
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN
  FRAGMENTS OF P38 MULTI-tRNA SYNTHETASE COMPLEX
  

<130> 120161.498PC

<140> PCT                 
<141> 2011-05-04  

<150> US 61/331,063       
<151> 2010-05-04  

<150> US 61/331,065       
<151> 2010-05-04  

<150> US 61/331,066       
<151> 2010-05-04  

<160> 85

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 82
<212> PRT
<213> Homo sapiens

<400> 12
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr
        


<210> 13
<211> 246
<212> DNA
<213> Homo sapiens

<400> 13
atgccgatgt accaggtaaa gccctatcac gggggcggcg cgcctctccg tgtggagctt 60
cccacctgca tgtaccggct ccccaacgtg cacggcagga gctacggccc agcgccgggc 120
gctggccacg tgcaggaaga gtctaacctg tctctgcaag ctcttgagtc ccgccaagat 180
gatattttaa aacgtctgta tgagttgaaa gctgcagttg atggcctctc caagatgatt 240
caaaca                                                            246

<210> 14
<211> 133
<212> PRT
<213> Homo sapiens

<400> 14
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
                85                  90                  95      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            100                 105                 110         
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        115                 120                 125             
Ala Ser Pro Pro Leu
    130             


<210> 15
<211> 399
<212> DNA
<213> Homo sapiens

<400> 15
atgccgatgt accaggtaaa gccctatcac gggggcggcg cgcctctccg tgtggagctt 60
cccacctgca tgtaccggct ccccaacgtg cacggcagga gctacggccc agcgccgggc 120
gctggccacg tgcaggaaga gtctaacctg tctctgcaag ctcttgagtc ccgccaagat 180
gatattttaa aacgtctgta tgagttgaaa gctgcagttg atggcctctc caagatgatt 240
caaacaccag atgcagactt ggatgtaacc aacataatcc aagcggatga gcccacgact 300
ttaaccacca atgcgctgga cttgaattca gtgcttggga aggattacgg ggcgctgaaa 360
gacatcgtga tcaacgcaaa cccggcctcc cctcccctc                        399

<210> 16
<211> 162
<212> PRT
<213> Homo sapiens

<400> 16
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
                85                  90                  95      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            100                 105                 110         
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        115                 120                 125             
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    130                 135                 140                 
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
145                 150                 155                 160 
Val Pro
        


<210> 17
<211> 486
<212> DNA
<213> Homo sapiens

<400> 17
atgccgatgt accaggtaaa gccctatcac gggggcggcg cgcctctccg tgtggagctt 60
cccacctgca tgtaccggct ccccaacgtg cacggcagga gctacggccc agcgccgggc 120
gctggccacg tgcaggaaga gtctaacctg tctctgcaag ctcttgagtc ccgccaagat 180
gatattttaa aacgtctgta tgagttgaaa gctgcagttg atggcctctc caagatgatt 240
caaacaccag atgcagactt ggatgtaacc aacataatcc aagcggatga gcccacgact 300
ttaaccacca atgcgctgga cttgaattca gtgcttggga aggattacgg ggcgctgaaa 360
gacatcgtga tcaacgcaaa cccggcctcc cctcccctct ccctgcttgt gctgcacagg 420
ctgctctgtg agcacttcag ggtcctgtcc acggtgcaca cgcactcctc ggtcaagagc 480
gtgcct                                                            486

<210> 18
<211> 231
<212> PRT
<213> Homo sapiens

<400> 18
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
                85                  90                  95      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            100                 105                 110         
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        115                 120                 125             
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    130                 135                 140                 
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
145                 150                 155                 160 
Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln
                165                 170                 175     
Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val
            180                 185                 190         
Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu
        195                 200                 205             
Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys
    210                 215                 220                 
His Asn Ala Val Asn Ala Thr
225                 230     


<210> 19
<211> 693
<212> DNA
<213> Homo sapiens

<400> 19
atgccgatgt accaggtaaa gccctatcac gggggcggcg cgcctctccg tgtggagctt 60
cccacctgca tgtaccggct ccccaacgtg cacggcagga gctacggccc agcgccgggc 120
gctggccacg tgcaggaaga gtctaacctg tctctgcaag ctcttgagtc ccgccaagat 180
gatattttaa aacgtctgta tgagttgaaa gctgcagttg atggcctctc caagatgatt 240
caaacaccag atgcagactt ggatgtaacc aacataatcc aagcggatga gcccacgact 300
ttaaccacca atgcgctgga cttgaattca gtgcttggga aggattacgg ggcgctgaaa 360
gacatcgtga tcaacgcaaa cccggcctcc cctcccctct ccctgcttgt gctgcacagg 420
ctgctctgtg agcacttcag ggtcctgtcc acggtgcaca cgcactcctc ggtcaagagc 480
gtgcctgaaa accttctcaa gtgctttgga gaacagaata aaaaacagcc ccgccaagac 540
tatcagctgg gattcacttt aatttggaag aatgtgccga agacgcagat gaaattcagc 600
atccagacga tgtgccccat cgaaggcgaa gggaacattg cacgtttctt gttctctctg 660
tttggccaga agcataatgc tgtcaacgca acc                              693

<210> 20
<211> 102
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      

<400> 20
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly
            20                  25                  30          
Gly Ala Pro Leu Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro
        35                  40                  45              
Asn Val His Gly Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val
    50                  55                  60                  
Gln Glu Glu Ser Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp
65                  70                  75                  80  
Asp Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu
                85                  90                  95      
Ser Lys Met Ile Gln Thr
            100         


<210> 21
<211> 102
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      

<400> 21
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
                85                  90                  95      
His His His His His His
            100         


<210> 22
<211> 153
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      

<400> 22
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly
            20                  25                  30          
Gly Ala Pro Leu Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro
        35                  40                  45              
Asn Val His Gly Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val
    50                  55                  60                  
Gln Glu Glu Ser Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp
65                  70                  75                  80  
Asp Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu
                85                  90                  95      
Ser Lys Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile
            100                 105                 110         
Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu
        115                 120                 125             
Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile
    130                 135                 140                 
Asn Ala Asn Pro Ala Ser Pro Pro Leu
145                 150             


<210> 23
<211> 153
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      

<400> 23
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
                85                  90                  95      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            100                 105                 110         
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        115                 120                 125             
Ala Ser Pro Pro Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
    130                 135                 140                 
Asp Ser Thr His His His His His His
145                 150             


<210> 24
<211> 182
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      

<400> 24
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly
            20                  25                  30          
Gly Ala Pro Leu Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro
        35                  40                  45              
Asn Val His Gly Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val
    50                  55                  60                  
Gln Glu Glu Ser Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp
65                  70                  75                  80  
Asp Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu
                85                  90                  95      
Ser Lys Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile
            100                 105                 110         
Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu
        115                 120                 125             
Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile
    130                 135                 140                 
Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
145                 150                 155                 160 
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
                165                 170                 175     
Ser Val Lys Ser Val Pro
            180         


<210> 25
<211> 182
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      

<400> 25
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
                85                  90                  95      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            100                 105                 110         
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        115                 120                 125             
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    130                 135                 140                 
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
145                 150                 155                 160 
Val Pro Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
                165                 170                 175     
His His His His His His
            180         


<210> 26
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      

<400> 26
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly
            20                  25                  30          
Gly Ala Pro Leu Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro
        35                  40                  45              
Asn Val His Gly Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val
    50                  55                  60                  
Gln Glu Glu Ser Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp
65                  70                  75                  80  
Asp Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu
                85                  90                  95      
Ser Lys Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile
            100                 105                 110         
Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu
        115                 120                 125             
Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile
    130                 135                 140                 
Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
145                 150                 155                 160 
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
                165                 170                 175     
Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln
            180                 185                 190         
Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile
        195                 200                 205             
Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met
    210                 215                 220                 
Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu
225                 230                 235                 240 
Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr
                245                 250     


<210> 27
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      

<400> 27
Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu
 1               5                  10                  15      
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly
            20                  25                  30          
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser
        35                  40                  45              
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
    50                  55                  60                  
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
65                  70                  75                  80  
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
                85                  90                  95      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            100                 105                 110         
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        115                 120                 125             
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    130                 135                 140                 
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
145                 150                 155                 160 
Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln
                165                 170                 175     
Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val
            180                 185                 190         
Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu
        195                 200                 205             
Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys
    210                 215                 220                 
His Asn Ala Val Asn Ala Thr Gly Lys Pro Ile Pro Asn Pro Leu Leu
225                 230                 235                 240 
Gly Leu Asp Ser Thr His His His His His His
                245                 250     


<210> 28
<211> 255
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      

<400> 28
ccaatgtacc aagtcaaacc ataccacggc ggcggcgcac cactgcgtgt cgagctgccg 60
acctgcatgt accgtctgcc taacgtgcat ggtcgcagct atggtccggc cccgggcgcg 120
ggtcacgttc aagaagaaag caatctgagc ctgcaagctc tggagtctcg tcaggacgac 180
attttgaaac gcctgtacga gttgaaggca gcggttgatg gcctgagcaa gatgatccag 240
acgtaatgac tcgag                                                  255

<210> 29
<211> 408
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      

<400> 29
ccaatgtacc aagtcaaacc ataccacggc ggcggcgcac cactgcgtgt cgagctgccg 60
acgtgcatgt atcgtctgcc gaacgtgcac ggccgcagct acggtccagc cccgggtgca 120
ggccatgttc aagaagagag caacctgtcc ctgcaggctc tggagagccg tcaagacgat 180
attttgaagc gcctgtacga actgaaggcg gctgtcgacg gtctgtcgaa gatgatccag 240
acgccggatg cggatctgga cgttaccaac attatccagg cggatgaacc gactaccttg 300
accaccaatg cgctggactt gaatagcgtg ctgggtaaag attatggcgc cctgaaagac 360
atcgttatta acgcaaatcc ggcgagccct ccgctgtaat gactcgag              408

<210> 30
<211> 495
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      

<400> 30
ccaatgtacc aagtcaaacc ataccacggc ggcggcgcac cactgcgcgt tgaactgccg 60
acctgtatgt accgcctgcc gaatgtgcac ggccgttctt atggtccagc gccgggtgcc 120
ggtcacgtgc aagaagagag caatttgtcc ctgcaggcgc tggagagccg tcaagatgat 180
atcctgaagc gtctgtatga gttgaaggca gcggttgacg gcttgagcaa aatgatccag 240
accccggatg cggatctgga cgtcaccaac attattcagg ctgacgaacc tacgaccctg 300
acgacgaatg ccctggacct gaacagcgtc ctgggtaagg actacggcgc actgaaagat 360
atcgttatta acgcgaaccc ggcttccccg ccgttgtcgt tgctggtgct gcaccgtctg 420
ctgtgcgagc acttccgtgt gctgagcacc gttcatactc atagcagcgt caaaagcgtc 480
ccgtaatgac tcgag                                                  495

<210> 31
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      

<400> 31
ccaatgtacc aagtcaaacc ataccacggc ggcggcgcac cactgcgcgt tgaactgccg 60
acgtgtatgt atcgtttgcc gaacgttcat ggccgcagct acggtccggc gccaggtgcg 120
ggtcacgttc aagaagagag caacctgtct ctgcaggcgc tggagtcccg tcaggatgat 180
attctgaagc gtctgtatga actgaaggct gcagtggacg gcctgagcaa aatgattcag 240
acgccggacg cggatctgga cgttacgaac atcatccaag cagacgaacc gaccaccctg 300
accaccaatg cgttggacct gaatagcgtg ctgggcaaag attacggtgc tctgaaggat 360
attgtgatta acgccaatcc ggccagccct ccattgagcc tgctggtcct gcaccgtctg 420
ctgtgcgagc attttcgtgt tttgagcacc gtccatacgc acagctccgt gaaatcggtg 480
ccggaaaact tgctgaaatg ttttggtgag caaaacaaga aacagccgcg tcaggactac 540
caactgggct tcacgctgat ttggaagaat gtccctaaga cccaaatgaa attcagcatc 600
cagaccatgt gcccgatcga gggtgagggc aacatcgcgc gcttcctgtt ctctctgttt 660
ggtcagaaac acaatgccgt caatgcaact taatgactcg ag                    702

<210> 32
<211> 239
<212> PRT
<213> Homo sapiens

<400> 32
Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp Glu
 1               5                  10                  15      
Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu Gly
            20                  25                  30          
Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala
        35                  40                  45              
Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His
    50                  55                  60                  
Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val
65                  70                  75                  80  
Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro
                85                  90                  95      
Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro
            100                 105                 110         
Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly
        115                 120                 125             
Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His
    130                 135                 140                 
Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile
145                 150                 155                 160 
Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg
                165                 170                 175     
Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu
            180                 185                 190         
Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly
        195                 200                 205             
Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser
    210                 215                 220                 
Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys
225                 230                 235                 


<210> 33
<211> 720
<212> DNA
<213> Homo sapiens

<400> 33
acaccagatg cagacttgga tgtaaccaac ataatccaag cggatgagcc cacgacttta 60
accaccaatg cgctggactt gaattcagtg cttgggaagg attacggggc gctgaaagac 120
atcgtgatca acgcaaaccc ggcctcccct cccctctccc tgcttgtgct gcacaggctg 180
ctctgtgagc acttcagggt cctgtccacg gtgcacacgc actcctcggt caagagcgtg 240
cctgaaaacc ttctcaagtg ctttggagaa cagaataaaa aacagccccg ccaagactat 300
cagctgggat tcactttaat ttggaagaat gtgccgaaga cgcagatgaa attcagcatc 360
cagacgatgt gccccatcga aggcgaaggg aacattgcac gtttcttgtt ctctctgttt 420
ggccagaagc ataatgctgt caacgcaacc cttatagata gctgggtaga tattgcgatt 480
tttcagttaa aagagggaag cagtaaagaa aaagccgctg ttttccgctc catgaactct 540
gctcttggga agagcccttg gctcgctggg aatgaactca ccgtagcaga cgtggtgctg 600
tggtctgtac tccagcagat cggaggctgc agtgtgacag tgccagccaa tgtgcagagg 660
tggatgaggt cttgtgaaaa cctggctcct tttaacacgg ccctcaagct ccttaagtga 720


<210> 34
<211> 17
<212> PRT
<213> Mus musculus

<400> 34
Phe Ser Val Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala
 1               5                  10                  15      
Arg
    


<210> 35
<211> 89
<212> PRT
<213> Mus musculus

<400> 35
Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Thr Leu Thr
 1               5                  10                  15      
Leu Ile Asp Ser Trp Val Asp Ile Ala Met Phe Gln Leu Arg Glu Gly
            20                  25                  30          
Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu
        35                  40                  45              
Gly Arg Ser Pro Trp Leu Val Gly Asn Glu Leu Thr Val Ala Asp Val
    50                  55                  60                  
Val Leu Trp Ser Val Leu Gln Gln Thr Gly Gly Ser Ser Gly Ala Ala
65                  70                  75                  80  
Pro Thr Asn Val Gln Arg Trp Leu Lys
                85                  


<210> 36
<211> 16
<212> PRT
<213> Mus musculus

<400> 36
Ser Cys Glu Asn Leu Ala Pro Phe Ser Thr Ala Leu Gln Leu Leu Lys
 1               5                  10                  15      


<210> 37
<211> 122
<212> PRT
<213> Mus musculus

<400> 37
Phe Ser Val Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala
 1               5                  10                  15      
Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Thr Leu
            20                  25                  30          
Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Met Phe Gln Leu Arg Glu
        35                  40                  45              
Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala
    50                  55                  60                  
Leu Gly Arg Ser Pro Trp Leu Val Gly Asn Glu Leu Thr Val Ala Asp
65                  70                  75                  80  
Val Val Leu Trp Ser Val Leu Gln Gln Thr Gly Gly Ser Ser Gly Ala
                85                  90                  95      
Ala Pro Thr Asn Val Gln Arg Trp Leu Lys Ser Cys Glu Asn Leu Ala
            100                 105                 110         
Pro Phe Ser Thr Ala Leu Gln Leu Leu Lys
        115                 120         


<210> 38
<211> 195
<212> PRT
<213> Homo sapiens

<400> 38
Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu
 1               5                  10                  15      
Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser
            20                  25                  30          
Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn
        35                  40                  45              
Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp
    50                  55                  60                  
Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys
65                  70                  75                  80  
Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe
                85                  90                  95      
Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val
            100                 105                 110         
Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala
        115                 120                 125             
Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu
    130                 135                 140                 
Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu
145                 150                 155                 160 
Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg
                165                 170                 175     
Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys
            180                 185                 190         
Leu Leu Lys
        195 


<210> 39
<211> 588
<212> DNA
<213> Homo sapiens

<400> 39
gcaaacccgg cctcccctcc cctctccctg cttgtgctgc acaggctgct ctgtgagcac 60
ttcagggtcc tgtccacggt gcacacgcac tcctcggtca agagcgtgcc tgaaaacctt 120
ctcaagtgct ttggagaaca gaataaaaaa cagccccgcc aagactatca gctgggattc 180
actttaattt ggaagaatgt gccgaagacg cagatgaaat tcagcatcca gacgatgtgc 240
cccatcgaag gcgaagggaa cattgcacgt ttcttgttct ctctgtttgg ccagaagcat 300
aatgctgtca acgcaaccct tatagatagc tgggtagata ttgcgatttt tcagttaaaa 360
gagggaagca gtaaagaaaa agccgctgtt ttccgctcca tgaactctgc tcttgggaag 420
agcccttggc tcgctgggaa tgaactcacc gtagcagacg tggtgctgtg gtctgtactc 480
cagcagatcg gaggctgcag tgtgacagtg ccagccaatg tgcagaggtg gatgaggtct 540
tgtgaaaacc tggctccttt taacacggcc ctcaagctcc ttaagtga              588

<210> 40
<211> 165
<212> PRT
<213> Homo sapiens

<400> 40
Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu
 1               5                  10                  15      
Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu
            20                  25                  30          
Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr
        35                  40                  45              
Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser
    50                  55                  60                  
Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser
65                  70                  75                  80  
Trp Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu
                85                  90                  95      
Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro
            100                 105                 110         
Trp Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser
        115                 120                 125             
Val Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val
    130                 135                 140                 
Gln Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala
145                 150                 155                 160 
Leu Lys Leu Leu Lys
                165 


<210> 41
<211> 498
<212> DNA
<213> Homo sapiens

<400> 41
tcctcggtca agagcgtgcc tgaaaacctt ctcaagtgct ttggagaaca gaataaaaaa 60
cagccccgcc aagactatca gctgggattc actttaattt ggaagaatgt gccgaagacg 120
cagatgaaat tcagcatcca gacgatgtgc cccatcgaag gcgaagggaa cattgcacgt 180
ttcttgttct ctctgtttgg ccagaagcat aatgctgtca acgcaaccct tatagatagc 240
tgggtagata ttgcgatttt tcagttaaaa gagggaagca gtaaagaaaa agccgctgtt 300
ttccgctcca tgaactctgc tcttgggaag agcccttggc tcgctgggaa tgaactcacc 360
gtagcagacg tggtgctgtg gtctgtactc cagcagatcg gaggctgcag tgtgacagtg 420
ccagccaatg tgcagaggtg gatgaggtct tgtgaaaacc tggctccttt taacacggcc 480
ctcaagctcc ttaagtga                                               498

<210> 42
<211> 100
<212> PRT
<213> Homo sapiens

<400> 42
Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp
 1               5                  10                  15      
Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys
            20                  25                  30          
Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp
        35                  40                  45              
Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val
    50                  55                  60                  
Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln
65                  70                  75                  80  
Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu
                85                  90                  95      
Lys Leu Leu Lys
            100 


<210> 43
<211> 303
<212> DNA
<213> Homo sapiens

<400> 43
tttggccaga agcataatgc tgtcaacgca acccttatag atagctgggt agatattgcg 60
atttttcagt taaaagaggg aagcagtaaa gaaaaagccg ctgttttccg ctccatgaac 120
tctgctcttg ggaagagccc ttggctcgct gggaatgaac tcaccgtagc agacgtggtg 180
ctgtggtctg tactccagca gatcggaggc tgcagtgtga cagtgccagc caatgtgcag 240
aggtggatga ggtcttgtga aaacctggct ccttttaaca cggccctcaa gctccttaag 300
tga                                                               303

<210> 44
<211> 260
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      

<400> 44
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile
            20                  25                  30          
Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu
        35                  40                  45              
Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile
    50                  55                  60                  
Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
65                  70                  75                  80  
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
                85                  90                  95      
Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln
            100                 105                 110         
Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile
        115                 120                 125             
Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met
    130                 135                 140                 
Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu
145                 150                 155                 160 
Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp
                165                 170                 175     
Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys
            180                 185                 190         
Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp
        195                 200                 205             
Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val
    210                 215                 220                 
Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln
225                 230                 235                 240 
Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu
                245                 250                 255     
Lys Leu Leu Lys
            260 


<210> 45
<211> 260
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      

<400> 45
Met Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
 1               5                  10                  15      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            20                  25                  30          
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        35                  40                  45              
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    50                  55                  60                  
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
65                  70                  75                  80  
Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln
                85                  90                  95      
Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val
            100                 105                 110         
Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu
        115                 120                 125             
Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys
    130                 135                 140                 
His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala
145                 150                 155                 160 
Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe
                165                 170                 175     
Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn
            180                 185                 190         
Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile
        195                 200                 205             
Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg
    210                 215                 220                 
Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys
225                 230                 235                 240 
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
                245                 250                 255     
His His His His
            260 


<210> 46
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      

<400> 46
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu
            20                  25                  30          
Val Leu His Arg Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val
        35                  40                  45              
His Thr His Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys
    50                  55                  60                  
Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly
65                  70                  75                  80  
Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser
                85                  90                  95      
Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe
            100                 105                 110         
Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu
        115                 120                 125             
Ile Asp Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser
    130                 135                 140                 
Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly
145                 150                 155                 160 
Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val
                165                 170                 175     
Leu Trp Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro
            180                 185                 190         
Ala Asn Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe
        195                 200                 205             
Asn Thr Ala Leu Lys Leu Leu Lys
    210                 215     


<210> 47
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      

<400> 47
Met Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
 1               5                  10                  15      
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
            20                  25                  30          
Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln
        35                  40                  45              
Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile
    50                  55                  60                  
Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met
65                  70                  75                  80  
Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu
                85                  90                  95      
Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp
            100                 105                 110         
Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys
        115                 120                 125             
Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp
    130                 135                 140                 
Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val
145                 150                 155                 160 
Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln
                165                 170                 175     
Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu
            180                 185                 190         
Lys Leu Leu Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
        195                 200                 205             
Ser Thr His His His His His His
    210                 215     


<210> 48
<211> 186
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      

<400> 48
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu
            20                  25                  30          
Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln
        35                  40                  45              
Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys
    50                  55                  60                  
Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala
65                  70                  75                  80  
Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala
                85                  90                  95      
Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys Glu
            100                 105                 110         
Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala
        115                 120                 125             
Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala Asp
    130                 135                 140                 
Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val Thr
145                 150                 155                 160 
Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu Ala
                165                 170                 175     
Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys
            180                 185     


<210> 49
<211> 186
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      

<400> 49
Met Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly
 1               5                  10                  15      
Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr
            20                  25                  30          
Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln
        35                  40                  45              
Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe
    50                  55                  60                  
Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp
65                  70                  75                  80  
Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys
                85                  90                  95      
Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser
            100                 105                 110         
Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp
        115                 120                 125             
Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn
    130                 135                 140                 
Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr
145                 150                 155                 160 
Ala Leu Lys Leu Leu Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                165                 170                 175     
Leu Asp Ser Thr His His His His His His
            180                 185     


<210> 50
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      

<400> 50
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr
            20                  25                  30          
Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly
        35                  40                  45              
Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu
    50                  55                  60                  
Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val
65                  70                  75                  80  
Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val
                85                  90                  95      
Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro
            100                 105                 110         
Phe Asn Thr Ala Leu Lys Leu Leu Lys
        115                 120     


<210> 51
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      

<400> 51
Met Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser
 1               5                  10                  15      
Trp Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu
            20                  25                  30          
Lys Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro
        35                  40                  45              
Trp Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser
    50                  55                  60                  
Val Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val
65                  70                  75                  80  
Gln Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala
                85                  90                  95      
Leu Lys Leu Leu Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
            100                 105                 110         
Asp Ser Thr His His His His His His
        115                 120     


<210> 52
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      

<400> 52
acccctgacg cagatctgga cgtaacgaac atcattcaag cggacgagcc gaccactctg 60
accaccaacg cgctggacct gaatagcgtc ctgggtaagg attacggtgc gctgaaagac 120
atcgttatta acgcaaaccc ggcaagccct ccgctgtcgc tgctggtgct gcaccgtctg 180
ctgtgcgaac actttcgtgt tctgagcacg gtccacaccc atagctccgt gaagtctgtt 240
ccggaaaatc tgctgaaatg cttcggcgag cagaataaga aacagccacg ccaggattat 300
caactgggtt tcacgctgat ctggaagaac gttccgaaaa cgcaaatgaa gttttctatt 360
caaaccatgt gtccgatcga gggcgaaggc aatatcgctc gcttcttgtt cagcttgttc 420
ggccagaagc ataacgcggt caatgctacc ctgattgata gctgggtcga cattgcgatt 480
ttccaactga aagagggtag cagcaaagag aaagcggccg tgtttcgtag catgaatagc 540
gccctgggca agagcccgtg gttggccggt aatgagttga ccgtcgctga tgtggtgctg 600
tggtccgtct tgcaacagat cggtggttgc tccgttacgg tgccggcaaa cgttcagcgt 660
tggatgcgca gctgtgaaaa cctggcgccg tttaacacgg cgctgaagct gctgaaataa 720
tgactcgag                                                         729

<210> 53
<211> 597
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      

<400> 53
gcaaaccctg cgagcccacc actgagcctg ttggttctgc accgcttgtt gtgcgagcac 60
ttccgcgtgc tgagcaccgt tcatacccac agcagcgtga agtccgtccc ggaaaacctg 120
ctgaaatgtt tcggtgagca gaataagaag caaccgcgtc aggactacca gttgggtttt 180
accctgatct ggaagaacgt gcctaaaacg cagatgaaat ttagcatcca aaccatgtgt 240
ccgattgagg gcgaaggtaa cattgcacgt ttcctgttct ctctgtttgg ccagaagcat 300
aacgcagtga acgcgactct gatcgatagc tgggtcgata ttgccatctt tcaactgaaa 360
gaaggtagca gcaaagagaa agcggctgtc tttcgttcca tgaatagcgc gctgggcaaa 420
agcccgtggc tggccggcaa tgagctgacc gtcgcagacg tggtcctgtg gagcgttctg 480
cagcaaattg gtggttgctc ggttacggtt ccggcgaatg ttcaacgttg gatgcgctct 540
tgcgaaaacc tggcgccatt caatacggct ctgaagctgc tgaaataatg actcgag    597

<210> 54
<211> 507
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      

<400> 54
tcgtccgtca aatccgtccc tgagaacctg ctgaaatgct tcggtgaaca aaataagaag 60
caaccgcgtc aagattacca gttgggtttc accctgatct ggaagaacgt cccgaaaacg 120
caaatgaaat tttctatcca gaccatgtgc ccgattgaag gcgagggtaa cattgcccgc 180
ttcctgttta gcctgtttgg ccagaaacac aatgcggtca atgctacgct gatcgactcg 240
tgggttgata ttgcgatttt ccagttgaaa gaaggtagca gcaaagagaa ggcggcagtg 300
ttccgttcca tgaacagcgc actgggtaag agcccgtggc tggcgggtaa tgagctgacc 360
gtggccgacg ttgtgctgtg gagcgtcctg caacagatcg gcggctgctc cgttaccgtg 420
ccagccaatg ttcagcgttg gatgcgcagc tgtgagaacc tggcgccgtt taacactgca 480
ttgaaactgc tgaagtaatg actcgag                                     507

<210> 55
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      

<400> 55
ttcggccaaa agcacaacgc agtaaacgcc accctgatcg actcttgggt tgacatcgcg 60
attttccagc tgaaagaggg ttccagcaaa gagaaggcag cagtgtttcg tagcatgaat 120
agcgcactgg gtaagagccc gtggctggcg ggtaacgaac tgaccgttgc cgatgtggtt 180
ctgtggagcg tcttgcagca aatcggcggc tgttccgtca cggtcccggc taacgtgcaa 240
cgctggatgc gtagctgcga aaacttggcg ccgttcaata ccgcgctgaa gctgctgaaa 300
taatgactcg ag                                                     312

<210> 56
<211> 114
<212> PRT
<213> Homo sapiens

<400> 56
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
 1               5                  10                  15      
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
            20                  25                  30          
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
        35                  40                  45              
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
    50                  55                  60                  
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
65                  70                  75                  80  
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
                85                  90                  95      
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
            100                 105                 110         
Val Pro
        


<210> 57
<211> 342
<212> DNA
<213> Homo sapiens

<400> 57
aacctgtctc tgcaagctct tgagtcccgc caagatgata ttttaaaacg tctgtatgag 60
ttgaaagctg cagttgatgg cctctccaag atgattcaaa caccagatgc agacttggat 120
gtaaccaaca taatccaagc ggatgagccc acgactttaa ccaccaatgc gctggacttg 180
aattcagtgc ttgggaagga ttacggggcg ctgaaagaca tcgtgatcaa cgcaaacccg 240
gcctcccctc ccctctccct gcttgtgctg cacaggctgc tctgtgagca cttcagggtc 300
ctgtccacgg tgcacacgca ctcctcggtc aagagcgtgc ct                    342

<210> 58
<211> 81
<212> PRT
<213> Homo sapiens

<400> 58
Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp Glu
 1               5                  10                  15      
Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu Gly
            20                  25                  30          
Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala
        35                  40                  45              
Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His
    50                  55                  60                  
Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val
65                  70                  75                  80  
Pro
    


<210> 59
<211> 243
<212> DNA
<213> Homo sapiens

<400> 59
acaccagatg cagacttgga tgtaaccaac ataatccaag cggatgagcc cacgacttta 60
accaccaatg cgctggactt gaattcagtg cttgggaagg attacggggc gctgaaagac 120
atcgtgatca acgcaaaccc ggcctcccct cccctctccc tgcttgtgct gcacaggctg 180
ctctgtgagc acttcagggt cctgtccacg gtgcacacgc actcctcggt caagagcgtg 240
cct                                                               243

<210> 60
<211> 183
<212> PRT
<213> Homo sapiens

<400> 60
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys
 1               5                  10                  15      
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile
            20                  25                  30          
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
        35                  40                  45              
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
    50                  55                  60                  
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
65                  70                  75                  80  
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
                85                  90                  95      
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
            100                 105                 110         
Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln
        115                 120                 125             
Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val
    130                 135                 140                 
Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu
145                 150                 155                 160 
Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys
                165                 170                 175     
His Asn Ala Val Asn Ala Thr
            180             


<210> 61
<211> 549
<212> DNA
<213> Homo sapiens

<400> 61
aacctgtctc tgcaagctct tgagtcccgc caagatgata ttttaaaacg tctgtatgag 60
ttgaaagctg cagttgatgg cctctccaag atgattcaaa caccagatgc agacttggat 120
gtaaccaaca taatccaagc ggatgagccc acgactttaa ccaccaatgc gctggacttg 180
aattcagtgc ttgggaagga ttacggggcg ctgaaagaca tcgtgatcaa cgcaaacccg 240
gcctcccctc ccctctccct gcttgtgctg cacaggctgc tctgtgagca cttcagggtc 300
ctgtccacgg tgcacacgca ctcctcggtc aagagcgtgc ctgaaaacct tctcaagtgc 360
tttggagaac agaataaaaa acagccccgc caagactatc agctgggatt cactttaatt 420
tggaagaatg tgccgaagac gcagatgaaa ttcagcatcc agacgatgtg ccccatcgaa 480
ggcgaaggga acattgcacg tttcttgttc tctctgtttg gccagaagca taatgctgtc 540
aacgcaacc                                                         549

<210> 62
<211> 150
<212> PRT
<213> Homo sapiens

<400> 62
Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp Glu
 1               5                  10                  15      
Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu Gly
            20                  25                  30          
Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala
        35                  40                  45              
Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His
    50                  55                  60                  
Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val
65                  70                  75                  80  
Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro
                85                  90                  95      
Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro
            100                 105                 110         
Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly
        115                 120                 125             
Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His
    130                 135                 140                 
Asn Ala Val Asn Ala Thr
145                 150 


<210> 63
<211> 450
<212> DNA
<213> Homo sapiens

<400> 63
acaccagatg cagacttgga tgtaaccaac ataatccaag cggatgagcc cacgacttta 60
accaccaatg cgctggactt gaattcagtg cttgggaagg attacggggc gctgaaagac 120
atcgtgatca acgcaaaccc ggcctcccct cccctctccc tgcttgtgct gcacaggctg 180
ctctgtgagc acttcagggt cctgtccacg gtgcacacgc actcctcggt caagagcgtg 240
cctgaaaacc ttctcaagtg ctttggagaa cagaataaaa aacagccccg ccaagactat 300
cagctgggat tcactttaat ttggaagaat gtgccgaaga cgcagatgaa attcagcatc 360
cagacgatgt gccccatcga aggcgaaggg aacattgcac gtttcttgtt ctctctgttt 420
ggccagaagc ataatgctgt caacgcaacc                                  450

<210> 64
<211> 106
<212> PRT
<213> Homo sapiens

<400> 64
Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu
 1               5                  10                  15      
Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser
            20                  25                  30          
Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn
        35                  40                  45              
Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp
    50                  55                  60                  
Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys
65                  70                  75                  80  
Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe
                85                  90                  95      
Gly Gln Lys His Asn Ala Val Asn Ala Thr
            100                 105     


<210> 65
<211> 318
<212> DNA
<213> Homo sapiens

<400> 65
gcaaacccgg cctcccctcc cctctccctg cttgtgctgc acaggctgct ctgtgagcac 60
ttcagggtcc tgtccacggt gcacacgcac tcctcggtca agagcgtgcc tgaaaacctt 120
ctcaagtgct ttggagaaca gaataaaaaa cagccccgcc aagactatca gctgggattc 180
actttaattt ggaagaatgt gccgaagacg cagatgaaat tcagcatcca gacgatgtgc 240
cccatcgaag gcgaagggaa cattgcacgt ttcttgttct ctctgtttgg ccagaagcat 300
aatgctgtca acgcaacc                                               318

<210> 66
<211> 76
<212> PRT
<213> Homo sapiens

<400> 66
Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu
 1               5                  10                  15      
Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu
            20                  25                  30          
Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr
        35                  40                  45              
Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser
    50                  55                  60                  
Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr
65                  70                  75      


<210> 67
<211> 228
<212> DNA
<213> Homo sapiens

<400> 67
tcctcggtca agagcgtgcc tgaaaacctt ctcaagtgct ttggagaaca gaataaaaaa 60
cagccccgcc aagactatca gctgggattc actttaattt ggaagaatgt gccgaagacg 120
cagatgaaat tcagcatcca gacgatgtgc cccatcgaag gcgaagggaa cattgcacgt 180
ttcttgttct ctctgtttgg ccagaagcat aatgctgtca acgcaacc              228

<210> 68
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      
      
      

<400> 68
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln
            20                  25                  30          
Asp Asp Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly
        35                  40                  45              
Leu Ser Lys Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn
    50                  55                  60                  
Ile Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp
65                  70                  75                  80  
Leu Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val
                85                  90                  95      
Ile Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His
            100                 105                 110         
Arg Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His
        115                 120                 125             
Ser Ser Val Lys Ser Val Pro
    130                 135 


<210> 69
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      
      
      

<400> 69
Met Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu
 1               5                  10                  15      
Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met
            20                  25                  30          
Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala
        35                  40                  45              
Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val
    50                  55                  60                  
Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn
65                  70                  75                  80  
Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys
                85                  90                  95      
Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys
            100                 105                 110         
Ser Val Pro Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
        115                 120                 125             
Thr His His His His His His
    130                 135 


<210> 70
<211> 102
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      
      
      

<400> 70
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile
            20                  25                  30          
Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu
        35                  40                  45              
Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile
    50                  55                  60                  
Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
65                  70                  75                  80  
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
                85                  90                  95      
Ser Val Lys Ser Val Pro
            100         


<210> 71
<211> 102
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      
      
      

<400> 71
Met Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
 1               5                  10                  15      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            20                  25                  30          
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        35                  40                  45              
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    50                  55                  60                  
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
65                  70                  75                  80  
Val Pro Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
                85                  90                  95      
His His His His His His
            100         


<210> 72
<211> 204
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      
      
      

<400> 72
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln
            20                  25                  30          
Asp Asp Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly
        35                  40                  45              
Leu Ser Lys Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn
    50                  55                  60                  
Ile Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp
65                  70                  75                  80  
Leu Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val
                85                  90                  95      
Ile Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His
            100                 105                 110         
Arg Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His
        115                 120                 125             
Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu
    130                 135                 140                 
Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu
145                 150                 155                 160 
Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr
                165                 170                 175     
Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser
            180                 185                 190         
Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr
        195                 200                 


<210> 73
<211> 204
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      
      
      

<400> 73
Met Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu
 1               5                  10                  15      
Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met
            20                  25                  30          
Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala
        35                  40                  45              
Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val
    50                  55                  60                  
Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn
65                  70                  75                  80  
Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys
                85                  90                  95      
Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys
            100                 105                 110         
Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys
        115                 120                 125             
Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn
    130                 135                 140                 
Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile
145                 150                 155                 160 
Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln
                165                 170                 175     
Lys His Asn Ala Val Asn Ala Thr Gly Lys Pro Ile Pro Asn Pro Leu
            180                 185                 190         
Leu Gly Leu Asp Ser Thr His His His His His His
        195                 200                 


<210> 74
<211> 171
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      
      
      

<400> 74
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile
            20                  25                  30          
Ile Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu
        35                  40                  45              
Asn Ser Val Leu Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile
    50                  55                  60                  
Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
65                  70                  75                  80  
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
                85                  90                  95      
Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln
            100                 105                 110         
Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile
        115                 120                 125             
Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met
    130                 135                 140                 
Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu
145                 150                 155                 160 
Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr
                165                 170     


<210> 75
<211> 171
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      
      
      

<400> 75
Met Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp
 1               5                  10                  15      
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu
            20                  25                  30          
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro
        35                  40                  45              
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu
    50                  55                  60                  
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser
65                  70                  75                  80  
Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln
                85                  90                  95      
Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val
            100                 105                 110         
Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu
        115                 120                 125             
Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys
    130                 135                 140                 
His Asn Ala Val Asn Ala Thr Gly Lys Pro Ile Pro Asn Pro Leu Leu
145                 150                 155                 160 
Gly Leu Asp Ser Thr His His His His His His
                165                 170     


<210> 76
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      
      
      

<400> 76
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu
            20                  25                  30          
Val Leu His Arg Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val
        35                  40                  45              
His Thr His Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys
    50                  55                  60                  
Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly
65                  70                  75                  80  
Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser
                85                  90                  95      
Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe
            100                 105                 110         
Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr
        115                 120                 125         


<210> 77
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      
      
      

<400> 77
Met Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg
 1               5                  10                  15      
Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser
            20                  25                  30          
Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln
        35                  40                  45              
Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile
    50                  55                  60                  
Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met
65                  70                  75                  80  
Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu
                85                  90                  95      
Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Gly Lys Pro Ile Pro
            100                 105                 110         
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
        115                 120                 125         


<210> 78
<211> 97
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with N-terminal 6xHis affinity tag
      
      
      
      
      

<400> 78
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu
            20                  25                  30          
Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln
        35                  40                  45              
Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys
    50                  55                  60                  
Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala
65                  70                  75                  80  
Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala
                85                  90                  95      
Thr
    


<210> 79
<211> 97
<212> PRT
<213> Artificial Sequence

<220> 
<223> P38 from the multi-tRNA synthetase complex
      polypeptide with C-terminal 6xHis affinity tag
      
      
      
      
      

<400> 79
Met Ser Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly
 1               5                  10                  15      
Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr
            20                  25                  30          
Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln
        35                  40                  45              
Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe
    50                  55                  60                  
Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Gly Lys Pro
65                  70                  75                  80  
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
                85                  90                  95      
His
    


<210> 80
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      
      
      

<400> 80
aacctgagcc tgcaagcact ggagagccgc caagacgaca tcctgaagcg tctgtatgag 60
ctgaaagcag cagtcgacgg cctgagcaag atgatccaaa cgccagatgc cgacttggac 120
gtgacgaaca ttattcaggc cgacgaaccg acgaccctga ccactaatgc tctggatctg 180
aatagcgtgt tgggtaaaga ttacggtgcg ctgaaagata tcgtgatcaa cgcgaacccg 240
gcgagcccgc cgctgagcct gctggtcctg caccgtctgt tgtgcgagca tttccgcgtt 300
ctgtccaccg ttcataccca cagcagcgtg aagtctgttc cgtaatgact cgag       354

<210> 81
<211> 255
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      
      
      

<400> 81
acccctgacg cagatctgga cgtaacgaac atcattcaag cggatgaacc gacgaccctg 60
accactaatg ccctggatct gaactccgtc ctgggtaaag actacggcgc gttgaaggac 120
attgtgatca acgcaaatcc ggcgagcccg ccactgtctt tgctggtcct gcaccgtctg 180
ctgtgcgagc atttccgcgt tctgagcacc gtgcacacgc atagcagcgt taaaagcgtt 240
ccgtaatgac tcgag                                                  255

<210> 82
<211> 561
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      
      
      

<400> 82
aacctgagcc tgcaagcact ggagagccgc caagacgaca tcctgaaacg tctgtacgag 60
ttgaaagcag cagtcgacgg tctgagcaaa atgattcaga ctccggacgc ggatctggac 120
gttaccaaca ttattcaagc ggacgaaccg accacgctga ccaccaatgc gttggacctg 180
aacagcgttc tgggtaaaga ttacggcgcg ctgaaagata ttgtcatcaa cgctaacccg 240
gctagcccgc cgctgtccct gctggttctg caccgcttgc tgtgcgaaca cttccgtgtg 300
ctgtctaccg ttcacacgca tagcagcgtg aaaagcgtgc cggaaaacct gttgaagtgt 360
ttcggcgagc aaaataagaa acagccgcgt caagattatc aactgggctt tacgctgatc 420
tggaagaatg tcccaaagac ccagatgaag ttcagcatcc agaccatgtg ccctatcgag 480
ggtgagggta atatcgcccg ctttctgttt tccctgttcg gtcagaagca taatgccgtg 540
aacgcgacgt aatgactcga g                                           561

<210> 83
<211> 462
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      
      
      

<400> 83
acccctgacg cagatctgga cgtaacgaac atcattcaag cggatgagcc gaccacgctg 60
accacgaatg cgctggactt gaatagcgtt ctgggtaaag actacggtgc cctgaaagac 120
atcgtcatca acgcgaaccc agcgagcccg ccgttgtccc tgctggttct gcaccgcctg 180
ctgtgcgagc attttcgtgt gttgtcgact gtccacaccc acagctctgt gaaaagcgtg 240
ccggaaaacc tgctgaagtg cttcggcgaa caaaacaaga agcagccgcg tcaggattat 300
cagctgggtt tcacgctgat ttggaagaat gtccctaaaa cccaaatgaa attttctatt 360
cagaccatgt gtccgattga gggcgaaggt aacatcgcac gtttcctgtt tagcctgttc 420
ggccaaaagc ataatgctgt taatgcaacc taatgactcg ag                    462

<210> 84
<211> 330
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      
      
      

<400> 84
gccaaccctg cgagcccacc actgagcctg ttggtactgc accgcctgtt gtgcgagcat 60
ttccgtgttc tgagcaccgt gcacacgcac agcagcgtca agtctgtgcc ggaaaacttg 120
ctgaaatgct tcggtgaaca aaataagaaa caacctcgtc aagactacca gctgggcttc 180
accctgatct ggaagaacgt cccgaaaacg cagatgaaat ttagcatcca gaccatgtgt 240
ccgattgagg gcgagggtaa tattgcgcgt tttctgtttt cgctgttcgg tcagaagcat 300
aacgcagtta atgctactta atgactcgag                                  330

<210> 85
<211> 240
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized P38 from the multi-tRNA synthetase
      complex polynucleotide
      
      
      
      
      

<400> 85
tcgtccgtca aatccgtccc tgagaacctg ctgaaatgct tcggcgaaca gaacaagaaa 60
caaccgcgtc aggactacca gttgggtttc acgctgattt ggaagaacgt gccgaaaacg 120
caaatgaaat ttagcatcca aaccatgtgc cctatcgagg gtgagggtaa tattgcccgc 180
tttctgttca gcctgttcgg ccagaagcac aacgcagtta atgcgaccta atgactcgag 240

