                         SEQUENCE LISTING

<110>  GEVO, INC.
       CALIFORNIA INSTITUTE OF TECHNOLOGY	
       Buelter, Thomas
       Hawkins, Andrew
       Porter-Scheinman, Stephanie
       Meinhold, Peter
       Dundon, Catherine Asleson
       Aristidou, Aristos
       Urano, Jun
       Lies, Doug
       Peters, Matthew
       Dey, Melissa
       Jancauskas, Justas
       Evans, Kent
       Kelly, Julie
       Berry, Ruth
       Bastian, Sabine 
       Arnold, Frances 
 
<120>  Yeast Microorganisms with Reduced By-Product Accumulation for 
       Improved Production of Fuels, Chemicals, and Amino Acids

<130>  GEVO-045/03WO

<150>  US 61/304,069
<151>  2010-02-12

<150>  US 61/308,568
<151>  2010-02-26

<150>  US 61/282,641
<151>  2010-03-10

<150>  US 61/352,133
<151>  2010-06-07

<150>  US 61/411,885
<151>  2010-11-09

<150>  US 61/430,801
<151>  2010-01-07

<160>  268   

<170>  PatentIn version 3.5

<210>  1
<211>  267
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Ser Gln Gly Arg Lys Ala Ala Glu Arg Leu Ala Lys Lys Thr Val 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ala Gly Ile Gly Lys Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Glu Ala Ser Asn Gly Asp Met Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Glu Glu Leu Lys Lys Thr Ile Asp Gln Glu Phe 
    50                  55                  60                  


Pro Asn Ala Lys Val His Val Ala Gln Leu Asp Ile Thr Gln Ala Glu 
65                  70                  75                  80  


Lys Ile Lys Pro Phe Ile Glu Asn Leu Pro Gln Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Arg Val 
            100                 105                 110         


Gly Gln Ile Ala Thr Glu Asp Ile Gln Asp Val Phe Asp Thr Asn Val 
        115                 120                 125             


Thr Ala Leu Ile Asn Ile Thr Gln Ala Val Leu Pro Ile Phe Gln Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Ile Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Ser Lys Phe Ala Val Gly 
                165                 170                 175     


Ala Phe Thr Asp Ser Leu Arg Lys Glu Leu Ile Asn Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Leu Ile Ala Pro Gly Leu Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Arg Gly Asn Glu Glu Gln Ala Lys Asn Val Tyr Lys Asp Thr 
    210                 215                 220                 


Thr Pro Leu Met Ala Asp Asp Val Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu Ile Phe Pro Thr 
                245                 250                 255     


Asn Gln Ala Ser Pro His His Ile Phe Arg Gly 
            260                 265         


<210>  2
<211>  267
<212>  PRT
<213>  Kabatiella polyspora

<400>  2

Met Ser Gln Gly Arg Lys Ala Ser Glu Arg Leu Ala Gly Lys Thr Val 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Lys Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Asp Ala Ser Asn Gly His Met Lys Leu Ile Leu Val Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Gln Glu Leu Lys Glu Thr Ile Cys Lys Glu Tyr 
    50                  55                  60                  


Pro Glu Ser Lys Val His Val Glu Glu Leu Asp Ile Ser Asp Ile Asn 
65                  70                  75                  80  


Arg Ile Pro Glu Phe Ile Ala Lys Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Thr Ile 
            100                 105                 110         


Gly Asn Ile Glu Asn Glu Asp Ile Lys Gly Met Phe Glu Thr Asn Val 
        115                 120                 125             


Phe Gly Leu Ile Cys Leu Thr Gln Ala Val Leu Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Gly Gly Asp Ile Val Asn Leu Gly Ser Ile Ala Gly Ile Glu 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Thr Lys Phe Ala Val Lys 
                165                 170                 175     


Ala Phe Thr Glu Ser Leu Arg Lys Glu Leu Ile Asn Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Ala Pro Gly Met Val Asn Thr Glu Phe Ser Val Ile 
        195                 200                 205             


Arg Tyr Lys Gly Asp Gln Glu Lys Ala Asp Lys Val Tyr Glu Asn Thr 
    210                 215                 220                 


Thr Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Thr Thr 
225                 230                 235                 240 


Ser Arg Lys Ser Asn Thr Val Ile Ala Asp Val Leu Val Phe Pro Thr 
                245                 250                 255     


Cys Gln Ala Ser Ala Ser His Ile Tyr Arg Gly 
            260                 265         


<210>  3
<211>  267
<212>  PRT
<213>  Saccharomyces castellii

<400>  3

Met Ser Gln Gly Pro Lys Ala Ala Glu Arg Leu Asn Glu Lys Ile Val 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Gln Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Met Asp Ala Ser Asn Gly Thr Val Lys Leu Val Leu Val Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Gln Gln Leu Lys Glu Val Ile Glu Ala Lys Tyr 
    50                  55                  60                  


Pro Lys Ser Lys Val Tyr Ile Gly Lys Leu Asp Val Thr Glu Leu Glu 
65                  70                  75                  80  


Thr Ile Gln Pro Phe Leu Asp Asn Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Arg Val 
            100                 105                 110         


Gly Asp Ile Asp Ile Lys Asp Val Lys Gly Met Met Asp Thr Asn Val 
        115                 120                 125             


Leu Gly Leu Ile Asn Val Thr Gln Ala Val Leu His Ile Phe Gln Lys 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Ser Lys Phe Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Glu Ser Leu Arg Arg Glu Leu Ile Asn Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Leu Ile Ala Pro Gly Ile Val Glu Thr Glu Phe Ser Val Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Asn Glu Arg Ala Lys Ser Val Tyr Asp Gly Val 
    210                 215                 220                 


His Pro Leu Glu Ala Asp Asp Val Ala Asp Leu Ile Val Tyr Thr Thr 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu Ile Phe Pro Thr 
                245                 250                 255     


Ser Gln Gly Ser Ala Phe His Val His Arg Asp 
            260                 265         


<210>  4
<211>  268
<212>  PRT
<213>  Candida glabrata

<400>  4

Met Ser Gln Gly Arg Lys Ala Ala Glu Arg Leu Gln Gly Lys Ile Ala 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Lys Ala Thr Ala Ile Glu 
            20                  25                  30          


Tyr Leu Asp Ala Ser Asn Gly Ser Val Lys Leu Val Leu Gly Ala Arg 
        35                  40                  45              


Arg Met Glu Lys Leu Glu Glu Leu Lys Lys Glu Leu Leu Ala Gln Tyr 
    50                  55                  60                  


Pro Asp Ala Lys Ile His Ile Gly Lys Leu Asp Val Thr Asp Phe Glu 
65                  70                  75                  80  


Asn Val Lys Gln Phe Leu Ala Asp Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Lys Val 
            100                 105                 110         


Gly Asp Ile Asp Pro Glu Asp Ile Ala Gly Met Val Asn Thr Asn Val 
        115                 120                 125             


Leu Ala Leu Ile Asn Leu Thr Gln Leu Leu Leu Pro Leu Phe Lys Lys 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Ile Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ala Ile Tyr Cys Ala Thr Lys His Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Gln Ser Leu Arg Lys Glu Leu Ile Asn Thr Asp Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Ala Pro Gly Met Val Glu Thr Glu Phe Ser Val Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Lys Ser Lys Ala Asp Asp Val Tyr Arg Gly Thr 
    210                 215                 220                 


Thr Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ser Thr 
225                 230                 235                 240 


Ser Arg Lys Pro Asn Met Val Val Ala Asp Val Leu Val Phe Pro Thr 
                245                 250                 255     


His Gln Ala Ser Ala Ser His Ile Tyr Arg Gly Asp 
            260                 265             


<210>  5
<211>  267
<212>  PRT
<213>  Saccharomyces bayanus

<400>  5

Met Ser Gln Gly Arg Lys Ala Ala Glu Arg Leu Ala Asn Lys Thr Val 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ala Gly Ile Gly Lys Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Glu Ala Ser Asn Gly Asn Met Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Glu Glu Leu Lys Lys Thr Ile Asp Glu Glu Phe 
    50                  55                  60                  


Pro Asn Ala Lys Val His Val Gly Gln Leu Asp Ile Thr Gln Ala Glu 
65                  70                  75                  80  


Lys Ile Lys Pro Phe Ile Glu Asn Leu Pro Glu Ala Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Glu Arg Val 
            100                 105                 110         


Gly Glu Ile Ala Thr Gln Asp Ile Gln Asp Val Phe Asp Thr Asn Val 
        115                 120                 125             


Thr Ala Leu Ile Asn Val Thr Gln Ala Val Leu Pro Ile Phe Gln Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Ser Lys Phe Ala Val Gly 
                165                 170                 175     


Ala Phe Thr Asp Ser Leu Arg Lys Glu Leu Ile Asn Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Leu Ile Ala Pro Gly Leu Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Arg Gly Asn Glu Glu Gln Ala Lys Asn Val Tyr Lys Asp Thr 
    210                 215                 220                 


Thr Pro Leu Met Ala Asp Asp Val Ala Asp Leu Ile Val Tyr Ser Thr 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Thr Val Val Ala Asp Thr Leu Ile Phe Pro Thr 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Ile Phe Arg Gly 
            260                 265         


<210>  6
<211>  273
<212>  PRT
<213>  Zygosaccharomyces rouxii

<400>  6

Met Ser Gln Gly Val Lys Ala Ala Glu Arg Leu Ala Gly Lys Thr Val 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Gln Ala Thr Ala Lys Glu 
            20                  25                  30          


Tyr Leu Asp Ala Ser Asn Gly Gln Ile Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu His Glu Phe Lys Glu Gln Thr Thr Lys Ser Tyr 
    50                  55                  60                  


Pro Ser Ala Gln Val His Ile Gly Lys Leu Asp Val Thr Ala Ile Asp 
65                  70                  75                  80  


Thr Ile Lys Pro Phe Leu Asp Lys Leu Pro Lys Glu Phe Gln Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Thr Asp Lys Val 
            100                 105                 110         


Gly Asp Ile Ala Asp Glu Asp Val Glu Gly Met Phe Asp Thr Asn Val 
        115                 120                 125             


Leu Gly Leu Ile Lys Val Thr Gln Ala Val Leu Pro Ile Phe Lys Arg 
    130                 135                 140                 


Lys Asn Ser Gly Asp Val Val Asn Ile Ser Ser Val Ala Gly Arg Glu 
145                 150                 155                 160 


Ala Tyr Pro Gly Gly Ser Ile Tyr Cys Ala Thr Lys His Ala Val Lys 
                165                 170                 175     


Ala Phe Thr Glu Ser Leu Arg Lys Glu Leu Val Asp Thr Lys Ile Arg 
            180                 185                 190         


Val Met Ser Ile Asp Pro Gly Asn Val Glu Thr Glu Phe Ser Met Val 
        195                 200                 205             


Arg Phe Arg Gly Asp Thr Glu Lys Ala Lys Lys Val Tyr Gln Asp Thr 
    210                 215                 220                 


Val Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu Ile Phe Ser Ser 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Leu Tyr Arg Gly Ser Gln Asp Lys Thr 
            260                 265                 270         


Asn 
    


<210>  7
<211>  268
<212>  PRT
<213>  Kluyveromyces lactis

<400>  7

Met Ser Gln Gly Arg Lys Ala Ala Glu Arg Leu Gln Asn Lys Thr Ile 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Gln Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Asp Ala Ala Asn Gly Asn Val Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Ala Lys Leu Glu Glu Leu Lys Glu Lys Ile Asn Ala Glu Tyr 
    50                  55                  60                  


Pro Gln Ala Lys Val Tyr Ile Gly Gln Leu Asp Val Thr Glu Thr Glu 
65                  70                  75                  80  


Lys Ile Gln Pro Phe Ile Asp Asn Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Val Val 
            100                 105                 110         


Gly Thr Ile Ser Ser Glu Asp Ile Lys Gly Met Ile Asp Thr Asn Val 
        115                 120                 125             


Val Ala Leu Ile Asn Val Thr Gln Ala Val Leu Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Ser Lys His Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Gln Ser Leu Arg Lys Glu Leu Ile Asn Thr Gly Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Ala Pro Gly Asn Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Ala Asp Arg Ala Lys Gln Val Tyr Lys Gly Thr 
    210                 215                 220                 


Thr Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Pro Asn Thr Val Ile Ala Asp Val Leu Val Phe Ala Ser 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Ile Tyr Arg Gly Glu 
            260                 265             


<210>  8
<211>  267
<212>  PRT
<213>  Ashbya gossypii

<400>  8

Met Ser Leu Gly Arg Lys Ala Ala Glu Arg Leu Ala Asn Lys Ile Val 
1               5                   10                  15      


Leu Val Thr Gly Ala Ser Ala Gly Ile Gly Arg Ala Thr Ala Ile Asn 
            20                  25                  30          


Tyr Ala Asp Ala Thr Asp Gly Ala Ile Lys Leu Ile Leu Val Ala Arg 
        35                  40                  45              


Arg Ala Glu Lys Leu Thr Ser Leu Lys Gln Glu Ile Glu Ser Lys Tyr 
    50                  55                  60                  


Pro Asn Ala Lys Ile His Val Gly Gln Leu Asp Val Thr Gln Leu Asp 
65                  70                  75                  80  


Gln Ile Arg Pro Phe Leu Glu Gly Leu Pro Glu Glu Phe Arg Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Thr Glu Arg Val 
            100                 105                 110         


Gly Glu Ile Ser Met Asp Asp Ile Gln Glu Val Phe Asn Thr Asn Val 
        115                 120                 125             


Ile Gly Leu Val His Leu Thr Gln Glu Val Leu Pro Ile Met Lys Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Val Gly Ser Ile Ala Gly Arg Glu 
145                 150                 155                 160 


Ala Tyr Pro Gly Gly Ser Ile Tyr Cys Ala Thr Lys His Ala Val Lys 
                165                 170                 175     


Ala Phe Thr Arg Ala Met Arg Lys Glu Leu Ile Ser Thr Lys Ile Arg 
            180                 185                 190         


Val Phe Glu Ile Ala Pro Gly Ser Val Glu Thr Glu Phe Ser Met Val 
        195                 200                 205             


Arg Met Arg Gly Asn Glu Glu Asn Ala Lys Lys Val Tyr Gln Gly Phe 
    210                 215                 220                 


Glu Pro Leu Asp Gly Asp Asp Ile Ala Asp Thr Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Arg Ser Asn Thr Val Val Ala Glu Met Val Val Tyr Pro Ser 
                245                 250                 255     


Ala Gln Gly Ser Leu Tyr Asp Thr His Arg Asn 
            260                 265         


<210>  9
<211>  268
<212>  PRT
<213>  Saccharomyces kluyveri

<400>  9

Met Ser Gln Gly Arg Arg Ala Ala Glu Arg Leu Ala Asn Lys Thr Val 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Gln Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Cys Asp Ala Ser Asn Gly Lys Ile Asn Leu Val Leu Ser Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Gln Glu Leu Lys Asp Lys Ile Thr Lys Glu Tyr 
    50                  55                  60                  


Pro Glu Ala Lys Val Tyr Ile Gly Val Leu Asp Val Thr Glu Thr Glu 
65                  70                  75                  80  


Lys Ile Lys Pro Phe Leu Asp Gly Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Pro Val 
            100                 105                 110         


Gly Thr Ile Lys Thr Glu Asp Ile Glu Gly Met Ile Asn Thr Asn Val 
        115                 120                 125             


Leu Ala Leu Ile Asn Ile Thr Gln Ala Val Leu Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Phe Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ala Ile Tyr Cys Ala Ser Lys His Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Gln Ser Leu Arg Lys Glu Leu Val Asn Thr Asn Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Ala Pro Gly Asn Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Thr Asp Arg Ala Lys Lys Val Tyr Glu Gly Thr 
    210                 215                 220                 


Asn Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Pro Asn Thr Val Ile Ala Asp Val Leu Val Phe Ala Ser 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Ile Tyr Arg Gly Asp 
            260                 265             


<210>  10
<211>  267
<212>  PRT
<213>  Kluyveromyces thermotolerans

<400>  10

Met Ser Gln Gly Arg Arg Ala Ala Glu Arg Leu Ala Gly Lys Thr Val 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Gln Ala Thr Ala Gln Glu 
            20                  25                  30          


Tyr Leu Glu Ala Ser Glu Gly Lys Ile Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Asp Lys Leu Glu Glu Ile Lys Ala Lys Val Ser Lys Asp Phe 
    50                  55                  60                  


Pro Glu Ala Gln Val His Ile Gly Gln Leu Asp Val Thr Gln Thr Asp 
65                  70                  75                  80  


Lys Ile Gln Pro Phe Val Asp Asn Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Pro Val 
            100                 105                 110         


Gly Thr Ile Asp Pro Asn Asp Ile Gln Gly Met Ile Gln Thr Asn Val 
        115                 120                 125             


Ile Gly Leu Ile Asn Val Thr Gln Ala Val Leu Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Glu 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Thr Lys His Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Gln Ser Leu Arg Lys Glu Leu Ile Asn Thr Asn Ile Arg 
            180                 185                 190         


Val Ile Glu Val Ala Pro Gly Asn Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Ser Glu Lys Ala Lys Lys Val Tyr Glu Gly Thr 
    210                 215                 220                 


Gln Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Pro Asn Thr Val Ile Ala Asp Val Leu Val Phe Ala Ser 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Ile Tyr Arg Gly 
            260                 265         


<210>  11
<211>  267
<212>  PRT
<213>  Kluyveromyces waltii

<400>  11

Met Ser Gln Gly Arg Lys Ala Ser Glu Arg Leu Ala Gly Lys Thr Val 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ala Gly Ile Gly Gln Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Asp Ala Ser Asn Gly Asn Ile Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Lys Glu Ile Lys Ser Gln Phe Glu Lys Asp Phe 
    50                  55                  60                  


Pro Glu Ala Lys Val Tyr Ile Gly Gln Leu Asp Val Thr His Thr Asp 
65                  70                  75                  80  


Glu Ile Lys Pro Phe Ile Asp Asn Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Pro Val 
            100                 105                 110         


Gly Thr Ile Asp Ala Ser Asp Ile Glu Gly Met Ile Gln Thr Asn Val 
        115                 120                 125             


Val Ala Leu Ile Asn Met Thr Gln Ala Val Leu Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Ala Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Glu 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Thr Lys His Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Gln Ser Leu Arg Lys Glu Leu Ile Asn Thr Asn Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Ala Pro Gly Asn Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Pro Glu Lys Ala Lys Lys Val Tyr Glu Gly Thr 
    210                 215                 220                 


Thr Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Ser Asn Thr Val Ile Ala Asp Val Leu Val Phe Ala Ser 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Ile Tyr Arg Gly 
            260                 265         


<210>  12
<211>  269
<212>  PRT
<213>  Pichia stipitis

<400>  12

Met Ser Phe Gly Lys Lys Ala Ala Glu Arg Leu Ala Asn Lys Ile Ile 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Glu Ala Thr Ala Arg Glu 
            20                  25                  30          


Phe Ala Ser Ala Ala Asn Gly Asn Ile Arg Leu Ile Leu Thr Ala Arg 
        35                  40                  45              


Arg Lys Glu Lys Leu Ala Gln Leu Ser Asp Ser Leu Thr Lys Glu Phe 
    50                  55                  60                  


Pro Thr Ile Lys Ile His Ser Ala Lys Leu Asp Val Thr Glu His Asp 
65                  70                  75                  80  


Gly Ile Lys Pro Phe Ile Ser Gly Leu Pro Lys Asp Phe Ala Asp Ile 
                85                  90                  95      


Asp Val Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Lys Ala Ser Val 
            100                 105                 110         


Gly Glu Ile Ser Asp Ser Asp Ile Gln Gly Met Met Gln Thr Asn Val 
        115                 120                 125             


Leu Gly Leu Ile Asn Met Thr Gln Ala Val Ile Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Ile Gly Ser Ile Ala Gly Arg Asp 
145                 150                 155                 160 


Pro Tyr Pro Gly Gly Ser Ile Tyr Cys Ala Ser Lys Ala Ala Val Lys 
                165                 170                 175     


Phe Phe Ser His Ser Leu Arg Lys Glu Leu Ile Asn Thr Arg Ile Arg 
            180                 185                 190         


Val Leu Glu Val Asp Pro Gly Ala Val Leu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Phe His Gly Asp Gln Gly Ala Ala Asp Ala Val Tyr Glu Gly Thr 
    210                 215                 220                 


Gln Pro Leu Asp Ala Ser Asp Ile Ala Glu Val Ile Val Phe Gly Ile 
225                 230                 235                 240 


Thr Arg Lys Gln Asn Thr Val Ile Ala Glu Thr Leu Val Phe Pro Ser 
                245                 250                 255     


His Gln Ala Ser Ala Ser His Val Tyr Lys Ala Pro Lys 
            260                 265                 


<210>  13
<211>  270
<212>  PRT
<213>  Debaryomyces hansenii

<400>  13

Met Ser Tyr Gly Ser Lys Ala Ala Glu Arg Val Ala Asn Lys Ile Val 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Glu Ala Thr Ala Lys Glu 
            20                  25                  30          


Ile Ala Ser Ala Ala Asn Gly Asn Leu Lys Leu Val Leu Cys Ala Arg 
        35                  40                  45              


Arg Lys Glu Lys Leu Asp Asn Leu Ser Lys Glu Leu Thr Asp Lys Tyr 
    50                  55                  60                  


Ser Ser Ile Lys Val His Val Ala Gln Leu Asp Val Ser Lys Leu Glu 
65                  70                  75                  80  


Thr Ile Lys Pro Phe Ile Asn Asp Leu Pro Lys Glu Phe Ser Asp Val 
                85                  90                  95      


Asp Val Leu Val Asn Asn Ala Gly Leu Ala Leu Gly Arg Asp Glu Val 
            100                 105                 110         


Gly Thr Ile Asp Thr Asp Asp Met Leu Ser Met Phe Gln Thr Asn Val 
        115                 120                 125             


Leu Gly Leu Ile Thr Ile Thr Gln Ala Val Leu Pro Ile Met Lys Lys 
    130                 135                 140                 


Lys Asn Ser Gly Asp Val Val Asn Ile Gly Ser Ile Ala Gly Arg Asp 
145                 150                 155                 160 


Ser Tyr Pro Gly Gly Gly Ile Tyr Cys Pro Thr Lys Ala Ser Val Lys 
                165                 170                 175     


Ser Phe Ser Gln Val Leu Arg Lys Glu Leu Ile Ser Thr Lys Ile Arg 
            180                 185                 190         


Val Leu Glu Val Asp Pro Gly Asn Val Glu Thr Glu Phe Ser Asn Val 
        195                 200                 205             


Arg Phe Lys Gly Asp Met Glu Lys Ala Lys Ser Val Tyr Ala Gly Thr 
    210                 215                 220                 


Glu Pro Leu Leu Ser Glu Asp Val Ala Glu Val Val Val Phe Gly Leu 
225                 230                 235                 240 


Thr Arg Lys Gln Asn Thr Val Ile Ala Glu Thr Leu Val Phe Ser Thr 
                245                 250                 255     


Asn Gln Ala Ser Ser Ser His Leu Tyr Arg Glu Ser Asp Lys 
            260                 265                 270 


<210>  14
<211>  269
<212>  PRT
<213>  Pichia pastoris

<400>  14

Met Ser Tyr Gly Leu Ala Ala Ala Ser Arg Leu Ala Gly Lys Val Ile 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Glu Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Ala Asn Ala Ala Lys Gly Glu Ile Lys Leu Ala Leu Ser Ala Arg 
        35                  40                  45              


Arg Phe Glu Lys Leu Glu Gly Leu Lys Glu Lys Leu Thr Thr Gln Trp 
    50                  55                  60                  


Pro Asn Ile Lys Val His Ile Ala Leu Leu Asp Val Ser Asn Ile Ala 
65                  70                  75                  80  


Lys Leu Thr Glu Tyr Val Glu Ser Leu Pro Glu Glu Phe Lys Ala Val 
                85                  90                  95      


Asp Val Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Ile Asp Arg Val 
            100                 105                 110         


Gly Gln Ile Leu Gln Glu Asp Ile Asp Gly Met Phe Gln Thr Asn Val 
        115                 120                 125             


Ile Gly Leu Ile Ser Leu Thr Gln Leu Ile Leu Pro Gly Met Lys Ala 
    130                 135                 140                 


Arg Asn Arg Gly Asp Ile Ile Gln Leu Gly Ser Ile Ala Gly Arg Asp 
145                 150                 155                 160 


Pro Tyr Pro Gly Gly Gly Ile Tyr Cys Ala Thr Lys Ala Ala Val Arg 
                165                 170                 175     


Ser Phe Ser His Ser Leu Arg Lys Glu Leu Ile Asp Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Asp Pro Gly Ala Val Gln Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Lys Gly Ser Lys Glu Ser Ala Ser Lys Val Tyr Glu Gly Ala 
    210                 215                 220                 


Glu Pro Leu Asn Ala Leu Asp Ile Ala Glu Leu Ile Val Phe Ala Ser 
225                 230                 235                 240 


Thr Arg Arg Glu Asn Thr Val Val Ala Glu Thr Leu Val Phe Pro Thr 
                245                 250                 255     


Asn Gln Ala Gly Ala Gly Tyr Val Tyr Arg Lys Lys Asp 
            260                 265                 


<210>  15
<211>  268
<212>  PRT
<213>  Candida dubliniensis

<400>  15

Met Ser Phe Gly Arg Lys Ala Ala Glu Arg Leu Ala Asn Arg Ser Ile 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Glu Ala Cys Ala Lys Val 
            20                  25                  30          


Phe Ala Glu Ala Ser Asn Gly Gln Val Lys Leu Val Leu Gly Ala Arg 
        35                  40                  45              


Arg Lys Glu Arg Leu Val Lys Leu Ser Asp Thr Leu Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Asn Ile Lys Ile His His Asp Phe Leu Asp Val Thr Ile Lys Asp 
65                  70                  75                  80  


Ser Ile Ser Lys Phe Ile Ala Gly Ile Pro His Glu Phe Glu Pro Asp 
                85                  90                  95      


Val Leu Ile Asn Asn Ser Gly Lys Ala Leu Gly Lys Glu Glu Val Gly 
            100                 105                 110         


Glu Leu Lys Asp Glu Asp Ile Thr Glu Met Phe Asp Thr Asn Val Ile 
        115                 120                 125             


Gly Val Ile Arg Met Thr Gln Ala Val Leu Pro Leu Leu Lys Lys Lys 
    130                 135                 140                 


Pro Tyr Ala Asp Val Val Phe Ile Gly Ser Ile Ala Gly Arg Val Pro 
145                 150                 155                 160 


Tyr Lys Asn Gly Gly Gly Tyr Cys Ala Ser Lys Ala Ala Val Arg Ser 
                165                 170                 175     


Phe Thr Asp Thr Phe Arg Lys Glu Thr Ile Asn Thr Gly Ile Arg Val 
            180                 185                 190         


Ile Glu Val Asp Pro Gly Ala Val Leu Thr Glu Phe Ser Val Val Arg 
        195                 200                 205             


Tyr Lys Gly Asp Thr Asp Ala Ala Asp Ala Val Tyr Thr Gly Thr Glu 
    210                 215                 220                 


Pro Leu Thr Pro Glu Asp Val Ala Glu Val Val Val Phe Ala Ser Ser 
225                 230                 235                 240 


Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu Ile Phe Pro Asn His 
                245                 250                 255     


Gln Ala Ser Pro Asp His Val Tyr Arg Lys Pro Asn 
            260                 265             


<210>  16
<211>  268
<212>  PRT
<213>  Candida albicans

<400>  16

Met Ser Phe Gly Arg Lys Ala Ala Glu Arg Leu Ala Asn Arg Ser Ile 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Glu Ala Cys Ala Lys Val 
            20                  25                  30          


Phe Ala Glu Ala Ser Asn Gly Gln Ile Lys Leu Ile Leu Gly Ala Arg 
        35                  40                  45              


Arg Lys Glu Arg Leu Ile Lys Leu Ser Asp Thr Leu Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Asn Ile Lys Ile His His Asp Phe Leu Asp Val Thr Ile Lys Asp 
65                  70                  75                  80  


Ser Ile Ser Lys Phe Ile Ala Gly Ile Pro Thr Asp Phe Glu Pro Asp 
                85                  90                  95      


Val Leu Ile Asn Asn Ser Gly Lys Ala Leu Gly Lys Glu Gln Val Gly 
            100                 105                 110         


Glu Leu Lys Asp Glu Asp Ile Thr Glu Met Leu Asp Thr Asn Val Val 
        115                 120                 125             


Gly Val Ile Arg Met Thr Gln Ala Val Leu Pro Leu Leu Lys Lys Lys 
    130                 135                 140                 


Asn Tyr Ala Asp Val Val Phe Ile Gly Ser Ile Ala Gly Arg Val Ala 
145                 150                 155                 160 


Tyr Lys Asn Gly Gly Gly Tyr Cys Ala Ser Lys Ala Ala Val Arg Ser 
                165                 170                 175     


Phe Val Asp Thr Phe Arg Lys Glu Thr Ile Asp Thr Gly Ile Arg Val 
            180                 185                 190         


Ile Glu Val Asp Pro Gly Ala Val Leu Thr Glu Phe Ser Val Val Arg 
        195                 200                 205             


Tyr Lys Gly Asp Thr Glu Ala Ala Asp Ala Val Tyr Thr Gly Thr Glu 
    210                 215                 220                 


Pro Leu Thr Pro Glu Asp Val Ala Glu Val Val Val Phe Ala Ala Ser 
225                 230                 235                 240 


Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu Ile Phe Pro Asn His 
                245                 250                 255     


Gln Ala Ser Pro Asp His Val Tyr Arg Lys Pro Asn 
            260                 265             


<210>  17
<211>  268
<212>  PRT
<213>  Yarrowia lipolytica

<400>  17

Met Ser Phe Gly Asp Lys Ala Ala Ala Arg Leu Ala Gly Lys Thr Val 
1               5                   10                  15      


Phe Val Thr Gly Ala Ser Ser Gly Ile Gly Gln Ala Thr Val Leu Ala 
            20                  25                  30          


Leu Ala Glu Ala Ala Lys Gly Asp Leu Lys Phe Val Leu Ala Ala Arg 
        35                  40                  45              


Arg Thr Asp Arg Leu Asp Glu Leu Lys Lys Lys Leu Glu Thr Asp Tyr 
    50                  55                  60                  


Lys Gly Ile Gln Val Leu Pro Phe Lys Leu Asp Val Ser Lys Val Glu 
65                  70                  75                  80  


Glu Thr Glu Asn Ile Val Ser Lys Leu Pro Lys Glu Phe Ser Glu Val 
                85                  90                  95      


Asp Val Leu Ile Asn Asn Ala Gly Met Val His Gly Thr Glu Lys Val 
            100                 105                 110         


Gly Ser Ile Asn Gln Asn Asp Ile Glu Ile Met Phe His Thr Asn Val 
        115                 120                 125             


Leu Gly Leu Ile Ser Val Thr Gln Gln Phe Val Gly Glu Met Arg Lys 
    130                 135                 140                 


Arg Asn Lys Gly Asp Ile Val Asn Ile Gly Ser Ile Ala Gly Arg Glu 
145                 150                 155                 160 


Pro Tyr Val Gly Gly Gly Ile Tyr Cys Ala Thr Lys Ala Ala Val Arg 
                165                 170                 175     


Ser Phe Thr Glu Thr Leu Arg Lys Glu Asn Ile Asp Thr Arg Ile Arg 
            180                 185                 190         


Val Ile Glu Val Asp Pro Gly Ala Val Glu Thr Glu Phe Ser Val Val 
        195                 200                 205             


Arg Phe Arg Gly Asp Lys Ser Lys Ala Asp Ala Val Tyr Ala Gly Thr 
    210                 215                 220                 


Glu Pro Leu Val Ala Asp Asp Ile Ala Glu Phe Ile Thr Tyr Thr Leu 
225                 230                 235                 240 


Thr Arg Arg Glu Asn Val Val Ile Ala Asp Thr Leu Ile Phe Pro Asn 
                245                 250                 255     


His Gln Ala Ser Pro Thr His Val Tyr Arg Lys Asn 
            260                 265             


<210>  18
<211>  270
<212>  PRT
<213>  Issatchenkia orientalis

<400>  18

Met Phe Gly Asn Ile Ser Gln Arg Leu Ala Gly Lys Asn Ile Leu Ile 
1               5                   10                  15      


Thr Gly Ala Ser Thr Gly Ile Gly Tyr His Thr Ala Lys Tyr Phe Ala 
            20                  25                  30          


Glu Ala Ala Asn Gly Asp Leu Lys Leu Val Leu Ala Ala Arg Arg Lys 
        35                  40                  45              


Glu Lys Leu Glu Ala Leu Lys Ala Asp Leu Leu Ala Lys Tyr Pro Ser 
    50                  55                  60                  


Ile Lys Val His Ile Glu Ser Leu Asp Val Ser Lys Thr Glu Thr Ile 
65                  70                  75                  80  


Ala Pro Phe Leu Lys Gly Leu Pro Glu Glu Phe Ser Ile Val Asp Val 
                85                  90                  95      


Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Leu Asp Pro Ile Gly Ser 
            100                 105                 110         


Val Asp Pro Lys Asp Val Asp Glu Met Phe Gln Thr Asn Val Leu Gly 
        115                 120                 125             


Met Ile Gln Leu Thr Gln Leu Val Val Gln Gln Met Lys Glu Arg Asn 
    130                 135                 140                 


Ser Gly Asp Ile Val Gln Leu Gly Ser Val Ala Gly Arg Asn Pro Tyr 
145                 150                 155                 160 


Pro Gly Gly Gly Ile Tyr Cys Ala Ser Lys Ala Ala Leu Arg Ser Phe 
                165                 170                 175     


Thr His Val Leu Arg Glu Glu Leu Ile Asn Thr Lys Ile Arg Val Ile 
            180                 185                 190         


Glu Ile Glu Pro Gly Asn Val Ala Thr Glu Glu Phe Ser Leu Thr Arg 
        195                 200                 205             


Phe Lys Gly Asp Lys Ser Lys Ala Glu Lys Val Tyr Glu Gly Thr Glu 
    210                 215                 220                 


Pro Leu Tyr Gly Thr Asp Ile Ala Glu Leu Ile Leu Phe Ala Val Ser 
225                 230                 235                 240 


Arg Pro Gln Asn Thr Val Ile Ala Glu Thr Leu Val Phe Ala Ser Asn 
                245                 250                 255     


Gln Ala Ser Ala Tyr His Ile Phe Arg Gly Ser Leu Asp Lys 
            260                 265                 270 


<210>  19
<211>  271
<212>  PRT
<213>  Aspergillus nidulans

<400>  19

Met Ala Ser Ala Met Ala Lys Arg Leu Glu Gly Lys Thr Ile Val Ile 
1               5                   10                  15      


Thr Gly Ala Ser Ser Gly Ile Gly Arg Ser Thr Ala Arg Glu Phe Ala 
            20                  25                  30          


Arg Thr Ala Pro Lys Asp Leu Lys Leu Ile Val Thr Ala Arg Arg Ile 
        35                  40                  45              


Asp Ala Leu Glu Glu Leu Ala Lys Glu Ile Lys Glu Glu Val Gly Glu 
    50                  55                  60                  


Gly Val Lys Thr Leu Pro Val Lys Leu Asp Val Ser Asn Pro Glu Glu 
65                  70                  75                  80  


Val Lys Asn Phe Val Pro Ser Leu Pro Ala Glu Phe Gln Asp Ile Asp 
                85                  90                  95      


Ile Leu Val Asn Asn Ala Gly Leu Val Lys Gly Val Ala Gln Ala Pro 
            100                 105                 110         


Asn Ile Asp Pro Glu Asp Ile Asn Ile Met Phe Ala Thr Asn Val Thr 
        115                 120                 125             


Gly Leu Ile Asn Leu Thr Gln Ala Val Leu Pro Ile Phe Lys Lys Arg 
    130                 135                 140                 


Ser Asp Gly Gly Arg Gly Asp Ile Ile Asn Ile Gly Ser Ile Ala Gly 
145                 150                 155                 160 


Arg Glu Pro Tyr Pro Gly Gly Ser Ile Tyr Cys Ser Thr Lys Ala Ala 
                165                 170                 175     


Val Lys Ser Phe Thr Glu Ala Leu Arg Lys Glu Leu Ile Ser Thr Arg 
            180                 185                 190         


Ile Arg Val Ile Glu Ile Asp Pro Gly Gln Val Glu Thr Glu Phe Ser 
        195                 200                 205             


Ile Val Arg Phe Tyr Gly Asp Lys Ser Lys Ala Asn Ala Val Tyr Ala 
    210                 215                 220                 


Asn Cys Glu Pro Leu Thr Pro Asp Asp Ile Ala Glu Val Ile Val Phe 
225                 230                 235                 240 


Ala Ala Gly Arg Arg Glu Asn Val Val Ile Ala Asp Thr Leu Ile Phe 
                245                 250                 255     


Pro Ser His Gln Ala Ser Pro Gly His Leu Tyr Lys Lys Pro Gln 
            260                 265                 270     


<210>  20
<211>  278
<212>  PRT
<213>  Aspergillus niger

<400>  20

Met Ala Thr Ala Met Ala Lys Arg Leu Glu Gly Lys Thr Ile Leu Val 
1               5                   10                  15      


Thr Gly Ala Ser Ser Gly Ile Gly Arg Ser Thr Ala Lys Glu Phe Ala 
            20                  25                  30          


Arg Thr Ser Pro Lys Asp Leu Lys Ile Ile Val Thr Ala Arg Arg Ile 
        35                  40                  45              


Asp Ser Leu Gln Glu Leu Ala Lys Glu Ile Lys Glu Glu Val Gly Glu 
    50                  55                  60                  


Gly Val Lys Val Leu Pro Val Gln Leu Asp Val Ser Asn Pro Glu Asp 
65                  70                  75                  80  


Ile Lys Lys Phe Val Pro Ser Leu Pro Glu Glu Phe Lys Glu Ile Asp 
                85                  90                  95      


Val Leu Val Asn Asn Ala Gly Leu Val Lys Gly Val Ala Lys Ala Pro 
            100                 105                 110         


Glu Ile Ala Pro Glu Asp Ile Asn Val Met Phe Ser Thr Asn Val Thr 
        115                 120                 125             


Gly Leu Ile Asn Met Thr Gln Ala Ile Leu Pro Ile Phe Lys Lys Arg 
    130                 135                 140                 


Ala Asp Gly Gly Arg Gly Asp Ile Ile Asn Ile Gly Ser Ile Ala Gly 
145                 150                 155                 160 


Arg Glu Ala Tyr Pro Gly Gly Ser Ile Tyr Cys Ala Thr Lys Ala Ala 
                165                 170                 175     


Ile Arg Ser Phe Thr Asp Ala Leu Arg Lys Glu Leu Ile Ala Thr Arg 
            180                 185                 190         


Ile Arg Ile Ile Glu Ile Asp Pro Gly Gln Val Glu Thr Glu Phe Ser 
        195                 200                 205             


Val Val Arg Phe Tyr Gly Asp Lys Ala Lys Ala Asp Ala Val Tyr Ala 
    210                 215                 220                 


Gly Cys Glu Pro Leu Thr Pro Asp Asp Ile Ala Glu Val Val Val Phe 
225                 230                 235                 240 


Ala Ala Gly Arg Arg Glu Asn Val Val Ile Ala Asp Thr Leu Ile Phe 
                245                 250                 255     


Pro Ser His Gln Val Ser Gln Thr Ser His Thr Gly Leu Asn Ser Ile 
            260                 265                 270         


Ala Asp Gly Thr Val Thr 
        275             


<210>  21
<211>  270
<212>  PRT
<213>  Neurospora crassa

<400>  21

Met Ser Ser Ala Val Ala Lys Arg Leu Ala Gly Lys Thr Ile Val Ile 
1               5                   10                  15      


Thr Gly Ala Ser Ser Gly Ile Gly Arg Ser Thr Ala Phe Glu Phe Ala 
            20                  25                  30          


Arg Thr Ala Pro Asn His Gly Leu Lys Leu Ile Leu Thr Ala Arg Arg 
        35                  40                  45              


Val Asp Ala Leu Glu Gln Ile Ala Lys Glu Ile Arg Gln Glu Val Gly 
    50                  55                  60                  


Glu Gly Val Gln Val Leu Pro Val Lys Leu Asp Val Ser Gln Pro Glu 
65                  70                  75                  80  


Glu Val Arg Gly Phe Val Gly Asn Leu Pro Glu Glu Trp Arg Asp Ile 
                85                  90                  95      


His Val Leu Val Asn Asn Ala Gly Leu Val Lys Gly Ala Pro Ser Ile 
            100                 105                 110         


Ala Glu Glu Asp Ile Asn Val Met Phe Ala Thr Asn Val Thr Gly Leu 
        115                 120                 125             


Ile Asn Met Thr Gln Ala Ile Leu Pro Ile Phe Lys Ala Arg Gly Ser 
    130                 135                 140                 


Glu Gly Gly Ser Gly Asp Ile Val Asn Ile Gly Ser Ile Ala Gly Arg 
145                 150                 155                 160 


Glu Pro Tyr Ala Gly Gly Ser Ile Tyr Cys Ala Thr Lys Ala Ala Val 
                165                 170                 175     


Arg Ser Phe Thr Asp Ala Leu Arg Lys Glu Leu Ile Ala Thr Arg Ile 
            180                 185                 190         


Arg Val Met Glu Ile Asp Pro Gly Gln Val Glu Thr Glu Phe Ser Val 
        195                 200                 205             


Val Arg Phe Tyr Gly Asp Lys Asn Lys Ala Asp Ala Val Tyr Ala Gly 
    210                 215                 220                 


Val Asp Pro Leu Thr Pro Asp Asp Ile Ala Glu Ile Val Val Phe Val 
225                 230                 235                 240 


Val Thr Arg Arg Glu Asn Val Val Val Ala Asp Thr Leu Val Phe Pro 
                245                 250                 255     


Ser His Gln Ala Gly Ala Gly Ile Met His Arg Lys Ser Thr 
            260                 265                 270 


<210>  22
<211>  259
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  22

Met Ser Arg Leu Asp Gly Lys Thr Ile Leu Ile Thr Gly Ala Ser Ser 
1               5                   10                  15      


Gly Ile Gly Lys Ser Thr Ala Phe Glu Ile Ala Lys Val Ala Lys Val 
            20                  25                  30          


Lys Leu Ile Leu Ala Ala Arg Arg Phe Ser Thr Val Glu Glu Ile Ala 
        35                  40                  45              


Lys Glu Leu Glu Ser Lys Tyr Glu Val Ser Val Leu Pro Leu Lys Leu 
    50                  55                  60                  


Asp Val Ser Asp Leu Lys Ser Ile Pro Gly Val Ile Glu Ser Leu Pro 
65                  70                  75                  80  


Lys Glu Phe Ala Asp Ile Asp Val Leu Ile Asn Asn Ala Gly Leu Ala 
                85                  90                  95      


Leu Gly Thr Asp Lys Val Ile Asp Leu Asn Ile Asp Asp Ala Val Thr 
            100                 105                 110         


Met Ile Thr Thr Asn Val Leu Gly Met Met Ala Met Thr Arg Ala Val 
        115                 120                 125             


Leu Pro Ile Phe Tyr Ser Lys Asn Lys Gly Asp Ile Leu Asn Val Gly 
    130                 135                 140                 


Ser Ile Ala Gly Arg Glu Ser Tyr Val Gly Gly Ser Val Tyr Cys Ser 
145                 150                 155                 160 


Thr Lys Ser Ala Leu Ala Gln Phe Thr Ser Ala Leu Arg Lys Glu Thr 
                165                 170                 175     


Ile Asp Thr Arg Ile Arg Ile Met Glu Val Asp Pro Gly Leu Val Glu 
            180                 185                 190         


Thr Glu Phe Ser Val Val Arg Phe His Gly Asp Lys Gln Lys Ala Asp 
        195                 200                 205             


Asn Val Tyr Lys Asn Ser Glu Pro Leu Thr Pro Glu Asp Ile Ala Glu 
    210                 215                 220                 


Val Ile Leu Phe Ala Leu Thr Arg Arg Glu Asn Val Val Ile Ala Asp 
225                 230                 235                 240 


Thr Leu Val Phe Pro Ser His Gln Gly Gly Ala Asn His Val Tyr Arg 
                245                 250                 255     


Lys Gln Ala 
            


<210>  23
<211>  268
<212>  PRT
<213>  Kluyveromyces marxianus

<400>  23

Met Ser Gln Gly Arg Arg Ala Ala Glu Arg Leu Gln Asn Lys Thr Ile 
1               5                   10                  15      


Phe Ile Thr Gly Ala Ser Ala Gly Ile Gly Glu Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Asp Ala Ala Asn Gly Asn Val Lys Leu Val Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Ser Lys Leu Gln Ala Leu Lys Asp Lys Ile Ala Ala Glu Tyr 
    50                  55                  60                  


Pro Glu Ala Lys Val Tyr Ile Gly Glu Leu Asp Val Thr Glu Thr Glu 
65                  70                  75                  80  


Lys Ile Lys Pro Phe Ile Gln Gly Leu Pro Glu Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Ile Asn Asn Ala Gly Lys Ala Leu Gly Val Asp Pro Val 
            100                 105                 110         


Gly Ala Ile Asp Ser Glu Asp Ile Lys Gly Met Ile Asp Thr Asn Val 
        115                 120                 125             


Leu Gly Leu Ile Asn Val Thr Gln Ala Val Leu Pro Ile Phe Lys Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Val Ala Gly Arg Glu 
145                 150                 155                 160 


Ala Tyr Pro Asn Gly Ser Ile Tyr Cys Ala Thr Lys His Ala Val Arg 
                165                 170                 175     


Ala Phe Thr Gln Ser Leu Arg Lys Glu Leu Ile Asn Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Glu Ile Ala Pro Gly Asn Val Glu Thr Glu Phe Ser Tyr Val 
        195                 200                 205             


Arg Tyr Lys Gly Asp Thr Asp Ala Ala Lys Lys Val Tyr Lys Gly Thr 
    210                 215                 220                 


Thr Pro Leu Tyr Ala Asp Asp Ile Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Thr Val Ile Ala Asp Val Leu Val Phe Ala Thr 
                245                 250                 255     


Asn Gln Ala Ser Pro Tyr His Ile Tyr Arg Gly Glu 
            260                 265             


<210>  24
<400>  24
000


<210>  25
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  26
<211>  499
<212>  PRT
<213>  Saccharomyces castellii

<400>  26

Met Thr Lys Ile Asn Phe Glu Ala Ala Glu Pro Ala Thr Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Ile Thr Tyr Asn Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Glu Phe Met Lys Ser Gln Asp Tyr Lys Thr Ile Lys Val Glu Asn Pro 
        35                  40                  45              


Ala Thr Ala Glu Ile Val Cys Glu Val Ser Ser Gly Thr Ser Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Val Glu Ser Ala Glu His Ala Phe Asn Asp Thr Asp 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Lys Ile Arg Gly Arg Tyr Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Leu Met Glu Glu Asn Leu Glu Leu Met Ala Ser Ile Glu Thr 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ser Arg Gly Asp Val Gly Leu 
        115                 120                 125             


Ala Ile Asn Cys Ile Arg Asp Ala Ala Ser Tyr Ala Asp Lys Ile Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Ser Gly Asp Gly Tyr Met Asn Phe Thr Val Lys 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu 
                165                 170                 175     


Met Met Leu Ser Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Ile Ile Leu Lys Pro Ala Ser Ala Thr Pro Leu Asn Ala Leu Phe Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Ile Pro Gly Pro Gly Arg Thr Val Gly Asn Ala Ile Thr Thr His Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Ala Ala Phe Thr Gly Ser Thr Glu Ile Gly Lys Asp 
                245                 250                 255     


Ile Ala Ile Lys Ala Ser Gly Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Glu 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Lys Leu Met Pro Ala Phe Lys Lys Tyr Val Glu Asn Leu Lys Val Gly 
                325                 330                 335     


Asp Pro Phe Asp Glu Ser Asn Phe Gln Gly Ala Ile Thr Asn Arg Glu 
            340                 345                 350         


Gln Tyr Glu Thr Ile Leu Lys Tyr Ile Lys Ile Gly Lys Glu Glu Gly 
        355                 360                 365             


Ala Lys Ile Leu Thr Gly Gly Glu Thr Ile Gly Asn Lys Gly Tyr Phe 
    370                 375                 380                 


Ile Lys Pro Thr Ile Phe Tyr Asp Val Lys Glu Asp Met Glu Ile Val 
385                 390                 395                 400 


Arg Glu Glu Ile Phe Gly Pro Val Val Thr Val Ser Lys Phe Lys Asp 
                405                 410                 415     


Ile Glu Asp Gly Val Ala Met Ala Asn Ala Ser Glu Phe Gly Leu Gly 
            420                 425                 430         


Ala Gly Ile Glu Thr Glu Asn Leu Ser Thr Ala Leu Lys Val Ala Lys 
        435                 440                 445             


Met Leu Lys Ser Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe Asp 
    450                 455                 460                 


Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg Glu 
465                 470                 475                 480 


Met Gly Glu Glu Val Tyr Asp Cys Tyr Thr Glu Val Lys Ala Ile Arg 
                485                 490                 495     


Ile Lys Leu 
            


<210>  27
<211>  497
<212>  PRT
<213>  Candida glabrata

<400>  27

Met Ala Tyr Lys Thr Ala Ala Thr Lys Thr Ile Lys Leu Pro Asn Gly 
1               5                   10                  15      


Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn Glu Phe Val 
            20                  25                  30          


Glu Ser Ser Asp Gly Lys Thr Met Thr Ile Glu Asn Pro Ser Thr Gln 
        35                  40                  45              


Glu Pro Ile Val Asp Val Phe Ser Ala Thr Lys Glu Asp Val Asp Tyr 
    50                  55                  60                  


Ala Val Asp Cys Ala Glu Arg Ala Phe Glu Lys Ser Asp Trp Ala Thr 
65                  70                  75                  80  


Gln Asp Pro Lys Val Arg Ala Arg Tyr Leu Ser Lys Leu Ala Asp Leu 
                85                  90                  95      


Met Glu Glu Gln Leu Glu Leu Ile Ala Ser Ile Glu Thr Leu Asp Asn 
            100                 105                 110         


Gly Lys Thr Ile Ala Leu Ser Arg Gly Asp Val Gln Leu Ser Ile Asn 
        115                 120                 125             


Cys Ile Arg Asp Ala Ala Ser Tyr Ala Asp Lys Val Asp Gly Arg Ser 
    130                 135                 140                 


Ile Asp Thr Gly Asp Gly Tyr Met Asn Tyr Thr Ile Arg Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Ala Gln Ile Ile Pro Trp Asn Phe Pro Leu Met Met Leu 
                165                 170                 175     


Ser Trp Lys Val Gly Pro Ala Leu Ala Met Gly Asn Cys Ile Val Leu 
            180                 185                 190         


Lys Pro Ala Ser Ala Thr Pro Leu Asn Ala Leu Tyr Phe Ser Ser Leu 
        195                 200                 205             


Cys Lys Gln Val Gly Ile Pro Ala Gly Val Val Asn Ile Ile Pro Gly 
    210                 215                 220                 


Pro Gly Gly Met Val Gly Thr Ala Leu Thr Thr His Pro Lys Val Arg 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Asp Ile Gly Lys Asp Ile Ala Val 
                245                 250                 255     


Lys Ala Ser Ala Ser Asn Leu Lys Lys Ile Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Ala His Leu Val Phe Asn Asp Ala Asn Leu Glu Lys Thr Leu 
        275                 280                 285             


Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln Ile Cys Ser 
    290                 295                 300                 


Ser Gly Ser Arg Ile Tyr Ala Gln Ala Gly Ile Tyr Asp Arg Leu Leu 
305                 310                 315                 320 


Lys Glu Phe Lys Ala Tyr Ile Glu Lys Asn Ile Lys Val Gly Asn Pro 
                325                 330                 335     


Phe Asp Glu Ser Asn Phe Gln Gly Ala Ile Thr Asn Lys Glu Gln Tyr 
            340                 345                 350         


Asn Thr Ile Leu Lys Tyr Ile Asn Ile Gly Lys Glu Glu Gly Ala Lys 
        355                 360                 365             


Val Leu Thr Gly Gly Glu Thr Ala Ala Glu Lys Gly Tyr Phe Ile Lys 
    370                 375                 380                 


Pro Thr Val Phe Tyr Asp Val Lys Glu Asp Met Arg Val Val Lys Glu 
385                 390                 395                 400 


Glu Ile Phe Gly Pro Cys Val Thr Ile Ser Lys Phe Glu Glu Ile Glu 
                405                 410                 415     


Asp Gly Val Ala Met Ala Asn Asp Ser Glu Phe Gly Leu Gly Ala Gly 
            420                 425                 430         


Ile Glu Thr Glu Asn Leu Ser Thr Ala Leu Lys Val Ala Lys Met Leu 
        435                 440                 445             


His Ser Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe Asp Ser Arg 
    450                 455                 460                 


Val Pro Phe Gly Gly Tyr Lys Gln Ser Gly Tyr Gly Arg Glu Met Gly 
465                 470                 475                 480 


Ser Glu Val Tyr Glu Cys Tyr Thr Gln Thr Lys Ala Val Arg Ile Lys 
                485                 490                 495     


Leu 
    


<210>  28
<211>  500
<212>  PRT
<213>  Saccharomyces bayanus

<400>  28

Met Thr Lys Leu His Phe Asp Thr Ala Glu Ala Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Thr Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Ile Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ser 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Ile Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Thr Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Ser Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Ile Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asp Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Glu Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Ala Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  29
<211>  507
<212>  PRT
<213>  Kluyveromyces lactis

<400>  29

Met Ser Ser Thr Ile Ala Glu Lys Leu Asn Leu Lys Ile Val Glu Gln 
1               5                   10                  15      


Asp Ala Val Ser Ile Thr Leu Pro Asn Gly Leu Thr Tyr Gln Gln Pro 
            20                  25                  30          


Thr Gly Leu Phe Ile Asn Asn Gln Phe Ile Lys Ser Gln Asp Gly Lys 
        35                  40                  45              


Thr Leu Lys Val Glu Asn Pro Ser Thr Glu Glu Ile Ile Val Glu Val 
    50                  55                  60                  


Gln Ser Ala Thr Ser Gln Asp Val Glu Tyr Ala Val Glu Ala Ala Asp 
65                  70                  75                  80  


Ala Ala Phe Asn Ser Glu Trp Ser Thr Met Asp Pro Lys Lys Arg Gly 
                85                  90                  95      


Ser Leu Leu Phe Lys Leu Ala Asp Leu Ile Glu Ala Gln Lys Glu Leu 
            100                 105                 110         


Ile Ala Ser Ile Glu Ser Ala Asp Asn Gly Lys Thr Leu Ala Leu Ala 
        115                 120                 125             


Arg Gly Asp Val Gly Leu Val Ile Asp Tyr Ile Arg Ser Ala Ala Gly 
    130                 135                 140                 


Tyr Ala Asp Lys Leu Gly Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr 
145                 150                 155                 160 


Ala Asn Phe Thr Tyr Lys Glu Pro Leu Gly Val Cys Gly Gln Ile Ile 
                165                 170                 175     


Pro Trp Asn Phe Pro Leu Met Met Leu Ser Trp Lys Ile Ala Pro Ala 
            180                 185                 190         


Leu Val Ala Gly Asn Thr Val Ile Leu Lys Pro Ala Ser Pro Thr Pro 
        195                 200                 205             


Leu Asn Ala Leu Phe Phe Ala Ser Leu Cys Lys Glu Ala Gly Ile Pro 
    210                 215                 220                 


Ala Gly Val Val Asn Ile Val Pro Gly Pro Gly Arg Ser Val Gly Asp 
225                 230                 235                 240 


Thr Ile Thr Asn His Pro Lys Ile Arg Lys Ile Ala Phe Thr Gly Ser 
                245                 250                 255     


Thr Asp Ile Gly Arg Asp Val Ala Ile Lys Ala Ala Gln Ser Asn Leu 
            260                 265                 270         


Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Ala His Leu Val Phe 
        275                 280                 285             


Glu Asp Ala Asn Ile Lys Lys Thr Ile Pro Asn Leu Val Asn Gly Ile 
    290                 295                 300                 


Phe Lys Asn Ala Gly Gln Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val 
305                 310                 315                 320 


Gln Asp Thr Ile Tyr Asp Gln Leu Leu Ser Glu Phe Lys Thr Tyr Leu 
                325                 330                 335     


Glu Thr Glu Ile Lys Val Gly Ser Pro Phe Asp Glu Ser Asn Phe Gln 
            340                 345                 350         


Ala Ala Ile Asn Asn Lys Ala Gln Phe Glu Thr Ile Leu Asn Tyr Ile 
        355                 360                 365             


Asp Ile Gly Lys Lys Glu Gly Ala Ser Ile Leu Thr Gly Gly Glu Arg 
    370                 375                 380                 


Val Gly Asn Lys Gly Tyr Phe Ile Lys Pro Thr Val Phe Tyr Asn Val 
385                 390                 395                 400 


Lys Glu Asp Met Arg Ile Val Lys Glu Glu Ile Phe Gly Pro Val Val 
                405                 410                 415     


Thr Ile Ser Lys Phe Ser Thr Val Asp Glu Ala Val Ala Leu Ala Asn 
            420                 425                 430         


Asp Ser Glu Phe Gly Leu Gly Ala Gly Ile Glu Thr Glu Asn Ile Ser 
        435                 440                 445             


Val Ala Leu Lys Val Ala Lys Arg Leu Lys Ala Gly Thr Val Trp Ile 
    450                 455                 460                 


Asn Thr Tyr Asn Asp Phe Asp Ala Ala Val Pro Phe Gly Gly Tyr Lys 
465                 470                 475                 480 


Gln Ser Gly Tyr Gly Arg Glu Met Gly Glu Glu Ala Phe Glu Ser Tyr 
                485                 490                 495     


Thr Gln Ile Lys Ala Val Arg Ile Lys Leu Asp 
            500                 505         


<210>  30
<211>  526
<212>  PRT
<213>  Kluyveromyces thermotolerans

<400>  30

Met Asn Tyr Ala Cys Leu Arg Ser Gly Ser Ser Met Leu Gly Met Val 
1               5                   10                  15      


Lys Ala Ala Arg Ser Phe Ser Ile Ser Ala Arg Ala Leu Ser Ala Arg 
            20                  25                  30          


Ala Lys Ala Asp Phe Val Lys Ile Thr Thr Pro Asn Gly His Thr Tyr 
        35                  40                  45              


Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn Glu Phe Leu Lys Ser Gln 
    50                  55                  60                  


Lys Gly Glu Thr Ile Thr Val Glu Asp Pro Ser Thr Glu Gln Lys Ile 
65                  70                  75                  80  


Val Glu Val Gln Ser Gly Thr Lys Glu Asp Val Glu Tyr Ala Val Glu 
                85                  90                  95      


Cys Ala Glu Lys Ala Phe Asn Ser Ser Trp Ser Thr Gly Asp Pro Arg 
            100                 105                 110         


Asn Arg Ala Arg Ser Leu Leu Lys Leu Ala Asp Leu Val Glu Glu Arg 
        115                 120                 125             


Lys Glu Leu Ile Ala Ser Ile Glu Ser Met Asp Asn Gly Lys Thr Leu 
    130                 135                 140                 


Ala Leu Ala Arg Gly Asp Val Gly Ile Val Ile Asn Phe Leu Arg Ser 
145                 150                 155                 160 


Ala Ala Gly Tyr Ala Asp Lys Leu Asp Gly Arg Ser Ile Asn Thr Gly 
                165                 170                 175     


Asp Gly Tyr Val Asn Tyr Thr Ile Arg Glu Pro Val Gly Val Cys Gly 
            180                 185                 190         


Gln Ile Ile Pro Trp Asn Phe Pro Leu Met Met Leu Ser Trp Lys Ile 
        195                 200                 205             


Ala Pro Ala Leu Ala Ala Gly Asn Thr Val Ile Leu Lys Pro Ala Ser 
    210                 215                 220                 


Pro Thr Pro Leu Asn Ala Leu Tyr Phe Ala Ser Leu Cys Lys Glu Ala 
225                 230                 235                 240 


Gly Ile Pro Ala Gly Val Val Asn Ile Ile Pro Gly Pro Gly Arg Gly 
                245                 250                 255     


Val Gly Glu Thr Leu Thr Thr His Pro Lys Ile Arg Lys Ile Ala Phe 
            260                 265                 270         


Thr Gly Ser Thr Gly Thr Gly Lys Gly Ile Ala Val Lys Ala Ala Gln 
        275                 280                 285             


Ser Asn Leu Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Ala His 
    290                 295                 300                 


Leu Val Phe Asn Asp Ala Asn Ile Glu Lys Thr Leu Pro Asn Leu Val 
305                 310                 315                 320 


Asn Gly Ile Phe Leu Asn Ala Gly Gln Ile Cys Ser Ser Gly Ser Arg 
                325                 330                 335     


Ile Tyr Val Gln Glu Gly Ile Tyr Asp Lys Leu Leu Pro Ala Phe Arg 
            340                 345                 350         


Lys Tyr Val Glu Glu Lys Ile Thr Val Gly Ser Pro Phe Asp Glu Asn 
        355                 360                 365             


Asn Phe Gln Gly Ala Ile Asn Asn Lys Ala Gln Phe Glu Thr Ile Met 
    370                 375                 380                 


Asn Tyr Val Gly Ile Gly Lys Ser Glu Gly Ala Lys Val Leu Thr Gly 
385                 390                 395                 400 


Gly Glu Lys Val Asn Asp Lys Gly Tyr Phe Ile Arg Pro Thr Ile Phe 
                405                 410                 415     


Tyr Asp Val Glu Glu Asp Met Arg Ile Val Lys Glu Glu Val Phe Gly 
            420                 425                 430         


Pro Val Val Thr Ile Ser Lys Phe Lys Glu Ile Glu Asp Gly Val Ala 
        435                 440                 445             


Met Ala Asn Asp Ser Glu Phe Gly Leu Gly Ala Gly Ile Gln Thr Glu 
    450                 455                 460                 


Asn Val Ser Thr Ala Leu Lys Val Ser Lys Met Leu Lys Ala Gly Ile 
465                 470                 475                 480 


Val Trp Val Asn Thr Tyr Asn Asp Phe Asp Ser Ser Val Pro Phe Gly 
                485                 490                 495     


Gly Cys Lys Gln Ser Gly Tyr Gly Arg Glu Met Gly Ile Glu Ala Phe 
            500                 505                 510         


Glu Ala Tyr Thr Ser Val Lys Ala Val Arg Ile Lys Leu Ala 
        515                 520                 525     


<210>  31
<211>  526
<212>  PRT
<213>  Kluyveromyces waltii

<400>  31

Met Asn Lys Met Ser Leu Lys Asn Ala Ser Thr Met Leu Arg Met Ala 
1               5                   10                  15      


Lys Tyr Ala Arg Asn Phe Ser Val Ser Ser Arg Ile Leu Ser Ala Lys 
            20                  25                  30          


Met Lys Ala Asp Phe Val Lys Val Thr Thr Pro Asn Gly Leu Thr Tyr 
        35                  40                  45              


Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn Glu Phe Val Lys Ser His 
    50                  55                  60                  


Asn Gly Ala Thr Ile Ala Val Glu Asp Pro Ala Thr Glu Lys Lys Ile 
65                  70                  75                  80  


Val Glu Val Gln Ser Gly Thr Lys Glu Asp Val Glu Tyr Ala Val Glu 
                85                  90                  95      


Cys Ala Glu Lys Ala Phe Asn Ser Ser Trp Ser Thr Gly Asp Pro Arg 
            100                 105                 110         


Val Arg Ala Arg Ala Leu Leu Lys Leu Ala Asp Leu Ile Glu Gln Arg 
        115                 120                 125             


Lys Glu Leu Ile Ser Ser Ile Glu Cys Met Asp Asn Gly Lys Ala Leu 
    130                 135                 140                 


Phe Leu Ala Lys Asn Asp Val Arg Ile Val Ile Asp Tyr Ile Arg Ser 
145                 150                 155                 160 


Ser Ala Gly Phe Ala Asp Lys Leu Asp Gly Arg Thr Ile Asn Thr Gly 
                165                 170                 175     


Asp Gly Tyr Val Asn Tyr Thr Leu Arg Glu Pro Val Gly Val Cys Gly 
            180                 185                 190         


Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Leu Ser Trp Lys Ile 
        195                 200                 205             


Ala Pro Ala Leu Ala Ala Gly Asn Thr Val Ile Leu Lys Pro Ala Ser 
    210                 215                 220                 


Pro Thr Pro Leu Asn Ala Leu Tyr Phe Ala Ser Leu Cys Lys Glu Ala 
225                 230                 235                 240 


Gly Ile Pro Ala Gly Val Val Asn Ile Ile Pro Gly Pro Gly Arg Asp 
                245                 250                 255     


Val Gly Glu Thr Leu Thr Thr His Pro Lys Ile Arg Lys Ile Ala Phe 
            260                 265                 270         


Thr Gly Ser Thr Gly Thr Gly Lys Gly Ile Ala Val Lys Ala Ala Gln 
        275                 280                 285             


Ser Asn Leu Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Ala His 
    290                 295                 300                 


Met Val Phe Asn Asp Ala Asn Leu Glu Lys Thr Ile Pro Asn Leu Val 
305                 310                 315                 320 


Asn Gly Ile Phe Leu Asn Ala Gly Gln Ile Cys Ser Ser Gly Ser Arg 
                325                 330                 335     


Ile Tyr Val Gln Glu Gly Ile Tyr Asp Lys Leu Leu Pro Ala Phe Lys 
            340                 345                 350         


Lys Tyr Val Glu Glu Val Ile Thr Val Gly Ser Pro Phe Asp Glu Ser 
        355                 360                 365             


Asn Phe Gln Gly Ala Ile Asn Asn Lys Ala Gln Phe Asp Thr Ile Met 
    370                 375                 380                 


Asn Tyr Val Gly Ile Gly Lys Glu Glu Gly Ala Lys Val Leu Thr Gly 
385                 390                 395                 400 


Gly Lys Arg Ser Gly Asp Gln Gly Tyr Phe Ile Arg Pro Thr Ile Phe 
                405                 410                 415     


Tyr Asp Val Asn Glu Asp Met Arg Ile Val Lys Glu Glu Ile Phe Gly 
            420                 425                 430         


Pro Val Val Thr Ile Ser Lys Phe Lys Glu Ile Glu Asp Gly Val Ala 
        435                 440                 445             


Met Ala Asn Asn Ser Glu Phe Gly Leu Gly Ala Gly Ile Gln Thr Glu 
    450                 455                 460                 


Ser Val Ser Thr Ala Leu Lys Val Ser Lys Met Leu Lys Ala Gly Thr 
465                 470                 475                 480 


Val Trp Val Asn Thr Tyr Asn Asp Phe Asp Ser Ser Val Pro Phe Gly 
                485                 490                 495     


Gly Cys Lys Gln Ser Gly Tyr Gly Ser Glu Met Gly Ile Glu Ala Phe 
            500                 505                 510         


Asp Ser Tyr Thr Thr Thr Lys Ala Val Arg Ile Lys Leu Ala 
        515                 520                 525     


<210>  32
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  32

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  33
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  34
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  34

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  35
<211>  501
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Phe Lys Ala Arg Gly Asp Val Thr 
        115                 120                 125             


Ile Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val 
    130                 135                 140                 


Asn Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr 
145                 150                 155                 160 


Leu Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro 
                165                 170                 175     


Ile Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn 
            180                 185                 190         


Val Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr 
        195                 200                 205             


Phe Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn 
    210                 215                 220                 


Ile Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp 
225                 230                 235                 240 


Pro Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys 
                245                 250                 255     


Ser Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu 
            260                 265                 270         


Glu Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile 
        275                 280                 285             


Lys Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly 
    290                 295                 300                 


Gln Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr 
305                 310                 315                 320 


Asp Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys 
                325                 330                 335     


Val Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn 
            340                 345                 350         


Arg Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys 
        355                 360                 365             


Glu Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly 
    370                 375                 380                 


Tyr Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg 
385                 390                 395                 400 


Ile Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe 
                405                 410                 415     


Lys Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly 
            420                 425                 430         


Leu Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val 
        435                 440                 445             


Ala Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp 
    450                 455                 460                 


Phe Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly 
465                 470                 475                 480 


Arg Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala 
                485                 490                 495     


Val Arg Ile Lys Leu 
            500     


<210>  36
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  36

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Thr Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Val Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  37
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  37

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Pro Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  38
<211>  497
<212>  PRT
<213>  Pichia pastoris

<400>  38

Met Ser Glu Phe Val Ala Lys Ile Asn Ile Pro Thr Ile Ala Glu Pro 
1               5                   10                  15      


Val Glu Val Pro Thr Gly Leu Phe Ile Asn Asn Glu Trp Val Ala Ala 
            20                  25                  30          


Lys Ser Gly Lys Thr Phe Ala Val Thr Ser Pro Ile Asp Glu Ser His 
        35                  40                  45              


Leu Thr Asp Leu Gln Met Ala Gly Ala Asp Asp Val Asp Ile Ala Thr 
    50                  55                  60                  


Asp Phe Ala Tyr Lys Ala Phe Tyr Lys His Lys Phe Val Glu Pro Ser 
65                  70                  75                  80  


Val Arg Gly Arg Trp Leu Tyr Lys Leu Ala Glu Leu Phe Glu Glu His 
                85                  90                  95      


Lys Asp Thr Ile Ala Lys Leu Glu Ser Leu Asp Asn Gly Lys Ala Leu 
            100                 105                 110         


His Cys Ala Gln Phe Asp Leu Asn Leu Val Val Glu Tyr Leu Arg Ser 
        115                 120                 125             


Cys Ala Gly Tyr Ala Asp Lys Val Asp Gly Arg Thr Ile Asn Thr Gly 
    130                 135                 140                 


Lys Asp His Leu Asn Phe Thr Lys Arg Glu Pro Leu Gly Val Cys Gly 
145                 150                 155                 160 


Gln Ile Ile Pro Trp Asn Phe Pro Ile Leu Met Trp Ala Trp Lys Ile 
                165                 170                 175     


Gly Pro Ala Leu Ala Thr Gly Asn Ala Val Val Leu Lys Pro Ala Ser 
            180                 185                 190         


Ala Thr Pro Leu Thr Ala Leu Tyr Ala Thr Lys Leu Val Lys Glu Ala 
        195                 200                 205             


Gly Ile Pro Ala Gly Leu Val Asn Ile Val Pro Gly Ser Gly Arg Gly 
    210                 215                 220                 


Cys Gly Asn Ala Ile Leu Gln His Pro Lys Ile Lys Lys Ile Ala Phe 
225                 230                 235                 240 


Thr Gly Ser Thr Ala Val Gly Ile Asp Val Met Val Ala Ala Ala Thr 
                245                 250                 255     


Phe Asn Leu Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn 
            260                 265                 270         


Ile Val Phe Asp Asp Cys Glu Leu Glu Ser Thr Ile Gln Asn Leu Ile 
        275                 280                 285             


Thr Gly Ile Phe Phe Asn Gly Gly Glu Val Cys Cys Ala Gly Ser Arg 
    290                 295                 300                 


Ile Tyr Val Gln Glu Gly Ile Tyr Glu Gln Val Leu Ser Lys Phe Lys 
305                 310                 315                 320 


Glu Glu Ile Ser Lys Leu Lys Val Gly Asn Pro Phe Glu Glu Gly Thr 
                325                 330                 335     


Tyr Gln Gly Ala Gln Ala Thr Pro Asp Gln Phe Glu Cys Val Leu Gly 
            340                 345                 350         


Tyr Ile Glu Arg Ala Lys Lys Ala Gly Ala Lys Leu Leu Thr Gly Gly 
        355                 360                 365             


Asn Arg Ile Gly Thr Lys Gly Tyr Phe Val Glu Pro Thr Val Phe Tyr 
    370                 375                 380                 


Asp Cys Asp Glu Asp Leu Glu Ile Val Lys Asp Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Ala Ser Ile Gly Lys Phe Lys Asp Val Ala Glu Leu Val Glu Lys 
                405                 410                 415     


Ala Asn Asn Ser Glu Tyr Gly Leu Ala Ala Gly Ile His Thr Gln Asp 
            420                 425                 430         


Leu Asn Lys Ala Phe Gly Val Ala Asp Gln Leu Glu Ala Gly Ser Val 
        435                 440                 445             


Trp Ile Asn Thr Tyr Asn Asp Leu His Gln Ser Val Pro Phe Gly Gly 
    450                 455                 460                 


Tyr Lys Thr Ser Gly Ile Gly Arg Glu Met Gly Leu Glu Ala Phe Asp 
465                 470                 475                 480 


Asn Tyr Thr Gln Val Lys Ala Val Arg Thr Arg Leu Asn Val Pro Thr 
                485                 490                 495     


Ala 
    


<210>  39
<211>  507
<212>  PRT
<213>  Kluyveromyces marxianus

<400>  39

Met Ser Ser Ser Leu Ala Glu Lys Leu Asn Val Lys Ile Val Glu Gln 
1               5                   10                  15      


Lys Pro Val Thr Val Thr Leu Pro Asn Gly Leu Thr Tyr Glu Gln Pro 
            20                  25                  30          


Thr Gly Leu Phe Ile Asn Asn Gln Phe Ile Arg Ser Gln Asp Gly Ser 
        35                  40                  45              


Thr Leu Lys Val Glu Asn Pro Ser Thr Glu Glu Ile Ile Val Glu Val 
    50                  55                  60                  


Gln Ser Ala Thr Ala Gln Asp Val Glu Tyr Ala Val Glu Ser Ala Glu 
65                  70                  75                  80  


Ala Ala Phe Asn Ser Glu Trp Ser Ser Met Asp Pro Arg Asn Arg Ala 
                85                  90                  95      


Ala Tyr Leu Val Lys Leu Ala Asn Leu Ile Glu Glu Lys Lys Glu Leu 
            100                 105                 110         


Ile Ala Ser Ile Glu Ser Thr Asp Asn Gly Lys Ala Leu Ala Leu Ala 
        115                 120                 125             


Arg Gly Asp Val Gly Leu Val Ile Asp Tyr Ile Arg Ser Ala Ala Gly 
    130                 135                 140                 


Tyr Ala Asp Lys Leu Gly Gly Arg Thr Ile Asp Thr Gly Asp Gly Tyr 
145                 150                 155                 160 


Ala Asn Phe Thr Tyr Arg Glu Pro Ile Gly Val Cys Gly Gln Ile Ile 
                165                 170                 175     


Pro Trp Asn Phe Pro Leu Met Met Leu Ser Trp Lys Ile Ala Pro Ala 
            180                 185                 190         


Leu Val Ala Gly Asn Thr Val Ile Leu Lys Pro Ala Ser Pro Thr Pro 
        195                 200                 205             


Leu Asn Ala Leu Phe Phe Ala Ser Leu Cys Lys Glu Ala Gly Ile Pro 
    210                 215                 220                 


Ala Gly Val Val Asn Ile Val Pro Gly Pro Gly Arg Ser Val Gly Asp 
225                 230                 235                 240 


Thr Ile Thr Asn His Pro Lys Ile Arg Lys Ile Ala Phe Thr Gly Ser 
                245                 250                 255     


Thr Asp Ile Gly Arg Asp Val Ala Ile Lys Ala Ala Gln Ser Asn Leu 
            260                 265                 270         


Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Ala His Leu Val Phe 
        275                 280                 285             


Ala Asp Ala Asn Ile Lys Lys Thr Ile Pro Asn Leu Val Asn Gly Ile 
    290                 295                 300                 


Phe Lys Asn Ala Gly Gln Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val 
305                 310                 315                 320 


Gln Asp Thr Ile Tyr Asp Glu Leu Leu Ser Glu Phe Lys Lys Tyr Leu 
                325                 330                 335     


Glu Thr Glu Ile Lys Val Gly Ser Pro Phe Asp Glu Ser Asn Phe Gln 
            340                 345                 350         


Ala Ala Ile Thr Asn Lys Ala Gln Phe Glu Thr Ile Leu Asn Tyr Ile 
        355                 360                 365             


Asp Ile Gly Lys Lys Glu Gly Ala Lys Ile Leu Thr Gly Gly Glu Arg 
    370                 375                 380                 


Val Gly Asn Lys Gly Tyr Phe Ile Arg Pro Thr Val Phe Tyr Asp Val 
385                 390                 395                 400 


Lys Glu Asp Met Arg Ile Val Lys Glu Glu Ile Phe Gly Pro Val Val 
                405                 410                 415     


Thr Ile Ser Lys Phe Ser Thr Val Asp Glu Ala Val Ala Leu Ala Asn 
            420                 425                 430         


Asp Ser Glu Phe Gly Leu Gly Ala Gly Ile Glu Thr Glu Asn Leu Ser 
        435                 440                 445             


Val Ala Leu Lys Val Ala Lys Arg Leu His Ala Gly Thr Val Trp Ile 
    450                 455                 460                 


Asn Thr Tyr Asn Asp Phe Asp Ala Ala Val Pro Phe Gly Gly Tyr Lys 
465                 470                 475                 480 


Gln Ser Gly Tyr Gly Arg Glu Met Gly Glu Glu Ala Phe Glu Ser Tyr 
                485                 490                 495     


Thr Gln Val Lys Ala Val Arg Ile Lys Leu Glu 
            500                 505         


<210>  40
<211>  503
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  40

Met Ser Thr Lys Leu Val Asp His Val Glu Ile Thr Val Pro Thr Gly 
1               5                   10                  15      


Lys Thr Tyr Ile Gln Pro Val Gly Leu Phe Ile Asn Asn Gln His Val 
            20                  25                  30          


Asp Ser Val His Gly Gly Arg Val Lys Val Tyr Ser Pro Ser Thr Glu 
        35                  40                  45              


Lys Leu Ile Cys Glu Val Ala Asp Ala Asp Glu Glu Asp Val Asp Ile 
    50                  55                  60                  


Ala Val Lys Val Ala Arg Ala Ala Phe Gln Thr Asp Ala Pro Trp Arg 
65                  70                  75                  80  


Lys Phe Ser Ser Ala Gln Arg Gly Arg Cys Leu Ser Arg Leu Ala Asp 
                85                  90                  95      


Cys Ile Glu Gln Asn Leu Glu Tyr Leu Ala Ser Ile Glu Thr Leu Asp 
            100                 105                 110         


Asn Gly Lys Ser Ile Thr Leu Ala Arg Gly Asp Val Gln Ala Ala Ala 
        115                 120                 125             


Asp Cys Phe Arg Tyr Tyr Gly Gly Trp Ala Asp Lys Asp Tyr Gly Gln 
    130                 135                 140                 


Thr Ile Glu Thr Asp Ile Lys Arg Phe Ala Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Phe Leu Met 
                165                 170                 175     


Cys Ala Trp Lys Ile Ala Pro Ala Val Ala Cys Gly Asn Thr Ile Ile 
            180                 185                 190         


Leu Lys Thr Ala Glu Leu Thr Pro Leu Ser Ala Leu Cys Leu Thr Lys 
        195                 200                 205             


Phe Val Pro Glu Cys Gly Phe Pro Pro Gly Val Ile Asn Val Leu Ser 
    210                 215                 220                 


Gly Asp Gly Arg Arg Cys Gly Asn Ala Ile Ser Ser His Met Asp Ile 
225                 230                 235                 240 


Asp Lys Val Ala Phe Thr Gly Ser Thr Gly Val Gly Arg Met Val Met 
                245                 250                 255     


Arg Ala Ala Ala Ser Ser Asn Leu Lys Lys Val Thr Leu Glu Leu Gly 
            260                 265                 270         


Gly Lys Ser Pro Asn Ile Val Phe Asn Asp Ala Asp Leu Asp Ser Ala 
        275                 280                 285             


Ala Val Trp Thr Asn Tyr Gly Ile Phe Tyr Asn Ser Gly Gln Val Cys 
    290                 295                 300                 


Cys Ala Gly Ser Arg Val Tyr Val Gln Glu Asp Val Tyr Asp Glu Phe 
305                 310                 315                 320 


Ile Lys Arg Met Val Ala Lys Ala Lys Thr Leu Lys Val Gly Asp Pro 
                325                 330                 335     


Phe Ala Glu Asp Thr Phe Gln Gly Ala Gln Val Ser Lys Gln Gln Tyr 
            340                 345                 350         


Glu Arg Ile Val Ser Tyr Ile Glu Ser Gly Ile Ala His Gly Ala Lys 
        355                 360                 365             


Leu Glu Ile Gly Gly Lys Arg His Gly Asn Leu Gly Tyr Phe Val Glu 
    370                 375                 380                 


Pro Thr Ile Leu Ser Asn Val Thr Glu Asp Met Ala Val Gly Lys Glu 
385                 390                 395                 400 


Glu Ile Phe Gly Pro Val Leu Ala Val Ile Lys Phe Lys Thr Ile Glu 
                405                 410                 415     


Glu Ala Ile Arg Arg Gly Asn Asn Ser Thr Tyr Gly Leu Ala Ala Gly 
            420                 425                 430         


Val His Thr Asn Asn Ile Thr Asn Ala Ile Lys Val Ser Asn Ala Leu 
        435                 440                 445             


Glu Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Leu Leu His His Gln 
    450                 455                 460                 


Ile Pro Phe Gly Gly Tyr Lys Glu Ser Gly Ile Gly Arg Glu Leu Gly 
465                 470                 475                 480 


Ser Tyr Gly Leu Thr Asn Tyr Thr Gln Thr Lys Ala Val His Ile Asn 
                485                 490                 495     


Leu Gly Met Asp Ser Pro Ile 
            500             


<210>  41
<211>  496
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  41

Met Ser Glu Asp Leu Phe Val Ser Ile Asn Phe Pro Asn Gly Lys Ser 
1               5                   10                  15      


Val Lys Gln Pro Ile Gly Leu Tyr Ile Asn Gly Glu Trp His Lys Ser 
            20                  25                  30          


Ala Glu Thr Trp Glu Thr Val Asp Pro Ser Ile Glu Glu Val Ile Ala 
        35                  40                  45              


Lys Val Tyr Leu Ala Gly Glu Lys Glu Ile Asp Tyr Ala Val Lys Ser 
    50                  55                  60                  


Ala Lys Glu Ala Phe Lys Thr Trp Lys Lys Val Pro Gly Ser Glu Lys 
65                  70                  75                  80  


Gly Glu Leu Leu Met Lys Leu Ala Glu Leu Thr Glu Lys His Ala Asp 
                85                  90                  95      


Thr Leu Ala Ala Ile Glu Ala Met Asp Ser Gly Lys Pro Leu Val Ser 
            100                 105                 110         


Asn Ala Arg Gly Asp Val Asp Gly Thr Ile Ala Leu Leu Arg Tyr Cys 
        115                 120                 125             


Ala Gly Trp Ala Asp Lys Ile Tyr Gly Gln Val Ile Pro Thr Gly Pro 
    130                 135                 140                 


Glu Lys Leu Ala Tyr Ala Lys Arg Thr Pro Ile Gly Val Cys Gly Gln 
145                 150                 155                 160 


Ile Val Pro Trp Asn Tyr Pro Leu Asn Met Ala Gly Trp Lys Ile Ala 
                165                 170                 175     


Pro Ala Leu Ala Ala Gly Asn Cys Ile Ile Ile Lys Ser Ala Glu Thr 
            180                 185                 190         


Thr Pro Leu Ser Leu Leu Tyr Phe Ala Thr Leu Val Glu Glu Ala Gly 
        195                 200                 205             


Phe Pro Lys Gly Val Val Asn Ile Ile Ser Gly Leu Gly Thr Val Ala 
    210                 215                 220                 


Gly Ser Tyr Met Ala Lys His Pro Gly Ile Asp Lys Ile Ala Phe Thr 
225                 230                 235                 240 


Gly Ser Thr Lys Val Gly Val Ile Val Gln Gln Leu Ala Ala Ser Asn 
                245                 250                 255     


Leu Lys Ala Val Thr Leu Glu Cys Gly Gly Lys Ser Pro Phe Leu Val 
            260                 265                 270         


Phe Glu Asp Ala Asp Leu Asp Gln Ala Val Lys Trp Ala Ala Leu Gly 
        275                 280                 285             


Ile Met Tyr Asn Ser Gly Gln Ile Cys Thr Ser Asn Ser Arg Ile Tyr 
    290                 295                 300                 


Val Gln Asp Ser Val Tyr Asp Lys Phe Ile Glu Leu Phe Lys Lys His 
305                 310                 315                 320 


Val Ile Gln Asp Tyr Ile Val Gly Met Pro Phe Asp Asp Asn Thr Val 
                325                 330                 335     


Val Gly Pro Val Val Asn Lys Thr Gln Tyr Asn Arg Ile Lys Asn Tyr 
            340                 345                 350         


Ile Glu Gln Gly Lys Lys Glu Gly Ala Lys Leu Val Leu Gly Asp Glu 
        355                 360                 365             


Pro Leu Pro Leu Lys Gln Gly Tyr Phe Ile Ser Pro Thr Ile Phe Ala 
    370                 375                 380                 


Asp Cys Ser Glu Asn Met Thr Ile Val Lys Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Val Ala Ile Ser Lys Phe Lys Thr Glu Asp Glu Ala Ile Glu Lys 
                405                 410                 415     


Ala Asn Asn Thr Thr Tyr Gly Leu Ala Ala Met Cys Phe Thr Lys Asp 
            420                 425                 430         


Leu Glu Arg Ala His Arg Val Ser Asp Glu Leu Glu Ala Gly Met Val 
        435                 440                 445             


Phe Ile Asn Ser Thr Glu Asn Ser Asp Ile Gln Ala Pro Phe Gly Gly 
    450                 455                 460                 


Ile Lys Met Ser Gly Ile Gly Asn Glu Leu Gly Ser Asn Gly Ile Glu 
465                 470                 475                 480 


Met Tyr Thr Gln Ile Lys Ala Val His Ile Asn Phe Asn Asn Lys Leu 
                485                 490                 495     


<210>  42
<211>  1716
<212>  DNA
<213>  Bacillus subtilis

<400>  42
atgttgacta aagctacaaa agagcagaaa tcattggtga aaaatagggg tgcagaactt       60

gttgtggact gtttggtaga acagggcgta acacatgttt ttggtatccc aggtgcaaaa      120

atcgacgccg tgtttgatgc attacaagac aagggtccag aaattattgt tgctagacat      180

gagcaaaatg ccgcatttat ggcgcaagct gtaggtaggc ttacaggtaa acctggtgtt      240

gtcctagtta cgtctggccc aggagcctcc aatttagcaa ctggtctatt gacagctaat      300

actgagggag atcctgtagt tgcgttagcc ggtaatgtaa ttagagctga taggcttaag      360

agaactcacc agtctctaga caacgctgct ttattccaac cgatcaccaa gtactcagta      420

gaggtacaag acgtaaagaa tatacctgaa gctgtgacaa acgcatttcg tatagcttct      480

gctggtcagg ctggtgccgc gtttgtttct tttcctcaag acgttgtcaa tgaagtgacc      540

aatactaaaa acgttagagc ggttgcagcc cctaaactag gtccagccgc agacgacgca      600

attagcgctg caattgctaa aattcagacg gcgaaactac cagtagtcct tgtcggtatg      660

aagggcggaa gaccagaagc aataaaagct gttcgtaagt tattgaagaa agtccaatta      720

cctttcgttg agacttacca agcagcaggt actttatcta gagatttaga ggatcagtat      780

tttggaagga taggtctatt tagaaaccaa ccaggagatt tactattaga acaagctgat      840

gttgtactta ctatcggtta tgatcctata gagtatgacc caaagttttg gaacataaat      900

ggggatagaa caattataca tctagacgag ataatcgccg acatcgatca cgcttatcaa      960

ccagatttag aactaatcgg agatatcccg tcaacaatca atcatattga acatgatgct     1020

gtaaaggttg agttcgctga acgtgagcag aaaatcttat ctgatctaaa gcaatatatg     1080

catgagggtg aacaagttcc agcagactgg aaatctgacc gtgcacatcc tttggaaatc     1140

gttaaggaac taagaaatgc ggtcgatgat catgtgactg ttacatgtga tatcggttca     1200

catgcaattt ggatgtcacg ttattttagg agctacgaac cattaacttt aatgatatct     1260

aacgggatgc aaactctggg ggttgcactt ccttgggcta ttggcgctag tttagttaag     1320

cccggtgaga aggtggtatc ggtatcaggt gatggtggct ttctgttttc ggctatggaa     1380

ttagaaactg cagtccgttt aaaagctccc attgtgcata ttgtctggaa tgattctact     1440

tacgacatgg ttgcttttca acagttgaag aaatacaata gaacttcggc tgtagacttt     1500

ggtaacatcg atattgtgaa atatgctgag tcttttggcg caacaggcct gagggtggaa     1560

agtccagatc agttagctga tgtgttgaga caagggatga atgccgaggg accggtaatc     1620

atagatgtgc cagttgacta ctcagacaat attaatttgg cttctgataa acttcctaaa     1680

gagtttggcg agctaatgaa gaccaaagcc ttataa                               1716


<210>  43
<211>  571
<212>  PRT
<213>  Bacillus subtilis

<400>  43

Met Leu Thr Lys Ala Thr Lys Glu Gln Lys Ser Leu Val Lys Asn Arg 
1               5                   10                  15      


Gly Ala Glu Leu Val Val Asp Cys Leu Val Glu Gln Gly Val Thr His 
            20                  25                  30          


Val Phe Gly Ile Pro Gly Ala Lys Ile Asp Ala Val Phe Asp Ala Leu 
        35                  40                  45              


Gln Asp Lys Gly Pro Glu Ile Ile Val Ala Arg His Glu Gln Asn Ala 
    50                  55                  60                  


Ala Phe Met Ala Gln Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val 
65                  70                  75                  80  


Val Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu 
                85                  90                  95      


Leu Thr Ala Asn Thr Glu Gly Asp Pro Val Val Ala Leu Ala Gly Asn 
            100                 105                 110         


Val Ile Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Leu Asp Asn 
        115                 120                 125             


Ala Ala Leu Phe Gln Pro Ile Thr Lys Tyr Ser Val Glu Val Gln Asp 
    130                 135                 140                 


Val Lys Asn Ile Pro Glu Ala Val Thr Asn Ala Phe Arg Ile Ala Ser 
145                 150                 155                 160 


Ala Gly Gln Ala Gly Ala Ala Phe Val Ser Phe Pro Gln Asp Val Val 
                165                 170                 175     


Asn Glu Val Thr Asn Thr Lys Asn Val Arg Ala Val Ala Ala Pro Lys 
            180                 185                 190         


Leu Gly Pro Ala Ala Asp Asp Ala Ile Ser Ala Ala Ile Ala Lys Ile 
        195                 200                 205             


Gln Thr Ala Lys Leu Pro Val Val Leu Val Gly Met Lys Gly Gly Arg 
    210                 215                 220                 


Pro Glu Ala Ile Lys Ala Val Arg Lys Leu Leu Lys Lys Val Gln Leu 
225                 230                 235                 240 


Pro Phe Val Glu Thr Tyr Gln Ala Ala Gly Thr Leu Ser Arg Asp Leu 
                245                 250                 255     


Glu Asp Gln Tyr Phe Gly Arg Ile Gly Leu Phe Arg Asn Gln Pro Gly 
            260                 265                 270         


Asp Leu Leu Leu Glu Gln Ala Asp Val Val Leu Thr Ile Gly Tyr Asp 
        275                 280                 285             


Pro Ile Glu Tyr Asp Pro Lys Phe Trp Asn Ile Asn Gly Asp Arg Thr 
    290                 295                 300                 


Ile Ile His Leu Asp Glu Ile Ile Ala Asp Ile Asp His Ala Tyr Gln 
305                 310                 315                 320 


Pro Asp Leu Glu Leu Ile Gly Asp Ile Pro Ser Thr Ile Asn His Ile 
                325                 330                 335     


Glu His Asp Ala Val Lys Val Glu Phe Ala Glu Arg Glu Gln Lys Ile 
            340                 345                 350         


Leu Ser Asp Leu Lys Gln Tyr Met His Glu Gly Glu Gln Val Pro Ala 
        355                 360                 365             


Asp Trp Lys Ser Asp Arg Ala His Pro Leu Glu Ile Val Lys Glu Leu 
    370                 375                 380                 


Arg Asn Ala Val Asp Asp His Val Thr Val Thr Cys Asp Ile Gly Ser 
385                 390                 395                 400 


His Ala Ile Trp Met Ser Arg Tyr Phe Arg Ser Tyr Glu Pro Leu Thr 
                405                 410                 415     


Leu Met Ile Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu Pro Trp 
            420                 425                 430         


Ala Ile Gly Ala Ser Leu Val Lys Pro Gly Glu Lys Val Val Ser Val 
        435                 440                 445             


Ser Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala 
    450                 455                 460                 


Val Arg Leu Lys Ala Pro Ile Val His Ile Val Trp Asn Asp Ser Thr 
465                 470                 475                 480 


Tyr Asp Met Val Ala Phe Gln Gln Leu Lys Lys Tyr Asn Arg Thr Ser 
                485                 490                 495     


Ala Val Asp Phe Gly Asn Ile Asp Ile Val Lys Tyr Ala Glu Ser Phe 
            500                 505                 510         


Gly Ala Thr Gly Leu Arg Val Glu Ser Pro Asp Gln Leu Ala Asp Val 
        515                 520                 525             


Leu Arg Gln Gly Met Asn Ala Glu Gly Pro Val Ile Ile Asp Val Pro 
    530                 535                 540                 


Val Asp Tyr Ser Asp Asn Ile Asn Leu Ala Ser Asp Lys Leu Pro Lys 
545                 550                 555                 560 


Glu Phe Gly Glu Leu Met Lys Thr Lys Ala Leu 
                565                 570     


<210>  44
<211>  1476
<212>  DNA
<213>  Escherichia coli

<400>  44
atggcgaatt atttcaacac tctgaacctg cgtcaacaac tggcgcaact gggtaagtgc       60

cgtttcatgg gtcgtgacga gtttgcggac ggtgcttctt atctgcaagg caagaaggtt      120

gttattgttg gttgcggtgc gcaaggcctg aatcaaggtc tgaatatgcg cgacagcggc      180

ctggacatta gctatgcgct gcgcaaggag gctatcgcgg aaaaacgtgc tagctggcgc      240

aaggctactg agaacggctt caaggttggc acctatgagg agctgattcc gcaagctgac      300

ctggttatca atctgacccc agataaagtg catagcgacg ttgttcgtac tgttcaaccg      360

ctgatgaagg atggtgctgc tctgggttat agccacggct ttaacattgt tgaggtaggt      420

gaacaaattc gcaaggacat tactgttgtt atggtggctc caaagtgtcc gggtactgag      480

gttcgcgagg aatataagcg cggttttggt gttccaaccc tgatcgcggt gcatccagag      540

aatgacccaa agggtgaggg tatggctatc gcgaaggcgt gggctgcggc gactggcggc      600

catcgcgctg gcgttctgga gagcagcttt gtggctgagg ttaagagcga tctgatgggt      660

gaacagacta ttctgtgtgg tatgctgcaa gcgggtagcc tgctgtgttt tgataaactg      720

gttgaggagg gcactgaccc ggcgtatgcg gagaagctga tccaatttgg ctgggagact      780

attactgagg cgctgaagca aggtggtatt actctgatga tggatcgcct gagcaatcca      840

gctaagctgc gcgcgtacgc tctgagcgag caactgaagg aaattatggc accgctgttt      900

caaaagcaca tggatgatat cattagcggt gagtttagca gcggcatgat ggctgattgg      960

gcgaatgacg acaaaaagct gctgacttgg cgcgaggaaa ctggtaagac tgctttcgag     1020

actgctccac aatacgaggg taagattggt gaacaagaat attttgacaa gggtgttctg     1080

atgatcgcta tggttaaggc tggtgtggag ctggcttttg agactatggt tgacagcggt     1140

attatcgagg aaagcgcgta ctacgagagc ctgcatgaac tgccactgat cgcgaatact     1200

attgcgcgca aacgcctgta tgagatgaat gttgtgatta gcgacactgc ggaatatggc     1260

aattacctgt ttagctatgc gtgcgttcca ctgctgaagc cattcatggc ggaactgcag     1320

ccaggtgatc tgggcaaggc gatcccagag ggtgctgttg acaatggtca gctgcgcgac     1380

gttaatgagg ctatccgttc tcacgctatc gaacaagttg gcaaaaagct gcgtggttac     1440

atgaccgaca tgaagcgcat cgcggtggct ggctaa                               1476


<210>  45
<211>  493
<212>  PRT
<213>  Escherichia coli

<400>  45

Met Ala Asn Tyr Phe Asn Thr Leu Asn Leu Arg Gln Gln Leu Ala Gln 
1               5                   10                  15      


Leu Gly Lys Cys Arg Phe Met Gly Arg Asp Glu Phe Ala Asp Gly Ala 
            20                  25                  30          


Ser Tyr Leu Gln Gly Lys Lys Val Val Ile Val Gly Cys Gly Ala Gln 
        35                  40                  45              


Gly Leu Asn Gln Gly Leu Asn Met Arg Asp Ser Gly Leu Asp Ile Ser 
    50                  55                  60                  


Tyr Ala Leu Arg Lys Glu Ala Ile Ala Glu Lys Arg Ala Ser Trp Arg 
65                  70                  75                  80  


Lys Ala Thr Glu Asn Gly Phe Lys Val Gly Thr Tyr Glu Glu Leu Ile 
                85                  90                  95      


Pro Gln Ala Asp Leu Val Ile Asn Leu Thr Pro Asp Lys Val His Ser 
            100                 105                 110         


Asp Val Val Arg Thr Val Gln Pro Leu Met Lys Asp Gly Ala Ala Leu 
        115                 120                 125             


Gly Tyr Ser His Gly Phe Asn Ile Val Glu Val Gly Glu Gln Ile Arg 
    130                 135                 140                 


Lys Asp Ile Thr Val Val Met Val Ala Pro Lys Cys Pro Gly Thr Glu 
145                 150                 155                 160 


Val Arg Glu Glu Tyr Lys Arg Gly Phe Gly Val Pro Thr Leu Ile Ala 
                165                 170                 175     


Val His Pro Glu Asn Asp Pro Lys Gly Glu Gly Met Ala Ile Ala Lys 
            180                 185                 190         


Ala Trp Ala Ala Ala Thr Gly Gly His Arg Ala Gly Val Leu Glu Ser 
        195                 200                 205             


Ser Phe Val Ala Glu Val Lys Ser Asp Leu Met Gly Glu Gln Thr Ile 
    210                 215                 220                 


Leu Cys Gly Met Leu Gln Ala Gly Ser Leu Leu Cys Phe Asp Lys Leu 
225                 230                 235                 240 


Val Glu Glu Gly Thr Asp Pro Ala Tyr Ala Glu Lys Leu Ile Gln Phe 
                245                 250                 255     


Gly Trp Glu Thr Ile Thr Glu Ala Leu Lys Gln Gly Gly Ile Thr Leu 
            260                 265                 270         


Met Met Asp Arg Leu Ser Asn Pro Ala Lys Leu Arg Ala Tyr Ala Leu 
        275                 280                 285             


Ser Glu Gln Leu Lys Glu Ile Met Ala Pro Leu Phe Gln Lys His Met 
    290                 295                 300                 


Asp Asp Ile Ile Ser Gly Glu Phe Ser Ser Gly Met Met Ala Asp Trp 
305                 310                 315                 320 


Ala Asn Asp Asp Lys Lys Leu Leu Thr Trp Arg Glu Glu Thr Gly Lys 
                325                 330                 335     


Thr Ala Phe Glu Thr Ala Pro Gln Tyr Glu Gly Lys Ile Gly Glu Gln 
            340                 345                 350         


Glu Tyr Phe Asp Lys Gly Val Leu Met Ile Ala Met Val Lys Ala Gly 
        355                 360                 365             


Val Glu Leu Ala Phe Glu Thr Met Val Asp Ser Gly Ile Ile Glu Glu 
    370                 375                 380                 


Ser Ala Tyr Tyr Glu Ser Leu His Glu Leu Pro Leu Ile Ala Asn Thr 
385                 390                 395                 400 


Ile Ala Arg Lys Arg Leu Tyr Glu Met Asn Val Val Ile Ser Asp Thr 
                405                 410                 415     


Ala Glu Tyr Gly Asn Tyr Leu Phe Ser Tyr Ala Cys Val Pro Leu Leu 
            420                 425                 430         


Lys Pro Phe Met Ala Glu Leu Gln Pro Gly Asp Leu Gly Lys Ala Ile 
        435                 440                 445             


Pro Glu Gly Ala Val Asp Asn Gly Gln Leu Arg Asp Val Asn Glu Ala 
    450                 455                 460                 


Ile Arg Ser His Ala Ile Glu Gln Val Gly Lys Lys Leu Arg Gly Tyr 
465                 470                 475                 480 


Met Thr Asp Met Lys Arg Ile Ala Val Ala Gly Leu Glu 
                485                 490             


<210>  46
<211>  1476
<212>  DNA
<213>  Escherichia coli

<400>  46
atggccaact attttaacac attaaatttg agacaacaat tggctcaact gggtaagtgc       60

agatttatgg gaagggacga gtttgctgat ggtgcttctt atctgcaagg aaagaaagta      120

gtaattgttg gctgcggtgc tcagggtcta aaccaaggtt taaacatgag agattcaggt      180

ctggatattt cgtatgcatt gaggaaagag tctattgcag aaaaggatgc cgattggcgt      240

aaagcgacgg aaaatgggtt caaagttggt acttacgaag aactgatccc tcaggcagat      300

ttagtgatta acctaacacc agataaggtt cactcagacg tagtaagaac agttcaaccg      360

ctgatgaagg atggggcagc tttaggttac tctcatggct ttaatatcgt tgaagtgggc      420

gagcagatca gaaaaggtat aacagtcgta atggttgcgc caaagtgccc aggtacggaa      480

gtcagagagg agtacaagag gggttttggt gtacctacat tgatcgccgt acatcctgaa      540

aatgacccca aacgtgaagg tatggcaata gcgaaggcat gggcagccgc aaccggaggt      600

catagagcgg gtgtgttaga gagttctttc gtagctgagg tcaagagtga cttaatgggt      660

gaacaaacca ttctgtgcgg aatgttgcag gcagggtctt tactatgctt tgataaattg      720

gtcgaagagg gtacagatcc tgcctatgct gaaaagttga tacaatttgg ttgggagaca      780

atcaccgagg cacttaaaca aggtggcata acattgatga tggatagact ttcaaatccg      840

gccaagctaa gagcctacgc cttatctgag caactaaaag agatcatggc accattattc      900

caaaagcaca tggacgatat tatctccggt gagttttcct caggaatgat ggcagattgg      960

gcaaacgatg ataaaaagtt attgacgtgg agagaagaaa ccggcaagac ggcattcgag     1020

acagccccac aatacgaagg taaaattggt gaacaagaat actttgataa gggagtattg     1080

atgatagcta tggtgaaggc aggggtagaa cttgcattcg aaactatggt tgactccggt     1140

atcattgaag aatctgcata ctatgagtct ttgcatgaat tgcctttgat agcaaatact     1200

attgcaagaa aaagacttta cgagatgaat gttgtcatat cagacactgc agaatatggt     1260

aattacttat ttagctacgc gtgtgtcccg ttgttagagc ccttcatggc cgagttacaa     1320

cctggtgatt tggggaaggc tattccggaa ggagcggttg acaatggcca actgagagac     1380

gtaaatgaag ctattcgttc gcatgctata gaacaggtgg gtaaaaagct gagaggatat     1440

atgaccgata tgaaaagaat tgcagtggca ggatga                               1476


<210>  47
<211>  491
<212>  PRT
<213>  Escherichia coli

<400>  47

Met Ala Asn Tyr Phe Asn Thr Leu Asn Leu Arg Gln Gln Leu Ala Gln 
1               5                   10                  15      


Leu Gly Lys Cys Arg Phe Met Gly Arg Asp Glu Phe Ala Asp Gly Ala 
            20                  25                  30          


Ser Tyr Leu Gln Gly Lys Lys Val Val Ile Val Gly Cys Gly Ala Gln 
        35                  40                  45              


Gly Leu Asn Gln Gly Leu Asn Met Arg Asp Ser Gly Leu Asp Ile Ser 
    50                  55                  60                  


Tyr Ala Leu Arg Lys Glu Ser Ile Ala Glu Lys Asp Ala Asp Trp Arg 
65                  70                  75                  80  


Lys Ala Thr Glu Asn Gly Phe Lys Val Gly Thr Tyr Glu Glu Leu Ile 
                85                  90                  95      


Pro Gln Ala Asp Leu Val Ile Asn Leu Thr Pro Asp Lys Val His Ser 
            100                 105                 110         


Asp Val Val Arg Thr Val Gln Pro Leu Met Lys Asp Gly Ala Ala Leu 
        115                 120                 125             


Gly Tyr Ser His Gly Phe Asn Ile Val Glu Val Gly Glu Gln Ile Arg 
    130                 135                 140                 


Lys Gly Ile Thr Val Val Met Val Ala Pro Lys Cys Pro Gly Thr Glu 
145                 150                 155                 160 


Val Arg Glu Glu Tyr Lys Arg Gly Phe Gly Val Pro Thr Leu Ile Ala 
                165                 170                 175     


Val His Pro Glu Asn Asp Pro Lys Arg Glu Gly Met Ala Ile Ala Lys 
            180                 185                 190         


Ala Trp Ala Ala Ala Thr Gly Gly His Arg Ala Gly Val Leu Glu Ser 
        195                 200                 205             


Ser Phe Val Ala Glu Val Lys Ser Asp Leu Met Gly Glu Gln Thr Ile 
    210                 215                 220                 


Leu Cys Gly Met Leu Gln Ala Gly Ser Leu Leu Cys Phe Asp Lys Leu 
225                 230                 235                 240 


Val Glu Glu Gly Thr Asp Pro Ala Tyr Ala Glu Lys Leu Ile Gln Phe 
                245                 250                 255     


Gly Trp Glu Thr Ile Thr Glu Ala Leu Lys Gln Gly Gly Ile Thr Leu 
            260                 265                 270         


Met Met Asp Arg Leu Ser Asn Pro Ala Lys Leu Arg Ala Tyr Ala Leu 
        275                 280                 285             


Ser Glu Gln Leu Lys Glu Ile Met Ala Pro Leu Phe Gln Lys His Met 
    290                 295                 300                 


Asp Asp Ile Ile Ser Gly Glu Phe Ser Ser Gly Met Met Ala Asp Trp 
305                 310                 315                 320 


Ala Asn Asp Asp Lys Lys Leu Leu Thr Trp Arg Glu Glu Thr Gly Lys 
                325                 330                 335     


Thr Ala Phe Glu Thr Ala Pro Gln Tyr Glu Gly Lys Ile Gly Glu Gln 
            340                 345                 350         


Glu Tyr Phe Asp Lys Gly Val Leu Met Ile Ala Met Val Lys Ala Gly 
        355                 360                 365             


Val Glu Leu Ala Phe Glu Thr Met Val Asp Ser Gly Ile Ile Glu Glu 
    370                 375                 380                 


Ser Ala Tyr Tyr Glu Ser Leu His Glu Leu Pro Leu Ile Ala Asn Thr 
385                 390                 395                 400 


Ile Ala Arg Lys Arg Leu Tyr Glu Met Asn Val Val Ile Ser Asp Thr 
                405                 410                 415     


Ala Glu Tyr Gly Asn Tyr Leu Phe Ser Tyr Ala Cys Val Pro Leu Leu 
            420                 425                 430         


Glu Pro Phe Met Ala Glu Leu Gln Pro Gly Asp Leu Gly Lys Ala Ile 
        435                 440                 445             


Pro Glu Gly Ala Val Asp Asn Gly Gln Leu Arg Asp Val Asn Glu Ala 
    450                 455                 460                 


Ile Arg Ser His Ala Ile Glu Gln Val Gly Lys Lys Leu Arg Gly Tyr 
465                 470                 475                 480 


Met Thr Asp Met Lys Arg Ile Ala Val Ala Gly 
                485                 490     


<210>  48
<211>  1647
<212>  DNA
<213>  Lactococcus lactis

<400>  48
atgtatactg ttggtgatta tctgctggac cgtctgcatg aactgggtat cgaagaaatc       60

ttcggcgttc cgggtgatta caatctgcag ttcctggatc agatcatctc tcataaagac      120

atgaaatggg tgggtaacgc taacgaactg aacgcaagct acatggcaga tggttatgca      180

cgtaccaaga aagccgcggc atttctgacc actttcggtg ttggcgaact gagcgccgtc      240

aacggtctgg cgggctccta cgccgaaaac ctgccggtgg tggagatcgt aggcagccca      300

acgagcaaag ttcagaacga aggtaaattc gtccaccaca ctctggctga cggcgatttc      360

aaacacttca tgaaaatgca tgaacctgtg actgcggcac gtacgctgct gactgcagag      420

aacgctactg tggaaatcga ccgcgttctg tctgcgctgc tgaaagaacg caaaccagtt      480

tacatcaacc tgcctgtgga tgttgcggca gctaaagcgg aaaaaccgag cctgccgctg      540

aagaaagaaa actccacttc taacactagc gaccaggaaa tcctgaacaa aatccaggag      600

tctctgaaaa acgcaaagaa accaatcgtg atcaccggcc acgaaatcat ttcttttggt      660

ctggagaaga ccgtgaccca attcatcagc aaaaccaaac tgccgattac caccctgaac      720

ttcggcaagt cctctgttga cgaggctctg ccgtctttcc tgggcatcta caacggtact      780

ctgagcgaac cgaacctgaa agaatttgtt gaatctgcgg acttcatcct gatgctgggc      840

gttaaactga ccgactcttc taccggtgca ttcactcacc atctgaacga aaacaaaatg      900

attagcctga acatcgacga gggtaaaatc ttcaacgagc gtatccagaa cttcgacttc      960

gaaagcctga tcagctctct gctggacctg tccgaaatcg agtataaagg caaatacatt     1020

gacaaaaagc aagaagattt cgtaccatct aacgcactgc tgtcccagga tcgcctgtgg     1080

caggccgtgg agaacctgac ccagagcaat gaaaccatcg tggcggaaca aggtacgagc     1140

tttttcggcg cgtcttctat ctttctgaaa tccaaaagcc attttatcgg tcagccgctg     1200

tggggtagca ttggctatac tttcccggca gcgctgggct ctcagatcgc tgataaagaa     1260

tctcgtcatc tgctgttcat cggtgacggt tccctgcagc tgaccgtaca ggaactgggt     1320

ctggcaattc gtgaaaagat caacccgatt tgcttcatta ttaacaatga cggctacacc     1380

gttgagcgtg agatccacgg tccgaaccag tcttacaacg atatccctat gtggaactac     1440

tctaaactgc cggagtcctt cggcgcaact gaggaccgtg ttgtgtctaa aattgtgcgt     1500

accgaaaacg aatttgtgag cgtgatgaaa gaggcccagg ccgatccgaa ccgtatgtac     1560

tggatcgaac tgatcctggc gaaagaaggc gcaccgaagg tactgaagaa aatgggcaag     1620

ctgtttgctg aacagaataa atcctaa                                         1647


<210>  49
<211>  548
<212>  PRT
<213>  Lactococcus lactis

<400>  49

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser His Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Arg Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Gly Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  50
<211>  1713
<212>  DNA
<213>  Lactococcus lactis

<400>  50
atggagttta agtataacgg caaagttgaa tctgttgaac tgaataagta cagcaaaacg       60

ttgacacaag atcccacaca acccgccaca caggcaatgt attacggcat cgggtttaaa      120

gacgaagatt tcaagaaagc tcaagtgggt atagtgtcga tggactggga tggaaatcca      180

tgcaacatgc atttaggaac ccttggatca aagattaaaa gctcagtaaa tcagacagat      240

ggtctgatcg gcttacaatt tcatacgata ggagtttctg atgggatagc aaatggaaag      300

ttgggaatga gatactccct tgtttccaga gaagttatag ctgactctat tgaaaccaac      360

gctggcgctg aatactatga tgcaattgta gccatcccag gttgtgacaa aaatatgcca      420

ggttctatta ttggtatggc aagacttaat aggccaagca ttatggtgta tggaggaaca      480

atagaacacg gtgaatataa aggtgagaaa ttgaacatcg tatcggcttt tgaatctcta      540

ggccagaaaa ttaccggcaa tatctctgat gaagattatc acggtgttat ttgtaatgct      600

attcctggtc aaggggcatg tggggggatg tacacagcta ataccttagc tgccgctatc      660

gaaacactag gtatgtcatt gccgtattct tcttcgaacc ctgcagtatc tcaagaaaaa      720

caagaagaat gtgatgagat tggattagcc attaagaatc ttttggaaaa agacatcaag      780

cctagtgata taatgactaa ggaggcgttc gagaacgcta ttaccattgt gatggtcttg      840

gggggtagta ctaatgctgt cttgcatatt attgcaatgg ctaacgcgat aggtgtcgaa      900

ataactcagg atgacttcca aagaattagt gacattactc cagtactagg tgattttaaa      960

ccttcaggta aatatatgat ggaagatttg cataaaattg gaggcttgcc agcagtgctt     1020

aagtaccttc taaaggaagg aaaattgcat ggtgactgcc ttactgtgac gggtaaaaca     1080

ttagccgaga atgtcgagac tgccctagac ttggatttcg actcacaaga tatcatgagg     1140

ccactaaaga atcctatcaa ggccaccggc cacttgcaga ttctgtacgg taatttagct     1200

caagggggtt ccgtagcaaa aattagcggt aaagaaggag agttcttcaa aggcactgcc     1260

agagtctttg atggtgaaca acattttatc gacggcatag aatctggtcg tttgcatgct     1320

ggagatgtag cggtaattag gaatataggt cccgtcggcg gacctggtat gcccgaaatg     1380

ctgaagccta catcagcatt aattggtgcg ggtttaggga aaagttgcgc gttaattacg     1440

gatggtagat tctccggtgg cactcacggt tttgttgtcg gccatattgt gcctgaagcc     1500

gttgagggtg gactaatcgg cttagttgaa gatgacgata taatagagat agatgcagtc     1560

aacaactcta tatccctgaa agtttccgat gaagaaatcg caaagagaag agctaattat     1620

cagaagccaa ctccgaaagc caccagggga gttttggcaa aattcgctaa attaacccgt     1680

cctgcatcgg aagggtgtgt tactgatctg taa                                  1713


<210>  51
<211>  570
<212>  PRT
<213>  Lactococcus lactis

<400>  51

Met Glu Phe Lys Tyr Asn Gly Lys Val Glu Ser Val Glu Leu Asn Lys 
1               5                   10                  15      


Tyr Ser Lys Thr Leu Thr Gln Asp Pro Thr Gln Pro Ala Thr Gln Ala 
            20                  25                  30          


Met Tyr Tyr Gly Ile Gly Phe Lys Asp Glu Asp Phe Lys Lys Ala Gln 
        35                  40                  45              


Val Gly Ile Val Ser Met Asp Trp Asp Gly Asn Pro Cys Asn Met His 
    50                  55                  60                  


Leu Gly Thr Leu Gly Ser Lys Ile Lys Ser Ser Val Asn Gln Thr Asp 
65                  70                  75                  80  


Gly Leu Ile Gly Leu Gln Phe His Thr Ile Gly Val Ser Asp Gly Ile 
                85                  90                  95      


Ala Asn Gly Lys Leu Gly Met Arg Tyr Ser Leu Val Ser Arg Glu Val 
            100                 105                 110         


Ile Ala Asp Ser Ile Glu Thr Asn Ala Gly Ala Glu Tyr Tyr Asp Ala 
        115                 120                 125             


Ile Val Ala Ile Pro Gly Cys Asp Lys Asn Met Pro Gly Ser Ile Ile 
    130                 135                 140                 


Gly Met Ala Arg Leu Asn Arg Pro Ser Ile Met Val Tyr Gly Gly Thr 
145                 150                 155                 160 


Ile Glu His Gly Glu Tyr Lys Gly Glu Lys Leu Asn Ile Val Ser Ala 
                165                 170                 175     


Phe Glu Ser Leu Gly Gln Lys Ile Thr Gly Asn Ile Ser Asp Glu Asp 
            180                 185                 190         


Tyr His Gly Val Ile Cys Asn Ala Ile Pro Gly Gln Gly Ala Cys Gly 
        195                 200                 205             


Gly Met Tyr Thr Ala Asn Thr Leu Ala Ala Ala Ile Glu Thr Leu Gly 
    210                 215                 220                 


Met Ser Leu Pro Tyr Ser Ser Ser Asn Pro Ala Val Ser Gln Glu Lys 
225                 230                 235                 240 


Gln Glu Glu Cys Asp Glu Ile Gly Leu Ala Ile Lys Asn Leu Leu Glu 
                245                 250                 255     


Lys Asp Ile Lys Pro Ser Asp Ile Met Thr Lys Glu Ala Phe Glu Asn 
            260                 265                 270         


Ala Ile Thr Ile Val Met Val Leu Gly Gly Ser Thr Asn Ala Val Leu 
        275                 280                 285             


His Ile Ile Ala Met Ala Asn Ala Ile Gly Val Glu Ile Thr Gln Asp 
    290                 295                 300                 


Asp Phe Gln Arg Ile Ser Asp Ile Thr Pro Val Leu Gly Asp Phe Lys 
305                 310                 315                 320 


Pro Ser Gly Lys Tyr Met Met Glu Asp Leu His Lys Ile Gly Gly Leu 
                325                 330                 335     


Pro Ala Val Leu Lys Tyr Leu Leu Lys Glu Gly Lys Leu His Gly Asp 
            340                 345                 350         


Cys Leu Thr Val Thr Gly Lys Thr Leu Ala Glu Asn Val Glu Thr Ala 
        355                 360                 365             


Leu Asp Leu Asp Phe Asp Ser Gln Asp Ile Met Arg Pro Leu Lys Asn 
    370                 375                 380                 


Pro Ile Lys Ala Thr Gly His Leu Gln Ile Leu Tyr Gly Asn Leu Ala 
385                 390                 395                 400 


Gln Gly Gly Ser Val Ala Lys Ile Ser Gly Lys Glu Gly Glu Phe Phe 
                405                 410                 415     


Lys Gly Thr Ala Arg Val Phe Asp Gly Glu Gln His Phe Ile Asp Gly 
            420                 425                 430         


Ile Glu Ser Gly Arg Leu His Ala Gly Asp Val Ala Val Ile Arg Asn 
        435                 440                 445             


Ile Gly Pro Val Gly Gly Pro Gly Met Pro Glu Met Leu Lys Pro Thr 
    450                 455                 460                 


Ser Ala Leu Ile Gly Ala Gly Leu Gly Lys Ser Cys Ala Leu Ile Thr 
465                 470                 475                 480 


Asp Gly Arg Phe Ser Gly Gly Thr His Gly Phe Val Val Gly His Ile 
                485                 490                 495     


Val Pro Glu Ala Val Glu Gly Gly Leu Ile Gly Leu Val Glu Asp Asp 
            500                 505                 510         


Asp Ile Ile Glu Ile Asp Ala Val Asn Asn Ser Ile Ser Leu Lys Val 
        515                 520                 525             


Ser Asp Glu Glu Ile Ala Lys Arg Arg Ala Asn Tyr Gln Lys Pro Thr 
    530                 535                 540                 


Pro Lys Ala Thr Arg Gly Val Leu Ala Lys Phe Ala Lys Leu Thr Arg 
545                 550                 555                 560 


Pro Ala Ser Glu Gly Cys Val Thr Asp Leu 
                565                 570 


<210>  52
<211>  1701
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  52
atgaagaagc tcaacaagta ctcgtatatc atcactgaac ctaagggcca aggtgcgtcc       60

caggccatgc tttatgccac cggtttcaag aaggaagatt tcaagaagcc tcaagtcggg      120

gttggttcct gttggtggtc cggtaaccca tgtaacatgc atctattgga cttgaataac      180

agatgttctc aatccattga aaaagcgggt ttgaaagcta tgcagttcaa caccatcggt      240

gtttcagacg gtatctctat gggtactaaa ggtatgagat actcgttaca aagtagagaa      300

atcattgcag actcctttga aaccatcatg atggcacaac actacgatgc taacatcgcc      360

atcccatcat gtgacaaaaa catgcccggt gtcatgatgg ccatgggtag acataacaga      420

ccttccatca tggtatatgg tggtactatc ttgcccggtc atccaacatg tggttcttcg      480

aagatctcta aaaacatcga tatcgtctct gcgttccaat cctacggtga atatatttcc      540

aagcaattca ctgaagaaga aagagaagat gttgtggaac atgcatgccc aggtcctggt      600

tcttgtggtg gtatgtatac tgccaacaca atggcttctg ccgctgaagt gctaggtttg      660

accattccaa actcctcttc cttcccagcc gtttccaagg agaagttagc tgagtgtgac      720

aacattggtg aatacatcaa gaagacaatg gaattgggta ttttacctcg tgatatcctc      780

acaaaagagg cttttgaaaa cgccattact tatgtcgttg caaccggtgg gtccactaat      840

gctgttttgc atttggtggc tgttgctcac tctgcgggtg tcaagttgtc accagatgat      900

ttccaaagaa tcagtgatac tacaccattg atcggtgact tcaaaccttc tggtaaatac      960

gtcatggccg atttgattaa cgttggtggt acccaatctg tgattaagta tctatatgaa     1020

aacaacatgt tgcacggtaa cacaatgact gttaccggtg acactttggc agaacgtgca     1080

aagaaagcac caagcctacc tgaaggacaa gagattatta agccactctc ccacccaatc     1140

aaggccaacg gtcacttgca aattctgtac ggttcattgg caccaggtgg agctgtgggt     1200

aaaattaccg gtaaggaagg tacttacttc aagggtagag cacgtgtgtt cgaagaggaa     1260

ggtgccttta ttgaagcctt ggaaagaggt gaaatcaaga agggtgaaaa aaccgttgtt     1320

gttatcagat atgaaggtcc aagaggtgca ccaggtatgc ctgaaatgct aaagccttcc     1380

tctgctctga tgggttacgg tttgggtaaa gatgttgcat tgttgactga tggtagattc     1440

tctggtggtt ctcacgggtt cttaatcggc cacattgttc ccgaagccgc tgaaggtggt     1500

cctatcgggt tggtcagaga cggcgatgag attatcattg atgctgataa taacaagatt     1560

gacctattag tctctgataa ggaaatggct caacgtaaac aaagttgggt tgcacctcca     1620

cctcgttaca caagaggtac tctatccaag tatgctaagt tggtttccaa cgcttccaac     1680

ggttgtgttt tagatgcttg a                                               1701


<210>  53
<211>  566
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  53

Met Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu Pro Lys Gly 
1               5                   10                  15      


Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe Lys Lys Glu 
            20                  25                  30          


Asp Phe Lys Lys Pro Gln Val Gly Val Gly Ser Cys Trp Trp Ser Gly 
        35                  40                  45              


Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg Cys Ser Gln 
    50                  55                  60                  


Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn Thr Ile Gly 
65                  70                  75                  80  


Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg Tyr Ser Leu 
                85                  90                  95      


Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile Met Met Ala 
            100                 105                 110         


Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp Lys Asn Met 
        115                 120                 125             


Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro Ser Ile Met 
    130                 135                 140                 


Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys Gly Ser Ser 
145                 150                 155                 160 


Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln Ser Tyr Gly 
                165                 170                 175     


Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu Asp Val Val 
            180                 185                 190         


Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met Tyr Thr Ala 
        195                 200                 205             


Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr Ile Pro Asn 
    210                 215                 220                 


Ser Ser Ser Phe Pro Ala Val Ser Lys Glu Lys Leu Ala Glu Cys Asp 
225                 230                 235                 240 


Asn Ile Gly Glu Tyr Ile Lys Lys Thr Met Glu Leu Gly Ile Leu Pro 
                245                 250                 255     


Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile Thr Tyr Val 
            260                 265                 270         


Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu Val Ala Val 
        275                 280                 285             


Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe Gln Arg Ile 
    290                 295                 300                 


Ser Asp Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser Gly Lys Tyr 
305                 310                 315                 320 


Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser Val Ile Lys 
                325                 330                 335     


Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met Thr Val Thr 
            340                 345                 350         


Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser Leu Pro Glu 
        355                 360                 365             


Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys Ala Asn Gly 
    370                 375                 380                 


His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly Ala Val Gly 
385                 390                 395                 400 


Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Arg Ala Arg Val 
                405                 410                 415     


Phe Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Arg Gly Glu Ile 
            420                 425                 430         


Lys Lys Gly Glu Lys Thr Val Val Val Ile Arg Tyr Glu Gly Pro Arg 
        435                 440                 445             


Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser Ala Leu Met 
    450                 455                 460                 


Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp Gly Arg Phe 
465                 470                 475                 480 


Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val Pro Glu Ala 
                485                 490                 495     


Ala Glu Gly Gly Pro Ile Gly Leu Val Arg Asp Gly Asp Glu Ile Ile 
            500                 505                 510         


Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Val Ser Asp Lys Glu 
        515                 520                 525             


Met Ala Gln Arg Lys Gln Ser Trp Val Ala Pro Pro Pro Arg Tyr Thr 
    530                 535                 540                 


Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn Ala Ser Asn 
545                 550                 555                 560 


Gly Cys Val Leu Asp Ala 
                565     


<210>  54
<211>  771
<212>  DNA
<213>  Drosophila melanogaster

<400>  54
atgtcgttta ctttgaccaa caagaacgtg attttcgttg ccggtctggg aggcattggt       60

ctggacacca gcaaggagct gctcaagcgc gatctgaaga acctggtgat cctcgaccgc      120

attgagaacc cggctgccat tgccgagctg aaggcaatca atccaaaggt gaccgtcacc      180

ttctacccct atgatgtgac cgtgcccatt gccgagacca ccaagctgct gaagaccatc      240

ttcgcccagc tgaagaccgt cgatgtcctg atcaacggag ctggtatcct ggacgatcac      300

cagatcgagc gcaccattgc cgtcaactac actggcctgg tcaacaccac gacggccatt      360

ctggacttct gggacaagcg caagggcggt cccggtggta tcatctgcaa cattggatcc      420

gtcactggat tcaatgccat ctaccaggtg cccgtctact ccggcaccaa ggccgccgtg      480

gtcaacttca ccagctccct ggcgaaactg gcccccatta ccggcgtgac ggcttacact      540

gtgaaccccg gcatcacccg caccaccctg gtgcacacgt tcaactcctg gttggatgtt      600

gagcctcagg ttgccgagaa gctcctggct catcccaccc agccctcgtt ggcctgcgcc      660

gagaacttcg tcaaggctat cgagctgaac cagaacggag ccatctggaa actggacttg      720

ggcaccctgg aggccatcca gtggaccaag cactgggact ccggcatcta a               771


<210>  55
<211>  256
<212>  PRT
<213>  Drosophila melanogaster

<400>  55

Met Ser Phe Thr Leu Thr Asn Lys Asn Val Ile Phe Val Ala Gly Leu 
1               5                   10                  15      


Gly Gly Ile Gly Leu Asp Thr Ser Lys Glu Leu Leu Lys Arg Asp Leu 
            20                  25                  30          


Lys Asn Leu Val Ile Leu Asp Arg Ile Glu Asn Pro Ala Ala Ile Ala 
        35                  40                  45              


Glu Leu Lys Ala Ile Asn Pro Lys Val Thr Val Thr Phe Tyr Pro Tyr 
    50                  55                  60                  


Asp Val Thr Val Pro Ile Ala Glu Thr Thr Lys Leu Leu Lys Thr Ile 
65                  70                  75                  80  


Phe Ala Gln Leu Lys Thr Val Asp Val Leu Ile Asn Gly Ala Gly Ile 
                85                  90                  95      


Leu Asp Asp His Gln Ile Glu Arg Thr Ile Ala Val Asn Tyr Thr Gly 
            100                 105                 110         


Leu Val Asn Thr Thr Thr Ala Ile Leu Asp Phe Trp Asp Lys Arg Lys 
        115                 120                 125             


Gly Gly Pro Gly Gly Ile Ile Cys Asn Ile Gly Ser Val Thr Gly Phe 
    130                 135                 140                 


Asn Ala Ile Tyr Gln Val Pro Val Tyr Ser Gly Thr Lys Ala Ala Val 
145                 150                 155                 160 


Val Asn Phe Thr Ser Ser Leu Ala Lys Leu Ala Pro Ile Thr Gly Val 
                165                 170                 175     


Thr Ala Tyr Thr Val Asn Pro Gly Ile Thr Arg Thr Thr Leu Val His 
            180                 185                 190         


Thr Phe Asn Ser Trp Leu Asp Val Glu Pro Gln Val Ala Glu Lys Leu 
        195                 200                 205             


Leu Ala His Pro Thr Gln Pro Ser Leu Ala Cys Ala Glu Asn Phe Val 
    210                 215                 220                 


Lys Ala Ile Glu Leu Asn Gln Asn Gly Ala Ile Trp Lys Leu Asp Leu 
225                 230                 235                 240 


Gly Thr Leu Glu Ala Ile Gln Trp Thr Lys His Trp Asp Ser Gly Ile 
                245                 250                 255     


<210>  56
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  56
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgattat ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgcttca agttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatatt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtgattatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcac ttcccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

taa                                                                   1023


<210>  57
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  57

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Tyr Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ile Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Leu Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  58
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  58
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagattac ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcaa tcgtggttgc agattatgcc gtcaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcatcatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctt tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  59
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  59

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Tyr Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ile Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Leu Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  60
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  60
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  61
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  61

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV698

<400>  62
actcgccgat agtggaaacc gacg                                              24


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV1965

<400>  63
caaactgtga tggacgacac c                                                 21


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2631

<400>  64
caatacgtta tgccgtaatg aag                                               23


<210>  65
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2632

<400>  65
gctttttacc cattattgat atagtgttta agcgaatg                               38


<210>  66
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2633

<400>  66
cactatatca ataatgggta aaaagcctga actcac                                 36


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2634

<400>  67
ttattccttt gccctcggac g                                                 21


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2680

<400>  68
tgcactgctg tcttcacttc                                                   20


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2796

<400>  69
tgtcagcgct tcagactc                                                     18


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2797

<400>  70
aagtattttt aaggattcgc tc                                                22


<210>  71
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2798

<400>  71
cttcattacg gcataacgta ttgaagtatt tttaaggatt cgctc                       45


<210>  72
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2800

<400>  72
cgtccgaggg caaaggaata agatagttat cattatgtaa gtgcg                       45


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2801

<400>  73
gggagtttag caatcagc                                                     18


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2802

<400>  74
tggttgaccc gcaaacttc                                                    19


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2803

<400>  75
acaatctccc tgtctcctcc c                                                 21


<210>  76
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2804

<400>  76
aaggtgattt ggcacaaatt ttac                                              24


<210>  77
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2805

<400>  77
ggtacaattc tgtcctgaat tgtag                                             25


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2806

<400>  78
aggtcctaga aatcccttaa g                                                 21


<210>  79
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer oGV2808

<400>  79
cttcattacg gcataacgta ttgcgatatc agtatacaag gtaggc                      46


<210>  80
<211>  44
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2810

<400>  80
cgtccgaggg caaaggaata aggatttaag atgagtggta ttgg                        44


<210>  81
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2811

<400>  81
tgttcgtaac ttttgtcatc ac                                                22


<210>  82
<211>  19
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2812

<400>  82
tcagcatgcg gaacaattg                                                    19


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2813

<400>  83
tccacacggt atcatacgat c                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2814

<400>  84
gcggtcgaca agttcaatat g                                                 21


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2815

<400>  85
tactgagccg ccaaccttag ta                                                22


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2816

<400>  86
cataactata cccgtacgca g                                                 21


<210>  87
<211>  45
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2818

<400>  87
cttcattacg gcataacgta ttgagcgtag atctactgaa catgc                       45


<210>  88
<211>  40
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2820

<400>  88
cgtccgaggg caaaggaata acatgagatt gtcaaagagg                             40


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2821

<400>  89
caccaggctt attgatgacc                                                   20


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2822

<400>  90
cattaccggc agttgctc                                                     18


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2824

<400>  91
tatgacagtg cctatcaagc                                                   20


<210>  92
<211>  19
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2825

<400>  92
aatgggttct accagtatc                                                    19


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2826

<400>  93
aagccgggaa cgtgcgtaac                                                   20


<210>  94
<211>  43
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2827

<400>  94
cttcattacg gcataacgta ttgggaacgc gtaatggtgc ttg                         43


<210>  95
<211>  41
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2828

<400>  95
cgtccgaggg caaaggaata acccgagttg actgctcatt g                           41


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2829

<400>  96
aatactcgcc gaggcgtagg                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2830

<400>  97
ttggagctgg gaggtaaatc                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2831

<400>  98
tgcggctaac ccatattgag                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2832

<400>  99
tacgctgagc gtagtacaac                                                   20


<210>  100
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2833

<400>  100
taaagcgctg ggtggacaac cg                                                22


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2834

<400>  101
gcaccgagac gtcattgttg                                                   20


<210>  102
<211>  43
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2835

<400>  102
cttcattacg gcataacgta ttgtaaacac gccaggcttg acc                         43


<210>  103
<211>  41
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2836

<400>  103
cgtccgaggg caaaggaata atccattcgg tggtgttaag c                           41


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2837

<400>  104
atggcgaaat ggcagtactc                                                   20


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2838

<400>  105
accaacgacc caagaatc                                                     18


<210>  106
<211>  18
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2839

<400>  106
ctttgcgaca gtgacaac                                                     18


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2840

<400>  107
cctcacgtaa gggcatgata g                                                 21


<210>  108
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2841

<400>  108
gcattgcagc ggtattgtca gg                                                22


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2842

<400>  109
cagcagccac atagtatacc                                                   20


<210>  110
<211>  43
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2843

<400>  110
cttcattacg gcataacgta ttgagccgtc gtttgacatg ttg                         43


<210>  111
<211>  41
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2844

<400>  111
cgtccgaggg caaaggaata acgctccatt tggagggatc g                           41


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2845

<400>  112
gaatgcgctt gctgctaggg                                                   20


<210>  113
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2846

<400>  113
cagctcttgc tgcaggtaac ac                                                22


<210>  114
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2847

<400>  114
ggcacaatct tggagccgtt ag                                                22


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2848

<400>  115
accaagccat caaggttgtc                                                   20


<210>  116
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2849

<400>  116
tgggtgatgg tttggcgaat gc                                                22


<210>  117
<211>  28
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2896

<400>  117
gaaatgatga catgtggaaa tataacag                                          28


<210>  118
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 893

<400>  118
ggatgtgaag tcgttgacac ag                                                22


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2231

<400>  119
ttgaaacgtt gggtccatac                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2232

<400>  120
ttcaccgtgt gctagagaac                                                   20


<210>  121
<211>  28
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2862

<400>  121
ttatacagga aacttaatag aacaaatc                                          28


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2867

<400>  122
tgaaacagca tggcgcatag                                                   20


<210>  123
<211>  42
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2869

<400>  123
ctgtgtcaac gacttcacat ccgaggtaac gaggaacaag cc                          42


<210>  124
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2870

<400>  124
tttcgccggt atattccgta g                                                 21


<210>  125
<211>  45
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2891

<400>  125
gttctattaa gtttcctgta taacggcatt gttcaccaga atgtc                       45


<210>  126
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2902

<400>  126
tcccgacggc tgctagaatg                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2904

<400>  127
cgctccccat taattataca                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2913

<400>  128
gaaaggctct tggcagtgac                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2914

<400>  129
gccctggtgc aattagaatg                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2915

<400>  130
tgcagagggt gatgagtaag                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2916

<400>  131
ggccaaaggt aaggagaacg                                                   20


<210>  132
<211>  25
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 821

<400>  132
cgggtaatta acgacaccct agagg                                             25


<210>  133
<211>  26
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2320

<400>  133
ggctgtgtag aagtactcgc cgatag                                            26


<210>  134
<211>  58
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3065

<400>  134
aaaaaggagt agaaacattt tgaagctatg cgttgataag ggcaacaacg ttagtatc         58


<210>  135
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3066

<400>  135
atactaacgt tgttgccctt atcaacgcat agcttcaaaa tgtttctact ccttttttac       60


<210>  136
<211>  58
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3067

<400>  136
tcaaattttt cttttttttc tgtacagtta cccaagctgt tttgcctatt ttcaaagc         58


<210>  137
<211>  57
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3068

<400>  137
gctttgaaaa taggcaaaac agcttgggta actgtacaga aaaaaaagaa aaatttg          57


<210>  138
<211>  29
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3069

<400>  138
agttcaaatc agttcgagga taatttaag                                         29


<210>  139
<211>  32
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3070

<400>  139
ttaataaatg ctcaaaagaa aaaaggctgg cg                                     32


<210>  140
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3103

<400>  140
accggtgctt ctgcaggtat tg                                                22


<210>  141
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3106

<400>  141
atgcttggtt ggaagcaaat ac                                                22


<210>  142
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3498

<400>  142
atgtctcaag gtagaagagc tg                                                22


<210>  143
<211>  52
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3137

<400>  143
ggagtagaaa cattttgaag ctatgtatat cttctgaatc aattgcaccg ac               52


<210>  144
<211>  55
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3140

<400>  144
caaatttttc ttttttttct gtacagagag gtatgattaa taccaatgtc ttggg            55


<210>  145
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3499

<400>  145
tcattcacca cggtaaatgt gg                                                22


<210>  146
<211>  52
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3138

<400>  146
gtcggtgcaa ttgattcaga agatatacat agcttcaaaa tgtttctact cc               52


<210>  147
<211>  57
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3139

<400>  147
gtattaatca tacctctctg tacagaaaaa aaagaaaaat ttgaaatata aataacg          57


<210>  148
<211>  35
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3501

<400>  148
gaaggaaatt ccagtctcct agttcctttg aacac                                  35


<210>  149
<211>  26
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 2320

<400>  149
ggctgtgtag aagtactcgc cgatag                                            26


<210>  150
<211>  34
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3500

<400>  150
cagaacaatc aatcaacgaa cgaacgaccc accc                                   34


<210>  151
<211>  25
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 821

<400>  151
cgggtaatta acgacaccct agagg                                             25


<210>  152
<211>  29
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer 3141

<400>  152
aaggagatgc ttggtttgta gcaaacacc                                         29


<210>  153
<211>  58
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3065

<400>  153
aaaaaggagt agaaacattt tgaagctatg cgttgataag ggcaacaacg ttagtatc         58


<210>  154
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3066

<400>  154
atactaacgt tgttgccctt atcaacgcat agcttcaaaa tgtttctact ccttttttac       60


<210>  155
<211>  58
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3067

<400>  155
tcaaattttt cttttttttc tgtacagtta cccaagctgt tttgcctatt ttcaaagc         58


<210>  156
<211>  57
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3068

<400>  156
gctttgaaaa taggcaaaac agcttgggta actgtacaga aaaaaaagaa aaatttg          57


<210>  157
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3103

<400>  157
accggtgctt ctgcaggtat tg                                                22


<210>  158
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3106

<400>  158
atgcttggtt ggaagcaaat ac                                                22


<210>  159
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV1321

<400>  159
aatcatatcg aacacgatgc                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV1324

<400>  160
agctggtctg gtgattctac                                                   20


<210>  161
<211>  780
<212>  DNA
<213>  Schizosaccharomyces pombe

<400>  161
atgagccgtt tggatggaaa aacgatttta atcactggtg cctcttctgg aattggaaaa       60

agcactgctt ttgaaattgc caaagttgcc aaagtaaaac ttattttggc tgctcgcaga      120

ttttctaccg ttgaagaaat tgcaaaggag ttagaatcga aatatgaagt atcggttctt      180

cctcttaaat tggatgtttc tgatttgaag tctattcctg gggtaattga gtcattgcca      240

aaggaatttg ctgatatcga tgtcttgatt aataatgctg gacttgctct aggtaccgat      300

aaagtcattg atcttaatat tgatgacgcc gttaccatga ttactaccaa tgttcttggt      360

atgatggcta tgactcgtgc ggttcttcct atattctaca gcaaaaacaa gggtgatatt      420

ttgaacgttg gcagtattgc cggcagagaa tcatacgtag gcggctccgt ttactgctct      480

accaagtctg cccttgctca attcacttcc gctttgcgta aggagactat tgacactcgc      540

attcgtatta tggaggttga tcctggcttg gtcgaaaccg aattcagcgt tgtgagattc      600

cacggagaca aacaaaaggc tgataatgtt tacaaaaata gtgagccttt gacacccgaa      660

gacattgctg aggtgattct ttttgccctc actcgcagag aaaacgtcgt tattgccgat      720

acacttgttt tcccatccca tcaaggtggt gccaatcatg tgtacagaaa gcaagcgtag      780


<210>  162
<211>  23
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3490

<400>  162
gtcaagattg ttgaacaaaa gcc                                               23


<210>  163
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3492

<400>  163
gagtaaaaaa ggagtagaaa cattttgaag ctatggttta gtggggttgg ggaagctggc       60


<210>  164
<211>  59
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3493

<400>  164
caaatttttc ttttttttct gtacaggcca acatcaagaa gactattcca aacttggtc        59


<210>  165
<211>  25
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3495

<400>  165
tgtatgattc gaaagcttct tcacc                                             25


<210>  166
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3491

<400>  166
gccagcttcc ccaaccccac taaaccatag cttcaaaatg tttctactcc ttttttactc       60


<210>  167
<211>  59
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3494

<400>  167
gaccaagttt ggaatagtct tcttgatgtt ggcctgtaca gaaaaaaaag aaaaatttg        59


<210>  168
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3497

<400>  168
ttactcgagc ttgattctga c                                                 21


<210>  169
<211>  26
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2320

<400>  169
ggctgtgtag aagtactcgc cgatag                                            26


<210>  170
<211>  21
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3496

<400>  170
atgtcttcat cactagcaga g                                                 21


<210>  171
<211>  25
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV0821

<400>  171
cgggtaatta acgacaccct agagg                                             25


<210>  172
<211>  23
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV0706

<400>  172
ggttggtatt ccagctggtg tcg                                               23


<210>  173
<211>  24
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3502

<400>  173
gaaacacagt ggattagtgc tgtc                                              24


<210>  174
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3504

<400>  174
gaagagtaaa aaaggagtag aaacattttg aagctatgct ctttgtaatt gttgttggtg       60


<210>  175
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3505

<400>  175
caaatttttc ttttttttct gtacaaacag agtccatccg tttgaaactg attgcatgtc       60


<210>  176
<211>  22
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3507

<400>  176
tcaaattcta ttatcgcgcg gg                                                22


<210>  177
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3503

<400>  177
caccaacaac aattacaaag agcatagctt caaaatgttt ctactccttt tttactcttc       60


<210>  178
<211>  60
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3506

<400>  178
gacatgcaat cagtttcaaa cggatggact ctgtttgtac agaaaaaaaa gaaaaatttg       60


<210>  179
<211>  26
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3509

<400>  179
ctcctccgtt gcagaacaag gctttg                                            26


<210>  180
<211>  26
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV2320

<400>  180
ggctgtgtag aagtactcgc cgatag                                            26


<210>  181
<211>  26
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3508

<400>  181
cggtgttaag tgccagaaat tggttg                                            26


<210>  182
<211>  25
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV0821

<400>  182
cgggtaatta acgacaccct agagg                                             25


<210>  183
<211>  27
<212>  DNA
<213>  Artificial Sequence 

<220>  
<223>  primer oGV3510

<400>  183
cggcgtactc gacgtcttga gaagtag                                           27


<210>  184
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  184
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgattat ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgcttca agttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatatt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtgattatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcac ttcccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

taa                                                                   1023


<210>  185
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  185

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Tyr Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ile Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Leu Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  186
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  186
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagattac ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcaa tcgtggttgc agattatgcc gtcaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcatcatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctt tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  187
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  187

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Tyr Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ile Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Leu Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  188
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  188
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagattac ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcatcatta actctggtga cgtttaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  189
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  189

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Tyr Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ile Ile Asn Ser Gly Asp Val Tyr Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  190
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  190
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctc tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  191
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  191

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Leu Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  192
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  192
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  193
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  193

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  194
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  194
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctccg agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agccaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  195
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  195

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Arg Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Ala Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  196
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  196
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga attcaaaaac gctggtttta gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

caccaccacc accaccacta a                                               1041


<210>  197
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  197

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Phe Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  198
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  198
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgcttca agttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtggcaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

caccaccacc accaccacta a                                               1041


<210>  199
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  199

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ala Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  200
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  200
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgctttc tgttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtgacaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

caccaccacc accaccacta a                                               1041


<210>  201
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  201

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Ser Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  202
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  202
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgcttcg agttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtggcaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

caccaccacc accaccacta a                                               1041


<210>  203
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  203

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Arg Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ala Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  204
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  204
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgctttc tgttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtggtaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

caccaccacc accaccacta a                                               1041


<210>  205
<211>  346
<212>  PRT
<213>  Lactococcus lactis

<400>  205

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Ser Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Val Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys His His His His His His 
            340                 345     


<210>  206
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  206
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagattac ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcaa tcgtggttgc agattatgcc gtcaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcatcatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctt tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

taa                                                                   1023


<210>  207
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  207
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagattac ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcatcatta actctggtga cgtttaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

taa                                                                   1023


<210>  208
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  208

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Tyr Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ile Ile Asn Ser Gly Asp Val Tyr Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  209
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  209
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctc tgccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

taa                                                                   1023


<210>  210
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  210

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Leu Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  211
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  211
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agtcaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

taa                                                                   1023


<210>  212
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  212

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  213
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  213
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctccg agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga agccaaaaac gctggttata gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

taa                                                                   1023


<210>  214
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  214

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Arg Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Ala Lys Asn Ala Gly 
            100                 105                 110         


Tyr Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  215
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  215
atgaaggctg cagttgtccg tcacaatcct gatgggtacg ctgatcttgt agaaaaagag       60

ttgagggcca ttaagccaaa tgaggcattg ttggatatgg aatactgcgg tgtctgtcac      120

actgacctac atgttgctgc cggagatttc ggcaacaagg cagggacagt tttaggacat      180

gaaggtatag gtattgtgaa agagattggt gccgatgtta gttctctcca agtaggtgat      240

agagtgagtg ttgcttggtt tttcgaaggg tgtggacatt gcgaatactg tgtgtcaggt      300

aacgagacat tttgccgaga attcaaaaac gctggtttta gcgttgatgg tggaatggca      360

gaggaagcga tcgtggttgc agattatgcc gttaaagtcc cagatggcct agatccaata      420

gaagcatcat ctataacttg tgcaggcgtc accacttaca aagctatcaa ggtgtctggc      480

gttaagccag gagactggca agttatcttc ggagctggtg gcctgggcaa cttagctatc      540

cagtacgcca aaaacgtatt tggtgcgaag gtgatcgctg tagatatcaa tcaagataag      600

ctcaatcttg ccaaaaagat aggtgctgat gtcacaatta actctggtga cgttaaccct      660

gtagacgaaa tcaaaaagat cactggcggt ttaggtgttc aatccgcgat tgtatgtgcc      720

gttgcgagaa ttgcattcga gcaggctgta gcctcactaa agcctatggg caaaatggta      780

gccgttgctg taccaaacac agaaatgaca ttatctgtgc caacagtcgt gtttgatgga      840

gttgaagtag caggtagtct tgttggaaca agactcgatt tggccgaagc tttccaattc      900

ggtgcagaag ggaaggttaa gcctattgtc gctaccagaa agttggagga aatcaatgac      960

atcattgatg agatgaaggc ggggaagatt gaaggtagaa tggttataga cttcacgaag     1020

taa                                                                   1023


<210>  216
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  216

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Phe Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  217
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  217
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgcttca agttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtggcaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

taa                                                                   1023


<210>  218
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  218

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Gln Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ala Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  219
<211>  1041
<212>  DNA
<213>  Lactococcus lactis

<400>  219
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgctttc tgttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtgacaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

caccaccacc accaccacta a                                               1041


<210>  220
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  220

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Ser Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Thr Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  221
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  221
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgcttcg agttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtggcaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

taa                                                                   1023


<210>  222
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  222

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Arg Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Ala Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  223
<211>  1023
<212>  DNA
<213>  Lactococcus lactis

<400>  223
atgaaagcag cagtagtaag acacaatcca gatggttatg cggaccttgt tgaaaaggaa       60

cttcgagcaa tcaaacctaa tgaagctttg cttgacatgg agtattgtgg agtctgtcat      120

accgatttgc acgttgcagc aggtgatttt ggcaacaaag cagggactgt tcttggtcat      180

gaaggaattg gaattgtcaa agaaattgga gctgatgtaa gctcgctttc tgttggtgat      240

cgggtttcag tggcttggtt ctttgaagga tgtggtcact gtgaatactg tgtatctggt      300

aatgaaactt tttgtcgaga agttaaaaat gcaggatttt cagttgatgg cggaatggct      360

gaagaagcaa ttgttgttgc cgattatgct gtcaaagttc ctgacggact tgacccaatt      420

gaagctagct caattacttg tgctggagta acaacttaca aagcaatcaa agtatcagga      480

gtaaaacctg gtgattggca agtaattttt ggtgctggag gacttggaaa tttagcaatt      540

caatatgcta aaaatgtttt tggagcaaaa gtaattgctg ttgatattaa tcaagataaa      600

ttaaatttag ctaaaaaaat tggagctgat gtggtaatca attctggtga tgtaaatcca      660

gttgatgaaa ttaaaaaaat aactggcggc ttaggggtgc aaagtgcaat agtttgtgct      720

gttgcaagga ttgcttttga acaagcggtt gcttctttga aacctatggg caaaatggtt      780

gctgtggcag tacccaatac tgagatgact ttatcagttc caacagttgt ttttgacgga      840

gtggaggttg caggttcact tgtcggaaca agacttgact tggcagaagc ttttcaattt      900

ggagcagaag gtaaggtaaa accaattgtt gcgacacgca aactggaaga aatcaatgat      960

attattgatg aaatgaaggc aggaaaaatt gaaggccgaa tggtcattga ttttactaaa     1020

taa                                                                   1023


<210>  224
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  224

Met Lys Ala Ala Val Val Arg His Asn Pro Asp Gly Tyr Ala Asp Leu 
1               5                   10                  15      


Val Glu Lys Glu Leu Arg Ala Ile Lys Pro Asn Glu Ala Leu Leu Asp 
            20                  25                  30          


Met Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala Ala Gly 
        35                  40                  45              


Asp Phe Gly Asn Lys Ala Gly Thr Val Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  


Ile Val Lys Glu Ile Gly Ala Asp Val Ser Ser Leu Ser Val Gly Asp 
65                  70                  75                  80  


Arg Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly His Cys Glu Tyr 
                85                  90                  95      


Cys Val Ser Gly Asn Glu Thr Phe Cys Arg Glu Val Lys Asn Ala Gly 
            100                 105                 110         


Phe Ser Val Asp Gly Gly Met Ala Glu Glu Ala Ile Val Val Ala Asp 
        115                 120                 125             


Tyr Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ile Glu Ala Ser Ser 
    130                 135                 140                 


Ile Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Val Ser Gly 
145                 150                 155                 160 


Val Lys Pro Gly Asp Trp Gln Val Ile Phe Gly Ala Gly Gly Leu Gly 
                165                 170                 175     


Asn Leu Ala Ile Gln Tyr Ala Lys Asn Val Phe Gly Ala Lys Val Ile 
            180                 185                 190         


Ala Val Asp Ile Asn Gln Asp Lys Leu Asn Leu Ala Lys Lys Ile Gly 
        195                 200                 205             


Ala Asp Val Val Ile Asn Ser Gly Asp Val Asn Pro Val Asp Glu Ile 
    210                 215                 220                 


Lys Lys Ile Thr Gly Gly Leu Gly Val Gln Ser Ala Ile Val Cys Ala 
225                 230                 235                 240 


Val Ala Arg Ile Ala Phe Glu Gln Ala Val Ala Ser Leu Lys Pro Met 
                245                 250                 255     


Gly Lys Met Val Ala Val Ala Val Pro Asn Thr Glu Met Thr Leu Ser 
            260                 265                 270         


Val Pro Thr Val Val Phe Asp Gly Val Glu Val Ala Gly Ser Leu Val 
        275                 280                 285             


Gly Thr Arg Leu Asp Leu Ala Glu Ala Phe Gln Phe Gly Ala Glu Gly 
    290                 295                 300                 


Lys Val Lys Pro Ile Val Ala Thr Arg Lys Leu Glu Glu Ile Asn Asp 
305                 310                 315                 320 


Ile Ile Asp Glu Met Lys Ala Gly Lys Ile Glu Gly Arg Met Val Ile 
                325                 330                 335     


Asp Phe Thr Lys 
            340 


<210>  225
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer XX7

<400>  225
ggagaaaacc catatgtcgt ttac                                              24


<210>  226
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer XX9

<400>  226
gcagccgaac gctcgagggc ggccg                                             25


<210>  227
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer His_Not1_1947_rev

<400>  227
ctcgagcggc cgcttagtgg tggtggtggt ggtgtttagt aaaatcaa                    48


<210>  228
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sal1_for

<400>  228
gaaagcatag caatctaatc taagtt                                            26


<210>  229
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer adhAcoSc_SalIin_for

<400>  229
gtttgtcgac atgaaggctg cagttgtccg t                                      31


<210>  230
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer adhAcoSC_NotIin_his_rev

<400>  230
tcgagcggcc gcttagtggt ggtggtggtg gtgcttcgtg aagtctataa ccattctacc       60


<210>  231
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer pGV1994ep_for

<400>  231
cggtcttcaa tttctcaagt ttcagtttca tttttcttgt tctattacaa c                51


<210>  232
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer pGV1994ep_rev

<400>  232
ctaactcctt ccttttcggt tagagcggat gtggg                                  35


<210>  233
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer RecombADHY50_for

<400>  233
tgctgccgga gattwcggca acaaggcagg                                        30


<210>  234
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer RecombADHY50_rev

<400>  234
cctgccttgt tgccgwaatc tccggcagca                                        30


<210>  235
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer RecombADHL264_for

<400>  235
atggtagccg ttgctktacc aaacacagaa                                        30


<210>  236
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer RecombADHL264_rev

<400>  236
ttctgtgttt ggtamagcaa cggctaccat                                        30


<210>  237
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer RecombADHI212_Y219_for

<400>  237
gctgatgtca yaattaactc tggtgacgtt waccctgtag                             40


<210>  238
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer RecombADHI212_Y219_rev

<400>  238
ctacagggtw aacgtcacca gagttaattr tgacatcagc                             40


<210>  239
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHF50_for


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  239
tgctgccgga gatnnkggca acaag                                             25


<210>  240
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHF50_rev


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  240
gccttgttgc cmnnatctcc ggcag                                             25


<210>  241
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHR77_for


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  241
gttagttctc tcnnkgtagg tgatag                                            26


<210>  242
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHR77_rev


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  242
cactctatca cctacmnnga gagaac                                            26


<210>  243
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHA108_for


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<400>  243
acattttgcc gagaannkaa aaacgc                                            26


<210>  244
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHA108_rev


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  244
accagcgttt ttmnnttctc ggcaaa                                            26


<210>  245
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHF113_for


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<400>  245
gtcaaaaacg ctggtnnkag cgttga                                            26


<210>  246
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHF113_rev


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  246
accatcaacg ctmnnaccag cgtttt                                            26


<210>  247
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHT212_for


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  247
agataggtgc tgatgtcnnk attaac                                            26


<210>  248
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHT212_rev


<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is a, c, g, or t

<400>  248
cagagttaat mnngacatca gcacct                                            26


<210>  249
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHV264_for


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  249
ggtagccgtt gctnnkccaa acacag                                            26


<210>  250
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer NNKADHV264_rev


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<400>  250
atttctgtgt ttggmnnagc aacggc                                            26


<210>  251
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2F50Minilib_for

<400>  251
gttgcagcag gtgattdkgg caacaaagca                                        30


<210>  252
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2F50Minilib_rev

<400>  252
tgctttgttg ccmhaatcac ctgctgcaac                                        30


<210>  253
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2Q77Gen5_for3

<400>  253
tgatgtaagc tcgcttcaag ttggtgatcg                                        30


<210>  254
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2Q77Gen5_rev4

<400>  254
cgatcaccaa cttgaagcga gcttacatca                                        30


<210>  255
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2R77Gen5_for5

<400>  255
tgatgtaagc tcgcttcgag ttggtgatcg                                        30


<210>  256
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2R77Gen5_rev6

<400>  256
cgatcaccaa ctcgaagcga gcttacatca                                        30


<210>  257
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2S77Gen5_for7

<400>  257
tgatgtaagc tcgctttctg ttggtgatcg                                        30


<210>  258
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2S77Gen5_rev8

<400>  258
cgatcaccaa cagaaagcga gcttacatca                                        30


<210>  259
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2Y113 Gen5_for9

<400>  259
ttaaaaatgc aggatattca gttgatggcg                                        30


<210>  260
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2Y113 Gen5_rev10

<400>  260
cgccatcaac tgaatatcct gcatttttaa                                        30


<210>  261
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2F113 Gen5_for11

<400>  261
ttaaaaatgc aggattttca gttgatggcg                                        30


<210>  262
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2F113 Gen5_rev12

<400>  262
cgccatcaac tgaaaatcct gcatttttaa                                        30


<210>  263
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2G113 Gen5_for13

<400>  263
ttaaaaatgc aggagggtca gttgatggcg                                        30


<210>  264
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2G113 Gen5_rev14

<400>  264
cgccatcaac tgaccctcct gcatttttaa                                        30


<210>  265
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2T212 Mini_for15

<400>  265
gagctgatgt gryaatcaat tctggtgatg                                        30


<210>  266
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2T212 Mini_rev16

<400>  266
catcaccaga attgattryc acatcagctc                                        30


<210>  267
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2V264 Mini_for17

<400>  267
tggttgctgt ggcaktaccc aatactgaga                                        30


<210>  268
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Recomb2V264 Mini_rev18

<400>  268
tctcagtatt gggtamtgcc acagcaacca                                        30





