                         SEQUENCE LISTING

<110>  XL-protein GmbH
       Technische Universitt Mnchen
       SKERRA, Arne
       BINDER, Uli
       SCHLAPSCHY, Martin
 
<120>  Biosynthetic proline/alanine random coil polypeptides  and their 
       uses

<130>  S1467 PCT S3

<160>  61    

<170>  PatentIn version 3.3

<210>  1
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       PA#1"

<400>  1

Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ala 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       PA#2"

<400>  2

Ala Ala Pro Ala Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
1               5                   10                  15      


Pro Ala Ala Pro 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       PA#3"

<400>  3

Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Pro 
            20  


<210>  4
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       PA#4"

<400>  4

Ala Ala Pro Ala Ala Pro Ala Ala Pro Ala Ala Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Pro Ala Ala Pro Ala Ala Pro 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       PA#5"

<400>  5

Ala Pro Ala Ala Ala Pro Ala Pro Ala Ala Ala Pro Ala Pro Ala Ala 
1               5                   10                  15      


Ala Pro Ala Pro Ala Ala Ala Pro 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       PA#6"

<400>  6

Ala Ala Ala Pro Ala Ala Pro Ala Ala Pro Pro Ala Ala Ala Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ala Ala Pro Pro Ala 
            20                  


<210>  7
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  7

Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10                  15      


Ala Pro Ala Ala 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  8

Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala 
1               5                   10                  15      


Pro Ala Ala Ala 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  9

Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Pro 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  10

Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Ala Pro Ala 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  11

Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
1               5                   10                  15      


Ala Pro Ala Ala 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  12

Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala 
1               5                   10                  15      


Pro Ala Ala Pro 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  13

Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ala 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  14

Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  15

Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala 
1               5                   10                  15      


Pro Ala Pro Ala 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a circular permutated version of SEQ ID NO: 1"

<400>  16

Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro 
1               5                   10                  15      


Ala Pro Ala Ala 
            20  


<210>  17
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of  the upper/coding strand oligodeoxynucleotide used for the 
       generation of building block PA#1"

<400>  17
gccgctccag ctgcacctgc tccagcagca cctgctgcac cagctccggc tgctcctgct     60


<210>  18
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of lower/non-coding strand oligodeoxynucleotide used for the 
       generation of the building block for PA#1"

<400>  18
ggcagcagga gcagccggag ctggtgcagc aggtgctgct ggagcaggtg cagctggagc     60


<210>  19
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (upper/coding strand) around the C-terminus of the 
       immunoglobulin light chain of an antibody Fab fragment as encoded
       on pASK88-Fab-2xSapI"

<400>  19
aagagcttca accgcggaga gtgctcttct gcctgaagag cttaagctt                 49


<210>  20
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (lower/non-coding strand) around the C-terminus of the 
       immunoglobulin light chain of an antibody Fab fragment as encoded
       on pASK88-Fab-2xSapI"

<400>  20
aagcttaagc tcttcaggca gaagagcact ctccgcggtt gaagctctt                 49


<210>  21
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       the C-terminus of the light chain of the Fab fragment as encoded 
       on pASK88-Fab-2xSapI"

<400>  21

Lys Ser Phe Asn Arg Gly Glu Cys Ser Ser Ala 
1               5                   10      


<210>  22
<211>  4610
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pASK88-Fab-2xSapI"

<400>  22
acccgacacc atcgaatggc cagatgatta attcctaatt tttgttgaca ctctatcatt     60

gatagagtta ttttaccact ccctatcagt gatagagaaa agtgaaatga atagttcgac    120

aaaaatctag ataacgaggg caaaaaatga aaaagacagc tatcgcgatt gcagtggcac    180

tggctggttt cgctaccgta gcgcaggccg aagttaaact gcaggaatcc ggtggtggtc    240

tggttcagcc aggtggttcc ctgcggctct cgtgtgctgc ttccggtttc aacatcaaag    300

acacctacat ccactgggtt cgtcaggctc cgggtaaagg cctggaatgg gttgctcgta    360

tctacccgac caacggttac accaggtatg ccgattcagt taaaggtcgt ttcaccatct    420

cggccgacac ttccaaaaac accgcttacc tccagatgaa ctccctgcgt gctgaagaca    480

cagctgttta ttattgctcc cgttggggtg gtgacggttt ctacgctatg gactactggg    540

gtcagggtac cctggtcacc gtctcctcag cctccaccaa gggcccatcg gtcttccccc    600

tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc ctggtcaagg    660

actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc    720

acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgactg    780

tgccctccag cagcttgggc acccagacct acatctgcaa cgttaatcac aaacccagca    840

acaccaaggt cgacaagaaa gttgagccca aatcttgcca tcaccaccat caccattaat    900

aaccatggag aaaataaagt gaaacaaagc actattgcac tggcactctt accgttactg    960

tttacccctg tgacaaaagc cgacatcgag ctcacccaat ccccgtcctc cctgtccgct   1020

tccgttggcg accgtgttac catcacgtgt agggcctcgc aagacgtaaa caccgccgta   1080

gcgtggtatc agcagaaacc cgggaaagct ccgaaactgc tgatctatag cgcttccttc   1140

ctgtattccg gagttccgag caggttcagt ggttcccgtt ccggtaccga cttcaccctg   1200

acgatatcct ccctccagcc ggaagacttc gctacctact actgtcaaca gcactacacc   1260

accccgccga ccttcggtca gggtaccaaa ctcgagatca aacggactgt ggctgcacca   1320

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg   1380

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc   1440

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac   1500

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc   1560

tgcgaagtca cccatcaggg cctgagttcg cccgtcacaa agagcttcaa ccgcggagag   1620

tgctcttctg cctgaagagc ttaagcttga cctgtgaagt gaaaaatggc gcacattgtg   1680

cgacattttt tttgtctgcc gtttaccgct actgcgtcac ggatctccac gcgccctgta   1740

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca   1800

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct   1860

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc   1920

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat   1980

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc   2040

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc   2100

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta   2160

acaaaatatt aacgtttaca atttcaggtg gcacttttcg gggaaatgtg cgcggaaccc   2220

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct   2280

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg   2340

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg   2400

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc   2460

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca   2520

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac   2580

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa   2640

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg   2700

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt   2760

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg   2820

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc   2880

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaattg atagactgga   2940

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta   3000

ttgctgataa atctggagcc ggtgagcgtg gctctcgcgg tatcattgca gcactggggc   3060

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg   3120

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaggaat   3180

taatgatgtc tcgtttagat aaaagtaaag tgattaacag cgcattagag ctgcttaatg   3240

aggtcggaat cgaaggttta acaacccgta aactcgccca gaagctaggt gtagagcagc   3300

ctacattgta ttggcatgta aaaaataagc gggctttgct cgacgcctta gccattgaga   3360

tgttagatag gcaccatact cacttttgcc ctttagaagg ggaaagctgg caagattttt   3420

tacgtaataa cgctaaaagt tttagatgtg ctttactaag tcatcgcgat ggagcaaaag   3480

tacatttagg tacacggcct acagaaaaac agtatgaaac tctcgaaaat caattagcct   3540

ttttatgcca acaaggtttt tcactagaga atgcattata tgcactcagc gcagtggggc   3600

attttacttt aggttgcgta ttggaagatc aagagcatca agtcgctaaa gaagaaaggg   3660

aaacacctac tactgatagt atgccgccat tattacgaca agctatcgaa ttatttgatc   3720

accaaggtgc agagccagcc ttcttattcg gccttgaatt gatcatatgc ggattagaaa   3780

aacaacttaa atgtgaaagt gggtcttaaa agcagcataa cctttttccg tgatggtaac   3840

ttcactagtt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc   3900

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt   3960

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac   4020

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct   4080

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact   4140

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg   4200

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata   4260

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga   4320

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag   4380

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg   4440

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac   4500

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca   4560

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg              4610


<210>  23
<211>  85
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (upper/coding strand) encoding amino acid sequence of the
       C-terminus of the Fab light chain after insertion of one PA#1(20)
       polymer"

<400>  23
gagtgctctt ctgccgctcc agctgcacct gctccagcag cacctgctgc accagctccg     60

gctgctcctg ctgcctgaag agctt                                           85


<210>  24
<211>  85
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       (lower/non-coding strand) for an amino acid stretch of the 
       C-terminus of an Fab light chain after insertion of one PA#1(20) 
       polymer"

<400>  24
aagctcttca ggcagcagga gcagccggag ctggtgcagc aggtgctgct ggagcaggtg     60

cagctggagc ggcagaagag cactc                                           85


<210>  25
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence 
       stretch of the C-terminus of an Fab light chain after insertion 
       of one PA#1(20) polymer"

<400>  25

Glu Cys Ser Ser Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Pro Ala Pro Ala Ala Pro Ala Ala 
            20                  25  


<210>  26
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       a Fab heavy chain as encoded on pFab-PA#1(200)"

<400>  26

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys His 
    210                 215                 220                 


His His His His His 
225                 


<210>  27
<211>  417
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       the Fab light chain fused with the PA#1(200) polymer as encoded 
       on pFab-PA#1(200)"

<400>  27

Asp Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Ser Ala Ala Pro Ala Ala Pro Ala Pro 
    210                 215                 220                 


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
225                 230                 235                 240 


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
                245                 250                 255     


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
            260                 265                 270         


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
        275                 280                 285             


Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro 
    290                 295                 300                 


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
                325                 330                 335     


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
            340                 345                 350         


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
        355                 360                 365             


Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro 
    370                 375                 380                 


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
385                 390                 395                 400 


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
                405                 410                 415     


Ala 
    


<210>  28
<211>  5210
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pFab-PA#1(200)"

<400>  28
acccgacacc atcgaatggc cagatgatta attcctaatt tttgttgaca ctctatcatt     60

gatagagtta ttttaccact ccctatcagt gatagagaaa agtgaaatga atagttcgac    120

aaaaatctag ataacgaggg caaaaaatga aaaagacagc tatcgcgatt gcagtggcac    180

tggctggttt cgctaccgta gcgcaggccg aagttaaact gcaggaatcc ggtggtggtc    240

tggttcagcc aggtggttcc ctgcggctct cgtgtgctgc ttccggtttc aacatcaaag    300

acacctacat ccactgggtt cgtcaggctc cgggtaaagg cctggaatgg gttgctcgta    360

tctacccgac caacggttac accaggtatg ccgattcagt taaaggtcgt ttcaccatct    420

cggccgacac ttccaaaaac accgcttacc tccagatgaa ctccctgcgt gctgaagaca    480

cagctgttta ttattgctcc cgttggggtg gtgacggttt ctacgctatg gactactggg    540

gtcagggtac cctggtcacc gtctcctcag cctccaccaa gggcccatcg gtcttccccc    600

tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc ctggtcaagg    660

actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc    720

acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgactg    780

tgccctccag cagcttgggc acccagacct acatctgcaa cgttaatcac aaacccagca    840

acaccaaggt cgacaagaaa gttgagccca aatcttgcca tcaccaccat caccattaat    900

aaccatggag aaaataaagt gaaacaaagc actattgcac tggcactctt accgttactg    960

tttacccctg tgacaaaagc cgacatcgag ctcacccaat ccccgtcctc cctgtccgct   1020

tccgttggcg accgtgttac catcacgtgt agggcctcgc aagacgtaaa caccgccgta   1080

gcgtggtatc agcagaaacc cgggaaagct ccgaaactgc tgatctatag cgcttccttc   1140

ctgtattccg gagttccgag caggttcagt ggttcccgtt ccggtaccga cttcaccctg   1200

acgatatcct ccctccagcc ggaagacttc gctacctact actgtcaaca gcactacacc   1260

accccgccga ccttcggtca gggtaccaaa ctcgagatca aacggactgt ggctgcacca   1320

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg   1380

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc   1440

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac   1500

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc   1560

tgcgaagtca cccatcaggg cctgagttcg cccgtcacaa agagcttcaa ccgcggagag   1620

tgctcttctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   1680

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   1740

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   1800

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   1860

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   1920

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   1980

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   2040

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   2100

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   2160

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct   2220

gctcctgctg cctgaagagc ttaagcttga cctgtgaagt gaaaaatggc gcacattgtg   2280

cgacattttt tttgtctgcc gtttaccgct actgcgtcac ggatctccac gcgccctgta   2340

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca   2400

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct   2460

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc   2520

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat   2580

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc   2640

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc   2700

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta   2760

acaaaatatt aacgtttaca atttcaggtg gcacttttcg gggaaatgtg cgcggaaccc   2820

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct   2880

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg   2940

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg   3000

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc   3060

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca   3120

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac   3180

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa   3240

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg   3300

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt   3360

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg   3420

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc   3480

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaattg atagactgga   3540

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta   3600

ttgctgataa atctggagcc ggtgagcgtg gctctcgcgg tatcattgca gcactggggc   3660

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg   3720

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaggaat   3780

taatgatgtc tcgtttagat aaaagtaaag tgattaacag cgcattagag ctgcttaatg   3840

aggtcggaat cgaaggttta acaacccgta aactcgccca gaagctaggt gtagagcagc   3900

ctacattgta ttggcatgta aaaaataagc gggctttgct cgacgcctta gccattgaga   3960

tgttagatag gcaccatact cacttttgcc ctttagaagg ggaaagctgg caagattttt   4020

tacgtaataa cgctaaaagt tttagatgtg ctttactaag tcatcgcgat ggagcaaaag   4080

tacatttagg tacacggcct acagaaaaac agtatgaaac tctcgaaaat caattagcct   4140

ttttatgcca acaaggtttt tcactagaga atgcattata tgcactcagc gcagtggggc   4200

attttacttt aggttgcgta ttggaagatc aagagcatca agtcgctaaa gaagaaaggg   4260

aaacacctac tactgatagt atgccgccat tattacgaca agctatcgaa ttatttgatc   4320

accaaggtgc agagccagcc ttcttattcg gccttgaatt gatcatatgc ggattagaaa   4380

aacaacttaa atgtgaaagt gggtcttaaa agcagcataa cctttttccg tgatggtaac   4440

ttcactagtt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc   4500

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt   4560

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac   4620

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct   4680

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact   4740

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg   4800

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata   4860

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga   4920

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag   4980

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg   5040

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac   5100

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca   5160

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg              5210


<210>  29
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       (upper/coding strand) encoding amino acid sequence of the 
       N-terminus of INFa2b and Strep-tag II (only the last two amino 
       acids)"

<400>  29
gaaaaaggcg ccagctcttc tgcctgtgat ctgcctcaaa cccacagcct gggtagc        57


<210>  30
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       (lower/non-coding strand) encoding amino acid sequence of the 
       N-terminus of INFa2b and Strep-tag II (only the last two amino 
       acids)"

<400>  30
gctacccagg ctgtgggttt gaggcagatc acaggcagaa gagctggcgc ctttttc        57


<210>  31
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       the C-terminus of Strep-tag II and the N-terminus of INFa2b"

<400>  31

Glu Lys Gly Ala Ser Ser Ser Ala Cys Asp Leu Pro Gln Thr His Ser 
1               5                   10                  15      


Leu Gly Ser 
            


<210>  32
<211>  3721
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pASK-IFNa2b"

<400>  32
ccatcgaatg gccagatgat taattcctaa tttttgttga cactctatca ttgatagagt     60

tattttacca ctccctatca gtgatagaga aaagtgaaat gaatagttcg acaaaaatct    120

agataacgag ggcaaaaaat gaaaaagaca gctatcgcga ttgcagtggc actggctggt    180

ttcgctaccg tagcgcaggc cgctagctgg agccacccgc agttcgaaaa aggcgccagc    240

tcttctgcct gtgatctgcc tcaaacccac agcctgggta gcaggaggac cttgatgctc    300

ctggcacaga tgaggagaat ctctcttttc tcctgcttga aggacagaca tgactttgga    360

tttccccagg aggagtttgg caaccagttc caaaaggctg aaaccatccc tgtcctccat    420

gagatgatcc agcagatctt caatctcttc agcacaaagg actcatctgc tgcttgggat    480

gagaccctcc tagacaaatt ctacactgaa ctctaccagc agctgaatga cctggaagcc    540

tgtgtgatac agggggtggg ggtgacagag actcccctga tgaaggagga ctccattctg    600

gctgtgagga aatacttcca aagaatcact ctctatctga aagagaagaa atacagccct    660

tgtgcctggg aggttgtcag agcagaaatc atgagatctt tttctttgtc aacaaacttg    720

caagaaagtt taagaagtaa ggaataagct tgacctgtga agtgaaaaat ggcgcacatt    780

gtgcgacatt ttttttgtct gccgtttacc gctactgcgt cacggatctc cacgcgccct    840

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg    900

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg    960

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac   1020

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct   1080

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt   1140

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt   1200

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt   1260

ttaacaaaat attaacgctt acaatttcag gtggcacttt tcggggaaat gtgcgcggaa   1320

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac   1380

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg   1440

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc   1500

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg   1560

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga   1620

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc   1680

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag   1740

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga   1800

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg   1860

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga   1920

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt   1980

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttgatagact   2040

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt   2100

ttattgctga taaatctgga gccggtgagc gtggctctcg cggtatcatt gcagcactgg   2160

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta   2220

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtagg   2280

aattaatgat gtctcgttta gataaaagta aagtgattaa cagcgcatta gagctgctta   2340

atgaggtcgg aatcgaaggt ttaacaaccc gtaaactcgc ccagaagcta ggtgtagagc   2400

agcctacatt gtattggcat gtaaaaaata agcgggcttt gctcgacgcc ttagccattg   2460

agatgttaga taggcaccat actcactttt gccctttaga aggggaaagc tggcaagatt   2520

ttttacgtaa taacgctaaa agttttagat gtgctttact aagtcatcgc gatggagcaa   2580

aagtacattt aggtacacgg cctacagaaa aacagtatga aactctcgaa aatcaattag   2640

cctttttatg ccaacaaggt ttttcactag agaatgcatt atatgcactc agcgcagtgg   2700

ggcattttac tttaggttgc gtattggaag atcaagagca tcaagtcgct aaagaagaaa   2760

gggaaacacc tactactgat agtatgccgc cattattacg acaagctatc gaattatttg   2820

atcaccaagg tgcagagcca gccttcttat tcggccttga attgatcata tgcggattag   2880

aaaaacaact taaatgtgaa agtgggtctt aaaagcagca taaccttttt ccgtgatggt   2940

aacttcacta gtttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa   3000

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat   3060

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc   3120

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg   3180

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc   3240

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg   3300

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg   3360

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa   3420

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg   3480

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga   3540

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct   3600

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca   3660

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgacccgac   3720

a                                                                   3721


<210>  33
<211>  90
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (upper/coding strand) encoding the C-terminus of 
       Strep-tag II and the N-terminus of IFNa2b after insertion of one 
       PA#1 polymer sequence cassette"

<400>  33
gaaaaaggcg ccagctcttc tgccgctcca gctgcacctg ctccagcagc acctgctgca     60

ccagctccgg ctgctcctgc tgcctgtgat                                      90


<210>  34
<211>  90
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (lower/non-coding strand) of the C-terminus of Strep-tag 
       II and the N-terminus of IFNa2b after insertion of one PA#1 
       polymer sequence cassette"

<400>  34
atcacaggca gcaggagcag ccggagctgg tgcagcaggt gctgctggag caggtgcagc     60

tggagcggca gaagagctgg cgcctttttc                                      90


<210>  35
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence 
       stretch of the C-terminus of Strep-tag II and the N-terminus of 
       IFNa2b ater fusion with one PA#1 polymer cassette"

<400>  35

Glu Lys Gly Ala Ser Ser Ser Ala Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10                  15      


Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Cys Asp 
            20                  25                  30  


<210>  36
<211>  381
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       IFNa2b and Strep-tag II fused with the PA#1(200) polymer as 
       encoded on pPA#1(200)-IFNa2b"

<400>  36

Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Ser Ser Ser Ala 
1               5                   10                  15      


Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
            20                  25                  30          


Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala 
    50                  55                  60                  


Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
                85                  90                  95      


Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
            100                 105                 110         


Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
        115                 120                 125             


Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala 
    130                 135                 140                 


Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala 
145                 150                 155                 160 


Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
                165                 170                 175     


Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
            180                 185                 190         


Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
        195                 200                 205             


Pro Ala Pro Ala Ala Pro Ala Ala Cys Asp Leu Pro Gln Thr His Ser 
    210                 215                 220                 


Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile 
225                 230                 235                 240 


Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln 
                245                 250                 255     


Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu 
            260                 265                 270         


His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser 
        275                 280                 285             


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
    290                 295                 300                 


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly 
305                 310                 315                 320 


Val Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg 
                325                 330                 335     


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser 
            340                 345                 350         


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
        355                 360                 365             


Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
    370                 375                 380     


<210>  37
<211>  4321
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pPA#1(200)-IFNa2b"

<400>  37
ccatcgaatg gccagatgat taattcctaa tttttgttga cactctatca ttgatagagt     60

tattttacca ctccctatca gtgatagaga aaagtgaaat gaatagttcg acaaaaatct    120

agataacgag ggcaaaaaat gaaaaagaca gctatcgcga ttgcagtggc actggctggt    180

ttcgctaccg tagcgcaggc cgctagctgg agccacccgc agttcgaaaa aggcgccagc    240

tcttctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    300

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    360

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    420

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    480

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    540

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    600

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    660

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    720

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    780

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct    840

cctgctgcct gtgatctgcc tcaaacccac agcctgggta gcaggaggac cttgatgctc    900

ctggcacaga tgaggagaat ctctcttttc tcctgcttga aggacagaca tgactttgga    960

tttccccagg aggagtttgg caaccagttc caaaaggctg aaaccatccc tgtcctccat   1020

gagatgatcc agcagatctt caatctcttc agcacaaagg actcatctgc tgcttgggat   1080

gagaccctcc tagacaaatt ctacactgaa ctctaccagc agctgaatga cctggaagcc   1140

tgtgtgatac agggggtggg ggtgacagag actcccctga tgaaggagga ctccattctg   1200

gctgtgagga aatacttcca aagaatcact ctctatctga aagagaagaa atacagccct   1260

tgtgcctggg aggttgtcag agcagaaatc atgagatctt tttctttgtc aacaaacttg   1320

caagaaagtt taagaagtaa ggaataagct tgacctgtga agtgaaaaat ggcgcacatt   1380

gtgcgacatt ttttttgtct gccgtttacc gctactgcgt cacggatctc cacgcgccct   1440

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg   1500

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg   1560

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac   1620

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct   1680

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt   1740

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt   1800

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt   1860

ttaacaaaat attaacgctt acaatttcag gtggcacttt tcggggaaat gtgcgcggaa   1920

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac   1980

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg   2040

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc   2100

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg   2160

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga   2220

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc   2280

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag   2340

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga   2400

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg   2460

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga   2520

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt   2580

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttgatagact   2640

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt   2700

ttattgctga taaatctgga gccggtgagc gtggctctcg cggtatcatt gcagcactgg   2760

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta   2820

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtagg   2880

aattaatgat gtctcgttta gataaaagta aagtgattaa cagcgcatta gagctgctta   2940

atgaggtcgg aatcgaaggt ttaacaaccc gtaaactcgc ccagaagcta ggtgtagagc   3000

agcctacatt gtattggcat gtaaaaaata agcgggcttt gctcgacgcc ttagccattg   3060

agatgttaga taggcaccat actcactttt gccctttaga aggggaaagc tggcaagatt   3120

ttttacgtaa taacgctaaa agttttagat gtgctttact aagtcatcgc gatggagcaa   3180

aagtacattt aggtacacgg cctacagaaa aacagtatga aactctcgaa aatcaattag   3240

cctttttatg ccaacaaggt ttttcactag agaatgcatt atatgcactc agcgcagtgg   3300

ggcattttac tttaggttgc gtattggaag atcaagagca tcaagtcgct aaagaagaaa   3360

gggaaacacc tactactgat agtatgccgc cattattacg acaagctatc gaattatttg   3420

atcaccaagg tgcagagcca gccttcttat tcggccttga attgatcata tgcggattag   3480

aaaaacaact taaatgtgaa agtgggtctt aaaagcagca taaccttttt ccgtgatggt   3540

aacttcacta gtttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa   3600

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat   3660

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc   3720

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg   3780

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc   3840

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg   3900

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg   3960

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa   4020

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg   4080

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga   4140

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct   4200

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca   4260

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgacccgac   4320

a                                                                   4321


<210>  38
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (upper/ coding strand) on pASK75-His6-hGH encoding the 
       amino acid sequence around the N-terminus of His6-hGH"

<400>  38
gccgctagcc atcaccacca tcaccatggc gccagctctt ctgccttccc aacc           54


<210>  39
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       stretch (lower/non-coding strand) on pASK75-His6-hGH encoding the
       amino acid sequence around the N-terminus of hGH"

<400>  39
ggttgggaag gcagaagagc tggcgccatg gtgatggtgg tgatggctag cggc           54


<210>  40
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence 
       stretch of the N-terminus of His6-hGH as encoded on 
       pASK75-His6-hGH"

<400>  40

Ala Ala Ser His His His His His His Gly Ala Ser Ser Ser Ala Phe 
1               5                   10                  15      


Pro Thr 
        


<210>  41
<211>  3793
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pASK75-His6-hGH"

<400>  41
acccgacacc atcgaatggc cagatgatta attcctaatt tttgttgaca ctctatcatt     60

gatagagtta ttttaccact ccctatcagt gatagagaaa agtgaaatga atagttcgac    120

aaaaatctag ataacgaggg caaaaaatga aaaagacagc tatcgcgatt gcagtggcac    180

tggctggttt cgctaccgta gcgcaggccg ctagccatca ccaccatcac catggcgcca    240

gctcttctgc cttcccaacc attcccttat ccaggctttt tgacaacgct atgctccgcg    300

cccatcgtct gcaccagctg gcctttgaca cctaccagga gtttgaagaa gcctatatcc    360

caaaggaaca gaagtattca ttcctgcaga acccccagac ctccctctgt ttctcagagt    420

ctattccgac accctccaac agggaggaaa cacaacagaa atccaaccta gagctgctcc    480

gcatctccct gctgctcatc cagtcgtggc tggagcccgt gcagttcctc aggagtgtct    540

tcgccaacag cctggtgtac ggcgcctctg acagcaacgt ctatgacctc ctaaaggacc    600

tagaggaagg catccaaacg ctgatgggga ggctggaaga tggcagcccc cggactgggc    660

agatcttcaa gcagacctac agcaagttcg acacaaactc acacaacgat gacgcactac    720

tcaagaacta cgggctgctc tactgcttca ggaaggacat ggacaaggtc gagacattcc    780

tgcgcatcgt gcagtgccgc tctgtggagg gcagctgtgg cttctaagct tgacctgtga    840

agtgaaaaat ggcgcacatt gtgcgacatt ttttttgtct gccgtttacc gctactgcgt    900

cacggatctc cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg    960

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc   1020

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg   1080

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc   1140

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt   1200

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc   1260

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta   1320

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt   1380

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta   1440

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat   1500

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt   1560

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg   1620

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga   1680

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg   1740

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt   1800

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg   1860

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg   1920

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga   1980

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc   2040

tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc   2100

ccggcaacaa ttgatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc   2160

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtggctctcg   2220

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac   2280

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc   2340

actgattaag cattggtagg aattaatgat gtctcgttta gataaaagta aagtgattaa   2400

cagcgcatta gagctgctta atgaggtcgg aatcgaaggt ttaacaaccc gtaaactcgc   2460

ccagaagcta ggtgtagagc agcctacatt gtattggcat gtaaaaaata agcgggcttt   2520

gctcgacgcc ttagccattg agatgttaga taggcaccat actcactttt gccctttaga   2580

aggggaaagc tggcaagatt ttttacgtaa taacgctaaa agttttagat gtgctttact   2640

aagtcatcgc gatggagcaa aagtacattt aggtacacgg cctacagaaa aacagtatga   2700

aactctcgaa aatcaattag cctttttatg ccaacaaggt ttttcactag agaatgcatt   2760

atatgcactc agcgcagtgg ggcattttac tttaggttgc gtattggaag atcaagagca   2820

tcaagtcgct aaagaagaaa gggaaacacc tactactgat agtatgccgc cattattacg   2880

acaagctatc gaattatttg atcaccaagg tgcagagcca gccttcttat tcggccttga   2940

attgatcata tgcggattag aaaaacaact taaatgtgaa agtgggtctt aaaagcagca   3000

taaccttttt ccgtgatggt aacttcacta gtttaaaagg atctaggtga agatcctttt   3060

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc   3120

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt   3180

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac   3240

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt   3300

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct   3360

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga   3420

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac   3480

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg   3540

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt   3600

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc   3660

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg   3720

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc   3780

ttttgctcac atg                                                      3793


<210>  42
<211>  114
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       (upper/coding-strand) stretch encoding amino acid sequence of the
       N-terminus of His6-hGH after insertion of the PA#1(20) polymer"

<400>  42
gccgctagcc atcaccacca tcaccatggc gccagctctt ctgccgctcc agctgcacct     60

gctccagcag cacctgctgc accagctccg gctgctcctg ctgccttccc aacc          114


<210>  43
<211>  114
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       (lower/non-coding strand) encoding the N-terminus of hGH after 
       insertion of one PA#1 polymer sequence cassette"

<400>  43
ggttgggaag gcagcaggag cagccggagc tggtgcagca ggtgctgctg gagcaggtgc     60

agctggagcg gcagaagagc tggcgccatg gtgatggtgg tgatggctag cggc          114


<210>  44
<211>  38
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       the N-terminus of His6-hGH after insertion of the PA#1(20) 
       polymer"

<400>  44

Ala Ala Ser His His His His His His Gly Ala Ser Ser Ser Ala Ala 
1               5                   10                  15      


Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala 
            20                  25                  30          


Pro Ala Ala Phe Pro Thr 
        35              


<210>  45
<211>  405
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       mature His6-PA#1(200)-hGH as encoded on 
       pASK75-His6-PA#1(200)-hGH"

<400>  45

Ala Ser His His His His His His Gly Ala Ser Ser Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
            20                  25                  30          


Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
        35                  40                  45              


Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
    50                  55                  60                  


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
65                  70                  75                  80  


Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
                85                  90                  95      


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
            100                 105                 110         


Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
        115                 120                 125             


Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
    130                 135                 140                 


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
145                 150                 155                 160 


Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
                165                 170                 175     


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
            180                 185                 190         


Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
        195                 200                 205             


Pro Ala Ala Pro Ala Ala Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe 
    210                 215                 220                 


Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp 
225                 230                 235                 240 


Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr 
                245                 250                 255     


Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile 
            260                 265                 270         


Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu 
        275                 280                 285             


Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val 
    290                 295                 300                 


Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser 
305                 310                 315                 320 


Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln 
                325                 330                 335     


Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile 
            340                 345                 350         


Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp 
        355                 360                 365             


Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met 
    370                 375                 380                 


Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu 
385                 390                 395                 400 


Gly Ser Cys Gly Phe 
                405 


<210>  46
<211>  4393
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pASK75-His6-PA#1(200)-hGH"

<400>  46
gacccgacac catcgaatgg ccagatgatt aattcctaat ttttgttgac actctatcat     60

tgatagagtt attttaccac tccctatcag tgatagagaa aagtgaaatg aatagttcga    120

caaaaatcta gataacgagg gcaaaaaatg aaaaagacag ctatcgcgat tgcagtggca    180

ctggctggtt tcgctaccgt agcgcaggcc gctagccatc accaccatca ccatggcgcc    240

agctcttctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    300

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    360

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    420

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    480

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    540

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    600

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    660

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    720

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    780

gctcctgctg ccgctccagc tgcacctgct ccagcagcac ctgctgcacc agctccggct    840

gctcctgctg ccttcccaac cattccctta tccaggcttt ttgacaacgc tatgctccgc    900

gcccatcgtc tgcaccagct ggcctttgac acctaccagg agtttgaaga agcctatatc    960

ccaaaggaac agaagtattc attcctgcag aacccccaga cctccctctg tttctcagag   1020

tctattccga caccctccaa cagggaggaa acacaacaga aatccaacct agagctgctc   1080

cgcatctccc tgctgctcat ccagtcgtgg ctggagcccg tgcagttcct caggagtgtc   1140

ttcgccaaca gcctggtgta cggcgcctct gacagcaacg tctatgacct cctaaaggac   1200

ctagaggaag gcatccaaac gctgatgggg aggctggaag atggcagccc ccggactggg   1260

cagatcttca agcagaccta cagcaagttc gacacaaact cacacaacga tgacgcacta   1320

ctcaagaact acgggctgct ctactgcttc aggaaggaca tggacaaggt cgagacattc   1380

ctgcgcatcg tgcagtgccg ctctgtggag ggcagctgtg gcttctaagc ttgacctgtg   1440

aagtgaaaaa tggcgcacat tgtgcgacat tttttttgtc tgccgtttac cgctactgcg   1500

tcacggatct ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc   1560

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt   1620

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag   1680

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt   1740

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt   1800

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt   1860

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt   1920

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttca ggtggcactt   1980

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt   2040

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta   2100

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg   2160

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac   2220

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg   2280

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc   2340

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg   2400

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat   2460

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg   2520

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg   2580

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc   2640

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt   2700

cccggcaaca attgatagac tggatggagg cggataaagt tgcaggacca cttctgcgct   2760

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtggctctc   2820

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca   2880

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct   2940

cactgattaa gcattggtag gaattaatga tgtctcgttt agataaaagt aaagtgatta   3000

acagcgcatt agagctgctt aatgaggtcg gaatcgaagg tttaacaacc cgtaaactcg   3060

cccagaagct aggtgtagag cagcctacat tgtattggca tgtaaaaaat aagcgggctt   3120

tgctcgacgc cttagccatt gagatgttag ataggcacca tactcacttt tgccctttag   3180

aaggggaaag ctggcaagat tttttacgta ataacgctaa aagttttaga tgtgctttac   3240

taagtcatcg cgatggagca aaagtacatt taggtacacg gcctacagaa aaacagtatg   3300

aaactctcga aaatcaatta gcctttttat gccaacaagg tttttcacta gagaatgcat   3360

tatatgcact cagcgcagtg gggcatttta ctttaggttg cgtattggaa gatcaagagc   3420

atcaagtcgc taaagaagaa agggaaacac ctactactga tagtatgccg ccattattac   3480

gacaagctat cgaattattt gatcaccaag gtgcagagcc agccttctta ttcggccttg   3540

aattgatcat atgcggatta gaaaaacaac ttaaatgtga aagtgggtct taaaagcagc   3600

ataacctttt tccgtgatgg taacttcact agtttaaaag gatctaggtg aagatccttt   3660

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc   3720

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct   3780

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa   3840

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag   3900

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc   3960

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg   4020

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca   4080

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat   4140

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg   4200

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc   4260

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc   4320

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc   4380

cttttgctca cat                                                      4393


<210>  47
<211>  404
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       His6-PA#1(200)-hGH as encoded on pCHO-PA#1(200)-hGH"

<400>  47

Ser His His His His His His Gly Ala Ser Ser Ser Ala Ala Pro Ala 
1               5                   10                  15      


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
    50                  55                  60                  


Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro 
65                  70                  75                  80  


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
                85                  90                  95      


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
            100                 105                 110         


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
        115                 120                 125             


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
    130                 135                 140                 


Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro 
145                 150                 155                 160 


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
                165                 170                 175     


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
            180                 185                 190         


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
        195                 200                 205             


Ala Ala Pro Ala Ala Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp 
    210                 215                 220                 


Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr 
225                 230                 235                 240 


Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser 
                245                 250                 255     


Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro 
            260                 265                 270         


Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu 
        275                 280                 285             


Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln 
    290                 295                 300                 


Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp 
305                 310                 315                 320 


Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr 
                325                 330                 335     


Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe 
            340                 345                 350         


Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala 
        355                 360                 365             


Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp 
    370                 375                 380                 


Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly 
385                 390                 395                 400 


Ser Cys Gly Phe 
                


<210>  48
<211>  6653
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pCHO-PA#1(200)-hGH"

<400>  48
ctattctata gtgtcaccta aatgctagag ctcgctgatc agcctcgact gtgccttcta     60

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca    120

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc    180

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata    240

gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg    300

gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg    360

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct    420

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cggggcatcc    480

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg    540

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt    600

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg    660

tctattcttt tgatttataa gggattttgg ggatttcggc ctattggtta aaaaatgagc    720

tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg    780

aaagtcccca ggctccccag gcaggcagaa gtatgcaaag catgcatctc aattagtcag    840

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc    900

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc    960

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg   1020

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag   1080

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag   1140

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt   1200

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg   1260

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg   1320

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg   1380

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg   1440

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca   1500

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc   1560

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc   1620

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca   1680

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga   1740

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg   1800

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg   1860

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg   1920

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga   1980

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag   2040

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct   2100

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata   2160

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg   2220

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag   2280

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc   2340

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta   2400

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca   2460

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc   2520

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc   2580

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat   2640

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt   2700

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg   2760

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc   2820

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt   2880

ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa   2940

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta   3000

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa   3060

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa   3120

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt   3180

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt   3240

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat   3300

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat   3360

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc   3420

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc   3480

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta   3540

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga   3600

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg   3660

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc   3720

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat   3780

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag   3840

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat   3900

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa   3960

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa   4020

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga   4080

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg   4140

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc   4200

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg   4260

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact   4320

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat   4380

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt   4440

gccacctgac gtcgacggat cgggagatct cccgatcccc tatggtcgac tctcagtaca   4500

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc   4560

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc   4620

atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat   4680

acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt   4740

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga   4800

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca   4860

atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca   4920

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg   4980

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc   5040

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt   5100

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt   5160

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg   5220

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctctggcta   5280

actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta tagggagacc   5340

caagctgcca ccatggctac aggctcccgg acgtccctgc tcctggcttt tggcctgctc   5400

tgcctgccct ggcttcaaga gggcagcgct agccatcacc accatcacca tggcgccagc   5460

tcttctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5520

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5580

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5640

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5700

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5760

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5820

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5880

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   5940

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   6000

cctgctgccg ctccagctgc acctgctcca gcagcacctg ctgcaccagc tccggctgct   6060

cctgctgcct tcccaaccat tcccttatcc aggctttttg acaacgctat gctccgcgcc   6120

catcgtctgc accagctggc ctttgacacc taccaggagt ttgaagaagc ctatatccca   6180

aaggaacaga agtattcatt cctgcagaac ccccagacct ccctctgttt ctcagagtct   6240

attccgacac cctccaacag ggaggaaaca caacagaaat ccaacctaga gctgctccgc   6300

atctccctgc tgctcatcca gtcgtggctg gagcccgtgc agttcctcag gagtgtcttc   6360

gccaacagcc tggtgtacgg cgcctctgac agcaacgtct atgacctcct aaaggaccta   6420

gaggaaggca tccaaacgct gatggggagg ctggaagatg gcagcccccg gactgggcag   6480

atcttcaagc agacctacag caagttcgac acaaactcac acaacgatga cgcactactc   6540

aagaactacg ggctgctcta ctgcttcagg aaggacatgg acaaggtcga gacattcctg   6600

cgcatcgtgc agtgccgctc tgtggagggc agctgtggct tctaagcttg gcc          6653


<210>  49
<211>  6041
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pCHO-hGH"

<400>  49
ctattctata gtgtcaccta aatgctagag ctcgctgatc agcctcgact gtgccttcta     60

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca    120

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc    180

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata    240

gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg    300

gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg    360

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct    420

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cggggcatcc    480

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg    540

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt    600

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg    660

tctattcttt tgatttataa gggattttgg ggatttcggc ctattggtta aaaaatgagc    720

tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg    780

aaagtcccca ggctccccag gcaggcagaa gtatgcaaag catgcatctc aattagtcag    840

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc    900

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc    960

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg   1020

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag   1080

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag   1140

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt   1200

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg   1260

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg   1320

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg   1380

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg   1440

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca   1500

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc   1560

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc   1620

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca   1680

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga   1740

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg   1800

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg   1860

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg   1920

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga   1980

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag   2040

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct   2100

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata   2160

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg   2220

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag   2280

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc   2340

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta   2400

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca   2460

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc   2520

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc   2580

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat   2640

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt   2700

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg   2760

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc   2820

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt   2880

ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa   2940

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta   3000

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa   3060

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa   3120

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt   3180

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt   3240

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat   3300

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat   3360

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc   3420

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc   3480

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta   3540

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga   3600

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg   3660

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc   3720

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat   3780

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag   3840

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat   3900

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa   3960

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa   4020

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga   4080

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg   4140

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc   4200

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg   4260

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact   4320

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat   4380

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt   4440

gccacctgac gtcgacggat cgggagatct cccgatcccc tatggtcgac tctcagtaca   4500

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc   4560

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc   4620

atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat   4680

acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt   4740

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga   4800

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca   4860

atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca   4920

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg   4980

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc   5040

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt   5100

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt   5160

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg   5220

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctctggcta   5280

actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta tagggagacc   5340

caagctgcca ccatggctac aggctcccgg acgtccctgc tcctggcttt tggcctgctc   5400

tgcctgccct ggcttcaaga gggcagcgct agccatcacc accatcacca tggcgccttc   5460

ccaaccattc ccttatccag gctttttgac aacgctatgc tccgcgccca tcgtctgcac   5520

cagctggcct ttgacaccta ccaggagttt gaagaagcct atatcccaaa ggaacagaag   5580

tattcattcc tgcagaaccc ccagacctcc ctctgtttct cagagtctat tccgacaccc   5640

tccaacaggg aggaaacaca acagaaatcc aacctagagc tgctccgcat ctccctgctg   5700

ctcatccagt cgtggctgga gcccgtgcag ttcctcagga gtgtcttcgc caacagcctg   5760

gtgtacggcg cctctgacag caacgtctat gacctcctaa aggacctaga ggaaggcatc   5820

caaacgctga tggggaggct ggaagatggc agcccccgga ctgggcagat cttcaagcag   5880

acctacagca agttcgacac aaactcacac aacgatgacg cactactcaa gaactacggg   5940

ctgctctact gcttcaggaa ggacatggac aaggtcgaga cattcctgcg catcgtgcag   6000

tgccgctctg tggagggcag ctgtggcttc taagcttggc c                       6041


<210>  50
<211>  5449
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pCHO"

<400>  50
ctattctata gtgtcaccta aatgctagag ctcgctgatc agcctcgact gtgccttcta     60

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca    120

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc    180

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata    240

gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg    300

gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg    360

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct    420

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cggggcatcc    480

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg    540

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt    600

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg    660

tctattcttt tgatttataa gggattttgg ggatttcggc ctattggtta aaaaatgagc    720

tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg    780

aaagtcccca ggctccccag gcaggcagaa gtatgcaaag catgcatctc aattagtcag    840

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc    900

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc    960

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg   1020

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag   1080

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag   1140

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt   1200

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg   1260

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg   1320

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg   1380

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg   1440

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca   1500

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc   1560

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc   1620

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca   1680

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga   1740

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg   1800

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg   1860

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg   1920

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga   1980

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag   2040

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct   2100

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata   2160

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg   2220

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag   2280

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc   2340

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta   2400

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca   2460

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc   2520

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc   2580

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat   2640

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt   2700

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg   2760

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc   2820

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt   2880

ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa   2940

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta   3000

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa   3060

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa   3120

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt   3180

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt   3240

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat   3300

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat   3360

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc   3420

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc   3480

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta   3540

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga   3600

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg   3660

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc   3720

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat   3780

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag   3840

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat   3900

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa   3960

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa   4020

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga   4080

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg   4140

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc   4200

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg   4260

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact   4320

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat   4380

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt   4440

gccacctgac gtcgacggat cgggagatct cccgatcccc tatggtcgac tctcagtaca   4500

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc   4560

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc   4620

atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat   4680

acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt   4740

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga   4800

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca   4860

atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca   4920

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg   4980

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc   5040

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt   5100

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt   5160

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg   5220

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctctggcta   5280

actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta tagggagacc   5340

caagctgcca ccatggctac aggctcccgg acgtccctgc tcctggcttt tggcctgctc   5400

tgcctgccct ggcttcaaga gggcagcgct agctctagaa agcttggcc               5449


<210>  51
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       P1A1"

<400>  51

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  52
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of upper/coding strand oligodesoxynucleotide used for the 
       generation of the building block for P1A1"

<400>  52
gcccctgctc ctgctccagc acctgcacca gcacctgctc cagcaccagc tcctgcacca     60


<210>  53
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of lower/non-coding strand oligodesoxynucleotide used for the 
       generation of the building block for P1A1"

<400>  53
ggctggtgca ggagctggtg ctggagcagg tgctggtgca ggtgctggag caggagcagg     60


<210>  54
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of upper/coding strand oligodesoxynucleotide used for the 
       generation of the building block for P1A3"

<400>  54
gccgctgcac ctgctgcagc acctgctgca gctccagcag ctgctcctgc agcagctcca     60


<210>  55
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of lower/non-coding strand oligodesoxynucleotide used for the 
       generation of the building block for P1A3"

<400>  55
ggctggagct gctgcaggag cagctgctgg agctgcagca ggtgctgcag caggtgcagc     60


<210>  56
<211>  417
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       the Fab light chain fused with the P1A1(200) polymer as encoded 
       on pFab-P1A1(200)"

<400>  56

Asp Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Ser Ala Pro Ala Pro Ala Pro Ala Pro 
    210                 215                 220                 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
225                 230                 235                 240 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
                245                 250                 255     


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            260                 265                 270         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        275                 280                 285             


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
    290                 295                 300                 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
305                 310                 315                 320 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
                325                 330                 335     


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            340                 345                 350         


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        355                 360                 365             


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
    370                 375                 380                 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
385                 390                 395                 400 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
                405                 410                 415     


Ala 
    


<210>  57
<211>  417
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: amino acid sequence of
       the Fab light chain fused with the P1A3(200) polymer as encoded 
       on pFab-P1A3(200)"

<400>  57

Asp Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Ser Ala Ala Ala Pro Ala Ala Ala Pro 
    210                 215                 220                 


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
225                 230                 235                 240 


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
                245                 250                 255     


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
            260                 265                 270         


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
        275                 280                 285             


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
    290                 295                 300                 


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
305                 310                 315                 320 


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
                325                 330                 335     


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
            340                 345                 350         


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
        355                 360                 365             


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
    370                 375                 380                 


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
385                 390                 395                 400 


Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Pro 
                405                 410                 415     


Ala 
    


<210>  58
<211>  5210
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pFab-P1A1(200)"

<400>  58
acccgacacc atcgaatggc cagatgatta attcctaatt tttgttgaca ctctatcatt     60

gatagagtta ttttaccact ccctatcagt gatagagaaa agtgaaatga atagttcgac    120

aaaaatctag ataacgaggg caaaaaatga aaaagacagc tatcgcgatt gcagtggcac    180

tggctggttt cgctaccgta gcgcaggccg aagttaaact gcaggaatcc ggtggtggtc    240

tggttcagcc aggtggttcc ctgcggctct cgtgtgctgc ttccggtttc aacatcaaag    300

acacctacat ccactgggtt cgtcaggctc cgggtaaagg cctggaatgg gttgctcgta    360

tctacccgac caacggttac accaggtatg ccgattcagt taaaggtcgt ttcaccatct    420

cggccgacac ttccaaaaac accgcttacc tccagatgaa ctccctgcgt gctgaagaca    480

cagctgttta ttattgctcc cgttggggtg gtgacggttt ctacgctatg gactactggg    540

gtcagggtac cctggtcacc gtctcctcag cctccaccaa gggcccatcg gtcttccccc    600

tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc ctggtcaagg    660

actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc    720

acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgactg    780

tgccctccag cagcttgggc acccagacct acatctgcaa cgttaatcac aaacccagca    840

acaccaaggt cgacaagaaa gttgagccca aatcttgcca tcaccaccat caccattaat    900

aaccatggag aaaataaagt gaaacaaagc actattgcac tggcactctt accgttactg    960

tttacccctg tgacaaaagc cgacatcgag ctcacccaat ccccgtcctc cctgtccgct   1020

tccgttggcg accgtgttac catcacgtgt agggcctcgc aagacgtaaa caccgccgta   1080

gcgtggtatc agcagaaacc cgggaaagct ccgaaactgc tgatctatag cgcttccttc   1140

ctgtattccg gagttccgag caggttcagt ggttcccgtt ccggtaccga cttcaccctg   1200

acgatatcct ccctccagcc ggaagacttc gctacctact actgtcaaca gcactacacc   1260

accccgccga ccttcggtca gggtaccaaa ctcgagatca aacggactgt ggctgcacca   1320

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg   1380

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc   1440

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac   1500

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc   1560

tgcgaagtca cccatcaggg cctgagttcg cccgtcacaa agagcttcaa ccgcggagag   1620

tgctcttctg cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   1680

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   1740

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   1800

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   1860

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   1920

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   1980

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   2040

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   2100

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   2160

cctgcaccag cccctgctcc tgctccagca cctgcaccag cacctgctcc agcaccagct   2220

cctgcaccag cctgaagagc ttaagcttga cctgtgaagt gaaaaatggc gcacattgtg   2280

cgacattttt tttgtctgcc gtttaccgct actgcgtcac ggatctccac gcgccctgta   2340

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca   2400

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct   2460

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc   2520

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat   2580

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc   2640

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc   2700

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta   2760

acaaaatatt aacgtttaca atttcaggtg gcacttttcg gggaaatgtg cgcggaaccc   2820

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct   2880

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg   2940

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg   3000

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc   3060

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca   3120

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac   3180

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa   3240

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg   3300

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt   3360

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg   3420

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc   3480

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaattg atagactgga   3540

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta   3600

ttgctgataa atctggagcc ggtgagcgtg gctctcgcgg tatcattgca gcactggggc   3660

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg   3720

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaggaat   3780

taatgatgtc tcgtttagat aaaagtaaag tgattaacag cgcattagag ctgcttaatg   3840

aggtcggaat cgaaggttta acaacccgta aactcgccca gaagctaggt gtagagcagc   3900

ctacattgta ttggcatgta aaaaataagc gggctttgct cgacgcctta gccattgaga   3960

tgttagatag gcaccatact cacttttgcc ctttagaagg ggaaagctgg caagattttt   4020

tacgtaataa cgctaaaagt tttagatgtg ctttactaag tcatcgcgat ggagcaaaag   4080

tacatttagg tacacggcct acagaaaaac agtatgaaac tctcgaaaat caattagcct   4140

ttttatgcca acaaggtttt tcactagaga atgcattata tgcactcagc gcagtggggc   4200

attttacttt aggttgcgta ttggaagatc aagagcatca agtcgctaaa gaagaaaggg   4260

aaacacctac tactgatagt atgccgccat tattacgaca agctatcgaa ttatttgatc   4320

accaaggtgc agagccagcc ttcttattcg gccttgaatt gatcatatgc ggattagaaa   4380

aacaacttaa atgtgaaagt gggtcttaaa agcagcataa cctttttccg tgatggtaac   4440

ttcactagtt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc   4500

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt   4560

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac   4620

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct   4680

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact   4740

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg   4800

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata   4860

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga   4920

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag   4980

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg   5040

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac   5100

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca   5160

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg              5210


<210>  59
<211>  5210
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pFab-P1A3(200)"

<400>  59
acccgacacc atcgaatggc cagatgatta attcctaatt tttgttgaca ctctatcatt     60

gatagagtta ttttaccact ccctatcagt gatagagaaa agtgaaatga atagttcgac    120

aaaaatctag ataacgaggg caaaaaatga aaaagacagc tatcgcgatt gcagtggcac    180

tggctggttt cgctaccgta gcgcaggccg aagttaaact gcaggaatcc ggtggtggtc    240

tggttcagcc aggtggttcc ctgcggctct cgtgtgctgc ttccggtttc aacatcaaag    300

acacctacat ccactgggtt cgtcaggctc cgggtaaagg cctggaatgg gttgctcgta    360

tctacccgac caacggttac accaggtatg ccgattcagt taaaggtcgt ttcaccatct    420

cggccgacac ttccaaaaac accgcttacc tccagatgaa ctccctgcgt gctgaagaca    480

cagctgttta ttattgctcc cgttggggtg gtgacggttt ctacgctatg gactactggg    540

gtcagggtac cctggtcacc gtctcctcag cctccaccaa gggcccatcg gtcttccccc    600

tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc ctggtcaagg    660

actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc    720

acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgactg    780

tgccctccag cagcttgggc acccagacct acatctgcaa cgttaatcac aaacccagca    840

acaccaaggt cgacaagaaa gttgagccca aatcttgcca tcaccaccat caccattaat    900

aaccatggag aaaataaagt gaaacaaagc actattgcac tggcactctt accgttactg    960

tttacccctg tgacaaaagc cgacatcgag ctcacccaat ccccgtcctc cctgtccgct   1020

tccgttggcg accgtgttac catcacgtgt agggcctcgc aagacgtaaa caccgccgta   1080

gcgtggtatc agcagaaacc cgggaaagct ccgaaactgc tgatctatag cgcttccttc   1140

ctgtattccg gagttccgag caggttcagt ggttcccgtt ccggtaccga cttcaccctg   1200

acgatatcct ccctccagcc ggaagacttc gctacctact actgtcaaca gcactacacc   1260

accccgccga ccttcggtca gggtaccaaa ctcgagatca aacggactgt ggctgcacca   1320

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg   1380

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc   1440

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac   1500

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc   1560

tgcgaagtca cccatcaggg cctgagttcg cccgtcacaa agagcttcaa ccgcggagag   1620

tgctcttctg ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   1680

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   1740

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   1800

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   1860

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   1920

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   1980

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   2040

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   2100

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   2160

gcagctccag ccgctgcacc tgctgcagca cctgctgcag ctccagcagc tgctcctgca   2220

gcagctccag cctgaagagc ttaagcttga cctgtgaagt gaaaaatggc gcacattgtg   2280

cgacattttt tttgtctgcc gtttaccgct actgcgtcac ggatctccac gcgccctgta   2340

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca   2400

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct   2460

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc   2520

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat   2580

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc   2640

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc   2700

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta   2760

acaaaatatt aacgtttaca atttcaggtg gcacttttcg gggaaatgtg cgcggaaccc   2820

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct   2880

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg   2940

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg   3000

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc   3060

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca   3120

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac   3180

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa   3240

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg   3300

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt   3360

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg   3420

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc   3480

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaattg atagactgga   3540

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta   3600

ttgctgataa atctggagcc ggtgagcgtg gctctcgcgg tatcattgca gcactggggc   3660

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg   3720

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaggaat   3780

taatgatgtc tcgtttagat aaaagtaaag tgattaacag cgcattagag ctgcttaatg   3840

aggtcggaat cgaaggttta acaacccgta aactcgccca gaagctaggt gtagagcagc   3900

ctacattgta ttggcatgta aaaaataagc gggctttgct cgacgcctta gccattgaga   3960

tgttagatag gcaccatact cacttttgcc ctttagaagg ggaaagctgg caagattttt   4020

tacgtaataa cgctaaaagt tttagatgtg ctttactaag tcatcgcgat ggagcaaaag   4080

tacatttagg tacacggcct acagaaaaac agtatgaaac tctcgaaaat caattagcct   4140

ttttatgcca acaaggtttt tcactagaga atgcattata tgcactcagc gcagtggggc   4200

attttacttt aggttgcgta ttggaagatc aagagcatca agtcgctaaa gaagaaaggg   4260

aaacacctac tactgatagt atgccgccat tattacgaca agctatcgaa ttatttgatc   4320

accaaggtgc agagccagcc ttcttattcg gccttgaatt gatcatatgc ggattagaaa   4380

aacaacttaa atgtgaaagt gggtcttaaa agcagcataa cctttttccg tgatggtaac   4440

ttcactagtt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc   4500

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt   4560

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac   4620

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct   4680

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact   4740

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg   4800

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata   4860

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga   4920

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag   4980

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg   5040

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac   5100

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca   5160

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg              5210


<210>  60
<211>  3680
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: nucleic acid sequence 
       of pSUMO-PA#1(200)"

<400>  60
gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     60

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga    120

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc    180

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg    240

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc    300

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat    360

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg    420

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag    480

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa    540

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc    600

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca    660

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc    720

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc    780

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg    840

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta    900

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag    960

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga   1020

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc   1080

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa   1140

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa   1200

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc   1260

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt   1320

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc   1380

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac   1440

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca   1500

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg   1560

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag   1620

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt   1680

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat   1740

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc   1800

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt   1860

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag   1920

cggagaagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca   1980

ggatctcgat cccgcgaaat taatacgact cactataggg agaccacaac ggtttccctc   2040

tagaaataat tttgtttaac tttaagaagg agatatacat atgaaacatc accaccatca   2100

ccattcggac tcagaagtca atcaagaagc taagccagag gtcaagccag aagtcaagcc   2160

tgagactcac atcaatttaa aggtgtccga tggatcttca gaaatcttct ttaagatcaa   2220

aaagaccact cctttaagaa ggctgatgga agcgttcgct aaaagacagg gtaaggaaat   2280

ggactcctta agattcttgt acgacggtat tagaattcaa gctgatcaga cccctgaaga   2340

tttggacatg gaggataacg atattattga ggctcacaga gaacagattg gtggcgccgc   2400

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2460

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2520

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2580

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2640

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2700

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2760

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2820

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2880

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgccgc   2940

tccagctgca cctgctccag cagcacctgc tgcaccagct ccggctgctc ctgctgcctg   3000

aagagcaagc ttgatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc   3060

accgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt gaggggtttt   3120

ttgctgaaag gaggaactat atccggatct ggcgtaatag cgaagaggcc cgcaccgatc   3180

gcccttccca acagttgcgc agcctgaatg gcgaatggga cgcgccctgt agcggcgcat   3240

taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag   3300

cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc   3360

aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc   3420

ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt   3480

ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa   3540

caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg   3600

cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat   3660

taacgcttac aatttaggtg                                               3680


<210>  61
<211>  201
<212>  PRT
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: PA#1(200) 
       polypeptide/polymer used for the preparation of drug conjugates 
       (made by ligation of 10 20mer encoding gene cassettes, including 
       one additional C-terminal Ala residue resulting from the downstream
       ligation site)"

<400>  61

Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
            20                  25                  30          


Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
    50                  55                  60                  


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
65                  70                  75                  80  


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
                85                  90                  95      


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
            100                 105                 110         


Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro 
        115                 120                 125             


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala 
    130                 135                 140                 


Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
                165                 170                 175     


Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala 
            180                 185                 190         


Ala Pro Ala Pro Ala Ala Pro Ala Ala 
        195                 200     


