                         SEQUENCE LISTING

<110>  LFB Biotechnologies
 
<120>  ANTICORPS HUMANISES MUTES DIRIGES CONTRE LE RECEPTEUR DE 
       L'HORMONE ANTI-MULERIENNE DE TYPE II

<130>  WOB 10 AC LFB AMHR

<150>  FR 10/53712
<151>  2010-05-12

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  318
<212>  DNA
<213>  VL sans leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(318)

<400>  1
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg atc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

tca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Ser Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag                                318
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                                   
            100                 105                                       


<210>  2
<211>  106
<212>  PRT
<213>  VL sans leader 12G4 humanis

<220>
<223>  VL sans leader 12G4 humanis

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  3
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL avec leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(384)

<400>  3
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg atc tac tca acc tcc tcc ctg gaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Glu Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       


<210>  4
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  5
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CL 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(321)

<400>  5
cgg acc gtc gcc gca cca agt gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt                            321
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  7
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sans leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(345)

<400>  7
cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc agc agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  9
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(402)

<400>  9
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc agc agc                                                402
Leu Val Thr Val Ser Ser                                                   
    130                                                                   


<210>  10
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  11
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(990)

<400>  11
gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa                                990
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  12
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL sans leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(318)

<400>  13
caa att gtt ctc acc cag tct cca gca atc atg tct gca tct cta ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly           
1               5                   10                  15                

gag ggg atc acc cta acc tgc agt gcc agc tcg agt gta cgt tac ata         96
Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

cac tgg tac cag cag aag tca ggc act tct ccc aaa ctc ttg att tat        144
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

agc aca tcc aac ctg gct tct gga gtc cct tct cgc ttc agt ggc agt        192
Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggg tct ggg acc ttt cat tct ctc aca atc agc agt gtg gag gct gaa        240
Gly Ser Gly Thr Phe His Ser Leu Thr Ile Ser Ser Val Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc gat tat tac tgc ctt cag tgg agt agt tat ccg tgg acg        288
Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggt gga ggc acc aag ctg gaa atc aaa                                318
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  14
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe His Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  15
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL avec leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(384)

<400>  15
atg gat ttt cag gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata atg tcc aga gga caa att gtt ctc acc cag tct cca gca atc         96
Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile           
            20                  25                  30                    

atg tct gca tct cta ggg gag ggg atc acc cta acc tgc agt gcc agc        144
Met Ser Ala Ser Leu Gly Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser           
        35                  40                  45                        

tcg agt gta cgt tac ata cac tgg tac cag cag aag tca ggc act tct        192
Ser Ser Val Arg Tyr Ile His Trp Tyr Gln Gln Lys Ser Gly Thr Ser           
    50                  55                  60                            

ccc aaa ctc ttg att tat agc aca tcc aac ctg gct tct gga gtc cct        240
Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro           
65                  70                  75                  80            

tct cgc ttc agt ggc agt ggg tct ggg acc ttt cat tct ctc aca atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Phe His Ser Leu Thr Ile           
                85                  90                  95                

agc agt gtg gag gct gaa gat gct gcc gat tat tac tgc ctt cag tgg        336
Ser Ser Val Glu Ala Glu Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agt tat ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
        115                 120                 125                       


<210>  16
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Leu Gly Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Phe His Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Glu Ala Glu Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210>  17
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sans leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(345)

<400>  17
cag gtc cag ctg cag cag tct gga cct gaa ctg gtg aag cct ggg gct         48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg agg atg tcc tgc aag gct tct ggc tac acc ttc aca agt tac         96
Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cat ata cac tgg gtg aag cag agg cct gga cag gga ctt gag tgg att        144
His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tgg att tat cct ggc gat gat tct act aaa tac aat gag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag ggc aag acc aca ctg act gca gac aaa tcc tcc agc aca gcc tac        240
Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg ttg ctc agc agc ctg acc tct gag gac tct gcg atc tat ttc tgt        288
Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys           
                85                  90                  95                

aca agg ggg gac cgg ttt gct tac tgg ggc caa ggg act ctg gtc act        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tct gca                                                            345
Val Ser Ala                                                               
        115                                                               


<210>  18
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  19
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(402)

<400>  19
atg cga tgg agc tgg atc ttt ctc ttc ctc ctg tca ata act gca agt         48
Met Arg Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Ile Thr Ala Ser           
1               5                   10                  15                

gtc cat tgc cag gtc cag ctg cag cag tct gga cct gaa ctg gtg aag         96
Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys           
            20                  25                  30                    

cct ggg gct tca gtg agg atg tcc tgc aag gct tct ggc tac acc ttc        144
Pro Gly Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

aca agt tac cat ata cac tgg gtg aag cag agg cct gga cag gga ctt        192
Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu           
    50                  55                  60                            

gag tgg att gga tgg att tat cct ggc gat gat tct act aaa tac aat        240
Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn           
65                  70                  75                  80            

gag aag ttc aag ggc aag acc aca ctg act gca gac aaa tcc tcc agc        288
Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser           
                85                  90                  95                

aca gcc tac atg ttg ctc agc agc ctg acc tct gag gac tct gcg atc        336
Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile           
            100                 105                 110                   

tat ttc tgt aca agg ggg gac cgg ttt gct tac tgg ggc caa ggg act        384
Tyr Phe Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtc act gtc tct gca                                                402
Leu Val Thr Val Ser Ala                                                   
    130                                                                   


<210>  20
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Arg Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Ile Thr Ala Ser 
1               5                   10                  15      


Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala 
    130                 


<210>  21
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL sans leader 3C_23


<220>
<221>  CDS
<222>  (1)..(318)

<400>  21
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr           
        35                  40                  45                        

cca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag                                318
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                                   
            100                 105                                       


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              


Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  23
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL avec leader 3C_23


<220>
<221>  CDS
<222>  (1)..(384)

<400>  23
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg acc tac cca acc tcc tcc ctg gaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       


<210>  24
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  25
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sans leader 3C_23


<220>
<221>  CDS
<222>  (1)..(345)

<400>  25
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tcg agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  26
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  27
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 3C_23


<220>
<221>  CDS
<222>  (1)..(402)

<400>  27
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc tcg agc                                                402
Leu Val Thr Val Ser Ser                                                   
    130                                                                   


<210>  28
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  29
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL sans leader 6B_78


<220>
<221>  CDS
<222>  (1)..(318)

<400>  29
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg atc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

tca acc tcc tcc ctg aaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Ser Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag                                318
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                                   
            100                 105                                       


<210>  30
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  31
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL avec leader 6B_78


<220>
<221>  CDS
<222>  (1)..(384)

<400>  31
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg atc tac tca acc tcc tcc ctg aaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Lys Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       


<210>  32
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Lys Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  33
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL sans leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(318)

<400>  33
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr           
        35                  40                  45                        

cca acc tcc tcc ctg aaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag                                318
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                                   
            100                 105                                       


<210>  34
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              


Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  35
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL avec leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(384)

<400>  35
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg acc tac cca acc tcc tcc ctg aaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Lys Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       


<210>  36
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Lys Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  37
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sans leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(345)

<400>  37
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tcg agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(402)

<400>  39
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc tcg agc                                                402
Leu Val Thr Val Ser Ser                                                   
    130                                                                   


<210>  40
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  41
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 4C_35


<220>
<221>  CDS
<222>  (1)..(345)

<400>  41
cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga cca gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc agc agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  42
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  43
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 4C_35


<220>
<221>  CDS
<222>  (1)..(402)

<400>  43
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga cca        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc agc agc                                                402
Leu Val Thr Val Ser Ser                                                   
    130                                                                   


<210>  44
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  45
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL sans leader 5B_42


<220>
<221>  CDS
<222>  (1)..(318)

<400>  45
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg atc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

cca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag                                318
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                                   
            100                 105                                       


<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  47
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL avec leader 5B_42


<220>
<221>  CDS
<222>  (1)..(384)

<400>  47
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg atc tac cca acc tcc tcc ctg gaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Ile Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       


<210>  48
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  49
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH sans leader 5B_42


<220>
<221>  CDS
<222>  (1)..(345)

<400>  49
cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac gcc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc agc agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  50
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  51
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH avec leader 5B_42


<220>
<221>  CDS
<222>  (1)..(402)

<400>  51
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac gcc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc agc agc                                                402
Leu Val Thr Val Ser Ser                                                   
    130                                                                   


<210>  52
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  53
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre sans leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(639)

<400>  53
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg atc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

tca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Ser Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca        336
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro           
            100                 105                 110                   

agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act        384
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr           
        115                 120                 125                       

gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa        432
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys           
    130                 135                 140                           

gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag        480
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu           
145                 150                 155                 160           

agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc        528
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser           
                165                 170                 175               

acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc        576
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala           
            180                 185                 190                   

tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc        624
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe           
        195                 200                 205                       

aac agg gga gag tgt                                                    639
Asn Arg Gly Glu Cys                                                       
    210                                                                   


<210>  54
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  55
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre avec leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(705)

<400>  55
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg atc tac tca acc tcc tcc ctg gaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Glu Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       

cgg acc gtc gcc gca cca agt gtc ttc atc ttc ccg cca tct gat gag        432
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
    130                 135                 140                           

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        480
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
145                 150                 155                 160           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        528
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
                165                 170                 175               

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        576
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        624
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
        195                 200                 205                       

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        672
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
    210                 215                 220                           

ccc gtc aca aag agc ttc aac agg gga gag tgt                            705
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
225                 230                 235                               


<210>  56
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  57
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde sans leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(1335)

<400>  57
cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc agc agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc        432
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag        624
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc        672
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys           
    210                 215                 220                           

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        720
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
225                 230                 235                 240           

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        768
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
                245                 250                 255               

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        816
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
            260                 265                 270                   

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag        864
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
        275                 280                 285                       

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc        912
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
    290                 295                 300                           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag        960
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
305                 310                 315                 320           

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1008
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
                325                 330                 335               

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1056
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
            340                 345                 350                   

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1104
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
        355                 360                 365                       

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1152
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
    370                 375                 380                           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1200
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
385                 390                 395                 400           

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1248
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
                405                 410                 415               

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1296
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
            420                 425                 430                   

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                   1335
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
        435                 440                 445                       


<210>  58
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  59
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde avec leader 12G4 humanis


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  59
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc agc agc gcc agc acc aag ggc cca tcg gtc ttc ccc        432
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
    130                 135                 140                           

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc        480
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly           
145                 150                 155                 160           

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac        528
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn           
                165                 170                 175               

tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag        576
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln           
            180                 185                 190                   

tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc        624
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser           
        195                 200                 205                       

agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc agc        672
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser           
    210                 215                 220                           

aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act        720
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr           
225                 230                 235                 240           

cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca        768
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser           
                245                 250                 255               

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg        816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg           
            260                 265                 270                   

acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct        864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro           
        275                 280                 285                       

gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc        912
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala           
    290                 295                 300                           

aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc        960
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val           
305                 310                 315                 320           

agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac       1008
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr           
                325                 330                 335               

aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc       1056
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr           
            340                 345                 350                   

atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg       1104
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu           
        355                 360                 365                       

ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc       1152
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys           
    370                 375                 380                           

ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc       1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser           
385                 390                 395                 400           

aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac       1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp           
                405                 410                 415               

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc       1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser           
            420                 425                 430                   

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct       1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala           
        435                 440                 445                       

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa       1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys           
    450                 455                 460                           


<210>  60
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  61
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre sans leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(645)

<400>  61
caa att gtt ctc acc cag tct cca gca atc atg tct gca tct cta ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly           
1               5                   10                  15                

gag ggg atc acc cta acc tgc agt gcc agc tcg agt gta cgt tac ata         96
Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

cac tgg tac cag cag aag tca ggc act tct ccc aaa ctc ttg att tat        144
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

agc aca tcc aac ctg gct tct gga gtc cct tct cgc ttc agt ggc agt        192
Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggg tct ggg acc ttt cat tct ctc aca atc agc agt gtg gag gct gaa        240
Gly Ser Gly Thr Phe His Ser Leu Thr Ile Ser Ser Val Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc gat tat tac tgc ctt cag tgg agt agt tat ccg tgg acg        288
Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggt gga ggc acc aag ctg gaa atc aaa cga act gtg gct gca cca        336
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro           
            100                 105                 110                   

agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act        384
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr           
        115                 120                 125                       

gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa        432
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys           
    130                 135                 140                           

gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag        480
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu           
145                 150                 155                 160           

agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc        528
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser           
                165                 170                 175               

acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc        576
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala           
            180                 185                 190                   

tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc        624
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe           
        195                 200                 205                       

aac agg gga gag tgt tag tga                                            645
Asn Arg Gly Glu Cys                                                       
    210                                                                   


<210>  62
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe His Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  63
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre avec leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(711)

<400>  63
atg gat ttt cag gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata atg tcc aga gga caa att gtt ctc acc cag tct cca gca atc         96
Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile           
            20                  25                  30                    

atg tct gca tct cta ggg gag ggg atc acc cta acc tgc agt gcc agc        144
Met Ser Ala Ser Leu Gly Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser           
        35                  40                  45                        

tcg agt gta cgt tac ata cac tgg tac cag cag aag tca ggc act tct        192
Ser Ser Val Arg Tyr Ile His Trp Tyr Gln Gln Lys Ser Gly Thr Ser           
    50                  55                  60                            

ccc aaa ctc ttg att tat agc aca tcc aac ctg gct tct gga gtc cct        240
Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro           
65                  70                  75                  80            

tct cgc ttc agt ggc agt ggg tct ggg acc ttt cat tct ctc aca atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Phe His Ser Leu Thr Ile           
                85                  90                  95                

agc agt gtg gag gct gaa gat gct gcc gat tat tac tgc ctt cag tgg        336
Ser Ser Val Glu Ala Glu Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agt tat ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
        115                 120                 125                       

cga act gtg gct gca cca agt gtc ttc atc ttc ccg cca tct gat gag        432
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
    130                 135                 140                           

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        480
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
145                 150                 155                 160           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        528
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
                165                 170                 175               

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        576
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        624
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
        195                 200                 205                       

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        672
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
    210                 215                 220                           

ccc gtc aca aag agc ttc aac agg gga gag tgt tag tga                    711
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
225                 230                 235                               


<210>  64
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Leu Gly Glu Gly Ile Thr Leu Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Phe His Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Glu Ala Glu Asp Ala Ala Asp Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  65
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde sans leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(1335)

<400>  65
cag gtc cag ctg cag cag tct gga cct gaa ctg gtg aag cct ggg gct         48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg agg atg tcc tgc aag gct tct ggc tac acc ttc aca agt tac         96
Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cat ata cac tgg gtg aag cag agg cct gga cag gga ctt gag tgg att        144
His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tgg att tat cct ggc gat gat tct act aaa tac aat gag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag ggc aag acc aca ctg act gca gac aaa tcc tcc agc aca gcc tac        240
Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg ttg ctc agc agc ctg acc tct gag gac tct gcg atc tat ttc tgt        288
Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys           
                85                  90                  95                

aca agg ggg gac cgg ttt gct tac tgg ggc caa ggg act ctg gtc act        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tct gca gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc        384
Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc        432
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag        624
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc        672
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys           
    210                 215                 220                           

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        720
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
225                 230                 235                 240           

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        768
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
                245                 250                 255               

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        816
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
            260                 265                 270                   

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag        864
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
        275                 280                 285                       

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc        912
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
    290                 295                 300                           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag        960
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
305                 310                 315                 320           

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1008
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
                325                 330                 335               

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1056
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
            340                 345                 350                   

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1104
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
        355                 360                 365                       

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1152
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
    370                 375                 380                           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1200
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
385                 390                 395                 400           

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1248
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
                405                 410                 415               

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1296
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
            420                 425                 430                   

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                   1335
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
        435                 440                 445                       


<210>  66
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  67
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde avec leader 12G4 chimrique


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  67
atg cga tgg agc tgg atc ttt ctc ttc ctc ctg tca ata act gca agt         48
Met Arg Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Ile Thr Ala Ser           
1               5                   10                  15                

gtc cat tgc cag gtc cag ctg cag cag tct gga cct gaa ctg gtg aag         96
Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys           
            20                  25                  30                    

cct ggg gct tca gtg agg atg tcc tgc aag gct tct ggc tac acc ttc        144
Pro Gly Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

aca agt tac cat ata cac tgg gtg aag cag agg cct gga cag gga ctt        192
Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu           
    50                  55                  60                            

gag tgg att gga tgg att tat cct ggc gat gat tct act aaa tac aat        240
Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn           
65                  70                  75                  80            

gag aag ttc aag ggc aag acc aca ctg act gca gac aaa tcc tcc agc        288
Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser           
                85                  90                  95                

aca gcc tac atg ttg ctc agc agc ctg acc tct gag gac tct gcg atc        336
Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile           
            100                 105                 110                   

tat ttc tgt aca agg ggg gac cgg ttt gct tac tgg ggc caa ggg act        384
Tyr Phe Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtc act gtc tct gca gcc tcc acc aag ggc cca tcg gtc ttc ccc        432
Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
    130                 135                 140                           

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc        480
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly           
145                 150                 155                 160           

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac        528
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn           
                165                 170                 175               

tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag        576
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln           
            180                 185                 190                   

tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc        624
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser           
        195                 200                 205                       

agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc agc        672
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser           
    210                 215                 220                           

aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act        720
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr           
225                 230                 235                 240           

cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca        768
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser           
                245                 250                 255               

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg        816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg           
            260                 265                 270                   

acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct        864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro           
        275                 280                 285                       

gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc        912
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala           
    290                 295                 300                           

aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc        960
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val           
305                 310                 315                 320           

agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac       1008
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr           
                325                 330                 335               

aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc       1056
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr           
            340                 345                 350                   

atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg       1104
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu           
        355                 360                 365                       

ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc       1152
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys           
    370                 375                 380                           

ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc       1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser           
385                 390                 395                 400           

aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac       1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp           
                405                 410                 415               

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc       1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser           
            420                 425                 430                   

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct       1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala           
        435                 440                 445                       

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa       1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys           
    450                 455                 460                           


<210>  68
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Met Arg Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Ile Thr Ala Ser 
1               5                   10                  15      


Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  69
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre sans leader 3C_23


<220>
<221>  CDS
<222>  (1)..(639)

<400>  69
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr           
        35                  40                  45                        

cca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca        336
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro           
            100                 105                 110                   

agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act        384
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr           
        115                 120                 125                       

gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa        432
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys           
    130                 135                 140                           

gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag        480
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu           
145                 150                 155                 160           

agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc        528
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser           
                165                 170                 175               

acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc        576
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala           
            180                 185                 190                   

tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc        624
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe           
        195                 200                 205                       

aac agg gga gag tgt                                                    639
Asn Arg Gly Glu Cys                                                       
    210                                                                   


<210>  70
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              


Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  71
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre avec leader 3C_23


<220>
<221>  CDS
<222>  (1)..(705)

<400>  71
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg acc tac cca acc tcc tcc ctg gaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       

cgg acc gtc gcc gca cca agt gtc ttc atc ttc ccg cca tct gat gag        432
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
    130                 135                 140                           

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        480
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
145                 150                 155                 160           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        528
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
                165                 170                 175               

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        576
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        624
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
        195                 200                 205                       

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        672
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
    210                 215                 220                           

ccc gtc aca aag agc ttc aac agg gga gag tgt                            705
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
225                 230                 235                               


<210>  72
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  73
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde sans leader 3C_23


<220>
<221>  CDS
<222>  (1)..(1335)

<400>  73
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tcg agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc        432
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag        624
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc        672
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys           
    210                 215                 220                           

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        720
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
225                 230                 235                 240           

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        768
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
                245                 250                 255               

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        816
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
            260                 265                 270                   

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag        864
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
        275                 280                 285                       

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc        912
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
    290                 295                 300                           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag        960
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
305                 310                 315                 320           

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1008
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
                325                 330                 335               

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1056
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
            340                 345                 350                   

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1104
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
        355                 360                 365                       

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1152
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
    370                 375                 380                           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1200
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
385                 390                 395                 400           

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1248
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
                405                 410                 415               

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1296
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
            420                 425                 430                   

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                   1335
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
        435                 440                 445                       


<210>  74
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  75
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde avec leader 3C_23


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  75
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc tcg agc gcc agc acc aag ggc cca tcg gtc ttc ccc        432
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
    130                 135                 140                           

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc        480
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly           
145                 150                 155                 160           

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac        528
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn           
                165                 170                 175               

tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag        576
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln           
            180                 185                 190                   

tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc        624
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser           
        195                 200                 205                       

agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc agc        672
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser           
    210                 215                 220                           

aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act        720
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr           
225                 230                 235                 240           

cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca        768
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser           
                245                 250                 255               

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg        816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg           
            260                 265                 270                   

acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct        864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro           
        275                 280                 285                       

gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc        912
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala           
    290                 295                 300                           

aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc        960
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val           
305                 310                 315                 320           

agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac       1008
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr           
                325                 330                 335               

aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc       1056
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr           
            340                 345                 350                   

atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg       1104
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu           
        355                 360                 365                       

ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc       1152
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys           
    370                 375                 380                           

ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc       1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser           
385                 390                 395                 400           

aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac       1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp           
                405                 410                 415               

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc       1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser           
            420                 425                 430                   

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct       1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala           
        435                 440                 445                       

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa       1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys           
    450                 455                 460                           


<210>  76
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  77
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre sans leader 6B_78


<220>
<221>  CDS
<222>  (1)..(639)

<400>  77
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg atc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

tca acc tcc tcc ctg aaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Ser Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca        336
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro           
            100                 105                 110                   

agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act        384
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr           
        115                 120                 125                       

gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa        432
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys           
    130                 135                 140                           

gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag        480
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu           
145                 150                 155                 160           

agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc        528
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser           
                165                 170                 175               

acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc        576
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala           
            180                 185                 190                   

tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc        624
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe           
        195                 200                 205                       

aac agg gga gag tgt                                                    639
Asn Arg Gly Glu Cys                                                       
    210                                                                   


<210>  78
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  79
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre avec leader 6B_78


<220>
<221>  CDS
<222>  (1)..(705)

<400>  79
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg atc tac tca acc tcc tcc ctg aaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Lys Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       

cgg acc gtc gcc gca cca agt gtc ttc atc ttc ccg cca tct gat gag        432
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
    130                 135                 140                           

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        480
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
145                 150                 155                 160           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        528
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
                165                 170                 175               

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        576
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        624
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
        195                 200                 205                       

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        672
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
    210                 215                 220                           

ccc gtc aca aag agc ttc aac agg gga gag tgt                            705
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
225                 230                 235                               


<210>  80
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Ser Leu Lys Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  81
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre sans leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(639)

<400>  81
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr           
        35                  40                  45                        

cca acc tcc tcc ctg aaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca        336
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro           
            100                 105                 110                   

agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act        384
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr           
        115                 120                 125                       

gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa        432
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys           
    130                 135                 140                           

gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag        480
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu           
145                 150                 155                 160           

agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc        528
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser           
                165                 170                 175               

acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc        576
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala           
            180                 185                 190                   

tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc        624
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe           
        195                 200                 205                       

aac agg gga gag tgt                                                    639
Asn Arg Gly Glu Cys                                                       
    210                                                                   


<210>  82
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              


Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  83
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre avec leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(705)

<400>  83
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg acc tac cca acc tcc tcc ctg aaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Lys Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       

cgg acc gtc gcc gca cca agt gtc ttc atc ttc ccg cca tct gat gag        432
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
    130                 135                 140                           

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        480
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
145                 150                 155                 160           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        528
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
                165                 170                 175               

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        576
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        624
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
        195                 200                 205                       

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        672
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
    210                 215                 220                           

ccc gtc aca aag agc ttc aac agg gga gag tgt                            705
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
225                 230                 235                               


<210>  84
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Thr Tyr Pro Thr Ser Ser Leu Lys Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  85
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde sans leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(1335)

<400>  85
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tcg agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc        432
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag        624
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc        672
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys           
    210                 215                 220                           

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        720
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
225                 230                 235                 240           

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        768
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
                245                 250                 255               

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        816
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
            260                 265                 270                   

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag        864
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
        275                 280                 285                       

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc        912
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
    290                 295                 300                           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag        960
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
305                 310                 315                 320           

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1008
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
                325                 330                 335               

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1056
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
            340                 345                 350                   

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1104
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
        355                 360                 365                       

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1152
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
    370                 375                 380                           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1200
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
385                 390                 395                 400           

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1248
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
                405                 410                 415               

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1296
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
            420                 425                 430                   

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                   1335
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
        435                 440                 445                       


<210>  86
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  87
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde avec leader 3C_23K


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  87
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc tcg agc gcc agc acc aag ggc cca tcg gtc ttc ccc        432
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
    130                 135                 140                           

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc        480
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly           
145                 150                 155                 160           

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac        528
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn           
                165                 170                 175               

tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag        576
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln           
            180                 185                 190                   

tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc        624
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser           
        195                 200                 205                       

agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc agc        672
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser           
    210                 215                 220                           

aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act        720
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr           
225                 230                 235                 240           

cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca        768
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser           
                245                 250                 255               

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg        816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg           
            260                 265                 270                   

acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct        864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro           
        275                 280                 285                       

gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc        912
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala           
    290                 295                 300                           

aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc        960
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val           
305                 310                 315                 320           

agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac       1008
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr           
                325                 330                 335               

aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc       1056
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr           
            340                 345                 350                   

atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg       1104
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu           
        355                 360                 365                       

ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc       1152
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys           
    370                 375                 380                           

ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc       1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser           
385                 390                 395                 400           

aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac       1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp           
                405                 410                 415               

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc       1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser           
            420                 425                 430                   

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct       1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala           
        435                 440                 445                       

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa       1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys           
    450                 455                 460                           


<210>  88
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  89
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde sans leader 4C_35


<220>
<221>  CDS
<222>  (1)..(1335)

<400>  89
cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga cca gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc agc agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc        432
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag        624
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc        672
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys           
    210                 215                 220                           

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        720
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
225                 230                 235                 240           

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        768
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
                245                 250                 255               

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        816
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
            260                 265                 270                   

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag        864
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
        275                 280                 285                       

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc        912
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
    290                 295                 300                           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag        960
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
305                 310                 315                 320           

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1008
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
                325                 330                 335               

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1056
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
            340                 345                 350                   

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1104
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
        355                 360                 365                       

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1152
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
    370                 375                 380                           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1200
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
385                 390                 395                 400           

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1248
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
                405                 410                 415               

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1296
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
            420                 425                 430                   

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                   1335
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
        435                 440                 445                       


<210>  90
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  91
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde avec leader 4C_35


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  91
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga cca        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc agc agc gcc agc acc aag ggc cca tcg gtc ttc ccc        432
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
    130                 135                 140                           

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc        480
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly           
145                 150                 155                 160           

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac        528
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn           
                165                 170                 175               

tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag        576
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln           
            180                 185                 190                   

tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc        624
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser           
        195                 200                 205                       

agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc agc        672
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser           
    210                 215                 220                           

aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act        720
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr           
225                 230                 235                 240           

cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca        768
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser           
                245                 250                 255               

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg        816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg           
            260                 265                 270                   

acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct        864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro           
        275                 280                 285                       

gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc        912
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala           
    290                 295                 300                           

aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc        960
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val           
305                 310                 315                 320           

agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac       1008
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr           
                325                 330                 335               

aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc       1056
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr           
            340                 345                 350                   

atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg       1104
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu           
        355                 360                 365                       

ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc       1152
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys           
    370                 375                 380                           

ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc       1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser           
385                 390                 395                 400           

aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac       1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp           
                405                 410                 415               

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc       1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser           
            420                 425                 430                   

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct       1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala           
        435                 440                 445                       

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa       1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys           
    450                 455                 460                           


<210>  92
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  93
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre sans leader 5B_42


<220>
<221>  CDS
<222>  (1)..(639)

<400>  93
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile           
            20                  25                  30                    

gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg atc tac        144
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr           
        35                  40                  45                        

cca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt        192
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac        240
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp           
65                  70                  75                  80            

gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca        288
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr           
                85                  90                  95                

ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca        336
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro           
            100                 105                 110                   

agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act        384
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr           
        115                 120                 125                       

gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa        432
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys           
    130                 135                 140                           

gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag        480
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu           
145                 150                 155                 160           

agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc        528
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser           
                165                 170                 175               

acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc        576
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala           
            180                 185                 190                   

tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc        624
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe           
        195                 200                 205                       

aac agg gga gag tgt                                                    639
Asn Arg Gly Glu Cys                                                       
    210                                                                   


<210>  94
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  95
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lgre avec leader 5B_42


<220>
<221>  CDS
<222>  (1)..(705)

<400>  95
atg gat atg aga gtg ccc gca cag ctg ctg ggt ctg ctg ctg ctg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ctg ccc gga gcc aaa tgt gac atc cag atg aca cag tcc cca tct acc         96
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr           
            20                  25                  30                    

ctg tct gct tcc gtg gga gat cgg gtg act atc acc tgc aga gca agc        144
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tcc tcc gtg agg tac atc gct tgg tac cag cag aag cca gga aag gcc        192
Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala           
    50                  55                  60                            

cca aag ctg ctg atc tac cca acc tcc tcc ctg gaa tcc ggg gtg ccc        240
Pro Lys Leu Leu Ile Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro           
65                  70                  75                  80            

agc aga ttc tca ggc agt ggc tcc ggc acc gaa ttc acc ctg acc atc        288
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
                85                  90                  95                

agc tca ctg cag cct gac gac ttc gca acc tac tac tgt ctg cag tgg        336
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp           
            100                 105                 110                   

agt agc tac cct tgg aca ttc ggc ggc ggc acc aag gtg gag atc aag        384
Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
        115                 120                 125                       

cgg acc gtc gcc gca cca agt gtc ttc atc ttc ccg cca tct gat gag        432
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
    130                 135                 140                           

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        480
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
145                 150                 155                 160           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        528
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
                165                 170                 175               

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        576
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
            180                 185                 190                   

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        624
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
        195                 200                 205                       

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        672
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
    210                 215                 220                           

ccc gtc aca aag agc ttc aac agg gga gag tgt                            705
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
225                 230                 235                               


<210>  96
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Arg Tyr Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Pro Thr Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  97
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde sans leader 5B_42


<220>
<221>  CDS
<222>  (1)..(1335)

<400>  97
cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg        144
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc        192
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe           
    50                  55                  60                            

cag ggt cgc gtg acc att acc agg gac gcc agc gcc tcc act gcc tac        240
Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc        336
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc agc agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc        432
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag        624
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc        672
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys           
    210                 215                 220                           

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        720
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
225                 230                 235                 240           

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        768
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
                245                 250                 255               

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        816
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
            260                 265                 270                   

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag        864
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
        275                 280                 285                       

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc        912
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
    290                 295                 300                           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag        960
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
305                 310                 315                 320           

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1008
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
                325                 330                 335               

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1056
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
            340                 345                 350                   

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1104
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
        355                 360                 365                       

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1152
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
    370                 375                 380                           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1200
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
385                 390                 395                 400           

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1248
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
                405                 410                 415               

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1296
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
            420                 425                 430                   

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                   1335
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
        435                 440                 445                       


<210>  98
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  99
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chane lourde avec leader 5B_42


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  99
atg gat tgg aca tgg cga atc ctg ttc ctg gtg gct gcc gca acc ggc         48
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly           
1               5                   10                  15                

gcc cac agc cag gtg cag ctg gtg cag agc ggg gcc gag gtg aag aag         96
Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct gga gcc tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc        144
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

acc agc tac cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg        192
Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu           
    50                  55                  60                            

gag tgg atg ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc        240
Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser           
65                  70                  75                  80            

cag aag ttc cag ggt cgc gtg acc att acc agg gac gcc agc gcc tcc        288
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser           
                85                  90                  95                

act gcc tac atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tac tac tgt aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act        384
Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

ctg gtg acc gtc agc agc gcc agc acc aag ggc cca tcg gtc ttc ccc        432
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
    130                 135                 140                           

ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc        480
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly           
145                 150                 155                 160           

tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac        528
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn           
                165                 170                 175               

tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag        576
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln           
            180                 185                 190                   

tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc        624
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser           
        195                 200                 205                       

agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc agc        672
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser           
    210                 215                 220                           

aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act        720
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr           
225                 230                 235                 240           

cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca        768
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser           
                245                 250                 255               

gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg        816
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg           
            260                 265                 270                   

acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct        864
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro           
        275                 280                 285                       

gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc        912
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala           
    290                 295                 300                           

aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc        960
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val           
305                 310                 315                 320           

agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac       1008
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr           
                325                 330                 335               

aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc       1056
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr           
            340                 345                 350                   

atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg       1104
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu           
        355                 360                 365                       

ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc       1152
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys           
    370                 375                 380                           

ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc       1200
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser           
385                 390                 395                 400           

aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac       1248
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp           
                405                 410                 415               

tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc       1296
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser           
            420                 425                 430                   

agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct       1344
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala           
        435                 440                 445                       

ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa       1392
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys           
    450                 455                 460                           


<210>  100
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  101
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide pitopique


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  101

Gly Gly Gly Gly Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln 
1               5                   10                  15      


Gly Ser Arg 
            


<210>  102
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide pitopique contrle ngatif


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  102

Gly Gly Gly Gly Asn Leu Thr Gln Ala Arg Gly Gln Val Glu Met Gln 
1               5                   10                  15      


Gly Ser Arg 
            


