
                                SEQUENCE LISTING

<110> AVI BioPharma, Inc.
      Schnell, Frederick J.
      Iversen, Patrick L.
      Mourich, Dan V.

<120> ANTISENSE MODULATION OF INTERLEUKINS 17
  AND 23 SIGNALING

<130> 120178.486PC

<140> PCT                 
<141> 2011-05-13  

<150> US 61/334,516       
<151> 2010-05-13  

<160> 36

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 611
<212> DNA
<213> Homo sapiens

<400> 1
tccccactgt ccagcagagg gccaggcaca tgcccatgga ggggacctga gcagaccccc 60
atttcctttc caggtgtggc ctctggaacc tgactccgtt aggacgaaca tctgcccctt 120
cagggagggt gagccgaccg gcctggggct ggggttgggg tgttgcgagc gatgggtacc 180
tggcctgcgg tgactgtgcc ctttccttgc agacccccgc gcacaccaga acctctggca 240
agccgcccga ctgcaactgc tgaccctgca gagctggctg ctggacgcac cgtgctcgct 300
gcccgcagaa gcggcactgt gctggcgggc tccgggtggg gacccctgcc agccactggt 360
cccaccgctt tcctgggaga acgtcactgt ggacgtaagt gaagcagagg gcacctcccg 420
tggtgagggg agagtgggga accgggggtc cccttttgtg atcccaccca ttcctctctt 480
tccacagaag gttctcgagt tcccattgct gaaaggccac cctaacctct gtgttcaggt 540
cagaaagggg tgcatagtgc tgggctggag gctggacctg ggcagacccc ccagccaagg 600
gggtcttagt t                                                      611

<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 2
caccctccct gaaggggcag atgt                                        24

<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 3
agaggttctg gtgtgcgcgg gggt                                        24

<210> 4
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 4
tccccacccg gagcccgcca gcac                                        24

<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 5
gtccacagtg acgttctccc agga                                        24

<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 6
ctgcttcact tacgtccaca gtga                                        24

<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 7
actcgagaac cttctgtgga aaga                                        24

<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 8
ctgaacacag aggttagggt ggcc                                        24

<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 9
atgcacccct ttctgacctg aaca                                        24

<210> 10
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 10
ccagcccagc actatgcacc cctt                                        24

<210> 11
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 11
ctgaacacag aggttag                                                17

<210> 12
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 12
ctggacacag aggttgg                                                17

<210> 13
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 13
tctgacctga acacagaggt ta                                          22

<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antisense targeting sequence for inducing exon
      skipping

<400> 14
tctgacctgg acacagaggt tg                                          22

<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 15
Arg Arg Arg Gln Arg Arg Lys Lys Arg Cys
 1               5                  10  


<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 16
Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe Cys
 1               5                  10          


<210> 17
<211> 13
<212> PRT
<213> Artifcial Sequence

<220> 
<221> MOD_RES        
<222> 3, 6, 9, 12
<223> Acp

<220> 
<221> MOD_RES        
<222> 13
<223> bAla

<400> 17
Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Xaa
 1               5                  10              


<210> 18
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 14
<223> bAla

<400> 18
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa
 1               5                  10                  


<210> 19
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 1, 4, 7, 10, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 14
<223> bAla

<400> 19
Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Xaa
 1               5                  10                  


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 4, 6, 8, 10, 12
<223> Acp

<220> 
<221> MOD_RES        
<222> 13
<223> bAla

<400> 20
Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Xaa
 1               5                  10              


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 4, 6, 8, 10, 12, 14
<223> Acp

<220> 
<221> MOD_RES        
<222> 15
<223> bAla

<400> 21
Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Xaa
 1               5                  10                  15  


<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 5, 8, 11, 14, 16
<223> Acp

<220> 
<221> MOD_RES        
<222> 17
<223> bAla

<400> 22
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa
 1               5                  10                  15      
Xaa
    


<210> 23
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 8, 13
<223> Acp

<220> 
<221> MOD_RES        
<222> 5, 11, 14
<223> bAla

<400> 23
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa
 1               5                  10                  


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 24
Arg Arg Arg Arg Arg Arg Gly
 1               5          


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 25
Arg Arg Arg Arg Arg Arg Arg Gly
 1               5              


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 26
Arg Arg Arg Arg Arg Arg Arg Arg Gly
 1               5                  


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 27
Arg Arg Arg Arg Arg Gly Arg Arg Arg Arg Gly
 1               5                  10      


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 28
Arg Arg Arg Arg Arg Phe Phe Arg Arg Arg Arg Gly
 1               5                  10          


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 29
Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly
 1               5                  10  


<210> 30
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<400> 30
Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly
 1               5                  10  


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 8
<223> Acp

<400> 31
Arg Xaa Arg Arg Gly Gly Arg Xaa Arg Arg Gly Gly
 1               5                  10          


<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> MOD_RES        
<222> 2, 6, 8, 12
<223> Acp

<400> 32
Arg Xaa Arg Arg Arg Xaa Arg Xaa Arg Arg Arg Xaa Gly
 1               5                  10              


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> VARIANT        
<222> 1, 3, 4, 7, 9, 10
<223> Xaa = Lysine, Arginine or Arginine analog
      

<220> 
<221> VARIANT        
<222> 2, 8
<223> Xaa = a neutral amino acid, -C(O)-(CHR)n-NH-,
      where n is 2 to 7 and R is H or methyl

<220> 
<221> VARIANT        
<222> 5, 6, 11, 12
<223> Xaa = alpha-amino acid having a neutral aralkyl
      side chain

<400> 33
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10          


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> VARIANT        
<222> 2, 6, 8, 12
<223> Xaa = Gly or Acp

<400> 34
Arg Xaa Arg Arg Arg Xaa Arg Xaa Arg Arg Arg Xaa
 1               5                  10          


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cell penetrating peptide

<220> 
<221> VARIANT        
<222> 3, 5, 9
<223> Xaa = Gly or Acp

<400> 35
Arg Arg Xaa Arg Xaa Arg Arg Arg Xaa
 1               5                  


<210> 36
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide loop insert

<400> 36
Cys Gly Pro Cys
 1              

