                         SEQUENCE LISTING

<110>  RINAT NEUROSCIENCE CORP.
 
<120>  HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING 
       THEM

<130>  PC71659A

<150>  US 61/345,047
<151>  2010-05-14

<150>  US 61/485,097
<151>  2011-05-11

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lgG2 Delta A Fc region sequence

<400>  1
gcctccacca agggcccatc tgtcttccca ctggccccat gctcccgcag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc cagaacctgt gaccgtgtcc      120

tggaactctg gcgctctgac cagcggcgtg cacaccttcc cagctgtcct gcagtcctca      180

ggtctctact ccctcagcag cgtggtgacc gtgccatcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagccaagc aacaccaagg tcgacaagac cgtggagaga      300

aagtgttgtg tggagtgtcc accttgtcca gcccctccag tggccggacc atccgtgttc      360

ctgttccctc caaagccaaa ggacaccctg atgatctcca gaaccccaga ggtgacctgt      420

gtggtggtgg acgtgtccca cgaggaccca gaggtgcagt tcaactggta tgtggacgga      480

gtggaggtgc acaacgccaa gaccaagcca agagaggagc agttcaactc caccttcaga      540

gtggtgagcg tgctgaccgt ggtgcaccag gactggctga acggaaagga gtataagtgt      600

aaggtgtcca acaagggact gccatccagc atcgagaaga ccatctccaa gaccaaggga      660

cagccaagag agccacaggt gtataccctg cccccatcca gagaggagat gaccaagaac      720

caggtgtccc tgacctgtct ggtgaaggga ttctatccat ccgacatcgc cgtggagtgg      780

gagtccaacg gacagccaga gaacaactat aagaccaccc ctccaatgct ggactccgac      840

ggatccttct tcctgtattc caagctgacc gtggacaagt ccagatggca gcagggaaac      900

gtgttctctt gttccgtgat gcacgaggcc ctgcacaacc actataccca gaagagcctg      960

tccctgtctc cgggtaaata ggcggccgc                                        989


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  2
gcctccacca agggcccatc                                                   20


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  3
ctttctctcc acggtcttg                                                    19


<210>  4
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  4
acaagaccgt ggagagaaag tgtgasgtgg agtgtccaar gtgtccagcc cctccagtgg       60


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  5
atacaagcgg ccgcctattt acccggagac aggga                                  35


<210>  6
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  6
acaagaccgt ggagagaaag tgtgasgtgg agtgtccaga stgtccagcc cctccagtgg       60


<210>  7
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  7
acaagaccgt ggagagaaag tgtgasgtga rgtgtccaga stgtccagcc cctccagtgg       60


<210>  8
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  8
acaagaccgt ggagagaaag tgtarggtga rgtgtccaga stgtccagcc cctccagtgg       60


<210>  9
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  9
acaagaccgt ggagagaaag tgtarggtga rgtgtccaar gtgtccagcc cctccagtgg       60


<210>  10
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  10
acaagaccgt ggagagaaag tgtarggtgg agtgtccaar gtgtccagcc cctccagtgg       60


<210>  11
<211>  1000
<212>  DNA
<213>  Homo Sapiens

<220>
<223>  IgG1 Fc wild-type region sequence

<400>  11
gcgtccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tcgacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcag gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa tagcggccgc                           1000


<210>  12
<211>  1000
<212>  DNA
<213>  Homo Sapiens

<220>
<223>  IgG4 wild-type Fc region sequence

<400>  12
gcgtccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tcgacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcag gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa tagcggccgc                           1000


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  13
gcctccacca agggcccatc                                                   20


<210>  14
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  14
atacaagcgg ccgcctattt acccagagac agggaga                                37


<210>  15
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  15
gagtccaaat atggtccccc atgcccaarg tgcccagcac ctgagttcct                  50


<210>  16
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  16
gagtccaaat atggtccccc atgcccagas tgcccagcac ctgagttcct                  50


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  17
tgggggacca tatttggact                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  18
gcctccacca agggcccatc                                                   20


<210>  19
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  19
atacaagcgg ccgcctattt acccggagac aggga                                  35


<210>  20
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  20
gaaagttgag cccaaatctt gtgagaaaac tcacacatgc ccagagtgcc cagcacctga       60

actcc                                                                   65


<210>  21
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  21
gaaagttgag cccaaatctt gtaggaaaac tcacacatgc ccaaggtgcc cagcacctga       60

actcc                                                                   65


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  22
acaagatttg ggctcaactt tc                                                22


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  23
ccccgagaac cagaggtgta caccctg                                           27


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  24
cagggtgtac acctctggtt ctcgggg                                           27


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  25
gagaaccaca ggtggagacc ctgcccccat                                        30


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  26
atgggggcag ggtctccacc tgtggttctc                                        30


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  27
aaccacaggt gtacgagctg cccccatccc                                        30


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  28
gggatggggg cagctcgtac acctgtggtt                                        30


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  29
cacaggtgta caccgagccc ccatcccggg                                        30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  30
cccgggatgg gggctcggtg tacacctgtg                                        30


<210>  31
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  31
ccaggtcagc ctggagtgcc tggtcaaagg                                        30


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  32
cctttgacca ggcactccag gctgacctgg                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  33
cagcctgacc tgcgaggtca aaggcttcta                                        30


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  34
tagaagcctt tgacctcgca ggtcaggctg                                        30


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  35
tgacctgcct ggtcgagggc ttctatccca                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  36
tgggatagaa gccctcgacc aggcaggtca                                        30


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  37
ggagaacaac tacgagacca cgcctcccgt                                        30


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  38
acgggaggcg tggtctcgta gttgttctcc                                        30


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  39
caactacaag accgagcctc ccgtgctgga                                        30


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  40
tccagcacgg gaggctcggt cttgtagttg                                        30


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  41
gaccacgcct cccgagctgg actccgacgg                                        30


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  42
ccgtcggagt ccagctcggg aggcgtggtc                                        30


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  43
acgcctcccg tggaggactc cgacggctcc                                        30


<210>  44
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  44
ggagccgtcg gagtcctcca cgggaggcgt                                        30


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  45
gacggctcct tcgagctgta cagcaagctc                                        30


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  46
gagcttgctg tacagctcga aggagccgtc                                        30


<210>  47
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  47
ctccttcttc ctcgagagca agctcaccg                                         29


<210>  48
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  48
cggtgagctt gctctcgagg aagaaggag                                         29


<210>  49
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  49
ttcctctaca gcgagctgac cgtggacaag a                                      31


<210>  50
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  50
tcttgtccac ggtcagctcg ctgtagagga a                                      31


<210>  51
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  51
ttcctctaca gcaggctgac cgtggacaag a                                      31


<210>  52
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  52
tcttgtccac ggtcagcctg ctgtagagga a                                      31


<210>  53
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus 3xFLAG tag

<400>  53

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys Gly Leu Glu 
            20                  25  


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus HA tag

<400>  54

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Glu 
1               5                   10      


