                         SEQUENCE LISTING

<110>  Timothy Osslund
 
<120>  High Concentration Antibody Formulations

<130>  31173/45219A

<140>  US-61/334,986
<141>  2010-05-14

<160>  248   

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-A & Ab-1 LCDR1

<400>  1

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala 
1               5                   10              


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-A and Ab-1 LCDR2

<400>  2

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-A and Ab-1 LCDR3

<400>  3

Gln Gly Ala Tyr Asn Asp Val Ile Tyr Ala 
1               5                   10  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-A and Ab-1 HCDR1

<400>  4

Ser Tyr Trp Met Asn 
1               5   


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-1 and Ab-2 HCDR2

<400>  5

Thr Ile Asp Ser Gly Gly Arg Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-A and Ab-1 HCDR3

<400>  6

Asn Trp Asn Leu 
1               


<210>  7
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit-Mouse Chimera


<220>
<221>  misc_feature
<223>  Ab-A light chain (no signal)

<400>  7
gcgcaagtgc tgacccagac tccagcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat gataacaact ggttagcctg gtttcagcag      120

aaaccagggc agcctcccaa gctcctgatt tatgatgcat ccgatctggc atctggggtc      180

ccatcgcggt tcagtggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgccg atgctgccac ttactactgt caaggcgctt ataatgatgt tatttatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggatg ctgcaccaac tgtatccatc      360

ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg cttcttgaac      420

aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga acgacaaaat      480

ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag catgagcagc      540

accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg tgaggccact      600

cacaagacat caacttcacc cattgtcaag agcttcaaca ggaatgagtg ttag            654


<210>  8
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit-Mouse Chimera


<220>
<221>  MISC_FEATURE
<223>  Ab-A light chain (no signal)

<400>  8

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Trp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Ala Tyr Asn Asp 
                85                  90                  95      


Val Ile Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
        115                 120                 125             


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
145                 150                 155                 160 


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
            180                 185                 190         


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
        195                 200                 205             


Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215         


<210>  9
<211>  1302
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Antibody


<220>
<221>  misc_feature
<223>  Ab-A heavy chain (no signal)

<400>  9
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagtagt tattggatga actgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaaccatt gattctggtg gtaggacgga ctacgcgagc      180

tgggcaaaag gccgattcac catctccaga acctcgacta cgatggatct gaaaatgacc      240

agtctgacga ccggggacac ggcccgttat ttctgtgcca gaaattggaa cttgtggggc      300

caaggcaccc tcgtcaccgt ctcgagcgct tctacaaagg gcccatctgt ctatccactg      360

gcccctggat ctgctgccca aactaactcc atggtgaccc tgggatgcct ggtcaagggc      420

tatttccctg agccagtgac agtgacctgg aactctggat ccctgtccag cggtgtgcac      480

accttcccag ctgtcctgca gtctgacctc tacactctga gcagctcagt gactgtcccc      540

tccagcacct ggcccagcga gaccgtcacc tgcaacgttg cccacccggc cagcagcacc      600

aaggtggaca agaaaattgt gcccagggat tgtggttgta agccttgcat atgtacagtc      660

ccagaagtat catctgtctt catcttcccc ccaaagccca aggatgtgct caccattact      720

ctgactccta aggtcacgtg tgttgtggta gacatcagca aggatgatcc cgaggtccag      780

ttcagctggt ttgtagatga tgtggaggtg cacacagctc agacgcaacc ccgggaggag      840

cagttcaaca gcactttccg ctcagtcagt gaacttccca tcatgcacca ggactggctc      900

aatggcaagg agttcaaatg cagggtcaac agtgcagctt tccctgcccc catcgagaaa      960

accatctcca aaaccaaagg cagaccgaag gctccacagg tgtacaccat tccacctccc     1020

aaggagcaga tggccaagga taaagtcagt ctgacctgca tgataacaga cttcttccct     1080

gaagacatta ctgtggagtg gcagtggaat gggcagccag cggagaacta caagaacact     1140

cagcccatca tggacacaga tggctcttac ttcgtctaca gcaagctcaa tgtgcagaag     1200

agcaactggg aggcaggaaa tactttcacc tgctctgtgt tacatgaggg cctgcacaac     1260

caccatactg agaagagcct ctcccactct cctggtaaat ga                        1302


<210>  10
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  MISC_FEATURE
<223>  Ab-A heavy chain (no signal)

<400>  10

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Trp 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Ile Asp Ser Gly Gly Arg Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Met Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Gly Asp Thr Ala Arg Tyr Phe Cys Ala Arg Asn Trp 
                85                  90                  95      


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
        115                 120                 125             


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
                165                 170                 175     


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
            180                 185                 190         


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
        195                 200                 205             


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
    210                 215                 220                 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
225                 230                 235                 240 


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
            260                 265                 270         


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
        275                 280                 285             


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
                325                 330                 335     


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
            340                 345                 350         


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
        355                 360                 365             


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
    370                 375                 380                 


Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
385                 390                 395                 400 


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
                405                 410                 415     


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
            420                 425                 430         


Lys 
    


<210>  11
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  misc_feature
<223>  Ab-1 light variable (with signal)

<400>  11
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgctc aagttctgac ccagagtcca agcagtctct ccgccagcgt aggcgatcgt      120

gtgactatta cctgtcaatc tagtcagagc gtgtatgata acaattggct ggcgtggtac      180

cagcaaaaac cgggcaaagc cccgaagctg ctcatctatg acgcgtccga tctggctagc      240

ggtgtgccaa gccgtttcag tggcagtggc agcggtactg actttaccct cacaatttcg      300

tctctccagc cggaagattt cgccacttac tattgtcaag gtgcttacaa cgatgtgatt      360

tatgccttcg gtcagggcac taaagtagaa                                       390


<210>  12
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  MISC_FEATURE
<223>  Ab-1 light variable (with signal)

<400>  12

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Ala Tyr Asn Asp Val Ile Tyr Ala Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg 
    130             


<210>  13
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  misc_feature
<223>  Ab-1 heavy variable (with signal)

<400>  13
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccactgtgag       60

gtgcagctgt tggagtctgg aggcgggctt gtccagcctg gagggagcct gcgtctctct      120

tgtgcagcaa gcggcttcag cttatcctct tactggatga attgggtgcg gcaggcacct      180

gggaagggcc tggagtgggt gggcaccatt gattccggag gccgtacaga ctacgcgtct      240

tgggcaaagg gccgtttcac catttcccgc gacaactcca aaaataccat gtacctccag      300

atgaactctc tccgcgcaga ggacacagca cgttattact gtgcacgcaa ctggaatctg      360

tggggtcaag gtactcttgt aacagtctcg agc                                   393


<210>  14
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  14

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Thr Ile Asp Ser Gly Gly Arg Thr Asp Tyr Ala Ser 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Arg Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asn Trp Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-B LCDR1

<400>  15

Ser Ala Ser Ser Ser Val Ser Phe Val Asp 
1               5                   10  


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-B LCDR2

<400>  16

Arg Thr Ser Asn Leu Gly Phe 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  17

Gln Gln Arg Ser Thr Tyr Pro Pro Thr 
1               5                   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-B HCDR1

<400>  18

Thr Ser Gly Met Gly Val Gly 
1               5           


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-B HCDR2

<400>  19

His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Val Leu Lys Ser 
1               5                   10                  15      


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-B HCDR3

<400>  20

Glu Asp Phe Asp Tyr Asp Glu Glu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  21
<211>  642
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-B light chain (no signal)

<400>  21
caaattgttc tcacccagtc tccaacaatc gtgtctgcat ctccagggga gaaggtcacc       60

ctaatctgca gtgccagttc aagtgtaagt ttcgtggact ggttccagca gaagccaggc      120

acttctccca aacgctggat ttacagaaca tccaacctgg gttttggagt ccctgctcgc      180

ttcagtggcg gtggatctgg gacctctcac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtacttacc cacccacgtt cggtgctggg      300

accaagctgg aactgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      360

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      420

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      480

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      540

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      600

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                         642


<210>  22
<211>  213
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-B light chain (no signal)

<400>  22

Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Val Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ile Cys Ser Ala Ser Ser Ser Val Ser Phe Val 
            20                  25                  30          


Asp Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Gly Phe Gly Val Pro Ala Arg Phe Ser Gly Gly 
    50                  55                  60                  


Gly Ser Gly Thr Ser His Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Thr Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  23
<211>  1350
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-B heavy chain (no signal)

<400>  23
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt      120

cacccatcag ggaagaatct ggagtggctg gcacacattt ggtgggatga tgtcaagcgc      180

tataacccag tcctgaagag ccgactgact atctccaagg atacctccaa cagccaggta      240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catactactg tgctcgaata      300

gaggactttg attacgacga ggagtattat gctatggact actggggtca aggaacctca      360

gtcatcgtct cctcagccaa aacgacaccc ccatctgtct atccactggc ccctggatct      420

gctgcccaaa ctaactccat ggtgaccctg ggatgcctgg tcaagggcta tttccctgag      480

ccagtgacag tgacctggaa ctctggatcc ctgtccagcg gtgtgcacac cttcccagct      540

gtcctgcagt ctgacctcta cactctgagc agctcagtga ctgtcccctc cagcacctgg      600

cccagcgaga ccgtcacctg caacgttgcc cacccggcca gcagcaccaa ggtggacaag      660

aaaattgtgc ccagggattg tggttgtaag ccttgcatat gtacagtccc agaagtatca      720

tctgtcttca tcttcccccc aaagcccaag gatgtgctca ccattactct gactcctaag      780

gtcacgtgtg ttgtggtaga catcagcaag gatgatcccg aggtccagtt cagctggttt      840

gtagatgatg tggaggtgca cacagctcag acgcaacccc gggaggagca gttcaacagc      900

actttccgct cagtcagtga acttcccatc atgcaccagg actggctcaa tggcaaggag      960

ttcaaatgca gggtcaacag tgcagctttc cctgccccca tcgagaaaac catctccaaa     1020

accaaaggca gaccgaaggc tccacaggtg tacaccattc cacctcccaa ggagcagatg     1080

gccaaggata aagtcagtct gacctgcatg ataacagact tcttccctga agacattact     1140

gtggagtggc agtggaatgg gcagccagcg gagaactaca agaacactca gcccatcatg     1200

gacacagatg gctcttactt cgtctacagc aagctcaatg tgcagaagag caactgggag     1260

gcaggaaata ctttcacctg ctctgtgtta catgagggcc tgcacaacca ccatactgag     1320

aagagcctct cccactctcc tggtaaatga                                      1350


<210>  24
<211>  449
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-B heavy chain (no signal)

<400>  24

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg His Pro Ser Gly Lys Asn Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Glu Asp Phe Asp Tyr Asp Glu Glu Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Ile Val Ser Ser Ala Lys Thr 
        115                 120                 125             


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
    130                 135                 140                 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            180                 185                 190         


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
    210                 215                 220                 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
                245                 250                 255     


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
    290                 295                 300                 


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
            340                 345                 350         


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
        355                 360                 365             


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
    370                 375                 380                 


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
385                 390                 395                 400 


Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
                405                 410                 415     


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-C LCDR1

<400>  25

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-C LCDR2

<400>  26

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-C LCDR3

<400>  27

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-C HCDR1

<400>  28

Asp Cys Tyr Met Asn 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-C HCDR2

<400>  29

Asp Ile Asn Pro Phe Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-C HCDR3

<400>  30

Ser His Tyr Tyr Phe Asp Gly Arg Val Pro Trp Asp Ala Met Asp Tyr 
1               5                   10                  15      


<210>  31
<211>  657
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-C light chain (no signal)

<400>  31
gacattgtgc tgacccaatc tccagcttct ttgactgtgt ctctaggcct gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcaatggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgtaacctat tactgtcaac aaagtaatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc      360

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      420

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      480

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      540

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      600

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag         657


<210>  32
<211>  218
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-C light chain (no signal)

<400>  32

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Leu Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Asn Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Val Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  33
<211>  1350
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-C heavy chain (no signal)

<400>  33
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctgggacttc agtgaagatg       60

tcctgtaagg cttctggata cacattcact gactgctaca tgaactgggt gaagcagagc      120

catgggaaga gccttgaatg gattggagat attaatcctt tcaacggtgg tactacctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca acagcctgac atctgacgac tctgcagtct attactgtgc aagatcccat      300

tattacttcg atggtagagt cccttgggat gctatggact actggggtca aggaacctca      360

gtcaccgtct cctcagccaa aacgacaccc ccatctgtct atccactggc ccctggatct      420

gctgcccaaa ctaactccat ggtgaccctg ggatgcctgg tcaagggcta tttccctgag      480

ccagtgacag tgacctggaa ctctggatcc ctgtccagcg gtgtgcacac cttcccagct      540

gtcctgcagt ctgacctcta cactctgagc agctcagtga ctgtcccctc cagcacctgg      600

cccagcgaga ccgtcacctg caacgttgcc cacccggcca gcagcaccaa ggtggacaag      660

aaaattgtgc ccagggattg tggttgtaag ccttgcatat gtacagtccc agaagtatca      720

tctgtcttca tcttcccccc aaagcccaag gatgtgctca ccattactct gactcctaag      780

gtcacgtgtg ttgtggtaga catcagcaag gatgatcccg aggtccagtt cagctggttt      840

gtagatgatg tggaggtgca cacagctcag acgcaacccc gggaggagca gttcaacagc      900

actttccgct cagtcagtga acttcccatc atgcaccagg actggctcaa tggcaaggag      960

ttcaaatgca gggtcaacag tgcagctttc cctgccccca tcgagaaaac catctccaaa     1020

accaaaggca gaccgaaggc tccacaggtg tacaccattc cacctcccaa ggagcagatg     1080

gccaaggata aagtcagtct gacctgcatg ataacagact tcttccctga agacattact     1140

gtggagtggc agtggaatgg gcagccagcg gagaactaca agaacactca gcccatcatg     1200

gacacagatg gctcttactt catctacagc aagctcaatg tgcagaagag caactgggag     1260

gcaggaaata ctttcacctg ctctgtgtta catgagggcc tgcacaacca ccatactgag     1320

aagagcctct cccactctcc tggtaaatga                                      1350


<210>  34
<211>  449
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-C heavy chain (no signal)

<400>  34

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Cys 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Phe Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Tyr Tyr Phe Asp Gly Arg Val Pro Trp Asp Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
        115                 120                 125             


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
    130                 135                 140                 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            180                 185                 190         


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
    210                 215                 220                 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
                245                 250                 255     


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
    290                 295                 300                 


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
            340                 345                 350         


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
        355                 360                 365             


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
    370                 375                 380                 


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
385                 390                 395                 400 


Asp Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys 
                405                 410                 415     


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-D LCDR1

<400>  35

Gln Ala Ser Gln Gly Thr Ser Ile Asn Leu Asn 
1               5                   10      


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-D LCDR2

<400>  36

Gly Ser Ser Asn Leu Glu Asp 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-D LCDR3

<400>  37

Leu Gln His Ser Tyr Leu Pro Tyr Thr 
1               5                   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-D HCDR1

<400>  38

Asp His Tyr Met Ser 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-D HCDR2

<400>  39

Asp Ile Asn Pro Tyr Ser Gly Glu Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-D HCDR3

<400>  40

Asp Asp Tyr Asp Ala Ser Pro Phe Ala Tyr 
1               5                   10  


<210>  41
<211>  645
<212>  DNA
<213>  Mus musculus

<400>  41
gatgtccaga tgattcagtc tccatcctcc ctgtctgcat ctttgggaga catagtcacc       60

atgacttgcc aggcaagtca gggcactagc attaatttaa actggtttca gcaaaaacca      120

gggaaggctc ctaagctcct gatctatggt tcaagcaact tggaagatgg ggtcccatca      180

aggttcagtg gcagtagata tgggacagat ttcactctca ccatcagcag cctggaggat      240

gaagatctgg caacttattt ctgtctacaa catagttatc tcccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  42
<211>  214
<212>  PRT
<213>  Mus musculus

<400>  42

Asp Val Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Ile Val Thr Met Thr Cys Gln Ala Ser Gln Gly Thr Ser Ile Asn 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Ser Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Asp 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Phe Cys Leu Gln His Ser Tyr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  43
<211>  1332
<212>  DNA
<213>  Mus musculus

<400>  43
gaggtccagc tgcaacagtc tggacctgaa ctggtgacgc ctggggcttc agtgaagata       60

tcttgtaagg cttctggata cacattcact gaccactaca tgagctgggt gaagcagagt      120

catggaaaaa gccttgagtg gattggagat attaatccct attctggtga aactacctac      180

aaccagaagt tcaagggcac ggccacattg actgtagaca agtcttccag tatagcctac      240

atggagatcc gcggcctgac atctgaggac tctgcagtct attactgtgc aagagatgat      300

tacgacgcct ctccgtttgc ttactggggc caagggactc tggtcactgt ctctgcagcc      360

aaaacgacac ccccatctgt ctatccactg gcccctggat ctgctgccca aactaactcc      420

atggtgaccc tgggatgcct ggtcaagggc tatttccctg agccagtgac agtgacctgg      480

aactctggat ccctgtccag cggtgtgcac accttcccag ctgtcctgca gtctgacctc      540

tacactctga gcagctcagt gactgtcccc tccagcacct ggcccagcga gaccgtcacc      600

tgcaacgttg cccacccggc cagcagcacc aaggtggaca agaaaattgt gcccagggat      660

tgtggttgta agccttgcat atgtacagtc ccagaagtat catctgtctt catcttcccc      720

ccaaagccca aggatgtgct caccattact ctgactccta aggtcacgtg tgttgtggta      780

gacatcagca aggatgatcc cgaggtccag ttcagctggt ttgtagatga tgtggaggtg      840

cacacagctc agacgcaacc ccgggaggag cagttcaaca gcactttccg ctcagtcagt      900

gaacttccca tcatgcacca ggactggctc aatggcaagg agttcaaatg cagggtcaac      960

agtccagctt tccctgcccc catcgagaaa accatctcca aaaccaaagg cagaccgaag     1020

gctccacagg tgtacaccat tccacctccc aaggagcaga tggccaagga taaagtcagt     1080

ctgacctgca tgataacaga cttcttccct gaagacatta ctgtggagtg gcagtggaat     1140

gggcagccag cggagaacta caagaacact cagcccatca tggacacaga tggctcttac     1200

ttcatctaca gcaagctcaa tgtgcagaag agcaactggg aggcaggaaa tactttcacc     1260

tgctctgtgt tacatgaggg cctgcacaac caccatactg agaagagcct ctcccactct     1320

cctggtaaat ga                                                         1332


<210>  44
<211>  443
<212>  PRT
<213>  Mus musculus

<400>  44

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Ser Gly Glu Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Thr Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Tyr Asp Ala Ser Pro Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
    210                 215                 220                 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
            260                 265                 270         


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
    290                 295                 300                 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
305                 310                 315                 320 


Ser Pro Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
            340                 345                 350         


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
        355                 360                 365             


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
    370                 375                 380                 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
                405                 410                 415     


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440             


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-2 LCDR1

<400>  45

Arg Ala Ser Ser Ser Val Tyr Tyr Tyr Met His 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-2 LCDR2

<400>  46

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 LCDR3

<400>  47

Gln Gln Trp Ser Ser Asp Pro Leu Thr 
1               5                   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-2 HCDR1

<400>  48

Asp Tyr Phe Ile His 
1               5   


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-2 HCDR2

<400>  49

Arg Leu Asp Pro Glu Asp Gly Glu Ser Asp Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-2 HCDR3

<400>  50

Glu Asp Tyr Asp Gly Thr Tyr Thr Phe Phe Pro Tyr 
1               5                   10          


<210>  51
<211>  642
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-2 light chain (no signal)

<400>  51
caaattgttc tctcccagtc tccagcaatc ctgtctacat ctccagggga gaaggtcaca       60

atgacttgca gggccagctc aagtgtatat tacatgcact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcaccagagt ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtgacc cactcacgtt cggtgctggg      300

accaagctgg agctgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      360

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      420

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      480

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      540

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      600

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                         642


<210>  52
<211>  213
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-2 light chain (no signal)

<400>  52

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Tyr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  53
<211>  1338
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-2 heavy chain (no signal)

<400>  53
gaggttcagg tgcagcagtc tgggccagaa cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactacttta tacactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg cttgatcctg aggatggtga aagtgattat      180

gccccgaagt tccaggacaa ggccattatg acagcagaca catcatccaa cacagcctat      240

cttcagctca gaagcctgac atctgaggac actgccatct attattgtga gagagaggac      300

tacgatggta cctacacctt ttttccttac tggggccaag ggactctggt cactgtctct      360

gcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact      420

aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg      480

acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct      540

gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc      600

gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc      660

agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc      720

ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt      780

gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg      840

gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca      900

gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg      960

gtcaacagtg cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga     1020

ccgaaggctc cacaggtgta caccattcca cctcccaagg agcagatggc caaggataaa     1080

gtcagtctga cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag     1140

tggaatgggc agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc     1200

tcttacttca tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact     1260

ttcacctgct ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc     1320

cactctcctg gtaaatga                                                   1338


<210>  54
<211>  445
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-2 heavy chain (no signal)

<400>  54

Glu Val Gln Val Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Leu Asp Pro Glu Asp Gly Glu Ser Asp Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Ile Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Asp Tyr Asp Gly Thr Tyr Thr Phe Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 and Ab-15 LCDR1

<400>  55

Ser Val Ser Ser Thr Ile Ser Ser Asn His Leu His 
1               5                   10          


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 and Ab-15 LCDR2

<400>  56

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 and Ab-15 LCDR3

<400>  57

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 and Ab-15 HCDR1

<400>  58

Asp Phe Tyr Leu His 
1               5   


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 and Ab-15 HCDR2

<400>  59

Arg Ile Asp Pro Glu Asn Gly Asp Thr Leu Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-3 and Ab-15 HCDR3

<400>  60

Glu Ala Asp Tyr Phe His Asp Gly Thr Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  61
<211>  648
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-3 light chain

<400>  61
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccggggga gaaggtcacc       60

atcacctgca gtgtcagttc aactataagt tccaaccact tgcactggtt ccagcagaag      120

tcagacacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaggatg ctgccactta ttactgtcaa cagtggagta gttacccact cacgttcggc      300

gctgggacca agctggagct gagacgggct gatgctgcac caactgtatc catcttccca      360

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      420

taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      480

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      540

acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      600

acatcaactt cacccattgt caagagcttc aacaggaatg agtgttag                   648


<210>  62
<211>  215
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-3 light chain (no signal)

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Thr Ile Ser Ser Asn 
            20                  25                  30          


His Leu His Trp Phe Gln Gln Lys Ser Asp Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  63
<211>  1350
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-3 heavy chain

<400>  63
gaggttcagc tgcagcagtc tggggctgaa cttgtgaggc caggggcctt agtcaagttg       60

tcctgcacag cttctgactt caacattaaa gacttctatc tacactggat gaggcagcgg      120

cctgaacagg gcctggactg gattggaagg attgatcctg agaatggtga tactttatat      180

gacccgaagt tccaggacaa ggccactctt acaacagaca catcctccaa cacagcctac      240

ctgcagctca gcggcctgac atctgagacc actgccgtct attactgttc tagagaggcg      300

gattatttcc acgatggtac ctcctactgg tacttcgatg tctggggcgc agggaccaca      360

atcaccgtct cctcagccaa aacgacaccc ccatctgtct atccactggc ccctggatct      420

gctgcccaaa ctaactccat ggtgaccctg ggatgcctgg tcaagggcta tttccctgag      480

ccagtgacag tgacctggaa ctctggatcc ctgtccagcg gtgtgcacac cttcccagct      540

gtcctgcagt ctgacctcta cactctgagc agctcagtga ctgtcccctc cagcacctgg      600

cccagcgaga ccgtcacctg caacgttgcc cacccggcca gcagcaccaa ggtggacaag      660

aaaattgtgc ccagggattg tggttgtaag ccttgcatat gtacagtccc agaagtatca      720

tctgtcttca tcttcccccc aaagcccaag gatgtgctca ccattactct gactcctaag      780

gtcacgtgtg ttgtggtaga catcagcaag gatgatcccg aggtccagtt cagctggttt      840

gtagatgatg tggaggtgca cacagctcag acgcaacccc gggaggagca gttcaacagc      900

actttccgct cagtcagtga acttcccatc atgcaccagg actggctcaa tggcaaggag      960

ttcaaatgca gggtcaacag tgcagctttc cctgccccca tcgagaaaac catctccaaa     1020

accaaaggca gaccgaaggc tccacaggtg tacaccattc cacctcccaa ggagcagatg     1080

gccaaggata aagtcagtct gacctgcatg ataacagact tcttccctga agacattact     1140

gtggagtggc agtggaatgg gcagccagcg gagaactaca agaacactca gcccatcatg     1200

gacacagatg gctcttactt catctacagc aagctcaatg tgcagaagag caactgggag     1260

gcaggaaata ctttcacctg ctctgtgtta catgagggcc tgcacaacca ccatactgag     1320

aagagcctct cccactctcc tggtaaatga                                      1350


<210>  64
<211>  449
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-3 heavy chain (no signal)

<400>  64

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Thr Ala Ser Asp Phe Asn Ile Lys Asp Phe 
            20                  25                  30          


Tyr Leu His Trp Met Arg Gln Arg Pro Glu Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Asp Thr Leu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Leu Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Thr Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Ala Asp Tyr Phe His Asp Gly Thr Ser Tyr Trp Tyr Phe 
            100                 105                 110         


Asp Val Trp Gly Ala Gly Thr Thr Ile Thr Val Ser Ser Ala Lys Thr 
        115                 120                 125             


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
    130                 135                 140                 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            180                 185                 190         


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
    210                 215                 220                 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
                245                 250                 255     


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
    290                 295                 300                 


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
            340                 345                 350         


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
        355                 360                 365             


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
    370                 375                 380                 


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
385                 390                 395                 400 


Asp Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys 
                405                 410                 415     


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  65
<211>  324
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-15 light variable

<400>  65
gacatccaga tgacccagtc tccatcctcc ctctcagcat ccgtaggcga tagagttaca       60

ataacatgca gcgtatcatc aactatatca tcaaatcatc ttcattggtt ccaacagaaa      120

cccggcaaag cacctaaatc acttatatac ggcacatcaa atctcgcatc aggcgttcct      180

tcaagatttt caggctctgg ctcaggcacc gactttactc ttacaatatc ctccctccaa      240

cccgaagact tcgcaaccta ttactgtcaa caatggtcct catatccact cacatttggc      300

ggcggcacaa aagtagaaat taaa                                             324


<210>  66
<211>  108
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-15 light variable

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Thr Ile Ser Ser Asn 
            20                  25                  30          


His Leu His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  67
<211>  375
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-15 heavy variable

<400>  67
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgactt caacattaaa gacttctatc tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gattggaagg attgatcctg agaatggtga tactttatat      180

gacccgaagt tccaggacaa ggtcaccatg accacagaca cgtccaccag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagaggcg      300

gattatttcc acgatggtac ctcctactgg tacttcgatg tctggggccg tggcaccctg      360

gtcaccgtct ctagt                                                       375


<210>  68
<211>  125
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-15 heavy variable

<400>  68

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Phe Asn Ile Lys Asp Phe 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Asp Thr Leu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Asp Tyr Phe His Asp Gly Thr Ser Tyr Trp Tyr Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  69
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  misc_feature
<223>  Ab-15 light chain

<400>  69
gacatccaga tgacccagtc tccatcctcc ctctcagcat ccgtaggcga tagagttaca       60

ataacatgca gcgtatcatc aactatatca tcaaatcatc ttcattggtt ccaacagaaa      120

cccggcaaag cacctaaatc acttatatac ggcacatcaa atctcgcatc aggcgttcct      180

tcaagatttt caggctctgg ctcaggcacc gactttactc ttacaatatc ctccctccaa      240

cccgaagact tcgcaaccta ttactgtcaa caatggtcct catatccact cacatttggc      300

ggcggcacaa aagtagaaat taaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  70
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  MISC_FEATURE
<223>  Ab-15 light chain

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Thr Ile Ser Ser Asn 
            20                  25                  30          


His Leu His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  71
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  misc_feature
<223>  Ab-15 heavy chain

<400>  71
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgactt caacattaaa gacttctatc tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gattggaagg attgatcctg agaatggtga tactttatat      180

gacccgaagt tccaggacaa ggtcaccatg accacagaca cgtccaccag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagaggcg      300

gattatttcc acgatggtac ctcctactgg tacttcgatg tctggggccg tggcaccctg      360

gtcaccgtct ctagtgcctc caccaagggc ccatcggtct tccccctggc gccctgctcc      420

aggagcacct ccgagagcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgct ctgaccagcg gcgtgcacac cttcccagct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcaac      600

ttcggcaccc agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac      660

aagacagttg agcgcaaatg ttgtgtcgag tgcccaccgt gcccagcacc acctgtggca      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca cgtgcgtggt ggtggacgtg agccacgaag accccgaggt ccagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccacggga ggagcagttc      900

aacagcacgt tccgtgtggt cagcgtcctc accgttgtgc accaggactg gctgaacggc      960

aaggagtaca agtgcaaggt ctccaacaaa ggcctcccag cccccatcga gaaaaccatc     1020

tccaaaacca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacacctccc     1200

atgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  72
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  MISC_FEATURE
<223>  Ab-15 heavy chain

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Phe Asn Ile Lys Asp Phe 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Asp Thr Leu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Asp Tyr Phe His Asp Gly Thr Ser Tyr Trp Tyr Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-4 and Ab-5 LCDR1

<400>  73

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-4 and Ab-5 LCDR2

<400>  74

Tyr Thr Ser Arg Leu Leu Ser 
1               5           


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-4 and Ab-5 LCDR3

<400>  75

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-4 and Ab-5 HCDR1

<400>  76

Asp Tyr Asn Met His 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-4 and Ab-5 HCDR2

<400>  77

Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  78

Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  79
<211>  645
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-4 light chain

<400>  79
gatatccaga tgacacagat tacatcctcc ctgtctgcct ctctgggaga cagggtctcc       60

atcagttgca gggcaagtca agacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactt ttaaactcct tatcttctac acatcaagat tactctcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccatttacaa cctggagcaa      240

gaagattttg ccacttactt ttgccaacag ggagatacgc ttccgtacac tttcggaggg      300

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  80
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-4 light chain

<400>  80

Asp Ile Gln Met Thr Gln Ile Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Tyr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  81
<211>  1344
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-4 heavy chain

<400>  81
gaggtccaac tgcaacagtc tggacctgaa ctaatgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata tacattcact gactacaaca tgcactgggt gaagcagaac      120

caaggaaaga ccctagagtg gataggagaa attaatccta acagtggtgg tgctggctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccac cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagattgggc      300

tacgatgata tctacgacga ctggtacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      420

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      480

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      540

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      600

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      660

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      720

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      780

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      840

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      900

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa      960

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1020

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1080

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1140

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1200

gatggctctt acttcatcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1260

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1320

ctctcccact ctcctggtaa atga                                            1344


<210>  82
<211>  447
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-4 heavy chain

<400>  82

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Asn Gln Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
    130                 135                 140                 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215                 220                 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  83
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-5 light variable

<400>  83
gacatccaga tgacccagtc tccatcctcc ctctccgcat ccgtaggcga ccgcgtaacc       60

ataacatgta gagcatctca agatatttcc aactatttga attggtacca acaaaaaccc      120

ggcaaagcac ctaaactcct catttactat acatcaagac tcctctccgg cgttccatca      180

cgattctcag gctccggctc cggcacagat ttcacactca ctatttcctc cctccaacca      240

gaagattttg caacctatta ctgtcaacaa ggcgatacac tcccatacac attcggcggc      300

ggcacaaaag ttgaaattaa a                                                321


<210>  84
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-5 light variable

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  85
<211>  369
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-5 heavy variable

<400>  85
gaggtgcagc tggtgcagag cggcgccgag gtaaaaaaac caggagcaag cgttaaagtt       60

tcttgtaaag caagcggata tacatttaca gattacaaca tgcattgggt aagacaagcg      120

ccaggacaag gattggaatg gatgggcgaa attaacccta atagtggagg agcaggctac      180

aatcaaaaat tcaaagggag agttacaatg acaacagaca caagcacttc aacagcatat      240

atggaactgc gatcacttag aagcgacgat acagctgtat actattgcgc acgacttggg      300

tatgatgata tatatgatga ctggtatttc gatgtttggg gccagggaac aacagttacc      360

gtctctagt                                                              369


<210>  86
<211>  123
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-5 heavy variable

<400>  86

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  87
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  misc_feature
<223>  Ab-5 light chain

<400>  87
gacatccaga tgacccagtc tccatcctcc ctctccgcat ccgtaggcga ccgcgtaacc       60

ataacatgta gagcatctca agatatttcc aactatttga attggtacca acaaaaaccc      120

ggcaaagcac ctaaactcct catttactat acatcaagac tcctctccgg cgttccatca      180

cgattctcag gctccggctc cggcacagat ttcacactca ctatttcctc cctccaacca      240

gaagattttg caacctatta ctgtcaacaa ggcgatacac tcccatacac attcggcggc      300

ggcacaaaag ttgaaattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  88
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  MISC_FEATURE
<223>  Ab-5 light chain

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  89
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  misc_feature
<223>  Ab-5 heavy chain

<400>  89
gaggtgcagc tggtgcagag cggcgccgag gtaaaaaaac caggagcaag cgttaaagtt       60

tcttgtaaag caagcggata tacatttaca gattacaaca tgcattgggt aagacaagcg      120

ccaggacaag gattggaatg gatgggcgaa attaacccta atagtggagg agcaggctac      180

aatcaaaaat tcaaagggag agttacaatg acaacagaca caagcacttc aacagcatat      240

atggaactgc gatcacttag aagcgacgat acagctgtat actattgcgc acgacttggg      300

tatgatgata tatatgatga ctggtatttc gatgtttggg gccagggaac aacagttacc      360

gtctctagtg cctccaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc      420

acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag caacttcggc      600

acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca      660

gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag caccacctgt ggcaggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc      900

acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa     1020

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  90
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  MISC_FEATURE
<223>  Ab-5 heavy chain

<400>  90

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
    210                 215                 220                 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-6 LCDR1

<400>  91

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-6 LCDR2

<400>  92

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-6 LCDR3

<400>  93

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-6 HCDR1

<400>  94

Asp Tyr Asn Met His 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-6 HCDR2

<400>  95

Glu Ile Asn Pro Asn Ser Gly Gly Ser Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-6 HCDR3

<400>  96

Leu Val Tyr Asp Gly Ser Tyr Glu Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  97
<211>  645
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-6 light chain

<400>  97
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtttca gcagaaacca      120

gatggaactc ttaaactcct gatcttctac acatcaagat tacactcagg agttccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtgatacgc ttccgtacac gttcgggggg      300

gggaccaagc tggaaataag acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  98
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-6 light chain

<400>  98

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Leu Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  99
<211>  1344
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-6 heavy chain

<400>  99
gaggtccagc tgcaacagtc tggacctgaa ctaatgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaaacagaac      120

caaggaaaga gcctagagtg gataggagaa attaatccta acagtggtgg tagtggctac      180

aaccaaaagt tcaaaggcaa ggccacattg actgtagaca agtcttccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagattggtc      300

tacgatggca gctacgagga ctggtacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      420

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      480

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      540

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      600

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      660

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      720

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      780

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      840

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      900

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa      960

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1020

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1080

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1140

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1200

gatggctctt acttcatcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1260

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1320

ctctcccact ctcctggtaa atga                                            1344


<210>  100
<211>  447
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-6 heavy chain

<400>  100

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Asn Gln Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ser Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Tyr Asp Gly Ser Tyr Glu Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
    130                 135                 140                 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215                 220                 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-7 LCDR1

<400>  101

Arg Ala Ser Gln Val Ile Thr Asn Tyr Leu Tyr 
1               5                   10      


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-7 LCDR2

<400>  102

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-7 LCDR3

<400>  103

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-7 HCDR1

<400>  104

Asp Tyr Asn Met His 
1               5   


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-7 HCDR2

<400>  105

Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Gln Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-7 HCDR3

<400>  106

Leu Gly Tyr Val Gly Asn Tyr Glu Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  107
<211>  642
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-7 light chain

<400>  107
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atctgttgca gggcaagtca ggtcattacc aattatttat actggtatca gcagaaacca      120

gatggaactt ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaacag      240

gaagatattg ccacttactt ttgccaacag ggtgatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  108
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-7 light chain

<400>  108

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Cys Arg Ala Ser Gln Val Ile Thr Asn Tyr 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  109
<211>  1341
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-7 heavy chain

<400>  109
gaggtccagc tgcaacagtc tggacctgaa ctaatgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactggat gaagcagaac      120

caaggaaaga gcctagaatg gataggagaa attaatccta acagtggtgg tgctggctac      180

aaccagcagt tcaaaggcaa ggccacattg actgtagaca agtcctccag gacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagattgggc      300

tacgttggta attacgagga ctggtacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      420

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      480

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      540

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      600

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      660

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      720

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      780

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      840

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      900

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa      960

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1020

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1080

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1140

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1200

gatggctctt acttcatcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1260

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1320

ctctcccact ctcctggtaa a                                               1341


<210>  110
<211>  447
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-7 heavy chain

<400>  110

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Met Lys Gln Asn Gln Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Val Gly Asn Tyr Glu Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
    130                 135                 140                 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215                 220                 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-8 LCDR1

<400>  111

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-8 LCDR2

<400>  112

Tyr Thr Ser Arg Leu Leu Ser 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-8 LCDR3

<400>  113

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-8 HCDR1

<400>  114

Asp Tyr Asn Met His 
1               5   


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-8 HCDR2

<400>  115

Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-8 HCDR3

<400>  116

Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  117
<211>  645
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-8 light chain

<400>  117
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagggtctcc       60

atcagttgca gggcaagtca agacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactt ttaaactcct tatcttctac acatcaagat tactctcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccatttacaa cctggagcaa      240

gaagattttg ccacttactt ttgccaacag ggagatacgc ttccgtacac tttcggaggg      300

gggaccaaac tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  118
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-8 light chain

<400>  118

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Tyr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  119
<211>  1344
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab-8 heavy chain

<400>  119
gaggtccaac tgcaacagtc tggacctgaa ctaatgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata tacattcact gactacaaca tgcactgggt gaagcagaac      120

caaggaaaga ccctagactg gataggagaa attaatccta acagtggtgg tgctggctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccac cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagattgggc      300

tacgatgata tctacgacga ctggtacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      420

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      480

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      540

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      600

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      660

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      720

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      780

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      840

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      900

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa      960

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1020

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1080

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1140

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1200

gatggctctt acttcatcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1260

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1320

ctctcccact ctcctggtaa atga                                            1344


<210>  120
<211>  447
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab-8 heavy chain

<400>  120

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Asn Gln Gly Lys Thr Leu Asp Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
    130                 135                 140                 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215                 220                 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-9 LCDR1

<400>  121

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-9 LCDR2

<400>  122

Tyr Thr Ser Arg Leu Phe Ser 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-9 LCDR3

<400>  123

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-9 HCDR1

<400>  124

Asp Tyr Asn Met His 
1               5   


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-9 HCDR2

<400>  125

Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-9 HCDR3

<400>  126

Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  127
<211>  642
<212>  DNA
<213>  Mus musculus

<400>  127
gatatccaga tgacacagat tacatcctcc ctgtctgcct ctctgggaga cagggtctcc       60

atcagttgca gggcaagtca agacattagc aattatttaa attggtatca gcagaaacca      120

gatggaactt ttaaactcct tatcttctac acatcaagat tattttcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccatttacaa cctggagcaa      240

gaagattttg ccacttactt ttgccaacag ggagatacgc ttccgtacac tttcggaggg      300

gggaccaagg tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  128
<211>  214
<212>  PRT
<213>  Mus musculus

<400>  128

Asp Ile Gln Met Thr Gln Ile Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Tyr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  129
<211>  1350
<212>  DNA
<213>  Mus musculus

<400>  129
gaggtccaac tgcaacagtc tggacctgaa ctaatgaagc ctgggacttc agtgaagatg       60

tcctgcaagg cttctggata tacattcact gactacaaca tgcactgggt gaagcagacc      120

caaggaaaga ccctagagtg gataggagaa attaatccta acagtggtgg tgctggctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccac cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aaaattgggc      300

tacgatgata tctacgacga ctggtatttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag ccaaaacaac agccccatcg gtctatccac tggcccctgt gtgtggagat      420

acaactggct cctcggtgac tctaggatgc ctggtcaagg gttatttccc tgagccagtg      480

accttgacct ggaactctgg atccctgtcc agtgatgtgc acaccttccc agctctcctg      540

cagtctggcc tctacaccct cagcagctca gtgactgtaa ccacctggcc cagccagacc      600

atcacctgca atgtggccca cccggcaagc agcaccaaag tggacaagaa aattgagccc      660

agagggtccc caacacataa accctgtcct ccatgcccag ctcctaacct cttgggtgga      720

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      780

atggtcacgt gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca tgtcagctgg      840

ttcgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac      900

agtactatcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag      960

gagttcaaat gcaaggtcaa caacaaagcc ctcccagcgc ccatcgagag aaccatctca     1020

aaacccaaag ggccagtaag agctccacag gtatatgtct tgcctccacc agaagaagag     1080

atgactaaga aacaggtcac tctgacctgc atgatcacag acttcatgcc tgaagacatt     1140

tacgtggagt ggaccaacaa cgggcaaaca gagctaaact acaagaacac tgaaccagtc     1200

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg     1260

gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg     1320

actaagagct tctcccggac tccgggtaaa                                      1350


<210>  130
<211>  450
<212>  PRT
<213>  Mus musculus

<400>  130

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Gln Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Ala 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
    130                 135                 140                 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Asp Val His Thr Phe 
                165                 170                 175     


Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Thr Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Ser Pro 
    210                 215                 220                 


Thr His Lys Pro Cys Pro Pro Cys Pro Ala Pro Asn Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
                245                 250                 255     


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
            260                 265                 270         


Asp Pro Asp Val His Val Ser Trp Phe Val Asn Asn Val Glu Val His 
        275                 280                 285             


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Pro Lys Gly Pro Val Arg Ala Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
        355                 360                 365             


Thr Cys Met Ile Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
    370                 375                 380                 


Thr Asn Asn Gly Gln Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
                405                 410                 415     


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
            420                 425                 430         


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-10 LCDR1

<400>  131

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-10 LCDR2

<400>  132

Tyr Thr Ser Arg Leu Leu Ser 
1               5           


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-10 LCDR3

<400>  133

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-10 HCDR1

<400>  134

Asp Tyr Asn Met His 
1               5   


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-10 HCDR2

<400>  135

Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-10 HCDR3

<400>  136

Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  137
<211>  645
<212>  DNA
<213>  Mus musculus

<400>  137
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagggtctcc       60

atcagttgca gggcaagtca agacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactt ttaaactcct tatcttctac acatcaagat tactctcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccatttacaa cctggagcaa      240

gaagattttg ccacttactt ttgccaacag ggagatacgc ttccgtacac tttcggaggg      300

gggaccaaac tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacta      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  138
<211>  214
<212>  PRT
<213>  Mus musculus

<400>  138

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Tyr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Leu Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  139
<211>  1344
<212>  DNA
<213>  Mus musculus

<400>  139
gaggtccaac tgcaacagtc tggacctgaa ctaatgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata tacattcact gactacaaca tgcactgggt gaagcagaac      120

caaggaaaga ccctagaatg gataggagaa attaatccta acagtggtgg tgctggctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccac cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagattgggc      300

tacgatgata tctacgacga ctggtacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      420

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      480

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      540

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      600

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      660

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      720

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      780

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      840

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      900

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa      960

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1020

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1080

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1140

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1200

gatggctctt acttcatcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1260

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1320

ctctcccact ctcctggtaa atga                                            1344


<210>  140
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  140

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Asn Gln Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
    130                 135                 140                 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215                 220                 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-11 and Ab-16 LCDR1

<400>  141

Arg Ala Ser Ser Ser Ile Ser Tyr Ile His 
1               5                   10  


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-11 and Ab-16 LCDR2

<400>  142

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-11 and Ab-16 LCDR3

<400>  143

Gln Gln Trp Ser Ser Asp Pro Leu Thr 
1               5                   


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-11 and Ab-16 HCDR1

<400>  144

Asp Tyr Tyr Ile His 
1               5   


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-11 and Ab-16 HCDR2

<400>  145

Arg Val Asp Pro Asp Asn Gly Glu Thr Glu Phe Ala Pro Lys Phe Pro 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-11 and Ab-16 HCDR3

<400>  146

Glu Asp Tyr Asp Gly Thr Tyr Thr Trp Phe Pro Tyr 
1               5                   10          


<210>  147
<211>  642
<212>  DNA
<213>  Mus musculus

<400>  147
caaattgttc tctcccagtc tccagcattc ctgtctgtat ctccagggga taaggtcaca       60

atgacttgca gggccagctc aagtataagt tacatacact ggtttcagca gaagccagga      120

tcctccccca gatcctggat ttatgccaca tccaacctgg cttctggagt ccctggtcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgag      240

gatgctgcca cttattactg ccagcagtgg agtagtgacc cactcacgtt cggtgctggg      300

accaagctgg agctgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      360

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      420

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      480

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      540

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      600

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                         642


<210>  148
<211>  213
<212>  PRT
<213>  Mus musculus

<400>  148

Gln Ile Val Leu Ser Gln Ser Pro Ala Phe Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Arg Ser Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  149
<211>  1338
<212>  DNA
<213>  Mus musculus

<400>  149
gaagttcagc tgcaacagtc tggggcagac cttgtgcagc caggggcctc agtcaaggtg       60

tcctgcacag cttctggctt cgacattaag gactactata tacactggat gaaacagagg      120

cctgaccagg gcctggagtg gattggaagg gttgatcctg acaatggtga gactgaattt      180

gccccgaagt tcccgggcaa ggccactttt acaacagaca catcctccaa cacagcctac      240

ctacaactca gaggcctgac atctgaggac actgccatct attactgtgg gagagaagac      300

tacgatggta cctacacctg gtttccttat tggggccaag ggactctggt cactgtctct      360

gcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact      420

aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg      480

acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct      540

gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc      600

gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc      660

agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc      720

ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt      780

gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg      840

gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca      900

gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg      960

gtcaacagtg cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga     1020

ccgaaggctc cacaggtgta caccattcca cctcccaagg agcagatggc caaggataaa     1080

gtcagtctga cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag     1140

tggaatgggc agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc     1200

tcttacttca tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact     1260

ttcacctgct ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc     1320

cactctcctg gtaaatga                                                   1338


<210>  150
<211>  445
<212>  PRT
<213>  Mus musculus

<400>  150

Glu Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe Asp Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Met Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asp Pro Asp Asn Gly Glu Thr Glu Phe Ala Pro Lys Phe 
    50                  55                  60                  


Pro Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Arg Gly Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Glu Asp Tyr Asp Gly Thr Tyr Thr Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  151
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  151
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gggccagctc aagtataagt tacatacact ggtatcagca aaaaccaggg      120

aaagccccta agctcctgat ctatgccaca tccaacctgg cttctggggt cccatcaagg      180

ttcagcggca gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa      240

gattttgcaa cttattactg tcagcagtgg agtagtgacc cactcacgtt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  152
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  152

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  153
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  153
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt cgacattaag gactactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatcggaagg gttgatcctg acaatggtga gactgaattt      180

gccccgaagt tcccgggcaa ggtcaccatg accacagaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagaagac      300

tacgatggta cctacacctg gtttccttat tggggccaag ggactctggt caccgtctct      360

agt                                                                    363


<210>  154
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  154

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asp Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asp Pro Asp Asn Gly Glu Thr Glu Phe Ala Pro Lys Phe 
    50                  55                  60                  


Pro Gly Lys Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Thr Tyr Thr Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  155
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  155
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gggccagctc aagtataagt tacatacact ggtatcagca aaaaccaggg      120

aaagccccta agctcctgat ctatgccaca tccaacctgg cttctggggt cccatcaagg      180

ttcagcggca gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa      240

gattttgcaa cttattactg tcagcagtgg agtagtgacc cactcacgtt cggcggaggg      300

accaaggtgg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  156
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  156

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  157
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  157
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt cgacattaag gactactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatcggaagg gttgatcctg acaatggtga gactgaattt      180

gccccgaagt tcccgggcaa ggtcaccatg accacagaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagaagac      300

tacgatggta cctacacctg gtttccttat tggggccaag ggactctggt caccgtctct      360

agtgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  158
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  158

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asp Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asp Pro Asp Asn Gly Glu Thr Glu Phe Ala Pro Lys Phe 
    50                  55                  60                  


Pro Gly Lys Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Thr Tyr Thr Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-12 LCDR1

<400>  159

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-12 LCDR2

<400>  160

Tyr Thr Ser Thr Leu Gln Ser 
1               5           


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-12 LCDR3

<400>  161

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-12 HCDR1

<400>  162

Asp Tyr Asn Met His 
1               5   


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-12 HCDR2

<400>  163

Glu Ile Asn Pro Asn Ser Gly Gly Ser Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  164
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-12 HCDR3

<400>  164

Leu Gly Tyr Tyr Gly Asn Tyr Glu Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  165
<211>  645
<212>  DNA
<213>  Mus musculus

<400>  165
gatctccaga tgacacagac tacttcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaagctcct gatcttctac acatcaacat tacagtcagg agtcccatcg      180

aggttcagtg gcagtgggtc tggaacaaat tattctctca ccattaccaa cctggagcaa      240

gatgatgctg ccacttactt ttgccaacag ggtgatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  166
<211>  214
<212>  PRT
<213>  Mus musculus

<400>  166

Asp Leu Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asn Tyr Ser Leu Thr Ile Thr Asn Leu Glu Gln 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  167
<211>  1344
<212>  DNA
<213>  Mus musculus

<400>  167
gaggtccagt tgcaacagtc tggacctgaa ctaatgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactggat gaagcagaac      120

caaggaaaga gcctagagtg gataggagag attaatccta acagtggtgg ttctggttac      180

aaccagaagt tcaaaggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagattgggc      300

tactatggta actacgagga ctggtatttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctctg ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      420

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      480

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      540

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      600

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      660

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      720

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      780

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      840

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      900

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa      960

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1020

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1080

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1140

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1200

gatggctctt acttcatcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1260

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1320

ctctcccact ctcctggtaa atga                                            1344


<210>  168
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  168

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Met Lys Gln Asn Gln Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Gly Gly Ser Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Gly Asn Tyr Glu Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
    130                 135                 140                 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215                 220                 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  169
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-13 and Ab-14 LCDR1

<400>  169

Arg Ala Ser Ser Ser Val Thr Ser Ser Tyr Leu Asn 
1               5                   10          


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-13 and Ab-14 LCDR2

<400>  170

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-13 and Ab-14 LCDR3

<400>  171

Gln Gln Tyr Asp Phe Phe Pro Ser Thr 
1               5                   


<210>  172
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-13 and Ab-14 HCDR1

<400>  172

Asp Tyr Tyr Met Asn 
1               5   


<210>  173
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-13 and Ab-14 HCDR2

<400>  173

Asp Ile Asn Pro Tyr Asn Asp Asp Thr Thr Tyr Asn His Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-13 and Ab-14 HCDR3

<400>  174

Glu Thr Ala Val Ile Thr Thr Asn Ala Met Asp 
1               5                   10      


<210>  175
<211>  645
<212>  DNA
<213>  Mus musculus

<400>  175
cagattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gggccagctc aagtgtaact tccagttact tgaactggta ccagcagaag      120

ccaggatctt cccccaaact ctggatttat agcacatcca acctggcttc aggagtccca      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagtgtggag      240

gctgaggatg ctgccactta ttactgccag cagtatgatt ttttcccatc gacgttcggt      300

ggaggcacca agctggaaat caagcgggct gatgctgcac caactgtatc catcttccca      360

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      420

taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      480

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      540

acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      600

acatcaactt cacccatcgt caagagcttc aacaggaatg agtgt                      645


<210>  176
<211>  215
<212>  PRT
<213>  Mus musculus

<400>  176

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Phe Phe Pro 
                85                  90                  95      


Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  177
<211>  1335
<212>  DNA
<213>  Mus musculus

<400>  177
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgtaagg cttctggata cacattcact gactactaca tgaactgggt gaagcagagc      120

catggagaga gccttgagtg gattggagat attaatcctt acaacgatga tactacctac      180

aaccacaagt tcaagggcaa ggccacattg actgtagaca aatcctccaa cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagagagacg      300

gccgttatta ctacgaatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact      420

aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg      480

acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct      540

gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc      600

gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc      660

agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc      720

ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt      780

gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg      840

gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca      900

gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg      960

gtcaacagtg cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga     1020

ccgaaggctc cacaggtgta caccattcca cctcccaagg agcagatggc caaggataaa     1080

gtcagtctga cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag     1140

tggaatgggc agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc     1200

tcttacttca tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact     1260

ttcacctgct ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc     1320

cactctcctg gtaaa                                                      1335


<210>  178
<211>  445
<212>  PRT
<213>  Mus musculus

<400>  178

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Asp Asp Thr Thr Tyr Asn His Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Val Ile Thr Thr Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  179
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  179
gacatccagc tgacccagag ccccagcttc ctttccgcat ccgttggtga ccgagtaaca       60

atcacatgcc gcgcctcatc ttcagttaca tcttcttatc ttaattggta tcaacaaaaa      120

ccaggaaaag cacctaaact tcttatatac tctacatcta atctcgcatc aggagttccc      180

tctcgatttt caggatctgg atcaggcaca gaatttacac ttactatatc atcactccaa      240

ccagaagact tcgccactta ttactgccaa caatacgatt tttttccaag cacattcgga      300

ggaggtacaa aagtagaaat caag                                             324


<210>  180
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  180

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Phe Phe Pro 
                85                  90                  95      


Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  181
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  181
gaggtgcagc tggtgcagag cggcgccgag gtcaagaaac ctggagcaag cgtaaaggtt       60

agttgcaaag catctggata cacatttacc gactactaca tgaattgggt acgacaagcc      120

cctggacaaa gacttgaatg gatgggagac attaaccctt ataacgacga cactacatac      180

aatcataaat ttaaaggaag agttacaatt acaagagata catccgcatc aaccgcctat      240

atggaacttt cctcattgag atctgaagac actgctgttt attactgtgc aagagaaact      300

gccgttatta ctactaacgc tatggattac tggggtcaag gaaccactgt taccgtctct      360

agt                                                                    363


<210>  182
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  182

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Asp Asp Thr Thr Tyr Asn His Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Val Ile Thr Thr Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  183
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  183
gaggtgcagc tggtgcagag cggcgccgag gtcaagaaac ctggagcaag cgtaaaggtt       60

agttgcaaag catctggata cacatttacc gactactaca tgaattgggt acgacaagcc      120

cctggacaaa gacttgaatg gatgggagac attaaccctt ataacgacga cactacatac      180

aatcataaat ttaaaggaag agttacaatt acaagagata catccgcatc aaccgcctat      240

atggaacttt cctcattgag atctgaagac actgctgttt attactgtgc aagagaaact      300

gccgttatta ctactaacgc tatggattac tggggtcaag gaaccactgt taccgtctct      360

agt                                                                    363


<210>  184
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  184

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Phe Phe Pro 
                85                  90                  95      


Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  185
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  185
gaggtgcagc tggtgcagag cggcgccgag gtcaagaaac ctggagcaag cgtaaaggtt       60

agttgcaaag catctggata cacatttacc gactactaca tgaattgggt acgacaagcc      120

cctggacaaa gacttgaatg gatgggagac attaaccctt ataacgacga cactacatac      180

aatcataaat ttaaaggaag agttacaatt acaagagata catccgcatc aaccgcctat      240

atggaacttt cctcattgag atctgaagac actgctgttt attactgtgc aagagaaact      300

gccgttatta ctactaacgc tatggattac tggggtcaag gaaccactgt taccgtctct      360

agtgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  186
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  186

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Asp Asp Thr Thr Tyr Asn His Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Val Ile Thr Thr Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  187
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-17 and Ab-18 LCDR1

<400>  187

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-17 and Ab-18 LCDR2

<400>  188

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  189
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  189

Gln Gln Trp Thr Thr Thr Tyr Thr 
1               5               


<210>  190
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-17 and Ab-18 HCDR1

<400>  190

Asp Tyr Tyr Ile His 
1               5   


<210>  191
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-17 and Ab-18 HCDR2

<400>  191

Arg Ile Asp Pro Asp Asn Gly Glu Ser Thr Tyr Val Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  192
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  192

Glu Gly Leu Asp Tyr Gly Asp Tyr Tyr Ala Val Asp Tyr 
1               5                   10              


<210>  193
<211>  390
<212>  DNA
<213>  Mus musculus

<400>  193
atggattttc aggtgcagat tttcagcttc atgctaatca gtgtcacagt catattgtcc       60

agtggagaaa ttgtgctcac ccagtctcca gcactcatgg ctgcatctcc aggggagaag      120

gtcaccatca cctgcagtgt cagctcgagt ataagttcca gcaacttaca ctggtcccag      180

cagaagtcag gaacctcccc caaactctgg atttatggca catccaacct tgcttctgga      240

gtccctgttc gcttcagtgg cagtggatct gggacctctt attctctcac aatcagcagc      300

atggaggctg aagatgctgc cacttattac tgtcaacagt ggactactac gtatacgttc      360

ggatcgggga ccaagctgga gctgaaacgt                                       390


<210>  194
<211>  130
<212>  PRT
<213>  Mus musculus

<400>  194

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Met Leu Ile Ser Val Thr 
1               5                   10                  15      


Val Ile Leu Ser Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ala Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Asn Leu His Trp Ser Gln Gln Lys Ser Gly 
    50                  55                  60                  


Thr Ser Pro Lys Leu Trp Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Trp Thr Thr Thr Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg 
    130 


<210>  195
<211>  423
<212>  DNA
<213>  Mus musculus

<400>  195
atgggatgga actggatcat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gtgcagttgc ggcagtctgg ggcagacctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac tactatatac actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgata atggtgaaag tacatatgtc      240

ccgaagttcc agggcaaggc cactataaca gcagacacat catccaacac agcctaccta      300

caactcagaa gcctgacatc tgaggacact gccatctatt attgtgggag agaggggctc      360

gactatggtg actactatgc tgtggactac tggggtcaag gaacctcggt cacagtctcg      420

agc                                                                    423


<210>  196
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  196

Met Gly Trp Asn Trp Ile Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Arg Gln Ser Gly Ala Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Tyr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Asp Asn Gly Glu Ser Thr Tyr Val 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Gly Arg Glu Gly Leu Asp Tyr Gly Asp Tyr Tyr Ala Val 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210>  197
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  197
atggatatgc gcgtgccggc gcagctgctg ggcctgctgc tgctgtggct gccgggcgcg       60

cgctgcgata ttcagctgac ccagagcccg agctttctga gcgcgagcgt gggcgatcgc      120

gtgaccatta cctgcagcgt gagcagcagc attagcagca gcaacctgca ttggtatcag      180

cagaaaccgg gcaaagcgcc gaaactgctg atttatggca ccagcaacct ggcgagcggc      240

gtgccgagcc gctttagcgg cagcggcagc ggcaccgaat ttaccctgac cattagcagc      300

ctgcagccgg aagattttgc gacctattat tgccagcagt ggaccaccac ctataccttt      360

ggccagggca ccaaactgga aattaaacgt                                       390


<210>  198
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  198

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Asn Leu His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Trp Thr Thr Thr Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg 
    130 


<210>  199
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  199
atggattgga cctggagcat tctgtttctg gtggcggcgc cgaccggcgc gcatagcgaa       60

gtgcagctgg tgcagagcgg cgcggaagtg aaaaaaccgg gcgcgagcgt gaaagtgagc      120

tgcaaagcga gcggctttaa cattaaagat tattatattc attgggtgcg ccaggcgccg      180

ggccagggcc tggaatggat gggccgcatt gatccggata acggcgaaag cacctatgtg      240

ccgaaatttc agggccgcgt gaccatgacc accgatacca gcaccagcac cgcgtatatg      300

gaactgcgca gcctgcgcag cgatgatacc gcggtgtatt attgcgcgcg cgaaggcctg      360

gattatggcg attattatgc ggtggattat tggggccagg gcaccctggt gaccgtctcg      420

agc                                                                    423


<210>  200
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  200

Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Pro Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Ile Asp Pro Asp Asn Gly Glu Ser Thr Tyr Val 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Leu Asp Tyr Gly Asp Tyr Tyr Ala Val 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140     


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-19, Ab-20 and Ab-23 LCDR1

<400>  201

Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-19, Ab-20 and Ab-23 LCDR2

<400>  202

Ser Thr Ser Arg Leu Asn Ser 
1               5           


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-19, Ab-20 and Ab-23 LCDR3

<400>  203

Gln Gln Asp Ile Lys His Pro Thr 
1               5               


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-19, Ab-20 and Ab-23 HCDR1

<400>  204

Asp Tyr Ile Met His 
1               5   


<210>  205
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-19, Ab-20 and Ab-23 HCDR2

<400>  205

Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  206
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-19, Ab-20 and Ab-23 HCDR3

<400>  206

Ser Ile Tyr Tyr Tyr Asp Ala Pro Phe Ala Tyr 
1               5                   10      


<210>  207
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  207

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Arg Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Ala Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Ile Lys His Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  208
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  208

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Gly Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ile Tyr Tyr Tyr Asp Ala Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  209
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  209
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcaac      120

atcagctgca gggcaagtca ggacattagc agttatttaa actggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctactcc acatcaagat taaactcagg agtcccatca      240

aggttcagtg gcagtgggtc tgggacagat tattctctca ctattagcaa cctggcacaa      300

gaagatattg ccacttactt ttgccaacag gatattaagc atccgacgtt cggtggaggc      360

accaagttgg agctgaaacg t                                                381


<210>  210
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  210

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Asn Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Thr Ser Arg Leu Asn Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Ala Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Ile 
            100                 105                 110         


Lys His Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125         


<210>  211
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  211
atggaatgga tctggatatt tctcttcctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagctg gtaaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctgggttcac attcactgac tacattatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat tggatatatt aatccttaca atgatgatac tgaatacaat      240

gagaagttca aaggcaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gatctcagca gtctgacctc tgagggctct gcggtctatt actgtgcaag atcgatttat      360

tactacgatg ccccgtttgc ttactggggc caagggactc tggtcacagt ctcgagc         417


<210>  212
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  212

Met Glu Trp Ile Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ile Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Asp Leu Ser Ser Leu Thr Ser Glu Gly Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Ile Tyr Tyr Tyr Asp Ala Pro Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 


<210>  213
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  213
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggtga ccgtgtcacc      120

atcacttgcc gcgcaagtca ggatattagc agctatttaa attggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatctattct acttcccgtt tgaatagtgg ggtcccatca      240

cgcttcagtg gcagtggctc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacag gatattaaac accctacgtt cggtcaaggc      360

accaaggtgg agatcaaacg t                                                381


<210>  214
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  214

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Thr Ser Arg Leu Asn Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Ile 
            100                 105                 110         


Lys His Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125         


<210>  215
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  215
atggaatgga tctggatatt tctcttcctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc      120

tgcaaggctt ctggttttac cttcaccgac tatattatgc actgggtgcg tcaggcccct      180

ggtcaagggc ttgagtggat gggctatatc aacccttata atgatgacac cgaatacaac      240

gagaagttca agggccgtgt cacgattacc gcggacaaat ccacgagcac agcctacatg      300

gagctgagca gcctgcgctc tgaggacacg gccgtgtatt actgtgcgcg ttcgatttat      360

tactacgatg ccccgtttgc ttactggggc caagggactc tggtcacagt ctcgagc         417


<210>  216
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  216

Met Glu Trp Ile Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Ile Tyr Tyr Tyr Asp Ala Pro Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 


<210>  217
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  217
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggtga ccgtgtcacc       60

atcacttgcc gcgcaagtca ggatattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct acttcccgtt tgaatagtgg ggtcccatca      180

cgcttcagtg gcagtggctc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag gatattaaac accctacgtt cggtcaaggc      300

accaaggtgg agatcaaa                                                    318


<210>  218
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  218

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Arg Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Ile Lys His Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  219
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  219
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggttt taccttcacc gactatatta tgcactgggt gcgtcaggcc      120

cctggtcaag ggcttgagtg gatgggctat atcaaccctt ataatgatga caccgaatac      180

aacgagaagt tcaagggccg tgtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgcg ctctgaggac acggccgtgt attactgtgc gcgttcgatt      300

tattactacg atgccccgtt tgcttactgg ggccaaggga ctctggtcac cgtctctagt      360


<210>  220
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  220

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ile Tyr Tyr Tyr Asp Ala Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  221
<211>  639
<212>  DNA
<213>  Mus musculus

<400>  221
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggtga ccgtgtcacc       60

atcacttgcc gcgcaagtca ggatattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct acttcccgtt tgaatagtgg ggtcccatca      180

cgcttcagtg gcagtggctc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag gatattaaac accctacgtt cggtcaaggc      300

accaaggtgg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  222
<211>  213
<212>  PRT
<213>  Mus musculus

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Arg Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Ile Lys His Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  223
<211>  1338
<212>  DNA
<213>  Mus musculus

<400>  223
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggttt taccttcacc gactatatta tgcactgggt gcgtcaggcc      120

cctggtcaag ggcttgagtg gatgggctat atcaaccctt ataatgatga caccgaatac      180

aacgagaagt tcaagggccg tgtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgcg ctctgaggac acggccgtgt attactgtgc gcgttcgatt      300

tattactacg atgccccgtt tgcttactgg ggccaaggga ctctggtcac cgtctctagt      360

gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag      420

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      600

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      660

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      900

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  224
<211>  446
<212>  PRT
<213>  Mus musculus

<400>  224

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ile Tyr Tyr Tyr Asp Ala Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  225
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-21 and Ab-22 LCDR1

<400>  225

Lys Ala Ser Gln Asp Val Phe Thr Ala Val Ala 
1               5                   10      


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-21 and Ab-22 LCDR2

<400>  226

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  227
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-21 and Ab-22 LCDR3

<400>  227

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  228
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-21 and Ab-22 HCDR1

<400>  228

Asp Tyr Tyr Met His 
1               5   


<210>  229
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-21 and Ab-22 HCDR2

<400>  229

Arg Ile Asp Pro Glu Asn Gly Asp Ile Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  230
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab-21 and Ab-22 HCDR3

<400>  230

Asp Ala Gly Asp Pro Ala Trp Phe Thr Tyr 
1               5                   10  


<210>  231
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  231
atgaagtcac agacccaggt ctttgtatac atgttgctgt ggttgtctgg tgttgaagga       60

gacattgtga tgacccagtc tcacaaattc atgtccacgt cagtaggaga cagggtcacc      120

atcacctgca aggccagtca ggatgtcttt actgctgtag cctggtatca acagaaacca      180

ggacaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      300

gaagacttgg cagattattt ctgtcaacaa tatagcagct atcctctcac gttcggtgct      360

gggaccaagt tggagctgaa a                                                381


<210>  232
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  232

Met Lys Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Phe Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


<210>  233
<211>  411
<212>  DNA
<213>  Mus musculus

<400>  233
atgggatgga actggatcat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggctgagctt gtgaggccag gggccttagt caagttgtcc      120

tgcaaagctt ctggcttcaa tattaaagac tactatatgc actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgaga atggtgatat tatatatgac      240

ccgaagttcc agggcaaggc cagtataaca acagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacgtc tgaggacact gccgtctatt actgtgctta cgatgctggt      360

gaccccgcct ggtttactta ctggggccaa gggactctgg tcaccgtctc g               411


<210>  234
<211>  138
<212>  PRT
<213>  Mus musculus

<400>  234

Met Gly Trp Asn Trp Ile Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Tyr Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Glu Asn Gly Asp Ile Ile Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Ser Ile Thr Thr Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Tyr Asp Ala Gly Asp Pro Ala Trp Phe Thr Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135             


<210>  235
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  235
gatatccaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgca aagcgagcca ggatgtgttt accgcggtgg cgtggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttattgg gcgagcaccc gccataccgg cgtgccgagt      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcag tatagcagct atccgctgac ctttggcggc      300

ggcaccaaag tggaaattaa acgt                                             324


<210>  236
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  236

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Phe Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  237
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  237
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggctt taacattaaa gattattata tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gatcggccgc attgatccgg aaaacggcga tattatttat      180

gatccgaaat ttcagggccg cgtgaccatg accaccgata ccagcaccag caccgcgtat      240

atggaactgc gcagcctgcg cagcgatgat accgcggtgt attattgcgc gtatgatgcg      300

ggcgatccgg cgtggtttac ctattggggc cagggcaccc tggtgaccgt ctcgagc         357


<210>  238
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  238

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Asp Ile Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Asp Ala Gly Asp Pro Ala Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  239
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  239

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Thr Ser Tyr Met Asn 
1               5                   10                  15  


<210>  240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  240

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  241
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  241

Gln Gln Ser Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  242
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  242

Thr Tyr Trp Met Asn 
1               5   


<210>  243
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  243

Met Ile His Pro Ser Ala Ser Glu Ile Arg Leu Asp Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  244

Ser Gly Glu Trp Gly Ser Met Asp Tyr 
1               5                   


<210>  245
<211>  657
<212>  DNA
<213>  Mus musculus

<400>  245
gacattgtgt tgacccagtc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atcgcctgca aggccagcca aagtgttgat tatgatggta ctagttatat gaattggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gagatcccag ccaggtttag tggcactggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatat cacaacctat tactgtcagc aaagtaatga ggatccgttc      300

acgttcggag gggggaccaa gttggaaata aaacgggctg atgctgcacc aactgtatcc      360

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      420

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      480

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      540

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      600

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag         657


<210>  246
<211>  218
<212>  PRT
<213>  Mus musculus

<400>  246

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ala Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Thr Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Glu Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Thr Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ile Thr Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  247
<211>  442
<212>  PRT
<213>  Mus musculus

<400>  247

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Ala Ser Glu Ile Arg Leu Asp Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Gly Pro Thr Ser Val Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Glu Trp Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440         


<210>  248
<211>  1329
<212>  DNA
<213>  Mus musculus

<400>  248
caggtccaac tacagcagcc tgggactgag ctggtgaggc ctggaacttc agtgaagttg       60

tcctgtaagg cttctggcta catcttcacc acctactgga tgaactgggt gaaacagagg      120

cctggacaag gccttgagtg gattggcatg attcatcctt ccgcaagtga aattaggttg      180

gatcagaaat tcaaggacaa ggccacattg actcttgaca aatcctccag cacagcctat      240

atgcacctca gcggcccgac atctgtggat tctgcggtct attactgtgc aagatcaggg      300

gaatgggggt ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcagccaaa      360

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      420

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      480

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac      540

actctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac cgtcacctgc      600

aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt      660

ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca      720

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac      780

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac      840

acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc agtcagtgaa      900

cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtcaacagt      960

gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct     1020

ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg     1080

acctgcatga taacagactt cttccctgaa gacattactg tggagtggca gtggaatggg     1140

cagccagcgg agaactacaa gaacactcag cccatcatgg acacagatgg ctcttacttc     1200

atctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc     1260

tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct     1320

ggtaaatga                                                             1329


