
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited		
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN
  FRAGMENTS OF GLUTAMYL-PROLYL-tRNA SYNTHETASES
  

<130> 120161.444PC

<140> PCT                 
<141> 2011-05-04  

<150> US 61/331,280       
<151> 2010-05-04  

<150> US 61/331,265       
<151> 2010-05-04  

<150> US 61/331,084       
<151> 2010-05-04  

<160> 444

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 901
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val
            740                 745                 750         
Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys
        755                 760                 765             
Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu
    770                 775                 780                 
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys
785                 790                 795                 800 
Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser
                805                 810                 815     
Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala
            820                 825                 830         
Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala
        835                 840                 845             
Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr
    850                 855                 860                 
Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser
865                 870                 875                 880 
Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu
                885                 890                 895     
Glu Thr Pro Glu Ala
            900     


<210> 13
<211> 2703
<212> DNA
<213> Homo sapiens

<400> 13
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggattcc ttggtccttt acaatagagt ggctgttcaa 2280
ggagatgtgg ttcgtgaatt aaaagccaag aaagcaccaa aggaagatgt agatgcagct 2340
gtaaaacagc ttttgtcttt gaaagctgaa tataaggaga aaactggcca ggaatataaa 2400
cctggaaacc ctcctgctga aataggacag aatatttctt ctaattcctc agcaagtatt 2460
ctggaaagta aatctctgta tgatgaagtt gctgcacaag gggaggtggt tcgtaagcta 2520
aaagctgaaa aatcccctaa ggctaaaata aatgaagctg tagaatgctt actgtccctg 2580
aaggctcagt ataaagaaaa aactgggaag gagtacatac ctggtcagcc cccattatct 2640
caaagttcgg attcaagccc aaccagaaat tctgaacctg ctggtttaga aacaccagaa 2700
gcg                                                               2703

<210> 14
<211> 749
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp
            740                 745                 


<210> 15
<211> 2247
<212> DNA
<213> Homo sapiens

<400> 15
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggat                                     2247

<210> 16
<211> 1021
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val
            740                 745                 750         
Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys
        755                 760                 765             
Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu
    770                 775                 780                 
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys
785                 790                 795                 800 
Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser
                805                 810                 815     
Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala
            820                 825                 830         
Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala
        835                 840                 845             
Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr
    850                 855                 860                 
Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser
865                 870                 875                 880 
Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu
                885                 890                 895     
Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly
            900                 905                 910         
Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val
        915                 920                 925             
Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser
    930                 935                 940                 
Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp
945                 950                 955                 960 
Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn
                965                 970                 975     
Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn
            980                 985                 990         
Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro
        995                 1000                1005            
Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu
    1010                1015                1020    


<210> 17
<211> 3063
<212> DNA
<213> Homo sapiens

<400> 17
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggattcc ttggtccttt acaatagagt ggctgttcaa 2280
ggagatgtgg ttcgtgaatt aaaagccaag aaagcaccaa aggaagatgt agatgcagct 2340
gtaaaacagc ttttgtcttt gaaagctgaa tataaggaga aaactggcca ggaatataaa 2400
cctggaaacc ctcctgctga aataggacag aatatttctt ctaattcctc agcaagtatt 2460
ctggaaagta aatctctgta tgatgaagtt gctgcacaag gggaggtggt tcgtaagcta 2520
aaagctgaaa aatcccctaa ggctaaaata aatgaagctg tagaatgctt actgtccctg 2580
aaggctcagt ataaagaaaa aactgggaag gagtacatac ctggtcagcc cccattatct 2640
caaagttcgg attcaagccc aaccagaaat tctgaacctg ctggtttaga aacaccagaa 2700
gcgaaagtac tttttgacaa agtagcttct caaggggaag tagttcggaa acttaaaact 2760
gaaaaagccc ctaaggatca agtagatata gctgttcaag aactccttca gctaaaggca 2820
cagtacaagt ctttgatagg agtagagtat aagcctgtgt cggccactgg agctgaggac 2880
aaagataaga agaagaaaga aaaagaaaat aaatctgaaa agcagaataa gcctcagaaa 2940
caaaatgatg gccaaaggaa agacccttct aaaaaccaag gaggtgggct ctcatcaagt 3000
ggagcaggag aagggcaggg gcctaagaaa cagaccaggt tgggtcttga ggcaaaaaaa 3060
gaa                                                               3063

<210> 18
<211> 235
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg
225                 230                 235 


<210> 19
<211> 705
<212> DNA
<213> Homo sapiens

<400> 19
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgaga                 705

<210> 20
<211> 17
<212> PRT
<213> Mus musculus

<400> 20
Asn Ala Gly Asn Pro Pro Leu Glu Ala Leu Leu Ala Val Glu His Val
 1               5                  10                  15      
Lys
    


<210> 21
<211> 31
<212> PRT
<213> Mus musculus

<400> 21
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
            20                  25                  30      


<210> 22
<211> 4
<212> PRT
<213> Mus musculus

<400> 22
Tyr Leu Ala Arg
 1              


<210> 23
<211> 28
<212> PRT
<213> Mus musculus

<400> 23
Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu Met Glu His Thr
 1               5                  10                  15      
Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
            20                  25              


<210> 24
<211> 21
<212> PRT
<213> Mus musculus

<400> 24
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
 1               5                  10                  15      
Cys Leu Ser Leu Arg
            20      


<210> 25
<211> 20
<212> PRT
<213> Mus musculus

<400> 25
Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp Leu Cys Val Trp
 1               5                  10                  15      
Ala Thr Leu Lys
            20  


<210> 26
<211> 20
<212> PRT
<213> Mus musculus

<400> 26
Gly Ser Ala Ala Trp Gln Glu His Leu Lys Gln Asn Lys Thr Leu Val
 1               5                  10                  15      
His Val Lys Arg
            20  


<210> 27
<211> 12
<212> PRT
<213> Mus musculus

<400> 27
Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe Arg
 1               5                  10          


<210> 28
<211> 40
<212> PRT
<213> Mus musculus

<400> 28
Ser Val Gly Thr Lys Trp Asp Val Ser Gly Asn Arg Ala Thr Val Ala
 1               5                  10                  15      
Pro Asp Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly Ala
            20                  25                  30          
Glu Met Gly Lys Val Thr Val Arg
        35                  40  


<210> 29
<211> 15
<212> PRT
<213> Mus musculus

<400> 29
Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys
 1               5                  10                  15  


<210> 30
<211> 13
<212> PRT
<213> Mus musculus

<400> 30
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys
 1               5                  10              


<210> 31
<211> 6
<212> PRT
<213> Mus musculus

<400> 31
Gly Lys Leu Ile Met Arg
 1               5      


<210> 32
<211> 15
<212> PRT
<213> Mus musculus

<400> 32
Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys
 1               5                  10                  15  


<210> 33
<211> 28
<212> PRT
<213> Mus musculus

<400> 33
Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln Phe
 1               5                  10                  15      
Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys
            20                  25              


<210> 34
<211> 10
<212> PRT
<213> Mus musculus

<400> 34
Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
 1               5                  10  


<210> 35
<211> 12
<212> PRT
<213> Mus musculus

<400> 35
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys
 1               5                  10          


<210> 36
<211> 27
<212> PRT
<213> Mus musculus

<400> 36
Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys Asn Ser Val
 1               5                  10                  15      
Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys
            20                  25          


<210> 37
<211> 12
<212> PRT
<213> Mus musculus

<400> 37
Lys Gly Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg
 1               5                  10          


<210> 38
<211> 27
<212> PRT
<213> Mus musculus

<400> 38
Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg Asp Pro Thr
 1               5                  10                  15      
Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg
            20                  25          


<210> 39
<211> 50
<212> PRT
<213> Mus musculus

<400> 39
Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro
 1               5                  10                  15      
Ile Val Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu
            20                  25                  30          
Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly
        35                  40                  45              
Ile Arg
    50  


<210> 40
<211> 9
<212> PRT
<213> Mus musculus

<400> 40
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
 1               5                  


<210> 41
<211> 10
<212> PRT
<213> Mus musculus

<400> 41
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys
 1               5                  10  


<210> 42
<211> 22
<212> PRT
<213> Mus musculus

<400> 42
Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro
 1               5                  10                  15      
Arg Phe Pro Thr Val Arg
            20          


<210> 43
<211> 13
<212> PRT
<213> Mus musculus

<400> 43
Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys
 1               5                  10              


<210> 44
<211> 10
<212> PRT
<213> Mus musculus

<400> 44
Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg
 1               5                  10  


<210> 45
<211> 3
<212> PRT
<213> Mus musculus

<400> 45
His Pro Lys
 1          


<210> 46
<211> 14
<212> PRT
<213> Mus musculus

<400> 46
Asn Pro Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys
 1               5                  10                  


<210> 47
<211> 116
<212> PRT
<213> Mus musculus

<400> 47
Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met
 1               5                  10                  15      
Val Thr Phe Ile Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys
            20                  25                  30          
Asn Ala Asp Gly Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu
        35                  40                  45              
Asn Lys Asp Tyr Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser
    50                  55                  60                  
Thr His Ala Leu Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu
65                  70                  75                  80  
Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile
                85                  90                  95      
Asn Lys Asp Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu
            100                 105                 110         
Lys Asp Leu Lys
        115     


<210> 48
<211> 9
<212> PRT
<213> Mus musculus

<400> 48
Lys Gly Asp Ile Ile Gln Leu Gln Arg
 1               5                  


<210> 49
<211> 18
<212> PRT
<213> Mus musculus

<400> 49
Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser
 1               5                  10                  15      
Cys Arg
        


<210> 50
<211> 40
<212> PRT
<213> Mus musculus

<400> 50
Glu Ala Pro Cys Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu
 1               5                  10                  15      
Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ile Ser Lys
            20                  25                  30          
Lys Glu Thr Ser Ser Ala Pro Lys
        35                  40  


<210> 51
<211> 23
<212> PRT
<213> Mus musculus

<400> 51
Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala Thr Ala Glu Asp
 1               5                  10                  15      
Ser Ser Val Leu Tyr Ser Arg
            20              


<210> 52
<211> 9
<212> PRT
<213> Mus musculus

<400> 52
Val Ala Val Gln Gly Asp Val Val Arg
 1               5                  


<210> 53
<211> 5
<212> PRT
<213> Mus musculus

<400> 53
Glu Leu Lys Ala Lys
 1               5  


<210> 54
<211> 12
<212> PRT
<213> Mus musculus

<400> 54
Lys Ala Pro Lys Glu Asp Ile Asp Ala Ala Val Lys
 1               5                  10          


<210> 55
<211> 10
<212> PRT
<213> Mus musculus

<400> 55
Gln Leu Leu Thr Leu Lys Ala Glu Tyr Lys
 1               5                  10  


<210> 56
<211> 23
<212> PRT
<213> Mus musculus

<400> 56
Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala
 1               5                  10                  15      
Val Gln Thr Val Ser Thr Lys
            20              


<210> 57
<211> 16
<212> PRT
<213> Mus musculus

<400> 57
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      


<210> 58
<211> 15
<212> PRT
<213> Mus musculus

<400> 58
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
 1               5                  10                  15  


<210> 59
<211> 9
<212> PRT
<213> Mus musculus

<400> 59
Tyr Leu Ala Arg Ile Ala Thr Thr Ser
 1               5                  


<210> 60
<211> 23
<212> PRT
<213> Mus musculus

<400> 60
Gly Leu Tyr Gly Thr Asn Leu Met Glu His Thr Glu Ile Asp His Trp
 1               5                  10                  15      
Leu Glu Phe Ser Ala Thr Lys
            20              


<210> 61
<211> 61
<212> PRT
<213> Mus musculus

<400> 61
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
 1               5                  10                  15      
Cys Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala
            20                  25                  30          
Asp Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu
        35                  40                  45              
His Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg
    50                  55                  60      


<210> 62
<211> 12
<212> PRT
<213> Mus musculus

<400> 62
Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe Arg
 1               5                  10          


<210> 63
<211> 55
<212> PRT
<213> Mus musculus

<400> 63
Ser Val Gly Thr Lys Trp Asp Val Ser Gly Asn Arg Ala Thr Val Ala
 1               5                  10                  15      
Pro Asp Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly Ala
            20                  25                  30          
Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly Tyr
        35                  40                  45              
Leu His Ile Gly His Ala Lys
    50                  55  


<210> 64
<211> 13
<212> PRT
<213> Mus musculus

<400> 64
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys
 1               5                  10              


<210> 65
<211> 6
<212> PRT
<213> Mus musculus

<400> 65
Gly Lys Leu Ile Met Arg
 1               5      


<210> 66
<211> 15
<212> PRT
<213> Mus musculus

<400> 66
Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys
 1               5                  10                  15  


<210> 67
<211> 38
<212> PRT
<213> Mus musculus

<400> 67
Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln Phe
 1               5                  10                  15      
Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys
            20                  25                  30          
Leu Ile Gln Glu Gly Lys
        35              


<210> 68
<211> 12
<212> PRT
<213> Mus musculus

<400> 68
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys
 1               5                  10          


<210> 69
<211> 28
<212> PRT
<213> Mus musculus

<400> 69
Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys Asn Ser Val
 1               5                  10                  15      
Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys
            20                  25              


<210> 70
<211> 11
<212> PRT
<213> Mus musculus

<400> 70
Gly Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg
 1               5                  10      


<210> 71
<211> 31
<212> PRT
<213> Mus musculus

<400> 71
Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg Asp Pro Thr
 1               5                  10                  15      
Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly Asn Lys
            20                  25                  30      


<210> 72
<211> 55
<212> PRT
<213> Mus musculus

<400> 72
Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser
 1               5                  10                  15      
Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His Asp Arg
            20                  25                  30          
Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg Lys Pro
        35                  40                  45              
Tyr Ile Trp Glu Tyr Ser Arg
    50                  55  


<210> 73
<211> 12
<212> PRT
<213> Mus musculus

<400> 73
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys
 1               5                  10          


<210> 74
<211> 17
<212> PRT
<213> Mus musculus

<400> 74
Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro
 1               5                  10                  15      
Arg
    


<210> 75
<211> 81
<212> PRT
<213> Mus musculus

<400> 75
Phe Pro Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly
 1               5                  10                  15      
Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn
            20                  25                  30          
Met Glu Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro
        35                  40                  45              
Val Ala Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Val Pro Val
    50                  55                  60                  
Asn Val Leu Asp Ala Gln Glu Glu Met Lys Glu Val Ala Arg His Pro
65                  70                  75                  80  
Lys
    


<210> 76
<211> 14
<212> PRT
<213> Mus musculus

<400> 76
Asn Pro Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys
 1               5                  10                  


<210> 77
<211> 126
<212> PRT
<213> Mus musculus

<400> 77
Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met
 1               5                  10                  15      
Val Thr Phe Ile Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys
            20                  25                  30          
Asn Ala Asp Gly Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu
        35                  40                  45              
Asn Lys Asp Tyr Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser
    50                  55                  60                  
Thr His Ala Leu Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu
65                  70                  75                  80  
Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile
                85                  90                  95      
Asn Lys Asp Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu
            100                 105                 110         
Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg
        115                 120                 125     


<210> 78
<211> 18
<212> PRT
<213> Mus musculus

<400> 78
Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser
 1               5                  10                  15      
Cys Arg
        


<210> 79
<211> 15
<212> PRT
<213> Mus musculus

<400> 79
Glu Ala Pro Cys Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys
 1               5                  10                  15  


<210> 80
<211> 25
<212> PRT
<213> Mus musculus

<400> 80
Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ile Ser
 1               5                  10                  15      
Lys Lys Glu Thr Ser Ser Ala Pro Lys
            20                  25  


<210> 81
<211> 23
<212> PRT
<213> Mus musculus

<400> 81
Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala Thr Ala Glu Asp
 1               5                  10                  15      
Ser Ser Val Leu Tyr Ser Arg
            20              


<210> 82
<211> 38
<212> PRT
<213> Mus musculus

<400> 82
Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala
 1               5                  10                  15      
Pro Lys Glu Asp Ile Asp Ala Ala Val Lys Gln Leu Leu Thr Leu Lys
            20                  25                  30          
Ala Glu Tyr Lys Glu Lys
        35              


<210> 83
<211> 21
<212> PRT
<213> Mus musculus

<400> 83
Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val Gln
 1               5                  10                  15      
Thr Val Ser Thr Lys
            20      


<210> 84
<211> 14
<212> PRT
<213> Mus musculus

<400> 84
Ser Ser Ser Asn Thr Val Glu Ser Thr Ser Leu Tyr Asn Lys
 1               5                  10                  


<210> 85
<211> 20
<212> PRT
<213> Mus musculus

<400> 85
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala
 1               5                  10                  15      
Pro Lys Ala Lys
            20  


<210> 86
<211> 12
<212> PRT
<213> Mus musculus

<400> 86
Val Thr Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
 1               5                  10          


<210> 87
<211> 874
<212> PRT
<213> Mus musculus

<400> 87
Asn Ala Gly Asn Pro Pro Leu Glu Ala Leu Leu Ala Val Glu His Val
 1               5                  10                  15      
Lys Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu
            20                  25                  30          
Arg Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
        35                  40                  45              
Tyr Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu
    50                  55                  60                  
Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
65                  70                  75                  80  
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
                85                  90                  95      
Cys Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala
            100                 105                 110         
Asp Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu
        115                 120                 125             
His Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly
    130                 135                 140                 
Phe Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp
145                 150                 155                 160 
Val Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val
                165                 170                 175     
Gly Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val
            180                 185                 190         
Arg Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys
        195                 200                 205             
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu
    210                 215                 220                 
Ile Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe
225                 230                 235                 240 
Glu Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp
                245                 250                 255     
Gln Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala
            260                 265                 270         
Glu Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala
        275                 280                 285             
Glu Gln Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg
    290                 295                 300                 
Lys Asn Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys
305                 310                 315                 320 
Gly Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met
                325                 330                 335     
Ser Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys
            340                 345                 350         
Ile Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr
        355                 360                 365             
Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His
    370                 375                 380                 
Ala Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp
385                 390                 395                 400 
Ile Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser
                405                 410                 415     
Arg Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp
            420                 425                 430         
Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro
        435                 440                 445             
Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys
    450                 455                 460                 
Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu
465                 470                 475                 480 
Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala
                485                 490                 495     
Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Val Pro Val Asn Val
            500                 505                 510         
Leu Asp Ala Gln Glu Glu Met Lys Glu Val Ala Arg His Pro Lys Asn
        515                 520                 525             
Pro Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys Val Phe Ile
    530                 535                 540                 
Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met Val Thr Phe
545                 550                 555                 560 
Ile Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys Asn Ala Asp
                565                 570                 575     
Gly Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu Asn Lys Asp
            580                 585                 590         
Tyr Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser Thr His Ala
        595                 600                 605             
Leu Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu Ile Thr Lys
    610                 615                 620                 
Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile Asn Lys Asp
625                 630                 635                 640 
Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys Asp Leu
                645                 650                 655     
Lys Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg Gly Phe Phe Ile Cys
            660                 665                 670         
Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Arg Glu Ala Pro
        675                 680                 685             
Cys Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr
    690                 695                 700                 
Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ile Ser Lys Lys Glu Thr
705                 710                 715                 720 
Ser Ser Ala Pro Lys Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys
                725                 730                 735     
Ala Thr Ala Glu Asp Ser Ser Val Leu Tyr Ser Arg Val Ala Val Gln
            740                 745                 750         
Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp
        755                 760                 765             
Ile Asp Ala Ala Val Lys Gln Leu Leu Thr Leu Lys Ala Glu Tyr Lys
    770                 775                 780                 
Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala
785                 790                 795                 800 
Val Gln Thr Val Ser Thr Lys Ser Ser Ser Asn Thr Val Glu Ser Thr
                805                 810                 815     
Ser Leu Tyr Asn Lys Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu
            820                 825                 830         
Lys Ala Glu Lys Ala Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys
        835                 840                 845             
Leu Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Lys Asp Tyr
    850                 855                 860                 
Val Pro Gly Gln Pro Pro Ala Ser Gln Asn
865                 870                 


<210> 88
<211> 836
<212> PRT
<213> Mus musculus

<400> 88
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr
            20                  25                  30          
Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu Met
        35                  40                  45              
Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu
    50                  55                  60                  
Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His Cys
65                  70                  75                  80  
Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp
                85                  90                  95      
Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu His
            100                 105                 110         
Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly Phe
        115                 120                 125             
Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp Val
    130                 135                 140                 
Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val Gly
145                 150                 155                 160 
Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg
                165                 170                 175     
Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys Ala
            180                 185                 190         
Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu Ile
        195                 200                 205             
Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu
    210                 215                 220                 
Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln
225                 230                 235                 240 
Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu
                245                 250                 255     
Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala Glu
            260                 265                 270         
Gln Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys
        275                 280                 285             
Asn Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys Gly
    290                 295                 300                 
Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met Ser
305                 310                 315                 320 
Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys Ile
                325                 330                 335     
Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr Tyr
            340                 345                 350         
Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His Ala
        355                 360                 365             
Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile
    370                 375                 380                 
Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
385                 390                 395                 400 
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp Phe
                405                 410                 415     
Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro Thr
            420                 425                 430         
Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys Gln
        435                 440                 445             
Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu Trp
    450                 455                 460                 
Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala Pro
465                 470                 475                 480 
Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Val Pro Val Asn Val Leu
                485                 490                 495     
Asp Ala Gln Glu Glu Met Lys Glu Val Ala Arg His Pro Lys Asn Pro
            500                 505                 510         
Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys Val Phe Ile Glu
        515                 520                 525             
Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met Val Thr Phe Ile
    530                 535                 540                 
Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys Asn Ala Asp Gly
545                 550                 555                 560 
Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu Asn Lys Asp Tyr
                565                 570                 575     
Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser Thr His Ala Leu
            580                 585                 590         
Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu Ile Thr Lys Pro
        595                 600                 605             
Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile Asn Lys Asp Ser
    610                 615                 620                 
Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys Asp Leu Lys
625                 630                 635                 640 
Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg Gly Phe Phe Ile Cys Asp
                645                 650                 655     
Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Arg Glu Ala Pro Cys
            660                 665                 670         
Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr Ser
        675                 680                 685             
Gly Ser Lys Glu Lys Thr Lys Val Glu Ile Ser Lys Lys Glu Thr Ser
    690                 695                 700                 
Ser Ala Pro Lys Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala
705                 710                 715                 720 
Thr Ala Glu Asp Ser Ser Val Leu Tyr Ser Arg Val Ala Val Gln Gly
                725                 730                 735     
Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Ile
            740                 745                 750         
Asp Ala Ala Val Lys Gln Leu Leu Thr Leu Lys Ala Glu Tyr Lys Glu
        755                 760                 765             
Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val
    770                 775                 780                 
Gln Thr Val Ser Thr Lys Ser Ser Ser Asn Thr Val Glu Ser Thr Ser
785                 790                 795                 800 
Leu Tyr Asn Lys Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys
                805                 810                 815     
Ala Glu Lys Ala Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys Leu
            820                 825                 830         
Leu Ser Leu Lys
        835     


<210> 89
<211> 31
<212> PRT
<213> Mus musculus

<400> 89
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
            20                  25                  30      


<210> 90
<211> 93
<212> PRT
<213> Mus musculus

<400> 90
Tyr Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu
 1               5                  10                  15      
Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
            20                  25                  30          
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
        35                  40                  45              
Cys Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala
    50                  55                  60                  
Asp Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu
65                  70                  75                  80  
His Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg
                85                  90              


<210> 91
<211> 12
<212> PRT
<213> Mus musculus

<400> 91
Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe Arg
 1               5                  10          


<210> 92
<211> 74
<212> PRT
<213> Mus musculus

<400> 92
Ser Val Gly Thr Lys Trp Asp Val Ser Gly Asn Arg Ala Thr Val Ala
 1               5                  10                  15      
Pro Asp Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly Ala
            20                  25                  30          
Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly Tyr
        35                  40                  45              
Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr Gln
    50                  55                  60                  
Val Asn Phe Lys Gly Lys Leu Ile Met Arg
65                  70                  


<210> 93
<211> 15
<212> PRT
<213> Mus musculus

<400> 93
Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys
 1               5                  10                  15  


<210> 94
<211> 38
<212> PRT
<213> Mus musculus

<400> 94
Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln Phe
 1               5                  10                  15      
Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys
            20                  25                  30          
Leu Ile Gln Glu Gly Lys
        35              


<210> 95
<211> 12
<212> PRT
<213> Mus musculus

<400> 95
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys
 1               5                  10          


<210> 96
<211> 70
<212> PRT
<213> Mus musculus

<400> 96
Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys Asn Ser Val
 1               5                  10                  15      
Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe
            20                  25                  30          
Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn
        35                  40                  45              
Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His
    50                  55                  60                  
Pro Arg Thr Gly Asn Lys
65                  70  


<210> 97
<211> 25
<212> PRT
<213> Mus musculus

<400> 97
Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser
 1               5                  10                  15      
Ile Glu Gly Val Thr His Ala Leu Arg
            20                  25  


<210> 98
<211> 30
<212> PRT
<213> Mus musculus

<400> 98
Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu
 1               5                  10                  15      
Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
            20                  25                  30  


<210> 99
<211> 10
<212> PRT
<213> Mus musculus

<400> 99
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys
 1               5                  10  


<210> 100
<211> 100
<212> PRT
<213> Mus musculus

<400> 100
Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp
 1               5                  10                  15      
Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr
            20                  25                  30          
Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser
        35                  40                  45              
Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val
    50                  55                  60                  
Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val
65                  70                  75                  80  
Val Pro Val Asn Val Leu Asp Ala Gln Glu Glu Met Lys Glu Val Ala
                85                  90                  95      
Arg His Pro Lys
            100 


<210> 101
<211> 100
<212> PRT
<213> Mus musculus

<400> 101
Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp
 1               5                  10                  15      
Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr
            20                  25                  30          
Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser
        35                  40                  45              
Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val
    50                  55                  60                  
Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val
65                  70                  75                  80  
Val Pro Val Asn Val Leu Asp Ala Gln Glu Glu Met Lys Glu Val Ala
                85                  90                  95      
Arg His Pro Lys
            100 


<210> 102
<211> 14
<212> PRT
<213> Mus musculus

<400> 102
Asn Pro Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys
 1               5                  10                  


<210> 103
<211> 15
<212> PRT
<213> Mus musculus

<400> 103
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
 1               5                  10                  15  


<210> 104
<211> 53
<212> PRT
<213> Mus musculus

<400> 104
Tyr Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu
 1               5                  10                  15      
Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
            20                  25                  30          
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
        35                  40                  45              
Cys Leu Ser Leu Arg
    50              


<210> 105
<211> 20
<212> PRT
<213> Mus musculus

<400> 105
Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp Leu Cys Val Trp
 1               5                  10                  15      
Ala Thr Leu Lys
            20  


<210> 106
<211> 20
<212> PRT
<213> Mus musculus

<400> 106
Gly Ser Ala Ala Trp Gln Glu His Leu Lys Gln Asn Lys Thr Leu Val
 1               5                  10                  15      
His Val Lys Arg
            20  


<210> 107
<211> 12
<212> PRT
<213> Mus musculus

<400> 107
Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe Arg
 1               5                  10          


<210> 108
<211> 55
<212> PRT
<213> Mus musculus

<400> 108
Ser Val Gly Thr Lys Trp Asp Val Ser Gly Asn Arg Ala Thr Val Ala
 1               5                  10                  15      
Pro Asp Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly Ala
            20                  25                  30          
Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly Tyr
        35                  40                  45              
Leu His Ile Gly His Ala Lys
    50                  55  


<210> 109
<211> 13
<212> PRT
<213> Mus musculus

<400> 109
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys
 1               5                  10              


<210> 110
<211> 6
<212> PRT
<213> Mus musculus

<400> 110
Gly Lys Leu Ile Met Arg
 1               5      


<210> 111
<211> 15
<212> PRT
<213> Mus musculus

<400> 111
Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys
 1               5                  10                  15  


<210> 112
<211> 78
<212> PRT
<213> Mus musculus

<400> 112
Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln Phe
 1               5                  10                  15      
Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys
            20                  25                  30          
Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln
        35                  40                  45              
Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys Asn
    50                  55                  60                  
Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys
65                  70                  75              


<210> 113
<211> 11
<212> PRT
<213> Mus musculus

<400> 113
Gly Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg
 1               5                  10      


<210> 114
<211> 56
<212> PRT
<213> Mus musculus

<400> 114
Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg Asp Pro Thr
 1               5                  10                  15      
Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly Asn Lys Tyr
            20                  25                  30          
Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser Ile
        35                  40                  45              
Glu Gly Val Thr His Ala Leu Arg
    50                  55      


<210> 115
<211> 21
<212> PRT
<213> Mus musculus

<400> 115
Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu
 1               5                  10                  15      
Ala Leu Gly Ile Arg
            20      


<210> 116
<211> 9
<212> PRT
<213> Mus musculus

<400> 116
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
 1               5                  


<210> 117
<211> 10
<212> PRT
<213> Mus musculus

<400> 117
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys
 1               5                  10  


<210> 118
<211> 100
<212> PRT
<213> Mus musculus

<400> 118
Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp
 1               5                  10                  15      
Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr
            20                  25                  30          
Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser
        35                  40                  45              
Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val
    50                  55                  60                  
Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val
65                  70                  75                  80  
Val Pro Val Asn Val Leu Asp Ala Gln Glu Glu Met Lys Glu Val Ala
                85                  90                  95      
Arg His Pro Lys
            100 


<210> 119
<211> 14
<212> PRT
<213> Mus musculus

<400> 119
Asn Pro Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys
 1               5                  10                  


<210> 120
<211> 126
<212> PRT
<213> Mus musculus

<400> 120
Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met
 1               5                  10                  15      
Val Thr Phe Ile Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys
            20                  25                  30          
Asn Ala Asp Gly Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu
        35                  40                  45              
Asn Lys Asp Tyr Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser
    50                  55                  60                  
Thr His Ala Leu Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu
65                  70                  75                  80  
Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile
                85                  90                  95      
Asn Lys Asp Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu
            100                 105                 110         
Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg
        115                 120                 125     


<210> 121
<211> 18
<212> PRT
<213> Mus musculus

<400> 121
Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser
 1               5                  10                  15      
Cys Arg
        


<210> 122
<211> 524
<212> PRT
<213> Mus musculus

<400> 122
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr
            20                  25                  30          
Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu Met
        35                  40                  45              
Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu
    50                  55                  60                  
Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His Cys
65                  70                  75                  80  
Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp
                85                  90                  95      
Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu His
            100                 105                 110         
Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly Phe
        115                 120                 125             
Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp Val
    130                 135                 140                 
Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val Gly
145                 150                 155                 160 
Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg
                165                 170                 175     
Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys Ala
            180                 185                 190         
Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu Ile
        195                 200                 205             
Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu
    210                 215                 220                 
Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln
225                 230                 235                 240 
Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu
                245                 250                 255     
Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala Glu
            260                 265                 270         
Gln Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys
        275                 280                 285             
Asn Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys Gly
    290                 295                 300                 
Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met Ser
305                 310                 315                 320 
Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys Ile
                325                 330                 335     
Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr Tyr
            340                 345                 350         
Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His Ala
        355                 360                 365             
Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile
    370                 375                 380                 
Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
385                 390                 395                 400 
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp Phe
                405                 410                 415     
Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro Thr
            420                 425                 430         
Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys Gln
        435                 440                 445             
Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu Trp
    450                 455                 460                 
Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala Pro
465                 470                 475                 480 
Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Val Pro Val Asn Val Leu
                485                 490                 495     
Asp Ala Gln Glu Glu Met Lys Glu Val Ala Arg His Pro Lys Asn Pro
            500                 505                 510         
Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys
        515                 520                 


<210> 123
<211> 667
<212> PRT
<213> Mus musculus

<400> 123
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr
 1               5                  10                  15      
Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu Met
            20                  25                  30          
Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu
        35                  40                  45              
Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His Cys
    50                  55                  60                  
Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp
65                  70                  75                  80  
Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu His
                85                  90                  95      
Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly Phe
            100                 105                 110         
Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp Val
        115                 120                 125             
Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val Gly
    130                 135                 140                 
Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg
145                 150                 155                 160 
Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys Ala
                165                 170                 175     
Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu Ile
            180                 185                 190         
Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu
        195                 200                 205             
Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln
    210                 215                 220                 
Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu
225                 230                 235                 240 
Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala Glu
                245                 250                 255     
Gln Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys
            260                 265                 270         
Asn Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys Gly
        275                 280                 285             
Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met Ser
    290                 295                 300                 
Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys Ile
305                 310                 315                 320 
Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr Tyr
                325                 330                 335     
Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His Ala
            340                 345                 350         
Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile
        355                 360                 365             
Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
    370                 375                 380                 
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp Phe
385                 390                 395                 400 
Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro Thr
                405                 410                 415     
Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys Gln
            420                 425                 430         
Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu Trp
        435                 440                 445             
Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala Pro
    450                 455                 460                 
Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Val Pro Val Asn Val Leu
465                 470                 475                 480 
Asp Ala Gln Glu Glu Met Lys Glu Val Ala Arg His Pro Lys Asn Pro
                485                 490                 495     
Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys Val Phe Ile Glu
            500                 505                 510         
Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met Val Thr Phe Ile
        515                 520                 525             
Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys Asn Ala Asp Gly
    530                 535                 540                 
Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu Asn Lys Asp Tyr
545                 550                 555                 560 
Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser Thr His Ala Leu
                565                 570                 575     
Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu Ile Thr Lys Pro
            580                 585                 590         
Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile Asn Lys Asp Ser
        595                 600                 605             
Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys Asp Leu Lys
    610                 615                 620                 
Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg Gly Phe Phe Ile Cys Asp
625                 630                 635                 640 
Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Arg Glu Ala Pro Cys
                645                 650                 655     
Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys
            660                 665         


<210> 124
<211> 31
<212> PRT
<213> Mus musculus

<400> 124
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
            20                  25                  30      


<210> 125
<211> 53
<212> PRT
<213> Mus musculus

<400> 125
Tyr Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu
 1               5                  10                  15      
Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
            20                  25                  30          
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
        35                  40                  45              
Cys Leu Ser Leu Arg
    50              


<210> 126
<211> 20
<212> PRT
<213> Mus musculus

<400> 126
Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp Leu Cys Val Trp
 1               5                  10                  15      
Ala Thr Leu Lys
            20  


<210> 127
<211> 20
<212> PRT
<213> Mus musculus

<400> 127
Gly Ser Ala Ala Trp Gln Glu His Leu Lys Gln Asn Lys Thr Leu Val
 1               5                  10                  15      
His Val Lys Arg
            20  


<210> 128
<211> 12
<212> PRT
<213> Mus musculus

<400> 128
Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe Arg
 1               5                  10          


<210> 129
<211> 55
<212> PRT
<213> Mus musculus

<400> 129
Ser Val Gly Thr Lys Trp Asp Val Ser Gly Asn Arg Ala Thr Val Ala
 1               5                  10                  15      
Pro Asp Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly Ala
            20                  25                  30          
Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly Tyr
        35                  40                  45              
Leu His Ile Gly His Ala Lys
    50                  55  


<210> 130
<211> 13
<212> PRT
<213> Mus musculus

<400> 130
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys
 1               5                  10              


<210> 131
<211> 6
<212> PRT
<213> Mus musculus

<400> 131
Gly Lys Leu Ile Met Arg
 1               5      


<210> 132
<211> 15
<212> PRT
<213> Mus musculus

<400> 132
Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys
 1               5                  10                  15  


<210> 133
<211> 120
<212> PRT
<213> Mus musculus

<400> 133
Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln Phe
 1               5                  10                  15      
Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys
            20                  25                  30          
Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln
        35                  40                  45              
Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys Asn
    50                  55                  60                  
Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys Gly Ser
65                  70                  75                  80  
Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met Ser Ser
                85                  90                  95      
Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln
            100                 105                 110         
Pro His Pro Arg Thr Gly Asn Lys
        115                 120 


<210> 134
<211> 25
<212> PRT
<213> Mus musculus

<400> 134
Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser
 1               5                  10                  15      
Ile Glu Gly Val Thr His Ala Leu Arg
            20                  25  


<210> 135
<211> 21
<212> PRT
<213> Mus musculus

<400> 135
Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu
 1               5                  10                  15      
Ala Leu Gly Ile Arg
            20      


<210> 136
<211> 119
<212> PRT
<213> Mus musculus

<400> 136
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
 1               5                  10                  15      
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
            20                  25                  30          
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
        35                  40                  45              
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
    50                  55                  60                  
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
65                  70                  75                  80  
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
                85                  90                  95      
Lys Glu Val Val Pro Val Asn Val Leu Asp Ala Gln Glu Glu Met Lys
            100                 105                 110         
Glu Val Ala Arg His Pro Lys
        115                 


<210> 137
<211> 14
<212> PRT
<213> Mus musculus

<400> 137
Asn Pro Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys
 1               5                  10                  


<210> 138
<211> 98
<212> PRT
<213> Mus musculus

<400> 138
Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met
 1               5                  10                  15      
Val Thr Phe Ile Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys
            20                  25                  30          
Asn Ala Asp Gly Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu
        35                  40                  45              
Asn Lys Asp Tyr Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser
    50                  55                  60                  
Thr His Ala Leu Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu
65                  70                  75                  80  
Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile
                85                  90                  95      
Asn Lys
        


<210> 139
<211> 15
<212> PRT
<213> Mus musculus

<400> 139
Asp Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys
 1               5                  10                  15  


<210> 140
<211> 3
<212> PRT
<213> Mus musculus

<400> 140
Asp Leu Lys
 1          


<210> 141
<211> 9
<212> PRT
<213> Mus musculus

<400> 141
Lys Gly Asp Ile Ile Gln Leu Gln Arg
 1               5                  


<210> 142
<211> 18
<212> PRT
<213> Mus musculus

<400> 142
Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser
 1               5                  10                  15      
Cys Arg
        


<210> 143
<211> 40
<212> PRT
<213> Mus musculus

<400> 143
Glu Ala Pro Cys Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu
 1               5                  10                  15      
Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ile Ser Lys
            20                  25                  30          
Lys Glu Thr Ser Ser Ala Pro Lys
        35                  40  


<210> 144
<211> 23
<212> PRT
<213> Mus musculus

<400> 144
Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala Thr Ala Glu Asp
 1               5                  10                  15      
Ser Ser Val Leu Tyr Ser Arg
            20              


<210> 145
<211> 9
<212> PRT
<213> Mus musculus

<400> 145
Val Ala Val Gln Gly Asp Val Val Arg
 1               5                  


<210> 146
<211> 29
<212> PRT
<213> Mus musculus

<400> 146
Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Ile Asp Ala Ala Val
 1               5                  10                  15      
Lys Gln Leu Leu Thr Leu Lys Ala Glu Tyr Lys Glu Lys
            20                  25                  


<210> 147
<211> 35
<212> PRT
<213> Mus musculus

<400> 147
Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val Gln
 1               5                  10                  15      
Thr Val Ser Thr Lys Ser Ser Ser Asn Thr Val Glu Ser Thr Ser Leu
            20                  25                  30          
Tyr Asn Lys
        35  


<210> 148
<211> 18
<212> PRT
<213> Mus musculus

<400> 148
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala
 1               5                  10                  15      
Pro Lys
        


<210> 149
<211> 14
<212> PRT
<213> Mus musculus

<400> 149
Ala Lys Val Thr Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
 1               5                  10                  


<210> 150
<211> 6
<212> PRT
<213> Mus musculus

<400> 150
Ala Glu Tyr Lys Glu Lys
 1               5      


<210> 151
<211> 15
<212> PRT
<213> Mus musculus

<400> 151
Thr Gly Lys Asp Tyr Val Pro Gly Gln Pro Pro Ala Ser Gln Asn
 1               5                  10                  15  


<210> 152
<211> 109
<212> PRT
<213> Mus musculus

<400> 152
Ser His Ser Asn Pro Val Ser Asn Ala Gln Pro Ala Gly Ala Glu Lys
 1               5                  10                  15      
Pro Glu Ala Lys Val Leu Phe Asp Arg Val Ala Cys Gln Gly Glu Val
            20                  25                  30          
Val Arg Lys Leu Lys Ala Glu Lys Ala Ser Lys Asp Gln Val Asp Ser
        35                  40                  45              
Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Thr
    50                  55                  60                  
Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp
65                  70                  75                  80  
Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro
                85                  90                  95      
Gln Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys
            100                 105                 


<210> 153
<211> 18
<212> PRT
<213> Mus musculus

<400> 153
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 154
<211> 984
<212> PRT
<213> Mus musculus

<400> 154
Gly Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Leu Leu Arg
 1               5                  10                  15      
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr
            20                  25                  30          
Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu Met
        35                  40                  45              
Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu
    50                  55                  60                  
Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His Cys
65                  70                  75                  80  
Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp
                85                  90                  95      
Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu His
            100                 105                 110         
Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly Phe
        115                 120                 125             
Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp Val
    130                 135                 140                 
Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val Gly
145                 150                 155                 160 
Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg
                165                 170                 175     
Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys Ala
            180                 185                 190         
Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu Ile
        195                 200                 205             
Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe Glu
    210                 215                 220                 
Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp Gln
225                 230                 235                 240 
Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala Glu
                245                 250                 255     
Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala Glu
            260                 265                 270         
Gln Met Lys Ala Glu Arg Glu Gln Arg Thr Glu Ser Lys His Arg Lys
        275                 280                 285             
Asn Ser Val Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys Gly
    290                 295                 300                 
Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met Ser
305                 310                 315                 320 
Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys Ile
                325                 330                 335     
Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr Tyr
            340                 345                 350         
Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His Ala
        355                 360                 365             
Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp Ile
    370                 375                 380                 
Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser Arg
385                 390                 395                 400 
Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp Phe
                405                 410                 415     
Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro Thr
            420                 425                 430         
Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys Gln
        435                 440                 445             
Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu Trp
    450                 455                 460                 
Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala Pro
465                 470                 475                 480 
Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Val Pro Val Asn Val Leu
                485                 490                 495     
Asp Ala Gln Glu Glu Met Lys Glu Val Ala Arg His Pro Lys Asn Pro
            500                 505                 510         
Asp Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys Val Phe Ile Glu
        515                 520                 525             
Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met Val Thr Phe Ile
    530                 535                 540                 
Asn Trp Gly Asn Ile Asn Ile Thr Lys Ile His Lys Asn Ala Asp Gly
545                 550                 555                 560 
Lys Ile Thr Ser Leu Asp Ala Lys Leu Asn Leu Glu Asn Lys Asp Tyr
                565                 570                 575     
Lys Lys Thr Thr Lys Ile Thr Trp Leu Ala Glu Ser Thr His Ala Leu
            580                 585                 590         
Ser Ile Pro Ala Val Cys Val Thr Tyr Glu His Leu Ile Thr Lys Pro
        595                 600                 605             
Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Ile Asn Lys Asp Ser
    610                 615                 620                 
Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys Asp Leu Lys
625                 630                 635                 640 
Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg Gly Phe Phe Ile Cys Asp
                645                 650                 655     
Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Arg Glu Ala Pro Cys
            660                 665                 670         
Ile Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr Ser
        675                 680                 685             
Gly Ser Lys Glu Lys Thr Lys Val Glu Ile Ser Lys Lys Glu Thr Ser
    690                 695                 700                 
Ser Ala Pro Lys Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala
705                 710                 715                 720 
Thr Ala Glu Asp Ser Ser Val Leu Tyr Ser Arg Val Ala Val Gln Gly
                725                 730                 735     
Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Ile
            740                 745                 750         
Asp Ala Ala Val Lys Gln Leu Leu Thr Leu Lys Ala Glu Tyr Lys Glu
        755                 760                 765             
Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val
    770                 775                 780                 
Gln Thr Val Ser Thr Lys Ser Ser Ser Asn Thr Val Glu Ser Thr Ser
785                 790                 795                 800 
Leu Tyr Asn Lys Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys
                805                 810                 815     
Ala Glu Lys Ala Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys Leu
            820                 825                 830         
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Lys Asp Tyr Val
        835                 840                 845             
Pro Gly Gln Pro Pro Ala Ser Gln Asn Ser His Ser Asn Pro Val Ser
    850                 855                 860                 
Asn Ala Gln Pro Ala Gly Ala Glu Lys Pro Glu Ala Lys Val Leu Phe
865                 870                 875                 880 
Asp Arg Val Ala Cys Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu
                885                 890                 895     
Lys Ala Ser Lys Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln
            900                 905                 910         
Leu Lys Ala Gln Tyr Lys Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val
        915                 920                 925             
Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu
    930                 935                 940                 
Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln
945                 950                 955                 960 
Gly Lys Asp Ser Ser Lys Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly
                965                 970                 975     
Ala Gly Glu Gly Gln Gly Pro Lys
            980                 


<210> 155
<211> 15
<212> PRT
<213> Mus musculus

<400> 155
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg
 1               5                  10                  15  


<210> 156
<211> 160
<212> PRT
<213> Mus musculus

<400> 156
Tyr Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu
 1               5                  10                  15      
Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
            20                  25                  30          
Leu Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His
        35                  40                  45              
Cys Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala
    50                  55                  60                  
Asp Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu
65                  70                  75                  80  
His Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly
                85                  90                  95      
Phe Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp
            100                 105                 110         
Val Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val
        115                 120                 125             
Gly Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val
    130                 135                 140                 
Arg Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys
145                 150                 155                 160 


<210> 157
<211> 13
<212> PRT
<213> Mus musculus

<400> 157
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys
 1               5                  10              


<210> 158
<211> 188
<212> PRT
<213> Mus musculus

<400> 158
Val Ser Glu Thr Val Ala Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr
 1               5                  10                  15      
Leu Ala Arg Ile Ala Thr Thr Ser Gly Leu Tyr Gly Thr Asn Leu Met
            20                  25                  30          
Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu
        35                  40                  45              
Ser Ser Cys Asp Arg Leu Thr Ser Ala Ile Asn Glu Leu Asn His Cys
    50                  55                  60                  
Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Thr Leu Ala Asp
65                  70                  75                  80  
Leu Cys Val Trp Ala Thr Leu Lys Gly Ser Ala Ala Trp Gln Glu His
                85                  90                  95      
Leu Lys Gln Asn Lys Thr Leu Val His Val Lys Arg Trp Phe Gly Phe
            100                 105                 110         
Leu Glu Ala Gln Gln Ala Phe Arg Ser Val Gly Thr Lys Trp Asp Val
        115                 120                 125             
Ser Gly Asn Arg Ala Thr Val Ala Pro Asp Lys Lys Gln Asp Val Gly
    130                 135                 140                 
Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg
145                 150                 155                 160 
Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys Ala
                165                 170                 175     
Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys
            180                 185             


<210> 159
<211> 233
<212> PRT
<213> Homo sapiens

<400> 159
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Leu Ser Trp Lys Met Leu Gln Cys Cys Ile Ser Asn Gln Ile Asn Leu
    210                 215                 220                 
Leu Ile Leu Arg Ile Ile Leu Lys Leu
225                 230             


<210> 160
<211> 702
<212> DNA
<213> Homo sapiens

<400> 160
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tgggttatct tggaagatgt tgcaatgttg catatcaaac 660
cagatcaatt tacttatact tcggatcatt ttgaaactat aa                    702

<210> 161
<211> 1488
<212> PRT
<213> Homo sapiens

<400> 161
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val
            740                 745                 750         
Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys
        755                 760                 765             
Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu
    770                 775                 780                 
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys
785                 790                 795                 800 
Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser
                805                 810                 815     
Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala
            820                 825                 830         
Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala
        835                 840                 845             
Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr
    850                 855                 860                 
Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser
865                 870                 875                 880 
Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu
                885                 890                 895     
Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly
            900                 905                 910         
Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val
        915                 920                 925             
Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser
    930                 935                 940                 
Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp
945                 950                 955                 960 
Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn
                965                 970                 975     
Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn
            980                 985                 990         
Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro
        995                 1000                1005            
Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu
    1010                1015                1020                
Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr
1025                1030                1035               1040 
His Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile
                1045                1050                1055    
Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly
            1060                1065                1070        
Val Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu
        1075                1080                1085            
Lys Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val
    1090                1095                1100                
Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro
1105                1110                1115               1120 
Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser
                1125                1130                1135    
His Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg
            1140                1145                1150        
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu
        1155                1160                1165            
Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu
    1170                1175                1180                
Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu
1185                1190                1195               1200 
Leu Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe
                1205                1210                1215    
Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser
            1220                1225                1230        
Gly Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe
        1235                1240                1245            
Ser Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu
    1250                1255                1260                
Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile
1265                1270                1275               1280 
Gly Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro
                1285                1290                1295    
Pro Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr
            1300                1305                1310        
Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn
        1315                1320                1325            
Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp
    1330                1335                1340                
Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu
1345                1350                1355               1360 
Lys Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser
                1365                1370                1375    
Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val
            1380                1385                1390        
Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile
        1395                1400                1405            
Gln Val Thr Leu Phe Thr Arg Leu Phe Arg Phe His Ser Val Gly Lys
    1410                1415                1420                
Leu Thr Val Arg Thr Gly Ser Lys Arg Pro Leu Pro Gly Ile Lys Ile
1425                1430                1435               1440 
Leu Asn Leu Val Leu His Pro Trp Glu Leu Lys Ala Phe Ala Ser Pro
                1445                1450                1455    
Ser Asn His Ser Val Asn Cys Ser Leu Glu Pro Asn Val Ser Val Ala
            1460                1465                1470        
Arg Thr Leu Pro Ser Thr Thr Pro Tyr Leu Val Ala Ala Thr Glu Gly
        1475                1480                1485            


<210> 162
<211> 4467
<212> DNA
<213> Homo sapiens

<400> 162
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggattcc ttggtccttt acaatagagt ggctgttcaa 2280
ggagatgtgg ttcgtgaatt aaaagccaag aaagcaccaa aggaagatgt agatgcagct 2340
gtaaaacagc ttttgtcttt gaaagctgaa tataaggaga aaactggcca ggaatataaa 2400
cctggaaacc ctcctgctga aataggacag aatatttctt ctaattcctc agcaagtatt 2460
ctggaaagta aatctctgta tgatgaagtt gctgcacaag gggaggtggt tcgtaagcta 2520
aaagctgaaa aatcccctaa ggctaaaata aatgaagctg tagaatgctt actgtccctg 2580
aaggctcagt ataaagaaaa aactgggaag gagtacatac ctggtcagcc cccattatct 2640
caaagttcgg attcaagccc aaccagaaat tctgaacctg ctggtttaga aacaccagaa 2700
gcgaaagtac tttttgacaa agtagcttct caaggggaag tagttcggaa acttaaaact 2760
gaaaaagccc ctaaggatca agtagatata gctgttcaag aactccttca gctaaaggca 2820
cagtacaagt ctttgatagg agtagagtat aagcctgtgt cggccactgg agctgaggac 2880
aaagataaga agaagaaaga aaaagaaaat aaatctgaaa agcagaataa gcctcagaaa 2940
caaaatgatg gccaaaggaa agacccttct aaaaaccaag gaggtgggct ctcatcaagt 3000
ggagcaggag aagggcaggg gcctaagaaa cagaccaggt tgggtcttga ggcaaaaaaa 3060
gaagaaaatc ttgctgattg gtattctcag gtcatcacaa agtcagaaat gattgaatac 3120
catgacataa gtggctgtta tattcttcgt ccctgggcct atgccatttg ggaagccatc 3180
aaggactttt ttgatgctga gatcaagaaa cttggtgttg aaaactgcta cttccccatg 3240
tttgtgtctc aaagtgcatt agagaaagag aagactcatg ttgctgactt tgccccagag 3300
gttgcttggg ttacaagatc tggcaaaacc gagctggcag aaccaattgc cattcgtcct 3360
actagtgaaa cagtaatgta tcctgcatat gcaaaatggg tacagtcaca cagagacctg 3420
cccatcaagc tcaatcagtg gtgcaatgtg gtgcgttggg aattcaagca tcctcagcct 3480
ttcctacgta ctcgtgaatt tctttggcag gaagggcaca gtgcttttgc taccatggaa 3540
gaggcagcgg aagaggtctt gcagatactt gacttatatg ctcaggtata tgaagaactc 3600
ctggcaattc ctgttgttaa aggaagaaag acggaaaagg aaaaatttgc aggaggagac 3660
tatacaacta caatagaagc atttatatct gctagtggaa gagctatcca gggaggaaca 3720
tcacatcatt tagggcagaa tttttccaaa atgtttgaaa tcgtttttga agatccaaag 3780
ataccaggag agaagcaatt tgcctatcaa aactcctggg gcctgacaac tcgaactatt 3840
ggtgttatga ccatggttca tggggacaac atgggtttag tattaccacc ccgtgtagca 3900
tgtgttcagg tggtgattat tccttgtggc attaccaatg cactttctga agaagacaaa 3960
gaagcgctga ttgcaaaatg caatgattat cgaaggcgat tactcagtgt taacatccgc 4020
gttagagctg atttacgaga taattattct ccaggttgga aattcaatca ctgggagctc 4080
aagggagttc ccattagact tgaagttggg ccacgtgata tgaagagctg tcagtttgta 4140
gccgtcagac gagatactgg agaaaagctg acagttgctg aaaatgaggc agagactaaa 4200
cttcaagcta ttttggaaga catccaggtc acccttttca caagattgtt cagattccat 4260
tctgtgggga aattgactgt gaggactgga tcaaaaagac cactgccagg gatcaagatc 4320
ttgaacctgg tgctccatcc atgggagcta aaagcctttg catccccttc aaaccactct 4380
gtgaactgca gcctggagcc aaatgtgtct gtggcaagaa ccctgccaag tactacacct 4440
tatttggtcg cagctactga gggatga                                     4467

<210> 163
<211> 929
<212> PRT
<213> Homo sapiens

<400> 163
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val
            740                 745                 750         
Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys
        755                 760                 765             
Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu
    770                 775                 780                 
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys
785                 790                 795                 800 
Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser
                805                 810                 815     
Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala
            820                 825                 830         
Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala
        835                 840                 845             
Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr
    850                 855                 860                 
Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser
865                 870                 875                 880 
Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu
                885                 890                 895     
Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly
            900                 905                 910         
Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Gly Ser Arg
        915                 920                 925             
Ser
    


<210> 164
<211> 2790
<212> DNA
<213> Homo sapiens

<400> 164
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggattcc ttggtccttt acaatagagt ggctgttcaa 2280
ggagatgtgg ttcgtgaatt aaaagccaag aaagcaccaa aggaagatgt agatgcagct 2340
gtaaaacagc ttttgtcttt gaaagctgaa tataaggaga aaactggcca ggaatataaa 2400
cctggaaacc ctcctgctga aataggacag aatatttctt ctaattcctc agcaagtatt 2460
ctggaaagta aatctctgta tgatgaagtt gctgcacaag gggaggtggt tcgtaagcta 2520
aaagctgaaa aatcccctaa ggctaaaata aatgaagctg tagaatgctt actgtccctg 2580
aaggctcagt ataaagaaaa aactgggaag gagtacatac ctggtcagcc cccattatct 2640
caaagttcgg attcaagccc aaccagaaat tctgaacctg ctggtttaga aacaccagaa 2700
gcgaaagtac tttttgacaa agtagcttct caaggggaag tagttcggaa acttaaaact 2760
gaaaaagccc ctaagggatc aagatcttga                                  2790

<210> 165
<211> 1460
<212> PRT
<213> Homo sapiens

<400> 165
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val
            740                 745                 750         
Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys
        755                 760                 765             
Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu
    770                 775                 780                 
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys
785                 790                 795                 800 
Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser
                805                 810                 815     
Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala
            820                 825                 830         
Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala
        835                 840                 845             
Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr
    850                 855                 860                 
Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser
865                 870                 875                 880 
Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu
                885                 890                 895     
Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly
            900                 905                 910         
Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val
        915                 920                 925             
Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser
    930                 935                 940                 
Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp
945                 950                 955                 960 
Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn
                965                 970                 975     
Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn
            980                 985                 990         
Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro
        995                 1000                1005            
Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu
    1010                1015                1020                
Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr
1025                1030                1035               1040 
His Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile
                1045                1050                1055    
Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly
            1060                1065                1070        
Val Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu
        1075                1080                1085            
Lys Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val
    1090                1095                1100                
Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro
1105                1110                1115               1120 
Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser
                1125                1130                1135    
His Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg
            1140                1145                1150        
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu
        1155                1160                1165            
Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu
    1170                1175                1180                
Glu Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe
1185                1190                1195               1200 
Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala
                1205                1210                1215    
Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr
            1220                1225                1230        
Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala
        1235                1240                1245            
Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser
    1250                1255                1260                
Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg
1265                1270                1275               1280 
Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn
                1285                1290                1295    
Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro
            1300                1305                1310        
Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val
        1315                1320                1325            
Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu
    1330                1335                1340                
Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu
1345                1350                1355               1360 
Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn
                1365                1370                1375    
Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln
            1380                1385                1390        
Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr
        1395                1400                1405            
Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala
    1410                1415                1420                
Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly
1425                1430                1435               1440 
Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe
                1445                1450                1455    
Gly Arg Ser Tyr
            1460


<210> 166
<211> 4383
<212> DNA
<213> Homo sapiens

<400> 166
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggattcc ttggtccttt acaatagagt ggctgttcaa 2280
ggagatgtgg ttcgtgaatt aaaagccaag aaagcaccaa aggaagatgt agatgcagct 2340
gtaaaacagc ttttgtcttt gaaagctgaa tataaggaga aaactggcca ggaatataaa 2400
cctggaaacc ctcctgctga aataggacag aatatttctt ctaattcctc agcaagtatt 2460
ctggaaagta aatctctgta tgatgaagtt gctgcacaag gggaggtggt tcgtaagcta 2520
aaagctgaaa aatcccctaa ggctaaaata aatgaagctg tagaatgctt actgtccctg 2580
aaggctcagt ataaagaaaa aactgggaag gagtacatac ctggtcagcc cccattatct 2640
caaagttcgg attcaagccc aaccagaaat tctgaacctg ctggtttaga aacaccagaa 2700
gcgaaagtac tttttgacaa agtagcttct caaggggaag tagttcggaa acttaaaact 2760
gaaaaagccc ctaaggatca agtagatata gctgttcaag aactccttca gctaaaggca 2820
cagtacaagt ctttgatagg agtagagtat aagcctgtgt cggccactgg agctgaggac 2880
aaagataaga agaagaaaga aaaagaaaat aaatctgaaa agcagaataa gcctcagaaa 2940
caaaatgatg gccaaaggaa agacccttct aaaaaccaag gaggtgggct ctcatcaagt 3000
ggagcaggag aagggcaggg gcctaagaaa cagaccaggt tgggtcttga ggcaaaaaaa 3060
gaagaaaatc ttgctgattg gtattctcag gtcatcacaa agtcagaaat gattgaatac 3120
catgacataa gtggctgtta tattcttcgt ccctgggcct atgccatttg ggaagccatc 3180
aaggactttt ttgatgctga gatcaagaaa cttggtgttg aaaactgcta cttccccatg 3240
tttgtgtctc aaagtgcatt agagaaagag aagactcatg ttgctgactt tgccccagag 3300
gttgcttggg ttacaagatc tggcaaaacc gagctggcag aaccaattgc cattcgtcct 3360
actagtgaaa cagtaatgta tcctgcatat gcaaaatggg tacagtcaca cagagacctg 3420
cccatcaagc tcaatcagtg gtgcaatgtg gtgcgttggg aattcaagca tcctcagcct 3480
ttcctacgta ctcgtgaatt tctttggcag gaagggcaca gtgcttttgc taccatggaa 3540
gaggcagcgg aagagggagg aacatcacat catttagggc agaatttttc caaaatgttt 3600
gaaatcgttt ttgaagatcc aaagatacca ggagagaagc aatttgccta tcaaaactcc 3660
tggggcctga caactcgaac tattggtgtt atgaccatgg ttcatgggga caacatgggt 3720
ttagtattac caccccgtgt agcatgtgtt caggtggtga ttattccttg tggcattacc 3780
aatgcacttt ctgaagaaga caaagaagcg ctgattgcaa aatgcaatga ttatcgaagg 3840
cgattactca gtgttaacat ccgcgttaga gctgatttac gagataatta ttctccaggt 3900
tggaaattca atcactggga gctcaaggga gttcccatta gacttgaagt tgggccacgt 3960
gatatgaaga gctgtcagtt tgtagccgtc agacgagata ctggagaaaa gctgacagtt 4020
gctgaaaatg aggcagagac taaacttcaa gctattttgg aagacatcca ggtcaccctt 4080
ttcacaaggg cttctgaaga ccttaagact catatggttg tggctaatac aatggaagac 4140
tttcagaaga tactagattc tggaaagatt gttcagattc cattctgtgg ggaaattgac 4200
tgtgaggact ggatcaaaaa gaccactgcc agggatcaag atcttgaacc tggtgctcca 4260
tccatgggag ctaaaagcct ttgcatcccc ttcaaaccac tctgtgaact gcagcctgga 4320
gccaaatgtg tctgtggcaa gaaccctgcc aagtactaca ccttatttgg tcgcagctac 4380
tga                                                               4383

<210> 167
<211> 50
<212> DNA
<213> Homo sapiens

<400> 167
tcagatttcc tccagaggcc agtgggttat cttggaagat gttgcaatgt            50

<210> 168
<211> 16
<212> PRT
<213> Homo sapiens

<400> 168
Arg Phe Pro Pro Glu Ala Ser Gly Leu Ser Trp Lys Met Leu Gln Cys
 1               5                  10                  15      


<210> 169
<211> 50
<212> DNA
<213> Homo sapiens

<400> 169
acatccaggt cacccttttc acaagattgt tcagattcca ttctgtgggg            50

<210> 170
<211> 16
<212> PRT
<213> Homo sapiens

<400> 170
Ile Gln Val Thr Leu Phe Thr Arg Leu Phe Arg Phe His Ser Val Gly
 1               5                  10                  15      


<210> 171
<211> 50
<212> DNA
<213> Homo sapiens

<400> 171
acttaaaact gaaaaagccc ctaagggatc aagatcttga acctggtgct            50

<210> 172
<211> 12
<212> PRT
<213> Homo sapiens

<400> 172
Leu Lys Thr Glu Lys Ala Pro Lys Gly Ser Arg Ser
 1               5                  10          


<210> 173
<211> 50
<212> DNA
<213> Homo sapiens

<400> 173
taccatggaa gaggcagcgg aagagggagg aacatcacat catttagggc            50

<210> 174
<211> 16
<212> PRT
<213> Homo sapiens

<400> 174
Thr Met Glu Glu Ala Ala Glu Glu Gly Gly Thr Ser His His Leu Gly
 1               5                  10                  15      


<210> 175
<211> 212
<212> PRT
<213> Homo sapiens

<400> 175
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile
    210         


<210> 176
<211> 636
<212> DNA
<213> Homo sapiens

<400> 176
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacatt                           636

<210> 177
<211> 868
<212> PRT
<213> Homo sapiens

<400> 177
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn
225                 230                 235                 240 
Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val
                245                 250                 255     
Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His
            260                 265                 270         
Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys
        275                 280                 285             
Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu
    290                 295                 300                 
Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu
305                 310                 315                 320 
Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys
                325                 330                 335     
Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg
            340                 345                 350         
Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly
        355                 360                 365             
Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val
    370                 375                 380                 
Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His
385                 390                 395                 400 
Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg
                405                 410                 415     
Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val
            420                 425                 430         
Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp
        435                 440                 445             
Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg
    450                 455                 460                 
Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser
465                 470                 475                 480 
Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn
                485                 490                 495     
Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys
            500                 505                 510         
Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys
        515                 520                 525             
Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val
    530                 535                 540                 
Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe
545                 550                 555                 560 
Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile
                565                 570                 575     
Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala
            580                 585                 590         
Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr
        595                 600                 605             
Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val
    610                 615                 620                 
Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp
625                 630                 635                 640 
Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu
                645                 650                 655     
Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu
            660                 665                 670         
Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser
        675                 680                 685             
Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp
    690                 695                 700                 
Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys
705                 710                 715                 720 
Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro
                725                 730                 735     
Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val
            740                 745                 750         
Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys
        755                 760                 765             
Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu
    770                 775                 780                 
Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys
785                 790                 795                 800 
Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser
                805                 810                 815     
Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala
            820                 825                 830         
Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala
        835                 840                 845             
Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr
    850                 855                 860                 
Lys Glu Lys Thr
865             


<210> 178
<211> 2604
<212> DNA
<213> Homo sapiens

<400> 178
atggcgacgc tctctctgac cgtgaattca ggagaccctc cgctaggagc tttgctggca 60
gtagaacacg tgaaagacga tgtcagcatt tccgttgaag aagggaaaga gaatattctt 120
catgtttctg aaaatgtgat attcacagat gtgaattcta tacttcgcta cttggctaga 180
gttgcaacta cagctgggtt atatggctct aatctgatgg aacatactga gattgatcac 240
tggttggagt tcagtgctac aaaattatct tcatgtgatt cctttacttc tacaattaat 300
gaactcaatc attgcctgtc tctgagaaca tacttagttg gaaactcctt gagtttagca 360
gatttatgtg tttgggccac cctaaaagga aatgctgcct ggcaagaaca gttgaaacag 420
aagaaagctc cagttcatgt aaaacgttgg tttggctttc ttgaagccca gcaggccttc 480
cagtcagtag gtaccaagtg ggatgtttca acaaccaaag ctcgagtggc acctgagaaa 540
aagcaagatg ttgggaaatt tgttgagctt ccaggtgcgg agatgggaaa ggttaccgtc 600
agatttcctc cagaggccag tggttactta cacattgggc atgcaaaagc tgctcttctg 660
aaccagcact accaggttaa ctttaaaggg aaactgatca tgagatttga tgacacaaat 720
cctgaaaaag aaaaggaaga ttttgagaag gttatcttgg aagatgttgc aatgttgcat 780
atcaaaccag atcaatttac ttatacttcg gatcattttg aaactataat gaagtatgca 840
gagaagctaa ttcaagaagg gaaggcttat gtggatgata ctcctgctga acagatgaaa 900
gcagaacgtg agcagaggat agactctaaa catagaaaaa accctattga gaagaatcta 960
caaatgtggg aagaaatgaa aaaagggagc cagtttggtc agtcctgttg tttgcgagca 1020
aaaattgaca tgagtagtaa caatggatgc atgagagatc caacccttta tcgctgcaaa 1080
attcaaccac atccaagaac tggaaataaa tacaatgttt atccaacata tgattttgcc 1140
tgccccatag ttgacagcat cgaaggtgtt acacatgccc tgagaacaac agaataccat 1200
gacagagatg agcagtttta ctggattatt gaagctttag gcataagaaa accatatatt 1260
tgggaatata gtcggctaaa tctcaacaac acagtgctat ccaaaagaaa actcacatgg 1320
tttgtcaatg aaggactagt agatggatgg gatgacccaa gatttcctac ggttcgtggt 1380
gtactgagaa gagggatgac agttgaagga ctgaaacagt ttattgctgc tcagggctcc 1440
tcacgttcag tcgtgaacat ggagtgggac aaaatctggg cgtttaacaa aaaggttatt 1500
gacccagtgg ctccacgata tgttgcatta ctgaagaaag aagtgatccc agtgaatgta 1560
cctgaagctc aggaggagat gaaagaagta gccaaacacc caaagaatcc tgaggttggc 1620
ttgaagcctg tgtggtatag tcccaaagtt ttcattgaag gtgctgatgc agagactttt 1680
tcggagggtg agatggttac atttataaat tggggcaacc tcaacattac aaaaatacac 1740
aaaaatgcag atggaaaaat catatctctt gatgcaaagt tgaatttgga aaacaaagac 1800
tacaagaaaa ccactaaggt cacttggctt gcagagacta cacatgctct tcctattcca 1860
gtaatctgtg tcacttatga gcacttgatc acaaagccag tgctaggaaa agacgaggac 1920
tttaagcagt atgtcaacaa gaacagtaag catgaagagc taatgctagg ggatccctgc 1980
cttaaggatt tgaaaaaagg agatattata caactccaga gaagaggatt cttcatatgt 2040
gatcaacctt atgaacctgt tagcccatat agttgcaagg aagccccgtg tgttttgata 2100
tacattcctg atgggcacac aaaggaaatg ccaacatcag ggtcaaagga aaagaccaaa 2160
gtagaagcca caaaaaatga gacctctgct ccttttaagg aaagaccaac accttctctg 2220
aataataatt gtactacatc tgaggattcc ttggtccttt acaatagagt ggctgttcaa 2280
ggagatgtgg ttcgtgaatt aaaagccaag aaagcaccaa aggaagatgt agatgcagct 2340
gtaaaacagc ttttgtcttt gaaagctgaa tataaggaga aaactggcca ggaatataaa 2400
cctggaaacc ctcctgctga aataggacag aatatttctt ctaattcctc agcaagtatt 2460
ctggaaagta aatctctgta tgatgaagtt gctgcacaag gggaggtggt tcgtaagcta 2520
aaagctgaaa aatcccctaa ggctaaaata aatgaagctg tagaatgctt actgtccctg 2580
aaggctcagt ataaagaaaa aact                                        2604

<210> 179
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      

<400> 179
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp
            20                  25                  30          
Pro Pro Leu Gly Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val
        35                  40                  45              
Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu
    50                  55                  60                  
Asn Val Ile Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg
65                  70                  75                  80  
Val Ala Thr Thr Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr
                85                  90                  95      
Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys
            100                 105                 110         
Asp Ser Phe Thr Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu
        115                 120                 125             
Arg Thr Tyr Leu Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val
    130                 135                 140                 
Trp Ala Thr Leu Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln
145                 150                 155                 160 
Lys Lys Ala Pro Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala
                165                 170                 175     
Gln Gln Ala Phe Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr
            180                 185                 190         
Lys Ala Arg Val Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val
        195                 200                 205             
Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro
    210                 215                 220                 
Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu
225                 230                 235                 240 
Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg
                245                 250                 255 


<210> 180
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      

<400> 180
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr
    210                 215                 220                 
Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Gly Lys Pro Ile Pro
225                 230                 235                 240 
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                245                 250                 255 


<210> 181
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      

<400> 181
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp
            20                  25                  30          
Pro Pro Leu Gly Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val
        35                  40                  45              
Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu
    50                  55                  60                  
Asn Val Ile Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg
65                  70                  75                  80  
Val Ala Thr Thr Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr
                85                  90                  95      
Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys
            100                 105                 110         
Asp Ser Phe Thr Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu
        115                 120                 125             
Arg Thr Tyr Leu Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val
    130                 135                 140                 
Trp Ala Thr Leu Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln
145                 150                 155                 160 
Lys Lys Ala Pro Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala
                165                 170                 175     
Gln Gln Ala Phe Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr
            180                 185                 190         
Lys Ala Arg Val Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val
        195                 200                 205             
Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro
    210                 215                 220                 
Glu Ala Ser Gly Tyr Leu His Ile
225                 230         


<210> 182
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      

<400> 182
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Tyr Leu His Ile Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
    210                 215                 220                 
Ser Thr His His His His His His
225                 230         


<210> 183
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      

<400> 183
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp
            20                  25                  30          
Pro Pro Leu Gly Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val
        35                  40                  45              
Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu
    50                  55                  60                  
Asn Val Ile Phe Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg
65                  70                  75                  80  
Val Ala Thr Thr Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr
                85                  90                  95      
Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys
            100                 105                 110         
Asp Ser Phe Thr Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu
        115                 120                 125             
Arg Thr Tyr Leu Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val
    130                 135                 140                 
Trp Ala Thr Leu Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln
145                 150                 155                 160 
Lys Lys Ala Pro Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala
                165                 170                 175     
Gln Gln Ala Phe Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr
            180                 185                 190         
Lys Ala Arg Val Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val
        195                 200                 205             
Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro
    210                 215                 220                 
Glu Ala Ser Gly Leu Ser Trp Lys Met Leu Gln Cys Cys Ile Ser Asn
225                 230                 235                 240 
Gln Ile Asn Leu Leu Ile Leu Arg Ile Ile Leu Lys Leu
                245                 250             


<210> 184
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      

<400> 184
Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly
 1               5                  10                  15      
Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val
            20                  25                  30          
Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe
        35                  40                  45              
Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr
    50                  55                  60                  
Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His
65                  70                  75                  80  
Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr
                85                  90                  95      
Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu
            100                 105                 110         
Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu
        115                 120                 125             
Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro
    130                 135                 140                 
Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe
145                 150                 155                 160 
Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val
                165                 170                 175     
Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly
            180                 185                 190         
Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly
        195                 200                 205             
Leu Ser Trp Lys Met Leu Gln Cys Cys Ile Ser Asn Gln Ile Asn Leu
    210                 215                 220                 
Leu Ile Leu Arg Ile Ile Leu Lys Leu Gly Lys Pro Ile Pro Asn Pro
225                 230                 235                 240 
Leu Leu Gly Leu Asp Ser Thr His His His His His His
                245                 250             


<210> 185
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      

<400> 185
gctaccctga gcctgacggt aaacagcggc gatccaccac tgggtgcgct gctggcagtg 60
gaacacgtta aagacgatgt gtccatcagc gtcgaagagg gcaaagaaaa tatcctgcat 120
gtgtccgaga atgtcatttt caccgatgtg aatagcattt tgcgttacct ggcacgtgtt 180
gcgacgaccg ctggcctgta cggttctaac ctgatggagc acactgaaat cgaccactgg 240
ctggagttct cggccacgaa actgagcagc tgcgacagct tcaccagcac tattaacgaa 300
ctgaaccatt gtctgtcttt gcgtacgtat ctggttggta acagcttgag cctggcggat 360
ctgtgcgtgt gggctacgtt gaaaggcaat gcggcgtggc aggagcagct gaaacaaaag 420
aaggcgccag tgcacgttaa gcgctggttt ggttttctgg aagcccaaca agcatttcag 480
agcgtcggta ccaagtggga tgttagcacc accaaggcac gcgttgcgcc ggagaagaaa 540
caggacgtcg gcaaattcgt cgagctgccg ggtgcggaaa tgggcaaagt taccgttcgt 600
tttccgccgg aggctagcgg ttatctgcac attggccatg caaaagccgc gctgctgaat 660
caacactacc aggtgaactt caagggtaag ctgatcatgc gttaatgact cgag       714

<210> 186
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      

<400> 186
gctaccctgt ctctgacggt aaacagcggc gacccaccac tgggtgcgct gctggcagtg 60
gagcatgtga aggacgacgt tagcatttct gttgaagagg gcaaagagaa cattttgcat 120
gtcagcgaga atgttatctt taccgatgtg aatagcattc tgcgttatct ggcacgtgtc 180
gcgaccaccg caggtctgta tggctccaac ctgatggaac acaccgagat cgatcattgg 240
ctggaattca gcgcaaccaa actgagcagc tgtgatagct ttacgagcac gattaatgaa 300
ttgaatcact gcctgtcgct gcgcacctac ctggtgggta actccctgag cttggcggac 360
ctgtgcgtct gggctactct gaaaggcaac gccgcgtggc aagagcaact gaaacagaag 420
aaggcgccgg tgcacgttaa acgttggttc ggtttcttgg aagctcagca agcatttcag 480
agcgtgggca ccaaatggga cgtgtctacc acgaaagccc gtgtcgcccc ggaaaagaag 540
caggatgttg gcaagttcgt tgagctgcca ggtgcggaaa tgggtaaggt tacggtccgc 600
tttccgccgg aggcgagcgg ttacctgcac atctaatgac tcgag                 645

<210> 187
<211> 708
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      

<400> 187
gctactctgt ctctgacggt aaacagcggc gacccaccac tgggtgctct gctggccgtg 60
gaacacgtca aagacgatgt ttctattagc gttgaagagg gtaaagaaaa tatcctgcat 120
gtgtctgaaa atgtgatctt taccgacgtt aacagcattc tgcgttactt ggcgcgcgtc 180
gctaccaccg caggtctgta tggtagcaac ctgatggagc acacggagat cgaccactgg 240
ctggagtttt cggcaacgaa gctgtccagc tgcgacagct tcaccagcac catcaatgag 300
ctgaaccact gtctgtcctt gcgtacgtac ttggtgggca atagcctgag cctggcggat 360
ctgtgcgtct gggcgaccct gaagggtaat gcagcgtggc aggagcaact gaaacagaag 420
aaagcaccag tgcatgttaa acgttggttc ggcttcttgg aagcgcaaca ggcctttcag 480
agcgtgggca ccaagtggga tgtcagcacc acgaaagcgc gcgttgcccc ggagaagaaa 540
caggatgttg gcaagttcgt tgagctgccg ggtgcggaga tgggtaaggt cactgtgcgc 600
tttccgccgg aagcgtccgg cctgagctgg aaaatgctgc aatgctgtat tagcaaccaa 660
attaacctgc tgatcttgcg tattatcctg aagctgtaat gactcgag              708

<210> 188
<211> 811
<212> PRT
<213> Homo sapiens

<400> 188
Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu
 1               5                  10                  15      
Lys Thr Lys Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys
            20                  25                  30          
Glu Arg Pro Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp
        35                  40                  45              
Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg
    50                  55                  60                  
Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val
65                  70                  75                  80  
Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln
                85                  90                  95      
Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser
            100                 105                 110         
Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu
        115                 120                 125             
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser
    130                 135                 140                 
Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
145                 150                 155                 160 
Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro
                165                 170                 175     
Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro
            180                 185                 190         
Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala
        195                 200                 205             
Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys
    210                 215                 220                 
Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln
225                 230                 235                 240 
Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly
                245                 250                 255     
Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu
            260                 265                 270         
Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro
        275                 280                 285             
Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly
    290                 295                 300                 
Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu
305                 310                 315                 320 
Glu Asn Leu Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met
                325                 330                 335     
Ile Glu Tyr His Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala
            340                 345                 350         
Tyr Ala Ile Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys
        355                 360                 365             
Lys Leu Gly Val Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser
    370                 375                 380                 
Ala Leu Glu Lys Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val
385                 390                 395                 400 
Ala Trp Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala
                405                 410                 415     
Ile Arg Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp
            420                 425                 430         
Val Gln Ser His Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn
        435                 440                 445             
Val Val Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
    450                 455                 460                 
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu
465                 470                 475                 480 
Ala Ala Glu Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr
                485                 490                 495     
Glu Glu Leu Leu Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys
            500                 505                 510         
Glu Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile
        515                 520                 525             
Ser Ala Ser Gly Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly
    530                 535                 540                 
Gln Asn Phe Ser Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile
545                 550                 555                 560 
Pro Gly Glu Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr
                565                 570                 575     
Arg Thr Ile Gly Val Met Thr Met Val His Gly Asp Asn Met Gly Leu
            580                 585                 590         
Val Leu Pro Pro Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys
        595                 600                 605             
Gly Ile Thr Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala
    610                 615                 620                 
Lys Cys Asn Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val
625                 630                 635                 640 
Arg Ala Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His
                645                 650                 655     
Trp Glu Leu Lys Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp
            660                 665                 670         
Met Lys Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys
        675                 680                 685             
Leu Thr Val Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu
    690                 695                 700                 
Glu Asp Ile Gln Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys
705                 710                 715                 720 
Thr His Met Val Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu
                725                 730                 735     
Asp Ser Gly Lys Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys
            740                 745                 750         
Glu Asp Trp Ile Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro
        755                 760                 765             
Gly Ala Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro
    770                 775                 780                 
Leu Cys Glu Leu Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro
785                 790                 795                 800 
Ala Lys Tyr Tyr Thr Leu Phe Gly Arg Ser Tyr
                805                 810     


<210> 189
<211> 2436
<212> DNA
<213> Homo sapiens

<400> 189
attcctgatg ggcacacaaa ggaaatgcca acatcagggt caaaggaaaa gaccaaagta 60
gaagccacaa aaaatgagac ctctgctcct tttaaggaaa gaccaacacc ttctctgaat 120
aataattgta ctacatctga ggattccttg gtcctttaca atagagtggc tgttcaagga 180
gatgtggttc gtgaattaaa agccaagaaa gcaccaaagg aagatgtaga tgcagctgta 240
aaacagcttt tgtctttgaa agctgaatat aaggagaaaa ctggccagga atataaacct 300
ggaaaccctc ctgctgaaat aggacagaat atttcttcta attcctcagc aagtattctg 360
gaaagtaaat ctctgtatga tgaagttgct gcacaagggg aggtggttcg taagctaaaa 420
gctgaaaaat cccctaaggc taaaataaat gaagctgtag aatgcttact gtccctgaag 480
gctcagtata aagaaaaaac tgggaaggag tacatacctg gtcagccccc attatctcaa 540
agttcggatt caagcccaac cagaaattct gaacctgctg gtttagaaac accagaagcg 600
aaagtacttt ttgacaaagt agcttctcaa ggggaagtag ttcggaaact taaaactgaa 660
aaagccccta aggatcaagt agatatagct gttcaagaac tccttcagct aaaggcacag 720
tacaagtctt tgataggagt agagtataag cctgtgtcgg ccactggagc tgaggacaaa 780
gataagaaga agaaagaaaa agaaaataaa tctgaaaagc agaataagcc tcagaaacaa 840
aatgatggcc aaaggaaaga cccttctaaa aaccaaggag gtgggctctc atcaagtgga 900
gcaggagaag ggcaggggcc taagaaacag accaggttgg gtcttgaggc aaaaaaagaa 960
gaaaatcttg ctgattggta ttctcaggtc atcacaaagt cagaaatgat tgaataccat 1020
gacataagtg gctgttatat tcttcgtccc tgggcctatg ccatttggga agccatcaag 1080
gacttttttg atgctgagat caagaaactt ggtgttgaaa actgctactt ccccatgttt 1140
gtgtctcaaa gtgcattaga gaaagagaag actcatgttg ctgactttgc cccagaggtt 1200
gcttgggtta caagatctgg caaaaccgag ctggcagaac caattgccat tcgtcctact 1260
agtgaaacag taatgtatcc tgcatatgca aaatgggtac agtcacacag agacctgccc 1320
atcaagctca atcagtggtg caatgtggtg cgttgggaat tcaagcatcc tcagcctttc 1380
ctacgtactc gtgaatttct ttggcaggaa gggcacagtg cttttgctac catggaagag 1440
gcagcggaag aggtcttgca gatacttgac ttatatgctc aggtatatga agaactcctg 1500
gcaattcctg ttgttaaagg aagaaagacg gaaaaggaaa aatttgcagg aggagactat 1560
acaactacaa tagaagcatt tatatctgct agtggaagag ctatccaggg aggaacatca 1620
catcatttag ggcagaattt ttccaaaatg tttgaaatcg tttttgaaga tccaaagata 1680
ccaggagaga agcaatttgc ctatcaaaac tcctggggcc tgacaactcg aactattggt 1740
gttatgacca tggttcatgg ggacaacatg ggtttagtat taccaccccg tgtagcatgt 1800
gttcaggtgg tgattattcc ttgtggcatt accaatgcac tttctgaaga agacaaagaa 1860
gcgctgattg caaaatgcaa tgattatcga aggcgattac tcagtgttaa catccgcgtt 1920
agagctgatt tacgagataa ttattctcca ggttggaaat tcaatcactg ggagctcaag 1980
ggagttccca ttagacttga agttgggcca cgtgatatga agagctgtca gtttgtagcc 2040
gtcagacgag atactggaga aaagctgaca gttgctgaaa atgaggcaga gactaaactt 2100
caagctattt tggaagacat ccaggtcacc cttttcacaa gggcttctga agaccttaag 2160
actcatatgg ttgtggctaa tacaatggaa gactttcaga agatactaga ttctggaaag 2220
attgttcaga ttccattctg tggggaaatt gactgtgagg actggatcaa aaagaccact 2280
gccagggatc aagatcttga acctggtgct ccatccatgg gagctaaaag cctttgcatc 2340
cccttcaaac cactctgtga actgcagcct ggagccaaat gtgtctgtgg caagaaccct 2400
gccaagtact acaccttatt tggtcgcagc tactga                           2436

<210> 190
<211> 645
<212> PRT
<213> Homo sapiens

<400> 190
Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser
 1               5                  10                  15      
Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro
            20                  25                  30          
Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val
        35                  40                  45              
Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala
    50                  55                  60                  
Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly
65                  70                  75                  80  
Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys
                85                  90                  95      
Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln
            100                 105                 110         
Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly
        115                 120                 125             
Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln
    130                 135                 140                 
Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp
145                 150                 155                 160 
Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile
                165                 170                 175     
Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala
            180                 185                 190         
Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn
        195                 200                 205             
Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys
    210                 215                 220                 
Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser
225                 230                 235                 240 
Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu
                245                 250                 255     
Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp
            260                 265                 270         
Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe
        275                 280                 285             
Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu
    290                 295                 300                 
Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu
305                 310                 315                 320 
Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile
                325                 330                 335     
Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly
            340                 345                 350         
Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala
        355                 360                 365             
Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met
    370                 375                 380                 
Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe
385                 390                 395                 400 
Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met
                405                 410                 415     
Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val
            420                 425                 430         
Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu
        435                 440                 445             
Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg
    450                 455                 460                 
Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp
465                 470                 475                 480 
Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val
                485                 490                 495     
Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe
            500                 505                 510         
Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn
        515                 520                 525             
Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr
    530                 535                 540                 
Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala
545                 550                 555                 560 
Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val
                565                 570                 575     
Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys
            580                 585                 590         
Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly
        595                 600                 605             
Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro
    610                 615                 620                 
Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu
625                 630                 635                 640 
Phe Gly Arg Ser Tyr
                645 


<210> 191
<211> 1938
<212> DNA
<213> Homo sapiens

<400> 191
actgggaagg agtacatacc tggtcagccc ccattatctc aaagttcgga ttcaagccca 60
accagaaatt ctgaacctgc tggtttagaa acaccagaag cgaaagtact ttttgacaaa 120
gtagcttctc aaggggaagt agttcggaaa cttaaaactg aaaaagcccc taaggatcaa 180
gtagatatag ctgttcaaga actccttcag ctaaaggcac agtacaagtc tttgatagga 240
gtagagtata agcctgtgtc ggccactgga gctgaggaca aagataagaa gaagaaagaa 300
aaagaaaata aatctgaaaa gcagaataag cctcagaaac aaaatgatgg ccaaaggaaa 360
gacccttcta aaaaccaagg aggtgggctc tcatcaagtg gagcaggaga agggcagggg 420
cctaagaaac agaccaggtt gggtcttgag gcaaaaaaag aagaaaatct tgctgattgg 480
tattctcagg tcatcacaaa gtcagaaatg attgaatacc atgacataag tggctgttat 540
attcttcgtc cctgggccta tgccatttgg gaagccatca aggacttttt tgatgctgag 600
atcaagaaac ttggtgttga aaactgctac ttccccatgt ttgtgtctca aagtgcatta 660
gagaaagaga agactcatgt tgctgacttt gccccagagg ttgcttgggt tacaagatct 720
ggcaaaaccg agctggcaga accaattgcc attcgtccta ctagtgaaac agtaatgtat 780
cctgcatatg caaaatgggt acagtcacac agagacctgc ccatcaagct caatcagtgg 840
tgcaatgtgg tgcgttggga attcaagcat cctcagcctt tcctacgtac tcgtgaattt 900
ctttggcagg aagggcacag tgcttttgct accatggaag aggcagcgga agaggtcttg 960
cagatacttg acttatatgc tcaggtatat gaagaactcc tggcaattcc tgttgttaaa 1020
ggaagaaaga cggaaaagga aaaatttgca ggaggagact atacaactac aatagaagca 1080
tttatatctg ctagtggaag agctatccag ggaggaacat cacatcattt agggcagaat 1140
ttttccaaaa tgtttgaaat cgtttttgaa gatccaaaga taccaggaga gaagcaattt 1200
gcctatcaaa actcctgggg cctgacaact cgaactattg gtgttatgac catggttcat 1260
ggggacaaca tgggtttagt attaccaccc cgtgtagcat gtgttcaggt ggtgattatt 1320
ccttgtggca ttaccaatgc actttctgaa gaagacaaag aagcgctgat tgcaaaatgc 1380
aatgattatc gaaggcgatt actcagtgtt aacatccgcg ttagagctga tttacgagat 1440
aattattctc caggttggaa attcaatcac tgggagctca agggagttcc cattagactt 1500
gaagttgggc cacgtgatat gaagagctgt cagtttgtag ccgtcagacg agatactgga 1560
gaaaagctga cagttgctga aaatgaggca gagactaaac ttcaagctat tttggaagac 1620
atccaggtca cccttttcac aagggcttct gaagacctta agactcatat ggttgtggct 1680
aatacaatgg aagactttca gaagatacta gattctggaa agattgttca gattccattc 1740
tgtggggaaa ttgactgtga ggactggatc aaaaagacca ctgccaggga tcaagatctt 1800
gaacctggtg ctccatccat gggagctaaa agcctttgca tccccttcaa accactctgt 1860
gaactgcagc ctggagccaa atgtgtctgt ggcaagaacc ctgccaagta ctacacctta 1920
tttggtcgca gctactga                                               1938

<210> 192
<211> 563
<212> PRT
<213> Homo sapiens

<400> 192
Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys
 1               5                  10                  15      
Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln
            20                  25                  30          
Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu
        35                  40                  45              
Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg
    50                  55                  60                  
Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser
65                  70                  75                  80  
Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly
                85                  90                  95      
Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys
            100                 105                 110         
Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys Tyr
        115                 120                 125             
Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr His
    130                 135                 140                 
Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly Lys
145                 150                 155                 160 
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val
                165                 170                 175     
Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu Pro
            180                 185                 190         
Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys His
        195                 200                 205             
Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His
    210                 215                 220                 
Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile
225                 230                 235                 240 
Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val
                245                 250                 255     
Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr
            260                 265                 270         
Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln
        275                 280                 285             
Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu
    290                 295                 300                 
Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr
305                 310                 315                 320 
Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met
                325                 330                 335     
Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys
            340                 345                 350         
Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser Glu
        355                 360                 365             
Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg Arg
    370                 375                 380                 
Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn Tyr
385                 390                 395                 400 
Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro Ile
                405                 410                 415     
Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val Ala
            420                 425                 430         
Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala
        435                 440                 445             
Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe
    450                 455                 460                 
Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn Thr
465                 470                 475                 480 
Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile
                485                 490                 495     
Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr
            500                 505                 510         
Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys
        515                 520                 525             
Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala
    530                 535                 540                 
Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly
545                 550                 555                 560 
Arg Ser Tyr
            


<210> 193
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 193
tataagcctg tgtcggccac tggagctgag gacaaagata agaagaagaa agaaaaagaa 60
aataaatctg aaaagcagaa taagcctcag aaacaaaatg atggccaaag gaaagaccct 120
tctaaaaacc aaggaggtgg gctctcatca agtggagcag gagaagggca ggggcctaag 180
aaacagacca ggttgggtct tgaggcaaaa aaagaagaaa atcttgctga ttggtattct 240
caggtcatca caaagtcaga aatgattgaa taccatgaca taagtggctg ttatattctt 300
cgtccctggg cctatgccat ttgggaagcc atcaaggact tttttgatgc tgagatcaag 360
aaacttggtg ttgaaaactg ctacttcccc atgtttgtgt ctcaaagtgc attagagaaa 420
gagaagactc atgttgctga ctttgcccca gaggttgctt gggttacaag atctggcaaa 480
accgagctgg cagaaccaat tgccattcgt cctactagtg aaacagtaat gtatcctgca 540
tatgcaaaat gggtacagtc acacagagac ctgcccatca agctcaatca gtggtgcaat 600
gtggtgcgtt gggaattcaa gcatcctcag cctttcctac gtactcgtga atttctttgg 660
caggaagggc acagtgcttt tgctaccatg gaagaggcag cggaagaggt cttgcagata 720
cttgacttat atgctcaggt atatgaagaa ctcctggcaa ttcctgttgt taaaggaaga 780
aagacggaaa aggaaaaatt tgcaggagga gactatacaa ctacaataga agcatttata 840
tctgctagtg gaagagctat ccagggagga acatcacatc atttagggca gaatttttcc 900
aaaatgtttg aaatcgtttt tgaagatcca aagataccag gagagaagca atttgcctat 960
caaaactcct ggggcctgac aactcgaact attggtgtta tgaccatggt tcatggggac 1020
aacatgggtt tagtattacc accccgtgta gcatgtgttc aggtggtgat tattccttgt 1080
ggcattacca atgcactttc tgaagaagac aaagaagcgc tgattgcaaa atgcaatgat 1140
tatcgaaggc gattactcag tgttaacatc cgcgttagag ctgatttacg agataattat 1200
tctccaggtt ggaaattcaa tcactgggag ctcaagggag ttcccattag acttgaagtt 1260
gggccacgtg atatgaagag ctgtcagttt gtagccgtca gacgagatac tggagaaaag 1320
ctgacagttg ctgaaaatga ggcagagact aaacttcaag ctattttgga agacatccag 1380
gtcacccttt tcacaagggc ttctgaagac cttaagactc atatggttgt ggctaataca 1440
atggaagact ttcagaagat actagattct ggaaagattg ttcagattcc attctgtggg 1500
gaaattgact gtgaggactg gatcaaaaag accactgcca gggatcaaga tcttgaacct 1560
ggtgctccat ccatgggagc taaaagcctt tgcatcccct tcaaaccact ctgtgaactg 1620
cagcctggag ccaaatgtgt ctgtggcaag aaccctgcca agtactacac cttatttggt 1680
cgcagctact ga                                                     1692

<210> 194
<211> 611
<212> PRT
<213> Homo sapiens

<400> 194
Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg Lys
 1               5                  10                  15      
Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val Gln
            20                  25                  30          
Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val Glu
        35                  40                  45              
Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys
    50                  55                  60                  
Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln
65                  70                  75                  80  
Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu
                85                  90                  95      
Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg
            100                 105                 110         
Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser
        115                 120                 125             
Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly
    130                 135                 140                 
Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys
145                 150                 155                 160 
Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys Tyr
                165                 170                 175     
Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr His
            180                 185                 190         
Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly Lys
        195                 200                 205             
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val
    210                 215                 220                 
Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu Pro
225                 230                 235                 240 
Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys His
                245                 250                 255     
Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His
            260                 265                 270         
Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile
        275                 280                 285             
Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val
    290                 295                 300                 
Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr
305                 310                 315                 320 
Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln
                325                 330                 335     
Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu
            340                 345                 350         
Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr
        355                 360                 365             
Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met
    370                 375                 380                 
Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys
385                 390                 395                 400 
Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser Glu
                405                 410                 415     
Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg Arg
            420                 425                 430         
Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn Tyr
        435                 440                 445             
Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro Ile
    450                 455                 460                 
Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val Ala
465                 470                 475                 480 
Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala
                485                 490                 495     
Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe
            500                 505                 510         
Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn Thr
        515                 520                 525             
Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile
    530                 535                 540                 
Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr
545                 550                 555                 560 
Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys
                565                 570                 575     
Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala
            580                 585                 590         
Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly
        595                 600                 605             
Arg Ser Tyr
    610     


<210> 195
<211> 1836
<212> DNA
<213> Homo sapiens

<400> 195
aaagtacttt ttgacaaagt agcttctcaa ggggaagtag ttcggaaact taaaactgaa 60
aaagccccta aggatcaagt agatatagct gttcaagaac tccttcagct aaaggcacag 120
tacaagtctt tgataggagt agagtataag cctgtgtcgg ccactggagc tgaggacaaa 180
gataagaaga agaaagaaaa agaaaataaa tctgaaaagc agaataagcc tcagaaacaa 240
aatgatggcc aaaggaaaga cccttctaaa aaccaaggag gtgggctctc atcaagtgga 300
gcaggagaag ggcaggggcc taagaaacag accaggttgg gtcttgaggc aaaaaaagaa 360
gaaaatcttg ctgattggta ttctcaggtc atcacaaagt cagaaatgat tgaataccat 420
gacataagtg gctgttatat tcttcgtccc tgggcctatg ccatttggga agccatcaag 480
gacttttttg atgctgagat caagaaactt ggtgttgaaa actgctactt ccccatgttt 540
gtgtctcaaa gtgcattaga gaaagagaag actcatgttg ctgactttgc cccagaggtt 600
gcttgggtta caagatctgg caaaaccgag ctggcagaac caattgccat tcgtcctact 660
agtgaaacag taatgtatcc tgcatatgca aaatgggtac agtcacacag agacctgccc 720
atcaagctca atcagtggtg caatgtggtg cgttgggaat tcaagcatcc tcagcctttc 780
ctacgtactc gtgaatttct ttggcaggaa gggcacagtg cttttgctac catggaagag 840
gcagcggaag aggtcttgca gatacttgac ttatatgctc aggtatatga agaactcctg 900
gcaattcctg ttgttaaagg aagaaagacg gaaaaggaaa aatttgcagg aggagactat 960
acaactacaa tagaagcatt tatatctgct agtggaagag ctatccaggg aggaacatca 1020
catcatttag ggcagaattt ttccaaaatg tttgaaatcg tttttgaaga tccaaagata 1080
ccaggagaga agcaatttgc ctatcaaaac tcctggggcc tgacaactcg aactattggt 1140
gttatgacca tggttcatgg ggacaacatg ggtttagtat taccaccccg tgtagcatgt 1200
gttcaggtgg tgattattcc ttgtggcatt accaatgcac tttctgaaga agacaaagaa 1260
gcgctgattg caaaatgcaa tgattatcga aggcgattac tcagtgttaa catccgcgtt 1320
agagctgatt tacgagataa ttattctcca ggttggaaat tcaatcactg ggagctcaag 1380
ggagttccca ttagacttga agttgggcca cgtgatatga agagctgtca gtttgtagcc 1440
gtcagacgag atactggaga aaagctgaca gttgctgaaa atgaggcaga gactaaactt 1500
caagctattt tggaagacat ccaggtcacc cttttcacaa gggcttctga agaccttaag 1560
actcatatgg ttgtggctaa tacaatggaa gactttcaga agatactaga ttctggaaag 1620
attgttcaga ttccattctg tggggaaatt gactgtgagg actggatcaa aaagaccact 1680
gccagggatc aagatcttga acctggtgct ccatccatgg gagctaaaag cctttgcatc 1740
cccttcaaac cactctgtga actgcagcct ggagccaaat gtgtctgtgg caagaaccct 1800
gccaagtact acaccttatt tggtcgcagc tactga                           1836

<210> 196
<211> 371
<212> PRT
<213> Homo sapiens

<400> 196
Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys His
 1               5                  10                  15      
Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His
            20                  25                  30          
Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile
        35                  40                  45              
Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val
    50                  55                  60                  
Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr
65                  70                  75                  80  
Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln
                85                  90                  95      
Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu
            100                 105                 110         
Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr
        115                 120                 125             
Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met
    130                 135                 140                 
Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys
145                 150                 155                 160 
Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser Glu
                165                 170                 175     
Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg Arg
            180                 185                 190         
Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn Tyr
        195                 200                 205             
Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro Ile
    210                 215                 220                 
Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val Ala
225                 230                 235                 240 
Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala
                245                 250                 255     
Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe
            260                 265                 270         
Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn Thr
        275                 280                 285             
Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile
    290                 295                 300                 
Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr
305                 310                 315                 320 
Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys
                325                 330                 335     
Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala
            340                 345                 350         
Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly
        355                 360                 365             
Arg Ser Tyr
    370     


<210> 197
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 197
atcaagctca atcagtggtg caatgtggtg cgttgggaat tcaagcatcc tcagcctttc 60
ctacgtactc gtgaatttct ttggcaggaa gggcacagtg cttttgctac catggaagag 120
gcagcggaag aggtcttgca gatacttgac ttatatgctc aggtatatga agaactcctg 180
gcaattcctg ttgttaaagg aagaaagacg gaaaaggaaa aatttgcagg aggagactat 240
acaactacaa tagaagcatt tatatctgct agtggaagag ctatccaggg aggaacatca 300
catcatttag ggcagaattt ttccaaaatg tttgaaatcg tttttgaaga tccaaagata 360
ccaggagaga agcaatttgc ctatcaaaac tcctggggcc tgacaactcg aactattggt 420
gttatgacca tggttcatgg ggacaacatg ggtttagtat taccaccccg tgtagcatgt 480
gttcaggtgg tgattattcc ttgtggcatt accaatgcac tttctgaaga agacaaagaa 540
gcgctgattg caaaatgcaa tgattatcga aggcgattac tcagtgttaa catccgcgtt 600
agagctgatt tacgagataa ttattctcca ggttggaaat tcaatcactg ggagctcaag 660
ggagttccca ttagacttga agttgggcca cgtgatatga agagctgtca gtttgtagcc 720
gtcagacgag atactggaga aaagctgaca gttgctgaaa atgaggcaga gactaaactt 780
caagctattt tggaagacat ccaggtcacc cttttcacaa gggcttctga agaccttaag 840
actcatatgg ttgtggctaa tacaatggaa gactttcaga agatactaga ttctggaaag 900
attgttcaga ttccattctg tggggaaatt gactgtgagg actggatcaa aaagaccact 960
gccagggatc aagatcttga acctggtgct ccatccatgg gagctaaaag cctttgcatc 1020
cccttcaaac cactctgtga actgcagcct ggagccaaat gtgtctgtgg caagaaccct 1080
gccaagtact acaccttatt tggtcgcagc tactga                           1116

<210> 198
<211> 23
<212> PRT
<213> Mus musculus

<400> 198
Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala Thr Ala Glu Asp
 1               5                  10                  15      
Ser Ser Val Leu Tyr Ser Arg
            20              


<210> 199
<211> 59
<212> PRT
<213> Mus musculus

<400> 199
Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala
 1               5                  10                  15      
Pro Lys Glu Asp Ile Asp Ala Ala Val Lys Gln Leu Leu Thr Leu Lys
            20                  25                  30          
Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro
        35                  40                  45              
Ser Ala Ala Ala Val Gln Thr Val Ser Thr Lys
    50                  55                  


<210> 200
<211> 14
<212> PRT
<213> Mus musculus

<400> 200
Ser Ser Ser Asn Thr Val Glu Ser Thr Ser Leu Tyr Asn Lys
 1               5                  10                  


<210> 201
<211> 78
<212> PRT
<213> Mus musculus

<400> 201
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala
 1               5                  10                  15      
Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
            20                  25                  30          
Ala Glu Tyr Lys Glu Lys Thr Gly Lys Asp Tyr Val Pro Gly Gln Pro
        35                  40                  45              
Pro Ala Ser Gln Asn Ser His Ser Asn Pro Val Ser Asn Ala Gln Pro
    50                  55                  60                  
Ala Gly Ala Glu Lys Pro Glu Ala Lys Val Leu Phe Asp Arg
65                  70                  75              


<210> 202
<211> 9
<212> PRT
<213> Mus musculus

<400> 202
Val Ala Cys Gln Gly Glu Val Val Arg
 1               5                  


<210> 203
<211> 6
<212> PRT
<213> Mus musculus

<400> 203
Lys Leu Lys Ala Glu Lys
 1               5      


<210> 204
<211> 17
<212> PRT
<213> Mus musculus

<400> 204
Ala Ser Lys Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln Leu
 1               5                  10                  15      
Lys
    


<210> 205
<211> 4
<212> PRT
<213> Mus musculus

<400> 205
Ala Gln Tyr Lys
 1              


<210> 206
<211> 20
<212> PRT
<213> Mus musculus

<400> 206
Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu
 1               5                  10                  15      
Asp Lys Asp Lys
            20  


<210> 207
<211> 28
<212> PRT
<213> Mus musculus

<400> 207
Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln
 1               5                  10                  15      
Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys
            20                  25              


<210> 208
<211> 18
<212> PRT
<213> Mus musculus

<400> 208
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 209
<211> 10
<212> PRT
<213> Mus musculus

<400> 209
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 210
<211> 15
<212> PRT
<213> Mus musculus

<400> 210
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 211
<211> 36
<212> PRT
<213> Mus musculus

<400> 211
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 212
<211> 19
<212> PRT
<213> Mus musculus

<400> 212
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 213
<211> 15
<212> PRT
<213> Mus musculus

<400> 213
Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg
 1               5                  10                  15  


<210> 214
<211> 14
<212> PRT
<213> Mus musculus

<400> 214
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu
 1               5                  10                  


<210> 215
<211> 20
<212> PRT
<213> Mus musculus

<400> 215
Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp
 1               5                  10                  15      
Leu Ala Val Arg
            20  


<210> 216
<211> 9
<212> PRT
<213> Mus musculus

<400> 216
Leu Asn Gln Trp Cys Asn Val Val Arg
 1               5                  


<210> 217
<211> 13
<212> PRT
<213> Mus musculus

<400> 217
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
 1               5                  10              


<210> 218
<211> 22
<212> PRT
<213> Mus musculus

<400> 218
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu
 1               5                  10                  15      
Ala Ala Asp Glu Val Leu
            20          


<210> 219
<211> 8
<212> PRT
<213> Mus musculus

<400> 219
Gln Ile Leu Glu Leu Tyr Ala Arg
 1               5              


<210> 220
<211> 12
<212> PRT
<213> Mus musculus

<400> 220
Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val Arg
 1               5                  10          


<210> 221
<211> 6
<212> PRT
<213> Mus musculus

<400> 221
Gly Arg Lys Thr Glu Lys
 1               5      


<210> 222
<211> 37
<212> PRT
<213> Mus musculus

<400> 222
Glu Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile
 1               5                  10                  15      
Ser Ala Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly
            20                  25                  30          
Gln Asn Phe Ser Lys
        35          


<210> 223
<211> 59
<212> PRT
<213> Mus musculus

<400> 223
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln
 1               5                  10                  15      
Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val
            20                  25                  30          
Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg
        35                  40                  45              
Val Ala Ser Val Gln Val Val Val Ile Pro Cys
    50                  55                  


<210> 224
<211> 17
<212> PRT
<213> Mus musculus

<400> 224
Gly Ile Thr Asn Ala Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala
 1               5                  10                  15      
Lys
    


<210> 225
<211> 77
<212> PRT
<213> Mus musculus

<400> 225
Cys Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg
 1               5                  10                  15      
Val Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp
            20                  25                  30          
Glu Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met
        35                  40                  45              
Lys Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu
    50                  55                  60                  
Thr Ile Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys
65                  70                  75          


<210> 226
<211> 12
<212> PRT
<213> Mus musculus

<400> 226
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 227
<211> 26
<212> PRT
<213> Mus musculus

<400> 227
Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ser Asn Thr Leu Glu
 1               5                  10                  15      
Asp Phe Gln Lys Val Leu Asp Ala Gly Lys
            20                  25      


<210> 228
<211> 18
<212> PRT
<213> Mus musculus

<400> 228
Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
 1               5                  10                  15      
Lys Lys
        


<210> 229
<211> 4
<212> PRT
<213> Mus musculus

<400> 229
Met Thr Ala Arg
 1              


<210> 230
<211> 36
<212> PRT
<213> Mus musculus

<400> 230
Asp Gln Asp Val Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu
 1               5                  10                  15      
Cys Ile Pro Phe Asn Pro Leu Cys Glu Leu Gln Pro Gly Ala Met Cys
            20                  25                  30          
Val Cys Gly Lys
        35      


<210> 231
<211> 766
<212> PRT
<213> Mus musculus

<400> 231
Glu Arg Pro Ala Pro Ala Val Ser Ser Thr Cys Ala Thr Ala Glu Asp
 1               5                  10                  15      
Ser Ser Val Leu Tyr Ser Arg Val Ala Val Gln Gly Asp Val Val Arg
            20                  25                  30          
Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Ile Asp Ala Ala Val
        35                  40                  45              
Lys Gln Leu Leu Thr Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln
    50                  55                  60                  
Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val Gln Thr Val Ser
65                  70                  75                  80  
Thr Lys Ser Ser Ser Asn Thr Val Glu Ser Thr Ser Leu Tyr Asn Lys
                85                  90                  95      
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala
            100                 105                 110         
Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
        115                 120                 125             
Ala Glu Tyr Lys Glu Lys Thr Gly Lys Asp Tyr Val Pro Gly Gln Pro
    130                 135                 140                 
Pro Ala Ser Gln Asn Ser His Ser Asn Pro Val Ser Asn Ala Gln Pro
145                 150                 155                 160 
Ala Gly Ala Glu Lys Pro Glu Ala Lys Val Leu Phe Asp Arg Val Ala
                165                 170                 175     
Cys Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala Ser Lys
            180                 185                 190         
Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln
        195                 200                 205             
Tyr Lys Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly
    210                 215                 220                 
Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu
225                 230                 235                 240 
Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser
                245                 250                 255     
Ser Lys Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly
            260                 265                 270         
Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu
        275                 280                 285             
Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met
    290                 295                 300                 
Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ser
305                 310                 315                 320 
Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys
                325                 330                 335     
Lys Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala
            340                 345                 350         
Ala Leu Glu Lys Glu Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val
        355                 360                 365             
Ala Trp Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala
    370                 375                 380                 
Ile Arg Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp
385                 390                 395                 400 
Val Gln Ser His Arg Asp Leu Ala Val Arg Leu Asn Gln Trp Cys Asn
                405                 410                 415     
Val Val Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
            420                 425                 430         
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu
        435                 440                 445             
Ala Ala Asp Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr
    450                 455                 460                 
Glu Glu Leu Leu Ala Ile Pro Val Val Arg Gly Arg Lys Thr Glu Lys
465                 470                 475                 480 
Glu Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile
                485                 490                 495     
Ser Ala Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly
            500                 505                 510         
Gln Asn Phe Ser Lys Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr
        515                 520                 525             
Pro Gly Glu Lys Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr
    530                 535                 540                 
Arg Thr Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu
545                 550                 555                 560 
Val Leu Pro Pro Arg Val Ala Ser Val Gln Val Val Val Ile Pro Cys
                565                 570                 575     
Gly Ile Thr Asn Ala Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala
            580                 585                 590         
Lys Cys Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val
        595                 600                 605             
Arg Val Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His
    610                 615                 620                 
Trp Glu Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp
625                 630                 635                 640 
Met Lys Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys
                645                 650                 655     
Leu Thr Ile Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys Val Leu
            660                 665                 670         
Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys
        675                 680                 685             
Thr His Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys Val Leu
    690                 695                 700                 
Asp Ala Gly Lys Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys
705                 710                 715                 720 
Glu Asp Trp Ile Lys Lys Met Thr Ala Arg Asp Gln Asp Val Glu Pro
                725                 730                 735     
Gly Ala Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Asn Pro
            740                 745                 750         
Leu Cys Glu Leu Gln Pro Gly Ala Met Cys Val Cys Gly Lys
        755                 760                 765     


<210> 232
<211> 18
<212> PRT
<213> Mus musculus

<400> 232
Ser Asn Pro Val Ser Asn Ala Gln Pro Ala Gly Ala Glu Lys Pro Glu
 1               5                  10                  15      
Ala Lys
        


<210> 233
<211> 20
<212> PRT
<213> Mus musculus

<400> 233
Val Leu Phe Asp Arg Val Ala Cys Gln Gly Glu Val Val Arg Lys Leu
 1               5                  10                  15      
Lys Ala Glu Lys
            20  


<210> 234
<211> 17
<212> PRT
<213> Mus musculus

<400> 234
Ala Ser Lys Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln Leu
 1               5                  10                  15      
Lys
    


<210> 235
<211> 4
<212> PRT
<213> Mus musculus

<400> 235
Ala Gln Tyr Lys
 1              


<210> 236
<211> 18
<212> PRT
<213> Mus musculus

<400> 236
Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu
 1               5                  10                  15      
Asp Lys
        


<210> 237
<211> 30
<212> PRT
<213> Mus musculus

<400> 237
Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys
 1               5                  10                  15      
Pro Gln Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys
            20                  25                  30  


<210> 238
<211> 18
<212> PRT
<213> Mus musculus

<400> 238
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 239
<211> 10
<212> PRT
<213> Mus musculus

<400> 239
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 240
<211> 15
<212> PRT
<213> Mus musculus

<400> 240
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 241
<211> 36
<212> PRT
<213> Mus musculus

<400> 241
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 242
<211> 19
<212> PRT
<213> Mus musculus

<400> 242
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 243
<211> 15
<212> PRT
<213> Mus musculus

<400> 243
Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg
 1               5                  10                  15  


<210> 244
<211> 12
<212> PRT
<213> Mus musculus

<400> 244
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr
 1               5                  10          


<210> 245
<211> 74
<212> PRT
<213> Mus musculus

<400> 245
Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His
 1               5                  10                  15      
Arg Asp Leu Ala Val Arg Leu Asn Gln Trp Cys Asn Val Val Arg Trp
            20                  25                  30          
Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp
        35                  40                  45              
Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu Ala Ala Asp Glu
    50                  55                  60                  
Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg
65                  70                  


<210> 246
<211> 12
<212> PRT
<213> Mus musculus

<400> 246
Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val Arg
 1               5                  10          


<210> 247
<211> 8
<212> PRT
<213> Mus musculus

<400> 247
Gly Arg Lys Thr Glu Lys Glu Lys
 1               5              


<210> 248
<211> 35
<212> PRT
<213> Mus musculus

<400> 248
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
 1               5                  10                  15      
Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn
            20                  25                  30          
Phe Ser Lys
        35  


<210> 249
<211> 153
<212> PRT
<213> Mus musculus

<400> 249
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln
 1               5                  10                  15      
Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val
            20                  25                  30          
Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg
        35                  40                  45              
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
    50                  55                  60                  
Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys Asn Glu Tyr
65                  70                  75                  80  
Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val Asp Leu Arg
                85                  90                  95      
Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly
            100                 105                 110         
Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln
        115                 120                 125             
Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu
    130                 135                 140                 
Lys Glu Ala Glu Ala Lys Leu Glu Lys
145                 150             


<210> 250
<211> 12
<212> PRT
<213> Mus musculus

<400> 250
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 251
<211> 26
<212> PRT
<213> Mus musculus

<400> 251
Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ser Asn Thr Leu Glu
 1               5                  10                  15      
Asp Phe Gln Lys Val Leu Asp Ala Gly Lys
            20                  25      


<210> 252
<211> 18
<212> PRT
<213> Mus musculus

<400> 252
Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
 1               5                  10                  15      
Lys Lys
        


<210> 253
<211> 18
<212> PRT
<213> Mus musculus

<400> 253
Met Thr Ala Arg Asp Gln Asp Val Glu Pro Gly Ala Pro Ser Met Gly
 1               5                  10                  15      
Ala Lys
        


<210> 254
<211> 22
<212> PRT
<213> Mus musculus

<400> 254
Ser Leu Cys Ile Pro Phe Asn Pro Leu Cys Glu Leu Gln Pro Gly Ala
 1               5                  10                  15      
Met Cys Val Cys Gly Lys
            20          


<210> 255
<211> 20
<212> PRT
<213> Mus musculus

<400> 255
Ser His Ser Asn Pro Val Ser Asn Ala Gln Pro Ala Gly Ala Glu Lys
 1               5                  10                  15      
Pro Glu Ala Lys
            20  


<210> 256
<211> 20
<212> PRT
<213> Mus musculus

<400> 256
Val Leu Phe Asp Arg Val Ala Cys Gln Gly Glu Val Val Arg Lys Leu
 1               5                  10                  15      
Lys Ala Glu Lys
            20  


<210> 257
<211> 17
<212> PRT
<213> Mus musculus

<400> 257
Ala Ser Lys Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln Leu
 1               5                  10                  15      
Lys
    


<210> 258
<211> 52
<212> PRT
<213> Mus musculus

<400> 258
Ala Gln Tyr Lys Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala
 1               5                  10                  15      
Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys
            20                  25                  30          
Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Gly Lys
        35                  40                  45              
Asp Ser Ser Lys
    50          


<210> 259
<211> 18
<212> PRT
<213> Mus musculus

<400> 259
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 260
<211> 10
<212> PRT
<213> Mus musculus

<400> 260
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 261
<211> 15
<212> PRT
<213> Mus musculus

<400> 261
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 262
<211> 36
<212> PRT
<213> Mus musculus

<400> 262
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 263
<211> 19
<212> PRT
<213> Mus musculus

<400> 263
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 264
<211> 15
<212> PRT
<213> Mus musculus

<400> 264
Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg
 1               5                  10                  15  


<210> 265
<211> 37
<212> PRT
<213> Mus musculus

<400> 265
Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser
 1               5                  10                  15      
Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg
            20                  25                  30          
Asp Leu Ala Val Arg
        35          


<210> 266
<211> 9
<212> PRT
<213> Mus musculus

<400> 266
Leu Asn Gln Trp Cys Asn Val Val Arg
 1               5                  


<210> 267
<211> 13
<212> PRT
<213> Mus musculus

<400> 267
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
 1               5                  10              


<210> 268
<211> 19
<212> PRT
<213> Mus musculus

<400> 268
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu
 1               5                  10                  15      
Ala Ala Asp
            


<210> 269
<211> 11
<212> PRT
<213> Mus musculus

<400> 269
Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg
 1               5                  10      


<210> 270
<211> 12
<212> PRT
<213> Mus musculus

<400> 270
Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val Arg
 1               5                  10          


<210> 271
<211> 8
<212> PRT
<213> Mus musculus

<400> 271
Gly Arg Lys Thr Glu Lys Glu Lys
 1               5              


<210> 272
<211> 35
<212> PRT
<213> Mus musculus

<400> 272
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
 1               5                  10                  15      
Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn
            20                  25                  30          
Phe Ser Lys
        35  


<210> 273
<211> 15
<212> PRT
<213> Mus musculus

<400> 273
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys
 1               5                  10                  15  


<210> 274
<211> 13
<212> PRT
<213> Mus musculus

<400> 274
Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg
 1               5                  10              


<210> 275
<211> 20
<212> PRT
<213> Mus musculus

<400> 275
Thr Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val
 1               5                  10                  15      
Leu Pro Pro Arg
            20  


<210> 276
<211> 22
<212> PRT
<213> Mus musculus

<400> 276
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
 1               5                  10                  15      
Leu Ser Glu Glu Asp Arg
            20          


<210> 277
<211> 55
<212> PRT
<213> Mus musculus

<400> 277
Glu Ala Leu Met Ala Lys Cys Asn Glu Tyr Arg Arg Arg Leu Leu Gly
 1               5                  10                  15      
Ala Asn Ile Arg Val Arg Val Asp Leu Arg Asp Asn Tyr Ser Pro Gly
            20                  25                  30          
Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro Val Arg Leu Glu
        35                  40                  45              
Val Gly Pro Arg Asp Met Lys
    50                  55  


<210> 278
<211> 8
<212> PRT
<213> Mus musculus

<400> 278
Ser Cys Gln Phe Val Ala Val Arg
 1               5              


<210> 279
<211> 20
<212> PRT
<213> Mus musculus

<400> 279
Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu Lys Glu Ala Glu Ala
 1               5                  10                  15      
Lys Leu Glu Lys
            20  


<210> 280
<211> 12
<212> PRT
<213> Mus musculus

<400> 280
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 281
<211> 6
<212> PRT
<213> Mus musculus

<400> 281
Ala Ser Glu Asp Leu Lys
 1               5      


<210> 282
<211> 14
<212> PRT
<213> Mus musculus

<400> 282
Thr His Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys
 1               5                  10                  


<210> 283
<211> 6
<212> PRT
<213> Mus musculus

<400> 283
Val Leu Asp Ala Gly Lys
 1               5      


<210> 284
<211> 18
<212> PRT
<213> Mus musculus

<400> 284
Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
 1               5                  10                  15      
Lys Lys
        


<210> 285
<211> 615
<212> PRT
<213> Mus musculus

<400> 285
Ser Asn Pro Val Ser Asn Ala Gln Pro Ala Gly Ala Glu Lys Pro Glu
 1               5                  10                  15      
Ala Lys Val Leu Phe Asp Arg Val Ala Cys Gln Gly Glu Val Val Arg
            20                  25                  30          
Lys Leu Lys Ala Glu Lys Ala Ser Lys Asp Gln Val Asp Ser Ala Val
        35                  40                  45              
Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Thr Gly Ile
    50                  55                  60                  
Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys
65                  70                  75                  80  
Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys
                85                  90                  95      
Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys Ser Gln Gly Ser Gly
            100                 105                 110         
Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr
        115                 120                 125             
Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Glu Trp Tyr
    130                 135                 140                 
Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser
145                 150                 155                 160 
Gly Cys Tyr Ile Leu Arg Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile
                165                 170                 175     
Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys
            180                 185                 190         
Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala Leu Glu Lys Glu Lys Asn
        195                 200                 205             
His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly
    210                 215                 220                 
Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr
225                 230                 235                 240 
Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu
                245                 250                 255     
Ala Val Arg Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys
            260                 265                 270         
His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly
        275                 280                 285             
His Ser Ala Phe Ala Thr Phe Glu Glu Ala Ala Asp Glu Val Leu Gln
    290                 295                 300                 
Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu Leu Leu Ala Ile Pro
305                 310                 315                 320 
Val Val Arg Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp
                325                 330                 335     
Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile
            340                 345                 350         
Gln Gly Ala Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Cys
        355                 360                 365             
Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln Phe Ala
    370                 375                 380                 
Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Val
385                 390                 395                 400 
Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala
                405                 410                 415     
Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser
            420                 425                 430         
Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys Asn Glu Tyr Arg Arg
        435                 440                 445             
Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val Asp Leu Arg Asp Asn
    450                 455                 460                 
Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro
465                 470                 475                 480 
Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val
                485                 490                 495     
Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu Lys Glu
            500                 505                 510         
Ala Glu Ala Lys Leu Glu Lys Val Leu Glu Asp Ile Gln Leu Asn Leu
        515                 520                 525             
Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ser Asn
    530                 535                 540                 
Thr Leu Glu Asp Phe Gln Lys Val Leu Asp Ala Gly Lys Val Ala Gln
545                 550                 555                 560 
Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Met
                565                 570                 575     
Thr Ala Arg Asp Gln Asp Val Glu Pro Gly Ala Pro Ser Met Gly Ala
            580                 585                 590         
Lys Ser Leu Cys Ile Pro Phe Asn Pro Leu Cys Glu Leu Gln Pro Gly
        595                 600                 605             
Ala Met Cys Val Cys Gly Lys
    610                 615 


<210> 286
<211> 577
<212> PRT
<213> Mus musculus

<400> 286
Ser His Ser Asn Pro Val Ser Asn Ala Gln Pro Ala Gly Ala Glu Lys
 1               5                  10                  15      
Pro Glu Ala Lys Val Leu Phe Asp Arg Val Ala Cys Gln Gly Glu Val
            20                  25                  30          
Val Arg Lys Leu Lys Ala Glu Lys Ala Ser Lys Asp Gln Val Asp Ser
        35                  40                  45              
Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Thr
    50                  55                  60                  
Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp
65                  70                  75                  80  
Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro
                85                  90                  95      
Gln Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys Ser Gln Gly
            100                 105                 110         
Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys
        115                 120                 125             
Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Glu
    130                 135                 140                 
Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr Tyr Asp
145                 150                 155                 160 
Val Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ser Tyr Ser Ile Trp Glu
                165                 170                 175     
Ser Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu
            180                 185                 190         
Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala Leu Glu Lys Glu
        195                 200                 205             
Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg
    210                 215                 220                 
Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser
225                 230                 235                 240 
Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg
                245                 250                 255     
Asp Leu Ala Val Arg Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu
            260                 265                 270         
Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln
        275                 280                 285             
Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu Ala Ala Asp Glu Val
    290                 295                 300                 
Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu Leu Leu Ala
305                 310                 315                 320 
Ile Pro Val Val Arg Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly
                325                 330                 335     
Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg
            340                 345                 350         
Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn Phe Ser Lys
        355                 360                 365             
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln
    370                 375                 380                 
Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val
385                 390                 395                 400 
Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg
                405                 410                 415     
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
            420                 425                 430         
Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys Asn Glu Tyr
        435                 440                 445             
Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val Asp Leu Arg
    450                 455                 460                 
Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly
465                 470                 475                 480 
Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln
                485                 490                 495     
Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu
            500                 505                 510         
Lys Glu Ala Glu Ala Lys Leu Glu Lys Val Leu Glu Asp Ile Gln Leu
        515                 520                 525             
Asn Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val
    530                 535                 540                 
Ser Asn Thr Leu Glu Asp Phe Gln Lys Val Leu Asp Ala Gly Lys Val
545                 550                 555                 560 
Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys
                565                 570                 575     
Lys
    


<210> 287
<211> 18
<212> PRT
<213> Mus musculus

<400> 287
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 288
<211> 10
<212> PRT
<213> Mus musculus

<400> 288
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 289
<211> 15
<212> PRT
<213> Mus musculus

<400> 289
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 290
<211> 36
<212> PRT
<213> Mus musculus

<400> 290
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 291
<211> 19
<212> PRT
<213> Mus musculus

<400> 291
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 292
<211> 15
<212> PRT
<213> Mus musculus

<400> 292
Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg
 1               5                  10                  15  


<210> 293
<211> 14
<212> PRT
<213> Mus musculus

<400> 293
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu
 1               5                  10                  


<210> 294
<211> 9
<212> PRT
<213> Mus musculus

<400> 294
Thr Val Met Tyr Pro Ala Tyr Ala Lys
 1               5                  


<210> 295
<211> 11
<212> PRT
<213> Mus musculus

<400> 295
Trp Val Gln Ser His Arg Asp Leu Ala Val Arg
 1               5                  10      


<210> 296
<211> 9
<212> PRT
<213> Mus musculus

<400> 296
Leu Asn Gln Trp Cys Asn Val Val Arg
 1               5                  


<210> 297
<211> 13
<212> PRT
<213> Mus musculus

<400> 297
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
 1               5                  10              


<210> 298
<211> 22
<212> PRT
<213> Mus musculus

<400> 298
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu
 1               5                  10                  15      
Ala Ala Asp Glu Val Leu
            20          


<210> 299
<211> 20
<212> PRT
<213> Mus musculus

<400> 299
Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu Leu Leu Ala Ile
 1               5                  10                  15      
Pro Val Val Arg
            20  


<210> 300
<211> 6
<212> PRT
<213> Mus musculus

<400> 300
Gly Arg Lys Thr Glu Lys
 1               5      


<210> 301
<211> 37
<212> PRT
<213> Mus musculus

<400> 301
Glu Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile
 1               5                  10                  15      
Ser Ala Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly
            20                  25                  30          
Gln Asn Phe Ser Lys
        35          


<210> 302
<211> 10
<212> PRT
<213> Mus musculus

<400> 302
Met Cys Glu Ile Val Phe Glu Asp Pro Lys
 1               5                  10  


<210> 303
<211> 5
<212> PRT
<213> Mus musculus

<400> 303
Thr Pro Gly Glu Lys
 1               5  


<210> 304
<211> 13
<212> PRT
<213> Mus musculus

<400> 304
Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg
 1               5                  10              


<210> 305
<211> 20
<212> PRT
<213> Mus musculus

<400> 305
Thr Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val
 1               5                  10                  15      
Leu Pro Pro Arg
            20  


<210> 306
<211> 22
<212> PRT
<213> Mus musculus

<400> 306
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
 1               5                  10                  15      
Leu Ser Glu Glu Asp Arg
            20          


<210> 307
<211> 55
<212> PRT
<213> Mus musculus

<400> 307
Glu Ala Leu Met Ala Lys Cys Asn Glu Tyr Arg Arg Arg Leu Leu Gly
 1               5                  10                  15      
Ala Asn Ile Arg Val Arg Val Asp Leu Arg Asp Asn Tyr Ser Pro Gly
            20                  25                  30          
Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro Val Arg Leu Glu
        35                  40                  45              
Val Gly Pro Arg Asp Met Lys
    50                  55  


<210> 308
<211> 8
<212> PRT
<213> Mus musculus

<400> 308
Ser Cys Gln Phe Val Ala Val Arg
 1               5              


<210> 309
<211> 20
<212> PRT
<213> Mus musculus

<400> 309
Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu Lys Glu Ala Glu Ala
 1               5                  10                  15      
Lys Leu Glu Lys
            20  


<210> 310
<211> 12
<212> PRT
<213> Mus musculus

<400> 310
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 311
<211> 6
<212> PRT
<213> Mus musculus

<400> 311
Ala Ser Glu Asp Leu Lys
 1               5      


<210> 312
<211> 14
<212> PRT
<213> Mus musculus

<400> 312
Thr His Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys
 1               5                  10                  


<210> 313
<211> 6
<212> PRT
<213> Mus musculus

<400> 313
Val Leu Asp Ala Gly Lys
 1               5      


<210> 314
<211> 18
<212> PRT
<213> Mus musculus

<400> 314
Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
 1               5                  10                  15      
Lys Lys
        


<210> 315
<211> 4
<212> PRT
<213> Mus musculus

<400> 315
Met Thr Ala Arg
 1              


<210> 316
<211> 36
<212> PRT
<213> Mus musculus

<400> 316
Asp Gln Asp Val Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu
 1               5                  10                  15      
Cys Ile Pro Phe Asn Pro Leu Cys Glu Leu Gln Pro Gly Ala Met Cys
            20                  25                  30          
Val Cys Gly Lys
        35      


<210> 317
<211> 18
<212> PRT
<213> Mus musculus

<400> 317
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 318
<211> 10
<212> PRT
<213> Mus musculus

<400> 318
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 319
<211> 15
<212> PRT
<213> Mus musculus

<400> 319
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 320
<211> 36
<212> PRT
<213> Mus musculus

<400> 320
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 321
<211> 19
<212> PRT
<213> Mus musculus

<400> 321
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 322
<211> 17
<212> PRT
<213> Mus musculus

<400> 322
Glu Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr
 1               5                  10                  15      
Arg
    


<210> 323
<211> 23
<212> PRT
<213> Mus musculus

<400> 323
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val
 1               5                  10                  15      
Met Tyr Pro Ala Tyr Ala Lys
            20              


<210> 324
<211> 11
<212> PRT
<213> Mus musculus

<400> 324
Trp Val Gln Ser His Arg Asp Leu Ala Val Arg
 1               5                  10      


<210> 325
<211> 9
<212> PRT
<213> Mus musculus

<400> 325
Leu Asn Gln Trp Cys Asn Val Val Arg
 1               5                  


<210> 326
<211> 13
<212> PRT
<213> Mus musculus

<400> 326
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
 1               5                  10              


<210> 327
<211> 19
<212> PRT
<213> Mus musculus

<400> 327
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu
 1               5                  10                  15      
Ala Ala Asp
            


<210> 328
<211> 23
<212> PRT
<213> Mus musculus

<400> 328
Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu Leu
 1               5                  10                  15      
Leu Ala Ile Pro Val Val Arg
            20              


<210> 329
<211> 8
<212> PRT
<213> Mus musculus

<400> 329
Gly Arg Lys Thr Glu Lys Glu Lys
 1               5              


<210> 330
<211> 19
<212> PRT
<213> Mus musculus

<400> 330
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
 1               5                  10                  15      
Ser Gly Arg
            


<210> 331
<211> 16
<212> PRT
<213> Mus musculus

<400> 331
Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn Phe Ser Lys
 1               5                  10                  15      


<210> 332
<211> 76
<212> PRT
<213> Mus musculus

<400> 332
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln
 1               5                  10                  15      
Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val
            20                  25                  30          
Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg
        35                  40                  45              
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
    50                  55                  60                  
Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys
65                  70                  75      


<210> 333
<211> 49
<212> PRT
<213> Mus musculus

<400> 333
Cys Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg
 1               5                  10                  15      
Val Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp
            20                  25                  30          
Glu Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met
        35                  40                  45              
Lys
    


<210> 334
<211> 8
<212> PRT
<213> Mus musculus

<400> 334
Ser Cys Gln Phe Val Ala Val Arg
 1               5              


<210> 335
<211> 20
<212> PRT
<213> Mus musculus

<400> 335
Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu Lys Glu Ala Glu Ala
 1               5                  10                  15      
Lys Leu Glu Lys
            20  


<210> 336
<211> 12
<212> PRT
<213> Mus musculus

<400> 336
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 337
<211> 6
<212> PRT
<213> Mus musculus

<400> 337
Ala Ser Glu Asp Leu Lys
 1               5      


<210> 338
<211> 14
<212> PRT
<213> Mus musculus

<400> 338
Thr His Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys
 1               5                  10                  


<210> 339
<211> 6
<212> PRT
<213> Mus musculus

<400> 339
Val Leu Asp Ala Gly Lys
 1               5      


<210> 340
<211> 18
<212> PRT
<213> Mus musculus

<400> 340
Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
 1               5                  10                  15      
Lys Lys
        


<210> 341
<211> 4
<212> PRT
<213> Mus musculus

<400> 341
Met Thr Ala Arg
 1              


<210> 342
<211> 36
<212> PRT
<213> Mus musculus

<400> 342
Asp Gln Asp Val Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu
 1               5                  10                  15      
Cys Ile Pro Phe Asn Pro Leu Cys Glu Leu Gln Pro Gly Ala Met Cys
            20                  25                  30          
Val Cys Gly Lys
        35      


<210> 343
<211> 508
<212> PRT
<213> Mus musculus

<400> 343
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn
            20                  25                  30          
Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu
        35                  40                  45              
Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ser Tyr Ser
    50                  55                  60                  
Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu
65                  70                  75                  80  
Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala Leu
                85                  90                  95      
Glu Lys Glu Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp
            100                 105                 110         
Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg
        115                 120                 125             
Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln
    130                 135                 140                 
Ser His Arg Asp Leu Ala Val Arg Leu Asn Gln Trp Cys Asn Val Val
145                 150                 155                 160 
Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe
                165                 170                 175     
Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu Ala Ala
            180                 185                 190         
Asp Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu
        195                 200                 205             
Leu Leu Ala Ile Pro Val Val Arg Gly Arg Lys Thr Glu Lys Glu Lys
    210                 215                 220                 
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
225                 230                 235                 240 
Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn
                245                 250                 255     
Phe Ser Lys Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly
            260                 265                 270         
Glu Lys Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr
        275                 280                 285             
Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu
    290                 295                 300                 
Pro Pro Arg Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile
305                 310                 315                 320 
Thr Asn Ala Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys
                325                 330                 335     
Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val
            340                 345                 350         
Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu
        355                 360                 365             
Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys
    370                 375                 380                 
Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr
385                 390                 395                 400 
Ile Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys Val Leu Glu Asp
                405                 410                 415     
Ile Gln Leu Asn Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His
            420                 425                 430         
Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys Val Leu Asp Ala
        435                 440                 445             
Gly Lys Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp
    450                 455                 460                 
Trp Ile Lys Lys Met Thr Ala Arg Asp Gln Asp Val Glu Pro Gly Ala
465                 470                 475                 480 
Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Asn Pro Leu Cys
                485                 490                 495     
Glu Leu Gln Pro Gly Ala Met Cys Val Cys Gly Lys
            500                 505             


<210> 344
<211> 508
<212> PRT
<213> Mus musculus

<400> 344
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn
            20                  25                  30          
Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu
        35                  40                  45              
Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ser Tyr Ser
    50                  55                  60                  
Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu
65                  70                  75                  80  
Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala Leu
                85                  90                  95      
Glu Lys Glu Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp
            100                 105                 110         
Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg
        115                 120                 125             
Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln
    130                 135                 140                 
Ser His Arg Asp Leu Ala Val Arg Leu Asn Gln Trp Cys Asn Val Val
145                 150                 155                 160 
Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe
                165                 170                 175     
Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu Ala Ala
            180                 185                 190         
Asp Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu
        195                 200                 205             
Leu Leu Ala Ile Pro Val Val Arg Gly Arg Lys Thr Glu Lys Glu Lys
    210                 215                 220                 
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
225                 230                 235                 240 
Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn
                245                 250                 255     
Phe Ser Lys Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly
            260                 265                 270         
Glu Lys Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr
        275                 280                 285             
Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu
    290                 295                 300                 
Pro Pro Arg Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile
305                 310                 315                 320 
Thr Asn Ala Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys
                325                 330                 335     
Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val
            340                 345                 350         
Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu
        355                 360                 365             
Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys
    370                 375                 380                 
Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr
385                 390                 395                 400 
Ile Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys Val Leu Glu Asp
                405                 410                 415     
Ile Gln Leu Asn Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His
            420                 425                 430         
Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys Val Leu Asp Ala
        435                 440                 445             
Gly Lys Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp
    450                 455                 460                 
Trp Ile Lys Lys Met Thr Ala Arg Asp Gln Asp Val Glu Pro Gly Ala
465                 470                 475                 480 
Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Asn Pro Leu Cys
                485                 490                 495     
Glu Leu Gln Pro Gly Ala Met Cys Val Cys Gly Lys
            500                 505             


<210> 345
<211> 20
<212> PRT
<213> Mus musculus

<400> 345
Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu
 1               5                  10                  15      
Asp Lys Asp Lys
            20  


<210> 346
<211> 28
<212> PRT
<213> Mus musculus

<400> 346
Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln
 1               5                  10                  15      
Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys
            20                  25              


<210> 347
<211> 18
<212> PRT
<213> Mus musculus

<400> 347
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 348
<211> 10
<212> PRT
<213> Mus musculus

<400> 348
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 349
<211> 15
<212> PRT
<213> Mus musculus

<400> 349
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 350
<211> 36
<212> PRT
<213> Mus musculus

<400> 350
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 351
<211> 19
<212> PRT
<213> Mus musculus

<400> 351
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 352
<211> 17
<212> PRT
<213> Mus musculus

<400> 352
Glu Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp Val Thr
 1               5                  10                  15      
Arg
    


<210> 353
<211> 23
<212> PRT
<213> Mus musculus

<400> 353
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val
 1               5                  10                  15      
Met Tyr Pro Ala Tyr Ala Lys
            20              


<210> 354
<211> 11
<212> PRT
<213> Mus musculus

<400> 354
Trp Val Gln Ser His Arg Asp Leu Ala Val Arg
 1               5                  10      


<210> 355
<211> 9
<212> PRT
<213> Mus musculus

<400> 355
Leu Asn Gln Trp Cys Asn Val Val Arg
 1               5                  


<210> 356
<211> 13
<212> PRT
<213> Mus musculus

<400> 356
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg
 1               5                  10              


<210> 357
<211> 42
<212> PRT
<213> Mus musculus

<400> 357
Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu
 1               5                  10                  15      
Ala Ala Asp Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr
            20                  25                  30          
Glu Glu Leu Leu Ala Ile Pro Val Val Arg
        35                  40          


<210> 358
<211> 8
<212> PRT
<213> Mus musculus

<400> 358
Gly Arg Lys Thr Glu Lys Glu Lys
 1               5              


<210> 359
<211> 19
<212> PRT
<213> Mus musculus

<400> 359
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
 1               5                  10                  15      
Ser Gly Arg
            


<210> 360
<211> 44
<212> PRT
<213> Mus musculus

<400> 360
Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn Phe Ser Lys
 1               5                  10                  15      
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln
            20                  25                  30          
Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg
        35                  40                  


<210> 361
<211> 20
<212> PRT
<213> Mus musculus

<400> 361
Thr Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val
 1               5                  10                  15      
Leu Pro Pro Arg
            20  


<210> 362
<211> 28
<212> PRT
<213> Mus musculus

<400> 362
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
 1               5                  10                  15      
Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys
            20                  25              


<210> 363
<211> 77
<212> PRT
<213> Mus musculus

<400> 363
Cys Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg
 1               5                  10                  15      
Val Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp
            20                  25                  30          
Glu Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met
        35                  40                  45              
Lys Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu
    50                  55                  60                  
Thr Ile Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys
65                  70                  75          


<210> 364
<211> 12
<212> PRT
<213> Mus musculus

<400> 364
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 365
<211> 6
<212> PRT
<213> Mus musculus

<400> 365
Ala Ser Glu Asp Leu Lys
 1               5      


<210> 366
<211> 14
<212> PRT
<213> Mus musculus

<400> 366
Thr His Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys
 1               5                  10                  


<210> 367
<211> 6
<212> PRT
<213> Mus musculus

<400> 367
Val Leu Asp Ala Gly Lys
 1               5      


<210> 368
<211> 18
<212> PRT
<213> Mus musculus

<400> 368
Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
 1               5                  10                  15      
Lys Lys
        


<210> 369
<211> 4
<212> PRT
<213> Mus musculus

<400> 369
Met Thr Ala Arg
 1              


<210> 370
<211> 36
<212> PRT
<213> Mus musculus

<400> 370
Asp Gln Asp Val Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu
 1               5                  10                  15      
Cys Ile Pro Phe Asn Pro Leu Cys Glu Leu Gln Pro Gly Ala Met Cys
            20                  25                  30          
Val Cys Gly Lys
        35      


<210> 371
<211> 4
<212> PRT
<213> Mus musculus

<400> 371
Asn Pro Ala Lys
 1              


<210> 372
<211> 7
<212> PRT
<213> Mus musculus

<400> 372
Phe Tyr Thr Leu Phe Gly Arg
 1               5          


<210> 373
<211> 567
<212> PRT
<213> Mus musculus

<400> 373
Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu
 1               5                  10                  15      
Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln
            20                  25                  30          
Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser Ser Lys
        35                  40                  45              
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
    50                  55                  60                  
Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn
65                  70                  75                  80  
Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu
                85                  90                  95      
Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ser Tyr Ser
            100                 105                 110         
Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu
        115                 120                 125             
Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala Leu
    130                 135                 140                 
Glu Lys Glu Lys Asn His Ile Glu Asp Phe Ala Pro Glu Val Ala Trp
145                 150                 155                 160 
Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg
                165                 170                 175     
Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln
            180                 185                 190         
Ser His Arg Asp Leu Ala Val Arg Leu Asn Gln Trp Cys Asn Val Val
        195                 200                 205             
Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe
    210                 215                 220                 
Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Phe Glu Glu Ala Ala
225                 230                 235                 240 
Asp Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu
                245                 250                 255     
Leu Leu Ala Ile Pro Val Val Arg Gly Arg Lys Thr Glu Lys Glu Lys
            260                 265                 270         
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
        275                 280                 285             
Ser Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn
    290                 295                 300                 
Phe Ser Lys Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly
305                 310                 315                 320 
Glu Lys Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr
                325                 330                 335     
Ile Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu
            340                 345                 350         
Pro Pro Arg Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile
        355                 360                 365             
Thr Asn Ala Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys
    370                 375                 380                 
Asn Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val
385                 390                 395                 400 
Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu
                405                 410                 415     
Leu Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys
            420                 425                 430         
Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr
        435                 440                 445             
Ile Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys Val Leu Glu Asp
    450                 455                 460                 
Ile Gln Leu Asn Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His
465                 470                 475                 480 
Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys Val Leu Asp Ala
                485                 490                 495     
Gly Lys Val Ala Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp
            500                 505                 510         
Trp Ile Lys Lys Met Thr Ala Arg Asp Gln Asp Val Glu Pro Gly Ala
        515                 520                 525             
Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Asn Pro Leu Cys
    530                 535                 540                 
Glu Leu Gln Pro Gly Ala Met Cys Val Cys Gly Lys Asn Pro Ala Lys
545                 550                 555                 560 
Phe Tyr Thr Leu Phe Gly Arg
                565         


<210> 374
<211> 11
<212> PRT
<213> Mus musculus

<400> 374
Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg
 1               5                  10      


<210> 375
<211> 20
<212> PRT
<213> Mus musculus

<400> 375
Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val Arg Gly Arg Lys Thr
 1               5                  10                  15      
Glu Lys Glu Lys
            20  


<210> 376
<211> 19
<212> PRT
<213> Mus musculus

<400> 376
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
 1               5                  10                  15      
Ser Gly Arg
            


<210> 377
<211> 16
<212> PRT
<213> Mus musculus

<400> 377
Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn Phe Ser Lys
 1               5                  10                  15      


<210> 378
<211> 153
<212> PRT
<213> Mus musculus

<400> 378
Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu Lys Gln
 1               5                  10                  15      
Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val
            20                  25                  30          
Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg
        35                  40                  45              
Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr Asn Ala
    50                  55                  60                  
Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys Asn Glu Tyr
65                  70                  75                  80  
Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val Asp Leu Arg
                85                  90                  95      
Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly
            100                 105                 110         
Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln
        115                 120                 125             
Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Ile Ala Glu
    130                 135                 140                 
Lys Glu Ala Glu Ala Lys Leu Glu Lys
145                 150             


<210> 379
<211> 12
<212> PRT
<213> Mus musculus

<400> 379
Val Leu Glu Asp Ile Gln Leu Asn Leu Phe Thr Arg
 1               5                  10          


<210> 380
<211> 6
<212> PRT
<213> Mus musculus

<400> 380
Ala Ser Glu Asp Leu Lys
 1               5      


<210> 381
<211> 14
<212> PRT
<213> Mus musculus

<400> 381
Thr His Met Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys
 1               5                  10                  


<210> 382
<211> 251
<212> PRT
<213> Mus musculus

<400> 382
Glu Val Leu Gln Ile Leu Glu Leu Tyr Ala Arg Val Tyr Glu Glu Leu
 1               5                  10                  15      
Leu Ala Ile Pro Val Val Arg Gly Arg Lys Thr Glu Lys Glu Lys Phe
            20                  25                  30          
Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser
        35                  40                  45              
Gly Arg Ala Ile Gln Gly Ala Thr Ser His His Leu Gly Gln Asn Phe
    50                  55                  60                  
Ser Lys Met Cys Glu Ile Val Phe Glu Asp Pro Lys Thr Pro Gly Glu
65                  70                  75                  80  
Lys Gln Phe Ala Tyr Gln Cys Ser Trp Gly Leu Thr Thr Arg Thr Ile
                85                  90                  95      
Gly Val Met Val Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro
            100                 105                 110         
Pro Arg Val Ala Ser Val Gln Val Val Val Ile Pro Cys Gly Ile Thr
        115                 120                 125             
Asn Ala Leu Ser Glu Glu Asp Arg Glu Ala Leu Met Ala Lys Cys Asn
    130                 135                 140                 
Glu Tyr Arg Arg Arg Leu Leu Gly Ala Asn Ile Arg Val Arg Val Asp
145                 150                 155                 160 
Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu
                165                 170                 175     
Lys Gly Val Pro Val Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser
            180                 185                 190         
Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Ile
        195                 200                 205             
Ala Glu Lys Glu Ala Glu Ala Lys Leu Glu Lys Val Leu Glu Asp Ile
    210                 215                 220                 
Gln Leu Asn Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met
225                 230                 235                 240 
Val Val Ser Asn Thr Leu Glu Asp Phe Gln Lys
                245                 250     


<210> 383
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 383
Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His Phe
 1               5                  10                  15      
Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys Ala
            20                  25                  30          
Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu Gln
        35                  40                  45              
Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu Gln
    50                  55                  60                  
Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys Cys
65                  70                  75                  80  
Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg Asp
                85                  90                  95      
Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly Asn
            100                 105                 110         
Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val Asp
        115                 120                 125             
Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His Asp
    130                 135                 140                 
Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg Lys
145                 150                 155                 160 
Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val Leu
                165                 170                 175     
Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp Gly
            180                 185                 190         
Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg Gly
        195                 200                 205             
Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser Ser
    210                 215                 220                 
Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn Lys
225                 230                 235                 240 
Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys Lys
                245                 250                 255     
Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys Glu
            260                 265                 270         
Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val Trp
        275                 280                 285             
Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe Ser
    290                 295                 300                 
Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile Thr
305                 310                 315                 320 
Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala Lys
                325                 330                 335     
Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr Trp
            340                 345                 350         
Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val Thr
        355                 360                 365             
Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp Phe
    370                 375                 380                 
Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu Gly
385                 390                 395                 400 
Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu Gln
                405                 410                 415     
Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser Pro
            420                 425                 430         
Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp Gly
        435                 440                 445             
His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys Val
    450                 455                 460                 
Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro Thr
465                 470                 475                 480 
Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val Leu
                485                 490                 495     
Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys Ala
            500                 505                 510         
Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu Leu
        515                 520                 525             
Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys Pro
    530                 535                 540                 
Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser Ser
545                 550                 555                 560 
Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala Gln
                565                 570                 575     
Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala Lys
            580                 585                 590         
Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr Lys
        595                 600                 605             
Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser Gln
    610                 615                 620                 
Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu Glu
625                 630                 635                 640 
Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu
                645                 650                 655     
Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp
            660                 665                 670         
Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu
        675                 680                 685             
Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys
    690                 695                 700                 
Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys
705                 710                 715                 720 
Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln
                725                 730                 735     
Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys
            740                 745                 750         
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala
        755                 760                 765             
Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His
    770                 775                 780                 
Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp
785                 790                 795                 800 
Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val
                805                 810                 815     
Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys
            820                 825                 830         
Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr
        835                 840                 845             
Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr
    850                 855                 860                 
Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His
865                 870                 875                 880 
Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp
                885                 890                 895     
Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp
            900                 905                 910         
Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu
        915                 920                 925             
Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu
    930                 935                 940                 
Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala
945                 950                 955                 960 
Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly
                965                 970                 975     
Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser
            980                 985                 990         
Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys
        995                 1000                1005            
Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly
    1010                1015                1020                
Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro
1025                1030                1035               1040 
Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn
                1045                1050                1055    
Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp
            1060                1065                1070        
Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu
        1075                1080                1085            
Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys
    1090                1095                1100                
Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys
1105                1110                1115               1120 
Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala
                1125                1130                1135    
Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln
            1140                1145                1150        
Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val
        1155                1160                1165            
Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys
    1170                1175                1180                
Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
1185                1190                1195               1200 
Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser
                1205                1210                1215    
Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu
            1220                1225                1230        
Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr
        1235                1240                1245            
Thr Leu Phe Gly Arg Ser Tyr
    1250                1255


<210> 384
<211> 3768
<212> DNA
<213> Homo sapiens

<400> 384
atgttgcata tcaaaccaga tcaatttact tatacttcgg atcattttga aactataatg 60
aagtatgcag agaagctaat tcaagaaggg aaggcttatg tggatgatac tcctgctgaa 120
cagatgaaag cagaacgtga gcagaggata gactctaaac atagaaaaaa ccctattgag 180
aagaatctac aaatgtggga agaaatgaaa aaagggagcc agtttggtca gtcctgttgt 240
ttgcgagcaa aaattgacat gagtagtaac aatggatgca tgagagatcc aaccctttat 300
cgctgcaaaa ttcaaccaca tccaagaact ggaaataaat acaatgttta tccaacatat 360
gattttgcct gccccatagt tgacagcatc gaaggtgtta cacatgccct gagaacaaca 420
gaataccatg acagagatga gcagttttac tggattattg aagctttagg cataagaaaa 480
ccatatattt gggaatatag tcggctaaat ctcaacaaca cagtgctatc caaaagaaaa 540
ctcacatggt ttgtcaatga aggactagta gatggatggg atgacccaag atttcctacg 600
gttcgtggtg tactgagaag agggatgaca gttgaaggac tgaaacagtt tattgctgct 660
cagggctcct cacgttcagt cgtgaacatg gagtgggaca aaatctgggc gtttaacaaa 720
aaggttattg acccagtggc tccacgatat gttgcattac tgaagaaaga agtgatccca 780
gtgaatgtac ctgaagctca ggaggagatg aaagaagtag ccaaacaccc aaagaatcct 840
gaggttggct tgaagcctgt gtggtatagt cccaaagttt tcattgaagg tgctgatgca 900
gagacttttt cggagggtga gatggttaca tttataaatt ggggcaacct caacattaca 960
aaaatacaca aaaatgcaga tggaaaaatc atatctcttg atgcaaagtt gaatttggaa 1020
aacaaagact acaagaaaac cactaaggtc acttggcttg cagagactac acatgctctt 1080
cctattccag taatctgtgt cacttatgag cacttgatca caaagccagt gctaggaaaa 1140
gacgaggact ttaagcagta tgtcaacaag aacagtaagc atgaagagct aatgctaggg 1200
gatccctgcc ttaaggattt gaaaaaagga gatattatac aactccagag aagaggattc 1260
ttcatatgtg atcaacctta tgaacctgtt agcccatata gttgcaagga agccccgtgt 1320
gttttgatat acattcctga tgggcacaca aaggaaatgc caacatcagg gtcaaaggaa 1380
aagaccaaag tagaagccac aaaaaatgag acctctgctc cttttaagga aagaccaaca 1440
ccttctctga ataataattg tactacatct gaggattcct tggtccttta caatagagtg 1500
gctgttcaag gagatgtggt tcgtgaatta aaagccaaga aagcaccaaa ggaagatgta 1560
gatgcagctg taaaacagct tttgtctttg aaagctgaat ataaggagaa aactggccag 1620
gaatataaac ctggaaaccc tcctgctgaa ataggacaga atatttcttc taattcctca 1680
gcaagtattc tggaaagtaa atctctgtat gatgaagttg ctgcacaagg ggaggtggtt 1740
cgtaagctaa aagctgaaaa atcccctaag gctaaaataa atgaagctgt agaatgctta 1800
ctgtccctga aggctcagta taaagaaaaa actgggaagg agtacatacc tggtcagccc 1860
ccattatctc aaagttcgga ttcaagccca accagaaatt ctgaacctgc tggtttagaa 1920
acaccagaag cgaaagtact ttttgacaaa gtagcttctc aaggggaagt agttcggaaa 1980
cttaaaactg aaaaagcccc taaggatcaa gtagatatag ctgttcaaga actccttcag 2040
ctaaaggcac agtacaagtc tttgatagga gtagagtata agcctgtgtc ggccactgga 2100
gctgaggaca aagataagaa gaagaaagaa aaagaaaata aatctgaaaa gcagaataag 2160
cctcagaaac aaaatgatgg ccaaaggaaa gacccttcta aaaaccaagg aggtgggctc 2220
tcatcaagtg gagcaggaga agggcagggg cctaagaaac agaccaggtt gggtcttgag 2280
gcaaaaaaag aagaaaatct tgctgattgg tattctcagg tcatcacaaa gtcagaaatg 2340
attgaatacc atgacataag tggctgttat attcttcgtc cctgggccta tgccatttgg 2400
gaagccatca aggacttttt tgatgctgag atcaagaaac ttggtgttga aaactgctac 2460
ttccccatgt ttgtgtctca aagtgcatta gagaaagaga agactcatgt tgctgacttt 2520
gccccagagg ttgcttgggt tacaagatct ggcaaaaccg agctggcaga accaattgcc 2580
attcgtccta ctagtgaaac agtaatgtat cctgcatatg caaaatgggt acagtcacac 2640
agagacctgc ccatcaagct caatcagtgg tgcaatgtgg tgcgttggga attcaagcat 2700
cctcagcctt tcctacgtac tcgtgaattt ctttggcagg aagggcacag tgcttttgct 2760
accatggaag aggcagcgga agaggtcttg cagatacttg acttatatgc tcaggtatat 2820
gaagaactcc tggcaattcc tgttgttaaa ggaagaaaga cggaaaagga aaaatttgca 2880
ggaggagact atacaactac aatagaagca tttatatctg ctagtggaag agctatccag 2940
ggaggaacat cacatcattt agggcagaat ttttccaaaa tgtttgaaat cgtttttgaa 3000
gatccaaaga taccaggaga gaagcaattt gcctatcaaa actcctgggg cctgacaact 3060
cgaactattg gtgttatgac catggttcat ggggacaaca tgggtttagt attaccaccc 3120
cgtgtagcat gtgttcaggt ggtgattatt ccttgtggca ttaccaatgc actttctgaa 3180
gaagacaaag aagcgctgat tgcaaaatgc aatgattatc gaaggcgatt actcagtgtt 3240
aacatccgcg ttagagctga tttacgagat aattattctc caggttggaa attcaatcac 3300
tgggagctca agggagttcc cattagactt gaagttgggc cacgtgatat gaagagctgt 3360
cagtttgtag ccgtcagacg agatactgga gaaaagctga cagttgctga aaatgaggca 3420
gagactaaac ttcaagctat tttggaagac atccaggtca cccttttcac aagggcttct 3480
gaagacctta agactcatat ggttgtggct aatacaatgg aagactttca gaagatacta 3540
gattctggaa agattgttca gattccattc tgtggggaaa ttgactgtga ggactggatc 3600
aaaaagacca ctgccaggga tcaagatctt gaacctggtg ctccatccat gggagctaaa 3660
agcctttgca tccccttcaa accactctgt gaactgcagc ctggagccaa atgtgtctgt 3720
ggcaagaacc ctgccaagta ctacacctta tttggtcgca gctactga              3768

<210> 385
<211> 39
<212> PRT
<213> Homo sapiens

<400> 385
Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu
 1               5                  10                  15      
Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr
            20                  25                  30          
Thr Leu Phe Gly Arg Ser Tyr
        35                  


<210> 386
<211> 120
<212> DNA
<213> Homo sapiens

<400> 386
atgggagcta aaagcctttg catccccttc aaaccactct gtgaactgca gcctggagcc 60
aaatgtgtct gtggcaagaa ccctgccaag tactacacct tatttggtcg cagctactga 120


<210> 387
<211> 50
<212> DNA
<213> Homo sapiens

<400> 387
tcagatttcc tccagaggcc agtgggttat cttggaagat gttgcaatgt            50

<210> 388
<211> 6
<212> PRT
<213> Homo sapiens

<400> 388
Met Leu His Ile Lys Pro
 1               5              


<210> 389
<211> 50
<212> DNA
<213> Homo sapiens

<400> 389
acatccaggt cacccttttc acaagattgt tcagattcca ttctgtgggg            50

<210> 390
<211> 129
<212> PRT
<213> Homo sapiens

<400> 390
Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala Glu Thr
 1               5                  10                  15      
Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe Thr Arg
            20                  25                  30          
Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn Thr Met Glu
        35                  40                  45              
Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile Pro Phe
    50                  55                  60                  
Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr Ala Arg
65                  70                  75                  80  
Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu
                85                  90                  95      
Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala Lys Cys
            100                 105                 110         
Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly Arg Ser
        115                 120                 125             
Tyr
    


<210> 391
<211> 390
<212> DNA
<213> Homo sapiens

<400> 391
cgagatactg gagaaaagct gacagttgct gaaaatgagg cagagactaa acttcaagct 60
attttggaag acatccaggt cacccttttc acaagggctt ctgaagacct taagactcat 120
atggttgtgg ctaatacaat ggaagacttt cagaagatac tagattctgg aaagattgtt 180
cagattccat tctgtgggga aattgactgt gaggactgga tcaaaaagac cactgccagg 240
gatcaagatc ttgaacctgg tgctccatcc atgggagcta aaagcctttg catccccttc 300
aaaccactct gtgaactgca gcctggagcc aaatgtgtct gtggcaagaa ccctgccaag 360
tactacacct tatttggtcg cagctactga                                  390

<210> 392
<211> 837
<212> PRT
<213> Homo sapiens

<400> 392
Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser
 1               5                  10                  15      
Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp Gly His Thr
            20                  25                  30          
Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ala
        35                  40                  45              
Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro Thr Pro Ser
    50                  55                  60                  
Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val Leu Tyr Asn
65                  70                  75                  80  
Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys
                85                  90                  95      
Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu Leu Ser Leu
            100                 105                 110         
Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn
        115                 120                 125             
Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser
    130                 135                 140                 
Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu
145                 150                 155                 160 
Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn
                165                 170                 175     
Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys
            180                 185                 190         
Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser
        195                 200                 205             
Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro
    210                 215                 220                 
Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val
225                 230                 235                 240 
Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala
                245                 250                 255     
Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly
            260                 265                 270         
Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys
        275                 280                 285             
Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln
    290                 295                 300                 
Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly
305                 310                 315                 320 
Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln
                325                 330                 335     
Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp
            340                 345                 350         
Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile
        355                 360                 365             
Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala
    370                 375                 380                 
Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn
385                 390                 395                 400 
Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys
                405                 410                 415     
Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser
            420                 425                 430         
Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu
        435                 440                 445             
Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp
    450                 455                 460                 
Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe
465                 470                 475                 480 
Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu
                485                 490                 495     
Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu
            500                 505                 510         
Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile
        515                 520                 525             
Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly
    530                 535                 540                 
Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala
545                 550                 555                 560 
Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met
                565                 570                 575     
Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe
            580                 585                 590         
Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met
        595                 600                 605             
Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val
    610                 615                 620                 
Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu
625                 630                 635                 640 
Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg
                645                 650                 655     
Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp
            660                 665                 670         
Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val
        675                 680                 685             
Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe
    690                 695                 700                 
Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn
705                 710                 715                 720 
Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr
                725                 730                 735     
Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala
            740                 745                 750         
Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val
        755                 760                 765             
Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys
    770                 775                 780                 
Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly
785                 790                 795                 800 
Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro
                805                 810                 815     
Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu
            820                 825                 830         
Phe Gly Arg Ser Tyr
        835         


<210> 393
<211> 2514
<212> DNA
<213> Homo sapiens

<400> 393
ggattcttca tatgtgatca accttatgaa cctgttagcc catatagttg caaggaagcc 60
ccgtgtgttt tgatatacat tcctgatggg cacacaaagg aaatgccaac atcagggtca 120
aaggaaaaga ccaaagtaga agccacaaaa aatgagacct ctgctccttt taaggaaaga 180
ccaacacctt ctctgaataa taattgtact acatctgagg attccttggt cctttacaat 240
agagtggctg ttcaaggaga tgtggttcgt gaattaaaag ccaagaaagc accaaaggaa 300
gatgtagatg cagctgtaaa acagcttttg tctttgaaag ctgaatataa ggagaaaact 360
ggccaggaat ataaacctgg aaaccctcct gctgaaatag gacagaatat ttcttctaat 420
tcctcagcaa gtattctgga aagtaaatct ctgtatgatg aagttgctgc acaaggggag 480
gtggttcgta agctaaaagc tgaaaaatcc cctaaggcta aaataaatga agctgtagaa 540
tgcttactgt ccctgaaggc tcagtataaa gaaaaaactg ggaaggagta catacctggt 600
cagcccccat tatctcaaag ttcggattca agcccaacca gaaattctga acctgctggt 660
ttagaaacac cagaagcgaa agtacttttt gacaaagtag cttctcaagg ggaagtagtt 720
cggaaactta aaactgaaaa agcccctaag gatcaagtag atatagctgt tcaagaactc 780
cttcagctaa aggcacagta caagtctttg ataggagtag agtataagcc tgtgtcggcc 840
actggagctg aggacaaaga taagaagaag aaagaaaaag aaaataaatc tgaaaagcag 900
aataagcctc agaaacaaaa tgatggccaa aggaaagacc cttctaaaaa ccaaggaggt 960
gggctctcat caagtggagc aggagaaggg caggggccta agaaacagac caggttgggt 1020
cttgaggcaa aaaaagaaga aaatcttgct gattggtatt ctcaggtcat cacaaagtca 1080
gaaatgattg aataccatga cataagtggc tgttatattc ttcgtccctg ggcctatgcc 1140
atttgggaag ccatcaagga cttttttgat gctgagatca agaaacttgg tgttgaaaac 1200
tgctacttcc ccatgtttgt gtctcaaagt gcattagaga aagagaagac tcatgttgct 1260
gactttgccc cagaggttgc ttgggttaca agatctggca aaaccgagct ggcagaacca 1320
attgccattc gtcctactag tgaaacagta atgtatcctg catatgcaaa atgggtacag 1380
tcacacagag acctgcccat caagctcaat cagtggtgca atgtggtgcg ttgggaattc 1440
aagcatcctc agcctttcct acgtactcgt gaatttcttt ggcaggaagg gcacagtgct 1500
tttgctacca tggaagaggc agcggaagag gtcttgcaga tacttgactt atatgctcag 1560
gtatatgaag aactcctggc aattcctgtt gttaaaggaa gaaagacgga aaaggaaaaa 1620
tttgcaggag gagactatac aactacaata gaagcattta tatctgctag tggaagagct 1680
atccagggag gaacatcaca tcatttaggg cagaattttt ccaaaatgtt tgaaatcgtt 1740
tttgaagatc caaagatacc aggagagaag caatttgcct atcaaaactc ctggggcctg 1800
acaactcgaa ctattggtgt tatgaccatg gttcatgggg acaacatggg tttagtatta 1860
ccaccccgtg tagcatgtgt tcaggtggtg attattcctt gtggcattac caatgcactt 1920
tctgaagaag acaaagaagc gctgattgca aaatgcaatg attatcgaag gcgattactc 1980
agtgttaaca tccgcgttag agctgattta cgagataatt attctccagg ttggaaattc 2040
aatcactggg agctcaaggg agttcccatt agacttgaag ttgggccacg tgatatgaag 2100
agctgtcagt ttgtagccgt cagacgagat actggagaaa agctgacagt tgctgaaaat 2160
gaggcagaga ctaaacttca agctattttg gaagacatcc aggtcaccct tttcacaagg 2220
gcttctgaag accttaagac tcatatggtt gtggctaata caatggaaga ctttcagaag 2280
atactagatt ctggaaagat tgttcagatt ccattctgtg gggaaattga ctgtgaggac 2340
tggatcaaaa agaccactgc cagggatcaa gatcttgaac ctggtgctcc atccatggga 2400
gctaaaagcc tttgcatccc cttcaaacca ctctgtgaac tgcagcctgg agccaaatgt 2460
gtctgtggca agaaccctgc caagtactac accttatttg gtcgcagcta ctga       2514

<210> 394
<211> 644
<212> PRT
<213> Homo sapiens

<400> 394
Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp
 1               5                  10                  15      
Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu
            20                  25                  30          
Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg
        35                  40                  45              
Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val
    50                  55                  60                  
Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val
65                  70                  75                  80  
Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys
                85                  90                  95      
Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys
            100                 105                 110         
Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly
        115                 120                 125             
Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr
    130                 135                 140                 
Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr
145                 150                 155                 160 
Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser
                165                 170                 175     
Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile
            180                 185                 190         
Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys
        195                 200                 205             
Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr
    210                 215                 220                 
His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly
225                 230                 235                 240 
Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr
                245                 250                 255     
Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu
            260                 265                 270         
Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys
        275                 280                 285             
His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly
    290                 295                 300                 
His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln
305                 310                 315                 320 
Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro
                325                 330                 335     
Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp
            340                 345                 350         
Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile
        355                 360                 365             
Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe
    370                 375                 380                 
Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala
385                 390                 395                 400 
Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr
                405                 410                 415     
Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala
            420                 425                 430         
Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser
        435                 440                 445             
Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg
    450                 455                 460                 
Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn
465                 470                 475                 480 
Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro
                485                 490                 495     
Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val
            500                 505                 510         
Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu
        515                 520                 525             
Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu
    530                 535                 540                 
Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn
545                 550                 555                 560 
Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln
                565                 570                 575     
Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr
            580                 585                 590         
Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala
        595                 600                 605             
Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly
    610                 615                 620                 
Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe
625                 630                 635                 640 
Gly Arg Ser Tyr
                


<210> 395
<211> 1935
<212> DNA
<213> Homo sapiens

<400> 395
gggaaggagt acatacctgg tcagccccca ttatctcaaa gttcggattc aagcccaacc 60
agaaattctg aacctgctgg tttagaaaca ccagaagcga aagtactttt tgacaaagta 120
gcttctcaag gggaagtagt tcggaaactt aaaactgaaa aagcccctaa ggatcaagta 180
gatatagctg ttcaagaact ccttcagcta aaggcacagt acaagtcttt gataggagta 240
gagtataagc ctgtgtcggc cactggagct gaggacaaag ataagaagaa gaaagaaaaa 300
gaaaataaat ctgaaaagca gaataagcct cagaaacaaa atgatggcca aaggaaagac 360
ccttctaaaa accaaggagg tgggctctca tcaagtggag caggagaagg gcaggggcct 420
aagaaacaga ccaggttggg tcttgaggca aaaaaagaag aaaatcttgc tgattggtat 480
tctcaggtca tcacaaagtc agaaatgatt gaataccatg acataagtgg ctgttatatt 540
cttcgtccct gggcctatgc catttgggaa gccatcaagg acttttttga tgctgagatc 600
aagaaacttg gtgttgaaaa ctgctacttc cccatgtttg tgtctcaaag tgcattagag 660
aaagagaaga ctcatgttgc tgactttgcc ccagaggttg cttgggttac aagatctggc 720
aaaaccgagc tggcagaacc aattgccatt cgtcctacta gtgaaacagt aatgtatcct 780
gcatatgcaa aatgggtaca gtcacacaga gacctgccca tcaagctcaa tcagtggtgc 840
aatgtggtgc gttgggaatt caagcatcct cagcctttcc tacgtactcg tgaatttctt 900
tggcaggaag ggcacagtgc ttttgctacc atggaagagg cagcggaaga ggtcttgcag 960
atacttgact tatatgctca ggtatatgaa gaactcctgg caattcctgt tgttaaagga 1020
agaaagacgg aaaaggaaaa atttgcagga ggagactata caactacaat agaagcattt 1080
atatctgcta gtggaagagc tatccaggga ggaacatcac atcatttagg gcagaatttt 1140
tccaaaatgt ttgaaatcgt ttttgaagat ccaaagatac caggagagaa gcaatttgcc 1200
tatcaaaact cctggggcct gacaactcga actattggtg ttatgaccat ggttcatggg 1260
gacaacatgg gtttagtatt accaccccgt gtagcatgtg ttcaggtggt gattattcct 1320
tgtggcatta ccaatgcact ttctgaagaa gacaaagaag cgctgattgc aaaatgcaat 1380
gattatcgaa ggcgattact cagtgttaac atccgcgtta gagctgattt acgagataat 1440
tattctccag gttggaaatt caatcactgg gagctcaagg gagttcccat tagacttgaa 1500
gttgggccac gtgatatgaa gagctgtcag tttgtagccg tcagacgaga tactggagaa 1560
aagctgacag ttgctgaaaa tgaggcagag actaaacttc aagctatttt ggaagacatc 1620
caggtcaccc ttttcacaag ggcttctgaa gaccttaaga ctcatatggt tgtggctaat 1680
acaatggaag actttcagaa gatactagat tctggaaaga ttgttcagat tccattctgt 1740
ggggaaattg actgtgagga ctggatcaaa aagaccactg ccagggatca agatcttgaa 1800
cctggtgctc catccatggg agctaaaagc ctttgcatcc ccttcaaacc actctgtgaa 1860
ctgcagcctg gagccaaatg tgtctgtggc aagaaccctg ccaagtacta caccttattt 1920
ggtcgcagct actga                                                  1935

<210> 396
<211> 521
<212> PRT
<213> Homo sapiens

<400> 396
Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn
            20                  25                  30          
Leu Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu
        35                  40                  45              
Tyr His Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala
    50                  55                  60                  
Ile Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu
65                  70                  75                  80  
Gly Val Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu
                85                  90                  95      
Glu Lys Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp
            100                 105                 110         
Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg
        115                 120                 125             
Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln
    130                 135                 140                 
Ser His Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val
145                 150                 155                 160 
Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe
                165                 170                 175     
Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala
            180                 185                 190         
Glu Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu
        195                 200                 205             
Leu Leu Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys
    210                 215                 220                 
Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala
225                 230                 235                 240 
Ser Gly Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn
                245                 250                 255     
Phe Ser Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly
            260                 265                 270         
Glu Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr
        275                 280                 285             
Ile Gly Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu
    290                 295                 300                 
Pro Pro Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile
305                 310                 315                 320 
Thr Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys
                325                 330                 335     
Asn Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala
            340                 345                 350         
Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu
        355                 360                 365             
Leu Lys Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys
    370                 375                 380                 
Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr
385                 390                 395                 400 
Val Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp
                405                 410                 415     
Ile Gln Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His
            420                 425                 430         
Met Val Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser
        435                 440                 445             
Gly Lys Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp
    450                 455                 460                 
Trp Ile Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala
465                 470                 475                 480 
Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys
                485                 490                 495     
Glu Leu Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys
            500                 505                 510         
Tyr Tyr Thr Leu Phe Gly Arg Ser Tyr
        515                 520     


<210> 397
<211> 1566
<212> DNA
<213> Homo sapiens

<400> 397
aaccaaggag gtgggctctc atcaagtgga gcaggagaag ggcaggggcc taagaaacag 60
accaggttgg gtcttgaggc aaaaaaagaa gaaaatcttg ctgattggta ttctcaggtc 120
atcacaaagt cagaaatgat tgaataccat gacataagtg gctgttatat tcttcgtccc 180
tgggcctatg ccatttggga agccatcaag gacttttttg atgctgagat caagaaactt 240
ggtgttgaaa actgctactt ccccatgttt gtgtctcaaa gtgcattaga gaaagagaag 300
actcatgttg ctgactttgc cccagaggtt gcttgggtta caagatctgg caaaaccgag 360
ctggcagaac caattgccat tcgtcctact agtgaaacag taatgtatcc tgcatatgca 420
aaatgggtac agtcacacag agacctgccc atcaagctca atcagtggtg caatgtggtg 480
cgttgggaat tcaagcatcc tcagcctttc ctacgtactc gtgaatttct ttggcaggaa 540
gggcacagtg cttttgctac catggaagag gcagcggaag aggtcttgca gatacttgac 600
ttatatgctc aggtatatga agaactcctg gcaattcctg ttgttaaagg aagaaagacg 660
gaaaaggaaa aatttgcagg aggagactat acaactacaa tagaagcatt tatatctgct 720
agtggaagag ctatccaggg aggaacatca catcatttag ggcagaattt ttccaaaatg 780
tttgaaatcg tttttgaaga tccaaagata ccaggagaga agcaatttgc ctatcaaaac 840
tcctggggcc tgacaactcg aactattggt gttatgacca tggttcatgg ggacaacatg 900
ggtttagtat taccaccccg tgtagcatgt gttcaggtgg tgattattcc ttgtggcatt 960
accaatgcac tttctgaaga agacaaagaa gcgctgattg caaaatgcaa tgattatcga 1020
aggcgattac tcagtgttaa catccgcgtt agagctgatt tacgagataa ttattctcca 1080
ggttggaaat tcaatcactg ggagctcaag ggagttccca ttagacttga agttgggcca 1140
cgtgatatga agagctgtca gtttgtagcc gtcagacgag atactggaga aaagctgaca 1200
gttgctgaaa atgaggcaga gactaaactt caagctattt tggaagacat ccaggtcacc 1260
cttttcacaa gggcttctga agaccttaag actcatatgg ttgtggctaa tacaatggaa 1320
gactttcaga agatactaga ttctggaaag attgttcaga ttccattctg tggggaaatt 1380
gactgtgagg actggatcaa aaagaccact gccagggatc aagatcttga acctggtgct 1440
ccatccatgg gagctaaaag cctttgcatc cccttcaaac cactctgtga actgcagcct 1500
ggagccaaat gtgtctgtgg caagaaccct gccaagtact acaccttatt tggtcgcagc 1560
tactga                                                            1566

<210> 398
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 398
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp
            20                  25                  30          
Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn
        35                  40                  45              
Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn
    50                  55                  60                  
Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro
65                  70                  75                  80  
Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu
                85                  90                  95      
Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr
            100                 105                 110         
His Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile
        115                 120                 125             
Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly
    130                 135                 140                 
Val Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu
145                 150                 155                 160 
Lys Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val
                165                 170                 175     
Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro
            180                 185                 190         
Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser
        195                 200                 205             
His Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg
    210                 215                 220                 
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu
225                 230                 235                 240 
Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu
                245                 250                 255     
Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu
            260                 265                 270         
Leu Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe
        275                 280                 285             
Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser
    290                 295                 300                 
Gly Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe
305                 310                 315                 320 
Ser Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu
                325                 330                 335     
Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile
            340                 345                 350         
Gly Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro
        355                 360                 365             
Pro Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr
    370                 375                 380                 
Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn
385                 390                 395                 400 
Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp
                405                 410                 415     
Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu
            420                 425                 430         
Lys Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser
        435                 440                 445             
Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val
    450                 455                 460                 
Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile
465                 470                 475                 480 
Gln Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met
                485                 490                 495     
Val Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly
            500                 505                 510         
Lys Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp
        515                 520                 525             
Ile Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro
    530                 535                 540                 
Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu
545                 550                 555                 560 
Leu Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr
                565                 570                 575     
Tyr Thr Leu Phe Gly Arg Ser Tyr
            580                 


<210> 399
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      c-terminal 6xHis affinity tag
      
      

<400> 399
Met Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys
 1               5                  10                  15      
Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys
            20                  25                  30          
Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly
        35                  40                  45              
Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr
    50                  55                  60                  
Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr
65                  70                  75                  80  
Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser
                85                  90                  95      
Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile
            100                 105                 110         
Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys
        115                 120                 125             
Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr
    130                 135                 140                 
His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly
145                 150                 155                 160 
Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr
                165                 170                 175     
Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu
            180                 185                 190         
Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys
        195                 200                 205             
His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly
    210                 215                 220                 
His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln
225                 230                 235                 240 
Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro
                245                 250                 255     
Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp
            260                 265                 270         
Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile
        275                 280                 285             
Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe
    290                 295                 300                 
Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala
305                 310                 315                 320 
Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr
                325                 330                 335     
Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala
            340                 345                 350         
Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser
        355                 360                 365             
Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg
    370                 375                 380                 
Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn
385                 390                 395                 400 
Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro
                405                 410                 415     
Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val
            420                 425                 430         
Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu
        435                 440                 445             
Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu
    450                 455                 460                 
Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn
465                 470                 475                 480 
Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln
                485                 490                 495     
Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr
            500                 505                 510         
Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala
        515                 520                 525             
Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly
    530                 535                 540                 
Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe
545                 550                 555                 560 
Gly Arg Ser Tyr Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
                565                 570                 575     
Ser Thr His His His His His His
            580                 


<210> 400
<211> 392
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 400
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg
            20                  25                  30          
Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu
        35                  40                  45              
Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu
    50                  55                  60                  
Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu
65                  70                  75                  80  
Leu Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe
                85                  90                  95      
Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser
            100                 105                 110         
Gly Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe
        115                 120                 125             
Ser Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu
    130                 135                 140                 
Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile
145                 150                 155                 160 
Gly Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro
                165                 170                 175     
Pro Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr
            180                 185                 190         
Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn
        195                 200                 205             
Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp
    210                 215                 220                 
Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu
225                 230                 235                 240 
Lys Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser
                245                 250                 255     
Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val
            260                 265                 270         
Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile
        275                 280                 285             
Gln Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met
    290                 295                 300                 
Val Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly
305                 310                 315                 320 
Lys Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp
                325                 330                 335     
Ile Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro
            340                 345                 350         
Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu
        355                 360                 365             
Leu Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr
    370                 375                 380                 
Tyr Thr Leu Phe Gly Arg Ser Tyr
385                 390         


<210> 401
<211> 392
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      c-terminal 6xHis affinity tag
      
      

<400> 401
Met Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys
 1               5                  10                  15      
His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly
            20                  25                  30          
His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln
        35                  40                  45              
Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro
    50                  55                  60                  
Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp
65                  70                  75                  80  
Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile
                85                  90                  95      
Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe
            100                 105                 110         
Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala
        115                 120                 125             
Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr
    130                 135                 140                 
Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala
145                 150                 155                 160 
Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser
                165                 170                 175     
Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg
            180                 185                 190         
Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn
        195                 200                 205             
Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro
    210                 215                 220                 
Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val
225                 230                 235                 240 
Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu
                245                 250                 255     
Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu
            260                 265                 270         
Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn
        275                 280                 285             
Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln
    290                 295                 300                 
Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr
305                 310                 315                 320 
Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala
                325                 330                 335     
Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly
            340                 345                 350         
Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe
        355                 360                 365             
Gly Arg Ser Tyr Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
    370                 375                 380                 
Ser Thr His His His His His His
385                 390         


<210> 402
<211> 150
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 402
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu
            20                  25                  30          
Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val
        35                  40                  45              
Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val
    50                  55                  60                  
Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile
65                  70                  75                  80  
Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys
                85                  90                  95      
Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met
            100                 105                 110         
Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln
        115                 120                 125             
Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr
    130                 135                 140                 
Leu Phe Gly Arg Ser Tyr
145                 150 


<210> 403
<211> 150
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      c-terminal 6xHis affinity tag
      
      

<400> 403
Met Arg Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala Glu
 1               5                  10                  15      
Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe Thr
            20                  25                  30          
Arg Ala Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn Thr Met
        35                  40                  45              
Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile Pro
    50                  55                  60                  
Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr Ala
65                  70                  75                  80  
Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser
                85                  90                  95      
Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala Lys
            100                 105                 110         
Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly Arg
        115                 120                 125             
Ser Tyr Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
    130                 135                 140                 
His His His His His His
145                 150 


<210> 404
<211> 59
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 404
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro
            20                  25                  30          
Leu Cys Glu Leu Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro
        35                  40                  45              
Ala Lys Tyr Tyr Thr Leu Phe Gly Arg Ser Tyr
    50                  55                  


<210> 405
<211> 59
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      c-terminal 6xHis affinity tag
      
      

<400> 405
Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu
 1               5                  10                  15      
Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr
            20                  25                  30          
Thr Leu Phe Gly Arg Ser Tyr Gly Lys Pro Ile Pro Asn Pro Leu Leu
        35                  40                  45              
Gly Leu Asp Ser Thr His His His His His His
    50                  55                  


<210> 406
<211> 542
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 406
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala
            20                  25                  30          
Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala
        35                  40                  45              
Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys
    50                  55                  60                  
Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly Cys Tyr Ile Leu Arg
65                  70                  75                  80  
Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala
                85                  90                  95      
Glu Ile Lys Lys Leu Gly Val Glu Asn Cys Tyr Phe Pro Met Phe Val
            100                 105                 110         
Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr His Val Ala Asp Phe Ala
        115                 120                 125             
Pro Glu Val Ala Trp Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu
    130                 135                 140                 
Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr
145                 150                 155                 160 
Ala Lys Trp Val Gln Ser His Arg Asp Leu Pro Ile Lys Leu Asn Gln
                165                 170                 175     
Trp Cys Asn Val Val Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu
            180                 185                 190         
Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr
        195                 200                 205             
Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala
    210                 215                 220                 
Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val Lys Gly Arg Lys
225                 230                 235                 240 
Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu
                245                 250                 255     
Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln Gly Gly Thr Ser His
            260                 265                 270         
His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu Ile Val Phe Glu Asp
        275                 280                 285             
Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly
    290                 295                 300                 
Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met Val His Gly Asp Asn
305                 310                 315                 320 
Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys Val Gln Val Val Ile
                325                 330                 335     
Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala
            340                 345                 350         
Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn
        355                 360                 365             
Ile Arg Val Arg Ala Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys
    370                 375                 380                 
Phe Asn His Trp Glu Leu Lys Gly Val Pro Ile Arg Leu Glu Val Gly
385                 390                 395                 400 
Pro Arg Asp Met Lys Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr
                405                 410                 415     
Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln
            420                 425                 430         
Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe Thr Arg Ala Ser Glu
        435                 440                 445             
Asp Leu Lys Thr His Met Val Val Ala Asn Thr Met Glu Asp Phe Gln
    450                 455                 460                 
Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile Pro Phe Cys Gly Glu
465                 470                 475                 480 
Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr Ala Arg Asp Gln Asp
                485                 490                 495     
Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro
            500                 505                 510         
Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala Lys Cys Val Cys Gly
        515                 520                 525             
Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly Arg Ser Tyr
    530                 535                 540         


<210> 407
<211> 542
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      
      

<400> 407
Met Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln
 1               5                  10                  15      
Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu
            20                  25                  30          
Asn Leu Ala Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile
        35                  40                  45              
Glu Tyr His Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr
    50                  55                  60                  
Ala Ile Trp Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys
65                  70                  75                  80  
Leu Gly Val Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala
                85                  90                  95      
Leu Glu Lys Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala
            100                 105                 110         
Trp Val Thr Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile
        115                 120                 125             
Arg Pro Thr Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val
    130                 135                 140                 
Gln Ser His Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val
145                 150                 155                 160 
Val Arg Trp Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu
                165                 170                 175     
Phe Leu Trp Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala
            180                 185                 190         
Ala Glu Glu Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu
        195                 200                 205             
Glu Leu Leu Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu
    210                 215                 220                 
Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser
225                 230                 235                 240 
Ala Ser Gly Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln
                245                 250                 255     
Asn Phe Ser Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro
            260                 265                 270         
Gly Glu Lys Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg
        275                 280                 285             
Thr Ile Gly Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val
    290                 295                 300                 
Leu Pro Pro Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly
305                 310                 315                 320 
Ile Thr Asn Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys
                325                 330                 335     
Cys Asn Asp Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg
            340                 345                 350         
Ala Asp Leu Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp
        355                 360                 365             
Glu Leu Lys Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met
    370                 375                 380                 
Lys Ser Cys Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu
385                 390                 395                 400 
Thr Val Ala Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu
                405                 410                 415     
Asp Ile Gln Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr
            420                 425                 430         
His Met Val Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp
        435                 440                 445             
Ser Gly Lys Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu
    450                 455                 460                 
Asp Trp Ile Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly
465                 470                 475                 480 
Ala Pro Ser Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu
                485                 490                 495     
Cys Glu Leu Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala
            500                 505                 510         
Lys Tyr Tyr Thr Leu Phe Gly Arg Ser Tyr Gly Lys Pro Ile Pro Asn
        515                 520                 525             
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
    530                 535                 540         


<210> 408
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 8xHis affinity tag
      
      

<400> 408
Met Ala Ser Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser Gln
 1               5                  10                  15      
Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu Glu
            20                  25                  30          
Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu
        35                  40                  45              
Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp
    50                  55                  60                  
Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu
65                  70                  75                  80  
Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys
                85                  90                  95      
Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys
            100                 105                 110         
Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln
        115                 120                 125             
Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys
    130                 135                 140                 
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala
145                 150                 155                 160 
Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His
                165                 170                 175     
Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp
            180                 185                 190         
Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val
        195                 200                 205             
Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys
    210                 215                 220                 
Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr
225                 230                 235                 240 
Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr
                245                 250                 255     
Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His
            260                 265                 270         
Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp
        275                 280                 285             
Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp
    290                 295                 300                 
Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu
305                 310                 315                 320 
Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu
                325                 330                 335     
Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala
            340                 345                 350         
Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly
        355                 360                 365             
Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser
    370                 375                 380                 
Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys
385                 390                 395                 400 
Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly
                405                 410                 415     
Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro
            420                 425                 430         
Arg Val Ala Cys Val Gln Val Val Ile Ile Pro Cys Gly Ile Thr Asn
        435                 440                 445             
Ala Leu Ser Glu Glu Asp Lys Glu Ala Leu Ile Ala Lys Cys Asn Asp
    450                 455                 460                 
Tyr Arg Arg Arg Leu Leu Ser Val Asn Ile Arg Val Arg Ala Asp Leu
465                 470                 475                 480 
Arg Asp Asn Tyr Ser Pro Gly Trp Lys Phe Asn His Trp Glu Leu Lys
                485                 490                 495     
Gly Val Pro Ile Arg Leu Glu Val Gly Pro Arg Asp Met Lys Ser Cys
            500                 505                 510         
Gln Phe Val Ala Val Arg Arg Asp Thr Gly Glu Lys Leu Thr Val Ala
        515                 520                 525             
Glu Asn Glu Ala Glu Thr Lys Leu Gln Ala Ile Leu Glu Asp Ile Gln
    530                 535                 540                 
Val Thr Leu Phe Thr Arg Ala Ser Glu Asp Leu Lys Thr His Met Val
545                 550                 555                 560 
Val Ala Asn Thr Met Glu Asp Phe Gln Lys Ile Leu Asp Ser Gly Lys
                565                 570                 575     
Ile Val Gln Ile Pro Phe Cys Gly Glu Ile Asp Cys Glu Asp Trp Ile
            580                 585                 590         
Lys Lys Thr Thr Ala Arg Asp Gln Asp Leu Glu Pro Gly Ala Pro Ser
        595                 600                 605             
Met Gly Ala Lys Ser Leu Cys Ile Pro Phe Lys Pro Leu Cys Glu Leu
    610                 615                 620                 
Gln Pro Gly Ala Lys Cys Val Cys Gly Lys Asn Pro Ala Lys Tyr Tyr
625                 630                 635                 640 
Thr Leu Phe Gly Arg Ser Tyr Val Asp Lys Leu Ala Ala Ala Leu Glu
                645                 650                 655     
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
            660                 665                 670         
His His His His His His
        675             


<210> 409
<211> 1701
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 409
tacaaaccag ttagcgcaac cggcgcagag gacaaggata aaaagaagaa agagaaagag 60
aacaagagcg agaagcagaa taaaccgcag aagcaaaatg acggccagcg taaagacccg 120
agcaagaatc agggcggtgg cctgtctagc agcggtgcgg gcgagggtca aggtccgaag 180
aaacaaaccc gtctgggcct ggaggcgaag aaagaagaaa atctggcaga ttggtactcc 240
caggttatta ccaaatctga aatgattgaa tatcatgaca ttagcggttg ttacatcctg 300
cgcccgtggg cctacgccat ctgggaagct attaaagact tcttcgatgc agagattaag 360
aaactgggcg tcgaaaactg ttacttccct atgttcgtga gccaaagcgc actggagaaa 420
gagaaaacgc acgttgcgga ctttgccccg gaagtcgcat gggtcacccg tagcggcaag 480
accgagctgg ccgagccgat tgcgatccgt ccgacgagcg agactgtcat gtacccggct 540
tacgcgaagt gggtgcagag ccatcgcgat ctgccgatca agctgaacca gtggtgcaac 600
gtggtccgtt gggagttcaa acatcctcag ccgttcctgc gcacccgtga gtttctgtgg 660
caagagggtc attccgcatt cgccactatg gaagaagcgg ctgaagaggt tttgcagatt 720
ctggatctgt acgcgcaagt ttatgaagaa ctgctggcca ttccagtggt taagggtcgc 780
aaaacggaga aagagaaatt tgcgggtggc gactatacca ccacgattga ggcgtttatc 840
tccgcaagcg gccgcgccat tcaaggcggt accagccacc acttgggtca gaacttctcg 900
aaaatgtttg aaattgtgtt cgaggacccg aagattccgg gtgagaaaca attcgcgtat 960
cagaattcct ggggtctgac cacccgcacg atcggcgtga tgacgatggt tcacggtgat 1020
aacatgggtc tggtgctgcc gccgcgcgtt gcgtgcgtcc aagttgtgat tatcccgtgc 1080
ggtattacca atgcactgag cgaagaggac aaagaagcac tgatcgctaa gtgtaatgac 1140
taccgtcgtc gtctgctgag cgtcaacatt cgtgttcgtg ctgatctgcg tgataactat 1200
agcccgggtt ggaagtttaa tcactgggaa ctgaagggtg ttccgatccg tctggaggtt 1260
ggtccgcgcg atatgaagag ctgtcagttc gtcgcggttc gccgcgacac gggtgagaag 1320
ttgaccgtgg cggagaacga agcagaaact aagctgcaag ccatcttgga agatatccaa 1380
gtcaccttgt tcacccgtgc gagcgaagat ctgaaaaccc acatggtcgt ggcgaacacg 1440
atggaggatt ttcagaagat cctggactct ggcaaaatcg ttcagatccc attttgcggt 1500
gaaatcgact gcgaggattg gattaagaaa acgacggctc gtgaccagga cctggagccg 1560
ggcgcgccga gcatgggtgc gaaatcgctg tgtatcccgt ttaagccttt gtgcgagctg 1620
caaccgggtg caaaatgcgt gtgtggcaag aatccggcga aatattatac cctgtttggc 1680
cgtagctact aatgactcga g                                           1701

<210> 410
<211> 1125
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 410
atcaaactga accaatggtg caacgtagtc cgctgggaat tcaaacatcc gcagccgttc 60
ctgcgtaccc gcgagtttct gtggcaggaa ggccattctg cctttgcgac tatggaagag 120
gccgcagaag aggtcctgca gattctggac ttgtacgcgc aagtttacga agagttgttg 180
gcgattccgg tcgtcaaggg ccgtaagacc gagaaagaga aattcgcggg tggcgattat 240
accacgacga tcgaggcgtt catcagcgcg tccggtcgtg caattcaggg tggtacctcg 300
catcacctgg gtcaaaactt tagcaaaatg ttcgagatcg tgttcgagga cccgaagatt 360
ccgggtgaga agcaattcgc atatcagaac agctggggcc tgacgacccg tacgatcggt 420
gtgatgacga tggttcacgg cgataatatg ggtctggtgc tgccgcctcg tgtcgcgtgc 480
gttcaagttg ttatcattcc atgcggcatc accaatgcgc tgtctgaaga agataaagag 540
gcactgatcg ctaagtgtaa cgactaccgc cgccgtctgt tgagcgtcaa catccgtgtc 600
cgcgccgatc tgcgtgacaa ctacagcccg ggttggaaat ttaatcactg ggaactgaag 660
ggtgttccga ttcgcctgga ggttggtcct cgcgacatga agtcctgcca gttcgtggcg 720
gtgcgtcgcg acacgggtga aaagctgacc gttgcagaga atgaagctga aactaaactg 780
caagcgattc tggaagatat tcaagtgacc ctgtttaccc gtgccagcga agatctgaaa 840
acccacatgg ttgtcgccaa tacgatggag gactttcaga aaatcctgga cagcggcaaa 900
atcgtgcaaa ttccgttctg cggcgaaatc gactgtgagg attggatcaa gaaaaccacc 960
gcacgtgatc aggacttgga accgggcgca ccgagcatgg gtgctaaaag cctgtgtatt 1020
ccgtttaagc cactgtgcga gctgcagccg ggcgccaagt gtgtgtgcgg taagaacccg 1080
gcgaaatatt ataccctgtt cggtcgtagc tactaatgac tcgag                 1125

<210> 411
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 411
cgcgacacgg gcgagaaact gacggtggcg gagaacgaag cagaaaccaa gctgcaagca 60
atcctggagg acattcaggt tacgctgttc acccgtgcat ccgaagattt gaaaactcac 120
atggttgtgg cgaatacgat ggaggatttc cagaaaattc tggacagcgg taaaatcgtc 180
caaatcccgt tttgcggtga gatcgactgt gaggattgga ttaagaaaac cacggcgcgt 240
gaccaagatc tggaaccggg tgccccatct atgggcgcca aaagcctgtg cattccgttc 300
aaaccgctgt gtgagctgca gccgggcgcg aagtgtgtgt gcggtaagaa cccggctaag 360
tactatacct tgtttggccg cagctactaa tgactcgag                        399

<210> 412
<211> 126
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 412
ggcgccaaat ccctgtgcat ccctttcaag ccactgtgcg agctgcagcc gggcgcgaaa 60
tgtgtttgcg gtaagaaccc ggcaaaatac tacaccctgt tcggtcgtag ctattaatga 120
ctcgag                                                            126

<210> 413
<211> 1575
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 413
aaccaaggtg gcggtctgag cagcagcggc gcaggtgagg gtcagggtcc gaagaaacaa 60
acccgtctgg gcctggaagc caagaaagaa gagaacttgg cagactggta cagccaggtg 120
atcacgaaaa gcgagatgat cgagtatcat gacattagcg gttgttacat tctgcgtccg 180
tgggcctatg cgatctggga ggctattaag gatttcttcg acgcggaaat caagaaattg 240
ggcgttgaaa attgttactt tccgatgttc gttagccaaa gcgcactgga gaaagagaaa 300
acgcacgtgg cagacttcgc gccggaggtg gcgtgggtta cccgtagcgg caaaactgag 360
ctggcggaac cgatcgcgat tcgtccgacc agcgagactg tcatgtaccc ggcttatgct 420
aagtgggtcc aaagccatcg tgacttgccg atcaaactga accaatggtg taatgtcgtg 480
cgctgggagt ttaagcaccc gcaaccgttt ctgcgtaccc gcgagtttct gtggcaagag 540
ggtcattctg cgttcgccac gatggaagag gcggcggaag aggtcctgca gattctggac 600
ctgtatgctc aggtgtatga agagctgctg gctatcccgg ttgtgaaggg tcgtaagacc 660
gagaaagaga aatttgcagg tggtgattac accacgacca tcgaagcatt catttccgcg 720
agcggtcgcg caattcaggg tggtacgtcc caccatctgg gtcagaactt ctcgaagatg 780
ttcgaaatcg ttttcgagga cccgaagatt ccaggcgaga aacagttcgc ataccaaaat 840
agctggggtc tgaccacgcg taccattggt gttatgacga tggtccacgg cgataacatg 900
ggtttggttc tgccgccgcg tgtggcgtgc gttcaagtcg tgattatccc gtgcggtatt 960
accaacgcat tgagcgaaga ggacaaagaa gctctgattg ccaaatgcaa tgattaccgt 1020
cgtcgcctgc tgagcgtcaa tatccgtgtc cgtgcggacc tgcgcgacaa ctattctccg 1080
ggttggaagt ttaaccactg ggaattgaag ggcgtgccga ttcgtctgga agtgggccct 1140
cgcgatatga agtcgtgcca gttcgttgcg gtccgtcgcg acaccggcga gaaactgacc 1200
gtcgccgaaa acgaggccga gactaagctg caggcgatcc tggaagatat tcaagtgacg 1260
ctgtttaccc gtgcatccga agatttgaaa acccacatgg ttgttgcgaa tacgatggag 1320
gactttcaga agatcctgga tagcggtaaa atcgtgcaga ttccgttttg tggcgaaatt 1380
gattgcgaag attggatcaa gaaaaccacg gcccgcgacc aagatctgga gccgggcgcc 1440
ccaagcatgg gtgcgaagag cctgtgtatc ccgttcaagc ctctgtgcga gctgcagcca 1500
ggcgcgaaat gtgtgtgcgg caagaatcct gcgaaatact acaccctgtt tggtcgcagc 1560
tattaatgac tcgag                                                  1575

<210> 414
<211> 272
<212> PRT
<213> Homo sapiens

<400> 414
Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg
 1               5                  10                  15      
Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val
            20                  25                  30          
Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln
        35                  40                  45              
Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser
    50                  55                  60                  
Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu
65                  70                  75                  80  
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser
                85                  90                  95      
Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
            100                 105                 110         
Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro
        115                 120                 125             
Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro
    130                 135                 140                 
Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala
145                 150                 155                 160 
Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys
                165                 170                 175     
Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln
            180                 185                 190         
Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly
        195                 200                 205             
Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu
    210                 215                 220                 
Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro
225                 230                 235                 240 
Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly
                245                 250                 255     
Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu
            260                 265                 270         


<210> 415
<211> 816
<212> DNA
<213> Homo sapiens

<400> 415
tccttggtcc tttacaatag agtggctgtt caaggagatg tggttcgtga attaaaagcc 60
aagaaagcac caaaggaaga tgtagatgca gctgtaaaac agcttttgtc tttgaaagct 120
gaatataagg agaaaactgg ccaggaatat aaacctggaa accctcctgc tgaaatagga 180
cagaatattt cttctaattc ctcagcaagt attctggaaa gtaaatctct gtatgatgaa 240
gttgctgcac aaggggaggt ggttcgtaag ctaaaagctg aaaaatcccc taaggctaaa 300
ataaatgaag ctgtagaatg cttactgtcc ctgaaggctc agtataaaga aaaaactggg 360
aaggagtaca tacctggtca gcccccatta tctcaaagtt cggattcaag cccaaccaga 420
aattctgaac ctgctggttt agaaacacca gaagcgaaag tactttttga caaagtagct 480
tctcaagggg aagtagttcg gaaacttaaa actgaaaaag cccctaagga tcaagtagat 540
atagctgttc aagaactcct tcagctaaag gcacagtaca agtctttgat aggagtagag 600
tataagcctg tgtcggccac tggagctgag gacaaagata agaagaagaa agaaaaagaa 660
aataaatctg aaaagcagaa taagcctcag aaacaaaatg atggccaaag gaaagaccct 720
tctaaaaacc aaggaggtgg gctctcatca agtggagcag gagaagggca ggggcctaag 780
aaacagacca ggttgggtct tgaggcaaaa aaagaa                           816

<210> 416
<211> 319
<212> PRT
<213> Homo sapiens

<400> 416
Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser
 1               5                  10                  15      
Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu
            20                  25                  30          
Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser Gln
        35                  40                  45              
Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly Cys
    50                  55                  60                  
Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys Asp
65                  70                  75                  80  
Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys Tyr Phe
                85                  90                  95      
Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr His Val
            100                 105                 110         
Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly Lys Thr
        115                 120                 125             
Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val Met
    130                 135                 140                 
Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu Pro Ile
145                 150                 155                 160 
Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys His Pro
                165                 170                 175     
Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His Ser
            180                 185                 190         
Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile Leu
        195                 200                 205             
Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val
    210                 215                 220                 
Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr Thr
225                 230                 235                 240 
Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln Gly
                245                 250                 255     
Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu Ile
            260                 265                 270         
Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr Gln
        275                 280                 285             
Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met Val
    290                 295                 300                 
His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys
305                 310                 315                 


<210> 417
<211> 957
<212> DNA
<213> Homo sapiens

<400> 417
gatggccaaa ggaaagaccc ttctaaaaac caaggaggtg ggctctcatc aagtggagca 60
ggagaagggc aggggcctaa gaaacagacc aggttgggtc ttgaggcaaa aaaagaagaa 120
aatcttgctg attggtattc tcaggtcatc acaaagtcag aaatgattga ataccatgac 180
ataagtggct gttatattct tcgtccctgg gcctatgcca tttgggaagc catcaaggac 240
ttttttgatg ctgagatcaa gaaacttggt gttgaaaact gctacttccc catgtttgtg 300
tctcaaagtg cattagagaa agagaagact catgttgctg actttgcccc agaggttgct 360
tgggttacaa gatctggcaa aaccgagctg gcagaaccaa ttgccattcg tcctactagt 420
gaaacagtaa tgtatcctgc atatgcaaaa tgggtacagt cacacagaga cctgcccatc 480
aagctcaatc agtggtgcaa tgtggtgcgt tgggaattca agcatcctca gcctttccta 540
cgtactcgtg aatttctttg gcaggaaggg cacagtgctt ttgctaccat ggaagaggca 600
gcggaagagg tcttgcagat acttgactta tatgctcagg tatatgaaga actcctggca 660
attcctgttg ttaaaggaag aaagacggaa aaggaaaaat ttgcaggagg agactataca 720
actacaatag aagcatttat atctgctagt ggaagagcta tccagggagg aacatcacat 780
catttagggc agaatttttc caaaatgttt gaaatcgttt ttgaagatcc aaagatacca 840
ggagagaagc aatttgccta tcaaaactcc tggggcctga caactcgaac tattggtgtt 900
atgaccatgg ttcatgggga caacatgggt ttagtattac caccccgtgt agcatgt    957

<210> 418
<211> 21
<212> PRT
<213> Mus musculus

<400> 418
Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val Gln
 1               5                  10                  15      
Thr Val Ser Thr Lys
            20      


<210> 419
<211> 14
<212> PRT
<213> Mus musculus

<400> 419
Ser Ser Ser Asn Thr Val Glu Ser Thr Ser Leu Tyr Asn Lys
 1               5                  10                  


<210> 420
<211> 162
<212> PRT
<213> Mus musculus

<400> 420
Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala
 1               5                  10                  15      
Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys Leu Leu Ser Leu Lys
            20                  25                  30          
Ala Glu Tyr Lys Glu Lys Thr Gly Lys Asp Tyr Val Pro Gly Gln Pro
        35                  40                  45              
Pro Ala Ser Gln Asn Ser His Ser Asn Pro Val Ser Asn Ala Gln Pro
    50                  55                  60                  
Ala Gly Ala Glu Lys Pro Glu Ala Lys Val Leu Phe Asp Arg Val Ala
65                  70                  75                  80  
Cys Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ala Ser Lys
                85                  90                  95      
Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln
            100                 105                 110         
Tyr Lys Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser Ala Thr Gly
        115                 120                 125             
Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu
    130                 135                 140                 
Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Gly Lys Asp Ser
145                 150                 155                 160 
Ser Lys
        


<210> 421
<211> 18
<212> PRT
<213> Mus musculus

<400> 421
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 422
<211> 215
<212> PRT
<213> Mus musculus

<400> 422
Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Ser Ala Ala Ala Val Gln
 1               5                  10                  15      
Thr Val Ser Thr Lys Ser Ser Ser Asn Thr Val Glu Ser Thr Ser Leu
            20                  25                  30          
Tyr Asn Lys Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala
        35                  40                  45              
Glu Lys Ala Pro Lys Ala Lys Val Thr Glu Ala Val Glu Cys Leu Leu
    50                  55                  60                  
Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Lys Asp Tyr Val Pro
65                  70                  75                  80  
Gly Gln Pro Pro Ala Ser Gln Asn Ser His Ser Asn Pro Val Ser Asn
                85                  90                  95      
Ala Gln Pro Ala Gly Ala Glu Lys Pro Glu Ala Lys Val Leu Phe Asp
            100                 105                 110         
Arg Val Ala Cys Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys
        115                 120                 125             
Ala Ser Lys Asp Gln Val Asp Ser Ala Val Gln Glu Leu Leu Gln Leu
    130                 135                 140                 
Lys Ala Gln Tyr Lys Ser Leu Thr Gly Ile Glu Tyr Lys Pro Val Ser
145                 150                 155                 160 
Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn
                165                 170                 175     
Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Gly
            180                 185                 190         
Lys Asp Ser Ser Lys Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala
        195                 200                 205             
Gly Glu Gly Gln Gly Pro Lys
    210                 215 


<210> 423
<211> 18
<212> PRT
<213> Mus musculus

<400> 423
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys
        


<210> 424
<211> 10
<212> PRT
<213> Mus musculus

<400> 424
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys
 1               5                  10  


<210> 425
<211> 15
<212> PRT
<213> Mus musculus

<400> 425
Lys Glu Glu Asn Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys
 1               5                  10                  15  


<210> 426
<211> 36
<212> PRT
<213> Mus musculus

<400> 426
Ser Glu Met Ile Glu Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg
 1               5                  10                  15      
Pro Trp Ser Tyr Ser Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala
            20                  25                  30          
Glu Ile Lys Lys
        35      


<210> 427
<211> 19
<212> PRT
<213> Mus musculus

<400> 427
Leu Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala
 1               5                  10                  15      
Leu Glu Lys
            


<210> 428
<211> 98
<212> PRT
<213> Mus musculus

<400> 428
Ser Gln Gly Ser Gly Leu Ser Ser Gly Gly Ala Gly Glu Gly Gln Gly
 1               5                  10                  15      
Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn
            20                  25                  30          
Leu Ala Glu Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu
        35                  40                  45              
Tyr Tyr Asp Val Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ser Tyr Ser
    50                  55                  60                  
Ile Trp Glu Ser Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu
65                  70                  75                  80  
Gly Val Glu Asn Cys Tyr Phe Pro Ile Phe Val Ser Gln Ala Ala Leu
                85                  90                  95      
Glu Lys
        


<210> 429
<211> 344
<212> PRT
<213> Homo sapiens

<400> 429
Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Lys Glu Ala Pro Cys
 1               5                  10                  15      
Val Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr Ser
            20                  25                  30          
Gly Ser Lys Glu Lys Thr Lys Val Glu Ala Thr Lys Asn Glu Thr Ser
        35                  40                  45              
Ala Pro Phe Lys Glu Arg Pro Thr Pro Ser Leu Asn Asn Asn Cys Thr
    50                  55                  60                  
Thr Ser Glu Asp Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln Gly
65                  70                  75                  80  
Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Val
                85                  90                  95      
Asp Ala Ala Val Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys Glu
            100                 105                 110         
Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile Gly
        115                 120                 125             
Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys Ser
    130                 135                 140                 
Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys
145                 150                 155                 160 
Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys Leu
                165                 170                 175     
Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr Ile
            180                 185                 190         
Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr Arg
        195                 200                 205             
Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu Phe
    210                 215                 220                 
Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr Glu
225                 230                 235                 240 
Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu Gln
                245                 250                 255     
Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro Val
            260                 265                 270         
Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu
        275                 280                 285             
Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln
    290                 295                 300                 
Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly
305                 310                 315                 320 
Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu
                325                 330                 335     
Ala Lys Lys Glu Glu Asn Leu Ala
            340                 


<210> 430
<211> 1032
<212> DNA
<213> Homo sapiens

<400> 430
caaccttatg aacctgttag cccatatagt tgcaaggaag ccccgtgtgt tttgatatac 60
attcctgatg ggcacacaaa ggaaatgcca acatcagggt caaaggaaaa gaccaaagta 120
gaagccacaa aaaatgagac ctctgctcct tttaaggaaa gaccaacacc ttctctgaat 180
aataattgta ctacatctga ggattccttg gtcctttaca atagagtggc tgttcaagga 240
gatgtggttc gtgaattaaa agccaagaaa gcaccaaagg aagatgtaga tgcagctgta 300
aaacagcttt tgtctttgaa agctgaatat aaggagaaaa ctggccagga atataaacct 360
ggaaaccctc ctgctgaaat aggacagaat atttcttcta attcctcagc aagtattctg 420
gaaagtaaat ctctgtatga tgaagttgct gcacaagggg aggtggttcg taagctaaaa 480
gctgaaaaat cccctaaggc taaaataaat gaagctgtag aatgcttact gtccctgaag 540
gctcagtata aagaaaaaac tgggaaggag tacatacctg gtcagccccc attatctcaa 600
agttcggatt caagcccaac cagaaattct gaacctgctg gtttagaaac accagaagcg 660
aaagtacttt ttgacaaagt agcttctcaa ggggaagtag ttcggaaact taaaactgaa 720
aaagccccta aggatcaagt agatatagct gttcaagaac tccttcagct aaaggcacag 780
tacaagtctt tgataggagt agagtataag cctgtgtcgg ccactggagc tgaggacaaa 840
gataagaaga agaaagaaaa agaaaataaa tctgaaaagc agaataagcc tcagaaacaa 900
aatgatggcc aaaggaaaga cccttctaaa aaccaaggag gtgggctctc atcaagtgga 960
gcaggagaag ggcaggggcc taagaaacag accaggttgg gtcttgaggc aaaaaaagaa 1020
gaaaatcttg ct                                                     1032

<210> 431
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 431
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln
            20                  25                  30          
Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp
        35                  40                  45              
Val Asp Ala Ala Val Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys
    50                  55                  60                  
Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile
65                  70                  75                  80  
Gly Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys
                85                  90                  95      
Ser Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu
            100                 105                 110         
Lys Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys
        115                 120                 125             
Leu Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr
    130                 135                 140                 
Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr
145                 150                 155                 160 
Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu
                165                 170                 175     
Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr
            180                 185                 190         
Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu
        195                 200                 205             
Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro
    210                 215                 220                 
Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys
225                 230                 235                 240 
Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly
                245                 250                 255     
Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser
            260                 265                 270         
Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu
        275                 280                 285             
Glu Ala Lys Lys Glu
    290             


<210> 432
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      
      

<400> 432
Met Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val
 1               5                  10                  15      
Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala
            20                  25                  30          
Val Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly
        35                  40                  45              
Gln Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile
    50                  55                  60                  
Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp
65                  70                  75                  80  
Glu Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys
                85                  90                  95      
Ser Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu
            100                 105                 110         
Lys Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln
        115                 120                 125             
Pro Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu
    130                 135                 140                 
Pro Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val
145                 150                 155                 160 
Ala Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro
                165                 170                 175     
Lys Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala
            180                 185                 190         
Gln Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr
        195                 200                 205             
Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser
    210                 215                 220                 
Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp
225                 230                 235                 240 
Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu
                245                 250                 255     
Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys
            260                 265                 270         
Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
        275                 280                 285             
His His His His His
    290             


<210> 433
<211> 340
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 433
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln
            20                  25                  30          
Gly Gly Gly Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys
        35                  40                  45              
Lys Gln Thr Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala
    50                  55                  60                  
Asp Trp Tyr Ser Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His
65                  70                  75                  80  
Asp Ile Ser Gly Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp
                85                  90                  95      
Glu Ala Ile Lys Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val
            100                 105                 110         
Glu Asn Cys Tyr Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys
        115                 120                 125             
Glu Lys Thr His Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr
    130                 135                 140                 
Arg Ser Gly Lys Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr
145                 150                 155                 160 
Ser Glu Thr Val Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His
                165                 170                 175     
Arg Asp Leu Pro Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp
            180                 185                 190         
Glu Phe Lys His Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp
        195                 200                 205             
Gln Glu Gly His Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu
    210                 215                 220                 
Val Leu Gln Ile Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu
225                 230                 235                 240 
Ala Ile Pro Val Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala
                245                 250                 255     
Gly Gly Asp Tyr Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly
            260                 265                 270         
Arg Ala Ile Gln Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser
        275                 280                 285             
Lys Met Phe Glu Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys
    290                 295                 300                 
Gln Phe Ala Tyr Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly
305                 310                 315                 320 
Val Met Thr Met Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro
                325                 330                 335     
Arg Val Ala Cys
            340 


<210> 434
<211> 340
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      
      

<400> 434
Met Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu
 1               5                  10                  15      
Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg
            20                  25                  30          
Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser
        35                  40                  45              
Gln Val Ile Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly
    50                  55                  60                  
Cys Tyr Ile Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys
65                  70                  75                  80  
Asp Phe Phe Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys Tyr
                85                  90                  95      
Phe Pro Met Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr His
            100                 105                 110         
Val Ala Asp Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly Lys
        115                 120                 125             
Thr Glu Leu Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val
    130                 135                 140                 
Met Tyr Pro Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu Pro
145                 150                 155                 160 
Ile Lys Leu Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys His
                165                 170                 175     
Pro Gln Pro Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His
            180                 185                 190         
Ser Ala Phe Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile
        195                 200                 205             
Leu Asp Leu Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val
    210                 215                 220                 
Val Lys Gly Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr
225                 230                 235                 240 
Thr Thr Thr Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln
                245                 250                 255     
Gly Gly Thr Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu
            260                 265                 270         
Ile Val Phe Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr
        275                 280                 285             
Gln Asn Ser Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met
    290                 295                 300                 
Val His Gly Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys
305                 310                 315                 320 
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
                325                 330                 335     
His His His His
            340 


<210> 435
<211> 365
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      
      

<400> 435
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys
            20                  25                  30          
Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp Gly His Thr Lys
        35                  40                  45              
Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ala Thr
    50                  55                  60                  
Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro Thr Pro Ser Leu
65                  70                  75                  80  
Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val Leu Tyr Asn Arg
                85                  90                  95      
Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala
            100                 105                 110         
Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu Leu Ser Leu Lys
        115                 120                 125             
Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro
    130                 135                 140                 
Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile
145                 150                 155                 160 
Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu Val
                165                 170                 175     
Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn Glu
            180                 185                 190         
Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys Thr
        195                 200                 205             
Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp
    210                 215                 220                 
Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu
225                 230                 235                 240 
Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg
                245                 250                 255     
Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val
            260                 265                 270         
Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val
        275                 280                 285             
Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys
    290                 295                 300                 
Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys
305                 310                 315                 320 
Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly
                325                 330                 335     
Leu Ser Ser Ser Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr
            340                 345                 350         
Arg Leu Gly Leu Glu Ala Lys Lys Glu Glu Asn Leu Ala
        355                 360                 365 


<210> 436
<211> 365
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glutamylprolyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      
      

<400> 436
Met Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Lys Glu Ala Pro
 1               5                  10                  15      
Cys Val Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr
            20                  25                  30          
Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ala Thr Lys Asn Glu Thr
        35                  40                  45              
Ser Ala Pro Phe Lys Glu Arg Pro Thr Pro Ser Leu Asn Asn Asn Cys
    50                  55                  60                  
Thr Thr Ser Glu Asp Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln
65                  70                  75                  80  
Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp
                85                  90                  95      
Val Asp Ala Ala Val Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys
            100                 105                 110         
Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile
        115                 120                 125             
Gly Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys
    130                 135                 140                 
Ser Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu
145                 150                 155                 160 
Lys Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys
                165                 170                 175     
Leu Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr
            180                 185                 190         
Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr
        195                 200                 205             
Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu
    210                 215                 220                 
Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr
225                 230                 235                 240 
Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu
                245                 250                 255     
Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro
            260                 265                 270         
Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys
        275                 280                 285             
Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly
    290                 295                 300                 
Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser
305                 310                 315                 320 
Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu
                325                 330                 335     
Glu Ala Lys Lys Glu Glu Asn Leu Ala Gly Lys Pro Ile Pro Asn Pro
            340                 345                 350         
Leu Leu Gly Leu Asp Ser Thr His His His His His His
        355                 360                 365 


<210> 437
<211> 828
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 437
agcttggtct tgtacaaccg cgtagcagtc caaggtgacg tcgtccgtga gttgaaggcc 60
aagaaagcgc cgaaagaaga tgtggacgcg gcagttaagc agctgctgag cctgaaagcg 120
gaatataaag agaaaacggg ccaggaatac aaaccaggta atccgccggc cgagatcggt 180
cagaacatta gcagcaattc cagcgcgagc atcctggaga gcaaaagcct gtatgacgag 240
gttgctgccc aaggtgaggt tgtccgtaag ctgaaagcgg agaagtctcc gaaggcgaag 300
atcaatgaag ccgtggaatg cctgctgtcc ctgaaggcgc aatacaaaga aaagacgggc 360
aaagaataca ttccgggcca accgccgctg tcccagagca gcgatagctc tccgacccgc 420
aatagcgagc ctgcgggctt ggaaaccccg gaggctaagg tgctgttcga caaagttgcg 480
agccaaggtg aggtggtgcg taagctgaaa accgagaaag caccgaaaga tcaagtcgac 540
atcgccgttc aggaactgct gcagctgaag gcacaataca agtctctgat tggtgtcgaa 600
tataaaccgg ttagcgcaac cggcgctgag gacaaggata agaagaagaa agagaaagaa 660
aacaagagcg aaaagcagaa caaaccgcag aaacagaacg acggtcaacg taaagatccg 720
agcaagaacc aaggtggtgg tctgtcgagc tccggtgcag gcgagggtca aggtccaaag 780
aaacagactc gcctgggctt ggaggcgaag aaagagtaat gactcgag              828

<210> 438
<211> 969
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 438
gacggccagc gcaaggaccc gagcaaaaac caaggcggcg gcctgagcag cagcggcgcg 60
ggtgagggcc agggtccgaa gaaacaaacc cgtttgggtc tggaagccaa gaaagaagag 120
aacctggcgg actggtacag ccaagtgatc accaagagcg agatgatcga ataccacgat 180
atcagcggct gttacatcct gcgcccgtgg gcgtacgcga tttgggaagc aattaaggat 240
ttcttcgacg ccgagattaa gaaactgggt gtggagaact gctatttccc gatgtttgtt 300
agccaatccg ctctggagaa agagaaaacg cacgttgccg atttcgcgcc ggaagtggcg 360
tgggtcacgc gttccggtaa aaccgaactg gctgagccga ttgcgatccg ccctaccagc 420
gagactgtca tgtatccggc atacgcaaag tgggtgcagt cgcaccgcga tctgccaatt 480
aagctgaacc aatggtgtaa tgtcgttcgt tgggagttta agcatccgca gccgtttctg 540
cgtacccgtg agttcctgtg gcaggaaggc cactctgctt ttgccacgat ggaagaagcg 600
gcggaagagg ttctgcaaat cctggacttg tacgcacagg tttatgaaga gctgctggct 660
attccggtgg tgaaaggtcg caaaactgag aaagagaagt tcgcgggcgg cgactatacc 720
acgaccatcg aagcgtttat tagcgccagc ggtcgtgcga tccagggtgg tactagccac 780
catctgggcc agaatttcag caaaatgttt gagattgtct ttgaggatcc gaaaattccg 840
ggtgaaaagc agttcgcata tcaaaactct tggggtttga ccacccgtac catcggtgtc 900
atgacgatgg ttcatggtga caatatgggc ctggttctgc caccgcgtgt ggcatgctaa 960
tgactcgag                                                         969

<210> 439
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glutamylprolyl tRNA Synthetase
      polynucleotide
      
      

<400> 439
caaccgtacg agccagtaag cccatacagc tgcaaagaag ccccgtgcgt tctgatttac 60
atccctgacg gccacacgaa agaaatgccg acgtctggtt ctaaagaaaa gaccaaggtg 120
gaggctacca agaacgagac ttccgcgccg ttcaaagagc gtccgacccc gagcctgaat 180
aacaactgca cgaccagcga agattctctg gttctgtata accgtgtggc agtgcaaggt 240
gatgtcgtgc gcgagttgaa ggcgaagaaa gctccgaaag aggacgtcga cgcggcagtt 300
aagcagctgt tgtccctgaa agcggagtac aaagaaaaga cgggtcaaga atataagccg 360
ggcaacccgc cggcagaaat cggccagaat atcagcagca acagcagcgc aagcattctg 420
gagtcgaaaa gcctgtacga cgaggtcgct gcgcagggtg aggttgtgcg taaactgaag 480
gccgagaaat ctcctaaagc gaaaatcaat gaagccgttg aatgtttgct gagcctgaaa 540
gcccagtata aagagaaaac cggtaaagag tacattccag gtcagccgcc gctgagccag 600
agcagcgatt ccagcccgac gcgcaatagc gaaccagcag gtctggaaac cccggaagcg 660
aaagtcctgt ttgacaaggt cgcgagccaa ggcgaggtgg ttcgtaagct gaaaactgag 720
aaggcaccta aggaccaagt cgatattgcc gtgcaagagc tgctgcagct gaaggcgcag 780
tacaagagcc tgatcggtgt tgaatataaa ccggtgtccg ccaccggtgc agaggataaa 840
gacaagaaga agaaagagaa agaaaataaa tcggaaaagc agaataagcc gcagaagcaa 900
aacgatggcc aacgtaagga cccgagcaag aaccagggcg gcggtctgag cagcagcggc 960
gctggtgagg gtcaaggccc gaagaaacaa acccgcttgg gtctggaggc caagaaagaa 1020
gaaaatctgg cgtaatgact cgag                                        1044

<210> 440
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide

<400> 440
ccggatatca tggcgacgct ctctctgacc gtg                              33

<210> 441
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 441
atagtttagc ggccgcgtag ctgcgaccaa ataaggtgta gtac                  44

<210> 442
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 442
ggatggctag cgggaaggag tacatacctg gtcag                            35

<210> 443
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 443
gtccgtcgac gtagctgcga ccaaataagg tg                               32

<210> 444
<211> 96
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide
      
      

<400> 444
gtcgacaagc ttgcggccgc actcgagggt aagcctatcc ctaaccctct cctcggtctc 60
gattctacgc atcatcacca ccaccaccac cactga                           96
