                         SEQUENCE LISTING

<110>  Ablynx nv and MERCK Patent GmbH
 
<120>  Biological materials related to HER3

<130>  MEPAT.0008 WO

<150>  US 61/346,548
<151>  2010-05-20

<160>  444   

<170>  PatentIn version 3.5

<210>  1
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  2
<211>  642
<212>  PRT
<213>  Gallus gallus

<400>  2

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Ala Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Gln His Gln Tyr Arg Thr 
        35                  40                  45              


Leu His Lys Met Tyr Asn Asn Cys Glu Ile Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Ile Asp His Thr Gln Asp Leu Ser Phe Leu Gln Thr Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Ile Leu Ile Ala Met Asn Val Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Arg Asn Leu Arg Val Ile Arg Gly Thr Gln Phe Tyr Glu 
            100                 105                 110         


Glu Lys Tyr Ala Leu Phe Val Leu Leu Asn Tyr Asn Pro Asn Ala Thr 
        115                 120                 125             


His Ala Leu Arg Gln Leu Gly Leu Asn Arg Leu Thr Glu Ile Leu Ala 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Glu Gln Leu Cys His Val Asp Thr 
145                 150                 155                 160 


Val Glu Trp Arg Asp Ile Met Arg Asp Pro Arg Leu Glu Pro Val Val 
                165                 170                 175     


Gly Asp Asn Gly Arg Ala Cys Ala Pro Cys His Glu Ser Cys Gly Gly 
            180                 185                 190         


His Cys Trp Gly Pro Gly Pro Glu Asp Cys Gln Gln Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly Arg Cys Phe Gly Arg Ala Pro Asn 
    210                 215                 220                 


Glu Cys Cys His Glu Glu Cys Ala Gly Gly Cys Thr Gly Pro Leu Gln 
225                 230                 235                 240 


Thr His Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Leu Cys Pro Gln Pro Leu Ile Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro Asp Thr Lys Tyr Gln Tyr Gly Ser Val Cys Val Arg 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Ser Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Ser Asn Lys Met Glu Val Glu Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Ala Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ala 
                325                 330                 335     


Gly Ser His Tyr Gln Thr Val Asp Ser Ser Asn Ile Asp Ser Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Glu Gly Asp Pro Trp Arg Asn Ile Ser Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Lys His Met His Asn Phe Ser Val Phe Ser Asn Leu Glu 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Asp Asn Val Thr Ser Leu Gly Leu Arg Ser Leu Arg Glu 
        435                 440                 445             


Val Ser Ala Gly Arg Val Tyr Ile Thr Glu Asn Arg Arg Leu Cys Tyr 
    450                 455                 460                 


Leu His Thr Val Gln Trp Ala Ala Leu Ser Arg Arg Arg Ala Asp Leu 
465                 470                 475                 480 


Asp Ile Arg Asn Asn Lys Pro Arg Gly Lys Cys Gln Gln Glu Gly Lys 
                485                 490                 495     


Val Cys Asp Pro Leu Cys Ser Ala Asp Gly Cys Trp Gly Pro Gly Pro 
            500                 505                 510         


Ala Gln Cys Leu Ser Cys Arg His Tyr Ser Arg Arg Gly Val Cys Val 
        515                 520                 525             


Glu Ser Cys Ser Phe Thr Gln Gly Glu Thr Arg Glu Phe Ala Glu Gly 
    530                 535                 540                 


Thr Glu Cys Phe Glu Cys His Pro Glu Cys Glu Arg Val Glu Gly Gly 
545                 550                 555                 560 


Ile Thr Cys Asn Gly Ser Gly Ala Asp Thr Cys Thr Arg Cys Ala His 
                565                 570                 575     


Tyr Arg Asp Gly Pro His Cys Val Glu Arg Cys Pro Glu Gly Ile Leu 
            580                 585                 590         


Gly Glu Arg Gly Pro Ile Tyr Lys Tyr Pro Asp Ser Ser Arg Glu Cys 
        595                 600                 605             


Arg Pro Cys His Glu Asn Cys Thr Arg Gly Cys Thr Gly Pro Leu Leu 
    610                 615                 620                 


Gln Asp Cys Leu Gly Asp Ala Leu Pro Ser Ala Arg Arg Ala Pro Thr 
625                 630                 635                 640 


Val Ile 
        


<210>  3
<211>  649
<212>  PRT
<213>  Macaca fascicularis

<400>  3

Met Arg Ala Asn Gly Ala Leu Gln Val Leu Gly Leu Leu Phe Asn Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Lys Asp Ile Val Arg Asp Gln Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Leu Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Pro Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met Tyr Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr His His His His His His 
                645                 


<210>  4
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr His His His His His His 
                645                 


<210>  5
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  5

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly Arg Cys Phe Gly Arg Ala Pro Asn 
    210                 215                 220                 


Glu Cys Cys His Glu Glu Cys Ala Gly Gly Cys Thr Gly Pro Leu Gln 
225                 230                 235                 240 


Thr His Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Leu Cys Pro Gln Pro Leu Ile Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro Asp Thr Lys Tyr Gln Tyr Gly Ser Val Cys Val Arg 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Ser Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Ser Asn Lys Met Glu Val Glu Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Ala Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ala 
                325                 330                 335     


Gly Ser His Tyr Gln Thr Val Asp Ser Ser Asn Ile Asp Ser Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Glu Gly Asp Pro Trp Arg Asn Ile Ser Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Lys His Met His Asn Phe Ser Val Phe Ser Asn Leu Glu 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Asp Asn Val Thr Ser Leu Gly Leu Arg Ser Leu Arg Glu 
        435                 440                 445             


Val Ser Ala Gly Arg Val Tyr Ile Thr Glu Asn Arg Arg Leu Cys Tyr 
    450                 455                 460                 


Leu His Thr Val Gln Trp Ala Ala Leu Ser Arg Arg Arg Ala Asp Leu 
465                 470                 475                 480 


Asp Ile Arg Asn Asn Lys Pro Arg Gly Lys Cys Gln Gln Glu Gly Lys 
                485                 490                 495     


Val Cys Asp Pro Leu Cys Ser Ala Asp Gly Cys Trp Gly Pro Gly Pro 
            500                 505                 510         


Ala Gln Cys Leu Ser Cys Arg His Tyr Ser Arg Arg Gly Val Cys Val 
        515                 520                 525             


Glu Ser Cys Ser Phe Thr Gln Gly Glu Thr Arg Glu Phe Ala Glu Gly 
    530                 535                 540                 


Thr Glu Cys Phe Glu Cys His Pro Glu Cys Glu Arg Val Glu Gly Gly 
545                 550                 555                 560 


Ile Thr Cys Asn Gly Ser Gly Ala Asp Thr Cys Thr Arg Cys Ala His 
                565                 570                 575     


Tyr Arg Asp Gly Pro His Cys Val Glu Arg Cys Pro Glu Gly Ile Leu 
            580                 585                 590         


Gly Glu Arg Gly Pro Ile Tyr Lys Tyr Pro Asp Ser Ser Arg Glu Cys 
        595                 600                 605             


Arg Pro Cys His Glu Asn Cys Thr Arg Gly Cys Thr Gly Pro Leu Leu 
    610                 615                 620                 


Gln Asp Cys Leu Gly Asp Ala Leu Pro Ser Ala Arg Arg Ala Pro Thr 
625                 630                 635                 640 


Val Ile 
        


<210>  6
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  6

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Ala Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Gln His Gln Tyr Arg Thr 
        35                  40                  45              


Leu His Lys Met Tyr Asn Asn Cys Glu Ile Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Ile Asp His Thr Gln Asp Leu Ser Phe Leu Gln Thr Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Ile Leu Ile Ala Met Asn Val Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Arg Asn Leu Arg Val Ile Arg Gly Thr Gln Phe Tyr Glu 
            100                 105                 110         


Glu Lys Tyr Ala Leu Phe Val Leu Leu Asn Tyr Asn Pro Asn Ala Thr 
        115                 120                 125             


His Ala Leu Arg Gln Leu Gly Leu Asn Arg Leu Thr Glu Ile Leu Ala 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Glu Gln Leu Cys His Val Asp Thr 
145                 150                 155                 160 


Val Glu Trp Arg Asp Ile Met Arg Asp Pro Arg Leu Glu Pro Val Val 
                165                 170                 175     


Gly Asp Asn Gly Arg Ala Cys Ala Pro Cys His Glu Ser Cys Gly Gly 
            180                 185                 190         


His Cys Trp Gly Pro Gly Pro Glu Asp Cys Gln Gln Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ala 
                325                 330                 335     


Gly Ser His Tyr Gln Thr Val Asp Ser Ser Asn Ile Asp Ser Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Glu Gly Asp Pro Trp Arg Asn Ile Ser Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Lys His Met His Asn Phe Ser Val Phe Ser Asn Leu Glu 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Asp Asn Val Thr Ser Leu Gly Leu Arg Ser Leu Arg Glu 
        435                 440                 445             


Val Ser Ala Gly Arg Val Tyr Ile Thr Glu Asn Arg Arg Leu Cys Tyr 
    450                 455                 460                 


Leu His Thr Val Gln Trp Ala Ala Leu Ser Arg Arg Arg Ala Asp Leu 
465                 470                 475                 480 


Asp Ile Arg Asn Asn Lys Pro Arg Gly Lys Cys Gln Gln Glu Gly Lys 
                485                 490                 495     


Val Cys Asp Pro Leu Cys Ser Ala Asp Gly Cys Trp Gly Pro Gly Pro 
            500                 505                 510         


Ala Gln Cys Leu Ser Cys Arg His Tyr Ser Arg Arg Gly Val Cys Val 
        515                 520                 525             


Glu Ser Cys Ser Phe Thr Gln Gly Glu Thr Arg Glu Phe Ala Glu Gly 
    530                 535                 540                 


Thr Glu Cys Phe Glu Cys His Pro Glu Cys Glu Arg Val Glu Gly Gly 
545                 550                 555                 560 


Ile Thr Cys Asn Gly Ser Gly Ala Asp Thr Cys Thr Arg Cys Ala His 
                565                 570                 575     


Tyr Arg Asp Gly Pro His Cys Val Glu Arg Cys Pro Glu Gly Ile Leu 
            580                 585                 590         


Gly Glu Arg Gly Pro Ile Tyr Lys Tyr Pro Asp Ser Ser Arg Glu Cys 
        595                 600                 605             


Arg Pro Cys His Glu Asn Cys Thr Arg Gly Cys Thr Gly Pro Leu Leu 
    610                 615                 620                 


Gln Asp Cys Leu Gly Asp Ala Leu Pro Ser Ala Arg Arg Ala Pro Thr 
625                 630                 635                 640 


Val Ile 
        


<210>  7
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  7

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Ala Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Gln His Gln Tyr Arg Thr 
        35                  40                  45              


Leu His Lys Met Tyr Asn Asn Cys Glu Ile Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Ile Asp His Thr Gln Asp Leu Ser Phe Leu Gln Thr Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Ile Leu Ile Ala Met Asn Val Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Arg Asn Leu Arg Val Ile Arg Gly Thr Gln Phe Tyr Glu 
            100                 105                 110         


Glu Lys Tyr Ala Leu Phe Val Leu Leu Asn Tyr Asn Pro Asn Ala Thr 
        115                 120                 125             


His Ala Leu Arg Gln Leu Gly Leu Asn Arg Leu Thr Glu Ile Leu Ala 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Glu Gln Leu Cys His Val Asp Thr 
145                 150                 155                 160 


Val Glu Trp Arg Asp Ile Met Arg Asp Pro Arg Leu Glu Pro Val Val 
                165                 170                 175     


Gly Asp Asn Gly Arg Ala Cys Ala Pro Cys His Glu Ser Cys Gly Gly 
            180                 185                 190         


His Cys Trp Gly Pro Gly Pro Glu Asp Cys Gln Gln Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly Arg Cys Phe Gly Arg Ala Pro Asn 
    210                 215                 220                 


Glu Cys Cys His Glu Glu Cys Ala Gly Gly Cys Thr Gly Pro Leu Gln 
225                 230                 235                 240 


Thr His Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Leu Cys Pro Gln Pro Leu Ile Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro Asp Thr Lys Tyr Gln Tyr Gly Ser Val Cys Val Arg 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Ser Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Ser Asn Lys Met Glu Val Glu Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Ala Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ala 
                325                 330                 335     


Gly Ser His Tyr Gln Thr Val Asp Ser Ser Asn Ile Asp Ser Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Glu Gly Asp Pro Trp Arg Asn Ile Ser Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Lys His Met His Asn Phe Ser Val Phe Ser Asn Leu Glu 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Asp Asn Val Thr Ser Leu Gly Leu Arg Ser Leu Arg Glu 
        435                 440                 445             


Val Ser Ala Gly Arg Val Tyr Ile Thr Glu Asn Arg Arg Leu Cys Tyr 
    450                 455                 460                 


Leu His Thr Val Gln Trp Ala Ala Leu Ser Arg Arg Arg Ala Asp Leu 
465                 470                 475                 480 


Asp Ile Arg Asn Asn Lys Pro Arg Gly Lys Cys Gln Gln Glu Gly Lys 
                485                 490                 495     


Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro 
            500                 505                 510         


Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val 
        515                 520                 525             


Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu 
    530                 535                 540                 


Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr 
545                 550                 555                 560 


Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His 
                565                 570                 575     


Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu 
            580                 585                 590         


Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys 
        595                 600                 605             


Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu 
    610                 615                 620                 


Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu 
625                 630                 635                 640 


Thr Met 
        


<210>  8
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Lys Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  9
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Ala  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  10
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210>  11
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  12
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  14
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Gly Ser Ala 
            20                  25                  30          


Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Asp Glu Arg Ile Trp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Thr Thr Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Ser Asp Val Lys Val Arg His Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Arg Arg Arg Gly Tyr Ser Asp Leu Cys Arg Phe Tyr Tyr 
            100                 105                 110         


Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  21
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Tyr Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Arg Asp Gly Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ala Ser Asp Tyr Gly Leu Gly Leu Glu Leu Phe His Asp 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  22
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  23
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Gly Asp Gly Arg Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Ser Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ile Trp Gly Pro Tyr Cys Ser Asp Ser Tyr Glu Tyr Leu Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  24
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Ile 
        35                  40                  45              


Ser Cys Ile Ser Asn Asn Asp Gly Ser Thr Tyr Tyr Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Pro His Gly Cys Trp Tyr Asp Leu Ile Pro Leu Gln Ala 
            100                 105                 110         


Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Ser Met Phe Arg Phe Tyr 
            20                  25                  30          


His Met Ala Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Tyr Thr Gly Gly Asp Thr Ile Tyr Gly Asp Ser Val Leu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Phe Arg Glu Tyr His Ile Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  27
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  27
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgtag cctctggatt cacgttcagt tcctactgga tgtattgggt ccgtcaggct      120

ccagggaagg gggtcgagtg ggtctcagca attagtcctg gtggtgttga acgatataca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacac actgtatctc      240

caaatgaaca gtctgaaatc tgaggacacg gccatgtatt actgtgcacg actaacatct      300

tttgccacac ccgagagcca ggggacccag gtcaccgtct cctcagcggc cgcagaacaa      360

aaactcatct cagaagagga tctgaatggg gccgcacatc atcatcatca tcat            414


<210>  28
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  28
gaggtgcaat tggtggagtc tgggggaggc ttggtgcaac ctggggggtc tctgagactc       60

tcctgcgcag cctctggaag catcggcggt ctcaatgcca tggcctggta ccgccaggct      120

ccaggaaaag agcgcgagtt ggtcgcaggt atttttggcg ttggtagcac gaggtacgcg      180

gactccgtga agggccgatt caccatctct agagacatcg ccaagaacac ggtgtttctg      240

caaatgaaca gcctgaattc tgaggacacg gccgtttatt actgtcggat gtcaagtgtt      300

actcgtggta gttctgacta ctggggtcag gggacccagg tcaccgtctc ctcagcggcc      360

gcagaacaaa aactcatctc agaagaggat ctgaatgggg ccgcacatca tcatcatcat      420

cat                                                                    423


<210>  29
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  29
gaggtgcaat tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggact gacgttcggt agcgcgccta tgggctggta ccgccaggct      120

ccagggaagg agcgcgagtt ggtcgcttat attagtggtg atgagagaat atggtatgga      180

gactctgtga aggggcgatt caccatctcc agagacacta ccaagaacac gctgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtttatt attgtgtatc agatgttaaa      300

gtcaggcact ggggccaggg gacccaggtc accgtctcct cagcggccgc agaacaaaaa      360

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               411


<210>  30
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  30
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatccca tgagctgggt ccgccaggct      120

ccaggaaagg ggcccgcgtg ggtctcaact gttagtcctg gtggtataac cacaagctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ttgcaaatga acagcctgaa acctgaggac acggccgtgt attactgctt aagagatctg      300

aataataggg gccaggggac ccaggtcacc gtctcctcag cggccgcaga acaaaaactc      360

atctcagaag aggatctgaa tggggccgca catcatcatc atcatcat                   408


<210>  31
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  31
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaac gctcttcaaa atcaacgcca tgggctggta ccgccaggct      120

ccagggaagc ggcgcgagtt ggtcgcactt attactagta gcgatacaac ggattatgca      180

gagtccgtgg agggccgatt caccatctcc agagacaaca cgtggaacgc ggtgtatctg      240

caaatgaaca gtctgaaacc tgaggatacg gccgtctatt actgtcactc agatcattac      300

tcgatgggtg tgcctgaaaa gcgagtcata atgtacggcc aggggaccca ggtcaccgtc      360

tcctcagcgg ccgcagaaca aaaactcatc tcagaagagg atctgaatgg ggccgcacat      420

catcatcatc atcat                                                       435


<210>  32
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  32
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaac gctcttcaaa atcaacgcca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcactt attactagta gcgatacaac ggattatgca      180

gagtccgtgg agggccgatt caccatctcc agagacaaca cgtggaacgc ggtgtatctg      240

caaatgaaca gtctgaaacc tgaggatacg gccgtctatt actgtcactc agatcattac      300

tcgatgggtg tgcctgaaaa gcgagtcata atgtacggcc aggggaccca ggtcaccgtc      360

tcctcagcgg ccgcagaaca aaaactcatc tcagaagagg atctgaatgg ggccgcacat      420

catcatcatc atcat                                                       435


<210>  33
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  33
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgggactc       60

tcctgtgtag cctctggaag catcttcaga atcaatgcca tggcctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcggaa attactgctg gtggtagcac aaactatgca      180

gactccgtga agggccgatt caccatctcc gtagacaacg cctggaacac gctgtatctg      240

caaatgaaca gcctgaaagt tgaggacacg gccgtctatt actgtaatct agatcattat      300

acgacatggg atagacggag tgcctactgg ggccagggga cccaggtcac cgtctcctca      360

gcggccgcag aacaaaaact catctcagaa gaggatctga atggggccgc acatcatcat      420

catcatcat                                                              429


<210>  34
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  34
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttcgat gattatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcgtgaggg ggtctcatgt attagtagta gtgatggtag cacagtctat      180

gcagactccg tgaagggccg attcaccatc tccagtgaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcagaacga      300

cggaggggct atagcgattt atgtaggttt tactacggca tggactactg gggcaaaggg      360

acccaggtca ccgtctcctc agcggccgca gaacaaaaac tcatctcaga agaggatctg      420

aatggggccg cacatcatca tcatcatcat                                       450


<210>  35
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  35
gaggtgcaat tggtggagtc tgggggcgga ttgatgcagg ctggggactc tctgagactc       60

tcctgtgcag cctctggacg ggccttcagt agctatgcct taggctggtt ccgccgggct      120

ccagggaagg agcgtgagtg tgtagcagcg actgaccggc ttggtgataa cacatacttt      180

ccagattccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacactgtat      240

ctacaaatga acaaccttaa gcctgaggac acggccgttt attactgcgc agcaggggcc      300

gttcggtacg gtgttagtac gagtccgatg aactataact actggggcca ggggacccag      360

gtcaccgtct cctcagcggc cgcagaacaa aaactcatct cagaagagga tctgaatggg      420

gccgcacatc atcatcatca tcat                                             444


<210>  36
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  36
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacttttgat tattatacca taggctggtt ccgccaggcc      120

ccagggaagg agcgcgaggg ggtctcatgt attagtagta gggatggtga ctcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggcgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcatcagct      300

tctgactacg ggttggggtt ggagttgttc cacgatgagt ataactactg gggccagggg      360

acccaggtca ccgtctcctc agcggccgca gaacaaaaac tcatctcaga agaggatctg      420

aatggggccg cacatcatca tcatcatcat                                       450


<210>  37
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  37
gaggtgcaat tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg cacgtactat ctcaatgcca tgggctggtt ccgccagggt      120

ccagggaagg accgtgagtt tgtagcagct atagactgga gtgatggtaa caaagactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agccgacaca      300

ccaccctggg ggcctatgat ctacatcgaa tcgtatgact cctggggcca ggggacccag      360

gtcaccgtct cctcagcggc cgcagaacaa aaactcatct cagaagagga tctgaatggg      420

gccgcacatc atcatcatca tcat                                             444


<210>  38
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  38
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttcgat ggttatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcgtgaggg ggtctcatgt attagtggtg gtgatggccg ctcatactat      180

gcagactccg tgaagggccg attcaccgtc tccagtgaca acgccaagaa cacgctgtat      240

ctggaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtcatatgg      300

ggcccttact gtagcgactc gtatgagtat ttgtatgagt atgactactg gggccagggg      360

acccaggtca ccgtctcctc agcggccgca gaacaaaaac tcatctcaga agaggatctg      420

aatggggccg cacatcatca tcatcatcat                                       450


<210>  39
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  39
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttcgat gattatacca taggctggtt ccgccaggcc      120

ccagggaagg agcgtgagga gatctcatgt attagtaaca atgatggtag cacatactat      180

acaaactccg tgaagggccg attcaccatc tccagtgaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcgtccccc      300

catggctgct ggtacgacct aatacccctt caggctgact ttggttcctg gggccagggg      360

acccaggtca ccgtctcctc agcggccgca gaacaaaaac tcatctcaga agaggatctg      420

aatggggccg cacatcatca tcatcatcat                                       450


<210>  40
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  40
gaggtgcaat tggtggagtc tgggggaggg ttggtgcagc ctggggggtc tctgagactc       60

tcctgttcag cctctggaag catcttcggt ctcaatgcca tgggctggta ccgccagact      120

ccagggaagg agcgcgagtt ggtcgcaggt attactagta ttactagagt tggtagtaca      180

aggtatgcgg actccgcgaa gggccgattc accatctccg gagactacgc caagaacacg      240

gtgtatctgc aaatgaacag cctgaaacct gaggacacgg gcgtttatta ctgtcggatg      300

tcaatcgtta aaagtggtgg tgctgactac tggggtcagg ggacccaggt caccgtctcc      360

tcagcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgcacatcat      420

catcatcatc at                                                          432


<210>  41
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  41
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgaagctc       60

tcctgtgtag cctctggaag catgttcaga ttctatcaca tggcctggta ccgccaggct      120

ccaggggagc agcgcgagct ggtcgcacgt atctatactg gtggtgacac aatctatgga      180

gactccgtgc tgggccgatt caccatctcc agagacaatt ccaagaacac ggtgtatcta      240

caaatgaaca ccctgaaacc tgaggacacg ggcgtctatt actgtaatgc cttcagggag      300

tatcacatct ggggccaggg gacccaggtc accgtctcct cagcggccgc agaacaaaaa      360

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               411


<210>  42
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  43
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly 
            20                  25                  30  


<210>  44
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Gly 
            20                  25                  30  


<210>  45
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  46
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys 
            20                  25                  30  


<210>  47
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys 
            20                  25                  30  


<210>  48
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg 
            20                  25                  30  


<210>  49
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  50
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser 
            20                  25                  30  


<210>  51
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr 
            20                  25                  30  


<210>  53
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  54
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  55
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly 
            20                  25                  30  


<210>  56
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework1 sequence

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Ser Met Phe Arg 
            20                  25                  30  


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  57

Ser Tyr Trp Met Tyr 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  58

Leu Asn Ala Met Ala 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  59

Ser Ala Pro Met Gly 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  60

Ser Tyr Pro Met Ser 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  61

Ile Asn Ala Met Gly 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  62

Ile Asn Ala Met Gly 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  63

Ile Asn Ala Met Ala 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  64

Asp Tyr Ala Ile Gly 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  65

Ser Tyr Ala Leu Gly 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  66

Tyr Tyr Thr Ile Gly 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  67

Leu Asn Ala Met Gly 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  68

Gly Tyr Ala Ile Gly 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  69

Asp Tyr Thr Ile Gly 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  70

Leu Asn Ala Met Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  71

Phe Tyr His Met Ala 
1               5   


<210>  72
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  72

Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val Ser 
1               5                   10                  


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  73

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
1               5                   10                  


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  74

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  75

Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser 
1               5                   10                  


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  76

Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala 
1               5                   10                  


<210>  77
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  77

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  78

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  79

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  80

Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val Ala 
1               5                   10                  


<210>  81
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  81

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  82
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  82

Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ala 
1               5                   10                  


<210>  83
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  83

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  84
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  84

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Ile Ser 
1               5                   10                  


<210>  85
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  85

Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val Ala 
1               5                   10                  


<210>  86
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework2 sequence

<400>  86

Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  87
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  87

Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  88

Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  89
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  89

Tyr Ile Ser Gly Asp Glu Arg Ile Trp Tyr Gly Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  90

Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  91

Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly 
1               5                   10                  15      


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  92

Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly 
1               5                   10                  15      


<210>  93
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  93

Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  94

Cys Ile Ser Ser Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  95

Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  96

Cys Ile Ser Ser Arg Asp Gly Asp Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  97

Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  98

Cys Ile Ser Gly Gly Asp Gly Arg Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  99

Cys Ile Ser Asn Asn Asp Gly Ser Thr Tyr Tyr Thr Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  100

Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp Ser 
1               5                   10                  15      


Ala Lys Gly 
            


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  101

Arg Ile Tyr Thr Gly Gly Asp Thr Ile Tyr Gly Asp Ser Val Leu Gly 
1               5                   10                  15      


<210>  102
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  102

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  103
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  103

Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met 
            20                  25                  30          


<210>  104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  104

Arg Phe Thr Ile Ser Arg Asp Thr Thr Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val Ser 
            20                  25                  30          


<210>  105
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  105

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg 
            20                  25                  30          


<210>  106
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  106

Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser 
            20                  25                  30          


<210>  107
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  107

Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser 
            20                  25                  30          


<210>  108
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  108

Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu 
            20                  25                  30          


<210>  109
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  109

Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  110
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  110

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  111
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  111

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  112
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  112

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  113
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  113

Arg Phe Thr Val Ser Ser Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val 
            20                  25                  30          


<210>  114
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  114

Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  115
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  115

Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg Met 
            20                  25                  30          


<210>  116
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework3 sequence

<400>  116

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  117

Leu Thr Ser Phe Ala Thr Pro 
1               5           


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  118

Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr 
1               5                   10  


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  119

Asp Val Lys Val Arg His 
1               5       


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  120

Asp Leu Asn Asn 
1               


<210>  121
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  121

Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met 
1               5                   10                  


<210>  122
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  122

Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met 
1               5                   10                  


<210>  123
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  123

Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr 
1               5                   10          


<210>  124
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  124

Glu Arg Arg Arg Gly Tyr Ser Asp Leu Cys Arg Phe Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  125
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  125

Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr Asn Tyr 
1               5                   10                  15      


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  126

Ser Ala Ser Asp Tyr Gly Leu Gly Leu Glu Leu Phe His Asp Glu Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  127
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  127

Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser 
1               5                   10                  15      


<210>  128
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  128

Ile Trp Gly Pro Tyr Cys Ser Asp Ser Tyr Glu Tyr Leu Tyr Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  129
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  129

Ser Pro His Gly Cys Trp Tyr Asp Leu Ile Pro Leu Gln Ala Asp Phe 
1               5                   10                  15      


Gly Ser 
        


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  130

Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr 
1               5                   10  


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  131

Phe Arg Glu Tyr His Ile 
1               5       


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  132

Glu Ser Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  133

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  134

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  135

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  136

Tyr Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  137

Tyr Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  138

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  139

Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  140

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  141

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  142

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  143

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  144

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  145

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework4 sequence

<400>  146

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  147
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            180                 185                 190         


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            260                 265                 270         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            340                 345                 350         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 


<210>  148
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            180                 185                 190         


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        195                 200                 205             


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  149
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            180                 185                 190         


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            260                 265                 270         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            340                 345                 350         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 


<210>  150
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            180                 185                 190         


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        195                 200                 205             


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  151
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Met Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Arg Ala Phe Ser Ser Tyr Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly 
            180                 185                 190         


Lys Glu Arg Glu Phe Val Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr 
        195                 200                 205             


Tyr Phe Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Ala Gly Ala Val Arg Tyr Gly Val Ser 
                245                 250                 255     


Thr Ser Pro Met Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  152
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
                165                 170                 175     


Phe Thr Phe Ser Ser Tyr Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Val Glu Trp Val Ser Ala Ile Ser Pro Gly Gly Val Glu Arg 
        195                 200                 205             


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Met Tyr Tyr Cys Ala Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        275                 280                 285             


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    290                 295                 300                 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser 
385                 


<210>  153
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln Gly Pro Gly 
            180                 185                 190         


Lys Asp Arg Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys 
        195                 200                 205             


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp Gly Pro Met 
                245                 250                 255     


Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  154
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Val Ala Ser Gly 
                165                 170                 175     


Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Val Asp Asn Ala 
    210                 215                 220                 


Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp Asp Arg Arg 
                245                 250                 255     


Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
                325                 330                 335     


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
    370                 375                 380                 


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 


<210>  155
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            180                 185                 190         


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            260                 265                 270         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            340                 345                 350         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 


<210>  156
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            180                 185                 190         


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        195                 200                 205             


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  157
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            180                 185                 190         


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            260                 265                 270         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            340                 345                 350         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 


<210>  158
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            180                 185                 190         


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        195                 200                 205             


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                245                 250                 255     


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
305                 310                 315                 320 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        355                 360                 365             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser 
                


<210>  159
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            180                 185                 190         


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        195                 200                 205             


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  160
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Tyr Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val Ser Ala Ile Ser Pro 
        195                 200                 205             


Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Leu Thr Ser Phe 
                245                 250                 255     


Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
                325                 330                 335     


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
    370                 375                 380                 


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 


<210>  161
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile Asp Trp 
        195                 200                 205             


Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro 
                245                 250                 255     


Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
305                 310                 315                 320 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        355                 360                 365             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser 
                


<210>  162
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Gly Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala 
        195                 200                 205             


Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr 
                245                 250                 255     


Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  163
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val Ser Pro 
        195                 200                 205             


Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Asn 
                245                 250                 255     


Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser 
385                 390         


<210>  164
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met 
145                 150                 155                 160 


Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala 
                165                 170                 175     


Phe Ser Ser Tyr Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Phe Val Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe 
        195                 200                 205             


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser 
                245                 250                 255     


Pro Met Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  165
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                165                 170                 175     


Tyr Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp 
            180                 185                 190         


Arg Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr 
                245                 250                 255     


Ile Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  166
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile 
                165                 170                 175     


Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
            180                 185                 190         


Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser 
385                 390         


<210>  167
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Pro Ala Trp Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
    290                 295                 300                 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
305                 310                 315                 320 


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
        355                 360                 365             


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser 
385 


<210>  168
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp 
        195                 200                 205             


Tyr Ala Glu Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr 
    210                 215                 220                 


Trp Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Met Gly Val Pro Glu 
                245                 250                 255     


Lys Arg Val Ile Met Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        275                 280                 285             


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
    290                 295                 300                 


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                325                 330                 335     


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        355                 360                 365             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
    370                 375                 380                 


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395     


<210>  169
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            180                 185                 190         


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        195                 200                 205             


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                245                 250                 255     


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser 
                405     


<210>  170
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu 
                165                 170                 175     


Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg 
            180                 185                 190         


Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala 
        195                 200                 205             


Glu Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn 
    210                 215                 220                 


Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys His Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg 
                245                 250                 255     


Val Ile Met Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
                325                 330                 335     


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
    370                 375                 380                 


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 


<210>  171
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Tyr 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val Ser Ala Ile 
        195                 200                 205             


Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Leu Thr 
                245                 250                 255     


Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        275                 280                 285             


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
    290                 295                 300                 


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                325                 330                 335     


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        355                 360                 365             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
    370                 375                 380                 


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395     


<210>  172
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly 
            180                 185                 190         


Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile 
        195                 200                 205             


Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His 
                245                 250                 255     


Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
    290                 295                 300                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                325                 330                 335     


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
        355                 360                 365             


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser 
            


<210>  173
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly 
            180                 185                 190         


Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile 
        195                 200                 205             


Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
                245                 250                 255     


Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser 
                405     


<210>  174
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val 
        195                 200                 205             


Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp 
                245                 250                 255     


Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
                325                 330                 335     


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
    370                 375                 380                 


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 


<210>  175
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Pro Ala Trp Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr 
        195                 200                 205             


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
    290                 295                 300                 


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser 
385         


<210>  176
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Ser Ile Gly Gly Leu Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Glu Arg Glu Leu Val Ala Gly Ile Phe Gly Val Gly Ser Thr Arg 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala 
    210                 215                 220                 


Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu Asn Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Arg Met Ser Ser Val Thr Arg Gly Ser Ser Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser 
385                 390         


<210>  177
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly 
                165                 170                 175     


Ser Ile Phe Gly Leu Asn Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly 
            180                 185                 190         


Lys Glu Arg Glu Leu Val Ala Gly Ile Thr Ser Ile Thr Arg Val Gly 
        195                 200                 205             


Ser Thr Arg Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly 
    210                 215                 220                 


Asp Tyr Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Gly Val Tyr Tyr Cys Arg Met Ser Ile Val Lys Ser Gly 
                245                 250                 255     


Gly Ala Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395 


<210>  178
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            180                 185                 190         


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        195                 200                 205             


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                245                 250                 255     


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            260                 265                 270         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser 
                405     


<210>  179
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            180                 185                 190         


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        195                 200                 205             


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                245                 250                 255     


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
305                 310                 315                 320 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        355                 360                 365             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser 
                


<210>  180
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            180                 185                 190         


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        195                 200                 205             


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                245                 250                 255     


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  181
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ala Thr Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            180                 185                 190         


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        195                 200                 205             


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    210                 215                 220                 


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
225                 230                 235                 240 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                245                 250                 255     


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    290                 295                 300                 


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
305                 310                 315                 320 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
            340                 345                 350         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
        355                 360                 365             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
385                 390                 395                 400 


Val Thr Val Ser Ser 
                405 


<210>  182
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Tyr Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Val Glu Trp Val Ser Ala Ile Ser Pro Gly Gly Val Glu Arg Tyr Thr 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Leu Thr Ser Phe Ala Thr Pro Glu Ser Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
    290                 295                 300                 


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser 
385         


<210>  183
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                165                 170                 175     


Gly Gly Leu Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Leu Val Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn 
    210                 215                 220                 


Thr Val Phe Leu Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Arg Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser 
385                 390 


<210>  184
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile 
                165                 170                 175     


Phe Gly Leu Asn Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Leu Val Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr 
        195                 200                 205             


Arg Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Gly Val Tyr Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
                325                 330                 335     


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390             


<210>  185
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr Ala Leu Gly 
            180                 185                 190         


Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val Ala Ala Thr 
        195                 200                 205             


Asp Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                245                 250                 255     


Ala Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr Asn Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser 
                405     


<210>  186
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  186

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Gly 
                165                 170                 175     


Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala 
            180                 185                 190         


Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile 
        195                 200                 205             


Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His 
                245                 250                 255     


Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
305                 310                 315                 320 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                325                 330                 335     


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
        355                 360                 365             


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
    370                 375                 380                 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser 
    


<210>  187
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala 
            180                 185                 190         


Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile 
        195                 200                 205             


Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser 
                245                 250                 255     


Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  188
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn Ala Met Gly 
            180                 185                 190         


Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile 
        195                 200                 205             


Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp Ser Ala Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg 
                245                 250                 255     


Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  189
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            180                 185                 190         


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        195                 200                 205             


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                245                 250                 255     


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  190
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  190

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            180                 185                 190         


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        195                 200                 205             


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    210                 215                 220                 


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
225                 230                 235                 240 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                245                 250                 255     


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    290                 295                 300                 


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
305                 310                 315                 320 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
            340                 345                 350         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
        355                 360                 365             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
385                 390                 395                 400 


Val Thr Val Ser Ser 
                405 


<210>  191
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr Ala Leu Gly Trp Phe 
            180                 185                 190         


Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val Ala Ala Thr Asp Arg 
        195                 200                 205             


Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Ala Val 
                245                 250                 255     


Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr Asn Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
305                 310                 315                 320 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        355                 360                 365             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser 
                


<210>  192
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser 
        195                 200                 205             


Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser 
                245                 250                 255     


Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
305                 310                 315                 320 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                325                 330                 335     


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
        355                 360                 365             


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
    370                 375                 380                 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser 
    


<210>  193
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Phe Gly 
        195                 200                 205             


Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser Val Thr 
                245                 250                 255     


Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  194
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn Ala Met Gly Trp Tyr 
            180                 185                 190         


Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Thr Ser 
        195                 200                 205             


Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp Ser Ala Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg Met Ser 
                245                 250                 255     


Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        275                 280                 285             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                325                 330                 335     


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
            340                 345                 350         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
    370                 375                 380                 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


<210>  195
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val Ser Pro Gly Gly 
        195                 200                 205             


Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Asn Asn Arg 
                245                 250                 255     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser 
385                 390 


<210>  196
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Met Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Arg Ala Phe Ser Ser Tyr Ala Leu Gly Trp Phe Arg Arg 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Cys Val Ala Ala Thr Asp Arg Leu Gly 
        195                 200                 205             


Asp Asn Thr Tyr Phe Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Ala Val Arg Tyr 
                245                 250                 255     


Gly Val Ser Thr Ser Pro Met Asn Tyr Asn Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  197
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  197

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Tyr Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Val Glu Trp Val Ser Ala Ile Ser Pro Gly Gly 
        195                 200                 205             


Val Glu Arg Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Leu Thr Ser Phe Ala Thr 
                245                 250                 255     


Pro Glu Ser Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser 
385                 390         


<210>  198
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp 
        195                 200                 205             


Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Met Gly 
                245                 250                 255     


Val Pro Glu Lys Arg Val Ile Met Tyr Gly Gln Gly Thr Gln Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  199
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln 
            180                 185                 190         


Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile Asp Trp Ser Asp 
        195                 200                 205             


Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp 
                245                 250                 255     


Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  200
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Val 
                165                 170                 175     


Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly 
        195                 200                 205             


Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Val 
    210                 215                 220                 


Asp Asn Ala Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Val 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp 
                245                 250                 255     


Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  201
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Phe Gly Val Gly 
        195                 200                 205             


Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu Asn Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser Val Thr Arg Gly 
                245                 250                 255     


Ser Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395 


<210>  202
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser 
                165                 170                 175     


Ala Ser Gly Ser Ile Phe Gly Leu Asn Ala Met Gly Trp Tyr Arg Gln 
            180                 185                 190         


Thr Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Thr Ser Ile Thr 
        195                 200                 205             


Arg Val Gly Ser Thr Arg Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Gly Asp Tyr Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg Met Ser Ile Val 
                245                 250                 255     


Lys Ser Gly Gly Ala Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                325                 330                 335     


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
    370                 375                 380                 


Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395             


<210>  203
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val Ser 
        195                 200                 205             


Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu 
                245                 250                 255     


Asn Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
                325                 330                 335     


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390             


<210>  204
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Asp Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr Ala Leu Gly Trp 
            180                 185                 190         


Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Cys Val Ala Ala Thr Asp 
        195                 200                 205             


Arg Leu Gly Asp Asn Thr Tyr Phe Pro Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Ala 
                245                 250                 255     


Val Arg Tyr Gly Val Ser Thr Ser Pro Met Asn Tyr Asn Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    290                 295                 300                 


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
305                 310                 315                 320 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
            340                 345                 350         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
        355                 360                 365             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
385                 390                 395                 400 


Val Thr Val Ser Ser 
                405 


<210>  205
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  205

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val Ser Ala Ile Ser 
        195                 200                 205             


Pro Gly Gly Val Glu Arg Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Leu Thr Ser 
                245                 250                 255     


Phe Ala Thr Pro Glu Ser Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395 


<210>  206
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  206

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp 
            180                 185                 190         


Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr 
        195                 200                 205             


Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr 
                245                 250                 255     


Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  207
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  207

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp 
            180                 185                 190         


Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile Asp 
        195                 200                 205             


Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr 
                245                 250                 255     


Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    290                 295                 300                 


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
305                 310                 315                 320 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
            340                 345                 350         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
        355                 360                 365             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
385                 390                 395                 400 


Val Thr Val Ser Ser 
                405 


<210>  208
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Gly Leu 
                165                 170                 175     


Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp 
            180                 185                 190         


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr 
        195                 200                 205             


Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr 
                245                 250                 255     


Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        275                 280                 285             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                325                 330                 335     


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
            340                 345                 350         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
    370                 375                 380                 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


<210>  209
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  209

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala Trp 
            180                 185                 190         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Phe 
        195                 200                 205             


Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser Val 
                245                 250                 255     


Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                325                 330                 335     


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
    370                 375                 380                 


Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395             


<210>  210
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Arg Met Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ser Ala Ser Gly Ser Ile Phe Gly Leu Asn Ala Met Gly Trp 
            180                 185                 190         


Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Thr 
        195                 200                 205             


Ser Ile Thr Arg Val Gly Ser Thr Arg Tyr Ala Asp Ser Ala Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Gly Asp Tyr Ala Lys Asn Thr Val Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg Met 
                245                 250                 255     


Ser Ile Val Lys Ser Gly Gly Ala Asp Tyr Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
305                 310                 315                 320 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                325                 330                 335     


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
        355                 360                 365             


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
    370                 375                 380                 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser 
    


<210>  211
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  211

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            180                 185                 190         


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            260                 265                 270         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            340                 345                 350         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 


<210>  212
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            180                 185                 190         


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        195                 200                 205             


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                245                 250                 255     


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
305                 310                 315                 320 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        355                 360                 365             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser 
                


<210>  213
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  213

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            180                 185                 190         


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        195                 200                 205             


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  214
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  214

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile Asp Trp 
        195                 200                 205             


Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro 
                245                 250                 255     


Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
305                 310                 315                 320 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        355                 360                 365             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser 
                


<210>  215
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  215

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val Ser Pro 
        195                 200                 205             


Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Asn 
                245                 250                 255     


Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser 
385                 390         


<210>  216
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                165                 170                 175     


Tyr Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp 
            180                 185                 190         


Arg Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr 
                245                 250                 255     


Ile Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  217
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  217

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile 
                165                 170                 175     


Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
            180                 185                 190         


Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser 
385                 390         


<210>  218
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  218

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Pro Ala Trp Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
    290                 295                 300                 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
305                 310                 315                 320 


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
        355                 360                 365             


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser 
385 


<210>  219
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  219

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            180                 185                 190         


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        195                 200                 205             


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                245                 250                 255     


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser 
                405     


<210>  220
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  220

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu 
                165                 170                 175     


Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg 
            180                 185                 190         


Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala 
        195                 200                 205             


Glu Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn 
    210                 215                 220                 


Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys His Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg 
                245                 250                 255     


Val Ile Met Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
                325                 330                 335     


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
    370                 375                 380                 


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 


<210>  221
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  221

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly 
            180                 185                 190         


Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile 
        195                 200                 205             


Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His 
                245                 250                 255     


Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
    290                 295                 300                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                325                 330                 335     


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
        355                 360                 365             


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser 
            


<210>  222
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  222

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly 
            180                 185                 190         


Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile 
        195                 200                 205             


Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
                245                 250                 255     


Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser 
                405     


<210>  223
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val 
        195                 200                 205             


Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp 
                245                 250                 255     


Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
                325                 330                 335     


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            340                 345                 350         


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
    370                 375                 380                 


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 


<210>  224
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  224

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  225
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  225

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  226
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  226

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  227
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  227

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  228
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  228

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  229
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  229

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  230
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  231
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  231

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  232
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  232

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Phe Gly 
        195                 200                 205             


Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser Val Thr 
                245                 250                 255     


Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  233
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  233

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala 
            180                 185                 190         


Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile 
        195                 200                 205             


Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser 
                245                 250                 255     


Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  234
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  234

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Val 
                165                 170                 175     


Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly 
        195                 200                 205             


Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Val 
    210                 215                 220                 


Asp Asn Ala Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Val 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp 
                245                 250                 255     


Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  235
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  235

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                165                 170                 175     


Gly Gly Leu Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Leu Val Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn 
    210                 215                 220                 


Thr Val Phe Leu Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Arg Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser 
385                 390 


<210>  236
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  236

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala Met Ala Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Phe Gly Val Gly 
        195                 200                 205             


Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Ile Ala Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu Asn Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met Ser Ser Val Thr Arg Gly 
                245                 250                 255     


Ser Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
                325                 330                 335     


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            340                 345                 350         


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
        355                 360                 365             


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
    370                 375                 380                 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395 


<210>  237
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val Ser Pro Gly Gly 
        195                 200                 205             


Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Asn Asn Arg 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser 
385                 390 


<210>  238
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  238

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp 
        195                 200                 205             


Thr Thr Asp Tyr Ala Glu Ser Val Glu Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Thr Trp Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Met Gly 
                245                 250                 255     


Val Pro Glu Lys Arg Val Ile Met Tyr Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
305                 310                 315                 320 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                325                 330                 335     


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
        355                 360                 365             


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
    370                 375                 380                 


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 


<210>  239
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            180                 185                 190         


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        195                 200                 205             


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                245                 250                 255     


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  240
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  240

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln 
            180                 185                 190         


Gly Pro Gly Lys Asp Arg Glu Phe Val Ala Ala Ile Asp Trp Ser Asp 
        195                 200                 205             


Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp 
                245                 250                 255     


Gly Pro Met Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  241
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  241

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Gly Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  242
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  242

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  243
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  243

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Ile Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  244
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  244

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Val Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  245
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  245

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  246
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  246

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Asp Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  247
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  247

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Glu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  248
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  248

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  249
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  250
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  250

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  251
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  251

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  252
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  253
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  254
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  255
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  256
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  256

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  257
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  257

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  258
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  258

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Tyr Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  259
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  259

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  260
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  260

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Ala Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  261
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  261

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Phe Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  262
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  262

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Tyr Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  263
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  263

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  264
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  264

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Gln Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  265
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Glu Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  266
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  266

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  267
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  267

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Glu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  268
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  268

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  269
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  269

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  270
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  270

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  271
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  271

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  272
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  272

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  273
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  273

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140             


<210>  274
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  274

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140             


<210>  275
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  275

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  276
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  276

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140             


<210>  277
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  277

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140             


<210>  278
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  278

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  279
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  279

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  280
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  280

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Ser Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  281
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  281

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Ser Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  282
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  282

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Asp Trp 
    290                 295                 300                 


Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
                325                 330                 335     


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro 
            340                 345                 350         


Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser 
    370                 375     


<210>  283
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  283

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
        195                 200                 205             


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
                245                 250                 255     


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala 
                325                 330                 335     


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
            340                 345                 350         


Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
385                 390                 395                 400 


Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr Asp 
                405                 410                 415     


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425             


<210>  284
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  284

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala 
145                 150                 155                 160 


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
                165                 170                 175     


Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr Asp 
225                 230                 235                 240 


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                325                 330                 335     


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser 
    370                 375     


<210>  285
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  285

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Asp Trp Ser Glu 
        195                 200                 205             


Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp 
                245                 250                 255     


Gly Pro Leu Ile Tyr Ile Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
305                 310                 315                 320 


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
                325                 330                 335     


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
            340                 345                 350         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
        355                 360                 365             


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    370                 375                 380                 


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
385                 390                 395                 400 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
                405                 410                 415     


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425             


<210>  286
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  286

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala 
    290                 295                 300                 


Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr 
            340                 345                 350         


Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        355                 360                 365             


Val Ser Ser 
    370     


<210>  287
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  287

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
        195                 200                 205             


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
                245                 250                 255     


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala 
                325                 330                 335     


Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
            340                 345                 350         


Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu 
385                 390                 395                 400 


Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser 
            420             


<210>  288
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  288

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala 
145                 150                 155                 160 


Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
                165                 170                 175     


Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu 
    210                 215                 220                 


Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
            260                 265                 270         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
        275                 280                 285             


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
            340                 345                 350         


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
        355                 360                 365             


Val Ser Ser 
    370     


<210>  289
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  289

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly 
        195                 200                 205             


Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ser Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp 
                245                 250                 255     


Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser 
            420             


<210>  290
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  290

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser 
    290                 295                 300                 


Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser 
            340                 345                 350         


Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser 
    370             


<210>  291
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  291

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
        195                 200                 205             


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
                245                 250                 255     


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala 
                325                 330                 335     


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala 
            340                 345                 350         


Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser 
385                 390                 395                 400 


Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr Gly 
                405                 410                 415     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425 


<210>  292
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  292

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala 
145                 150                 155                 160 


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala 
                165                 170                 175     


Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser 
    210                 215                 220                 


Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        275                 280                 285             


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                325                 330                 335     


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser 
    370             


<210>  293
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  293

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp 
        195                 200                 205             


Thr Thr Asp Tyr Ala Glu Asp Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Leu Gly 
                245                 250                 255     


Val Pro Glu Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                325                 330                 335     


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
            340                 345                 350         


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
        355                 360                 365             


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
385                 390                 395                 400 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
                405                 410                 415     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425 


<210>  294
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  294

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala Gly 
            340                 345                 350         


Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    370                 375                 380                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr 
385                 390                 395                 400 


Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  295
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  295

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Glu Ile Thr Ala Gly 
            340                 345                 350         


Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    370                 375                 380                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr 
385                 390                 395                 400 


Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  296
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  296

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                165                 170                 175     


Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
            180                 185                 190         


Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  297
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  297

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                165                 170                 175     


Phe Arg Ile Asn Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
            180                 185                 190         


Arg Glu Leu Val Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Asn Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  298
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  298

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
        195                 200                 205             


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
                245                 250                 255     


Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 
            340                 345                 350         


Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser 
        355                 360                 365             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
    370                 375                 380                 


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 


Cys Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  299
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  299

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
        195                 200                 205             


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
                245                 250                 255     


Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp 
            340                 345                 350         


Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser 
        355                 360                 365             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
    370                 375                 380                 


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 


Cys Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  300
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  300

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Thr Val Ser Pro 
        195                 200                 205             


Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Gly 
                245                 250                 255     


Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  301
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  301

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val Ser Pro 
        195                 200                 205             


Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp Leu Gly 
                245                 250                 255     


Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  302
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  302

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser 
            340                 345                 350         


Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    370                 375                 380                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Leu 
385                 390                 395                 400 


Gly Val Pro Glu Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  303
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  303

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser 
            340                 345                 350         


Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    370                 375                 380                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Leu 
385                 390                 395                 400 


Gly Val Pro Glu Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  304
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  304

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu 
                165                 170                 175     


Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg 
            180                 185                 190         


Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala 
        195                 200                 205             


Glu Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn 
    210                 215                 220                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg 
                245                 250                 255     


Val Ile Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            340                 345                 350         


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
        355                 360                 365             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
    370                 375                 380                 


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  305
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  305

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu 
                165                 170                 175     


Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg 
            180                 185                 190         


Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala 
        195                 200                 205             


Glu Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn 
    210                 215                 220                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg 
                245                 250                 255     


Val Ile Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            340                 345                 350         


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
        355                 360                 365             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
    370                 375                 380                 


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  306
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  306

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
        195                 200                 205             


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
                245                 250                 255     


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
            340                 345                 350         


Glu Trp Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  307
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  307

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
        195                 200                 205             


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
                245                 250                 255     


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
            340                 345                 350         


Ala Trp Val Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  308
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  308

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Thr Val 
        195                 200                 205             


Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp 
                245                 250                 255     


Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            340                 345                 350         


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
        355                 360                 365             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
    370                 375                 380                 


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  309
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  309

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Pro Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val Ser Thr Val 
        195                 200                 205             


Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg Asp 
                245                 250                 255     


Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            340                 345                 350         


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
        355                 360                 365             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
    370                 375                 380                 


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
385                 390                 395                 400 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
                405                 410                 415     


Thr Val Ser Ser 
            420 


<210>  310
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  310

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
                245                 250                 255     


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            260                 265                 270         


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn Ala 
        275                 280                 285             


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
    290                 295                 300                 


Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Asn Thr Val Tyr Leu 
                325                 330                 335     


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr Asp 
        355                 360                 365             


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  311
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  311

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr 
145                 150                 155                 160 


Tyr Leu Asn Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Phe Val Ala Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile 
225                 230                 235                 240 


Glu Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
        355                 360                 365             


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  312
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  312

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            180                 185                 190         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys 
        275                 280                 285             


Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu 
    290                 295                 300                 


Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile 
        355                 360                 365             


Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  313
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  313

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp 
            180                 185                 190         


Tyr Ala Glu Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu 
225                 230                 235                 240 


Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
        355                 360                 365             


Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  314
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  314

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
                245                 250                 255     


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            260                 265                 270         


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala 
        275                 280                 285             


Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
    290                 295                 300                 


Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met 
            340                 345                 350         


Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser 
    370             


<210>  315
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  315

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                165                 170                 175     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    210                 215                 220                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp 
    290                 295                 300                 


Tyr Ala Glu Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
305                 310                 315                 320 


Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu 
            340                 345                 350         


Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


<210>  316
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  316

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  317
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  317

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            180                 185                 190         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys 
        275                 280                 285             


Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu 
    290                 295                 300                 


Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Asp 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile 
        355                 360                 365             


Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  318
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  318

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  319
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  319

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser 
    290                 295                 300                 


Ser Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser 
            340                 345                 350         


Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser 
    370             


<210>  320
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  320

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Gly Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                165                 170                 175     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    210                 215                 220                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Thr Leu Phe Lys Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Arg Arg Glu Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp 
    290                 295                 300                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
305                 310                 315                 320 


Trp Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu 
            340                 345                 350         


Lys Arg Val Ile Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


<210>  321
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  321

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Glu Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Leu Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            180                 185                 190         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys 
        275                 280                 285             


Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu 
    290                 295                 300                 


Leu Val Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys His Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile 
        355                 360                 365             


Leu Tyr Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  322
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  322

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Trp Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Leu Gly Val Pro Glu Lys Arg Val Ile Leu Tyr 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
                245                 250                 255     


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            260                 265                 270         


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn Ala 
        275                 280                 285             


Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
    290                 295                 300                 


Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Met 
            340                 345                 350         


Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser 
    370             


<210>  323
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  323

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        115                 120                 125             


Ala Ala His His His His His His 
    130                 135     


<210>  324
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  324

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140     


<210>  325
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  325

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  326
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  326

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His 
145             


<210>  327
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  327

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile 
        115                 120                 125             


Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    130                 135                 140             


<210>  328
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  328
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggattggt gcaggctggg      300

ggctctctga gactctcctg tgcagcctct ggacgcacgt actatctcaa tgccatgggc      360

tggttccgcc agggtccagg gaaggaccgt gagtttgtag cagctataga ctggagtgat      420

ggtaacaaag actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      540

tgtgcagccg acacaccacc ctgggggcct atgatctaca tcgaatcgta tgactcctgg      600

ggccagggga ccctggtcac ggtctcctcc ggaggcggtg ggtcaggtgg cggaggcagc      660

ggtggaggag gtagtggcgg tggcggtagt gggggtggag gcagcggagg cggaggcagt      720

gggggcggtg gatccgaggt gcagttggtg gagtctgggg gaggattggt gcaggctggg      780

ggctctctga gactctcctg tgcagcctct ggacgcacgt actatctcaa tgccatgggc      840

tggttccgcc agggtccagg gaaggaccgt gagtttgtag cagctataga ctggagtgat      900

ggtaacaaag actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      960

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac     1020

tgtgcagccg acacaccacc ctgggggcct atgatctaca tcgaatcgta tgactcctgg     1080

ggccagggga ccctggtcac ggtctcgagc ggagggggag gtagtggggg tggctcagag     1140

gtacaactag tggagtctgg gggtggcttg gtgcaaccgg gtaacagtct gcgccttagc     1200

tgcgcagcgt ctggctttac cttcagctcc tttggcatga gctgggttcg ccaggctccg     1260

ggaaaaggac tggaatgggt ttcgtctatt agcggcagtg gtagcgatac gctctacgcg     1320

gactccgtga agggccgttt caccatctcc cgcgataacg ccaaaactac actgtatctg     1380

caaatgaata gcctgcgtcc tgaagacacg gccgtttatt actgtactat tggtggctcg     1440

ttaagccgtt cttcacaggg taccctggtc accgtctcct ca                        1482


<210>  329
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  329
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggattggt gcaggctggg      300

ggctctctga gactctcctg tgcagcctct ggacgcacgt actatctcaa tgccatgggc      360

tggttccgcc agggtccagg gaaggaccgt gagtttgtag cagctataga ctggagtgat      420

ggtaacaaag actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      540

tgtgcagccg acacaccacc ctgggggcct atgatctaca tcgaatcgta tgactcctgg      600

ggccagggga ccctggtcac ggtctcctcc ggaggcggtg ggtcaggtgg cggaggcagc      660

ggtggaggag gtagtggcgg tggcggtagt gggggtggag gcagcggagg cggaggcagt      720

gggggcggtg gatccgaggt gcagttggtg gagtctgggg gaggcttggt gcagcctggg      780

gggtctctgg gactctcctg tgtagcctct ggaagcatct tcagaatcaa tgccatggcc      840

tggtaccgcc aggctccagg gaagcagcgc gagttggtcg cggaaattac tgctggtggt      900

agcacaaact atgcagactc cgtgaagggc cgattcacca tctccgtaga caacgcctgg      960

aacacgctgt atctgcaaat gaacagcctg aaagttgagg acacggccgt ctattactgt     1020

aatctagatc attatacgac atgggataga cggagtgcct actggggcca ggggaccctg     1080

gtcacggtct cgagcggagg gggaggtagt gggggtggct cagaggtaca actagtggag     1140

tctgggggtg gcttggtgca accgggtaac agtctgcgcc ttagctgcgc agcgtctggc     1200

tttaccttca gctcctttgg catgagctgg gttcgccagg ctccgggaaa aggactggaa     1260

tgggtttcgt ctattagcgg cagtggtagc gatacgctct acgcggactc cgtgaagggc     1320

cgtttcacca tctcccgcga taacgccaaa actacactgt atctgcaaat gaatagcctg     1380

cgtcctgaag acacggccgt ttattactgt actattggtg gctcgttaag ccgttcttca     1440

cagggtaccc tggtcaccgt ctcctca                                         1467


<210>  330
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  330
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggattggt gcaggctggg      300

ggctctctga gactctcctg tgcagcctct ggacgcacgt actatctcaa tgccatgggc      360

tggttccgcc agggtccagg gaaggaccgt gagtttgtag cagctataga ctggagtgat      420

ggtaacaaag actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      540

tgtgcagccg acacaccacc ctgggggcct atgatctaca tcgaatcgta tgactcctgg      600

ggccagggga ccctggtcac ggtctcctcc ggaggcggtg ggtcaggtgg cggaggcagc      660

ggtggaggag gtagtggcgg tggcggtagt gggggtggag gcagcggagg cggaggcagt      720

gggggcggtg gatccgaggt gcagttggtg gagtctgggg gaggcttggt gcaggctggg      780

gggtctctga gactctcctg tgcagcctct ggattcacct tcagtagcta tcccatgagc      840

tgggtccgcc aggctccagg aaaggggccc gcgtgggtct caactgttag tcctggtggt      900

ataaccacaa gctatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      960

aagaacacgc tgtatttgca aatgaacagc ctgaaacctg aggacacggc cgtgtattac     1020

tgcttaagag atctgaataa taggggccag gggaccctgg tcacggtctc gagcggaggg     1080

ggaggtagtg ggggtggctc agaggtacaa ctagtggagt ctgggggtgg cttggtgcaa     1140

ccgggtaaca gtctgcgcct tagctgcgca gcgtctggct ttaccttcag ctcctttggc     1200

atgagctggg ttcgccaggc tccgggaaaa ggactggaat gggtttcgtc tattagcggc     1260

agtggtagcg atacgctcta cgcggactcc gtgaagggcc gtttcaccat ctcccgcgat     1320

aacgccaaaa ctacactgta tctgcaaatg aatagcctgc gtcctgaaga cacggccgtt     1380

tattactgta ctattggtgg ctcgttaagc cgttcttcac agggtaccct ggtcaccgtc     1440

tcctca                                                                1446


<210>  331
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  331
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctgg gactctcctg tgtagcctct ggaagcatct tcagaatcaa tgccatggcc      360

tggtaccgcc aggctccagg gaagcagcgc gagttggtcg cggaaattac tgctggtggt      420

agcacaaact atgcagactc cgtgaagggc cgattcacca tctccgtaga caacgcctgg      480

aacacgctgt atctgcaaat gaacagcctg aaagttgagg acacggccgt ctattactgt      540

aatctagatc attatacgac atgggataga cggagtgcct actggggcca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc      780

tcctgtgcag cctctggacg cacgtactat ctcaatgcca tgggctggtt ccgccagggt      840

ccagggaagg accgtgagtt tgtagcagct atagactgga gtgatggtaa caaagactat      900

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      960

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agccgacaca     1020

ccaccctggg ggcctatgat ctacatcgaa tcgtatgact cctggggcca ggggaccctg     1080

gtcacggtct cgagcggagg gggaggtagt gggggtggct cagaggtaca actagtggag     1140

tctgggggtg gcttggtgca accgggtaac agtctgcgcc ttagctgcgc agcgtctggc     1200

tttaccttca gctcctttgg catgagctgg gttcgccagg ctccgggaaa aggactggaa     1260

tgggtttcgt ctattagcgg cagtggtagc gatacgctct acgcggactc cgtgaagggc     1320

cgtttcacca tctcccgcga taacgccaaa actacactgt atctgcaaat gaatagcctg     1380

cgtcctgaag acacggccgt ttattactgt actattggtg gctcgttaag ccgttcttca     1440

cagggtaccc tggtcaccgt ctcctca                                         1467


<210>  332
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  332
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctgg gactctcctg tgtagcctct ggaagcatct tcagaatcaa tgccatggcc      360

tggtaccgcc aggctccagg gaagcagcgc gagttggtcg cggaaattac tgctggtggt      420

agcacaaact atgcagactc cgtgaagggc cgattcacca tctccgtaga caacgcctgg      480

aacacgctgt atctgcaaat gaacagcctg aaagttgagg acacggccgt ctattactgt      540

aatctagatc attatacgac atgggataga cggagtgcct actggggcca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc      780

tcctgtgcag cctctggatt caccttcagt agctatccca tgagctgggt ccgccaggct      840

ccaggaaagg ggcccgcgtg ggtctcaact gttagtcctg gtggtataac cacaagctat      900

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      960

ttgcaaatga acagcctgaa acctgaggac acggccgtgt attactgctt aagagatctg     1020

aataataggg gccaggggac cctggtcacg gtctcgagcg gagggggagg tagtgggggt     1080

ggctcagagg tacaactagt ggagtctggg ggtggcttgg tgcaaccggg taacagtctg     1140

cgccttagct gcgcagcgtc tggctttacc ttcagctcct ttggcatgag ctgggttcgc     1200

caggctccgg gaaaaggact ggaatgggtt tcgtctatta gcggcagtgg tagcgatacg     1260

ctctacgcgg actccgtgaa gggccgtttc accatctccc gcgataacgc caaaactaca     1320

ctgtatctgc aaatgaatag cctgcgtcct gaagacacgg ccgtttatta ctgtactatt     1380

ggtggctcgt taagccgttc ttcacagggt accctggtca ccgtctcctc a              1431


<210>  333
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  333
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaggctggg      300

gggtctctga gactctcctg tgcagcctct ggattcacct tcagtagcta tcccatgagc      360

tgggtccgcc aggctccagg aaaggggccc gcgtgggtct caactgttag tcctggtggt      420

ataaccacaa gctatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgc tgtatttgca aatgaacagc ctgaaacctg aggacacggc cgtgtattac      540

tgcttaagag atctgaataa taggggccag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggaggat tggtgcaggc tgggggctct ctgagactct cctgtgcagc ctctggacgc      780

acgtactatc tcaatgccat gggctggttc cgccagggtc cagggaagga ccgtgagttt      840

gtagcagcta tagactggag tgatggtaac aaagactatg cagactccgt gaagggccga      900

ttcaccatct ccagagacaa cgccaagaac acggtgtatc tgcaaatgaa cagcctgaaa      960

cctgaggaca cggccgttta ttactgtgca gccgacacac caccctgggg gcctatgatc     1020

tacatcgaat cgtatgactc ctggggccag gggaccctgg tcacggtctc gagcggaggg     1080

ggaggtagtg ggggtggctc agaggtacaa ctagtggagt ctgggggtgg cttggtgcaa     1140

ccgggtaaca gtctgcgcct tagctgcgca gcgtctggct ttaccttcag ctcctttggc     1200

atgagctggg ttcgccaggc tccgggaaaa ggactggaat gggtttcgtc tattagcggc     1260

agtggtagcg atacgctcta cgcggactcc gtgaagggcc gtttcaccat ctcccgcgat     1320

aacgccaaaa ctacactgta tctgcaaatg aatagcctgc gtcctgaaga cacggccgtt     1380

tattactgta ctattggtgg ctcgttaagc cgttcttcac agggtaccct ggtcaccgtc     1440

tcctca                                                                1446


<210>  334
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  334
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaggctggg      300

gggtctctga gactctcctg tgcagcctct ggattcacct tcagtagcta tcccatgagc      360

tgggtccgcc aggctccagg aaaggggccc gcgtgggtct caactgttag tcctggtggt      420

ataaccacaa gctatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgc tgtatttgca aatgaacagc ctgaaacctg aggacacggc cgtgtattac      540

tgcttaagag atctgaataa taggggccag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggaggct tggtgcagcc tggggggtct ctgggactct cctgtgtagc ctctggaagc      780

atcttcagaa tcaatgccat ggcctggtac cgccaggctc cagggaagca gcgcgagttg      840

gtcgcggaaa ttactgctgg tggtagcaca aactatgcag actccgtgaa gggccgattc      900

accatctccg tagacaacgc ctggaacacg ctgtatctgc aaatgaacag cctgaaagtt      960

gaggacacgg ccgtctatta ctgtaatcta gatcattata cgacatggga tagacggagt     1020

gcctactggg gccaggggac cctggtcacg gtctcgagcg gagggggagg tagtgggggt     1080

ggctcagagg tacaactagt ggagtctggg ggtggcttgg tgcaaccggg taacagtctg     1140

cgccttagct gcgcagcgtc tggctttacc ttcagctcct ttggcatgag ctgggttcgc     1200

caggctccgg gaaaaggact ggaatgggtt tcgtctatta gcggcagtgg tagcgatacg     1260

ctctacgcgg actccgtgaa gggccgtttc accatctccc gcgataacgc caaaactaca     1320

ctgtatctgc aaatgaatag cctgcgtcct gaagacacgg ccgtttatta ctgtactatt     1380

ggtggctcgt taagccgttc ttcacagggt accctggtca ccgtctcctc a              1431


<210>  335
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  335
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaggctggg      300

gggtctctga gactctcctg tgcagcctct ggattcacct tcagtagcta tcccatgagc      360

tgggtccgcc aggctccagg aaaggggccc gcgtgggtct caactgttag tcctggtggt      420

ataaccacaa gctatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgc tgtatttgca aatgaacagc ctgaaacctg aggacacggc cgtgtattac      540

tgcttaagag atctgaataa taggggccag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggaggct tggtgcaggc tggggggtct ctgagactct cctgtgcagc ctctggattc      780

accttcagta gctatcccat gagctgggtc cgccaggctc caggaaaggg gcccgcgtgg      840

gtctcaactg ttagtcctgg tggtataacc acaagctatg cagactccgt gaagggccga      900

ttcaccatct ccagagacaa cgccaagaac acgctgtatt tgcaaatgaa cagcctgaaa      960

cctgaggaca cggccgtgta ttactgctta agagatctga ataatagggg ccaggggacc     1020

ctggtcacgg tctcgagcgg agggggaggt agtgggggtg gctcagaggt acaactagtg     1080

gagtctgggg gtggcttggt gcaaccgggt aacagtctgc gccttagctg cgcagcgtct     1140

ggctttacct tcagctcctt tggcatgagc tgggttcgcc aggctccggg aaaaggactg     1200

gaatgggttt cgtctattag cggcagtggt agcgatacgc tctacgcgga ctccgtgaag     1260

ggccgtttca ccatctcccg cgataacgcc aaaactacac tgtatctgca aatgaatagc     1320

ctgcgtcctg aagacacggc cgtttattac tgtactattg gtggctcgtt aagccgttct     1380

tcacagggta ccctggtcac cgtctcctca                                      1410


<210>  336
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  336
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggattggt gcaggctggg      300

ggctctctga gactctcctg tgcagcctct ggacgcacgt actatctcaa tgccatgggc      360

tggttccgcc agggtccagg gaaggaccgt gagtttgtag cagctataga ctggagtgat      420

ggtaacaaag actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      540

tgtgcagccg acacaccacc ctgggggcct atgatctaca tcgaatcgta tgactcctgg      600

ggccagggga ccctggtcac ggtctcctcc ggaggcggtg ggtcaggtgg cggaggcagc      660

ggtggaggag gtagtggcgg tggcggtagt gggggtggag gcagcggagg cggaggcagt      720

gggggcggtg gatccgaggt gcagttggtg gagtctgggg gaggcttggt gcagcctggg      780

gggtctctga gactctcctg tgcagcctct ggaacgctct tcaaaatcaa cgccatgggc      840

tggtaccgcc aggctccagg gaagcggcgc gagttggtcg cacttattac tagtagcgat      900

acaacggatt atgcagagtc cgtggagggc cgattcacca tctccagaga caacacgtgg      960

aacgcggtgt atctgcaaat gaacagtctg aaacctgagg atacggccgt ctattactgt     1020

cactcagatc attactcgat gggtgtgcct gaaaagcgag tcataatgta cggccagggg     1080

accctggtca cggtctcgag cggaggggga ggtagtgggg gtggctcaga ggtacaacta     1140

gtggagtctg ggggtggctt ggtgcaaccg ggtaacagtc tgcgccttag ctgcgcagcg     1200

tctggcttta ccttcagctc ctttggcatg agctgggttc gccaggctcc gggaaaagga     1260

ctggaatggg tttcgtctat tagcggcagt ggtagcgata cgctctacgc ggactccgtg     1320

aagggccgtt tcaccatctc ccgcgataac gccaaaacta cactgtatct gcaaatgaat     1380

agcctgcgtc ctgaagacac ggccgtttat tactgtacta ttggtggctc gttaagccgt     1440

tcttcacagg gtaccctggt caccgtctcc tca                                  1473


<210>  337
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  337
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaggctggg      300

gggtctctga gactctcctg tgcagcctct ggattcacct tcagtagcta tcccatgagc      360

tgggtccgcc aggctccagg aaaggggccc gcgtgggtct caactgttag tcctggtggt      420

ataaccacaa gctatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgc tgtatttgca aatgaacagc ctgaaacctg aggacacggc cgtgtattac      540

tgcttaagag atctgaataa taggggccag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggaggct tggtgcagcc tggggggtct ctgagactct cctgtgcagc ctctggaacg      780

ctcttcaaaa tcaacgccat gggctggtac cgccaggctc cagggaagcg gcgcgagttg      840

gtcgcactta ttactagtag cgatacaacg gattatgcag agtccgtgga gggccgattc      900

accatctcca gagacaacac gtggaacgcg gtgtatctgc aaatgaacag tctgaaacct      960

gaggatacgg ccgtctatta ctgtcactca gatcattact cgatgggtgt gcctgaaaag     1020

cgagtcataa tgtacggcca ggggaccctg gtcacggtct cgagcggagg gggaggtagt     1080

gggggtggct cagaggtaca actagtggag tctgggggtg gcttggtgca accgggtaac     1140

agtctgcgcc ttagctgcgc agcgtctggc tttaccttca gctcctttgg catgagctgg     1200

gttcgccagg ctccgggaaa aggactggaa tgggtttcgt ctattagcgg cagtggtagc     1260

gatacgctct acgcggactc cgtgaagggc cgtttcacca tctcccgcga taacgccaaa     1320

actacactgt atctgcaaat gaatagcctg cgtcctgaag acacggccgt ttattactgt     1380

actattggtg gctcgttaag ccgttcttca cagggtaccc tggtcaccgt ctcctca        1437


<210>  338
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  338
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctga gactctcctg tgcagcctct ggaacgctct tcaaaatcaa cgccatgggc      360

tggtaccgcc aggctccagg gaagcggcgc gagttggtcg cacttattac tagtagcgat      420

acaacggatt atgcagagtc cgtggagggc cgattcacca tctccagaga caacacgtgg      480

aacgcggtgt atctgcaaat gaacagtctg aaacctgagg atacggccgt ctattactgt      540

cactcagatc attactcgat gggtgtgcct gaaaagcgag tcataatgta cggccagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg      780

agactctcct gtgcagcctc tggaacgctc ttcaaaatca acgccatggg ctggtaccgc      840

caggctccag ggaagcggcg cgagttggtc gcacttatta ctagtagcga tacaacggat      900

tatgcagagt ccgtggaggg ccgattcacc atctccagag acaacacgtg gaacgcggtg      960

tatctgcaaa tgaacagtct gaaacctgag gatacggccg tctattactg tcactcagat     1020

cattactcga tgggtgtgcc tgaaaagcga gtcataatgt acggccaggg gaccctggtc     1080

acggtctcga gcggaggggg aggtagtggg ggtggctcag aggtacaact agtggagtct     1140

gggggtggct tggtgcaacc gggtaacagt ctgcgcctta gctgcgcagc gtctggcttt     1200

accttcagct cctttggcat gagctgggtt cgccaggctc cgggaaaagg actggaatgg     1260

gtttcgtcta ttagcggcag tggtagcgat acgctctacg cggactccgt gaagggccgt     1320

ttcaccatct cccgcgataa cgccaaaact acactgtatc tgcaaatgaa tagcctgcgt     1380

cctgaagaca cggccgttta ttactgtact attggtggct cgttaagccg ttcttcacag     1440

ggtaccctgg tcaccgtctc ctca                                            1464


<210>  339
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  339
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctga gactctcctg tgcagcctct ggaacgctct tcaaaatcaa cgccatgggc      360

tggtaccgcc aggctccagg gaagcggcgc gagttggtcg cacttattac tagtagcgat      420

acaacggatt atgcagagtc cgtggagggc cgattcacca tctccagaga caacacgtgg      480

aacgcggtgt atctgcaaat gaacagtctg aaacctgagg atacggccgt ctattactgt      540

cactcagatc attactcgat gggtgtgcct gaaaagcgag tcataatgta cggccagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggaggattgg tgcaggctgg gggctctctg      780

agactctcct gtgcagcctc tggacgcacg tactatctca atgccatggg ctggttccgc      840

cagggtccag ggaaggaccg tgagtttgta gcagctatag actggagtga tggtaacaaa      900

gactatgcag actccgtgaa gggccgattc accatctcca gagacaacgc caagaacacg      960

gtgtatctgc aaatgaacag cctgaaacct gaggacacgg ccgtttatta ctgtgcagcc     1020

gacacaccac cctgggggcc tatgatctac atcgaatcgt atgactcctg gggccagggg     1080

accctggtca cggtctcgag cggaggggga ggtagtgggg gtggctcaga ggtacaacta     1140

gtggagtctg ggggtggctt ggtgcaaccg ggtaacagtc tgcgccttag ctgcgcagcg     1200

tctggcttta ccttcagctc ctttggcatg agctgggttc gccaggctcc gggaaaagga     1260

ctggaatggg tttcgtctat tagcggcagt ggtagcgata cgctctacgc ggactccgtg     1320

aagggccgtt tcaccatctc ccgcgataac gccaaaacta cactgtatct gcaaatgaat     1380

agcctgcgtc ctgaagacac ggccgtttat tactgtacta ttggtggctc gttaagccgt     1440

tcttcacagg gtaccctggt caccgtctcc tca                                  1473


<210>  340
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  340
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctga gactctcctg tgcagcctct ggaacgctct tcaaaatcaa cgccatgggc      360

tggtaccgcc aggctccagg gaagcggcgc gagttggtcg cacttattac tagtagcgat      420

acaacggatt atgcagagtc cgtggagggc cgattcacca tctccagaga caacacgtgg      480

aacgcggtgt atctgcaaat gaacagtctg aaacctgagg atacggccgt ctattactgt      540

cactcagatc attactcgat gggtgtgcct gaaaagcgag tcataatgta cggccagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggaggcttgg tgcaggctgg ggggtctctg      780

agactctcct gtgcagcctc tggattcacc ttcagtagct atcccatgag ctgggtccgc      840

caggctccag gaaaggggcc cgcgtgggtc tcaactgtta gtcctggtgg tataaccaca      900

agctatgcag actccgtgaa gggccgattc accatctcca gagacaacgc caagaacacg      960

ctgtatttgc aaatgaacag cctgaaacct gaggacacgg ccgtgtatta ctgcttaaga     1020

gatctgaata ataggggcca ggggaccctg gtcacggtct cgagcggagg gggaggtagt     1080

gggggtggct cagaggtaca actagtggag tctgggggtg gcttggtgca accgggtaac     1140

agtctgcgcc ttagctgcgc agcgtctggc tttaccttca gctcctttgg catgagctgg     1200

gttcgccagg ctccgggaaa aggactggaa tgggtttcgt ctattagcgg cagtggtagc     1260

gatacgctct acgcggactc cgtgaagggc cgtttcacca tctcccgcga taacgccaaa     1320

actacactgt atctgcaaat gaatagcctg cgtcctgaag acacggccgt ttattactgt     1380

actattggtg gctcgttaag ccgttcttca cagggtaccc tggtcaccgt ctcctca        1437


<210>  341
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  341
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagtctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtccggc atgggttagc accgttagtc cgggaggtat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg acaatagcaa aaacaccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tctgcgcgat      360

ctgaataatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  342
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  342
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtcctga atgggttagc accgttagtc cgggaggtat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg acaatagcaa aaacaccctg      300

tatctgcaga tgaatagtct gcgtcctgaa gataccgcag tttattattg tctgcgcgat      360

ctgaataatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  343
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  343
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagtctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtccggc atgggttagc accgttagtc cgggaggtat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg acaatagcaa aaacaccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tgcacgcgat      360

ctgaataatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  344
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  344
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagtctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtcctga atgggttagc accgttagtc cgggaggtat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg acaatagcaa aaacaccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tgcacgcgat      360

ctgaataatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  345
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  345
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tcgtacctat tatctgaatg caatgggttg gtttcgtcag      180

ggtccgggta aagatcgtga atttgttgca gccattgatt ggagtgatgg caataaagat      240

tatgccgata gcgtgaaagg tcgttttacc attagccgtg ataacagcaa aaacaccgtt      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tgcagcagat      360

acccctccgt ggggtccgat gatttatatt gaaagctatg atagctgggg tcaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  346
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  346
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tcgtacctat tatctgaatg caatgggttg gtttcgtcag      180

gcaccgggta aagatcgtga atttgttgca gccattgatt ggagtgatgg caataaagat      240

tatgccgata gcgtgaaagg tcgttttacc attagccgtg ataacagcaa aaacaccgtt      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tgcagcagat      360

acccctccgt ggggtccgat gatttatatt gaaagctatg atagctgggg tcaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  347
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  347
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tcgtacctat tatctgaatg caatgggttg gtttcgtcag      180

ggtccgggta aagaacgtga atttgttgca gccattgatt ggagtgatgg caataaagat      240

tatgccgata gcgtgaaagg tcgttttacc attagccgtg ataacagcaa aaacaccgtt      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tgcagcagat      360

acccctccgt ggggtccgat gatttatatt gaaagctatg atagctgggg tcaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  348
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  348
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tcgtacctat tatctgaatg caatgggttg gtttcgtcag      180

gcaccgggta aagaacgtga atttgttgca gccattgatt ggagtgatgg caataaagat      240

tatgccgata gcgtgaaagg tcgttttacc attagccgtg ataacagcaa aaacaccgtt      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tgcagcagat      360

acccctccgt ggggtccgat gatttatatt gaaagctatg atagctgggg tcaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  349
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  349
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctgg gactctcctg tgtagcctct ggaagcatct tcagaatcaa tgccatggcc      360

tggtaccgcc aggctccagg gaagcagcgc gagttggtcg cggaaattac tgctggtggt      420

agcacaaact atgcagactc cgtgaagggc cgattcacca tctccgtaga caacgcctgg      480

aacacgctgt atctgcaaat gaacagcctg aaagttgagg acacggccgt ctattactgt      540

aatctagatc attatacgac atgggataga cggagtgcct actggggcca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggaggc ttggtgcaac ctggggggtc tctgagactc      780

tcctgcgcag cctctggaag catcggcggt ctcaatgcca tggcctggta ccgccaggct      840

ccaggaaaag agcgcgagtt ggtcgcaggt atttttggcg ttggtagcac gaggtacgcg      900

gactccgtga agggccgatt caccatctct agagacatcg ccaagaacac ggtgtttctg      960

caaatgaaca gcctgaattc tgaggacacg gccgtttatt actgtcggat gtcaagtgtt     1020

actcgtggta gttctgacta ctggggtcag gggaccctgg tcacggtctc gagcggaggg     1080

ggaggtagtg ggggtggctc agaggtacaa ctagtggagt ctgggggtgg cttggtgcaa     1140

ccgggtaaca gtctgcgcct tagctgcgca gcgtctggct ttaccttcag ctcctttggc     1200

atgagctggg ttcgccaggc tccgggaaaa ggactggaat gggtttcgtc tattagcggc     1260

agtggtagcg atacgctcta cgcggactcc gtgaagggcc gtttcaccat ctcccgcgat     1320

aacgccaaaa ctacactgta tctgcaaatg aatagcctgc gtcctgaaga cacggccgtt     1380

tattactgta ctattggtgg ctcgttaagc cgttcttcac agggtaccct ggtcaccgtc     1440

tcctca                                                                1446


<210>  350
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  350
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcagcctggg      300

gggtctctga gactctcctg tgcagcctct ggaacgctct tcaaaatcaa cgccatgggc      360

tggtaccgcc aggctccagg gaagcggcgc gagttggtcg cacttattac tagtagcgat      420

acaacggatt atgcagagtc cgtggagggc cgattcacca tctccagaga caacacgtgg      480

aacgcggtgt atctgcaaat gaacagtctg aaacctgagg atacggccgt ctattactgt      540

cactcagatc attactcgat gggtgtgcct gaaaagcgag tcataatgta cggccagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggaggcttgg tgcaacctgg ggggtctctg      780

agactctcct gcgcagcctc tggaagcatc ggcggtctca atgccatggc ctggtaccgc      840

caggctccag gaaaagagcg cgagttggtc gcaggtattt ttggcgttgg tagcacgagg      900

tacgcggact ccgtgaaggg ccgattcacc atctctagag acatcgccaa gaacacggtg      960

tttctgcaaa tgaacagcct gaattctgag gacacggccg tttattactg tcggatgtca     1020

agtgttactc gtggtagttc tgactactgg ggtcagggga ccctggtcac ggtctcgagc     1080

ggagggggag gtagtggggg tggctcagag gtacaactag tggagtctgg gggtggcttg     1140

gtgcaaccgg gtaacagtct gcgccttagc tgcgcagcgt ctggctttac cttcagctcc     1200

tttggcatga gctgggttcg ccaggctccg ggaaaaggac tggaatgggt ttcgtctatt     1260

agcggcagtg gtagcgatac gctctacgcg gactccgtga agggccgttt caccatctcc     1320

cgcgataacg ccaaaactac actgtatctg caaatgaata gcctgcgtcc tgaagacacg     1380

gccgtttatt actgtactat tggtggctcg ttaagccgtt cttcacaggg taccctggtc     1440

accgtctcct ca                                                         1452


<210>  351
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  351
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaacctggg      300

gggtctctga gactctcctg cgcagcctct ggaagcatcg gcggtctcaa tgccatggcc      360

tggtaccgcc aggctccagg aaaagagcgc gagttggtcg caggtatttt tggcgttggt      420

agcacgaggt acgcggactc cgtgaagggc cgattcacca tctctagaga catcgccaag      480

aacacggtgt ttctgcaaat gaacagcctg aattctgagg acacggccgt ttattactgt      540

cggatgtcaa gtgttactcg tggtagttct gactactggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg aggcttggtg cagcctgggg ggtctctggg actctcctgt      780

gtagcctctg gaagcatctt cagaatcaat gccatggcct ggtaccgcca ggctccaggg      840

aagcagcgcg agttggtcgc ggaaattact gctggtggta gcacaaacta tgcagactcc      900

gtgaagggcc gattcaccat ctccgtagac aacgcctgga acacgctgta tctgcaaatg      960

aacagcctga aagttgagga cacggccgtc tattactgta atctagatca ttatacgaca     1020

tgggatagac ggagtgccta ctggggccag gggaccctgg tcacggtctc gagcggaggg     1080

ggaggtagtg ggggtggctc agaggtacaa ctagtggagt ctgggggtgg cttggtgcaa     1140

ccgggtaaca gtctgcgcct tagctgcgca gcgtctggct ttaccttcag ctcctttggc     1200

atgagctggg ttcgccaggc tccgggaaaa ggactggaat gggtttcgtc tattagcggc     1260

agtggtagcg atacgctcta cgcggactcc gtgaagggcc gtttcaccat ctcccgcgat     1320

aacgccaaaa ctacactgta tctgcaaatg aatagcctgc gtcctgaaga cacggccgtt     1380

tattactgta ctattggtgg ctcgttaagc cgttcttcac agggtaccct ggtcaccgtc     1440

tcctca                                                                1446


<210>  352
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  352
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaggctggg      300

gggtctctga gactctcctg tgcagcctct ggattcacct tcagtagcta tcccatgagc      360

tgggtccgcc aggctccagg aaaggggccc gcgtgggtct caactgttag tcctggtggt      420

ataaccacaa gctatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgc tgtatttgca aatgaacagc ctgaaacctg aggacacggc cgtgtattac      540

tgcttaagag atctgaataa taggggccag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggaggct tggtgcaacc tggggggtct ctgagactct cctgcgcagc ctctggaagc      780

atcggcggtc tcaatgccat ggcctggtac cgccaggctc caggaaaaga gcgcgagttg      840

gtcgcaggta tttttggcgt tggtagcacg aggtacgcgg actccgtgaa gggccgattc      900

accatctcta gagacatcgc caagaacacg gtgtttctgc aaatgaacag cctgaattct      960

gaggacacgg ccgtttatta ctgtcggatg tcaagtgtta ctcgtggtag ttctgactac     1020

tggggtcagg ggaccctggt cacggtctcg agcggagggg gaggtagtgg gggtggctca     1080

gaggtacaac tagtggagtc tgggggtggc ttggtgcaac cgggtaacag tctgcgcctt     1140

agctgcgcag cgtctggctt taccttcagc tcctttggca tgagctgggt tcgccaggct     1200

ccgggaaaag gactggaatg ggtttcgtct attagcggca gtggtagcga tacgctctac     1260

gcggactccg tgaagggccg tttcaccatc tcccgcgata acgccaaaac tacactgtat     1320

ctgcaaatga atagcctgcg tcctgaagac acggccgttt attactgtac tattggtggc     1380

tcgttaagcc gttcttcaca gggtaccctg gtcaccgtct cctca                     1425


<210>  353
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  353
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaacctggg      300

gggtctctga gactctcctg cgcagcctct ggaagcatcg gcggtctcaa tgccatggcc      360

tggtaccgcc aggctccagg aaaagagcgc gagttggtcg caggtatttt tggcgttggt      420

agcacgaggt acgcggactc cgtgaagggc cgattcacca tctctagaga catcgccaag      480

aacacggtgt ttctgcaaat gaacagcctg aattctgagg acacggccgt ttattactgt      540

cggatgtcaa gtgttactcg tggtagttct gactactggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg aggcttggtg caacctgggg ggtctctgag actctcctgc      780

gcagcctctg gaagcatcgg cggtctcaat gccatggcct ggtaccgcca ggctccagga      840

aaagagcgcg agttggtcgc aggtattttt ggcgttggta gcacgaggta cgcggactcc      900

gtgaagggcc gattcaccat ctctagagac atcgccaaga acacggtgtt tctgcaaatg      960

aacagcctga attctgagga cacggccgtt tattactgtc ggatgtcaag tgttactcgt     1020

ggtagttctg actactgggg tcaggggacc ctggtcacgg tctcgagcgg agggggaggt     1080

agtgggggtg gctcagaggt acaactagtg gagtctgggg gtggcttggt gcaaccgggt     1140

aacagtctgc gccttagctg cgcagcgtct ggctttacct tcagctcctt tggcatgagc     1200

tgggttcgcc aggctccggg aaaaggactg gaatgggttt cgtctattag cggcagtggt     1260

agcgatacgc tctacgcgga ctccgtgaag ggccgtttca ccatctcccg cgataacgcc     1320

aaaactacac tgtatctgca aatgaatagc ctgcgtcctg aagacacggc cgtttattac     1380

tgtactattg gtggctcgtt aagccgttct tcacagggta ccctggtcac cgtctcctca     1440


<210>  354
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  354
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaacctggg      300

gggtctctga gactctcctg cgcagcctct ggaagcatcg gcggtctcaa tgccatggcc      360

tggtaccgcc aggctccagg aaaagagcgc gagttggtcg caggtatttt tggcgttggt      420

agcacgaggt acgcggactc cgtgaagggc cgattcacca tctctagaga catcgccaag      480

aacacggtgt ttctgcaaat gaacagcctg aattctgagg acacggccgt ttattactgt      540

cggatgtcaa gtgttactcg tggtagttct gactactggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg aggcttggtg caggctgggg ggtctctgag actctcctgt      780

gcagcctctg gattcacctt cagtagctat cccatgagct gggtccgcca ggctccagga      840

aaggggcccg cgtgggtctc aactgttagt cctggtggta taaccacaag ctatgcagac      900

tccgtgaagg gccgattcac catctccaga gacaacgcca agaacacgct gtatttgcaa      960

atgaacagcc tgaaacctga ggacacggcc gtgtattact gcttaagaga tctgaataat     1020

aggggccagg ggaccctggt cacggtctcg agcggagggg gaggtagtgg gggtggctca     1080

gaggtacaac tagtggagtc tgggggtggc ttggtgcaac cgggtaacag tctgcgcctt     1140

agctgcgcag cgtctggctt taccttcagc tcctttggca tgagctgggt tcgccaggct     1200

ccgggaaaag gactggaatg ggtttcgtct attagcggca gtggtagcga tacgctctac     1260

gcggactccg tgaagggccg tttcaccatc tcccgcgata acgccaaaac tacactgtat     1320

ctgcaaatga atagcctgcg tcctgaagac acggccgttt attactgtac tattggtggc     1380

tcgttaagcc gttcttcaca gggtaccctg gtcaccgtct cctca                     1425


<210>  355
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  355
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaacctggg      300

gggtctctga gactctcctg cgcagcctct ggaagcatcg gcggtctcaa tgccatggcc      360

tggtaccgcc aggctccagg aaaagagcgc gagttggtcg caggtatttt tggcgttggt      420

agcacgaggt acgcggactc cgtgaagggc cgattcacca tctctagaga catcgccaag      480

aacacggtgt ttctgcaaat gaacagcctg aattctgagg acacggccgt ttattactgt      540

cggatgtcaa gtgttactcg tggtagttct gactactggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg aggcttggtg cagcctgggg ggtctctgag actctcctgt      780

gcagcctctg gaacgctctt caaaatcaac gccatgggct ggtaccgcca ggctccaggg      840

aagcggcgcg agttggtcgc acttattact agtagcgata caacggatta tgcagagtcc      900

gtggagggcc gattcaccat ctccagagac aacacgtgga acgcggtgta tctgcaaatg      960

aacagtctga aacctgagga tacggccgtc tattactgtc actcagatca ttactcgatg     1020

ggtgtgcctg aaaagcgagt cataatgtac ggccagggga ccctggtcac ggtctcgagc     1080

ggagggggag gtagtggggg tggctcagag gtacaactag tggagtctgg gggtggcttg     1140

gtgcaaccgg gtaacagtct gcgccttagc tgcgcagcgt ctggctttac cttcagctcc     1200

tttggcatga gctgggttcg ccaggctccg ggaaaaggac tggaatgggt ttcgtctatt     1260

agcggcagtg gtagcgatac gctctacgcg gactccgtga agggccgttt caccatctcc     1320

cgcgataacg ccaaaactac actgtatctg caaatgaata gcctgcgtcc tgaagacacg     1380

gccgtttatt actgtactat tggtggctcg ttaagccgtt cttcacaggg taccctggtc     1440

accgtctcct ca                                                         1452


<210>  356
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  356
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggattggt gcaggctggg      300

ggctctctga gactctcctg tgcagcctct ggacgcacgt actatctcaa tgccatgggc      360

tggttccgcc agggtccagg gaaggaccgt gagtttgtag cagctataga ctggagtgat      420

ggtaacaaag actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc      480

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      540

tgtgcagccg acacaccacc ctgggggcct atgatctaca tcgaatcgta tgactcctgg      600

ggccagggga ccctggtcac ggtctcctcc ggaggcggtg ggtcaggtgg cggaggcagc      660

ggtggaggag gtagtggcgg tggcggtagt gggggtggag gcagcggagg cggaggcagt      720

gggggcggtg gatccgaggt gcagttggtg gagtctgggg gaggcttggt gcaacctggg      780

gggtctctga gactctcctg cgcagcctct ggaagcatcg gcggtctcaa tgccatggcc      840

tggtaccgcc aggctccagg aaaagagcgc gagttggtcg caggtatttt tggcgttggt      900

agcacgaggt acgcggactc cgtgaagggc cgattcacca tctctagaga catcgccaag      960

aacacggtgt ttctgcaaat gaacagcctg aattctgagg acacggccgt ttattactgt     1020

cggatgtcaa gtgttactcg tggtagttct gactactggg gtcaggggac cctggtcacg     1080

gtctcgagcg gagggggagg tagtgggggt ggctcagagg tacaactagt ggagtctggg     1140

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc     1200

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt     1260

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc     1320

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct     1380

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggt     1440

accctggtca ccgtctcctc a                                               1461


<210>  357
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  357
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gaggcttggt gcaacctggg      300

gggtctctga gactctcctg cgcagcctct ggaagcatcg gcggtctcaa tgccatggcc      360

tggtaccgcc aggctccagg aaaagagcgc gagttggtcg caggtatttt tggcgttggt      420

agcacgaggt acgcggactc cgtgaagggc cgattcacca tctctagaga catcgccaag      480

aacacggtgt ttctgcaaat gaacagcctg aattctgagg acacggccgt ttattactgt      540

cggatgtcaa gtgttactcg tggtagttct gactactggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg aggattggtg caggctgggg gctctctgag actctcctgt      780

gcagcctctg gacgcacgta ctatctcaat gccatgggct ggttccgcca gggtccaggg      840

aaggaccgtg agtttgtagc agctatagac tggagtgatg gtaacaaaga ctatgcagac      900

tccgtgaagg gccgattcac catctccaga gacaacgcca agaacacggt gtatctgcaa      960

atgaacagcc tgaaacctga ggacacggcc gtttattact gtgcagccga cacaccaccc     1020

tgggggccta tgatctacat cgaatcgtat gactcctggg gccaggggac cctggtcacg     1080

gtctcgagcg gagggggagg tagtgggggt ggctcagagg tacaactagt ggagtctggg     1140

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc     1200

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt     1260

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc     1320

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct     1380

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggt     1440

accctggtca ccgtctcctc a                                               1461


<210>  358
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  358
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgggtg gtgtgcctga aaagcgagtc ataatgtacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  359
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  359
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgttgg gtgtgcctga aaagcgagtc ataatgtacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  360
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  360
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgattg gtgtgcctga aaagcgagtc ataatgtacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  361
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  361
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcggttg gtgtgcctga aaagcgagtc ataatgtacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  362
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  362
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgatgg gtgtgcctga aaagcgagtc atactgtacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  363
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  363
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgatgg gtgtgcctga aaagcgagtc atagattacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  364
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  364
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgatgg gtgtgcctga aaagcgagtc atagagtacg gccaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  365
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  365
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggcctggttc agccgggtgg tagcctgcgt      120

ctgtcttgcg cggctagcgg tagcattggc ggcctgaacg cgatggcatg gtaccgccaa      180

gcaccgggta aagagcgcga attggttgcc ggcatctttg gcgtcggtag cacccgttac      240

gcggacagcg tcaaaggtcg tttcaccatt tcgcgcgata tctccaagaa taccgttttc      300

ctgcaaatga acagcctgcg tagcgaggac acggcggtgt actattgtcg tatgagctcc      360

gtgacgcgtg gtagcagcga ttattggggc caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  366
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  366
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccgtgttt      300

ctgcagatga atagcctgcg tagcgaagat accgcagttt attattgtcg tatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  367
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  367
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata ttagcaaaaa taccgtgtat      300

ctgcagatga atagcctgcg tagcgaagat accgcagttt attattgtcg tatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  368
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  368
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggcctggttc aaccgggtgg tagcctgcgc      120

ctgtcctgcg cagcttcggg tagcattggt ggcttgaatg ccatggcgtg gtaccgtcag      180

gcaccgggta aagagcgtga actggtggcc ggcatcttcg gcgttggtag cacgcgctat      240

gcggactccg tgaagggccg tttcaccatt agccgtgaca tcagcaaaaa caccgttttt      300

ctgcagatga acagcctgcg tagcgaggat acggcggtct actactgtgc gatgagctct      360

gtcacccgcg gtagcagcga ttattggggc caagggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  369
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  369
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccgtgtat      300

ctgcagatga atagcctgcg tagcgaagat accgcagttt attattgtcg tatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  370
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  370
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccgtgttt      300

ctgcagatga atagcctgcg tagcgaagat accgcagttt attattgtgc aatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  371
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  371
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata ttagcaaaaa taccgtgtat      300

ctgcagatga atagcctgcg tagcgaagat accgcagttt attattgtgc aatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  372
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  372
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggcctggttc aaccgggtgg tagcctgcgc      120

ctgagctgcg cagcgagcgg tagcattggc ggcctgaacg cgatggcctg gtatcgccag      180

gcaccgggca aagagcgtga attggttgcc ggcatctttg gtgtgggcag cacccgttac      240

gctgactctg tcaaaggtcg cttcacgatc agccgtgata acagcaagaa taccgtgtac      300

ctgcaaatga attcgctgcg tagcgaggac acggcggttt actattgtgc gatgtccagc      360

gtcacccgtg gttccagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  373
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  373
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata ttagcaaaaa taccgtgttt      300

ctgcagatga atagcctgcg tccagaagat accgcagttt attattgtcg tatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  374
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  374
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata ttagcaaaaa taccgtgttt      300

ctgcagatga atagcctgcg tgcggaagat accgcagttt attattgtcg tatgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  375
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  375
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagttatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg actcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  376
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  376
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgaggg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg actcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  377
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  377
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgc gaacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg actcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  378
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  378
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggccttt tatctacatc gaatcgtatg actcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  379
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  379
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctta tatctacatc gaatcgtatg actcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  380
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  380
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctct tatctacatc gaatcgtatg actcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  381
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  381
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatc agtcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  382
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  382
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg agtcctgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  383
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  383
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg acgattgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  384
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  384
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg acgagtgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  385
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  385
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg acacgtgggg ccaggggacc      420

ctggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  386
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  386
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgaca atagcaaaaa caccgtttat      300

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtcg catgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  387
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  387
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgaca atagcaaaaa caccgtttat      300

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtcg catgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  388
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  388
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgacgtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgaca atagcaaaaa caccgtttat      300

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtcg catgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  389
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  389
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgacgtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattggt ggtctgaatg caatggcatg gtatcgtcag      180

gcaccgggta aagaacgtga actggttgca ggtatttttg gtgttggtag cacccgttat      240

gcagatagcg ttaaaggtcg ttttaccatt agccgtgaca atagcaaaaa caccgtttat      300

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtcg catgagcagc      360

gttacccgtg gtagcagcga ttattggggt caggggaccc tggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  390
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  390
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattttt cgtattaatg caatggcatg gtatcgtcag      180

gcaccgggta aacagcgtga actggttgca gaaattaccg caggcggtag caccaattat      240

gcagatagcg ttaaaggtcg ctttaccatt agccgtgata atagctggaa taccctgtat      300

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgcaa cctggatcat      360

tataccacct gggatcgtcg tagcgcatat tggggtcagg ggaccctggt caccgtctcc      420

tcagcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgcacatcat      480

catcatcatc at                                                          492


<210>  391
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  391
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattttt cgtattaatg caatggcatg gtatcgtcag      180

gcaccgggta aacagcgtga actggttgca gaaattaccg caggcggtag caccaattat      240

gcagatagcg ttaaaggtcg ctttaccatt agccgtgata atagctggaa taccctgtat      300

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgcaa cctggatcat      360

tataccacct gggatcgtcg tagcgcatat tggggtcagg ggaccctggt caccgtctcc      420

tcagcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgcacatcat      480

catcatcatc at                                                          492


<210>  392
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  392
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg caccctgttt aaaattaatg caatgggttg gtatcgccag      180

gcaccgggta aacagcgtga actggttgca ctgattacca gcagcgatac caccgattat      240

gcagaagatg ttaaaggtcg ctttaccatt agccgtgata atagctggaa taccgtttat      300

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtca cagcgatcat      360

tatagcctgg gtgtgccgga aaaacgtgtt attctgtatg gtcaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  393
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  393
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgacgtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattttt cgtattaatg caatggcatg gtatcgtcag      180

gcaccgggta aacagcgtga actggttgca gaaattaccg caggcggtag caccaattat      240

gcagatagcg ttaaaggtcg ctttaccatt agccgtgata atagctggaa taccctgtat      300

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgcaa cctggatcat      360

tataccacct gggatcgtcg tagcgcatat tggggtcagg ggaccctggt caccgtctcc      420

tcagcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgcacatcat      480

catcatcatc at                                                          492


<210>  394
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  394
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgacgtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg tagcattttt cgtattaatg caatggcatg gtatcgtcag      180

gcaccgggta aacagcgtga actggttgca gaaattaccg caggcggtag caccaattat      240

gcagatagcg ttaaaggtcg ctttaccatt agccgtgata atagctggaa taccctgtat      300

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgcaa cctggatcat      360

tataccacct gggatcgtcg tagcgcatat tggggtcagg ggaccctggt caccgtctcc      420

tcagcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgcacatcat      480

catcatcatc at                                                          492


<210>  395
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  395
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtcctga atgggttagc accgttagtc cgggtggaat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg ataatagcaa aaataccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tctgcgtgat      360

ctgggtaatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  396
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  396
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtccggc atgggttagc accgttagtc cgggtggtat tacaaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg ataatagcaa aaataccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tctgcgtgat      360

ctgggtaatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  397
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  397
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtcctga atgggttagc accgttagtc cgggtggaat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg ataatagcaa aaataccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tctgcgtgat      360

ctgagcaatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  398
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  398
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg ttctctgcgt      120

ctgagctgtg cagcaagcgg ttttaccttt agcagctatc cgatgagctg ggttcgtcag      180

gcaccgggta aaggtccggc atgggttagc accgttagtc cgggtggaat taccaccagt      240

tatgcagata gcgttaaagg tcgttttacc attagccgtg ataatagcaa aaataccctg      300

tatctgcaga tgaatagcct gcgtcctgaa gataccgcag tttattattg tctgcgtgat      360

ctgagcaatc gtggtcaggg gaccctggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  399
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  399
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc      720

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt      780

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc      840

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct      900

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggg      960

accctggtca cggtctcctc aggaggtggc gggtccggag gaggtagtga ggtgcagctg     1020

gtggagtctg ggggtggtct ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca     1080

agcggtcgta cctattatct gaatgcaatg ggttggtttc gtcaggcacc gggtaaagaa     1140

cgtgaatttg ttgcagccat tgattggagc gaaggcaata aagattatgc cgatagcgtg     1200

aaaggtcgtt ttaccattag ccgtgataac agcaaaaaca ccgtttatct gcagatgaat     1260

agcctgcgtc ctgaagatac cgcagtttat tattgtgcag cagatacccc tccgtggggt     1320

ccgctgattt atattgaaag ctatgatagc tggggtcagg ggaccctggt caccgtctcc     1380

tca                                                                   1383


<210>  400
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  400
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg tggcttggtg caaccgggta acagtctgcg ccttagctgc      780

gcagcgtctg gctttacctt cagctccttt ggcatgagct gggttcgcca ggctccggga      840

aaaggactgg aatgggtttc gtctattagc ggcagtggta gcgatacgct ctacgcggac      900

tccgtgaagg gccgtttcac catctcccgc gataacgcca aaactacact gtatctgcaa      960

atgaatagcc tgcgtcctga agacacggcc gtttattact gtactattgg tggctcgtta     1020

agccgttctt cacaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggtctggtt     1200

cagcctggtg gtagcctgcg tctgagctgt gcagcaagcg gtcgtaccta ttatctgaat     1260

gcaatgggtt ggtttcgtca ggcaccgggt aaagaacgtg aatttgttgc agccattgat     1320

tggagcgaag gcaataaaga ttatgccgat agcgtgaaag gtcgttttac cattagccgt     1380

gataacagca aaaacaccgt ttatctgcag atgaatagcc tgcgtcctga agataccgca     1440

gtttattatt gtgcagcaga tacccctccg tggggtccgc tgatttatat tgaaagctat     1500

gatagctggg gtcaggggac cctggtcacc gtctcctca                            1539


<210>  401
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  401
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggtcgtacc      720

tattatctga atgcaatggg ttggtttcgt caggcaccgg gtaaagaacg tgaatttgtt      780

gcagccattg attggagcga aggcaataaa gattatgccg atagcgtgaa aggtcgtttt      840

accattagcc gtgataacag caaaaacacc gtttatctgc agatgaatag cctgcgtcct      900

gaagataccg cagtttatta ttgtgcagca gatacccctc cgtggggtcc gctgatttat      960

attgaaagct atgatagctg gggtcagggg accctggtca cggtctcctc aggaggtggc     1020

gggtccggag gaggtagtga ggtgcagctg gtggagtctg ggggtggctt ggtgcaaccg     1080

ggtaacagtc tgcgccttag ctgcgcagcg tctggcttta ccttcagctc ctttggcatg     1140

agctgggttc gccaggctcc gggaaaagga ctggaatggg tttcgtctat tagcggcagt     1200

ggtagcgata cgctctacgc ggactccgtg aagggccgtt tcaccatctc ccgcgataac     1260

gccaaaacta cactgtatct gcaaatgaat agcctgcgtc ctgaagacac ggccgtttat     1320

tactgtacta ttggtggctc gttaagccgt tcttcacagg ggaccctggt caccgtctcc     1380

tca                                                                   1383


<210>  402
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  402
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg tggtctggtt cagcctggtg gtagcctgcg tctgagctgt      780

gcagcaagcg gtcgtaccta ttatctgaat gcaatgggtt ggtttcgtca ggcaccgggt      840

aaagaacgtg aatttgttgc agccattgat tggagcgaag gcaataaaga ttatgccgat      900

agcgtgaaag gtcgttttac cattagccgt gataacagca aaaacaccgt ttatctgcag      960

atgaatagcc tgcgtcctga agataccgca gtttattatt gtgcagcaga tacccctccg     1020

tggggtccgc tgatttatat tgaaagctat gatagctggg gtcaggggac cctggtcacg     1080

gtctcgagcg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt     1140

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg ctcagaggta     1200

caactagtgg agtctggggg tggcttggtg caaccgggta acagtctgcg ccttagctgc     1260

gcagcgtctg gctttacctt cagctccttt ggcatgagct gggttcgcca ggctccggga     1320

aaaggactgg aatgggtttc gtctattagc ggcagtggta gcgatacgct ctacgcggac     1380

tccgtgaagg gccgtttcac catctcccgc gataacgcca aaactacact gtatctgcaa     1440

atgaatagcc tgcgtcctga agacacggcc gtttattact gtactattgg tggctcgtta     1500

agccgttctt cacaggggac cctggtcacc gtctcctca                            1539


<210>  403
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  403
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc      720

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt      780

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc      840

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct      900

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggg      960

accctggtca cggtctcctc aggaggtggc gggtccggag gaggtagtga ggtgcagctg     1020

gtggagtctg ggggtggtct ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca     1080

agcggtagca tttttcgtat taatgcaatg gcatggtatc gtcaggcacc gggtaaacag     1140

cgtgaactgg ttgcagaaat taccgcaggc ggtagcacca attatgcaga tagcgttaaa     1200

ggtcgcttta ccattagccg tgataatagc tggaataccc tgtatctgca gatgaatagc     1260

ctgcgtcctg aagataccgc agtttattat tgcaacctgg atcattatac cacctgggat     1320

cgtcgtagcg catattgggg tcaggggacc ctggtcaccg tctcctca                  1368


<210>  404
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  404
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg tggcttggtg caaccgggta acagtctgcg ccttagctgc      780

gcagcgtctg gctttacctt cagctccttt ggcatgagct gggttcgcca ggctccggga      840

aaaggactgg aatgggtttc gtctattagc ggcagtggta gcgatacgct ctacgcggac      900

tccgtgaagg gccgtttcac catctcccgc gataacgcca aaactacact gtatctgcaa      960

atgaatagcc tgcgtcctga agacacggcc gtttattact gtactattgg tggctcgtta     1020

agccgttctt cacaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggtctggtt     1200

cagcctggtg gtagcctgcg tctgagctgt gcagcaagcg gtagcatttt tcgtattaat     1260

gcaatggcat ggtatcgtca ggcaccgggt aaacagcgtg aactggttgc agaaattacc     1320

gcaggcggta gcaccaatta tgcagatagc gttaaaggtc gctttaccat tagccgtgat     1380

aatagctgga ataccctgta tctgcagatg aatagcctgc gtcctgaaga taccgcagtt     1440

tattattgca acctggatca ttataccacc tgggatcgtc gtagcgcata ttggggtcag     1500

gggaccctgg tcaccgtctc ctca                                            1524


<210>  405
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  405
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggtagcatt      720

tttcgtatta atgcaatggc atggtatcgt caggcaccgg gtaaacagcg tgaactggtt      780

gcagaaatta ccgcaggcgg tagcaccaat tatgcagata gcgttaaagg tcgctttacc      840

attagccgtg ataatagctg gaataccctg tatctgcaga tgaatagcct gcgtcctgaa      900

gataccgcag tttattattg caacctggat cattatacca cctgggatcg tcgtagcgca      960

tattggggtc aggggaccct ggtcacggtc tcctcaggag gtggcgggtc cggaggaggt     1020

agtgaggtgc agctggtgga gtctgggggt ggcttggtgc aaccgggtaa cagtctgcgc     1080

cttagctgcg cagcgtctgg ctttaccttc agctcctttg gcatgagctg ggttcgccag     1140

gctccgggaa aaggactgga atgggtttcg tctattagcg gcagtggtag cgatacgctc     1200

tacgcggact ccgtgaaggg ccgtttcacc atctcccgcg ataacgccaa aactacactg     1260

tatctgcaaa tgaatagcct gcgtcctgaa gacacggccg tttattactg tactattggt     1320

ggctcgttaa gccgttcttc acaggggacc ctggtcaccg tctcctca                  1368


<210>  406
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  406
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg tggtctggtt cagcctggtg gtagcctgcg tctgagctgt      780

gcagcaagcg gtagcatttt tcgtattaat gcaatggcat ggtatcgtca ggcaccgggt      840

aaacagcgtg aactggttgc agaaattacc gcaggcggta gcaccaatta tgcagatagc      900

gttaaaggtc gctttaccat tagccgtgat aatagctgga ataccctgta tctgcagatg      960

aatagcctgc gtcctgaaga taccgcagtt tattattgca acctggatca ttataccacc     1020

tgggatcgtc gtagcgcata ttggggtcag gggaccctgg tcacggtctc gagcggaggc     1080

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt     1140

ggaggcagcg gaggcggagg cagtgggggc ggtggctcag aggtacaact agtggagtct     1200

gggggtggct tggtgcaacc gggtaacagt ctgcgcctta gctgcgcagc gtctggcttt     1260

accttcagct cctttggcat gagctgggtt cgccaggctc cgggaaaagg actggaatgg     1320

gtttcgtcta ttagcggcag tggtagcgat acgctctacg cggactccgt gaagggccgt     1380

ttcaccatct cccgcgataa cgccaaaact acactgtatc tgcaaatgaa tagcctgcgt     1440

cctgaagaca cggccgttta ttactgtact attggtggct cgttaagccg ttcttcacag     1500

gggaccctgg tcaccgtctc ctca                                            1524


<210>  407
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  407
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc      720

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt      780

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc      840

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct      900

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggg      960

accctggtca cggtctcctc aggaggtggc gggtccggag gaggtagtga ggtgcagctg     1020

gtggagtctg ggggtggtct ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca     1080

agcggcaccc tgtttaaaat taatgcaatg ggttggtatc gccaggcacc gggtaaacgt     1140

cgtgaactgg ttgcactgat taccagcagc gataccaccg attatgcaga agatgttaaa     1200

ggtcgcttta ccattagccg tgataatagc tggaataccg tttatctgca gatgaatagc     1260

ctgcgtcctg aagataccgc agtttattat tgtcacagcg atcattatag cctgggtgtg     1320

ccggaaaaac gtgttattct gtatggtcag gggaccctgg tcaccgtctc ctca           1374


<210>  408
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  408
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg tggcttggtg caaccgggta acagtctgcg ccttagctgc      780

gcagcgtctg gctttacctt cagctccttt ggcatgagct gggttcgcca ggctccggga      840

aaaggactgg aatgggtttc gtctattagc ggcagtggta gcgatacgct ctacgcggac      900

tccgtgaagg gccgtttcac catctcccgc gataacgcca aaactacact gtatctgcaa      960

atgaatagcc tgcgtcctga agacacggcc gtttattact gtactattgg tggctcgtta     1020

agccgttctt cacaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggtctggtt     1200

cagcctggtg gtagcctgcg tctgagctgt gcagcaagcg gcaccctgtt taaaattaat     1260

gcaatgggtt ggtatcgcca ggcaccgggt aaacgtcgtg aactggttgc actgattacc     1320

agcagcgata ccaccgatta tgcagaagat gttaaaggtc gctttaccat tagccgtgat     1380

aatagctgga ataccgttta tctgcagatg aatagcctgc gtcctgaaga taccgcagtt     1440

tattattgtc acagcgatca ttatagcctg ggtgtgccgg aaaaacgtgt tattctgtat     1500

ggtcagggga ccctggtcac cgtctcctca                                      1530


<210>  409
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  409
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggcaccctg      720

tttaaaatta atgcaatggg ttggtatcgc caggcaccgg gtaaacgtcg tgaactggtt      780

gcactgatta ccagcagcga taccaccgat tatgcagaag atgttaaagg tcgctttacc      840

attagccgtg ataatagctg gaataccgtt tatctgcaga tgaatagcct gcgtcctgaa      900

gataccgcag tttattattg tcacagcgat cattatagcc tgggtgtgcc ggaaaaacgt      960

gttattctgt atggtcaggg gaccctggtc acggtctcct caggaggtgg cgggtccgga     1020

ggaggtagtg aggtgcagct ggtggagtct gggggtggct tggtgcaacc gggtaacagt     1080

ctgcgcctta gctgcgcagc gtctggcttt accttcagct cctttggcat gagctgggtt     1140

cgccaggctc cgggaaaagg actggaatgg gtttcgtcta ttagcggcag tggtagcgat     1200

acgctctacg cggactccgt gaagggccgt ttcaccatct cccgcgataa cgccaaaact     1260

acactgtatc tgcaaatgaa tagcctgcgt cctgaagaca cggccgttta ttactgtact     1320

attggtggct cgttaagccg ttcttcacag gggaccctgg tcaccgtctc ctca           1374


<210>  410
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  410
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctccg gaggcggtgg gtcaggtggc ggaggcagcg gtggaggagg tagtggcggt      660

ggcggtagtg ggggtggagg cagcggaggc ggaggcagtg ggggcggtgg atccgaggtg      720

cagttggtgg agtctggggg tggtctggtt cagcctggtg gtagcctgcg tctgagctgt      780

gcagcaagcg gcaccctgtt taaaattaat gcaatgggtt ggtatcgcca ggcaccgggt      840

aaacgtcgtg aactggttgc actgattacc agcagcgata ccaccgatta tgcagaagat      900

gttaaaggtc gctttaccat tagccgtgat aatagctgga ataccgttta tctgcagatg      960

aatagcctgc gtcctgaaga taccgcagtt tattattgtc acagcgatca ttatagcctg     1020

ggtgtgccgg aaaaacgtgt tattctgtat ggtcagggga ccctggtcac ggtctcgagc     1080

ggaggcggtg ggtcaggtgg cggaggcagc ggtggaggag gtagtggcgg tggcggtagt     1140

gggggtggag gcagcggagg cggaggcagt gggggcggtg gctcagaggt acaactagtg     1200

gagtctgggg gtggcttggt gcaaccgggt aacagtctgc gccttagctg cgcagcgtct     1260

ggctttacct tcagctcctt tggcatgagc tgggttcgcc aggctccggg aaaaggactg     1320

gaatgggttt cgtctattag cggcagtggt agcgatacgc tctacgcgga ctccgtgaag     1380

ggccgtttca ccatctcccg cgataacgcc aaaactacac tgtatctgca aatgaatagc     1440

ctgcgtcctg aagacacggc cgtttattac tgtactattg gtggctcgtt aagccgttct     1500

tcacagggga ccctggtcac cgtctcctca                                      1530


<210>  411
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  411
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtcct gaatgggtta gcaccgttag tccgggtgga      420

attaccacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggct tggtgcaacc gggtaacagt ctgcgcctta gctgcgcagc gtctggcttt      780

accttcagct cctttggcat gagctgggtt cgccaggctc cgggaaaagg actggaatgg      840

gtttcgtcta ttagcggcag tggtagcgat acgctctacg cggactccgt gaagggccgt      900

ttcaccatct cccgcgataa cgccaaaact acactgtatc tgcaaatgaa tagcctgcgt      960

cctgaagaca cggccgttta ttactgtact attggtggct cgttaagccg ttcttcacag     1020

gggaccctgg tcacggtctc gagcggaggc ggtgggtcag gtggcggagg cagcggtgga     1080

ggaggtagtg gcggtggcgg tagtgggggt ggaggcagcg gaggcggagg cagtgggggc     1140

ggtggctcag aggtacaact agtggagtct gggggtggtc tggttcagcc tggtggtagc     1200

ctgcgtctga gctgtgcagc aagcggtagc atttttcgta ttaatgcaat ggcatggtat     1260

cgtcaggcac cgggtaaaca gcgtgaactg gttgcagaaa ttaccgcagg cggtagcacc     1320

aattatgcag atagcgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1380

ctgtatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgcaacctg     1440

gatcattata ccacctggga tcgtcgtagc gcatattggg gtcaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  412
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  412
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtccg gcatgggtta gcaccgttag tccgggtggt      420

attacaacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggct tggtgcaacc gggtaacagt ctgcgcctta gctgcgcagc gtctggcttt      780

accttcagct cctttggcat gagctgggtt cgccaggctc cgggaaaagg actggaatgg      840

gtttcgtcta ttagcggcag tggtagcgat acgctctacg cggactccgt gaagggccgt      900

ttcaccatct cccgcgataa cgccaaaact acactgtatc tgcaaatgaa tagcctgcgt      960

cctgaagaca cggccgttta ttactgtact attggtggct cgttaagccg ttcttcacag     1020

gggaccctgg tcacggtctc gagcggaggc ggtgggtcag gtggcggagg cagcggtgga     1080

ggaggtagtg gcggtggcgg tagtgggggt ggaggcagcg gaggcggagg cagtgggggc     1140

ggtggctcag aggtacaact agtggagtct gggggtggtc tggttcagcc tggtggtagc     1200

ctgcgtctga gctgtgcagc aagcggtagc atttttcgta ttaatgcaat ggcatggtat     1260

cgtcaggcac cgggtaaaca gcgtgaactg gttgcagaaa ttaccgcagg cggtagcacc     1320

aattatgcag atagcgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1380

ctgtatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgcaacctg     1440

gatcattata ccacctggga tcgtcgtagc gcatattggg gtcaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  413
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  413
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtcct gaatgggtta gcaccgttag tccgggtgga      420

attaccacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggtc tggttcagcc tggtggtagc ctgcgtctga gctgtgcagc aagcggtagc      780

atttttcgta ttaatgcaat ggcatggtat cgtcaggcac cgggtaaaca gcgtgaactg      840

gttgcagaaa ttaccgcagg cggtagcacc aattatgcag atagcgttaa aggtcgcttt      900

accattagcc gtgataatag ctggaatacc ctgtatctgc agatgaatag cctgcgtcct      960

gaagataccg cagtttatta ttgcaacctg gatcattata ccacctggga tcgtcgtagc     1020

gcatattggg gtcaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggcttggtg     1200

caaccgggta acagtctgcg ccttagctgc gcagcgtctg gctttacctt cagctccttt     1260

ggcatgagct gggttcgcca ggctccggga aaaggactgg aatgggtttc gtctattagc     1320

ggcagtggta gcgatacgct ctacgcggac tccgtgaagg gccgtttcac catctcccgc     1380

gataacgcca aaactacact gtatctgcaa atgaatagcc tgcgtcctga agacacggcc     1440

gtttattact gtactattgg tggctcgtta agccgttctt cacaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  414
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  414
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtccg gcatgggtta gcaccgttag tccgggtggt      420

attacaacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggtc tggttcagcc tggtggtagc ctgcgtctga gctgtgcagc aagcggtagc      780

atttttcgta ttaatgcaat ggcatggtat cgtcaggcac cgggtaaaca gcgtgaactg      840

gttgcagaaa ttaccgcagg cggtagcacc aattatgcag atagcgttaa aggtcgcttt      900

accattagcc gtgataatag ctggaatacc ctgtatctgc agatgaatag cctgcgtcct      960

gaagataccg cagtttatta ttgcaacctg gatcattata ccacctggga tcgtcgtagc     1020

gcatattggg gtcaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggcttggtg     1200

caaccgggta acagtctgcg ccttagctgc gcagcgtctg gctttacctt cagctccttt     1260

ggcatgagct gggttcgcca ggctccggga aaaggactgg aatgggtttc gtctattagc     1320

ggcagtggta gcgatacgct ctacgcggac tccgtgaagg gccgtttcac catctcccgc     1380

gataacgcca aaactacact gtatctgcaa atgaatagcc tgcgtcctga agacacggcc     1440

gtttattact gtactattgg tggctcgtta agccgttctt cacaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  415
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  415
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattt ttcgtattaa tgcaatggca      360

tggtatcgtc aggcaccggg taaacagcgt gaactggttg cagaaattac cgcaggcggt      420

agcaccaatt atgcagatag cgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccctgt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgc      540

aacctggatc attataccac ctgggatcgt cgtagcgcat attggggtca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggtggc ttggtgcaac cgggtaacag tctgcgcctt      780

agctgcgcag cgtctggctt taccttcagc tcctttggca tgagctgggt tcgccaggct      840

ccgggaaaag gactggaatg ggtttcgtct attagcggca gtggtagcga tacgctctac      900

gcggactccg tgaagggccg tttcaccatc tcccgcgata acgccaaaac tacactgtat      960

ctgcaaatga atagcctgcg tcctgaagac acggccgttt attactgtac tattggtggc     1020

tcgttaagcc gttcttcaca ggggaccctg gtcacggtct cgagcggagg cggtgggtca     1080

ggtggcggag gcagcggtgg aggaggtagt ggcggtggcg gtagtggggg tggaggcagc     1140

ggaggcggag gcagtggggg cggtggctca gaggtacaac tagtggagtc tgggggtggt     1200

ctggttcagc ctggtggtag cctgcgtctg agctgtgcag caagcggttt tacctttagc     1260

agctatccga tgagctgggt tcgtcaggca ccgggtaaag gtcctgaatg ggttagcacc     1320

gttagtccgg gtggaattac caccagttat gcagatagcg ttaaaggtcg ttttaccatt     1380

agccgtgata atagcaaaaa taccctgtat ctgcagatga atagcctgcg tcctgaagat     1440

accgcagttt attattgtct gcgtgatctg ggtaatcgtg gtcaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  416
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  416
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattt ttcgtattaa tgcaatggca      360

tggtatcgtc aggcaccggg taaacagcgt gaactggttg cagaaattac cgcaggcggt      420

agcaccaatt atgcagatag cgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccctgt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgc      540

aacctggatc attataccac ctgggatcgt cgtagcgcat attggggtca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggtggc ttggtgcaac cgggtaacag tctgcgcctt      780

agctgcgcag cgtctggctt taccttcagc tcctttggca tgagctgggt tcgccaggct      840

ccgggaaaag gactggaatg ggtttcgtct attagcggca gtggtagcga tacgctctac      900

gcggactccg tgaagggccg tttcaccatc tcccgcgata acgccaaaac tacactgtat      960

ctgcaaatga atagcctgcg tcctgaagac acggccgttt attactgtac tattggtggc     1020

tcgttaagcc gttcttcaca ggggaccctg gtcacggtct cgagcggagg cggtgggtca     1080

ggtggcggag gcagcggtgg aggaggtagt ggcggtggcg gtagtggggg tggaggcagc     1140

ggaggcggag gcagtggggg cggtggctca gaggtacaac tagtggagtc tgggggtggt     1200

ctggttcagc ctggtggtag cctgcgtctg agctgtgcag caagcggttt tacctttagc     1260

agctatccga tgagctgggt tcgtcaggca ccgggtaaag gtccggcatg ggttagcacc     1320

gttagtccgg gtggtattac aaccagttat gcagatagcg ttaaaggtcg ttttaccatt     1380

agccgtgata atagcaaaaa taccctgtat ctgcagatga atagcctgcg tcctgaagat     1440

accgcagttt attattgtct gcgtgatctg ggtaatcgtg gtcaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  417
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  417
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattt ttcgtattaa tgcaatggca      360

tggtatcgtc aggcaccggg taaacagcgt gaactggttg cagaaattac cgcaggcggt      420

agcaccaatt atgcagatag cgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccctgt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgc      540

aacctggatc attataccac ctgggatcgt cgtagcgcat attggggtca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggtggt ctggttcagc ctggtggtag cctgcgtctg      780

agctgtgcag caagcggttt tacctttagc agctatccga tgagctgggt tcgtcaggca      840

ccgggtaaag gtcctgaatg ggttagcacc gttagtccgg gtggaattac caccagttat      900

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      960

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtct gcgtgatctg     1020

ggtaatcgtg gtcaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggcttggtg     1200

caaccgggta acagtctgcg ccttagctgc gcagcgtctg gctttacctt cagctccttt     1260

ggcatgagct gggttcgcca ggctccggga aaaggactgg aatgggtttc gtctattagc     1320

ggcagtggta gcgatacgct ctacgcggac tccgtgaagg gccgtttcac catctcccgc     1380

gataacgcca aaactacact gtatctgcaa atgaatagcc tgcgtcctga agacacggcc     1440

gtttattact gtactattgg tggctcgtta agccgttctt cacaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  418
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  418
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattt ttcgtattaa tgcaatggca      360

tggtatcgtc aggcaccggg taaacagcgt gaactggttg cagaaattac cgcaggcggt      420

agcaccaatt atgcagatag cgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccctgt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgc      540

aacctggatc attataccac ctgggatcgt cgtagcgcat attggggtca ggggaccctg      600

gtcacggtct cctccggagg cggtgggtca ggtggcggag gcagcggtgg aggaggtagt      660

ggcggtggcg gtagtggggg tggaggcagc ggaggcggag gcagtggggg cggtggatcc      720

gaggtgcagt tggtggagtc tgggggtggt ctggttcagc ctggtggtag cctgcgtctg      780

agctgtgcag caagcggttt tacctttagc agctatccga tgagctgggt tcgtcaggca      840

ccgggtaaag gtccggcatg ggttagcacc gttagtccgg gtggtattac aaccagttat      900

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      960

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtct gcgtgatctg     1020

ggtaatcgtg gtcaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc     1080

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc     1140

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggggg tggcttggtg     1200

caaccgggta acagtctgcg ccttagctgc gcagcgtctg gctttacctt cagctccttt     1260

ggcatgagct gggttcgcca ggctccggga aaaggactgg aatgggtttc gtctattagc     1320

ggcagtggta gcgatacgct ctacgcggac tccgtgaagg gccgtttcac catctcccgc     1380

gataacgcca aaactacact gtatctgcaa atgaatagcc tgcgtcctga agacacggcc     1440

gtttattact gtactattgg tggctcgtta agccgttctt cacaggggac cctggtcacc     1500

gtctcctca                                                             1509


<210>  419
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  419
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtcct gaatgggtta gcaccgttag tccgggtgga      420

attaccacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggct tggtgcaacc gggtaacagt ctgcgcctta gctgcgcagc gtctggcttt      780

accttcagct cctttggcat gagctgggtt cgccaggctc cgggaaaagg actggaatgg      840

gtttcgtcta ttagcggcag tggtagcgat acgctctacg cggactccgt gaagggccgt      900

ttcaccatct cccgcgataa cgccaaaact acactgtatc tgcaaatgaa tagcctgcgt      960

cctgaagaca cggccgttta ttactgtact attggtggct cgttaagccg ttcttcacag     1020

gggaccctgg tcacggtctc gagcggaggc ggtgggtcag gtggcggagg cagcggtgga     1080

ggaggtagtg gcggtggcgg tagtgggggt ggaggcagcg gaggcggagg cagtgggggc     1140

ggtggctcag aggtacaact agtggagtct gggggtggtc tggttcagcc tggtggtagc     1200

ctgcgtctga gctgtgcagc aagcggcacc ctgtttaaaa ttaatgcaat gggttggtat     1260

cgccaggcac cgggtaaacg tcgtgaactg gttgcactga ttaccagcag cgataccacc     1320

gattatgcag aagatgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1380

gtttatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtcacagc     1440

gatcattata gcctgggtgt gccggaaaaa cgtgttattc tgtatggtca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  420
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  420
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtccg gcatgggtta gcaccgttag tccgggtggt      420

attacaacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggct tggtgcaacc gggtaacagt ctgcgcctta gctgcgcagc gtctggcttt      780

accttcagct cctttggcat gagctgggtt cgccaggctc cgggaaaagg actggaatgg      840

gtttcgtcta ttagcggcag tggtagcgat acgctctacg cggactccgt gaagggccgt      900

ttcaccatct cccgcgataa cgccaaaact acactgtatc tgcaaatgaa tagcctgcgt      960

cctgaagaca cggccgttta ttactgtact attggtggct cgttaagccg ttcttcacag     1020

gggaccctgg tcacggtctc gagcggaggc ggtgggtcag gtggcggagg cagcggtgga     1080

ggaggtagtg gcggtggcgg tagtgggggt ggaggcagcg gaggcggagg cagtgggggc     1140

ggtggctcag aggtacaact agtggagtct gggggtggtc tggttcagcc tggtggtagc     1200

ctgcgtctga gctgtgcagc aagcggcacc ctgtttaaaa ttaatgcaat gggttggtat     1260

cgccaggcac cgggtaaacg tcgtgaactg gttgcactga ttaccagcag cgataccacc     1320

gattatgcag aagatgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1380

gtttatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtcacagc     1440

gatcattata gcctgggtgt gccggaaaaa cgtgttattc tgtatggtca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  421
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  421
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtcct gaatgggtta gcaccgttag tccgggtgga      420

attaccacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggtc tggttcagcc tggtggtagc ctgcgtctga gctgtgcagc aagcggcacc      780

ctgtttaaaa ttaatgcaat gggttggtat cgccaggcac cgggtaaacg tcgtgaactg      840

gttgcactga ttaccagcag cgataccacc gattatgcag aagatgttaa aggtcgcttt      900

accattagcc gtgataatag ctggaatacc gtttatctgc agatgaatag cctgcgtcct      960

gaagataccg cagtttatta ttgtcacagc gatcattata gcctgggtgt gccggaaaaa     1020

cgtgttattc tgtatggtca ggggaccctg gtcacggtct cgagcggagg cggtgggtca     1080

ggtggcggag gcagcggtgg aggaggtagt ggcggtggcg gtagtggggg tggaggcagc     1140

ggaggcggag gcagtggggg cggtggctca gaggtacaac tagtggagtc tgggggtggc     1200

ttggtgcaac cgggtaacag tctgcgcctt agctgcgcag cgtctggctt taccttcagc     1260

tcctttggca tgagctgggt tcgccaggct ccgggaaaag gactggaatg ggtttcgtct     1320

attagcggca gtggtagcga tacgctctac gcggactccg tgaagggccg tttcaccatc     1380

tcccgcgata acgccaaaac tacactgtat ctgcaaatga atagcctgcg tcctgaagac     1440

acggccgttt attactgtac tattggtggc tcgttaagcc gttcttcaca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  422
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  422
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtccg gcatgggtta gcaccgttag tccgggtggt      420

attacaacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctccggaggc      600

ggtgggtcag gtggcggagg cagcggtgga ggaggtagtg gcggtggcgg tagtgggggt      660

ggaggcagcg gaggcggagg cagtgggggc ggtggatccg aggtgcagtt ggtggagtct      720

gggggtggtc tggttcagcc tggtggtagc ctgcgtctga gctgtgcagc aagcggcacc      780

ctgtttaaaa ttaatgcaat gggttggtat cgccaggcac cgggtaaacg tcgtgaactg      840

gttgcactga ttaccagcag cgataccacc gattatgcag aagatgttaa aggtcgcttt      900

accattagcc gtgataatag ctggaatacc gtttatctgc agatgaatag cctgcgtcct      960

gaagataccg cagtttatta ttgtcacagc gatcattata gcctgggtgt gccggaaaaa     1020

cgtgttattc tgtatggtca ggggaccctg gtcacggtct cgagcggagg cggtgggtca     1080

ggtggcggag gcagcggtgg aggaggtagt ggcggtggcg gtagtggggg tggaggcagc     1140

ggaggcggag gcagtggggg cggtggctca gaggtacaac tagtggagtc tgggggtggc     1200

ttggtgcaac cgggtaacag tctgcgcctt agctgcgcag cgtctggctt taccttcagc     1260

tcctttggca tgagctgggt tcgccaggct ccgggaaaag gactggaatg ggtttcgtct     1320

attagcggca gtggtagcga tacgctctac gcggactccg tgaagggccg tttcaccatc     1380

tcccgcgata acgccaaaac tacactgtat ctgcaaatga atagcctgcg tcctgaagac     1440

acggccgttt attactgtac tattggtggc tcgttaagcc gttcttcaca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  423
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  423
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggtggcttgg tgcaaccggg taacagtctg      780

cgccttagct gcgcagcgtc tggctttacc ttcagctcct ttggcatgag ctgggttcgc      840

caggctccgg gaaaaggact ggaatgggtt tcgtctatta gcggcagtgg tagcgatacg      900

ctctacgcgg actccgtgaa gggccgtttc accatctccc gcgataacgc caaaactaca      960

ctgtatctgc aaatgaatag cctgcgtcct gaagacacgg ccgtttatta ctgtactatt     1020

ggtggctcgt taagccgttc ttcacagggg accctggtca cggtctcgag cggaggcggt     1080

gggtcaggtg gcggaggcag cggtggagga ggtagtggcg gtggcggtag tgggggtgga     1140

ggcagcggag gcggaggcag tgggggcggt ggctcagagg tacaactagt ggagtctggg     1200

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggttttacc     1260

tttagcagct atccgatgag ctgggttcgt caggcaccgg gtaaaggtcc tgaatgggtt     1320

agcaccgtta gtccgggtgg aattaccacc agttatgcag atagcgttaa aggtcgtttt     1380

accattagcc gtgataatag caaaaatacc ctgtatctgc agatgaatag cctgcgtcct     1440

gaagataccg cagtttatta ttgtctgcgt gatctgggta atcgtggtca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  424
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  424
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga aaagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggtggcttgg tgcaaccggg taacagtctg      780

cgccttagct gcgcagcgtc tggctttacc ttcagctcct ttggcatgag ctgggttcgc      840

caggctccgg gaaaaggact ggaatgggtt tcgtctatta gcggcagtgg tagcgatacg      900

ctctacgcgg actccgtgaa gggccgtttc accatctccc gcgataacgc caaaactaca      960

ctgtatctgc aaatgaatag cctgcgtcct gaagacacgg ccgtttatta ctgtactatt     1020

ggtggctcgt taagccgttc ttcacagggg accctggtca cggtctcgag cggaggcggt     1080

gggtcaggtg gcggaggcag cggtggagga ggtagtggcg gtggcggtag tgggggtgga     1140

ggcagcggag gcggaggcag tgggggcggt ggctcagagg tacaactagt ggagtctggg     1200

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggttttacc     1260

tttagcagct atccgatgag ctgggttcgt caggcaccgg gtaaaggtcc ggcatgggtt     1320

agcaccgtta gtccgggtgg tattacaacc agttatgcag atagcgttaa aggtcgtttt     1380

accattagcc gtgataatag caaaaatacc ctgtatctgc agatgaatag cctgcgtcct     1440

gaagataccg cagtttatta ttgtctgcgt gatctgggta atcgtggtca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  425
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  425
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggtggtctgg ttcagcctgg tggtagcctg      780

cgtctgagct gtgcagcaag cggttttacc tttagcagct atccgatgag ctgggttcgt      840

caggcaccgg gtaaaggtcc tgaatgggtt agcaccgtta gtccgggtgg aattaccacc      900

agttatgcag atagcgttaa aggtcgtttt accattagcc gtgataatag caaaaatacc      960

ctgtatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtctgcgt     1020

gatctgggta atcgtggtca ggggaccctg gtcacggtct cgagcggagg cggtgggtca     1080

ggtggcggag gcagcggtgg aggaggtagt ggcggtggcg gtagtggggg tggaggcagc     1140

ggaggcggag gcagtggggg cggtggctca gaggtacaac tagtggagtc tgggggtggc     1200

ttggtgcaac cgggtaacag tctgcgcctt agctgcgcag cgtctggctt taccttcagc     1260

tcctttggca tgagctgggt tcgccaggct ccgggaaaag gactggaatg ggtttcgtct     1320

attagcggca gtggtagcga tacgctctac gcggactccg tgaagggccg tttcaccatc     1380

tcccgcgata acgccaaaac tacactgtat ctgcaaatga atagcctgcg tcctgaagac     1440

acggccgttt attactgtac tattggtggc tcgttaagcc gttcttcaca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  426
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  426
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc cggaggcggt gggtcaggtg gcggaggcag cggtggagga      660

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt      720

ggatccgagg tgcagttggt ggagtctggg ggtggtctgg ttcagcctgg tggtagcctg      780

cgtctgagct gtgcagcaag cggttttacc tttagcagct atccgatgag ctgggttcgt      840

caggcaccgg gtaaaggtcc ggcatgggtt agcaccgtta gtccgggtgg tattacaacc      900

agttatgcag atagcgttaa aggtcgtttt accattagcc gtgataatag caaaaatacc      960

ctgtatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtctgcgt     1020

gatctgggta atcgtggtca ggggaccctg gtcacggtct cgagcggagg cggtgggtca     1080

ggtggcggag gcagcggtgg aggaggtagt ggcggtggcg gtagtggggg tggaggcagc     1140

ggaggcggag gcagtggggg cggtggctca gaggtacaac tagtggagtc tgggggtggc     1200

ttggtgcaac cgggtaacag tctgcgcctt agctgcgcag cgtctggctt taccttcagc     1260

tcctttggca tgagctgggt tcgccaggct ccgggaaaag gactggaatg ggtttcgtct     1320

attagcggca gtggtagcga tacgctctac gcggactccg tgaagggccg tttcaccatc     1380

tcccgcgata acgccaaaac tacactgtat ctgcaaatga atagcctgcg tcctgaagac     1440

acggccgttt attactgtac tattggtggc tcgttaagcc gttcttcaca ggggaccctg     1500

gtcaccgtct cctca                                                      1515


<210>  427
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  427
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc aggaggtggc ggatccggcg gaggtagtga ggtgcagctg      660

gtggagtctg ggggtggctt ggtgcaaccg ggtaacagtc tgcgccttag ctgcgcagcg      720

tctggcttta ccttcagctc ctttggcatg agctgggttc gccaggctcc gggaaaagga      780

ctggaatggg tttcgtctat tagcggcagt ggtagcgata cgctctacgc ggactccgtg      840

aagggccgtt tcaccatctc ccgcgataac gccaaaacta cactgtatct gcaaatgaat      900

agcctgcgtc ctgaagacac ggccgtttat tactgtacta ttggtggctc gttaagccgt      960

tcttcacagg ggaccctggt cacggtctcc tcaggaggtg gcgggtccgg aggaggtagt     1020

gaggtgcagc tggtggagtc tgggggtggt ctggttcagc ctggtggtag cctgcgtctg     1080

agctgtgcag caagcggtcg tacctattat ctgaatgcaa tgggttggtt tcgtcaggca     1140

ccgggtaaag aacgtgaatt tgttgcagcc attgattgga gcgaaggcaa taaagattat     1200

gccgatagcg tgaaaggtcg ttttaccatt agccgtgatg ctagcaaaaa caccgtttat     1260

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtgc agcagatacc     1320

cctccgtggg gtccgctgat ttatattgaa agctatgata gctggggtca ggggaccctg     1380

gtcaccgtct cctca                                                      1395


<210>  428
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  428
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc aggaggtggc ggatccggcg gaggtagtga ggtgcagctg      660

gtggagtctg ggggtggtct ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca      720

agcggtcgta cctattatct gaatgcaatg ggttggtttc gtcaggcacc gggtaaagaa      780

cgtgaatttg ttgcagccat tgattggagc gaaggcaata aagattatgc cgatagcgtg      840

aaaggtcgtt ttaccattag ccgtgatgct agcaaaaaca ccgtttatct gcagatgaat      900

agcctgcgtc ctgaagatac cgcagtttat tattgtgcag cagatacccc tccgtggggt      960

ccgctgattt atattgaaag ctatgatagc tggggtcagg ggaccctggt cacggtctcc     1020

tcaggaggtg gcgggtccgg aggaggtagt gaggtgcagc tggtggagtc tgggggtggc     1080

ttggtgcaac cgggtaacag tctgcgcctt agctgcgcag cgtctggctt taccttcagc     1140

tcctttggca tgagctgggt tcgccaggct ccgggaaaag gactggaatg ggtttcgtct     1200

attagcggca gtggtagcga tacgctctac gcggactccg tgaagggccg tttcaccatc     1260

tcccgcgata acgccaaaac tacactgtat ctgcaaatga atagcctgcg tcctgaagac     1320

acggccgttt attactgtac tattggtggc tcgttaagcc gttcttcaca ggggaccctg     1380

gtcaccgtct cctca                                                      1395


<210>  429
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  429
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtcgtacct attatctgaa tgcaatgggt      360

tggtttcgtc aggcaccggg taaagaacgt gaatttgttg cagccattga ttggagcgaa      420

ggcaataaag attatgccga tagcgtgaaa ggtcgtttta ccattagccg tgatgctagc      480

aaaaacaccg tttatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtgcagcag atacccctcc gtggggtccg ctgatttata ttgaaagcta tgatagctgg      600

ggtcagggga ccctggtcac ggtctcctca ggaggtggcg gatccggcgg aggtagtgag      660

gtgcagctgg tggagtctgg gggtggcttg gtgcaaccgg gtaacagtct gcgccttagc      720

tgcgcagcgt ctggctttac cttcagctcc tttggcatga gctgggttcg ccaggctccg      780

ggaaaaggac tggaatgggt ttcgtctatt agcggcagtg gtagcgatac gctctacgcg      840

gactccgtga agggccgttt caccatctcc cgcgataacg ccaaaactac actgtatctg      900

caaatgaata gcctgcgtcc tgaagacacg gccgtttatt actgtactat tggtggctcg      960

ttaagccgtt cttcacaggg gaccctggtc acggtctcct caggaggtgg cgggtccgga     1020

ggaggtagtg aggtgcagct ggtggagtct gggggtggtc tggttcagcc tggtggtagc     1080

ctgcgtctga gctgtgcagc aagcggcacc ctgtttaaaa ttaatgcaat gggttggtat     1140

cgccaggcac cgggtaaacg tcgtgaactg gttgcactga ttaccagcag cgataccacc     1200

gattatgcag aagatgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1260

gtttatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtcacagc     1320

gatcattata gcctgggtgt gccggaaaaa cgtgttattc tgtatggtca ggggaccctg     1380

gtcaccgtct cctca                                                      1395


<210>  430
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  430
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtcgtacct attatctgaa tgcaatgggt      360

tggtttcgtc aggcaccggg taaagaacgt gaatttgttg cagccattga ttggagcgaa      420

ggcaataaag attatgccga tagcgtgaaa ggtcgtttta ccattagccg tgatgctagc      480

aaaaacaccg tttatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtgcagcag atacccctcc gtggggtccg ctgatttata ttgaaagcta tgatagctgg      600

ggtcagggga ccctggtcac ggtctcctca ggaggtggcg gatccggcgg aggtagtgag      660

gtgcagctgg tggagtctgg gggtggtctg gttcagcctg gtggtagcct gcgtctgagc      720

tgtgcagcaa gcggcaccct gtttaaaatt aatgcaatgg gttggtatcg ccaggcaccg      780

ggtaaacgtc gtgaactggt tgcactgatt accagcagcg ataccaccga ttatgcagaa      840

gatgttaaag gtcgctttac cattagccgt gataatagct ggaataccgt ttatctgcag      900

atgaatagcc tgcgtcctga agataccgca gtttattatt gtcacagcga tcattatagc      960

ctgggtgtgc cggaaaaacg tgttattctg tatggtcagg ggaccctggt cacggtctcc     1020

tcaggaggtg gcgggtccgg aggaggtagt gaggtgcagc tggtggagtc tgggggtggc     1080

ttggtgcaac cgggtaacag tctgcgcctt agctgcgcag cgtctggctt taccttcagc     1140

tcctttggca tgagctgggt tcgccaggct ccgggaaaag gactggaatg ggtttcgtct     1200

attagcggca gtggtagcga tacgctctac gcggactccg tgaagggccg tttcaccatc     1260

tcccgcgata acgccaaaac tacactgtat ctgcaaatga atagcctgcg tcctgaagac     1320

acggccgttt attactgtac tattggtggc tcgttaagcc gttcttcaca ggggaccctg     1380

gtcaccgtct cctca                                                      1395


<210>  431
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  431
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagaaga tgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc aggaggtggc ggatccggcg gaggtagtga ggtgcagctg      660

gtggagtctg ggggtggctt ggtgcaaccg ggtaacagtc tgcgccttag ctgcgcagcg      720

tctggcttta ccttcagctc ctttggcatg agctgggttc gccaggctcc gggaaaagga      780

ctggaatggg tttcgtctat tagcggcagt ggtagcgata cgctctacgc ggactccgtg      840

aagggccgtt tcaccatctc ccgcgataac gccaaaacta cactgtatct gcaaatgaat      900

agcctgcgtc ctgaagacac ggccgtttat tactgtacta ttggtggctc gttaagccgt      960

tcttcacagg ggaccctggt cacggtctcc tcaggaggtg gcgggtccgg aggaggtagt     1020

gaggtgcagc tggtggagtc tgggggtggt ctggttcagc ctggtggtag cctgcgtctg     1080

agctgtgcag caagcggtag cattggtggt ctgaatgcaa tggcatggta tcgtcaggca     1140

ccgggtaaag aacgtgaact ggttgcaggt atttttggtg ttggtagcac ccgttatgca     1200

gatagcgtta aaggtcgttt taccattagc cgtgacaata gcaaaaacac cgtttatctg     1260

cagatgaata gcctgcgtcc tgaagatacc gcagtttatt attgtcgcat gagcagcgtt     1320

acccgtggta gcagcgatta ttggggtcag gggaccctgg tcaccgtctc ctca           1374


<210>  432
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  432
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtcct gaatgggtta gcaccgttag tccgggtgga      420

attaccacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctcaggaggt      600

ggcggatccg gcggaggtag tgaggtgcag ctggtggagt ctgggggtgg cttggtgcaa      660

ccgggtaaca gtctgcgcct tagctgcgca gcgtctggct ttaccttcag ctcctttggc      720

atgagctggg ttcgccaggc tccgggaaaa ggactggaat gggtttcgtc tattagcggc      780

agtggtagcg atacgctcta cgcggactcc gtgaagggcc gtttcaccat ctcccgcgat      840

aacgccaaaa ctacactgta tctgcaaatg aatagcctgc gtcctgaaga cacggccgtt      900

tattactgta ctattggtgg ctcgttaagc cgttcttcac aggggaccct ggtcacggtc      960

tcctcaggag gtggcgggtc cggaggaggt agtgaggtgc agctggtgga gtctgggggt     1020

ggtctggttc agcctggtgg tagcctgcgt ctgagctgtg cagcaagcgg caccctgttt     1080

aaaattaatg caatgggttg gtatcgccag gcaccgggta aacgtcgtga actggttgca     1140

ctgattacca gcagcgatac caccgattat gcagaagatg ttaaaggtcg ctttaccatt     1200

agccgtgata atagctggaa taccgtttat ctgcagatga atagcctgcg tcctgaagat     1260

accgcagttt attattgtca cagcgatcat tatagcctgg gtgtgccgga aaaacgtgtt     1320

attctgtatg gtcaggggac cctggtcacc gtctcctca                            1359


<210>  433
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  433
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc      720

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt      780

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc      840

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct      900

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggg      960

accctggtca ccgtctcctc a                                                981


<210>  434
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  434
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtcgtacct attatctgaa tgcaatgggt      360

tggtttcgtc aggcaccggg taaagaacgt gaatttgttg cagccattga ttggagcgaa      420

ggcaataaag attatgccga tagcgtgaaa ggtcgtttta ccattagccg tgataacagc      480

aaaaacaccg tttatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtgcagcag atacccctcc gtggggtccg ctgatttata ttgaaagcta tgatagctgg      600

ggtcagggga ccctggtcac ggtctcctca ggaggtggcg gatccggcgg aggtagtgag      660

gtgcagctgg tggagtctgg gggtggcttg gtgcaaccgg gtaacagtct gcgccttagc      720

tgcgcagcgt ctggctttac cttcagctcc tttggcatga gctgggttcg ccaggctccg      780

ggaaaaggac tggaatgggt ttcgtctatt agcggcagtg gtagcgatac gctctacgcg      840

gactccgtga agggccgttt caccatctcc cgcgataacg ccaaaactac actgtatctg      900

caaatgaata gcctgcgtcc tgaagacacg gccgtttatt actgtactat tggtggctcg      960

ttaagccgtt cttcacaggg gaccctggtc acggtctcct caggaggtgg cgggtccgga     1020

ggaggtagtg aggtgcagct ggtggagtct gggggtggtc tggttcagcc tggtggtagc     1080

ctgcgtctga gctgtgcagc aagcggcacc ctgtttaaaa ttaatgcaat gggttggtat     1140

cgccaggcac cgggtaaacg tcgtgaactg gttgcactga ttaccagcag cgataccacc     1200

gattatgcag aagatgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1260

gtttatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtcacagc     1320

gatcattata gcctgggtgt gccggaaaaa cgtgttattc tgtatggtca ggggaccctg     1380

gtcaccgtct cctca                                                      1395


<210>  435
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  435
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctgggggt ggtctggttc agcctggtgg tagcctgcgt      120

ctgagctgtg cagcaagcgg caccctgttt aaaattaatg caatgggttg gtatcgccag      180

gcaccgggta aacgtcgtga actggttgca ctgattacca gcagcgatac caccgattat      240

gcagatagcg ttaaaggtcg ctttaccatt agccgtgata atagctggaa taccgtttat      300

ctgcagatga atagcctgcg tcctgaagat accgcagttt attattgtca cagcgatcat      360

tatagcctgg gtgtgccgga aaaacgtgtt attctgtatg gtcaggggac cctggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  436
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  436
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagacgt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtagcattg gtggtctgaa tgcaatggca      360

tggtatcgtc aggcaccggg taaagaacgt gaactggttg caggtatttt tggtgttggt      420

agcacccgtt atgcagatag cgttaaaggt cgttttacca ttagccgtga caatagcaaa      480

aacaccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cgcatgagca gcgttacccg tggtagcagc gattattggg gtcaggggac cctggtcacg      600

gtctcctcag gaggtggcgg atccggcgga ggtagtgagg tgcagctggt ggagtctggg      660

ggtggcttgg tgcaaccggg taacagtctg cgccttagct gcgcagcgtc tggctttacc      720

ttcagctcct ttggcatgag ctgggttcgc caggctccgg gaaaaggact ggaatgggtt      780

tcgtctatta gcggcagtgg tagcgatacg ctctacgcgg actccgtgaa gggccgtttc      840

accatctccc gcgataacgc caaaactaca ctgtatctgc aaatgaatag cctgcgtcct      900

gaagacacgg ccgtttatta ctgtactatt ggtggctcgt taagccgttc ttcacagggg      960

accctggtca cggtctcctc aggaggtggc gggtccggag gaggtagtga ggtgcagctg     1020

gtggagtctg ggggtggtct ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca     1080

agcggcaccc tgtttaaaat taatgcaatg ggttggtatc gccaggcacc gggtaaacgt     1140

cgtgaactgg ttgcactgat taccagcagc gataccaccg attatgcaga tagcgttaaa     1200

ggtcgcttta ccattagccg tgataatagc tggaataccg tttatctgca gatgaatagc     1260

ctgcgtcctg aagataccgc agtttattat tgtcacagcg atcattatag cctgggtgtg     1320

ccggaaaaac gtgttattct gtatggtcag gggaccctgg tcaccgtctc ctca           1374


<210>  437
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  437
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcagcta tccgatgagc      360

tgggttcgtc aggcaccggg taaaggtcct gaatgggtta gcaccgttag tccgggtgga      420

attaccacca gttatgcaga tagcgttaaa ggtcgtttta ccattagccg tgataatagc      480

aaaaataccc tgtatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtctgcgtg atctgggtaa tcgtggtcag gggaccctgg tcacggtctc ctcaggaggt      600

ggcggatccg gcggaggtag tgaggtgcag ctggtggagt ctgggggtgg cttggtgcaa      660

ccgggtaaca gtctgcgcct tagctgcgca gcgtctggct ttaccttcag ctcctttggc      720

atgagctggg ttcgccaggc tccgggaaaa ggactggaat gggtttcgtc tattagcggc      780

agtggtagcg atacgctcta cgcggactcc gtgaagggcc gtttcaccat ctcccgcgat      840

aacgccaaaa ctacactgta tctgcaaatg aatagcctgc gtcctgaaga cacggccgtt      900

tattactgta ctattggtgg ctcgttaagc cgttcttcac aggggaccct ggtcacggtc      960

tcctcaggag gtggcgggtc cggaggaggt agtgaggtgc agctggtgga gtctgggggt     1020

ggtctggttc agcctggtgg tagcctgcgt ctgagctgtg cagcaagcgg caccctgttt     1080

aaaattaatg caatgggttg gtatcgccag gcaccgggta aacgtcgtga actggttgca     1140

ctgattacca gcagcgatac caccgattat gcagatagcg ttaaaggtcg ctttaccatt     1200

agccgtgata atagctggaa taccgtttat ctgcagatga atagcctgcg tcctgaagat     1260

accgcagttt attattgtca cagcgatcat tatagcctgg gtgtgccgga aaaacgtgtt     1320

attctgtatg gtcaggggac cctggtcacc gtctcctca                            1359


<210>  438
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  438
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggtcgtacct attatctgaa tgcaatgggt      360

tggtttcgtc aggcaccggg taaagaacgt gaatttgttg cagccattga ttggagcgaa      420

ggcaataaag attatgccga tagcgtgaaa ggtcgtttta ccattagccg tgataacagc      480

aaaaacaccg tttatctgca gatgaatagc ctgcgtcctg aagataccgc agtttattat      540

tgtgcagcag atacccctcc gtggggtccg ctgatttata ttgaaagcta tgatagctgg      600

ggtcagggga ccctggtcac ggtctcctca ggaggtggcg gatccggcgg aggtagtgag      660

gtgcagctgg tggagtctgg gggtggcttg gtgcaaccgg gtaacagtct gcgccttagc      720

tgcgcagcgt ctggctttac cttcagctcc tttggcatga gctgggttcg ccaggctccg      780

ggaaaaggac tggaatgggt ttcgtctatt agcggcagtg gtagcgatac gctctacgcg      840

gactccgtga agggccgttt caccatctcc cgcgataacg ccaaaactac actgtatctg      900

caaatgaata gcctgcgtcc tgaagacacg gccgtttatt actgtactat tggtggctcg      960

ttaagccgtt cttcacaggg gaccctggtc acggtctcct caggaggtgg cgggtccgga     1020

ggaggtagtg aggtgcagct ggtggagtct gggggtggtc tggttcagcc tggtggtagc     1080

ctgcgtctga gctgtgcagc aagcggcacc ctgtttaaaa ttaatgcaat gggttggtat     1140

cgccaggcac cgggtaaacg tcgtgaactg gttgcactga ttaccagcag cgataccacc     1200

gattatgcag atagcgttaa aggtcgcttt accattagcc gtgataatag ctggaatacc     1260

gtttatctgc agatgaatag cctgcgtcct gaagataccg cagtttatta ttgtcacagc     1320

gatcattata gcctgggtgt gccggaaaaa cgtgttattc tgtatggtca ggggaccctg     1380

gtcaccgtct cctca                                                      1395


<210>  439
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  439
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaaa agagagaggt gcaattggtg gagtctgggg gtggtctggt tcagcctggt      300

ggtagcctgc gtctgagctg tgcagcaagc ggcaccctgt ttaaaattaa tgcaatgggt      360

tggtatcgcc aggcaccggg taaacgtcgt gaactggttg cactgattac cagcagcgat      420

accaccgatt atgcagatag cgttaaaggt cgctttacca ttagccgtga taatagctgg      480

aataccgttt atctgcagat gaatagcctg cgtcctgaag ataccgcagt ttattattgt      540

cacagcgatc attatagcct gggtgtgccg gaaaaacgtg ttattctgta tggtcagggg      600

accctggtca cggtctcctc aggaggtggc ggatccggcg gaggtagtga ggtgcagctg      660

gtggagtctg ggggtggctt ggtgcaaccg ggtaacagtc tgcgccttag ctgcgcagcg      720

tctggcttta ccttcagctc ctttggcatg agctgggttc gccaggctcc gggaaaagga      780

ctggaatggg tttcgtctat tagcggcagt ggtagcgata cgctctacgc ggactccgtg      840

aagggccgtt tcaccatctc ccgcgataac gccaaaacta cactgtatct gcaaatgaat      900

agcctgcgtc ctgaagacac ggccgtttat tactgtacta ttggtggctc gttaagccgt      960

tcttcacagg ggaccctggt cacggtctcc tcaggaggtg gcgggtccgg aggaggtagt     1020

gaggtgcagc tggtggagtc tgggggtggt ctggttcagc ctggtggtag cctgcgtctg     1080

agctgtgcag caagcggtag cattggtggt ctgaatgcaa tggcatggta tcgtcaggca     1140

ccgggtaaag aacgtgaact ggttgcaggt atttttggtg ttggtagcac ccgttatgca     1200

gatagcgtta aaggtcgttt taccattagc cgtgacaata gcaaaaacac cgtttatctg     1260

cagatgaata gcctgcgtcc tgaagatacc gcagtttatt attgtcgcat gagcagcgtt     1320

acccgtggta gcagcgatta ttggggtcag gggaccctgg tcaccgtctc ctca           1374


<210>  440
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  440
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc aggctggggg gtctctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtagctatc ccatgagctg ggtccgccag      180

gctccaggaa aggggcccgc gtgggtctca actgttagtc ctggtggtat aaccacaagc      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacgctg      300

tatttgcaaa tgaacagcct gaaacctgag gacacggccg tgtattactg cttaagagat      360

ctgaataata ggggccaggg gacccaggtc accgtctcct cagcggccgc agaacaaaaa      420

ctcatctcag aagaggatct gaatggggcc gcacatcatc atcatcatca t               471


<210>  441
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  441
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc aacctggggg gtctctgaga      120

ctctcctgcg cagcctctgg aagcatcggc ggtctcaatg ccatggcctg gtaccgccag      180

gctccaggaa aagagcgcga gttggtcgca ggtatttttg gcgttggtag cacgaggtac      240

gcggactccg tgaagggccg attcaccatc tctagagaca tcgccaagaa cacggtgttt      300

ctgcaaatga acagcctgaa ttctgaggac acggccgttt attactgtcg gatgtcaagt      360

gttactcgtg gtagttctga ctactggggt caggggaccc aggtcaccgt ctcctcagcg      420

gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaca tcatcatcat      480

catcat                                                                 486


<210>  442
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  442
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aacgctcttc aaaatcaacg ccatgggctg gtaccgccag      180

gctccaggga agcggcgcga gttggtcgca cttattacta gtagcgatac aacggattat      240

gcagagtccg tggagggccg attcaccatc tccagagaca acacgtggaa cgcggtgtat      300

ctgcaaatga acagtctgaa acctgaggat acggccgtct attactgtca ctcagatcat      360

tactcgatgg gtgtgcctga aaagcgagtc ataatgtacg gccaggggac ccaggtcacc      420

gtctcctcag cggccgcaga acaaaaactc atctcagaag aggatctgaa tggggccgca      480

catcatcatc atcatcat                                                    498


<210>  443
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  443
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcacgtac tatctcaatg ccatgggctg gttccgccag      180

ggtccaggga aggaccgtga gtttgtagca gctatagact ggagtgatgg taacaaagac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagccgac      360

acaccaccct gggggcctat gatctacatc gaatcgtatg actcctgggg ccaggggacc      420

caggtcaccg tctcctcagc ggccgcagaa caaaaactca tctcagaaga ggatctgaat      480

ggggccgcac atcatcatca tcatcat                                          507


<210>  444
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  444
atgaaaaaga ccgctatcgc gattgcagtg gcactggctg gtttggccac cgtggcccag       60

gccgaggtgc aattggtgga gtctggggga ggcttggtgc agcctggggg gtctctggga      120

ctctcctgtg tagcctctgg aagcatcttc agaatcaatg ccatggcctg gtaccgccag      180

gctccaggga agcagcgcga gttggtcgcg gaaattactg ctggtggtag cacaaactat      240

gcagactccg tgaagggccg attcaccatc tccgtagaca acgcctggaa cacgctgtat      300

ctgcaaatga acagcctgaa agttgaggac acggccgtct attactgtaa tctagatcat      360

tatacgacat gggatagacg gagtgcctac tggggccagg ggacccaggt caccgtctcc      420

tcagcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgcacatcat      480

catcatcatc at                                                          492


