                         SEQUENCE LISTING

<110>  CROWE, Michael A.
       ALVIZO, Oscar
       BEHROUZIAN, Behnaz
       BONG, Yong Koy
       COLLIER, Steven
       GOHEL, Anupam
       MAVINAHALLI, Jagadeesh
       MODUKURU, Naga
       MUNDORFF, Emily
       SMITH, Derek
       SONG, Shiwei
       YEO, Wan Lin
 
<120>  BIOCATALYSTS FOR EZETIMIBE SYNTHESIS

<130>  CX2-037USP1

<160>  168   

<170>  PatentIn version 3.5

<210>  1
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  1
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac cggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  2
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  2

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  3
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  3
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg taatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  4
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  4

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Val Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  5
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  5
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  6
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  6

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  7
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  7
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  8
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  8

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  9
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  9
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct gataggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  10

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Ile Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  11
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  11
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggccga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  12
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  12

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Ala Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  13
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  13
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgac acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  14
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  14

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Thr Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  15
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  15
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactggttaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  16
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  16

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  17
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  17
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctgtctga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  18
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  18

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Ser Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  19
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  19
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctgtgtga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  20
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  20

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Cys Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  21
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  21
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctgaatga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  22
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  22

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Asn Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  23
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  23
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtttggagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  24
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  24

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Leu Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  25
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  25
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtaatgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  26
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  26

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Asn Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  27
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  27
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatggtgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgttgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  28
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  28

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Val Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Val Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  29
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  29
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggccc ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  30
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  30

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Pro Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  31
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  31
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactgggcaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  32
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  32

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gly 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  33
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  33
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cactggctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  34
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  34

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Ala 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  35
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  35
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  36
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  36

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  37
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  37
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctggtgaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgaccga taaatttcca      600

ggtgctgagg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  38
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  38

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  39
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  39
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgatgactga taaatttcca      600

ggtgctgagg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  40
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  40

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Met Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  41
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  41
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatctg tcagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  42
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  42

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Cys Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  43
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  43
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatcat tcagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  44
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  44

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Ile Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  45
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  45
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgagg aaatgatcaa tcagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  46
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  46

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Glu Glu Met Ile Asn Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  47
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  47
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg cccgtaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat ccgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcgggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg ggtttttttc      360

ggcacccgtc tgggcattaa acgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

gacgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  48
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  48

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  49
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  49
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

tttgcaatcg cccgtaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg ggtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

gacgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  50
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  50

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Phe Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  51
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  51
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  52
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  52

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  53
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  53
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccactaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  54
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  54

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  55
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  55
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggccat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  56
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  56

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly His Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  57
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  57
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccg atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  58
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  58

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  59
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  59
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg caatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  60
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  60

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Ala Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  61
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  61
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctggtg taatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  62
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  62

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Val Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  63
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  63
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aagtgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  64
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  64

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Val Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  65
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  65
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgaatatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  66
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  66

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Asn Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  67
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  67
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgtttatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  68
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  68

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Phe Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  69
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  69
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctggcaaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatcac ccagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  70
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  70

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Ala 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Thr Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  71
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  71
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccaacaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta cggatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  72
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  72

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asn Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  73
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  73
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccacaaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtgctgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  74
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  74

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  75
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  75
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcca ctctgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgatcg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgatgactga taaatttcca      600

ggtgctgggg aaatgatctg ccagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  76
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  76

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Thr Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Ile Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Met Thr Asp Lys Phe Pro Gly Ala Gly Glu Met Ile Cys Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  77
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  77
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgagcaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg cgcaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  78
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  78

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  79
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  79
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  80
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  80

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  81
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  81
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctggcgaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  82
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  82

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Ala 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  83
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  83
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgacgaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  84
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  84

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Thr 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  85
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  85
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg aagaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  86
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  86

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  87
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  87
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg ggtgttacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  88
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  88

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Cys Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  89
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  89
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

attggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  90
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  90

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ile Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  91
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  91
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ttgggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  92
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  92

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Leu Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  93
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  93
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gctggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  94
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  94

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  95
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  95
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgttttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctgtgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttccg      600

ggtggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  96
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  96

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Val Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  97
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  97
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctatgaacaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

attggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  98
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  98

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Met Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ile Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  99
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  99
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  100
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  100

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  101
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  101
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

tttgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  102
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  102

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Phe Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  103
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  103
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  104
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  104

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  105
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  105
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

tttgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  106
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  106

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Phe Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  107
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  107
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  108
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  108

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  109
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  109
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

tttgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcgatcc gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  110
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  110

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Phe Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  111
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  111
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  112
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  112

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  113
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  113
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  114
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  114

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  115
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  115
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  116
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  116

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  117
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  117
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttagcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg ggacaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  118
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  118

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Asp Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  119
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  119
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  120
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  120

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  121
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  121
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  122
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  122

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  123
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  123
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  124
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  124

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  125
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  125
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttagcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  126
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  126

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  127
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  127
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttagcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gaaaaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattaa gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  128
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  128

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Lys Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Lys Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  129
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  129
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttagcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  130
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  130

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  131
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  131
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

cgcgcaatcg cccgcaaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

gatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  132
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  132

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Arg Ala Ile Ala Arg Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asp Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  133
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  133
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggacgt ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  134
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  134

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Thr Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  135
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  135
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggccg cgctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aaatgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  136
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  136

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ala Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  137
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  137
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcaggggcct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

ggtggtgggg aagtgatctc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  138
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  138

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ala Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Gly Gly Gly Glu Val Ile Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  139
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  139
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgc ggtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  140
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  140

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ala Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  141
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  141
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatgg ggtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  142
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  142

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  143
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  143
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatggcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  144
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  144

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Trp Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  145
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  145
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  146
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  146

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Met Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  147
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  147
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg tgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  148
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  148

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  149
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  149
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacattg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  150
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  150

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  151
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  151
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggct ggtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgatgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  152
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  152

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Met Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  153
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  153
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcgttgaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat tgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  154
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  154

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  155
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  155
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcataaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aagtgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catgggtgtg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  156
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  156

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Val Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  157
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  157
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcataaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catgggtgtg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  158
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  158

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  159
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  159
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aagtgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  160
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  160

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Val Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  161
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  161
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcataaactg ttgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catgggtgtg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  162
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  162

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  163
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  163
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcataaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aagtgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  164
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  164

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Val Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  165
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  165
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcgcaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatttcca      600

gcaggtgggg aagtgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catgggtgtg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  166
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  166

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Phe Pro Ala Gly Gly Glu Val Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  167
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  167
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac cggtcgccgt      120

gcagatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg tgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatct ctctgcctaa aagcctggaa      300

gacactacca cggaggaatg gcataaactg ttgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagctcga tcagtgggat cgtaggcgat ccgatgttgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgct atcaagaccc cgctgactga taaatggcca      600

gcaggtgggg aaatgatctc acagcgtacg aaaaccccta tgggccacat tggtgaaccg      660

aatgacgtgg catgggtgtg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

agcgaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  168
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir ketoreductase

<400>  168

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Leu Pro 
                85                  90                  95      


Lys Ser Leu Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Ile Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Thr Asp Lys Trp Pro Ala Gly Gly Glu Met Ile Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


