                         SEQUENCE LISTING

<110>  THE GENERAL HOSPITAL CORPORATION
       CHUGAI SEIYAKU KABUSHIKI KAISHA
       GARDELLA, Thomas J
       POTTS, John T
       JUPPNER, Harald
       OKAZAKI, Makoto
 
<120>  PARATHYROID HORMONE ANALOGS AND USES THEREOF

<130>  00786/563WO3

<140>  PCT/US2011/036222
<141>  2011-05-12

<150>  US 61/415,141
<151>  2010-11-18

<150>  US 61/334,319
<151>  2010-05-13

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ser, Ala, or Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ser, Ala, or Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Met, Leu, or Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Asn, Ala, Val, Asp, Glu, or Gln

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Leu, Ala, Val, Met, Lys, Ile, Arg, Har, or Trp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Gly, Ala, His, or Arg

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Lys, Ala, Leu, Gln, Arg, His, or Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  His, Leu, Arg, Phe, Trp, or Ser

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Ile or Leu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Gln or Asn

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Asp or Ser

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala, Leu, Met, Glu, Ser, or Phe

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Ala, Phe, Glu, Ser, Leu, Asn, Trp, or Lys

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  His, Arg, Leu, Trp, or Lys

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys, His, Ala, Ser, Asn, or Arg

<400>  1

Xaa Val Xaa Glu Ile Gln Leu Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Arg Arg Arg Xaa Phe Leu Xaa Xaa Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  2
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ser, Ala, or Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ser, Ala, or Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Met, Leu, or Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Asn, Gln, or Asp

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Leu, Arg, Har, or Lys

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Gly or Ala

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  His, Trp, or Ser

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Ile or Leu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Gln or Asn

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Asp or Ser

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Leu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Ala or Phe

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys or His

<400>  2

Xaa Val Xaa Glu Ile Gln Leu Xaa His Xaa Xaa Xaa Lys Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Arg Arg Arg Xaa Phe Leu His Xaa Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  3
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ser, Ala, or Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ser, Ala, or Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Met, Leu, or Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Asn or Gln

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Leu, Arg, or Har

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Gly or Ala

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  His or Trp

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Gln or Asn

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Asp or Ser

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Leu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Ala or Phe

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Lys or His

<400>  3

Xaa Val Xaa Glu Ile Gln Leu Xaa His Xaa Xaa Xaa Lys Xaa Ile Xaa 
1               5                   10                  15      


Xaa Xaa Arg Arg Arg Xaa Phe Leu His Xaa Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  4
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Ala Arg Arg Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  5
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Har

<400>  5

Ala Val Xaa Glu Ile Gln Leu Met His Gln Xaa Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Ala Arg Arg Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  6
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Nle

<400>  6

Ala Val Ala Glu Ile Gln Leu Xaa His Gln Arg Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Ala Arg Arg Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Ala Arg Arg Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Har

<400>  8

Ala Val Xaa Glu Ile Gln Leu Xaa His Gln Xaa Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Ala Arg Arg Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Har

<400>  9

Ala Val Xaa Glu Ile Gln Leu Leu His Gln Xaa Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Ala Arg Arg Arg Ala Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  10
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  12
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Har

<400>  12

Ala Val Xaa Glu Ile Gln Leu Met His Gln Xaa Ala Lys Trp Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  13
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Har

<400>  13

Ala Val Xaa Glu Ile Gln Leu Met His Gln Xaa Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  14
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Nle

<400>  15

Ser Glu Ile Gln Phe Xaa His Asn Leu Gly Lys His Leu Ser Ser Xaa 
1               5                   10                  15      


Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Tyr 
            20                  25                  30          


