaattt tgaagccacc ttaggttggc tacaagaaca tgcttgctca 1560
agaacttatg gtctaggcac tcacctgcct tgggatgagc agtggctgat tgaatcactt 1620
tctgactcca ctatttacat ggcattttac acagttgcac acctattgca ggggggtaac 1680
ttgcatggac aggcagagtc tccgctgggc attagaccgc aacagatgac caaggaagtt 1740
tgggattatg ttttcttcaa ggaggctcca tttcctaaga ctcagattgc aaaggaaaaa 1800
ttagatcagt taaagcagga gtttgaattc tggtatcctg ttgatcttcg cgtctctggc 1860
aaggatcttg ttccaaatca tctttcatat tacctttata atcatgtggc tatgtggccg 1920
gaacaaagtg acaaatggcc tacagctgtg agagcaaatg gacatctcct cctgaactct 1980
gagaagatgt caaaatccac aggcaacttc ctcactttga cccaagctat tgacaaattt 2040
tcagcagatg gaatgcgttt ggctctggct gatgctggtg acactgtaga agatgccaac 2100
tttgtggaag ccatggcaga tgcaggtatt ctccgtctgt acacctgggt agagtgggtg 2160
aaagaaatgg ttgccaactg ggacagccta agaagtggtc ctgccagcac tttcaatgat 2220
agagtttttg ccagtgaatt gaatgcagga attataaaaa cagatcaaaa ctatgaaaag 2280
atgatgttta aagaagcttt gaaaacaggg ttttttgagt ttcaggccgc aaaagataag 2340
taccgtgaat tggctgtgga agggatgcac agagaacttg tgttccggtt tattgaagtt 2400
cagacacttc tcctcgctcc attctgtcca catttgtgtg agcacatctg gacactcctg 2460
ggaaagcctg actcaattat gaatgcttca tggcctgtgg caggtcctgt taatgaagtt 2520
ttaatacact cctcacagta tcttatggaa gtaacacatg accttagact acgactcaag 2580
aactatatga tgccagctaa agggaagaag actgacaaac aacccctgca gaagccctca 2640
cattgcacca tctatgtggc aaagaactat ccaccttggc aacataccac cctgtctgtt 2700
ctacgtaaac actttgaggc caataacgga aaactgcctg acaacaaagt cattgctagt 2760
gaactaggca gtatgccaga actgaagaaa tacatgaaga aagtcatgcc atttgttgcc 2820
atgattaagg aaaatctgga gaagatgggg cctcgtattc tggatttgca attagaattt 2880
gatgaaaagg ctgtgcttat ggagaatata gtctatctga ctaattcgct tgagctagaa 2940
cacatagaag tcaagtttgc ctccgaagca gaagataaaa tcagggaaga ctgctgtcct 3000
gggaaaccac ttaatgtttt tagaatagaa cctggtgtgt ccgtttctct ggtgaatccc 3060
cagccatcca atggccactt ctcaaccaaa attgaaatca ggcaaggaga taactgtgat 3120
tccataatca ggcgtttaat gaaaatgaat cgaggaatta aagacctttc caaagtgaaa 3180
ctgatgagat ttgatgatcc actgttgggg cctcgacgag ttcctgtcct gggaaaggag 3240
tacaccgaga agacccccat ttctgagcat gctgttttca atgtggacct catgagcaag 3300
aaaattcatc tgactgagaa tgggataagg gtggatattg gcgatacaat aatctatctg 3360
gttcattaa                                                         3369

<210> 63
<211> 1158
<212> PRT
<213> Homo sapiens

<400> 63
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Val Pro Val Ile Glu Ile
                405                 410                 415     
Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu Leu Lys
            420                 425                 430         
Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys Glu Lys
        435                 440                 445             
Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp Gly Phe
    450                 455                 460                 
Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys Lys Met
465                 470                 475                 480 
Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys Gln Val
                485                 490                 495     
Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp Gln Trp
            500                 505                 510         
Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser Gln Cys
        515                 520                 525             
Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn Phe Glu
    530                 535                 540                 
Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr Tyr Gly
545                 550                 555                 560 
Leu Gly Thr His Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu Ser Leu
                565                 570                 575     
Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala His Leu Leu
            580                 585                 590         
Gln Gly Gly Asn Leu His Gly Gln Ala Glu Ser Pro Leu Gly Ile Arg
        595                 600                 605             
Pro Gln Gln Met Thr Lys Glu Val Trp Asp Tyr Val Phe Phe Lys Glu
    610                 615                 620                 
Ala Pro Phe Pro Lys Thr Gln Ile Ala Lys Glu Lys Leu Asp Gln Leu
625                 630                 635                 640 
Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu Arg Val Ser Gly
                645                 650                 655     
Lys Asp Leu Val Pro Asn His Leu Ser Tyr Tyr Leu Tyr Asn His Val
            660                 665                 670         
Ala Met Trp Pro Glu Gln Ser Asp Lys Trp Pro Thr Ala Val Arg Ala
        675                 680                 685             
Asn Gly His Leu Leu Leu Asn Ser Glu Lys Met Ser Lys Ser Thr Gly
    690                 695                 700                 
Asn Phe Leu Thr Leu Thr Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly
705                 710                 715                 720 
Met Arg Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn
                725                 730                 735     
Phe Val Glu Ala Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp
            740                 745                 750         
Val Glu Trp Val Lys Glu Met Val Ala Asn Trp Asp Ser Leu Arg Ser
        755                 760                 765             
Gly Pro Ala Ser Thr Phe Asn Asp Arg Val Phe Ala Ser Glu Leu Asn
    770                 775                 780                 
Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr Glu Lys Met Met Phe Lys
785                 790                 795                 800 
Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys
                805                 810                 815     
Tyr Arg Glu Leu Ala Val Glu Gly Met His Arg Glu Leu Val Phe Arg
            820                 825                 830         
Phe Ile Glu Val Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro His Leu
        835                 840                 845             
Cys Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile Met Asn
    850                 855                 860                 
Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile His Ser
865                 870                 875                 880 
Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys
                885                 890                 895     
Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu
            900                 905                 910         
Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro
        915                 920                 925             
Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn
    930                 935                 940                 
Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser
945                 950                 955                 960 
Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala
                965                 970                 975     
Met Ile Lys Glu Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu
            980                 985                 990         
Gln Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr
        995                 1000                1005            
Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser
    1010                1015                1020                
Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu
1025                1030                1035               1040 
Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro
                1045                1050                1055    
Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly
            1060                1065                1070        
Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly
        1075                1080                1085            
Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu
    1090                1095                1100                
Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys
1105                1110                1115               1120 
Thr Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys
                1125                1130                1135    
Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr
            1140                1145                1150        
Ile Ile Tyr Leu Val His
        1155            


<210> 64
<211> 3477
<212> DNA
<213> Homo sapiens

<400> 64
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa gtgccagtca ttgaaatccc aggttttgga 1260
aatctttctg ctgtaaccat ttgtgatgag ttgaaaattc agagccagaa tgaccgggaa 1320
aaacttgcag aagcaaagga gaagatatat ctaaaaggat tttatgaggg tatcatgttg 1380
gtggatggat ttaaaggaca gaaggttcaa gatgtaaaga agactattca gaaaaagatg 1440
attgacgctg gagatgcact tatttacatg gaaccagaga aacaagtgat gtccaggtcg 1500
tcagatgaat gtgttgtggc tctgtgtgac cagtggtact tggattatgg agaagagaat 1560
tggaagaaac agacatctca gtgcttgaag aacctggaaa cattctgtga ggagaccagg 1620
aggaattttg aagccacctt aggttggcta caagaacatg cttgctcaag aacttatggt 1680
ctaggcactc acctgccttg ggatgagcag tggctgattg aatcactttc tgactccact 1740
atttacatgg cattttacac agttgcacac ctattgcagg ggggtaactt gcatggacag 1800
gcagagtctc cgctgggcat tagaccgcaa cagatgacca aggaagtttg ggattatgtt 1860
ttcttcaagg aggctccatt tcctaagact cagattgcaa aggaaaaatt agatcagtta 1920
aagcaggagt ttgaattctg gtatcctgtt gatcttcgcg tctctggcaa ggatcttgtt 1980
ccaaatcatc tttcatatta cctttataat catgtggcta tgtggccgga acaaagtgac 2040
aaatggccta cagctgtgag agcaaatgga catctcctcc tgaactctga gaagatgtca 2100
aaatccacag gcaacttcct cactttgacc caagctattg acaaattttc agcagatgga 2160
atgcgtttgg ctctggctga tgctggtgac actgtagaag atgccaactt tgtggaagcc 2220
atggcagatg caggtattct ccgtctgtac acctgggtag agtgggtgaa agaaatggtt 2280
gccaactggg acagcctaag aagtggtcct gccagcactt tcaatgatag agtttttgcc 2340
agtgaattga atgcaggaat tataaaaaca gatcaaaact atgaaaagat gatgtttaaa 2400
gaagctttga aaacagggtt ttttgagttt caggccgcaa aagataagta ccgtgaattg 2460
gctgtggaag ggatgcacag agaacttgtg ttccggttta ttgaagttca gacacttctc 2520
ctcgctccat tctgtccaca tttgtgtgag cacatctgga cactcctggg aaagcctgac 2580
tcaattatga atgcttcatg gcctgtggca ggtcctgtta atgaagtttt aatacactcc 2640
tcacagtatc ttatggaagt aacacatgac cttagactac gactcaagaa ctatatgatg 2700
ccagctaaag ggaagaagac tgacaaacaa cccctgcaga agccctcaca ttgcaccatc 2760
tatgtggcaa agaactatcc accttggcaa cataccaccc tgtctgttct acgtaaacac 2820
tttgaggcca ataacggaaa actgcctgac aacaaagtca ttgctagtga actaggcagt 2880
atgccagaac tgaagaaata catgaagaaa gtcatgccat ttgttgccat gattaaggaa 2940
aatctggaga agatggggcc tcgtattctg gatttgcaat tagaatttga tgaaaaggct 3000
gtgcttatgg agaatatagt ctatctgact aattcgcttg agctagaaca catagaagtc 3060
aagtttgcct ccgaagcaga agataaaatc agggaagact gctgtcctgg gaaaccactt 3120
aatgttttta gaatagaacc tggtgtgtcc gtttctctgg tgaatcccca gccatccaat 3180
ggccacttct caaccaaaat tgaaatcagg caaggagata actgtgattc cataatcagg 3240
cgtttaatga aaatgaatcg aggaattaaa gacctttcca aagtgaaact gatgagattt 3300
gatgatccac tgttggggcc tcgacgagtt cctgtcctgg gaaaggagta caccgagaag 3360
acccccattt ctgagcatgc tgttttcaat gtggacctca tgagcaagaa aattcatctg 3420
actgagaatg ggataagggt ggatattggc gatacaataa tctatctggt tcattaa    3477

<210> 65
<211> 1105
<212> PRT
<213> Homo sapiens

<400> 65
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr
                405                 410                 415     
Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile
            420                 425                 430         
Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu
        435                 440                 445             
Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys
    450                 455                 460                 
Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp
465                 470                 475                 480 
Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys
                485                 490                 495     
Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys
            500                 505                 510         
Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp
        515                 520                 525             
Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser
    530                 535                 540                 
Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn
545                 550                 555                 560 
Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr
                565                 570                 575     
Tyr Gly Leu Gly Thr His Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu
            580                 585                 590         
Ser Leu Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala His
        595                 600                 605             
Leu Leu Gln Gly Gly Asn Leu His Gly Gln Ala Glu Ser Pro Leu Gly
    610                 615                 620                 
Ile Ser Asp Lys Trp Pro Thr Ala Val Arg Ala Asn Gly His Leu Leu
625                 630                 635                 640 
Leu Asn Ser Glu Lys Met Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu
                645                 650                 655     
Thr Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu
            660                 665                 670         
Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met
        675                 680                 685             
Ala Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys
    690                 695                 700                 
Glu Met Val Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr
705                 710                 715                 720 
Phe Asn Asp Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys
                725                 730                 735     
Thr Asp Gln Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr
            740                 745                 750         
Gly Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala
        755                 760                 765             
Val Glu Gly Met His Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln
    770                 775                 780                 
Thr Leu Leu Leu Ala Pro Phe Cys Pro His Leu Cys Glu His Ile Trp
785                 790                 795                 800 
Thr Leu Leu Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val
                805                 810                 815     
Ala Gly Pro Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met
            820                 825                 830         
Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro
        835                 840                 845             
Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His
    850                 855                 860                 
Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr
865                 870                 875                 880 
Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro
                885                 890                 895     
Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys
            900                 905                 910         
Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu Asn
        915                 920                 925             
Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp
    930                 935                 940                 
Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu
945                 950                 955                 960 
Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys
                965                 970                 975     
Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile
            980                 985                 990         
Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln Pro Ser Asn Gly
        995                 1000                1005            
His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp Ser
    1010                1015                1020                
Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile Lys Asp Leu Ser
1025                1030                1035               1040 
Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg
                1045                1050                1055    
Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu
            1060                1065                1070        
His Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys Ile His Leu Thr
        1075                1080                1085            
Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val
    1090                1095                1100                
His
1105


<210> 66
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 66
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa gccttacgag caaaatatgg aattagagat 1260
gacatggtct tgccatttga gccggtgcca gtcattgaaa tcccaggttt tggaaatctt 1320
tctgctgtaa ccatttgtga tgagttgaaa attcagagcc agaatgaccg ggaaaaactt 1380
gcagaagcaa aggagaagat atatctaaaa ggattttatg agggtatcat gttggtggat 1440
ggatttaaag gacagaaggt tcaagatgta aagaagacta ttcagaaaaa gatgattgac 1500
gctggagatg cacttattta catggaacca gagaaacaag tgatgtccag gtcgtcagat 1560
gaatgtgttg tggctctgtg tgaccagtgg tacttggatt atggagaaga gaattggaag 1620
aaacagacat ctcagtgctt gaagaacctg gaaacattct gtgaggagac caggaggaat 1680
tttgaagcca ccttaggttg gctacaagaa catgcttgct caagaactta tggtctaggc 1740
actcacctgc cttgggatga gcagtggctg attgaatcac tttctgactc cactatttac 1800
atggcatttt acacagttgc acacctattg caggggggta acttgcatgg acaggcagag 1860
tctccgctgg gcattagtga caaatggcct acagctgtga gagcaaatgg acatctcctc 1920
ctgaactctg agaagatgtc aaaatccaca ggcaacttcc tcactttgac ccaagctatt 1980
gacaaatttt cagcagatgg aatgcgtttg gctctggctg atgctggtga cactgtagaa 2040
gatgccaact ttgtggaagc catggcagat gcaggtattc tccgtctgta cacctgggta 2100
gagtgggtga aagaaatggt tgccaactgg gacagcctaa gaagtggtcc tgccagcact 2160
ttcaatgata gagtttttgc cagtgaattg aatgcaggaa ttataaaaac agatcaaaac 2220
tatgaaaaga tgatgtttaa agaagctttg aaaacagggt tttttgagtt tcaggccgca 2280
aaagataagt accgtgaatt ggctgtggaa gggatgcaca gagaacttgt gttccggttt 2340
attgaagttc agacacttct cctcgctcca ttctgtccac atttgtgtga gcacatctgg 2400
acactcctgg gaaagcctga ctcaattatg aatgcttcat ggcctgtggc aggtcctgtt 2460
aatgaagttt taatacactc ctcacagtat cttatggaag taacacatga ccttagacta 2520
cgactcaaga actatatgat gccagctaaa gggaagaaga ctgacaaaca acccctgcag 2580
aagccctcac attgcaccat ctatgtggca aagaactatc caccttggca acataccacc 2640
ctgtctgttc tacgtaaaca ctttgaggcc aataacggaa aactgcctga caacaaagtc 2700
attgctagtg aactaggcag tatgccagaa ctgaagaaat acatgaagaa agtcatgcca 2760
tttgttgcca tgattaagga aaatctggag aagatggggc ctcgtattct ggatttgcaa 2820
ttagaatttg atgaaaaggc tgtgcttatg gagaatatag tctatctgac taattcgctt 2880
gagctagaac acatagaagt caagtttgcc tccgaagcag aagataaaat cagggaagac 2940
tgctgtcctg ggaaaccact taatgttttt agaatagaac ctggtgtgtc cgtttctctg 3000
gtgaatcccc agccatccaa tggccacttc tcaaccaaaa ttgaaatcag gcaaggagat 3060
aactgtgatt ccataatcag gcgtttaatg aaaatgaatc gaggaattaa agacctttcc 3120
aaagtgaaac tgatgagatt tgatgatcca ctgttggggc ctcgacgagt tcctgtcctg 3180
ggaaaggagt acaccgagaa gacccccatt tctgagcatg ctgttttcaa tgtggacctc 3240
atgagcaaga aaattcatct gactgagaat gggataaggg tggatattgg cgatacaata 3300
atctatctgg ttcattaa                                               3318

<210> 67
<211> 1078
<212> PRT
<213> Homo sapiens

<400> 67
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser Tyr Lys
            260                 265                 270         
Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys Gly Thr
        275                 280                 285             
Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile Ala Ala
    290                 295                 300                 
Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr Gly Ile
305                 310                 315                 320 
Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile Glu Ile
                325                 330                 335     
Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu Leu Lys
            340                 345                 350         
Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys Glu Lys
        355                 360                 365             
Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp Gly Phe
    370                 375                 380                 
Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys Lys Met
385                 390                 395                 400 
Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys Gln Val
                405                 410                 415     
Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp Gln Trp
            420                 425                 430         
Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser Gln Cys
        435                 440                 445             
Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn Phe Glu
    450                 455                 460                 
Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr Tyr Gly
465                 470                 475                 480 
Leu Gly Thr His Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu Ser Leu
                485                 490                 495     
Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala His Leu Leu
            500                 505                 510         
Gln Gly Gly Asn Leu His Gly Gln Ala Glu Ser Pro Leu Gly Ile Arg
        515                 520                 525             
Pro Gln Gln Met Thr Lys Glu Val Trp Asp Tyr Val Phe Phe Lys Glu
    530                 535                 540                 
Ala Pro Phe Pro Lys Thr Gln Ile Ala Lys Glu Lys Leu Asp Gln Leu
545                 550                 555                 560 
Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu Arg Val Ser Gly
                565                 570                 575     
Lys Asp Leu Val Pro Asn His Leu Ser Tyr Tyr Leu Tyr Asn His Val
            580                 585                 590         
Ala Met Trp Pro Glu Gln Ser Asp Lys Trp Pro Thr Ala Val Arg Ala
        595                 600                 605             
Asn Gly His Leu Leu Leu Asn Ser Glu Lys Met Ser Lys Ser Thr Gly
    610                 615                 620                 
Asn Phe Leu Thr Leu Thr Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly
625                 630                 635                 640 
Met Arg Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn
                645                 650                 655     
Phe Val Glu Ala Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp
            660                 665                 670         
Val Glu Trp Val Lys Glu Met Val Ala Asn Trp Asp Ser Leu Arg Ser
        675                 680                 685             
Gly Pro Ala Ser Thr Phe Asn Asp Arg Val Phe Ala Ser Glu Leu Asn
    690                 695                 700                 
Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr Glu Lys Met Met Phe Lys
705                 710                 715                 720 
Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys
                725                 730                 735     
Tyr Arg Glu Leu Ala Val Glu Gly Met His Arg Glu Leu Val Phe Arg
            740                 745                 750         
Phe Ile Glu Val Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro His Leu
        755                 760                 765             
Cys Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile Met Asn
    770                 775                 780                 
Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile His Ser
785                 790                 795                 800 
Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys
                805                 810                 815     
Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu
            820                 825                 830         
Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro
        835                 840                 845             
Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn
    850                 855                 860                 
Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser
865                 870                 875                 880 
Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala
                885                 890                 895     
Met Ile Lys Glu Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu
            900                 905                 910         
Gln Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr
        915                 920                 925             
Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser
    930                 935                 940                 
Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu
945                 950                 955                 960 
Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro
                965                 970                 975     
Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly
            980                 985                 990         
Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly
        995                 1000                1005            
Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu
    1010                1015                1020                
Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys
1025                1030                1035               1040 
Thr Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys
                1045                1050                1055    
Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr
            1060                1065                1070        
Ile Ile Tyr Leu Val His
        1075            


<210> 68
<211> 3237
<212> DNA
<213> Homo sapiens

<400> 68
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga ggaaattctt 780
ggtgcatcac tttctgcacc tttaacatca tacaaggtga tctatgttct cccaatgcta 840
actattaagg aggataaagg cactggtgtg gttacaagtg ttccttccga ctcccctgat 900
gatattgctg ccctcagaga cttgaagaaa aagcaagcct tacgagcaaa atatggaatt 960
agagatgaca tggtcttgcc atttgagccg gtgccagtca ttgaaatccc aggttttgga 1020
aatctttctg ctgtaaccat ttgtgatgag ttgaaaattc agagccagaa tgaccgggaa 1080
aaacttgcag aagcaaagga gaagatatat ctaaaaggat tttatgaggg tatcatgttg 1140
gtggatggat ttaaaggaca gaaggttcaa gatgtaaaga agactattca gaaaaagatg 1200
attgacgctg gagatgcact tatttacatg gaaccagaga aacaagtgat gtccaggtcg 1260
tcagatgaat gtgttgtggc tctgtgtgac cagtggtact tggattatgg agaagagaat 1320
tggaagaaac agacatctca gtgcttgaag aacctggaaa cattctgtga ggagaccagg 1380
aggaattttg aagccacctt aggttggcta caagaacatg cttgctcaag aacttatggt 1440
ctaggcactc acctgccttg ggatgagcag tggctgattg aatcactttc tgactccact 1500
atttacatgg cattttacac agttgcacac ctattgcagg ggggtaactt gcatggacag 1560
gcagagtctc cgctgggcat tagaccgcaa cagatgacca aggaagtttg ggattatgtt 1620
ttcttcaagg aggctccatt tcctaagact cagattgcaa aggaaaaatt agatcagtta 1680
aagcaggagt ttgaattctg gtatcctgtt gatcttcgcg tctctggcaa ggatcttgtt 1740
ccaaatcatc tttcatatta cctttataat catgtggcta tgtggccgga acaaagtgac 1800
aaatggccta cagctgtgag agcaaatgga catctcctcc tgaactctga gaagatgtca 1860
aaatccacag gcaacttcct cactttgacc caagctattg acaaattttc agcagatgga 1920
atgcgtttgg ctctggctga tgctggtgac actgtagaag atgccaactt tgtggaagcc 1980
atggcagatg caggtattct ccgtctgtac acctgggtag agtgggtgaa agaaatggtt 2040
gccaactggg acagcctaag aagtggtcct gccagcactt tcaatgatag agtttttgcc 2100
agtgaattga atgcaggaat tataaaaaca gatcaaaact atgaaaagat gatgtttaaa 2160
gaagctttga aaacagggtt ttttgagttt caggccgcaa aagataagta ccgtgaattg 2220
gctgtggaag ggatgcacag agaacttgtg ttccggttta ttgaagttca gacacttctc 2280
ctcgctccat tctgtccaca tttgtgtgag cacatctgga cactcctggg aaagcctgac 2340
tcaattatga atgcttcatg gcctgtggca ggtcctgtta atgaagtttt aatacactcc 2400
tcacagtatc ttatggaagt aacacatgac cttagactac gactcaagaa ctatatgatg 2460
ccagctaaag ggaagaagac tgacaaacaa cccctgcaga agccctcaca ttgcaccatc 2520
tatgtggcaa agaactatcc accttggcaa cataccaccc tgtctgttct acgtaaacac 2580
tttgaggcca ataacggaaa actgcctgac aacaaagtca ttgctagtga actaggcagt 2640
atgccagaac tgaagaaata catgaagaaa gtcatgccat ttgttgccat gattaaggaa 2700
aatctggaga agatggggcc tcgtattctg gatttgcaat tagaatttga tgaaaaggct 2760
gtgcttatgg agaatatagt ctatctgact aattcgcttg agctagaaca catagaagtc 2820
aagtttgcct ccgaagcaga agataaaatc agggaagact gctgtcctgg gaaaccactt 2880
aatgttttta gaatagaacc tggtgtgtcc gtttctctgg tgaatcccca gccatccaat 2940
ggccacttct caaccaaaat tgaaatcagg caaggagata actgtgattc cataatcagg 3000
cgtttaatga aaatgaatcg aggaattaaa gacctttcca aagtgaaact gatgagattt 3060
gatgatccac tgttggggcc tcgacgagtt cctgtcctgg gaaaggagta caccgagaag 3120
acccccattt ctgagcatgc tgttttcaat gtggacctca tgagcaagaa aattcatctg 3180
actgagaatg ggataagggt ggatattggc gatacaataa tctatctggt tcattaa    3237

<210> 69
<211> 757
<212> PRT
<213> Homo sapiens

<400> 69
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Ala Lys Asp Lys Tyr
                405                 410                 415     
Arg Glu Leu Ala Val Glu Gly Met His Arg Glu Leu Val Phe Arg Phe
            420                 425                 430         
Ile Glu Val Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro His Leu Cys
        435                 440                 445             
Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile Met Asn Ala
    450                 455                 460                 
Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile His Ser Ser
465                 470                 475                 480 
Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys Asn
                485                 490                 495     
Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln
            500                 505                 510         
Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp
        515                 520                 525             
Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn Asn
    530                 535                 540                 
Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met
545                 550                 555                 560 
Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala Met
                565                 570                 575     
Ile Lys Glu Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln
            580                 585                 590         
Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu
        595                 600                 605             
Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu
    610                 615                 620                 
Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn
625                 630                 635                 640 
Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln
                645                 650                 655     
Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp
            660                 665                 670         
Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile
        675                 680                 685             
Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu
    690                 695                 700                 
Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr
705                 710                 715                 720 
Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys
                725                 730                 735     
Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile
            740                 745                 750         
Ile Tyr Leu Val His
        755         


<210> 70
<211> 2274
<212> DNA
<213> Homo sapiens

<400> 70
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa gccgcaaaag ataagtaccg tgaattggct 1260
gtggaaggga tgcacagaga acttgtgttc cggtttattg aagttcagac acttctcctc 1320
gctccattct gtccacattt gtgtgagcac atctggacac tcctgggaaa gcctgactca 1380
attatgaatg cttcatggcc tgtggcaggt cctgttaatg aagttttaat acactcctca 1440
cagtatctta tggaagtaac acatgacctt agactacgac tcaagaacta tatgatgcca 1500
gctaaaggga agaagactga caaacaaccc ctgcagaagc cctcacattg caccatctat 1560
gtggcaaaga actatccacc ttggcaacat accaccctgt ctgttctacg taaacacttt 1620
gaggccaata acggaaaact gcctgacaac aaagtcattg ctagtgaact aggcagtatg 1680
ccagaactga agaaatacat gaagaaagtc atgccatttg ttgccatgat taaggaaaat 1740
ctggagaaga tggggcctcg tattctggat ttgcaattag aatttgatga aaaggctgtg 1800
cttatggaga atatagtcta tctgactaat tcgcttgagc tagaacacat agaagtcaag 1860
tttgcctccg aagcagaaga taaaatcagg gaagactgct gtcctgggaa accacttaat 1920
gtttttagaa tagaacctgg tgtgtccgtt tctctggtga atccccagcc atccaatggc 1980
cacttctcaa ccaaaattga aatcaggcaa ggagataact gtgattccat aatcaggcgt 2040
ttaatgaaaa tgaatcgagg aattaaagac ctttccaaag tgaaactgat gagatttgat 2100
gatccactgt tggggcctcg acgagttcct gtcctgggaa aggagtacac cgagaagacc 2160
cccatttctg agcatgctgt tttcaatgtg gacctcatga gcaagaaaat tcatctgact 2220
gagaatggga taagggtgga tattggcgat acaataatct atctggttca ttaa       2274

<210> 71
<211> 626
<212> PRT
<213> Homo sapiens

<400> 71
Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile
 1               5                  10                  15      
Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val
            20                  25                  30          
Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val
        35                  40                  45              
Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr
    50                  55                  60                  
Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys
65                  70                  75                  80  
Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro
                85                  90                  95      
Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly
            100                 105                 110         
Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser
        115                 120                 125             
Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys
    130                 135                 140                 
Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile
145                 150                 155                 160 
Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu
                165                 170                 175     
Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu
            180                 185                 190         
Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr
        195                 200                 205             
Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr
    210                 215                 220                 
Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr
225                 230                 235                 240 
Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly
                245                 250                 255     
Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu
            260                 265                 270         
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
        275                 280                 285             
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
    290                 295                 300                 
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
305                 310                 315                 320 
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
                325                 330                 335     
Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu
            340                 345                 350         
Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser
        355                 360                 365             
Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys
    370                 375                 380                 
Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile
385                 390                 395                 400 
Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Asn Asn Gly Lys Leu
                405                 410                 415     
Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu
            420                 425                 430         
Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu
        435                 440                 445             
Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe
    450                 455                 460                 
Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser
465                 470                 475                 480 
Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp
                485                 490                 495     
Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg
            500                 505                 510         
Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln Pro Ser Asn
        515                 520                 525             
Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp
    530                 535                 540                 
Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile Lys Asp Leu
545                 550                 555                 560 
Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg
                565                 570                 575     
Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser
            580                 585                 590         
Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys Ile His Leu
        595                 600                 605             
Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu
    610                 615                 620                 
Val His
625     


<210> 72
<211> 1881
<212> DNA
<213> Homo sapiens

<400> 72
atggcggaaa gaaaaggaac agccaaagtg gactttttga agaagattga gaaagaaatc 60
caacagaaat gggatactga gagagtgttt gaggtcaatg catctaattt agagaaacag 120
accagcaagg gcaagtattt tgtaaccttc ccatatccat atatgaatgg acgccttcat 180
ttgggacaca cgttttcttt atccaaatgt gagtttgctg tagggtacca gcgattgaaa 240
ggaaaatgtt gtctgtttcc ctttggcctg cactgtactg gaatgcctat taaggcatgt 300
gctgataagt tgaaaagaga aatagagctg tatggttgcc cccctgattt tccagatgaa 360
gaagaggaag aggaagaaac cagtgttaaa acagaagata taataattaa ggataaagct 420
aaaggaaaaa agagtaaagc tgctgctaaa gctggatctt ctaaatacca gtggggcatt 480
atgaaatccc ttggcctgtc tgatgaagag atagtaaaat tttctgaagc agaacattgg 540
cttgattatt tcccgccact ggctattcag gatttaaaaa gaatgggttt gaaggtagac 600
tggcgtcgtt ccttcatcac cactgatgtt aatccttact atgattcatt tgtcagatgg 660
caatttttaa cattaagaga aagaaacaaa attaaatttg ggaagcggta tacaatttac 720
tctccgaaag atggacagcc ttgcatggat catgatagac aaactggaga gggtgttgga 780
cctcaggaat atactttact caaattgaag gtgcttgagc catacccatc taaattaagt 840
ggcctgaaag gtaaaaatat tttcttggtg gctgctactc tcagacctga gaccatgttt 900
gggcagacaa attgttgggt tcgtcctgat atgaagtaca ttggatttga gacggtgaat 960
ggtgatatat tcatctgtac ccaaaaagca gccaggaata tgtcatacca gggctttacc 1020
aaagacaatg gcgtggtgcc tgttgttaag gaattaatgg gggaggaaat tcttggtgca 1080
tcactttctg cacctttaac atcatacaag gtgatctatg ttctcccaat gctaactatt 1140
aaggaggata aaggcactgg tgtggttaca agtgttcctt ccgactcccc tgatgatatt 1200
gctgccctca gagacttgaa gaaaaagcaa gccaataacg gaaaactgcc tgacaacaaa 1260
gtcattgcta gtgaactagg cagtatgcca gaactgaaga aatacatgaa gaaagtcatg 1320
ccatttgttg ccatgattaa ggaaaatctg gagaagatgg ggcctcgtat tctggatttg 1380
caattagaat ttgatgaaaa ggctgtgctt atggagaata tagtctatct gactaattcg 1440
cttgagctag aacacataga agtcaagttt gcctccgaag cagaagataa aatcagggaa 1500
gactgctgtc ctgggaaacc acttaatgtt tttagaatag aacctggtgt gtccgtttct 1560
ctggtgaatc cccagccatc caatggccac ttctcaacca aaattgaaat caggcaagga 1620
gataactgtg attccataat caggcgttta atgaaaatga atcgaggaat taaagacctt 1680
tccaaagtga aactgatgag atttgatgat ccactgttgg ggcctcgacg agttcctgtc 1740
ctgggaaagg agtacaccga gaagaccccc atttctgagc atgctgtttt caatgtggac 1800
ctcatgagca agaaaattca tctgactgag aatgggataa gggtggatat tggcgataca 1860
ataatctatc tggttcatta a                                           1881

<210> 73
<211> 61
<212> PRT
<213> Homo sapiens

<400> 73
Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val Pro Val Leu
 1               5                  10                  15      
Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His Ala Val Phe
            20                  25                  30          
Asn Val Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu Asn Gly Ile
        35                  40                  45              
Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His
    50                  55                  60      


<210> 74
<211> 186
<212> DNA
<213> Homo sapiens

<400> 74
atgagatttg atgatccact gttggggcct cgacgagttc ctgtcctggg aaaggagtac 60
accgagaaga cccccatttc tgagcatgct gttttcaatg tggacctcat gagcaagaaa 120
attcatctga ctgagaatgg gataagggtg gatattggcg atacaataat ctatctggtt 180
cattaa                                                            186

<210> 75
<211> 460
<212> PRT
<213> Homo sapiens

<400> 75
Met Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu Thr Gln Ala Ile Asp
 1               5                  10                  15      
Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu Ala Asp Ala Gly Asp
            20                  25                  30          
Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met Ala Asp Ala Gly Ile
        35                  40                  45              
Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys Glu Met Val Ala Asn
    50                  55                  60                  
Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr Phe Asn Asp Arg Val
65                  70                  75                  80  
Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr
                85                  90                  95      
Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe
            100                 105                 110         
Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala Val Glu Gly Met His
        115                 120                 125             
Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln Thr Leu Leu Leu Ala
    130                 135                 140                 
Pro Phe Cys Pro His Leu Cys Glu His Ile Trp Thr Leu Leu Gly Lys
145                 150                 155                 160 
Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val Ala Gly Pro Val Asn
                165                 170                 175     
Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu Val Thr His Asp
            180                 185                 190         
Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys
        195                 200                 205             
Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys Thr Ile Tyr Val
    210                 215                 220                 
Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu Ser Val Leu Arg
225                 230                 235                 240 
Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile
                245                 250                 255     
Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys Tyr Met Lys Lys
            260                 265                 270         
Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu Glu Lys Met Gly
        275                 280                 285             
Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu Lys Ala Val Leu
    290                 295                 300                 
Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu Glu His Ile
305                 310                 315                 320 
Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys
                325                 330                 335     
Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu Pro Gly Val Ser
            340                 345                 350         
Val Ser Leu Val Asn Pro Gln Pro Ser Asn Gly His Phe Ser Thr Lys
        355                 360                 365             
Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu
    370                 375                 380                 
Met Lys Met Asn Arg Gly Ile Lys Asp Leu Ser Lys Val Lys Leu Met
385                 390                 395                 400 
Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val Pro Val Leu Gly
                405                 410                 415     
Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His Ala Val Phe Asn
            420                 425                 430         
Val Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu Asn Gly Ile Arg
        435                 440                 445             
Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His
    450                 455                 460 


<210> 76
<211> 1383
<212> DNA
<213> Homo sapiens

<400> 76
atgtcaaaat ccacaggcaa cttcctcact ttgacccaag ctattgacaa attttcagca 60
gatggaatgc gtttggctct ggctgatgct ggtgacactg tagaagatgc caactttgtg 120
gaagccatgg cagatgcagg tattctccgt ctgtacacct gggtagagtg ggtgaaagaa 180
atggttgcca actgggacag cctaagaagt ggtcctgcca gcactttcaa tgatagagtt 240
tttgccagtg aattgaatgc aggaattata aaaacagatc aaaactatga aaagatgatg 300
tttaaagaag ctttgaaaac agggtttttt gagtttcagg ccgcaaaaga taagtaccgt 360
gaattggctg tggaagggat gcacagagaa cttgtgttcc ggtttattga agttcagaca 420
cttctcctcg ctccattctg tccacatttg tgtgagcaca tctggacact cctgggaaag 480
cctgactcaa ttatgaatgc ttcatggcct gtggcaggtc ctgttaatga agttttaata 540
cactcctcac agtatcttat ggaagtaaca catgacctta gactacgact caagaactat 600
atgatgccag ctaaagggaa gaagactgac aaacaacccc tgcagaagcc ctcacattgc 660
accatctatg tggcaaagaa ctatccacct tggcaacata ccaccctgtc tgttctacgt 720
aaacactttg aggccaataa cggaaaactg cctgacaaca aagtcattgc tagtgaacta 780
ggcagtatgc cagaactgaa gaaatacatg aagaaagtca tgccatttgt tgccatgatt 840
aaggaaaatc tggagaagat ggggcctcgt attctggatt tgcaattaga atttgatgaa 900
aaggctgtgc ttatggagaa tatagtctat ctgactaatt cgcttgagct agaacacata 960
gaagtcaagt ttgcctccga agcagaagat aaaatcaggg aagactgctg tcctgggaaa 1020
ccacttaatg tttttagaat agaacctggt gtgtccgttt ctctggtgaa tccccagcca 1080
tccaatggcc acttctcaac caaaattgaa atcaggcaag gagataactg tgattccata 1140
atcaggcgtt taatgaaaat gaatcgagga attaaagacc tttccaaagt gaaactgatg 1200
agatttgatg atccactgtt ggggcctcga cgagttcctg tcctgggaaa ggagtacacc 1260
gagaagaccc ccatttctga gcatgctgtt ttcaatgtgg acctcatgag caagaaaatt 1320
catctgactg agaatgggat aagggtggat attggcgata caataatcta tctggttcat 1380
taa                                                               1383

<210> 77
<211> 50
<212> DNA
<213> Homo sapiens

<400> 77
taaggataaa gctaaaggaa aaaaggtaga ctggcgtcgt tccttcatca            50

<210> 78
<211> 16
<212> PRT
<213> Homo sapiens

<400> 78
Lys Asp Lys Ala Lys Gly Lys Lys Val Asp Trp Arg Arg Ser Phe Ile
 1               5                  10                  15      


<210> 79
<211> 50
<212> DNA
<213> Homo sapiens

<400> 79
cctcagagac ttgaagaaaa agcaagtgcc agtcattgaa atcccaggtt            50

<210> 80
<211> 16
<212> PRT
<213> Homo sapiens

<400> 80
Leu Arg Asp Leu Lys Lys Lys Gln Val Pro Val Ile Glu Ile Pro Gly
 1               5                  10                  15      


<210> 81
<211> 50
<212> DNA
<213> Homo sapiens

<400> 81
aggcagagtc tccgctgggc attagtgaca aatggcctac agctgtgaga            50

<210> 82
<211> 16
<212> PRT
<213> Homo sapiens

<400> 82
Ala Glu Ser Pro Leu Gly Ile Ser Asp Lys Trp Pro Thr Ala Val Arg
 1               5                  10                  15      


<210> 83
<211> 50
<212> DNA
<213> Homo sapiens

<400> 83
ggatcatgat agacaaactg gagaggaaat tcttggtgca tcactttctg            50

<210> 84
<211> 16
<212> PRT
<213> Homo sapiens

<400> 84
Asp His Asp Arg Gln Thr Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser
 1               5                  10                  15      


<210> 85
<211> 50
<212> DNA
<213> Homo sapiens

<400> 85
cctcagagac ttgaagaaaa agcaagccgc aaaagataag taccgtgaat            50

<210> 86
<211> 16
<212> PRT
<213> Homo sapiens

<400> 86
Leu Arg Asp Leu Lys Lys Lys Gln Ala Ala Lys Asp Lys Tyr Arg Glu
 1               5                  10                  15      


<210> 87
<211> 50
<212> DNA
<213> Homo sapiens

<400> 87
cctcagagac ttgaagaaaa agcaagccaa taacggaaaa ctgcctgaca            50

<210> 88
<211> 16
<212> PRT
<213> Homo sapiens

<400> 88
Leu Arg Asp Leu Lys Lys Lys Gln Ala Asn Asn Gly Lys Leu Pro Asp
 1               5                  10                  15      


<210> 89
<211> 50
<212> DNA
<213> Homo sapiens

<400> 89
cctcagagac ttgaagaaaa agcaaacctt tccaaagtga aactgatgag            50

<210> 90
<211> 5
<212> PRT
<213> Homo sapiens

<400> 90
Met Arg Phe Asp Asp
 1               5  


<210> 91
<211> 50
<212> DNA
<213> Homo sapiens

<400> 91
gcttgctcaa gaacttatgg tctagtgaca aatggcctac agctgtgaga            50

<210> 92

<400> 92
 000

<210> 93
<211> 50
<212> DNA
<213> Homo sapiens

<400> 93
atgtggctat gtggccggaa caaagatgtc aaaatccaca ggcaacttcc            50

<210> 94
<211> 8
<212> PRT
<213> Homo sapiens

<400> 94
Met Ser Lys Ser Thr Gly Asn Phe
 1               5              


<210> 95
<211> 165
<212> PRT
<213> Homo sapiens

<400> 95
Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu
 1               5                  10                  15      
Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu
            20                  25                  30          
Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn
        35                  40                  45              
Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln
    50                  55                  60                  
Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp
65                  70                  75                  80  
Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile
                85                  90                  95      
Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu
            100                 105                 110         
Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr
        115                 120                 125             
Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys
    130                 135                 140                 
Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile
145                 150                 155                 160 
Ile Tyr Leu Val His
                165 


<210> 96
<211> 498
<212> DNA
<213> Homo sapiens

<400> 96
ttagaatttg atgaaaaggc tgtgcttatg gagaatatag tctatctgac taattcgctt 60
gagctagaac acatagaagt caagtttgcc tccgaagcag aagataaaat cagggaagac 120
tgctgtcctg ggaaaccact taatgttttt agaatagaac ctggtgtgtc cgtttctctg 180
gtgaatcccc agccatccaa tggccacttc tcaaccaaaa ttgaaatcag gcaaggagat 240
aactgtgatt ccataatcag gcgtttaatg aaaatgaatc gaggaattaa agacctttcc 300
aaagtgaaac tgatgagatt tgatgatcca ctgttggggc ctcgacgagt tcctgtcctg 360
ggaaaggagt acaccgagaa gacccccatt tctgagcatg ctgttttcaa tgtggacctc 420
atgagcaaga aaattcatct gactgagaat gggataaggg tggatattgg cgatacaata 480
atctatctgg ttcattaa                                               498

<210> 97
<211> 294
<212> PRT
<213> Homo sapiens

<400> 97
Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile His Ser
 1               5                  10                  15      
Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys
            20                  25                  30          
Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu
        35                  40                  45              
Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro
    50                  55                  60                  
Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn
65                  70                  75                  80  
Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser
                85                  90                  95      
Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala
            100                 105                 110         
Met Ile Lys Glu Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu
        115                 120                 125             
Gln Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr
    130                 135                 140                 
Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser
145                 150                 155                 160 
Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu
                165                 170                 175     
Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro
            180                 185                 190         
Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly
        195                 200                 205             
Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly
    210                 215                 220                 
Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu
225                 230                 235                 240 
Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys
                245                 250                 255     
Thr Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys
            260                 265                 270         
Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr
        275                 280                 285             
Ile Ile Tyr Leu Val His
    290                 


<210> 98
<211> 885
<212> DNA
<213> Homo sapiens

<400> 98
gcttcatggc ctgtggcagg tcctgttaat gaagttttaa tacactcctc acagtatctt 60
atggaagtaa cacatgacct tagactacga ctcaagaact atatgatgcc agctaaaggg 120
aagaagactg acaaacaacc cctgcagaag ccctcacatt gcaccatcta tgtggcaaag 180
aactatccac cttggcaaca taccaccctg tctgttctac gtaaacactt tgaggccaat 240
aacggaaaac tgcctgacaa caaagtcatt gctagtgaac taggcagtat gccagaactg 300
aagaaataca tgaagaaagt catgccattt gttgccatga ttaaggaaaa tctggagaag 360
atggggcctc gtattctgga tttgcaatta gaatttgatg aaaaggctgt gcttatggag 420
aatatagtct atctgactaa ttcgcttgag ctagaacaca tagaagtcaa gtttgcctcc 480
gaagcagaag ataaaatcag ggaagactgc tgtcctggga aaccacttaa tgtttttaga 540
atagaacctg gtgtgtccgt ttctctggtg aatccccagc catccaatgg ccacttctca 600
accaaaattg aaatcaggca aggagataac tgtgattcca taatcaggcg tttaatgaaa 660
atgaatcgag gaattaaaga cctttccaaa gtgaaactga tgagatttga tgatccactg 720
ttggggcctc gacgagttcc tgtcctggga aaggagtaca ccgagaagac ccccatttct 780
gagcatgctg ttttcaatgt ggacctcatg agcaagaaaa ttcatctgac tgagaatggg 840
ataagggtgg atattggcga tacaataatc tatctggttc attaa                 885

<210> 99
<211> 186
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 99
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu
            20                  25                  30          
Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val
        35                  40                  45              
Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro
    50                  55                  60                  
Gly Lys Pro Leu Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser
65                  70                  75                  80  
Leu Val Asn Pro Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu
                85                  90                  95      
Ile Arg Gln Gly Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys
            100                 105                 110         
Met Asn Arg Gly Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe
        115                 120                 125             
Asp Asp Pro Leu Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu
    130                 135                 140                 
Tyr Thr Glu Lys Thr Pro Ile Ser Glu His Ala Val Phe Asn Val Asp
145                 150                 155                 160 
Leu Met Ser Lys Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp
                165                 170                 175     
Ile Gly Asp Thr Ile Ile Tyr Leu Val His
            180                 185     


<210> 100
<211> 186
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 100
Met Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr
 1               5                  10                  15      
Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser
            20                  25                  30          
Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu
        35                  40                  45              
Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn Pro
    50                  55                  60                  
Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly
65                  70                  75                  80  
Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg Gly
                85                  90                  95      
Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro Leu
            100                 105                 110         
Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys
        115                 120                 125             
Thr Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser Lys
    130                 135                 140                 
Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr
145                 150                 155                 160 
Ile Ile Tyr Leu Val His Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                165                 170                 175     
Leu Asp Ser Thr His His His His His His
            180                 185     


<210> 101
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 101
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu
            20                  25                  30          
Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu
        35                  40                  45              
Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr
    50                  55                  60                  
Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala
65                  70                  75                  80  
Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys
                85                  90                  95      
His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala
            100                 105                 110         
Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val
        115                 120                 125             
Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu Glu Lys Met Gly Pro
    130                 135                 140                 
Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu Lys Ala Val Leu Met
145                 150                 155                 160 
Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu
                165                 170                 175     
Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys
            180                 185                 190         
Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val
        195                 200                 205             
Ser Leu Val Asn Pro Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile
    210                 215                 220                 
Glu Ile Arg Gln Gly Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met
225                 230                 235                 240 
Lys Met Asn Arg Gly Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg
                245                 250                 255     
Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys
            260                 265                 270         
Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His Ala Val Phe Asn Val
        275                 280                 285             
Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val
    290                 295                 300                 
Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His
305                 310                 315 


<210> 102
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 102
Met Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile His
 1               5                  10                  15      
Ser Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg Leu
            20                  25                  30          
Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro
        35                  40                  45              
Leu Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro
    50                  55                  60                  
Pro Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala
65                  70                  75                  80  
Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly
                85                  90                  95      
Ser Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val
            100                 105                 110         
Ala Met Ile Lys Glu Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp
        115                 120                 125             
Leu Gln Leu Glu Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val
    130                 135                 140                 
Tyr Leu Thr Asn Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala
145                 150                 155                 160 
Ser Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro
                165                 170                 175     
Leu Asn Val Phe Arg Ile Glu Pro Gly Val Ser Val Ser Leu Val Asn
            180                 185                 190         
Pro Gln Pro Ser Asn Gly His Phe Ser Thr Lys Ile Glu Ile Arg Gln
        195                 200                 205             
Gly Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu Met Lys Met Asn Arg
    210                 215                 220                 
Gly Ile Lys Asp Leu Ser Lys Val Lys Leu Met Arg Phe Asp Asp Pro
225                 230                 235                 240 
Leu Leu Gly Pro Arg Arg Val Pro Val Leu Gly Lys Glu Tyr Thr Glu
                245                 250                 255     
Lys Thr Pro Ile Ser Glu His Ala Val Phe Asn Val Asp Leu Met Ser
            260                 265                 270         
Lys Lys Ile His Leu Thr Glu Asn Gly Ile Arg Val Asp Ile Gly Asp
        275                 280                 285             
Thr Ile Ile Tyr Leu Val His Gly Lys Pro Ile Pro Asn Pro Leu Leu
    290                 295                 300                 
Gly Leu Asp Ser Thr His His His His His His
305                 310                 315 


<210> 103
<211> 81
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 103
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg
            20                  25                  30          
Val Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu
        35                  40                  45              
His Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys Ile His Leu Thr
    50                  55                  60                  
Glu Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val
65                  70                  75                  80  
His
    


<210> 104
<211> 81
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 104
Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val Pro Val Leu
 1               5                  10                  15      
Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His Ala Val Phe
            20                  25                  30          
Asn Val Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu Asn Gly Ile
        35                  40                  45              
Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His Gly Lys Pro
    50                  55                  60                  
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
65                  70                  75                  80  
His
    


<210> 105
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 105
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu Thr
            20                  25                  30          
Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu Ala
        35                  40                  45              
Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met Ala
    50                  55                  60                  
Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys Glu
65                  70                  75                  80  
Met Val Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr Phe
                85                  90                  95      
Asn Asp Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys Thr
            100                 105                 110         
Asp Gln Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr Gly
        115                 120                 125             
Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala Val
    130                 135                 140                 
Glu Gly Met His Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln Thr
145                 150                 155                 160 
Leu Leu Leu Ala Pro Phe Cys Pro His Leu Cys Glu His Ile Trp Thr
                165                 170                 175     
Leu Leu Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val Ala
            180                 185                 190         
Gly Pro Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu
        195                 200                 205             
Val Thr His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala
    210                 215                 220                 
Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys
225                 230                 235                 240 
Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu
                245                 250                 255     
Ser Val Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp
            260                 265                 270         
Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys
        275                 280                 285             
Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu
    290                 295                 300                 
Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu
305                 310                 315                 320 
Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu
                325                 330                 335     
Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile
            340                 345                 350         
Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu
        355                 360                 365             
Pro Gly Val Ser Val Ser Leu Val Asn Pro Gln Pro Ser Asn Gly His
    370                 375                 380                 
Phe Ser Thr Lys Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp Ser Ile
385                 390                 395                 400 
Ile Arg Arg Leu Met Lys Met Asn Arg Gly Ile Lys Asp Leu Ser Lys
                405                 410                 415     
Val Lys Leu Met Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val
            420                 425                 430         
Pro Val Leu Gly Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His
        435                 440                 445             
Ala Val Phe Asn Val Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu
    450                 455                 460                 
Asn Gly Ile Arg Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His
465                 470                 475                 480 


<210> 106
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 106
Met Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu Thr Gln Ala Ile Asp
 1               5                  10                  15      
Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu Ala Asp Ala Gly Asp
            20                  25                  30          
Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met Ala Asp Ala Gly Ile
        35                  40                  45              
Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys Glu Met Val Ala Asn
    50                  55                  60                  
Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr Phe Asn Asp Arg Val
65                  70                  75                  80  
Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr
                85                  90                  95      
Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe
            100                 105                 110         
Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala Val Glu Gly Met His
        115                 120                 125             
Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln Thr Leu Leu Leu Ala
    130                 135                 140                 
Pro Phe Cys Pro His Leu Cys Glu His Ile Trp Thr Leu Leu Gly Lys
145                 150                 155                 160 
Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val Ala Gly Pro Val Asn
                165                 170                 175     
Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu Val Thr His Asp
            180                 185                 190         
Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys
        195                 200                 205             
Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys Thr Ile Tyr Val
    210                 215                 220                 
Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu Ser Val Leu Arg
225                 230                 235                 240 
Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile
                245                 250                 255     
Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys Tyr Met Lys Lys
            260                 265                 270         
Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu Glu Lys Met Gly
        275                 280                 285             
Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu Lys Ala Val Leu
    290                 295                 300                 
Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu Glu His Ile
305                 310                 315                 320 
Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile Arg Glu Asp Cys
                325                 330                 335     
Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu Pro Gly Val Ser
            340                 345                 350         
Val Ser Leu Val Asn Pro Gln Pro Ser Asn Gly His Phe Ser Thr Lys
        355                 360                 365             
Ile Glu Ile Arg Gln Gly Asp Asn Cys Asp Ser Ile Ile Arg Arg Leu
    370                 375                 380                 
Met Lys Met Asn Arg Gly Ile Lys Asp Leu Ser Lys Val Lys Leu Met
385                 390                 395                 400 
Arg Phe Asp Asp Pro Leu Leu Gly Pro Arg Arg Val Pro Val Leu Gly
                405                 410                 415     
Lys Glu Tyr Thr Glu Lys Thr Pro Ile Ser Glu His Ala Val Phe Asn
            420                 425                 430         
Val Asp Leu Met Ser Lys Lys Ile His Leu Thr Glu Asn Gly Ile Arg
        435                 440                 445             
Val Asp Ile Gly Asp Thr Ile Ile Tyr Leu Val His Gly Lys Pro Ile
    450                 455                 460                 
Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
465                 470                 475                 480 


<210> 107
<211> 507
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 107
ctggaattcg acgagaaggc ggtcctgatg gagaacatcg tgtatttgac caactccctg 60
gaactggagc acattgaggt gaagttcgca agcgaagcgg aggataaaat ccgcgaggat 120
tgttgcccgg gtaaaccgct gaatgtcttt cgtatcgagc cgggtgtgtc cgtcagcctg 180
gttaatccgc agccgagcaa tggtcatttc agcacgaaga tcgagatccg tcaaggtgat 240
aattgcgact ctatcattcg tcgtctgatg aaaatgaacc gcggcattaa ggacctgagc 300
aaggttaaac tgatgcgttt cgatgacccg ctgctgggcc cgcgccgcgt tccagttctg 360
ggcaaagaat acaccgaaaa gacgcctatc agcgagcatg ccgtgtttaa cgtggacctg 420
atgagcaaga aaattcacct gactgaaaac ggtattcgtg tcgacattgg cgataccatc 480
atttacttgg tccactaatg actcgag                                     507

<210> 108
<211> 894
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 108
gcaagctggc cggtagcagg tccggtaaac gaagtcctga tccacagctc gcagtacttg 60
atggaagtga cgcacgatct gcgtttgcgt ctgaagaact acatgatgcc agcgaaaggt 120
aagaaaactg acaaacaacc gctgcagaag ccttcccatt gtaccatcta cgtcgcaaag 180
aactacccac cgtggcaaca caccaccctg agcgtcctgc gtaaacactt cgaggcgaat 240
aacggtaagc tgccggacaa taaggttatc gccagcgaac tgggcagcat gccggaactg 300
aagaaataca tgaagaaagt gatgccgttc gtcgcaatga tcaaagagaa tttggagaaa 360
atgggcccgc gtatcttgga cctgcagctg gaatttgacg aaaaggcggt tctgatggag 420
aacatcgtgt atctgacgaa cagcctggag ctggagcaca tcgaggttaa attcgcgtcc 480
gaagccgaag ataaaattcg tgaagattgc tgtccgggta agccgctgaa tgtgtttcgt 540
attgagcctg gtgtgagcgt cagcctggtc aacccgcagc cgagcaacgg ccatttcagc 600
acgaagattg agatccgtca aggtgataat tgcgattcca ttattcgtcg cttgatgaaa 660
atgaatcgcg gcattaagga cctgtctaaa gttaaactga tgcgctttga cgacccgctg 720
ctgggtccgc gccgcgttcc ggtcctgggc aaagagtata ccgagaaaac cccgatcagc 780
gagcatgctg tgtttaacgt ggacctgatg agcaagaaga tccatctgac ggaaaatggt 840
attcgtgttg atattggtga taccattatt tatctggttc actaatgact cgag       894

<210> 109
<211> 192
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 109
cgcttcgacg atccactgct gggcccacgc cgcgtaccgg tgctgggtaa agagtacacc 60
gaaaagactc cgattagcga acacgcagtg ttcaatgttg atctgatgag caagaaaatt 120
catctgacgg agaacggcat tcgtgtcgac atcggtgaca ccatcatcta tttggttcac 180
taatgactcg ag                                                     192

<210> 110
<211> 1389
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 110
agcaaaagca ccggcaactt cctgaccctg acgcaagcga ttgacaaatt cagcgcggac 60
ggtatgcgtc tggctctggc ggatgcgggt gacacggtgg aagatgcgaa ttttgtggaa 120
gctatggcag atgccggtat tctgcgtctg tacacgtggg tggaatgggt gaaagagatg 180
gtcgctaact gggacagcct gcgcagcggt ccggctagca cctttaacga tcgcgtgttc 240
gcgtctgagc tgaacgcggg catcatcaaa accgatcaga attatgagaa aatgatgttt 300
aaagaagcac tgaaaacggg cttctttgaa ttccaagcgg cgaaagacaa atatcgtgaa 360
ctggcagtcg agggcatgca ccgtgagctg gttttccgct tcatcgaagt gcaaactctg 420
ctgctggcac cgttttgccc acacctgtgc gagcacatct ggaccctgct gggcaagccg 480
gattctatca tgaatgcgtc ctggccggtc gccggtccag ttaacgaagt gctgattcac 540
agcagccaat atctgatgga ggttacccac gacctgcgct tgcgtttgaa gaattatatg 600
atgccggcga agggtaagaa aactgataaa cagccgctgc aaaagccgag ccactgtacc 660
atttacgtgg ccaagaacta cccgccgtgg cagcacacga ccttgagcgt tctgcgtaaa 720
cattttgagg ccaacaacgg taaactgccg gataataaag ttatcgcatc ggaactgggt 780
agcatgccgg aactgaagaa gtacatgaag aaggtcatgc cgttcgtcgc gatgatcaaa 840
gaaaatctgg agaagatggg cccgcgtatt ctggatctgc agctggaatt cgacgaaaag 900
gcagttttga tggaaaacat cgtttacctg accaacagcc tggagttgga gcatatcgag 960
gttaagttcg cctccgaggc ggaggataag attcgcgagg actgctgtcc aggcaaaccg 1020
ctgaatgtgt ttcgtatcga gccgggtgtt agcgtcagct tggttaatcc gcaaccgtcc 1080
aacggtcatt tcagcacgaa gatcgagatc cgtcagggcg acaattgtga cagcattatt 1140
cgtcgcctga tgaagatgaa ccgtggtatt aaagatctga gcaaggtcaa actgatgcgt 1200
ttcgacgatc cgctgttggg tcctcgtcgt gtccctgttc tgggcaaaga gtacaccgag 1260
aaaaccccga tcagcgagca tgcagtgttt aatgttgacc tgatgtccaa gaagattcat 1320
ctgaccgaaa acggcattcg cgtggacatt ggtgacacga tcatttatct ggtccactaa 1380
tgactcgag                                                         1389

<210> 111
<211> 353
<212> PRT
<213> Homo sapiens

<400> 111
Glu Lys Met Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu Thr Gln Ala
 1               5                  10                  15      
Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu Ala Asp Ala
            20                  25                  30          
Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met Ala Asp Ala
        35                  40                  45              
Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys Glu Met Val
    50                  55                  60                  
Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr Phe Asn Asp
65                  70                  75                  80  
Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys Thr Asp Gln
                85                  90                  95      
Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe
            100                 105                 110         
Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala Val Glu Gly
        115                 120                 125             
Met His Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln Thr Leu Leu
    130                 135                 140                 
Leu Ala Pro Phe Cys Pro His Leu Cys Glu His Ile Trp Thr Leu Leu
145                 150                 155                 160 
Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val Ala Gly Pro
                165                 170                 175     
Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu Val Thr
            180                 185                 190         
His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala Lys Gly
        195                 200                 205             
Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys Thr Ile
    210                 215                 220                 
Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu Ser Val
225                 230                 235                 240 
Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys
                245                 250                 255     
Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys Tyr Met
            260                 265                 270         
Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu Glu Lys
        275                 280                 285             
Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu Lys Ala
    290                 295                 300                 
Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu Glu
305                 310                 315                 320 
His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile Arg Glu
                325                 330                 335     
Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu Pro Gly
            340                 345                 350         
Val
    


<210> 112
<211> 1059
<212> DNA
<213> Homo sapiens

<400> 112
gagaagatgt caaaatccac aggcaacttc ctcactttga cccaagctat tgacaaattt 60
tcagcagatg gaatgcgttt ggctctggct gatgctggtg acactgtaga agatgccaac 120
tttgtggaag ccatggcaga tgcaggtatt ctccgtctgt acacctgggt agagtgggtg 180
aaagaaatgg ttgccaactg ggacagccta agaagtggtc ctgccagcac tttcaatgat 240
agagtttttg ccagtgaatt gaatgcagga attataaaaa cagatcaaaa ctatgaaaag 300
atgatgttta aagaagcttt gaaaacaggg ttttttgagt ttcaggccgc aaaagataag 360
taccgtgaat tggctgtgga agggatgcac agagaacttg tgttccggtt tattgaagtt 420
cagacacttc tcctcgctcc attctgtcca catttgtgtg agcacatctg gacactcctg 480
ggaaagcctg actcaattat gaatgcttca tggcctgtgg caggtcctgt taatgaagtt 540
ttaatacact cctcacagta tcttatggaa gtaacacatg accttagact acgactcaag 600
aactatatga tgccagctaa agggaagaag actgacaaac aacccctgca gaagccctca 660
cattgcacca tctatgtggc aaagaactat ccaccttggc aacataccac cctgtctgtt 720
ctacgtaaac actttgaggc caataacgga aaactgcctg acaacaaagt cattgctagt 780
gaactaggca gtatgccaga actgaagaaa tacatgaaga aagtcatgcc atttgttgcc 840
atgattaagg aaaatctgga gaagatgggg cctcgtattc tggatttgca attagaattt 900
gatgaaaagg ctgtgcttat ggagaatata gtctatctga ctaattcgct tgagctagaa 960
cacatagaag tcaagtttgc ctccgaagca gaagataaaa tcagggaaga ctgctgtcct 1020
gggaaaccac ttaatgtttt tagaatagaa cctggtgtg                        1059

<210> 113
<211> 26
<212> PRT
<213> Mus musculus

<400> 113
Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val
 1               5                  10                  15      
Glu Ala Met Ala Asp Ala Gly Ile Leu Arg
            20                  25      


<210> 114
<211> 29
<212> PRT
<213> Mus musculus

<400> 114
Leu Tyr Thr Trp Val Glu Trp Val Lys Glu Met Leu Ala Ser Cys Ser
 1               5                  10                  15      
Ser Leu Arg Ser Gly Pro Ala Asp Ser Phe Asn Asp Arg
            20                  25                  


<210> 115
<211> 12
<212> PRT
<213> Mus musculus

<400> 115
Val Phe Ala Ser Glu Met Asn Ala Gly Ile Ile Lys
 1               5                  10          


<210> 116
<211> 67
<212> PRT
<213> Mus musculus

<400> 116
Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val
 1               5                  10                  15      
Glu Ala Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu
            20                  25                  30          
Trp Val Lys Glu Met Leu Ala Ser Cys Ser Ser Leu Arg Ser Gly Pro
        35                  40                  45              
Ala Asp Ser Phe Asn Asp Arg Val Phe Ala Ser Glu Met Asn Ala Gly
    50                  55                  60                  
Ile Ile Lys
65          


<210> 117
<211> 74
<212> PRT
<213> Homo sapiens

<400> 117
Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe
 1               5                  10                  15      
Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn
            20                  25                  30          
Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn
        35                  40                  45              
Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr
    50                  55                  60                  
Gln Gly Phe Thr Lys Asp Asn Gly Val Val
65                  70                  


<210> 118
<211> 222
<212> DNA
<213> Homo sapiens

<400> 118
gagccatacc catctaaatt aagtggcctg aaaggtaaaa atattttctt ggtggctgct 60
actctcagac ctgagaccat gtttgggcag acaaattgtt gggttcgtcc tgatatgaag 120
tacattggat ttgagacggt gaatggtgat atattcatct gtacccaaaa agcagccagg 180
aatatgtcat accagggctt taccaaagac aatggcgtgg tg                    222

<210> 119
<211> 125
<212> PRT
<213> Homo sapiens

<400> 119
Lys Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met
 1               5                  10                  15      
Pro Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr
            20                  25                  30          
Gly Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr
        35                  40                  45              
Ser Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys
    50                  55                  60                  
Lys Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly
65                  70                  75                  80  
Ile Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser
                85                  90                  95      
Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp
            100                 105                 110         
Leu Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser
        115                 120                 125 


<210> 120
<211> 375
<212> DNA
<213> Homo sapiens

<400> 120
aaaggaaaat gttgtctgtt tccctttggc ctgcactgta ctggaatgcc tattaaggca 60
tgtgctgata agttgaaaag agaaatagag ctgtatggtt gcccccctga ttttccagat 120
gaagaagagg aagaggaaga aaccagtgtt aaaacagaag atataataat taaggataaa 180
gctaaaggaa aaaagagtaa agctgctgct aaagctggat cttctaaata ccagtggggc 240
attatgaaat cccttggcct gtctgatgaa gagatagtaa aattttctga agcagaacat 300
tggcttgatt atttcccgcc actggctatt caggatttaa aaagaatggg tttgaaggta 360
gactggcgtc gttcc                                                  375

<210> 121
<211> 374
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 121
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Glu Lys Met Ser Lys Ser Thr Gly Asn Phe Leu
            20                  25                  30          
Thr Leu Thr Gln Ala Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu
        35                  40                  45              
Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu
    50                  55                  60                  
Ala Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp
65                  70                  75                  80  
Val Lys Glu Met Val Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala
                85                  90                  95      
Ser Thr Phe Asn Asp Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile
            100                 105                 110         
Ile Lys Thr Asp Gln Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu
        115                 120                 125             
Lys Thr Gly Phe Phe Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu
    130                 135                 140                 
Leu Ala Val Glu Gly Met His Arg Glu Leu Val Phe Arg Phe Ile Glu
145                 150                 155                 160 
Val Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro His Leu Cys Glu His
                165                 170                 175     
Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp
            180                 185                 190         
Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr
        195                 200                 205             
Leu Met Glu Val Thr His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met
    210                 215                 220                 
Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro
225                 230                 235                 240 
Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His
                245                 250                 255     
Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys
            260                 265                 270         
Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu
        275                 280                 285             
Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys
    290                 295                 300                 
Glu Asn Leu Glu Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu
305                 310                 315                 320 
Phe Asp Glu Lys Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn
                325                 330                 335     
Ser Leu Glu Leu Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu
            340                 345                 350         
Asp Lys Ile Arg Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe
        355                 360                 365             
Arg Ile Glu Pro Gly Val
    370                 


<210> 122
<211> 374
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 122
Met Glu Lys Met Ser Lys Ser Thr Gly Asn Phe Leu Thr Leu Thr Gln
 1               5                  10                  15      
Ala Ile Asp Lys Phe Ser Ala Asp Gly Met Arg Leu Ala Leu Ala Asp
            20                  25                  30          
Ala Gly Asp Thr Val Glu Asp Ala Asn Phe Val Glu Ala Met Ala Asp
        35                  40                  45              
Ala Gly Ile Leu Arg Leu Tyr Thr Trp Val Glu Trp Val Lys Glu Met
    50                  55                  60                  
Val Ala Asn Trp Asp Ser Leu Arg Ser Gly Pro Ala Ser Thr Phe Asn
65                  70                  75                  80  
Asp Arg Val Phe Ala Ser Glu Leu Asn Ala Gly Ile Ile Lys Thr Asp
                85                  90                  95      
Gln Asn Tyr Glu Lys Met Met Phe Lys Glu Ala Leu Lys Thr Gly Phe
            100                 105                 110         
Phe Glu Phe Gln Ala Ala Lys Asp Lys Tyr Arg Glu Leu Ala Val Glu
        115                 120                 125             
Gly Met His Arg Glu Leu Val Phe Arg Phe Ile Glu Val Gln Thr Leu
    130                 135                 140                 
Leu Leu Ala Pro Phe Cys Pro His Leu Cys Glu His Ile Trp Thr Leu
145                 150                 155                 160 
Leu Gly Lys Pro Asp Ser Ile Met Asn Ala Ser Trp Pro Val Ala Gly
                165                 170                 175     
Pro Val Asn Glu Val Leu Ile His Ser Ser Gln Tyr Leu Met Glu Val
            180                 185                 190         
Thr His Asp Leu Arg Leu Arg Leu Lys Asn Tyr Met Met Pro Ala Lys
        195                 200                 205             
Gly Lys Lys Thr Asp Lys Gln Pro Leu Gln Lys Pro Ser His Cys Thr
    210                 215                 220                 
Ile Tyr Val Ala Lys Asn Tyr Pro Pro Trp Gln His Thr Thr Leu Ser
225                 230                 235                 240 
Val Leu Arg Lys His Phe Glu Ala Asn Asn Gly Lys Leu Pro Asp Asn
                245                 250                 255     
Lys Val Ile Ala Ser Glu Leu Gly Ser Met Pro Glu Leu Lys Lys Tyr
            260                 265                 270         
Met Lys Lys Val Met Pro Phe Val Ala Met Ile Lys Glu Asn Leu Glu
        275                 280                 285             
Lys Met Gly Pro Arg Ile Leu Asp Leu Gln Leu Glu Phe Asp Glu Lys
    290                 295                 300                 
Ala Val Leu Met Glu Asn Ile Val Tyr Leu Thr Asn Ser Leu Glu Leu
305                 310                 315                 320 
Glu His Ile Glu Val Lys Phe Ala Ser Glu Ala Glu Asp Lys Ile Arg
                325                 330                 335     
Glu Asp Cys Cys Pro Gly Lys Pro Leu Asn Val Phe Arg Ile Glu Pro
            340                 345                 350         
Gly Val Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
        355                 360                 365             
His His His His His His
    370                 


<210> 123
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 123
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys
            20                  25                  30          
Gly Lys Asn Ile Phe Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met
        35                  40                  45              
Phe Gly Gln Thr Asn Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly
    50                  55                  60                  
Phe Glu Thr Val Asn Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala
65                  70                  75                  80  
Arg Asn Met Ser Tyr Gln Gly Phe Thr Lys Asp Asn Gly Val Val
                85                  90                  95  


<210> 124
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 124
Met Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile
 1               5                  10                  15      
Phe Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr
            20                  25                  30          
Asn Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val
        35                  40                  45              
Asn Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser
    50                  55                  60                  
Tyr Gln Gly Phe Thr Lys Asp Asn Gly Val Val Gly Lys Pro Ile Pro
65                  70                  75                  80  
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                85                  90                  95  


<210> 125
<211> 146
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 125
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Lys Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu
            20                  25                  30          
His Cys Thr Gly Met Pro Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg
        35                  40                  45              
Glu Ile Glu Leu Tyr Gly Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu
    50                  55                  60                  
Glu Glu Glu Glu Thr Ser Val Lys Thr Glu Asp Ile Ile Ile Lys Asp
65                  70                  75                  80  
Lys Ala Lys Gly Lys Lys Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser
                85                  90                  95      
Lys Tyr Gln Trp Gly Ile Met Lys Ser Leu Gly Leu Ser Asp Glu Glu
            100                 105                 110         
Ile Val Lys Phe Ser Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro
        115                 120                 125             
Leu Ala Ile Gln Asp Leu Lys Arg Met Gly Leu Lys Val Asp Trp Arg
    130                 135                 140                 
Arg Ser
145     


<210> 126
<211> 146
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leucyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 126
Met Lys Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly
 1               5                  10                  15      
Met Pro Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu
            20                  25                  30          
Tyr Gly Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu
        35                  40                  45              
Thr Ser Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly
    50                  55                  60                  
Lys Lys Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp
65                  70                  75                  80  
Gly Ile Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe
                85                  90                  95      
Ser Glu Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln
            100                 105                 110         
Asp Leu Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Gly Lys
        115                 120                 125             
Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His
    130                 135                 140                 
His His
145     


<210> 127
<211> 1071
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 127
gagaaaatga gcaaaagcac cggcaacttc ctgaccctga cgcaggctat tgataaattt 60
agcgcagatg gcatgcgtct ggccttggcc gacgcgggtg acacggtgga ggacgcgaac 120
ttcgtcgagg ctatggctga tgcaggcatt ctgcgtctgt acacctgggt ggaatgggtc 180
aaagaaatgg tggccaactg ggatagcctg cgcagcggtc cggctagcac ttttaacgac 240
cgtgtgtttg cgtccgagct gaacgcaggt attatcaaaa cggaccagaa ttacgagaaa 300
atgatgttca aagaagcgct gaaaacgggc ttcttcgagt ttcaagcggc caaagataag 360
tatcgtgagc tggccgtcga gggtatgcac cgcgagctgg tgtttcgttt cattgaagtc 420
cagaccttgc tgctggcgcc gttttgccca catctgtgtg aacacatttg gaccctgctg 480
ggtaaaccag acagcatcat gaacgcaagc tggcctgtcg caggcccggt gaatgaggtt 540
ttgattcata gctcccaata tctgatggaa gtgacccacg atctgcgcct gcgtttgaag 600
aattatatga tgccggcgaa gggcaagaaa acggacaaac agccgctgca gaagccgagc 660
cactgcacca tctacgttgc caagaattac ccgccgtggc aacacacgac cctgtccgtg 720
ctgcgtaagc attttgaagc aaacaatggt aagctgccgg acaataaagt cattgcaagc 780
gagctgggtt ctatgccgga actgaagaag tatatgaaga aagtgatgcc gttcgttgcg 840
atgatcaaag agaacctgga aaagatgggt ccgcgcattc tggacctgca actggaattc 900
gatgagaaag cggttctgat ggagaatatc gtttacttga ccaacagcct ggagttggag 960
cacatcgagg ttaaattcgc gtcggaagcg gaagataaga tccgtgagga ctgttgcccg 1020
ggtaagccgc tgaacgtttt ccgcatcgaa cctggcgttt aatgactcga g          1071

<210> 128
<211> 234
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 128
gagccatacc caagcaaact gagcggcctg aagggcaaaa acatcttcct ggtggctgcc 60
accctgcgcc cggagactat gttcggtcaa acgaactgct gggttcgtcc ggacatgaaa 120
tacattggtt ttgaaacggt taatggtgat atctttattt gtacccagaa agcggcacgt 180
aacatgagct atcagggctt taccaaggac aatggcgtgg tctaatgact cgag       234

<210> 129
<211> 387
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized leucyl tRNA Synthetase
      polynucleotide

<400> 129
aaaggtaaat gctgtctgtt cccgttcggc ctgcactgca ccggtatgcc gatcaaagcc 60
tgtgctgaca aactgaagcg cgagatcgag ctgtacggct gcccgccgga cttcccagat 120
gaagaagaag aagaagaaga aaccagcgtg aaaacggagg acattatcat taaagacaag 180
gccaaaggta agaaatctaa ggcggcagcg aaagcgggta gcagcaaata tcagtggggc 240
attatgaaga gcctgggctt gtccgatgaa gagattgtca agtttagcga ggcggagcac 300
tggctggatt acttcccgcc gctggcaatc caagatctga agcgtatggg tctgaaggtt 360
gactggcgtc gtagctaatg actcgag                                     387
