
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited		
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN
  FRAGMENTS OF METHIONYL-TRNA SYNTHETASES  

<130> 120161.462pc

<140> PCT                 
<141> 2011-05-03  

<150> US 61/330,596       
<151> 2010-05-03  

<150> US 61/331,282       
<151> 2010-05-04  

<160> 176

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 231
<212> PRT
<213> Homo sapiens

<400> 12
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu
225                 230     


<210> 13
<211> 693
<212> DNA
<213> Homo sapiens

<400> 13
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gag                              693

<210> 14
<211> 19
<212> PRT
<213> Mus musculus

<400> 14
Leu Phe Val Ser Glu Gly Ser Pro Gly Ser Leu Pro Val Leu Ala Ala
 1               5                  10                  15      
Ala Ala Arg
            


<210> 15
<211> 22
<212> PRT
<213> Mus musculus

<400> 15
Gly Arg Ala Glu Leu Leu Ile Ser Thr Val Gly Pro Glu Glu Cys Val
 1               5                  10                  15      
Val Pro Phe Leu Thr Arg
            20          


<210> 16
<211> 20
<212> PRT
<213> Mus musculus

<400> 16
Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Ala Ser
 1               5                  10                  15      
Ala Ile Cys Arg
            20  


<210> 17
<211> 137
<212> PRT
<213> Mus musculus

<400> 17
Tyr Phe Phe Leu Leu Cys Gly Trp Glu Gln Asp Asp Leu Thr Asn Gln
 1               5                  10                  15      
Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Val Leu Ser Ala Ala
            20                  25                  30          
Leu His Cys Leu Val Val Gln Gly Lys Lys Gly Glu Asp Ile Leu Gly
        35                  40                  45              
Pro Leu Arg Arg Val Leu Thr His Ile Asp His Ser Leu Ser Arg Gln
    50                  55                  60                  
Asn Cys Pro Phe Leu Ala Gly Asp Thr Glu Ser Leu Ala Asp Ile Val
65                  70                  75                  80  
Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala Tyr Leu Pro
                85                  90                  95      
Glu Glu Leu Gly Ala Leu Gln Ser Trp Phe Gln Thr Leu Ser Thr Gln
            100                 105                 110         
Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln Gln Gly Val
        115                 120                 125             
Leu Ala Leu Arg Leu Tyr Leu Gln Lys
    130                 135         


<210> 18
<211> 12
<212> PRT
<213> Mus musculus

<400> 18
Gln Pro Gln Pro Gln Pro Pro Pro Pro Glu Gly Arg
 1               5                  10          


<210> 19
<211> 214
<212> PRT
<213> Mus musculus

<400> 19
Leu Phe Val Ser Glu Gly Ser Pro Gly Ser Leu Pro Val Leu Ala Ala
 1               5                  10                  15      
Ala Ala Arg Ala Arg Gly Arg Ala Glu Leu Leu Ile Ser Thr Val Gly
            20                  25                  30          
Pro Glu Glu Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val Pro Val
        35                  40                  45              
Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Ala Ser Ala Ile Cys
    50                  55                  60                  
Arg Tyr Phe Phe Leu Leu Cys Gly Trp Glu Gln Asp Asp Leu Thr Asn
65                  70                  75                  80  
Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Val Leu Ser Ala
                85                  90                  95      
Ala Leu His Cys Leu Val Val Gln Gly Lys Lys Gly Glu Asp Ile Leu
            100                 105                 110         
Gly Pro Leu Arg Arg Val Leu Thr His Ile Asp His Ser Leu Ser Arg
        115                 120                 125             
Gln Asn Cys Pro Phe Leu Ala Gly Asp Thr Glu Ser Leu Ala Asp Ile
    130                 135                 140                 
Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala Tyr Leu
145                 150                 155                 160 
Pro Glu Glu Leu Gly Ala Leu Gln Ser Trp Phe Gln Thr Leu Ser Thr
                165                 170                 175     
Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln Gln Gly
            180                 185                 190         
Val Leu Ala Leu Arg Leu Tyr Leu Gln Lys Gln Pro Gln Pro Gln Pro
        195                 200                 205             
Pro Pro Pro Glu Gly Arg
    210                 


<210> 20
<211> 115
<212> PRT
<213> Homo sapiens

<400> 20
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Ser Met Ser Gly Leu Met Pro Leu Leu Ala Ile Cys
65                  70                  75                  80  
Pro Ser Gln Pro Thr Thr Gln Thr Ser Gly Arg Asp Gly Gly Arg Thr
                85                  90                  95      
Gln Ser Lys Trp Thr Cys Ile Ser Ser Trp Pro Lys Thr Met Phe Leu
            100                 105                 110         
Ser Ile Ala
        115 


<210> 21
<211> 348
<212> DNA
<213> Homo sapiens

<400> 21
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg gtattctatg tctggtttga tgccactatt ggctatctgt 240
ccatcacagc caactacaca gaccagtggg agagatggtg gaagaaccca gagcaagtgg 300
acctgtatca gttcatggcc aaagacaatg ttcctttcca tagcttag              348

<210> 22
<211> 427
<212> PRT
<213> Homo sapiens

<400> 22
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ser Leu Ser Val
        355                 360                 365             
Lys Ser Ala Asp His Ala Leu Trp Cys Ser Arg Ala Ser Thr Cys Phe
    370                 375                 380                 
Trp Thr Cys Leu Ser Trp Arg Ser Asp Trp Arg Ser Gly Trp Gly Gly
385                 390                 395                 400 
His Cys Leu Ala Val Thr Gly His Pro Met Pro Ser Leu Ser Pro Val
                405                 410                 415     
Leu Gly Phe Gly Met Ala Ser Ser His Ala Ala
            420                 425         


<210> 23
<211> 1284
<212> DNA
<213> Homo sapiens

<400> 23
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaagcctcag tgtaaagtct gccgatcatg ccctgtggtg cagtcgagcc 1140
agcacctgtt tctggacctg cctaagctgg agaagcgact ggaggagtgg ttggggagga 1200
cattgcctgg cagtgactgg acacccaatg cccagtttat cacccgttct tggcttcggg 1260
atggcctcaa gccacgctgc ataa                                        1284

<210> 24
<211> 868
<212> PRT
<213> Homo sapiens

<400> 24
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430         
Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445             
His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460                 
Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 
Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495     
Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510         
Lys Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His
        515                 520                 525             
Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr
    530                 535                 540                 
Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly
545                 550                 555                 560 
Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln
                565                 570                 575     
Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile
            580                 585                 590         
Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu
        595                 600                 605             
Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg
    610                 615                 620                 
Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met
625                 630                 635                 640 
Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu
                645                 650                 655     
Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala
            660                 665                 670         
Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln
        675                 680                 685             
Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln
    690                 695                 700                 
Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu
705                 710                 715                 720 
Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln
                725                 730                 735     
Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn
            740                 745                 750         
Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro
        755                 760                 765             
Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg
    770                 775                 780                 
Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu
785                 790                 795                 800 
Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu
                805                 810                 815     
Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala
            820                 825                 830         
Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys
        835                 840                 845             
Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly
    850                 855                 860                 
Lys Lys Lys Lys
865             


<210> 25
<211> 2607
<212> DNA
<213> Homo sapiens

<400> 25
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaatcaccca ggacattttc cagcagttgc tgaaacgagg ttttgtgctg 1140
caagatactg tggagcaact gcgatgtgag cactgtgctc gcttcctggc tgaccgcttc 1200
gtggagggcg tgtgtccctt ctgtggctat gaggaggctc ggggtgacca gtgtgacaag 1260
tgtggcaagc tcatcaatgc tgtcgagctt aagaagcctc agtgtaaagt ctgccgatca 1320
tgccctgtgg tgcagtcgag ccagcacctg tttctggacc tgcctaagct ggagaagcga 1380
ctggaggagt ggttggggag gacattgcct ggcagtgact ggacacccaa tgcccagttt 1440
atcacccgtt cttggcttcg ggatggcctc aagccacgct gcataacccg agacctcaaa 1500
tggggaaccc ctgtaccctt agaaggtttt gaagacaagg tggacctgta tcagttcatg 1560
gccaaagaca atgttccttt ccatagctta gtctttcctt gctcagccct aggagctgag 1620
gataactata ccttggtcag ccacctcatt gctacagagt acctgaacta tgaggatggg 1680
aaattctcta agagccgcgg tgtgggagtg tttggggaca tggcccagga cacggggatc 1740
cctgctgaca tctggcgctt ctatctgctg tacattcggc ctgagggcca ggacagtgct 1800
ttctcctgga cggacctgct gctgaagaat aattctgagc tgcttaacaa cctgggcaac 1860
ttcatcaaca gagctgggat gtttgtgtct aagttctttg ggggctatgt gcctgagatg 1920
gtgctcaccc ctgatgatca gcgcctgctg gcccatgtca ccctggagct ccagcactat 1980
caccagctac ttgagaaggt tcggatccgg gatgccttgc gcagtatcct caccatatct 2040
cgacatggca accaatatat tcaggtgaat gagccctgga agcggattaa aggcagtgag 2100
gctgacaggc aacgggcagg aacagtgact ggcttggcag tgaatatagc tgccttgctc 2160
tctgtcatgc ttcagcctta catgcccacg gttagtgcca caatccaggc ccagctgcag 2220
ctcccacctc cagcctgcag tatcctgctg acaaacttcc tgtgtacctt accagcagga 2280
caccagattg gcacagtcag tcccttgttc caaaaattgg aaaatgacca gattgaaagt 2340
ttaaggcagc gctttggagg gggccaggca aaaacgtccc cgaagccagc agttgtagag 2400
actgttacaa cagccaagcc acagcagata caagcgctga tggatgaagt gacaaaacaa 2460
ggaaacattg tccgagaact gaaagcacaa aaggcagaca agaacgaggt tgctgcggag 2520
gtggcgaaac tcttggatct aaagaaacag ttggctgtag ctgaggggaa accccctgaa 2580
gcccctaaag gcaagaagaa aaagtaa                                     2607

<210> 26
<211> 547
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430         
Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445             
His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460                 
Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 
Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495     
Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510         
Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile
        515                 520                 525             
Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu
    530                 535                 540                 
Gln Ser Thr
545         


<210> 27
<211> 1644
<212> DNA
<213> Homo sapiens

<400> 27
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaatcaccca ggacattttc cagcagttgc tgaaacgagg ttttgtgctg 1140
caagatactg tggagcaact gcgatgtgag cactgtgctc gcttcctggc tgaccgcttc 1200
gtggagggcg tgtgtccctt ctgtggctat gaggaggctc ggggtgacca gtgtgacaag 1260
tgtggcaagc tcatcaatgc tgtcgagctt aagaagcctc agtgtaaagt ctgccgatca 1320
tgccctgtgg tgcagtcgag ccagcacctg tttctggacc tgcctaagct ggagaagcga 1380
ctggaggagt ggttggggag gacattgcct ggcagtgact ggacacccaa tgcccagttt 1440
atcacccgtt cttggcttcg ggatggcctc aagccacgct gcataacccg agacctcaaa 1500
tggggaaccc ctgtaccctt agaaggtttt gaagacaagg tattctatgt ctggtttgat 1560
gccactattg gctatctgtc catcacagcc aactacacag accagtggga gagatggtgg 1620
aagaacccag agcaaagtac ctga                                        1644

<210> 28
<211> 750
<212> PRT
<213> Homo sapiens

<400> 28
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430         
Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445             
His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460                 
Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 
Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495     
Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510         
Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile
        515                 520                 525             
Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu
    530                 535                 540                 
Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His
545                 550                 555                 560 
Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr
                565                 570                 575     
Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly
            580                 585                 590         
Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln
        595                 600                 605             
Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile
    610                 615                 620                 
Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu
625                 630                 635                 640 
Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg
                645                 650                 655     
Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met
            660                 665                 670         
Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu
        675                 680                 685             
Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala
    690                 695                 700                 
Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln
705                 710                 715                 720 
Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Ser
                725                 730                 735     
Val Pro Cys Ser Lys Asn Trp Lys Met Thr Arg Leu Lys Val
            740                 745                 750 


<210> 29
<211> 2253
<212> DNA
<213> Homo sapiens

<400> 29
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaatcaccca ggacattttc cagcagttgc tgaaacgagg ttttgtgctg 1140
caagatactg tggagcaact gcgatgtgag cactgtgctc gcttcctggc tgaccgcttc 1200
gtggagggcg tgtgtccctt ctgtggctat gaggaggctc ggggtgacca gtgtgacaag 1260
tgtggcaagc tcatcaatgc tgtcgagctt aagaagcctc agtgtaaagt ctgccgatca 1320
tgccctgtgg tgcagtcgag ccagcacctg tttctggacc tgcctaagct ggagaagcga 1380
ctggaggagt ggttggggag gacattgcct ggcagtgact ggacacccaa tgcccagttt 1440
atcacccgtt cttggcttcg ggatggcctc aagccacgct gcataacccg agacctcaaa 1500
tggggaaccc ctgtaccctt agaaggtttt gaagacaagg tattctatgt ctggtttgat 1560
gccactattg gctatctgtc catcacagcc aactacacag accagtggga gagatggtgg 1620
aagaacccag agcaagtgga cctgtatcag ttcatggcca aagacaatgt tcctttccat 1680
agcttagtct ttccttgctc agccctagga gctgaggata actatacctt ggtcagccac 1740
ctcattgcta cagagtacct gaactatgag gatgggaaat tctctaagag ccgcggtgtg 1800
ggagtgtttg gggacatggc ccaggacacg gggatccctg ctgacatctg gcgcttctat 1860
ctgctgtaca ttcggcctga gggccaggac agtgctttct cctggacgga cctgctgctg 1920
aagaataatt ctgagctgct taacaacctg ggcaacttca tcaacagagc tgggatgttt 1980
gtgtctaagt tctttggggg ctatgtgcct gagatggtgc tcacccctga tgatcagcgc 2040
ctgctggccc atgtcaccct ggagctccag cactatcacc agctacttga gaaggttcgg 2100
atccgggatg ccttgcgcag tatcctcacc atatctcgac atggcaacca atatattcag 2160
gtgaatgagc cctggaagcg gattaaaggc agtgaggctg acaggtcagt cccttgttcc 2220
aaaaattgga aaatgaccag attgaaagtt taa                              2253

<210> 30
<211> 869
<212> PRT
<213> Homo sapiens

<400> 30
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430         
Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445             
His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460                 
Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 
Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495     
Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510         
Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile
        515                 520                 525             
Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu
    530                 535                 540                 
Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His
545                 550                 555                 560 
Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr
                565                 570                 575     
Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly
            580                 585                 590         
Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln
        595                 600                 605             
Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile
    610                 615                 620                 
Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu
625                 630                 635                 640 
Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg
                645                 650                 655     
Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met
            660                 665                 670         
Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu
        675                 680                 685             
Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala
    690                 695                 700                 
Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln
705                 710                 715                 720 
Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln
                725                 730                 735     
Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu
            740                 745                 750         
Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln
        755                 760                 765             
Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn
    770                 775                 780                 
Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro
785                 790                 795                 800 
Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg
                805                 810                 815     
Phe Gly Gly Gly Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys
            820                 825                 830         
Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu
        835                 840                 845             
Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys
    850                 855                 860                 
Gly Lys Lys Lys Lys
865                 


<210> 31
<211> 2610
<212> DNA
<213> Homo sapiens

<400> 31
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaatcaccca ggacattttc cagcagttgc tgaaacgagg ttttgtgctg 1140
caagatactg tggagcaact gcgatgtgag cactgtgctc gcttcctggc tgaccgcttc 1200
gtggagggcg tgtgtccctt ctgtggctat gaggaggctc ggggtgacca gtgtgacaag 1260
tgtggcaagc tcatcaatgc tgtcgagctt aagaagcctc agtgtaaagt ctgccgatca 1320
tgccctgtgg tgcagtcgag ccagcacctg tttctggacc tgcctaagct ggagaagcga 1380
ctggaggagt ggttggggag gacattgcct ggcagtgact ggacacccaa tgcccagttt 1440
atcacccgtt cttggcttcg ggatggcctc aagccacgct gcataacccg agacctcaaa 1500
tggggaaccc ctgtaccctt agaaggtttt gaagacaagg tattctatgt ctggtttgat 1560
gccactattg gctatctgtc catcacagcc aactacacag accagtggga gagatggtgg 1620
aagaacccag agcaagtgga cctgtatcag ttcatggcca aagacaatgt tcctttccat 1680
agcttagtct ttccttgctc agccctagga gctgaggata actatacctt ggtcagccac 1740
ctcattgcta cagagtacct gaactatgag gatgggaaat tctctaagag ccgcggtgtg 1800
ggagtgtttg gggacatggc ccaggacacg gggatccctg ctgacatctg gcgcttctat 1860
ctgctgtaca ttcggcctga gggccaggac agtgctttct cctggacgga cctgctgctg 1920
aagaataatt ctgagctgct taacaacctg ggcaacttca tcaacagagc tgggatgttt 1980
gtgtctaagt tctttggggg ctatgtgcct gagatggtgc tcacccctga tgatcagcgc 2040
ctgctggccc atgtcaccct ggagctccag cactatcacc agctacttga gaaggttcgg 2100
atccgggatg ccttgcgcag tatcctcacc atatctcgac atggcaacca atatattcag 2160
gtgaatgagc cctggaagcg gattaaaggc agtgaggctg acaggcaacg ggcaggaaca 2220
gtgactggct tggcagtgaa tatagctgcc ttgctctctg tcatgcttca gccttacatg 2280
cccacggtta gtgccacaat ccaggcccag ctgcagctcc cacctccagc ctgcagtatc 2340
ctgctgacaa acttcctgtg taccttacca gcaggacacc agattggcac agtcagtccc 2400
ttgttccaaa aattggaaaa tgaccagatt gaaagtttaa ggcagcgctt tggagggggc 2460
cagggaaaca ttgtccgaga actgaaagca caaaaggcag acaagaacga ggttgctgcg 2520
gaggtggcga aactcttgga tctaaagaaa cagttggctg tagctgaggg gaaaccccct 2580
gaagccccta aaggcaagaa gaaaaagtaa                                  2610

<210> 32
<211> 114
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Gly Ala Glu Cys Pro Ala Gln Leu Val Pro Asp Thr Glu
65                  70                  75                  80  
Tyr Pro Gly Thr Met Ser Ala Ser Cys Arg Asp Cys Thr Glu Thr Ala
                85                  90                  95      
Arg Cys Pro Gly Ser Pro Ala Leu Pro Pro Lys Ala Ala Pro Ala Gln
            100                 105                 110         
Pro Arg
        


<210> 33
<211> 345
<212> DNA
<213> Homo sapiens

<400> 33
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg aggagctgag tgccctgcac agctggttcc agacactgag 240
tacccaggaa ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc 300
tctccggcct tacctccaaa agcagcccca gcccagcccc gctga                 345

<210> 34
<211> 276
<212> PRT
<213> Homo sapiens

<400> 34
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Val Ala Cys
    210                 215                 220                 
Gly Trp Arg Lys Glu Cys Ala His His Gln Cys Pro Pro Leu Arg Gln
225                 230                 235                 240 
Gln Cys Pro Pro Pro Trp Glu His His Trp Leu Cys Ala Gln Cys Arg
                245                 250                 255     
Cys Leu Cys Gln Val Leu Ser Pro Pro Pro Val Glu His Pro Leu Ser
            260                 265                 270         
Val Trp Asp Arg
        275     


<210> 35
<211> 831
<212> DNA
<213> Homo sapiens

<400> 35
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggttgcct gtggctggag aaaggaatgt gctcatcacc agtgccctcc cttacgtcaa 720
caatgtcccc caccttggga acatcattgg ttgtgtgctc agtgccgatg tctttgccag 780
gtactctcgc ctccgccagt ggaacaccct ctatctgtgt gggacagatg a          831

<210> 36
<211> 273
<212> PRT
<213> Homo sapiens

<400> 36
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Trp Thr Cys Ile Ser Ser Trp Pro Lys Thr Met Phe Leu Ser Ile
            260                 265                 270         
Ala
    


<210> 37
<211> 822
<212> DNA
<213> Homo sapiens

<400> 37
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gtggacctgt 780
atcagttcat ggccaaagac aatgttcctt tccatagctt ag                    822

<210> 38
<211> 876
<212> PRT
<213> Homo sapiens

<400> 38
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430         
Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445             
His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460                 
Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 
Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495     
Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510         
Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile
        515                 520                 525             
Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu
    530                 535                 540                 
Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His
545                 550                 555                 560 
Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr
                565                 570                 575     
Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly
            580                 585                 590         
Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln
        595                 600                 605             
Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile
    610                 615                 620                 
Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu
625                 630                 635                 640 
Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg
                645                 650                 655     
Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met
            660                 665                 670         
Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu
        675                 680                 685             
Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala
    690                 695                 700                 
Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln
705                 710                 715                 720 
Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln
                725                 730                 735     
Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu
            740                 745                 750         
Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln
        755                 760                 765             
Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn
    770                 775                 780                 
Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Ala Lys Thr
785                 790                 795                 800 
Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr Thr Ala Lys Pro Gln
                805                 810                 815     
Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val
            820                 825                 830         
Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu
        835                 840                 845             
Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly
    850                 855                 860                 
Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
865                 870                 875     


<210> 39
<211> 2631
<212> DNA
<213> Homo sapiens

<400> 39
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaatcaccca ggacattttc cagcagttgc tgaaacgagg ttttgtgctg 1140
caagatactg tggagcaact gcgatgtgag cactgtgctc gcttcctggc tgaccgcttc 1200
gtggagggcg tgtgtccctt ctgtggctat gaggaggctc ggggtgacca gtgtgacaag 1260
tgtggcaagc tcatcaatgc tgtcgagctt aagaagcctc agtgtaaagt ctgccgatca 1320
tgccctgtgg tgcagtcgag ccagcacctg tttctggacc tgcctaagct ggagaagcga 1380
ctggaggagt ggttggggag gacattgcct ggcagtgact ggacacccaa tgcccagttt 1440
atcacccgtt cttggcttcg ggatggcctc aagccacgct gcataacccg agacctcaaa 1500
tggggaaccc ctgtaccctt agaaggtttt gaagacaagg tattctatgt ctggtttgat 1560
gccactattg gctatctgtc catcacagcc aactacacag accagtggga gagatggtgg 1620
aagaacccag agcaagtgga cctgtatcag ttcatggcca aagacaatgt tcctttccat 1680
agcttagtct ttccttgctc agccctagga gctgaggata actatacctt ggtcagccac 1740
ctcattgcta cagagtacct gaactatgag gatgggaaat tctctaagag ccgcggtgtg 1800
ggagtgtttg gggacatggc ccaggacacg gggatccctg ctgacatctg gcgcttctat 1860
ctgctgtaca ttcggcctga gggccaggac agtgctttct cctggacgga cctgctgctg 1920
aagaataatt ctgagctgct taacaacctg ggcaacttca tcaacagagc tgggatgttt 1980
gtgtctaagt tctttggggg ctatgtgcct gagatggtgc tcacccctga tgatcagcgc 2040
ctgctggccc atgtcaccct ggagctccag cactatcacc agctacttga gaaggttcgg 2100
atccgggatg ccttgcgcag tatcctcacc atatctcgac atggcaacca atatattcag 2160
gtgaatgagc cctggaagcg gattaaaggc agtgaggctg acaggcaacg ggcaggaaca 2220
gtgactggct tggcagtgaa tatagctgcc ttgctctctg tcatgcttca gccttacatg 2280
cccacggtta gtgccacaat ccaggcccag ctgcagctcc cacctccagc ctgcagtatc 2340
ctgctgacaa acttcctgtg taccttacca gcaggacacc agattggcac agcaaaaacg 2400
tccccgaagc cagcagttgt agagactgtt acaacagcca agccacagca gatacaagcg 2460
ctgatggatg aagtgacaaa acaaggaaac attgtccgag aactgaaagc acaaaaggca 2520
gacaagaacg aggttgctgc ggaggtggcg aaactcttgg atctaaagaa acagttggct 2580
gtagctgagg ggaaaccccc tgaagcccct aaaggcaaga agaaaaagta a          2631

<210> 40
<211> 50
<212> DNA
<213> Homo sapiens

<400> 40
tcttctccac tagtgcaatc tgccggtatt ctatgtctgg tttgatgcca            50

<210> 41
<211> 16
<212> PRT
<213> Homo sapiens

<400> 41
Phe Ser Thr Ser Ala Ile Cys Arg Tyr Ser Met Ser Gly Leu Met Pro
 1               5                  10                  15      


<210> 42
<211> 50
<212> DNA
<213> Homo sapiens

<400> 42
gcaccaccac tccacagcag accaaaagcc tcagtgtaaa gtctgccgat            50

<210> 43
<211> 16
<212> PRT
<213> Homo sapiens

<400> 43
Thr Thr Thr Pro Gln Gln Thr Lys Ser Leu Ser Val Lys Ser Ala Asp
 1               5                  10                  15      


<210> 44
<211> 50
<212> DNA
<213> Homo sapiens

<400> 44
acccttagaa ggttttgaag acaaggtgga cctgtatcag ttcatggcca            50

<210> 45
<211> 16
<212> PRT
<213> Homo sapiens

<400> 45
Pro Leu Glu Gly Phe Glu Asp Lys Val Asp Leu Tyr Gln Phe Met Ala
 1               5                  10                  15      


<210> 46
<211> 50
<212> DNA
<213> Homo sapiens

<400> 46
gagatggtgg aagaacccag agcaaagtac ctgaactatg aggatgggaa            50

<210> 47
<211> 10
<212> PRT
<213> Homo sapiens

<400> 47
Arg Trp Trp Lys Asn Pro Glu Gln Ser Thr
 1               5                  10  


<210> 48
<211> 50
<212> DNA
<213> Homo sapiens

<400> 48
ggattaaagg cagtgaggct gacaggtcag tcccttgttc caaaaattgg            50

<210> 49
<211> 16
<212> PRT
<213> Homo sapiens

<400> 49
Ile Lys Gly Ser Glu Ala Asp Arg Ser Val Pro Cys Ser Lys Asn Trp
 1               5                  10                  15      


<210> 50
<211> 50
<212> DNA
<213> Homo sapiens

<400> 50
aaggcagcgc tttggagggg gccagggaaa cattgtccga gaactgaaag            50

<210> 51
<211> 16
<212> PRT
<213> Homo sapiens

<400> 51
Arg Gln Arg Phe Gly Gly Gly Gln Gly Asn Ile Val Arg Glu Leu Lys
 1               5                  10                  15      


<210> 52
<211> 50
<212> DNA
<213> Homo sapiens

<400> 52
tcttctccac tagtgcaatc tgccgaggag ctgagtgccc tgcacagctg            50

<210> 53
<211> 16
<212> PRT
<213> Homo sapiens

<400> 53
Phe Ser Thr Ser Ala Ile Cys Arg Gly Ala Glu Cys Pro Ala Gln Leu
 1               5                  10                  15      


<210> 54
<211> 50
<212> DNA
<213> Homo sapiens

<400> 54
aagggctgtc accaatgagc ctgaggttgc ctgtggctgg agaaaggaat            50

<210> 55
<211> 16
<212> PRT
<213> Homo sapiens

<400> 55
Arg Ala Val Thr Asn Glu Pro Glu Val Ala Cys Gly Trp Arg Lys Glu
 1               5                  10                  15      


<210> 56
<211> 50
<212> DNA
<213> Homo sapiens

<400> 56
cgctgcggcc ccagcagaat ccagtgtgga cctgtatcag ttcatggcca            50

<210> 57
<211> 16
<212> PRT
<213> Homo sapiens

<400> 57
Leu Arg Pro Gln Gln Asn Pro Val Trp Thr Cys Ile Ser Ser Trp Pro
 1               5                  10                  15      


<210> 58
<211> 50
<212> DNA
<213> Homo sapiens

<400> 58
accagcagga caccagattg gcacagcaaa aacgtccccg aagccagcag            50

<210> 59
<211> 16
<212> PRT
<213> Homo sapiens

<400> 59
Pro Ala Gly His Gln Ile Gly Thr Ala Lys Thr Ser Pro Lys Pro Ala
 1               5                  10                  15      


<210> 60
<211> 263
<212> PRT
<213> Homo sapiens

<400> 60
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu
            260             


<210> 61
<211> 789
<212> DNA
<213> Homo sapiens

<400> 61
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaa                                                         789

<210> 62
<211> 197
<212> PRT
<213> Homo sapiens

<400> 62
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala
        195         


<210> 63
<211> 591
<212> DNA
<213> Homo sapiens

<400> 63
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc t          591

<210> 64
<211> 214
<212> PRT
<213> Homo sapiens

<400> 64
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg
    210                 


<210> 65
<211> 642
<212> DNA
<213> Homo sapiens

<400> 65
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gg                    642

<210> 66
<211> 221
<212> PRT
<213> Homo sapiens

<400> 66
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu
    210                 215                 220     


<210> 67
<211> 663
<212> DNA
<213> Homo sapiens

<400> 67
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gag                                                               663

<210> 68
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 68
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu Glu
                245                 250     


<210> 69
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 69
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu
225                 230                 235                 240 
Gly Leu Asp Ser Thr His His His His His His
                245                 250     


<210> 70
<211> 283
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 70
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala
                245                 250                 255     
Val Thr Ala Trp Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro
            260                 265                 270         
Gln Gln Asn Pro Val Leu Pro Val Ala Gly Glu
        275                 280             


<210> 71
<211> 283
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 71
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu
            260                 265                 270         
Gly Leu Asp Ser Thr His His His His His His
        275                 280             


<210> 72
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 72
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Ser Met Ser Gly Leu Met Pro Leu
                85                  90                  95      
Leu Ala Ile Cys Pro Ser Gln Pro Thr Thr Gln Thr Ser Gly Arg Asp
            100                 105                 110         
Gly Gly Arg Thr Gln Ser Lys Trp Thr Cys Ile Ser Ser Trp Pro Lys
        115                 120                 125             
Thr Met Phe Leu Ser Ile Ala
    130                 135 


<210> 73
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 73
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Ser Met Ser Gly Leu Met Pro Leu Leu Ala Ile Cys
65                  70                  75                  80  
Pro Ser Gln Pro Thr Thr Gln Thr Ser Gly Arg Asp Gly Gly Arg Thr
                85                  90                  95      
Gln Ser Lys Trp Thr Cys Ile Ser Ser Trp Pro Lys Thr Met Phe Leu
            100                 105                 110         
Ser Ile Ala Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
        115                 120                 125             
Thr His His His His His His
    130                 135 


<210> 74
<211> 447
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 74
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala
                245                 250                 255     
Val Thr Ala Trp Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro
            260                 265                 270         
Gln Gln Asn Pro Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile
        275                 280                 285             
Thr Ser Ala Leu Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile
    290                 295                 300                 
Ile Gly Cys Val Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu
305                 310                 315                 320 
Arg Gln Trp Asn Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr
                325                 330                 335     
Ala Thr Glu Thr Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile
            340                 345                 350         
Cys Asp Lys Tyr His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn
        355                 360                 365             
Ile Ser Phe Asp Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys
    370                 375                 380                 
Ser Leu Ser Val Lys Ser Ala Asp His Ala Leu Trp Cys Ser Arg Ala
385                 390                 395                 400 
Ser Thr Cys Phe Trp Thr Cys Leu Ser Trp Arg Ser Asp Trp Arg Ser
                405                 410                 415     
Gly Trp Gly Gly His Cys Leu Ala Val Thr Gly His Pro Met Pro Ser
            420                 425                 430         
Leu Ser Pro Val Leu Gly Phe Gly Met Ala Ser Ser His Ala Ala
        435                 440                 445         


<210> 75
<211> 447
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 75
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ser Leu Ser Val
        355                 360                 365             
Lys Ser Ala Asp His Ala Leu Trp Cys Ser Arg Ala Ser Thr Cys Phe
    370                 375                 380                 
Trp Thr Cys Leu Ser Trp Arg Ser Asp Trp Arg Ser Gly Trp Gly Gly
385                 390                 395                 400 
His Cys Leu Ala Val Thr Gly His Pro Met Pro Ser Leu Ser Pro Val
                405                 410                 415     
Leu Gly Phe Gly Met Ala Ser Ser His Ala Ala Gly Lys Pro Ile Pro
            420                 425                 430         
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
        435                 440                 445         


<210> 76
<211> 567
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 76
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala
                245                 250                 255     
Val Thr Ala Trp Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro
            260                 265                 270         
Gln Gln Asn Pro Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile
        275                 280                 285             
Thr Ser Ala Leu Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile
    290                 295                 300                 
Ile Gly Cys Val Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu
305                 310                 315                 320 
Arg Gln Trp Asn Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr
                325                 330                 335     
Ala Thr Glu Thr Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile
            340                 345                 350         
Cys Asp Lys Tyr His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn
        355                 360                 365             
Ile Ser Phe Asp Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys
    370                 375                 380                 
Ile Thr Gln Asp Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu
385                 390                 395                 400 
Gln Asp Thr Val Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu
                405                 410                 415     
Ala Asp Arg Phe Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu
            420                 425                 430         
Ala Arg Gly Asp Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val
        435                 440                 445             
Glu Leu Lys Lys Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val
    450                 455                 460                 
Gln Ser Ser Gln His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg
465                 470                 475                 480 
Leu Glu Glu Trp Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro
                485                 490                 495     
Asn Ala Gln Phe Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro
            500                 505                 510         
Arg Cys Ile Thr Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu
        515                 520                 525             
Gly Phe Glu Asp Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly
    530                 535                 540                 
Tyr Leu Ser Ile Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp
545                 550                 555                 560 
Lys Asn Pro Glu Gln Ser Thr
                565         


<210> 77
<211> 567
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 77
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430         
Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445             
His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460                 
Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 
Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495     
Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510         
Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile
        515                 520                 525             
Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu
    530                 535                 540                 
Gln Ser Thr Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
545                 550                 555                 560 
Thr His His His His His His
                565         


<210> 78
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 78
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala
    210                 215         


<210> 79
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 79
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
        195                 200                 205             
Asp Ser Thr His His His His His His
    210                 215         


<210> 80
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 80
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg
225                 230                 


<210> 81
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 81
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
    210                 215                 220                 
Leu Asp Ser Thr His His His His His His
225                 230                 


<210> 82
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 82
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu
    


<210> 83
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 83
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Gly Lys Pro
    210                 215                 220                 
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
225                 230                 235                 240 
His
    


<210> 84
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 84
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Gly Ala Glu Cys Pro Ala Gln Leu Val
                85                  90                  95      
Pro Asp Thr Glu Tyr Pro Gly Thr Met Ser Ala Ser Cys Arg Asp Cys
            100                 105                 110         
Thr Glu Thr Ala Arg Cys Pro Gly Ser Pro Ala Leu Pro Pro Lys Ala
        115                 120                 125             
Ala Pro Ala Gln Pro Arg
    130                 


<210> 85
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 85
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Gly Ala Glu Cys Pro Ala Gln Leu Val Pro Asp Thr Glu
65                  70                  75                  80  
Tyr Pro Gly Thr Met Ser Ala Ser Cys Arg Asp Cys Thr Glu Thr Ala
                85                  90                  95      
Arg Cys Pro Gly Ser Pro Ala Leu Pro Pro Lys Ala Ala Pro Ala Gln
            100                 105                 110         
Pro Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
        115                 120                 125             
His His His His His His
    130                 


<210> 86
<211> 296
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 86
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu Val Ala Cys Gly Trp Arg Lys Glu Cys Ala His His Gln Cys Pro
                245                 250                 255     
Pro Leu Arg Gln Gln Cys Pro Pro Pro Trp Glu His His Trp Leu Cys
            260                 265                 270         
Ala Gln Cys Arg Cys Leu Cys Gln Val Leu Ser Pro Pro Pro Val Glu
        275                 280                 285             
His Pro Leu Ser Val Trp Asp Arg
    290                 295     


<210> 87
<211> 296
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 87
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Val Ala Cys
    210                 215                 220                 
Gly Trp Arg Lys Glu Cys Ala His His Gln Cys Pro Pro Leu Arg Gln
225                 230                 235                 240 
Gln Cys Pro Pro Pro Trp Glu His His Trp Leu Cys Ala Gln Cys Arg
                245                 250                 255     
Cys Leu Cys Gln Val Leu Ser Pro Pro Pro Val Glu His Pro Leu Ser
            260                 265                 270         
Val Trp Asp Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
        275                 280                 285             
Ser Thr His His His His His His
    290                 295     


<210> 88
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 88
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys
            20                  25                  30          
Leu Pro Val Leu Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val
        35                  40                  45              
Leu Ile Ser Thr Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr
    50                  55                  60                  
Arg Pro Lys Val Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe
65                  70                  75                  80  
Ser Thr Ser Ala Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu
                85                  90                  95      
Gln Asp Asp Leu Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu
            100                 105                 110         
Gln Pro Ala Leu Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys
        115                 120                 125             
Lys Gly Glu Asp Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile
    130                 135                 140                 
Asp His Ser Leu Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr
145                 150                 155                 160 
Glu Ser Leu Ala Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu
                165                 170                 175     
Gln Asp Pro Ala Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp
            180                 185                 190         
Phe Gln Thr Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr
        195                 200                 205             
Val Leu Lys Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys
    210                 215                 220                 
Gln Pro Gln Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro
225                 230                 235                 240 
Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala
                245                 250                 255     
Val Thr Ala Trp Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro
            260                 265                 270         
Gln Gln Asn Pro Val Trp Thr Cys Ile Ser Ser Trp Pro Lys Thr Met
        275                 280                 285             
Phe Leu Ser Ile Ala
    290             


<210> 89
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 89
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Trp Thr Cys Ile Ser Ser Trp Pro Lys Thr Met Phe Leu Ser Ile
            260                 265                 270         
Ala Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
        275                 280                 285             
His His His His His
    290             


<210> 90
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 90
cgcttattcg tgtccgacgg cgtcccaggc tgcttaccag tgctggcggc ggctggccgc 60
gcacgtggtc gcgcggaggt cctgatcagc accgttggcc cggaggactg tgtggttccg 120
tttctgaccc gcccgaaggt cccggtgctg caattggact cgggcaacta cctgtttagc 180
acctccgcga tttgccgcta cttcttcctg ctgagcggtt gggaacaaga cgatctgacc 240
aatcaatggc tggagtggga ggccaccgag ctgcagccgg cactgtctgc agcgttgtac 300
tatctggtcg tgcaaggtaa gaaaggcgaa gatgtgctgg gtagcgtccg tcgtgccttg 360
acgcatatcg accacagcct gtcccgtcaa aattgtccgt tcctggctgg tgaaaccgag 420
agcttggcgg atattgttct gtggggcgcg ctgtatcctc tgctgcagga tccagcctat 480
ctgccggaag agttgtctgc cctgcacagc tggtttcaaa cgctgagcac ccaggaaccg 540
tgccagcgtg ccgcagaaac tgttctgaaa cagcaaggtg ttctggcact gcgtccgtac 600
ctgcagaaac agcctcagcc gagcccagct gagggtcgtg cggtgacgaa cgagccggaa 660
gaagaagagc tggcgacgct gagcgaagag taatgactcg ag                    702

<210> 91
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 91
cgcttattcg tgtccgacgg cgtcccaggc tgcttaccag tgttggcggc tgcaggtcgt 60
gcgcgcggtc gcgccgaggt cctgattagc accgtgggtc cggaagattg tgtggtccct 120
ttcctgaccc gtccgaaagt tccggtcctg cagctggatt ccggcaatta cttgtttagc 180
accagcgcaa tttgtcgcta cttctttctg ctgagcggtt gggagcaaga tgacctgacg 240
aaccagtggc tggagtggga ggccacggag ctgcagccgg cgctgagcgc agccctgtat 300
tacttggttg tgcagggtaa gaaaggcgag gacgtgctgg gcagcgttcg tcgtgcgctg 360
acccacatcg accattctct gagccgtcaa aattgcccgt ttctggcggg tgagactgag 420
agcctggcag acatcgtgct gtggggcgcg ttgtatccac tgctgcaaga tccggcttac 480
ctgccggaag agctgagcgc cctgcactcg tggttccaaa cgctgtctac tcaggaaccg 540
tgccaacgtg ctgccgaaac cgttctgaag caacagggtg ttctggcgct gcgcccgtat 600
ttgcagaaac agccacaacc gagcccggca gaaggccgtg cggtcaccaa cgagccggaa 660
gaagaagagc tggcgaccct gtctgaagaa gaaatcgcga tggcagttac ggcgtgggag 720
aagggtctgg agagcctgcc gccgttgcgt ccacagcaaa acccggtgct gccggtcgca 780
ggtgagtaat gactcgag                                               798

<210> 92
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 92
agattattcg ttagcgacgg cgtcccaggc tgcctcccag tactggcggc agcgggccgc 60
gcccgtggcc gcgccgaggt gttgatttct acggttggcc cagaagattg cgttgtcccg 120
tttctgacgc gtccgaaggt gcctgtcctg cagctggaca gcggtaacta cctgttcagc 180
acctccgcta tctgccgtta tagcatgagc ggtctgatgc cgctgctggc aatctgtccg 240
agccaaccga ccacccaaac gtcgggtcgt gacggtggtc gcacccagtc caagtggact 300
tgtattagca gctggccgaa aaccatgttc ctgagcatcg cgtaatgact cgag       354

<210> 93
<211> 1290
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 93
agattattcg tcagcgacgg cgtcccaggc tgcctcccag tgctggcggc agcaggccgc 60
gctcgcggcc gtgcggaggt gctgattagc accgttggcc cggaggattg cgtggtcccg 120
ttcctgaccc gtccgaaagt gccggtgctg cagctggaca gcggtaacta cctgtttagc 180
acgtccgcga tctgtcgcta tttcttcctg ctgagcggtt gggagcaaga cgacctgacc 240
aatcagtggc tggagtggga ggcgaccgag ctgcaaccgg cgctgagcgc agctctgtac 300
tatttggttg tgcaaggtaa gaaaggtgag gatgtgctgg gcagcgtccg tcgtgccttg 360
acccatatcg accatagcct gagccgccag aattgtccgt ttctggcggg tgaaaccgag 420
tccctggcgg atatcgtgct gtggggtgcg ctgtacccgc tgctgcagga cccggcgtac 480
ttgccggaag aactgtccgc tctgcactcc tggttccaaa ccttgagcac gcaagagccg 540
tgccaacgtg ccgcggagac tgtcctgaag caacaaggtg ttctggcact gcgtccgtac 600
ctgcagaaac agccgcagcc gagcccggcc gagggtcgtg ctgttaccaa tgagcctgaa 660
gaagaagagc tggcgacgct gagcgaagaa gaaattgcaa tggccgtgac tgcgtgggaa 720
aagggtctgg aatctctgcc gccactgcgc ccgcaacaaa accctgttct gccagtcgcc 780
ggtgagcgta acgttctgat taccagcgca ctgccgtatg tgaacaacgt tccgcacctg 840
ggcaacatta tcggttgtgt cctgagcgcc gatgttttcg cacgctatag ccgtctgcgt 900
cagtggaata cgctgtattt gtgcggtact gacgagtacg gtacggctac cgaaaccaaa 960
gcgctggaag agggtctgac gccgcaggag atctgcgata agtatcacat cattcatgcg 1020
gatatttacc gctggttcaa tatcagcttt gacattttcg gccgtacgac gacccctcag 1080
cagaccaaga gcctgagcgt caaatcggcc gaccacgcat tgtggtgtag ccgtgcatct 1140
acctgctttt ggacctgcct gtcgtggcgc agcgattggc gttctggttg gggcggtcat 1200
tgtctggcgg ttacgggcca cccaatgccg agcttgagcc cggtcttggg ctttggcatg 1260
gcgagctctc acgcggctta atgactcgag                                  1290

<210> 94
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 94
agattattcg tcagcgacgg cgtcccaggc tgcctcccag tgctggccgc ggcaggccgt 60
gcgcgcggtc gcgcagaagt tttgatcagc accgtcggtc cggaggactg cgtggttccg 120
ttcctgaccc gcccgaaagt cccagtgttg cagctggata gcggtaacta cctgtttagc 180
acgtccgcga tctgtcgtta tttcttcttg ctgagcggtt gggagcagga cgacctgacc 240
aatcaatggt tggagtggga ggcgaccgag ctgcagccgg ccctgtctgc ggcattgtac 300
tacctggttg tccagggtaa gaaaggcgaa gatgtgctgg gcagcgtccg ccgtgcgctg 360
acccacatcg atcactctct gtcgcgccaa aattgcccgt tcctggcggg tgaaacggag 420
agcctggcag acattgtgct gtggggtgct ttgtatccgc tgctgcaaga cccggcctat 480
ctgccggaag aactgagcgc tctgcacagc tggtttcaaa cgctgagcac gcaggaaccg 540
tgtcagcgtg cggcggagac tgttctgaag caacagggtg ttctggcgct gcgtccgtac 600
ctgcaaaagc aaccgcagcc gagccctgcg gagggtcgtg cagttacgaa cgaaccggaa 660
gaagaagagc tggcgaccct gagcgaagaa gagattgcaa tggcagtcac ggcgtgggaa 720
aagggtctgg agtcgttgcc gccgctgcgc ccacagcaaa atccggttct gccggtcgct 780
ggcgagcgta acgtgctgat taccagcgcc ctgccgtacg tgaacaacgt gccgcatctg 840
ggtaacatca ttggctgcgt cctgagcgcg gatgtctttg cgcgttatag ccgcctgcgt 900
caatggaata ccctgtacct gtgcggtacc gacgagtatg gtaccgctac cgaaactaag 960
gcattggaag agggcctgac cccgcaggag atttgcgata aataccatat cattcatgcc 1020
gacatctacc gttggtttaa catcagcttc gatatctttg gccgcacgac cacgccgcaa 1080
caaaccaaaa ttacccaaga tattttccaa cagctgctga agcgcggctt tgttctgcag 1140
gacaccgttg agcagctgcg ttgcgagcac tgcgcacgtt ttctggccga ccgtttcgtg 1200
gagggtgtct gtccgttctg cggttatgaa gaagcccgtg gtgaccagtg tgacaaatgt 1260
ggcaaactga tcaatgctgt cgaactgaag aaacctcagt gcaaagtgtg tcgtagctgc 1320
cctgttgtgc aaagcagcca acacctgttc ctggatctgc caaagctgga gaagcgtctg 1380
gaagagtggc tgggccgtac cctgccgggc agcgattgga ccccgaatgc tcagttcatt 1440
acgcgctcct ggctgcgcga tggtctgaaa ccgcgttgta tcactcgtga cctgaaatgg 1500
ggtacgccgg ttccactgga gggctttgag gataaagtgt tctatgtgtg gtttgatgcg 1560
actattggtt acttgtccat caccgcgaat tacacggacc agtgggagcg ttggtggaag 1620
aacccggagc agtccaccta atgactcgag                                  1650

<210> 95
<211> 600
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 95
agattattcg tcagcgacgg cgtcccaggc tgcctcccag tgctggcggc cgcgggccgt 60
gcacgtggcc gtgcagaggt gttgattagc acggttggtc cggaagattg cgtcgttccg 120
tttctgacgc gtccgaaagt cccggtgctg caactggata gcggtaacta cctgttcagc 180
accagcgcaa tctgtcgcta tttctttctg ctgagcggct gggagcaaga cgacctgacc 240
aatcaatggt tggagtggga ggcgaccgaa ctgcaaccgg ccctgagcgc tgcgctgtat 300
tacttggtgg tgcagggtaa gaaaggtgag gatgtcctgg gttccgttcg tcgcgcgttg 360
acccacatcg atcacagcct gtcgcgtcaa aactgtccgt tcctggcagg tgaaaccgag 420
tctctggccg acattgtcct gtggggcgcg ctgtatccgc tgctgcagga cccggcatac 480
ctgcctgaag aactgagcgc gctgcattct tggtttcaga cgctgagcac ccaggagcca 540
tgccagcgcg cggctgaaac tgttctgaag caacagggtg tgttggccta atgactcgag 600


<210> 96
<211> 651
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 96
agattattcg ttagcgacgg cgtcccaggc tgcctcccag tactggcagc ggccggtcgt 60
gcgcgcggcc gtgcggaggt gttgatcagc accgttggcc cggaggattg cgtggtccct 120
ttcctgactc gtccgaaagt cccggtcctg cagttggact cgggcaatta cctgtttagc 180
accagcgcca tttgccgtta cttctttctg ctgagcggtt gggagcaaga cgatctgacg 240
aaccaatggc tggagtggga agcaaccgag ctgcaaccgg ctctgtccgc tgcgctgtac 300
tatctggtcg ttcagggtaa gaagggtgag gacgttctgg gctccgttcg tcgtgcgctg 360
acgcatatcg atcacagcct gagccgtcaa aactgtccgt tcctggcggg tgaaacggaa 420
agcctggccg acattgttct gtggggtgcg ttgtacccgt tgctgcagga tccggcatat 480
ttgccggaag aactgagcgc actgcactcg tggtttcaga ccctgagcac gcaagagccg 540
tgtcaacgcg ctgcggaaac cgtgctgaaa cagcagggtg tgctggcact gcgcccttat 600
ctgcagaaac agccgcaacc atctccggcg gagggccgct aatgactcga g          651

<210> 97
<211> 672
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 97
agattattcg ttagcgacgg cgtcccaggc tgccttccag tattggcggc ggcgggtcgc 60
gcgcgtggcc gtgctgaagt gctgattagc accgtgggtc ctgaggactg tgttgtgccg 120
ttcttgaccc gtccgaaagt tccggtgttg cagctggata gcggcaatta cctgtttagc 180
acctccgcaa tctgccgtta cttcttcctg ctgtctggtt gggagcaaga tgacttgacc 240
aatcagtggc tggaatggga ggcaacggag ctgcaacctg ccctgagcgc agcgctgtat 300
tatctggtcg tgcagggtaa gaaaggcgag gatgttctgg gtagcgtccg tcgcgccctg 360
acgcacatcg accattcgct gtcccgccaa aactgtccgt ttctggcggg cgagactgag 420
agcctggcag acattgtcct gtggggtgcc ctgtacccgt tgctgcagga tccggcgtat 480
ctgccggaag aactgagcgc gctgcactct tggtttcaga ccctgagcac ccaagaacca 540
tgccagcgtg ctgctgaaac ggttctgaag caacaaggcg tcctggcgct gcgtccgtac 600
ctgcagaaac agccgcaacc gagcccggcc gagggtcgcg cagttacgaa cgaaccggag 660
taatgactcg ag                                                     672

<210> 98
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 98
agattattcg tcagcgacgg cgtcccaggc tgcctcccag tactggcggc tgccggtcgc 60
gcacgtggtc gcgcagaagt tctgatttcc accgtcggcc cagaggattg tgtcgtgccg 120
ttcctgaccc gtcctaaagt gccggtgctg cagctggaca gcggcaacta cttgtttagc 180
acctctgcga tctgccgtgg cgcggagtgc ccggcacaac tggttccgga caccgagtat 240
ccgggtacta tgtcggcgag ctgccgtgat tgtacggaaa cggcccgttg tccgggtagc 300
ccggctctgc cgcctaaggc ggcgccggca cagccgcgct aatgactcga g          351

<210> 99
<211> 837
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 99
agattattcg tcagcgacgg cgtcccaggc tgcctcccag tactggccgc ggcgggtcgt 60
gcacgtggcc gcgctgaggt tttgatctcc accgtgggtc ctgaggattg tgtcgtgcct 120
tttctgacgc gcccgaaggt tccggttctg cagttggata gcggcaatta tttgttcagc 180
accagcgcaa tttgccgtta tttcttcttg ctgtctggtt gggagcagga cgatctgacc 240
aatcagtggc tggagtggga agccaccgag ttgcaaccgg ccctgagcgc tgcgctgtat 300
tacctggtgg tccaaggtaa gaaaggtgag gacgttctgg gtagcgtccg tcgtgcactg 360
acgcatatcg accacagcct gtctcgtcaa aactgtccgt ttctggcggg cgaaacggag 420
agcctggcag acattgttct gtggggcgcg ctgtacccgc tgctgcaaga cccggcgtac 480
ctgccggaag aactgtccgc cctgcatagc tggtttcaga ccctgagcac gcaggaaccg 540
tgccagcgcg cggcagagac tgtgctgaag caacaaggtg tcctggcgct gcgcccttac 600
ctgcagaaac aaccgcagcc gagcccggcc gagggtcgtg ctgtgaccaa cgaaccagaa 660
gttgcgtgcg gctggcgtaa agaatgcgcg caccatcaat gcccgccgct gcgtcagcaa 720
tgccctccgc cgtgggagca ccactggctg tgtgctcagt gccgctgtct gtgtcaggtc 780
ctgtcgccgc cgccggtcga gcacccgttg agcgtgtggg atcgttaatg actcgag    837

<210> 100
<211> 828
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 100
agattattcg tcagcgacgg cgtcccaggc tgcctcccag tactggcagc cgccggtcgc 60
gcgcgtggtc gtgcggaggt tctgattagc accgtgggcc cggaggactg tgtggttccg 120
ttcctgacgc gtccgaaagt tcctgtgctg cagctggata gcggcaacta tttgtttagc 180
accagcgcga tttgccgtta cttctttctg ctgtccggtt gggagcaaga cgatttgacg 240
aatcaatggc tggagtggga agcaactgag ctgcaaccag cgctgtcggc ggcgctgtac 300
tatttggtcg ttcagggtaa gaaaggtgag gatgtcctgg gtagcgtccg ccgtgcactg 360
actcacatcg accacagctt gtctcgtcag aactgcccgt tcctggcagg tgaaacggag 420
tccctggccg acatcgtgct gtggggcgcg ctgtacccgt tgctgcagga tccggcgtac 480
ctgccggaag agctgagcgc cctgcatagc tggtttcaga ccctgagcac ccaagagccg 540
tgccaacgtg cagcagaaac ggtcctgaag cagcaaggcg ttctggcgct gcgcccgtat 600
ctgcaaaagc agccgcagcc gtccccagcc gaaggccgcg ctgtcaccaa tgagccggaa 660
gaagaagagc tggctacgct gagcgaagaa gaaattgcta tggccgtgac cgcgtgggag 720
aaaggtctgg agagcttgcc gccgctgcgt cctcaacaga acccggtttg gacctgtatc 780
tctagctggc cgaaaaccat gttcctgagc atcgcgtaat gactcgag              828

<210> 101
<211> 707
<212> PRT
<213> Homo sapiens

<400> 101
Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro Ser
 1               5                  10                  15      
Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu Leu
            20                  25                  30          
Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp Glu
        35                  40                  45              
Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro Val
    50                  55                  60                  
Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu Pro
65                  70                  75                  80  
Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val Leu
                85                  90                  95      
Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn Thr
            100                 105                 110         
Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr Lys
        115                 120                 125             
Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr His
    130                 135                 140                 
Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp Ile
145                 150                 155                 160 
Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp Ile
                165                 170                 175     
Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val Glu
            180                 185                 190         
Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe Val
        195                 200                 205             
Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp Gln
    210                 215                 220                 
Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys Pro
225                 230                 235                 240 
Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln His
                245                 250                 255     
Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp Leu
            260                 265                 270         
Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe Ile
        275                 280                 285             
Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr Arg
    290                 295                 300                 
Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp Lys
305                 310                 315                 320 
Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile Thr
                325                 330                 335     
Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu Gln
            340                 345                 350         
Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His Ser
        355                 360                 365             
Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr Leu
    370                 375                 380                 
Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys
385                 390                 395                 400 
Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln Asp
                405                 410                 415     
Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg
            420                 425                 430         
Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys
        435                 440                 445             
Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala
    450                 455                 460                 
Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met Val
465                 470                 475                 480 
Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu Leu
                485                 490                 495     
Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala Leu
            500                 505                 510         
Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln Val
        515                 520                 525             
Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg
    530                 535                 540                 
Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu Ser
545                 550                 555                 560 
Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln Ala
                565                 570                 575     
Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe
            580                 585                 590         
Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu
        595                 600                 605             
Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe
    610                 615                 620                 
Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr
625                 630                 635                 640 
Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val
                645                 650                 655     
Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp
            660                 665                 670         
Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys
        675                 680                 685             
Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys
    690                 695                 700                 
Lys Lys Lys
705         


<210> 102
<211> 2124
<212> DNA
<213> Homo sapiens

<400> 102
ggtgtcctgg ctctccggcc ttacctccaa aagcagcccc agcccagccc cgctgaggga 60
agggctgtca ccaatgagcc tgaggaggag gagctggcta ccctatctga ggaggagatt 120
gctatggctg ttactgcttg ggagaagggc ctagaaagtt tgcccccgct gcggccccag 180
cagaatccag tgttgcctgt ggctggagaa aggaatgtgc tcatcaccag tgccctccct 240
tacgtcaaca atgtccccca ccttgggaac atcattggtt gtgtgctcag tgccgatgtc 300
tttgccaggt actctcgcct ccgccagtgg aacaccctct atctgtgtgg gacagatgag 360
tatggtacag caacagagac caaggctctg gaggagggac taacccccca ggagatctgc 420
gacaagtacc acatcatcca tgctgacatc taccgctggt ttaacatttc gtttgatatt 480
tttggtcgca ccaccactcc acagcagacc aaaatcaccc aggacatttt ccagcagttg 540
ctgaaacgag gttttgtgct gcaagatact gtggagcaac tgcgatgtga gcactgtgct 600
cgcttcctgg ctgaccgctt cgtggagggc gtgtgtccct tctgtggcta tgaggaggct 660
cggggtgacc agtgtgacaa gtgtggcaag ctcatcaatg ctgtcgagct taagaagcct 720
cagtgtaaag tctgccgatc atgccctgtg gtgcagtcga gccagcacct gtttctggac 780
ctgcctaagc tggagaagcg actggaggag tggttgggga ggacattgcc tggcagtgac 840
tggacaccca atgcccagtt tatcacccgt tcttggcttc gggatggcct caagccacgc 900
tgcataaccc gagacctcaa atggggaacc cctgtaccct tagaaggttt tgaagacaag 960
gtattctatg tctggtttga tgccactatt ggctatctgt ccatcacagc caactacaca 1020
gaccagtggg agagatggtg gaagaaccca gagcaagtgg acctgtatca gttcatggcc 1080
aaagacaatg ttcctttcca tagcttagtc tttccttgct cagccctagg agctgaggat 1140
aactatacct tggtcagcca cctcattgct acagagtacc tgaactatga ggatgggaaa 1200
ttctctaaga gccgcggtgt gggagtgttt ggggacatgg cccaggacac ggggatccct 1260
gctgacatct ggcgcttcta tctgctgtac attcggcctg agggccagga cagtgctttc 1320
tcctggacgg acctgctgct gaagaataat tctgagctgc ttaacaacct gggcaacttc 1380
atcaacagag ctgggatgtt tgtgtctaag ttctttgggg gctatgtgcc tgagatggtg 1440
ctcacccctg atgatcagcg cctgctggcc catgtcaccc tggagctcca gcactatcac 1500
cagctacttg agaaggttcg gatccgggat gccttgcgca gtatcctcac catatctcga 1560
catggcaacc aatatattca ggtgaatgag ccctggaagc ggattaaagg cagtgaggct 1620
gacaggcaac gggcaggaac agtgactggc ttggcagtga atatagctgc cttgctctct 1680
gtcatgcttc agccttacat gcccacggtt agtgccacaa tccaggccca gctgcagctc 1740
ccacctccag cctgcagtat cctgctgaca aacttcctgt gtaccttacc agcaggacac 1800
cagattggca cagtcagtcc cttgttccaa aaattggaaa atgaccagat tgaaagttta 1860
aggcagcgct ttggaggggg ccaggcaaaa acgtccccga agccagcagt tgtagagact 1920
gttacaacag ccaagccaca gcagatacaa gcgctgatgg atgaagtgac aaaacaagga 1980
aacattgtcc gagaactgaa agcacaaaag gcagacaaga acgaggttgc tgcggaggtg 2040
gcgaaactct tggatctaaa gaaacagttg gctgtagctg aggggaaacc ccctgaagcc 2100
cctaaaggca agaagaaaaa gtaa                                        2124

<210> 103
<211> 28
<212> PRT
<213> Mus musculus

<400> 103
Thr Val Ser Asn Glu Leu Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu
 1               5                  10                  15      
Glu Asp Ile Val Thr Ala Val Ala Ala Trp Glu Lys
            20                  25              


<210> 104
<211> 22
<212> PRT
<213> Mus musculus

<400> 104
Gly Leu Glu Ser Leu Pro Pro Leu Lys Leu Gln Gln His Pro Val Leu
 1               5                  10                  15      
Pro Val Pro Gly Glu Arg
            20          


<210> 105
<211> 10
<212> PRT
<213> Mus musculus

<400> 105
Asn Val Leu Ile Thr Ser Ala Leu Pro Tyr
 1               5                  10  


<210> 106
<211> 22
<212> PRT
<213> Mus musculus

<400> 106
Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val Leu Ser
 1               5                  10                  15      
Ala Asp Val Phe Ala Arg
            20          


<210> 107
<211> 3
<212> PRT
<213> Mus musculus

<400> 107
Tyr Cys Arg
 1          


<210> 108
<211> 22
<212> PRT
<213> Mus musculus

<400> 108
Leu Arg Gln Trp Asn Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly
 1               5                  10                  15      
Thr Ala Thr Glu Thr Lys
            20          


<210> 109
<211> 9
<212> PRT
<213> Mus musculus

<400> 109
Ala Met Glu Glu Gly Leu Thr Pro Arg
 1               5                  


<210> 110
<211> 15
<212> PRT
<213> Mus musculus

<400> 110
Glu Ile Cys Asp Lys Tyr His Ala Ile His Ala Asp Ile Tyr Arg
 1               5                  10                  15  


<210> 111
<211> 11
<212> PRT
<213> Mus musculus

<400> 111
Trp Phe Gly Ile Ser Phe Asp Thr Phe Gly Arg
 1               5                  10      


<210> 112
<211> 8
<212> PRT
<213> Mus musculus

<400> 112
Thr Thr Thr Pro Gln Gln Thr Lys
 1               5              


<210> 113
<211> 8
<212> PRT
<213> Mus musculus

<400> 113
Ile Thr Gln Asp Ile Phe Gln Arg
 1               5              


<210> 114
<211> 27
<212> PRT
<213> Mus musculus

<400> 114
Leu Leu Thr Arg Gly Phe Val Leu Arg Asp Thr Val Glu Gln Leu Arg
 1               5                  10                  15      
Cys Glu Arg Cys Ala Arg Phe Leu Ala Asp Arg
            20                  25          


<210> 115
<211> 15
<212> PRT
<213> Mus musculus

<400> 115
Phe Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg
 1               5                  10                  15  


<210> 116
<211> 31
<212> PRT
<213> Mus musculus

<400> 116
Gly Asp Gln Cys Asp Arg Cys Gly Lys Leu Ile Asn Ala Ile Glu Leu
 1               5                  10                  15      
Lys Lys Pro Gln Cys Lys Ile Cys Arg Ser Cys Pro Val Val Arg
            20                  25                  30      


<210> 117
<211> 11
<212> PRT
<213> Mus musculus

<400> 117
Ser Ser Gln His Leu Phe Leu Asp Leu Pro Lys
 1               5                  10      


<210> 118
<211> 98
<212> PRT
<213> Mus musculus

<400> 118
Leu Glu Lys Arg Leu Glu Asp Trp Leu Gly Lys Thr Val Pro Gly Ser
 1               5                  10                  15      
Asp Trp Thr Pro Asn Ala Arg Phe Ile Ile Arg Ser Trp Leu Arg Asp
            20                  25                  30          
Gly Leu Lys Pro Arg Cys Ile Thr Arg Asp Leu Lys Trp Gly Thr Pro
        35                  40                  45              
Val Pro Leu Glu Gly Phe Glu Asp Lys Val Phe Tyr Val Trp Phe Asp
    50                  55                  60                  
Ala Thr Ile Gly Tyr Val Ser Ile Thr Ala Asn Tyr Thr Asp Gln Trp
65                  70                  75                  80  
Glu Lys Trp Trp Lys Asn Pro Glu Gln Val Asp Leu Tyr Gln Phe Met
                85                  90                  95      
Ala Lys
        


<210> 119
<211> 25
<212> PRT
<213> Mus musculus

<400> 119
Asp Asn Val Pro Phe His Gly Leu Val Phe Pro Cys Ser Val Leu Gly
 1               5                  10                  15      
Ala Glu Asp Asn Tyr Thr Leu Val Lys
            20                  25  


<210> 120
<211> 14
<212> PRT
<213> Mus musculus

<400> 120
His Ile Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys
 1               5                  10                  


<210> 121
<211> 30
<212> PRT
<213> Mus musculus

<400> 121
Phe Ser Lys Ser Arg Gly Ile Gly Val Phe Gly Asp Met Ala Lys Asp
 1               5                  10                  15      
Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr
            20                  25                  30  


<210> 122
<211> 33
<212> PRT
<213> Mus musculus

<400> 122
Ile Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu
 1               5                  10                  15      
Ile Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn
            20                  25                  30          
Arg
    


<210> 123
<211> 57
<212> PRT
<213> Mus musculus

<400> 123
Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Cys Val Pro Glu Met
 1               5                  10                  15      
Ala Leu Thr Pro Asp Asp Arg Arg Leu Val Ala His Val Ser Trp Glu
            20                  25                  30          
Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala
        35                  40                  45              
Leu Arg Ser Ile Leu Thr Ile Ser Arg
    50                  55          


<210> 124
<211> 14
<212> PRT
<213> Mus musculus

<400> 124
His Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg
 1               5                  10                  


<210> 125
<211> 67
<212> PRT
<213> Mus musculus

<400> 125
Ile Lys Gly Gly Glu Met Asp Arg Gln Arg Ala Gly Thr Val Thr Gly
 1               5                  10                  15      
Met Ala Val Asn Met Ala Ala Leu Leu Ser Val Met Leu Gln Pro Tyr
            20                  25                  30          
Met Pro Thr Val Ser Ser Thr Ile Gln Thr Gln Leu Gln Leu Pro Pro
        35                  40                  45              
Ala Ala Cys Arg Ile Leu Ala Thr Ser Phe Ile Cys Thr Leu Pro Ala
    50                  55                  60                  
Gly His Arg
65          


<210> 126
<211> 10
<212> PRT
<213> Mus musculus

<400> 126
Ile Gly Thr Val Ser Pro Leu Phe Gln Lys
 1               5                  10  


<210> 127
<211> 10
<212> PRT
<213> Mus musculus

<400> 127
Leu Glu Asn Asp Gln Ile Glu Asn Leu Arg
 1               5                  10  


<210> 128
<211> 9
<212> PRT
<213> Mus musculus

<400> 128
Gln Arg Phe Gly Gly Gly Gln Ala Lys
 1               5                  


<210> 129
<211> 28
<212> PRT
<213> Mus musculus

<400> 129
Gly Ser Pro Lys Pro Ala Ala Val Glu Ala Val Thr Ala Ala Gly Ser
 1               5                  10                  15      
Gln His Ile Gln Thr Leu Thr Asp Glu Val Thr Lys
            20                  25              


<210> 130
<211> 30
<212> PRT
<213> Mus musculus

<400> 130
Gln Gly Asn Val Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn
 1               5                  10                  15      
Gln Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys
            20                  25                  30  


<210> 131
<211> 14
<212> PRT
<213> Mus musculus

<400> 131
Gln Leu Ala Leu Ala Glu Gly Lys Pro Ile Glu Thr Pro Lys
 1               5                  10                  


<210> 132
<211> 681
<212> PRT
<213> Mus musculus

<400> 132
Thr Val Ser Asn Glu Leu Glu Glu Glu Glu Leu Ala Thr Leu Ser Glu
 1               5                  10                  15      
Glu Asp Ile Val Thr Ala Val Ala Ala Trp Glu Lys Gly Leu Glu Ser
            20                  25                  30          
Leu Pro Pro Leu Lys Leu Gln Gln His Pro Val Leu Pro Val Pro Gly
        35                  40                  45              
Glu Arg Asn Val Leu Ile Thr Ser Ala Leu Pro Tyr Val Asn Asn Val
    50                  55                  60                  
Pro His Leu Gly Asn Ile Ile Gly Cys Val Leu Ser Ala Asp Val Phe
65                  70                  75                  80  
Ala Arg Tyr Cys Arg Leu Arg Gln Trp Asn Thr Leu Tyr Leu Cys Gly
                85                  90                  95      
Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr Lys Ala Met Glu Glu Gly
            100                 105                 110         
Leu Thr Pro Arg Glu Ile Cys Asp Lys Tyr His Ala Ile His Ala Asp
        115                 120                 125             
Ile Tyr Arg Trp Phe Gly Ile Ser Phe Asp Thr Phe Gly Arg Thr Thr
    130                 135                 140                 
Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp Ile Phe Gln Arg Leu Leu
145                 150                 155                 160 
Thr Arg Gly Phe Val Leu Arg Asp Thr Val Glu Gln Leu Arg Cys Glu
                165                 170                 175     
Arg Cys Ala Arg Phe Leu Ala Asp Arg Phe Val Glu Gly Val Cys Pro
            180                 185                 190         
Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp Gln Cys Asp Arg Cys Gly
        195                 200                 205             
Lys Leu Ile Asn Ala Ile Glu Leu Lys Lys Pro Gln Cys Lys Ile Cys
    210                 215                 220                 
Arg Ser Cys Pro Val Val Arg Ser Ser Gln His Leu Phe Leu Asp Leu
225                 230                 235                 240 
Pro Lys Leu Glu Lys Arg Leu Glu Asp Trp Leu Gly Lys Thr Val Pro
                245                 250                 255     
Gly Ser Asp Trp Thr Pro Asn Ala Arg Phe Ile Ile Arg Ser Trp Leu
            260                 265                 270         
Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr Arg Asp Leu Lys Trp Gly
        275                 280                 285             
Thr Pro Val Pro Leu Glu Gly Phe Glu Asp Lys Val Phe Tyr Val Trp
    290                 295                 300                 
Phe Asp Ala Thr Ile Gly Tyr Val Ser Ile Thr Ala Asn Tyr Thr Asp
305                 310                 315                 320 
Gln Trp Glu Lys Trp Trp Lys Asn Pro Glu Gln Val Asp Leu Tyr Gln
                325                 330                 335     
Phe Met Ala Lys Asp Asn Val Pro Phe His Gly Leu Val Phe Pro Cys
            340                 345                 350         
Ser Val Leu Gly Ala Glu Asp Asn Tyr Thr Leu Val Lys His Ile Ile
        355                 360                 365             
Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys Phe Ser Lys Ser Arg
    370                 375                 380                 
Gly Ile Gly Val Phe Gly Asp Met Ala Lys Asp Thr Gly Ile Pro Ala
385                 390                 395                 400 
Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg Pro Glu Gly Gln Asp
                405                 410                 415     
Ser Ala Phe Ser Trp Thr Asp Leu Leu Ile Lys Asn Asn Ser Glu Leu
            420                 425                 430         
Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala Gly Met Phe Val Ser
        435                 440                 445             
Lys Phe Phe Gly Gly Cys Val Pro Glu Met Ala Leu Thr Pro Asp Asp
    450                 455                 460                 
Arg Arg Leu Val Ala His Val Ser Trp Glu Leu Gln His Tyr His Gln
465                 470                 475                 480 
Leu Leu Glu Lys Val Arg Ile Arg Asp Ala Leu Arg Ser Ile Leu Thr
                485                 490                 495     
Ile Ser Arg His Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro Trp Lys
            500                 505                 510         
Arg Ile Lys Gly Gly Glu Met Asp Arg Gln Arg Ala Gly Thr Val Thr
        515                 520                 525             
Gly Met Ala Val Asn Met Ala Ala Leu Leu Ser Val Met Leu Gln Pro
    530                 535                 540                 
Tyr Met Pro Thr Val Ser Ser Thr Ile Gln Thr Gln Leu Gln Leu Pro
545                 550                 555                 560 
Pro Ala Ala Cys Arg Ile Leu Ala Thr Ser Phe Ile Cys Thr Leu Pro
                565                 570                 575     
Ala Gly His Arg Ile Gly Thr Val Ser Pro Leu Phe Gln Lys Leu Glu
            580                 585                 590         
Asn Asp Gln Ile Glu Asn Leu Arg Gln Arg Phe Gly Gly Gly Gln Ala
        595                 600                 605             
Lys Gly Ser Pro Lys Pro Ala Ala Val Glu Ala Val Thr Ala Ala Gly
    610                 615                 620                 
Ser Gln His Ile Gln Thr Leu Thr Asp Glu Val Thr Lys Gln Gly Asn
625                 630                 635                 640 
Val Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Gln Val Ala
                645                 650                 655     
Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Leu Ala
            660                 665                 670         
Glu Gly Lys Pro Ile Glu Thr Pro Lys
        675                 680     


<210> 133
<211> 349
<212> PRT
<213> Homo sapiens

<400> 133
Met Ala Lys Asp Asn Val Pro Phe His Ser Leu Val Phe Pro Cys Ser
 1               5                  10                  15      
Ala Leu Gly Ala Glu Asp Asn Tyr Thr Leu Val Ser His Leu Ile Ala
            20                  25                  30          
Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys Phe Ser Lys Ser Arg Gly
        35                  40                  45              
Val Gly Val Phe Gly Asp Met Ala Gln Asp Thr Gly Ile Pro Ala Asp
    50                  55                  60                  
Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg Pro Glu Gly Gln Asp Ser
65                  70                  75                  80  
Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys Asn Asn Ser Glu Leu Leu
                85                  90                  95      
Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala Gly Met Phe Val Ser Lys
            100                 105                 110         
Phe Phe Gly Gly Tyr Val Pro Glu Met Val Leu Thr Pro Asp Asp Gln
        115                 120                 125             
Arg Leu Leu Ala His Val Thr Leu Glu Leu Gln His Tyr His Gln Leu
    130                 135                 140                 
Leu Glu Lys Val Arg Ile Arg Asp Ala Leu Arg Ser Ile Leu Thr Ile
145                 150                 155                 160 
Ser Arg His Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg
                165                 170                 175     
Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg Ala Gly Thr Val Thr Gly
            180                 185                 190         
Leu Ala Val Asn Ile Ala Ala Leu Leu Ser Val Met Leu Gln Pro Tyr
        195                 200                 205             
Met Pro Thr Val Ser Ala Thr Ile Gln Ala Gln Leu Gln Leu Pro Pro
    210                 215                 220                 
Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys Thr Leu Pro Ala
225                 230                 235                 240 
Gly His Gln Ile Gly Thr Val Ser Pro Leu Phe Gln Lys Leu Glu Asn
                245                 250                 255     
Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly Gly Gln Ala Lys
            260                 265                 270         
Thr Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr Thr Ala Lys Pro
        275                 280                 285             
Gln Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys Gln Gly Asn Ile
    290                 295                 300                 
Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu Val Ala Ala
305                 310                 315                 320 
Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Val Ala Glu
                325                 330                 335     
Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
            340                 345                 


<210> 134
<211> 1050
<212> DNA
<213> Homo sapiens

<400> 134
atggccaaag acaatgttcc tttccatagc ttagtctttc cttgctcagc cctaggagct 60
gaggataact ataccttggt cagccacctc attgctacag agtacctgaa ctatgaggat 120
gggaaattct ctaagagccg cggtgtggga gtgtttgggg acatggccca ggacacgggg 180
atccctgctg acatctggcg cttctatctg ctgtacattc ggcctgaggg ccaggacagt 240
gctttctcct ggacggacct gctgctgaag aataattctg agctgcttaa caacctgggc 300
aacttcatca acagagctgg gatgtttgtg tctaagttct ttgggggcta tgtgcctgag 360
atggtgctca cccctgatga tcagcgcctg ctggcccatg tcaccctgga gctccagcac 420
tatcaccagc tacttgagaa ggttcggatc cgggatgcct tgcgcagtat cctcaccata 480
tctcgacatg gcaaccaata tattcaggtg aatgagccct ggaagcggat taaaggcagt 540
gaggctgaca ggcaacgggc aggaacagtg actggcttgg cagtgaatat agctgccttg 600
ctctctgtca tgcttcagcc ttacatgccc acggttagtg ccacaatcca ggcccagctg 660
cagctcccac ctccagcctg cagtatcctg ctgacaaact tcctgtgtac cttaccagca 720
ggacaccaga ttggcacagt cagtcccttg ttccaaaaat tggaaaatga ccagattgaa 780
agtttaaggc agcgctttgg agggggccag gcaaaaacgt ccccgaagcc agcagttgta 840
gagactgtta caacagccaa gccacagcag atacaagcgc tgatggatga agtgacaaaa 900
caaggaaaca ttgtccgaga actgaaagca caaaaggcag acaagaacga ggttgctgcg 960
gaggtggcga aactcttgga tctaaagaaa cagttggctg tagctgaggg gaaaccccct 1020
gaagccccta aaggcaagaa gaaaaagtaa                                  1050

<210> 135
<211> 323
<212> PRT
<213> Homo sapiens

<400> 135
Met Val Glu Glu Pro Arg Ala Lys Tyr Leu Asn Tyr Glu Asp Gly Lys
 1               5                  10                  15      
Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln Asp
            20                  25                  30          
Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg
        35                  40                  45              
Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys
    50                  55                  60                  
Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala
65                  70                  75                  80  
Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met Val
                85                  90                  95      
Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu Leu
            100                 105                 110         
Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala Leu
        115                 120                 125             
Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln Val
    130                 135                 140                 
Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg
145                 150                 155                 160 
Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu Ser
                165                 170                 175     
Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln Ala
            180                 185                 190         
Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe
        195                 200                 205             
Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu
    210                 215                 220                 
Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe
225                 230                 235                 240 
Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr
                245                 250                 255     
Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val
            260                 265                 270         
Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp
        275                 280                 285             
Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys
    290                 295                 300                 
Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys
305                 310                 315                 320 
Lys Lys Lys
            


<210> 136
<211> 972
<212> DNA
<213> Homo sapiens

<400> 136
atggtggaag aacccagagc aaagtacctg aactatgagg atgggaaatt ctctaagagc 60
cgcggtgtgg gagtgtttgg ggacatggcc caggacacgg ggatccctgc tgacatctgg 120
cgcttctatc tgctgtacat tcggcctgag ggccaggaca gtgctttctc ctggacggac 180
ctgctgctga agaataattc tgagctgctt aacaacctgg gcaacttcat caacagagct 240
gggatgtttg tgtctaagtt ctttgggggc tatgtgcctg agatggtgct cacccctgat 300
gatcagcgcc tgctggccca tgtcaccctg gagctccagc actatcacca gctacttgag 360
aaggttcgga tccgggatgc cttgcgcagt atcctcacca tatctcgaca tggcaaccaa 420
tatattcagg tgaatgagcc ctggaagcgg attaaaggca gtgaggctga caggcaacgg 480
gcaggaacag tgactggctt ggcagtgaat atagctgcct tgctctctgt catgcttcag 540
ccttacatgc ccacggttag tgccacaatc caggcccagc tgcagctccc acctccagcc 600
tgcagtatcc tgctgacaaa cttcctgtgt accttaccag caggacacca gattggcaca 660
gtcagtccct tgttccaaaa attggaaaat gaccagattg aaagtttaag gcagcgcttt 720
ggagggggcc aggcaaaaac gtccccgaag ccagcagttg tagagactgt tacaacagcc 780
aagccacagc agatacaagc gctgatggat gaagtgacaa aacaaggaaa cattgtccga 840
gaactgaaag cacaaaaggc agacaagaac gaggttgctg cggaggtggc gaaactcttg 900
gatctaaaga aacagttggc tgtagctgag gggaaacccc ctgaagcccc taaaggcaag 960
aagaaaaagt aa                                                     972

<210> 137
<211> 55
<212> PRT
<213> Homo sapiens

<400> 137
Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala
 1               5                  10                  15      
Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu
            20                  25                  30          
Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala
        35                  40                  45              
Pro Lys Gly Lys Lys Lys Lys
    50                  55  


<210> 138
<211> 168
<212> DNA
<213> Homo sapiens

<400> 138
atggatgaag tgacaaaaca aggaaacatt gtccgagaac tgaaagcaca aaaggcagac 60
aagaacgagg ttgctgcgga ggtggcgaaa ctcttggatc taaagaaaca gttggctgta 120
gctgagggga aaccccctga agcccctaaa ggcaagaaga aaaagtaa              168

<210> 139
<211> 773
<212> PRT
<213> Homo sapiens

<400> 139
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr
        35                  40                  45              
Leu Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys
    50                  55                  60                  
Gln Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln
65                  70                  75                  80  
Pro Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu
                85                  90                  95      
Glu Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala
            100                 105                 110         
Trp Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn
        115                 120                 125             
Pro Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala
    130                 135                 140                 
Leu Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys
145                 150                 155                 160 
Val Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp
                165                 170                 175     
Asn Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu
            180                 185                 190         
Thr Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys
        195                 200                 205             
Tyr His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe
    210                 215                 220                 
Asp Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln
225                 230                 235                 240 
Asp Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr
                245                 250                 255     
Val Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg
            260                 265                 270         
Phe Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly
        275                 280                 285             
Asp Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys
    290                 295                 300                 
Lys Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser
305                 310                 315                 320 
Gln His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu
                325                 330                 335     
Trp Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln
            340                 345                 350         
Phe Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile
        355                 360                 365             
Thr Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu
    370                 375                 380                 
Asp Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser
385                 390                 395                 400 
Ile Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro
                405                 410                 415     
Glu Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe
            420                 425                 430         
His Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr
        435                 440                 445             
Thr Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp
    450                 455                 460                 
Gly Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala
465                 470                 475                 480 
Gln Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr
                485                 490                 495     
Ile Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu
            500                 505                 510         
Leu Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn
        515                 520                 525             
Arg Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu
    530                 535                 540                 
Met Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu
545                 550                 555                 560 
Glu Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp
                565                 570                 575     
Ala Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile
            580                 585                 590         
Gln Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg
        595                 600                 605             
Gln Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu
    610                 615                 620                 
Leu Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile
625                 630                 635                 640 
Gln Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr
                645                 650                 655     
Asn Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser
            660                 665                 670         
Pro Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln
        675                 680                 685             
Arg Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val
    690                 695                 700                 
Glu Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp
705                 710                 715                 720 
Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys
                725                 730                 735     
Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu
            740                 745                 750         
Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys
        755                 760                 765             
Gly Lys Lys Lys Lys
    770             


<210> 140
<211> 2322
<212> DNA
<213> Homo sapiens

<400> 140
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ggagctgagt 120
gccctgcaca gctggttcca gacactgagt acccaggaac catgtcagcg agctgcagag 180
actgtactga aacagcaagg tgtcctggct ctccggcctt acctccaaaa gcagccccag 240
cccagccccg ctgagggaag ggctgtcacc aatgagcctg aggaggagga gctggctacc 300
ctatctgagg aggagattgc tatggctgtt actgcttggg agaagggcct agaaagtttg 360
cccccgctgc ggccccagca gaatccagtg ttgcctgtgg ctggagaaag gaatgtgctc 420
atcaccagtg ccctccctta cgtcaacaat gtcccccacc ttgggaacat cattggttgt 480
gtgctcagtg ccgatgtctt tgccaggtac tctcgcctcc gccagtggaa caccctctat 540
ctgtgtggga cagatgagta tggtacagca acagagacca aggctctgga ggagggacta 600
accccccagg agatctgcga caagtaccac atcatccatg ctgacatcta ccgctggttt 660
aacatttcgt ttgatatttt tggtcgcacc accactccac agcagaccaa aatcacccag 720
gacattttcc agcagttgct gaaacgaggt tttgtgctgc aagatactgt ggagcaactg 780
cgatgtgagc actgtgctcg cttcctggct gaccgcttcg tggagggcgt gtgtcccttc 840
tgtggctatg aggaggctcg gggtgaccag tgtgacaagt gtggcaagct catcaatgct 900
gtcgagctta agaagcctca gtgtaaagtc tgccgatcat gccctgtggt gcagtcgagc 960
cagcacctgt ttctggacct gcctaagctg gagaagcgac tggaggagtg gttggggagg 1020
acattgcctg gcagtgactg gacacccaat gcccagttta tcacccgttc ttggcttcgg 1080
gatggcctca agccacgctg cataacccga gacctcaaat ggggaacccc tgtaccctta 1140
gaaggttttg aagacaaggt attctatgtc tggtttgatg ccactattgg ctatctgtcc 1200
atcacagcca actacacaga ccagtgggag agatggtgga agaacccaga gcaagtggac 1260
ctgtatcagt tcatggccaa agacaatgtt cctttccata gcttagtctt tccttgctca 1320
gccctaggag ctgaggataa ctataccttg gtcagccacc tcattgctac agagtacctg 1380
aactatgagg atgggaaatt ctctaagagc cgcggtgtgg gagtgtttgg ggacatggcc 1440
caggacacgg ggatccctgc tgacatctgg cgcttctatc tgctgtacat tcggcctgag 1500
ggccaggaca gtgctttctc ctggacggac ctgctgctga agaataattc tgagctgctt 1560
aacaacctgg gcaacttcat caacagagct gggatgtttg tgtctaagtt ctttgggggc 1620
tatgtgcctg agatggtgct cacccctgat gatcagcgcc tgctggccca tgtcaccctg 1680
gagctccagc actatcacca gctacttgag aaggttcgga tccgggatgc cttgcgcagt 1740
atcctcacca tatctcgaca tggcaaccaa tatattcagg tgaatgagcc ctggaagcgg 1800
attaaaggca gtgaggctga caggcaacgg gcaggaacag tgactggctt ggcagtgaat 1860
atagctgcct tgctctctgt catgcttcag ccttacatgc ccacggttag tgccacaatc 1920
caggcccagc tgcagctccc acctccagcc tgcagtatcc tgctgacaaa cttcctgtgt 1980
accttaccag caggacacca gattggcaca gtcagtccct tgttccaaaa attggaaaat 2040
gaccagattg aaagtttaag gcagcgcttt ggagggggcc aggcaaaaac gtccccgaag 2100
ccagcagttg tagagactgt tacaacagcc aagccacagc agatacaagc gctgatggat 2160
gaagtgacaa aacaaggaaa cattgtccga gaactgaaag cacaaaaggc agacaagaac 2220
gaggttgctg cggaggtggc gaaactcttg gatctaaaga aacagttggc tgtagctgag 2280
gggaaacccc ctgaagcccc taaaggcaag aagaaaaagt aa                    2322

<210> 141
<211> 666
<212> PRT
<213> Homo sapiens

<400> 141
Met Ala Val Thr Ala Trp Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu
 1               5                  10                  15      
Arg Pro Gln Gln Asn Pro Val Leu Pro Val Ala Gly Glu Arg Asn Val
            20                  25                  30          
Leu Ile Thr Ser Ala Leu Pro Tyr Val Asn Asn Val Pro His Leu Gly
        35                  40                  45              
Asn Ile Ile Gly Cys Val Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser
    50                  55                  60                  
Arg Leu Arg Gln Trp Asn Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr
65                  70                  75                  80  
Gly Thr Ala Thr Glu Thr Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln
                85                  90                  95      
Glu Ile Cys Asp Lys Tyr His Ile Ile His Ala Asp Ile Tyr Arg Trp
            100                 105                 110         
Phe Asn Ile Ser Phe Asp Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln
        115                 120                 125             
Thr Lys Ile Thr Gln Asp Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe
    130                 135                 140                 
Val Leu Gln Asp Thr Val Glu Gln Leu Arg Cys Glu His Cys Ala Arg
145                 150                 155                 160 
Phe Leu Ala Asp Arg Phe Val Glu Gly Val Cys Pro Phe Cys Gly Tyr
                165                 170                 175     
Glu Glu Ala Arg Gly Asp Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn
            180                 185                 190         
Ala Val Glu Leu Lys Lys Pro Gln Cys Lys Val Cys Arg Ser Cys Pro
        195                 200                 205             
Val Val Gln Ser Ser Gln His Leu Phe Leu Asp Leu Pro Lys Leu Glu
    210                 215                 220                 
Lys Arg Leu Glu Glu Trp Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp
225                 230                 235                 240 
Thr Pro Asn Ala Gln Phe Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu
                245                 250                 255     
Lys Pro Arg Cys Ile Thr Arg Asp Leu Lys Trp Gly Thr Pro Val Pro
            260                 265                 270         
Leu Glu Gly Phe Glu Asp Lys Val Phe Tyr Val Trp Phe Asp Ala Thr
        275                 280                 285             
Ile Gly Tyr Leu Ser Ile Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg
    290                 295                 300                 
Trp Trp Lys Asn Pro Glu Gln Val Asp Leu Tyr Gln Phe Met Ala Lys
305                 310                 315                 320 
Asp Asn Val Pro Phe His Ser Leu Val Phe Pro Cys Ser Ala Leu Gly
                325                 330                 335     
Ala Glu Asp Asn Tyr Thr Leu Val Ser His Leu Ile Ala Thr Glu Tyr
            340                 345                 350         
Leu Asn Tyr Glu Asp Gly Lys Phe Ser Lys Ser Arg Gly Val Gly Val
        355                 360                 365             
Phe Gly Asp Met Ala Gln Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg
    370                 375                 380                 
Phe Tyr Leu Leu Tyr Ile Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser
385                 390                 395                 400 
Trp Thr Asp Leu Leu Leu Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu
                405                 410                 415     
Gly Asn Phe Ile Asn Arg Ala Gly Met Phe Val Ser Lys Phe Phe Gly
            420                 425                 430         
Gly Tyr Val Pro Glu Met Val Leu Thr Pro Asp Asp Gln Arg Leu Leu
        435                 440                 445             
Ala His Val Thr Leu Glu Leu Gln His Tyr His Gln Leu Leu Glu Lys
    450                 455                 460                 
Val Arg Ile Arg Asp Ala Leu Arg Ser Ile Leu Thr Ile Ser Arg His
465                 470                 475                 480 
Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg Ile Lys Gly
                485                 490                 495     
Ser Glu Ala Asp Arg Gln Arg Ala Gly Thr Val Thr Gly Leu Ala Val
            500                 505                 510         
Asn Ile Ala Ala Leu Leu Ser Val Met Leu Gln Pro Tyr Met Pro Thr
        515                 520                 525             
Val Ser Ala Thr Ile Gln Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys
    530                 535                 540                 
Ser Ile Leu Leu Thr Asn Phe Leu Cys Thr Leu Pro Ala Gly His Gln
545                 550                 555                 560 
Ile Gly Thr Val Ser Pro Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile
                565                 570                 575     
Glu Ser Leu Arg Gln Arg Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro
            580                 585                 590         
Lys Pro Ala Val Val Glu Thr Val Thr Thr Ala Lys Pro Gln Gln Ile
        595                 600                 605             
Gln Ala Leu Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu
    610                 615                 620                 
Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala
625                 630                 635                 640 
Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro
                645                 650                 655     
Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
            660                 665     


<210> 142
<211> 2001
<212> DNA
<213> Homo sapiens

<400> 142
atggctgtta ctgcttggga gaagggccta gaaagtttgc ccccgctgcg gccccagcag 60
aatccagtgt tgcctgtggc tggagaaagg aatgtgctca tcaccagtgc cctcccttac 120
gtcaacaatg tcccccacct tgggaacatc attggttgtg tgctcagtgc cgatgtcttt 180
gccaggtact ctcgcctccg ccagtggaac accctctatc tgtgtgggac agatgagtat 240
ggtacagcaa cagagaccaa ggctctggag gagggactaa ccccccagga gatctgcgac 300
aagtaccaca tcatccatgc tgacatctac cgctggttta acatttcgtt tgatattttt 360
ggtcgcacca ccactccaca gcagaccaaa atcacccagg acattttcca gcagttgctg 420
aaacgaggtt ttgtgctgca agatactgtg gagcaactgc gatgtgagca ctgtgctcgc 480
ttcctggctg accgcttcgt ggagggcgtg tgtcccttct gtggctatga ggaggctcgg 540
ggtgaccagt gtgacaagtg tggcaagctc atcaatgctg tcgagcttaa gaagcctcag 600
tgtaaagtct gccgatcatg ccctgtggtg cagtcgagcc agcacctgtt tctggacctg 660
cctaagctgg agaagcgact ggaggagtgg ttggggagga cattgcctgg cagtgactgg 720
acacccaatg cccagtttat cacccgttct tggcttcggg atggcctcaa gccacgctgc 780
ataacccgag acctcaaatg gggaacccct gtacccttag aaggttttga agacaaggta 840
ttctatgtct ggtttgatgc cactattggc tatctgtcca tcacagccaa ctacacagac 900
cagtgggaga gatggtggaa gaacccagag caagtggacc tgtatcagtt catggccaaa 960
gacaatgttc ctttccatag cttagtcttt ccttgctcag ccctaggagc tgaggataac 1020
tataccttgg tcagccacct cattgctaca gagtacctga actatgagga tgggaaattc 1080
tctaagagcc gcggtgtggg agtgtttggg gacatggccc aggacacggg gatccctgct 1140
gacatctggc gcttctatct gctgtacatt cggcctgagg gccaggacag tgctttctcc 1200
tggacggacc tgctgctgaa gaataattct gagctgctta acaacctggg caacttcatc 1260
aacagagctg ggatgtttgt gtctaagttc tttgggggct atgtgcctga gatggtgctc 1320
acccctgatg atcagcgcct gctggcccat gtcaccctgg agctccagca ctatcaccag 1380
ctacttgaga aggttcggat ccgggatgcc ttgcgcagta tcctcaccat atctcgacat 1440
ggcaaccaat atattcaggt gaatgagccc tggaagcgga ttaaaggcag tgaggctgac 1500
aggcaacggg caggaacagt gactggcttg gcagtgaata tagctgcctt gctctctgtc 1560
atgcttcagc cttacatgcc cacggttagt gccacaatcc aggcccagct gcagctccca 1620
cctccagcct gcagtatcct gctgacaaac ttcctgtgta ccttaccagc aggacaccag 1680
attggcacag tcagtccctt gttccaaaaa ttggaaaatg accagattga aagtttaagg 1740
cagcgctttg gagggggcca ggcaaaaacg tccccgaagc cagcagttgt agagactgtt 1800
acaacagcca agccacagca gatacaagcg ctgatggatg aagtgacaaa acaaggaaac 1860
attgtccgag aactgaaagc acaaaaggca gacaagaacg aggttgctgc ggaggtggcg 1920
aaactcttgg atctaaagaa acagttggct gtagctgagg ggaaaccccc tgaagcccct 1980
aaaggcaaga agaaaaagta a                                           2001

<210> 143
<211> 647
<212> PRT
<213> Homo sapiens

<400> 143
Met Ser Leu Arg Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr
 1               5                  10                  15      
Ser Ala Leu Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile
            20                  25                  30          
Gly Cys Val Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg
        35                  40                  45              
Gln Trp Asn Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala
    50                  55                  60                  
Thr Glu Thr Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys
65                  70                  75                  80  
Asp Lys Tyr His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile
                85                  90                  95      
Ser Phe Asp Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile
            100                 105                 110         
Thr Gln Asp Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln
        115                 120                 125             
Asp Thr Val Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala
    130                 135                 140                 
Asp Arg Phe Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala
145                 150                 155                 160 
Arg Gly Asp Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu
                165                 170                 175     
Leu Lys Lys Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln
            180                 185                 190         
Ser Ser Gln His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu
        195                 200                 205             
Glu Glu Trp Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn
    210                 215                 220                 
Ala Gln Phe Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg
225                 230                 235                 240 
Cys Ile Thr Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly
                245                 250                 255     
Phe Glu Asp Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr
            260                 265                 270         
Leu Ser Ile Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys
        275                 280                 285             
Asn Pro Glu Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val
    290                 295                 300                 
Pro Phe His Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp
305                 310                 315                 320 
Asn Tyr Thr Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr
                325                 330                 335     
Glu Asp Gly Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp
            340                 345                 350         
Met Ala Gln Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu
        355                 360                 365             
Leu Tyr Ile Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp
    370                 375                 380                 
Leu Leu Leu Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe
385                 390                 395                 400 
Ile Asn Arg Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val
                405                 410                 415     
Pro Glu Met Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val
            420                 425                 430         
Thr Leu Glu Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile
        435                 440                 445             
Arg Asp Ala Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln
    450                 455                 460                 
Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala
465                 470                 475                 480 
Asp Arg Gln Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala
                485                 490                 495     
Ala Leu Leu Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala
            500                 505                 510         
Thr Ile Gln Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu
        515                 520                 525             
Leu Thr Asn Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr
    530                 535                 540                 
Val Ser Pro Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu
545                 550                 555                 560 
Arg Gln Arg Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala
                565                 570                 575     
Val Val Glu Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu
            580                 585                 590         
Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala
        595                 600                 605             
Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu
    610                 615                 620                 
Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala
625                 630                 635                 640 
Pro Lys Gly Lys Lys Lys Lys
                645         


<210> 144
<211> 1944
<212> DNA
<213> Homo sapiens

<400> 144
atgagcctga ggttgcctgt ggctggagaa aggaatgtgc tcatcaccag tgccctccct 60
tacgtcaaca atgtccccca ccttgggaac atcattggtt gtgtgctcag tgccgatgtc 120
tttgccaggt actctcgcct ccgccagtgg aacaccctct atctgtgtgg gacagatgag 180
tatggtacag caacagagac caaggctctg gaggagggac taacccccca ggagatctgc 240
gacaagtacc acatcatcca tgctgacatc taccgctggt ttaacatttc gtttgatatt 300
tttggtcgca ccaccactcc acagcagacc aaaatcaccc aggacatttt ccagcagttg 360
ctgaaacgag gttttgtgct gcaagatact gtggagcaac tgcgatgtga gcactgtgct 420
cgcttcctgg ctgaccgctt cgtggagggc gtgtgtccct tctgtggcta tgaggaggct 480
cggggtgacc agtgtgacaa gtgtggcaag ctcatcaatg ctgtcgagct taagaagcct 540
cagtgtaaag tctgccgatc atgccctgtg gtgcagtcga gccagcacct gtttctggac 600
ctgcctaagc tggagaagcg actggaggag tggttgggga ggacattgcc tggcagtgac 660
tggacaccca atgcccagtt tatcacccgt tcttggcttc gggatggcct caagccacgc 720
tgcataaccc gagacctcaa atggggaacc cctgtaccct tagaaggttt tgaagacaag 780
gtattctatg tctggtttga tgccactatt ggctatctgt ccatcacagc caactacaca 840
gaccagtggg agagatggtg gaagaaccca gagcaagtgg acctgtatca gttcatggcc 900
aaagacaatg ttcctttcca tagcttagtc tttccttgct cagccctagg agctgaggat 960
aactatacct tggtcagcca cctcattgct acagagtacc tgaactatga ggatgggaaa 1020
ttctctaaga gccgcggtgt gggagtgttt ggggacatgg cccaggacac ggggatccct 1080
gctgacatct ggcgcttcta tctgctgtac attcggcctg agggccagga cagtgctttc 1140
tcctggacgg acctgctgct gaagaataat tctgagctgc ttaacaacct gggcaacttc 1200
atcaacagag ctgggatgtt tgtgtctaag ttctttgggg gctatgtgcc tgagatggtg 1260
ctcacccctg atgatcagcg cctgctggcc catgtcaccc tggagctcca gcactatcac 1320
cagctacttg agaaggttcg gatccgggat gccttgcgca gtatcctcac catatctcga 1380
catggcaacc aatatattca ggtgaatgag ccctggaagc ggattaaagg cagtgaggct 1440
gacaggcaac gggcaggaac agtgactggc ttggcagtga atatagctgc cttgctctct 1500
gtcatgcttc agccttacat gcccacggtt agtgccacaa tccaggccca gctgcagctc 1560
ccacctccag cctgcagtat cctgctgaca aacttcctgt gtaccttacc agcaggacac 1620
cagattggca cagtcagtcc cttgttccaa aaattggaaa atgaccagat tgaaagttta 1680
aggcagcgct ttggaggggg ccaggcaaaa acgtccccga agccagcagt tgtagagact 1740
gttacaacag ccaagccaca gcagatacaa gcgctgatgg atgaagtgac aaaacaagga 1800
aacattgtcc gagaactgaa agcacaaaag gcagacaaga acgaggttgc tgcggaggtg 1860
gcgaaactct tggatctaaa gaaacagttg gctgtagctg aggggaaacc ccctgaagcc 1920
cctaaaggca agaagaaaaa gtaa                                        1944

<210> 145
<211> 832
<212> PRT
<213> Homo sapiens

<400> 145
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Ile Thr Gln Asp Ile Phe Gln Gln
    290                 295                 300                 
Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val Glu Gln Leu Arg
305                 310                 315                 320 
Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe Val Glu Gly Val
                325                 330                 335     
Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp Gln Cys Asp Lys
            340                 345                 350         
Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys Pro Gln Cys Lys
        355                 360                 365             
Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln His Leu Phe Leu
    370                 375                 380                 
Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp Leu Gly Arg Thr
385                 390                 395                 400 
Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe Ile Thr Arg Ser
                405                 410                 415     
Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr Arg Asp Leu Lys
            420                 425                 430         
Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp Lys Val Phe Tyr
        435                 440                 445             
Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile Thr Ala Asn Tyr
    450                 455                 460                 
Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu Gln Val Asp Leu
465                 470                 475                 480 
Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His Ser Leu Val Phe
                485                 490                 495     
Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr Leu Val Ser His
            500                 505                 510         
Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys Phe Ser Lys
        515                 520                 525             
Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln Asp Thr Gly Ile
    530                 535                 540                 
Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg Pro Glu Gly
545                 550                 555                 560 
Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys Asn Asn Ser
                565                 570                 575     
Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala Gly Met Phe
            580                 585                 590         
Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met Val Leu Thr Pro
        595                 600                 605             
Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu Leu Gln His Tyr
    610                 615                 620                 
His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala Leu Arg Ser Ile
625                 630                 635                 640 
Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro
                645                 650                 655     
Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg Ala Gly Thr
            660                 665                 670         
Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu Ser Val Met Leu
        675                 680                 685             
Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln Ala Gln Leu Gln
    690                 695                 700                 
Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys Thr
705                 710                 715                 720 
Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu Phe Gln Lys
                725                 730                 735     
Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly Gly
            740                 745                 750         
Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr Thr
        755                 760                 765             
Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys Gln
    770                 775                 780                 
Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu
785                 790                 795                 800 
Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala
                805                 810                 815     
Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
            820                 825                 830         


<210> 146
<211> 2499
<212> DNA
<213> Homo sapiens

<400> 146
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccagaat cacccaggac 900
attttccagc agttgctgaa acgaggtttt gtgctgcaag atactgtgga gcaactgcga 960
tgtgagcact gtgctcgctt cctggctgac cgcttcgtgg agggcgtgtg tcccttctgt 1020
ggctatgagg aggctcgggg tgaccagtgt gacaagtgtg gcaagctcat caatgctgtc 1080
gagcttaaga agcctcagtg taaagtctgc cgatcatgcc ctgtggtgca gtcgagccag 1140
cacctgtttc tggacctgcc taagctggag aagcgactgg aggagtggtt ggggaggaca 1200
ttgcctggca gtgactggac acccaatgcc cagtttatca cccgttcttg gcttcgggat 1260
ggcctcaagc cacgctgcat aacccgagac ctcaaatggg gaacccctgt acccttagaa 1320
ggttttgaag acaaggtatt ctatgtctgg tttgatgcca ctattggcta tctgtccatc 1380
acagccaact acacagacca gtgggagaga tggtggaaga acccagagca agtggacctg 1440
tatcagttca tggccaaaga caatgttcct ttccatagct tagtctttcc ttgctcagcc 1500
ctaggagctg aggataacta taccttggtc agccacctca ttgctacaga gtacctgaac 1560
tatgaggatg ggaaattctc taagagccgc ggtgtgggag tgtttgggga catggcccag 1620
gacacgggga tccctgctga catctggcgc ttctatctgc tgtacattcg gcctgagggc 1680
caggacagtg ctttctcctg gacggacctg ctgctgaaga ataattctga gctgcttaac 1740
aacctgggca acttcatcaa cagagctggg atgtttgtgt ctaagttctt tgggggctat 1800
gtgcctgaga tggtgctcac ccctgatgat cagcgcctgc tggcccatgt caccctggag 1860
ctccagcact atcaccagct acttgagaag gttcggatcc gggatgcctt gcgcagtatc 1920
ctcaccatat ctcgacatgg caaccaatat attcaggtga atgagccctg gaagcggatt 1980
aaaggcagtg aggctgacag gcaacgggca ggaacagtga ctggcttggc agtgaatata 2040
gctgccttgc tctctgtcat gcttcagcct tacatgccca cggttagtgc cacaatccag 2100
gcccagctgc agctcccacc tccagcctgc agtatcctgc tgacaaactt cctgtgtacc 2160
ttaccagcag gacaccagat tggcacagtc agtcccttgt tccaaaaatt ggaaaatgac 2220
cagattgaaa gtttaaggca gcgctttgga gggggccagg caaaaacgtc cccgaagcca 2280
gcagttgtag agactgttac aacagccaag ccacagcaga tacaagcgct gatggatgaa 2340
gtgacaaaac aaggaaacat tgtccgagaa ctgaaagcac aaaaggcaga caagaacgag 2400
gttgctgcgg aggtggcgaa actcttggat ctaaagaaac agttggctgt agctgagggg 2460
aaaccccctg aagcccctaa aggcaagaag aaaaagtaa                        2499

<210> 147
<211> 875
<212> PRT
<213> Homo sapiens

<400> 147
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
 1               5                  10                  15      
Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
            20                  25                  30          
Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
        35                  40                  45              
Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
    50                  55                  60                  
Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
65                  70                  75                  80  
Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                85                  90                  95      
Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110         
Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125             
Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140                 
Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 
Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175     
Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190         
Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205             
Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220                 
Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 
Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255     
Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270         
Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285             
Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300                 
Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 
Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335     
His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350         
Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365             
Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380                 
Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 
Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415     
Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Leu
            420                 425                 430         
Glu Lys Arg Leu Glu Glu Trp Leu Gly Arg Thr Leu Pro Gly Ser Asp
        435                 440                 445             
Trp Thr Pro Asn Ala Gln Phe Ile Thr Arg Ser Trp Leu Arg Asp Gly
    450                 455                 460                 
Leu Lys Pro Arg Cys Ile Thr Arg Asp Leu Lys Trp Gly Thr Pro Val
465                 470                 475                 480 
Pro Leu Glu Gly Phe Glu Asp Lys Val Phe Tyr Val Trp Phe Asp Ala
                485                 490                 495     
Thr Ile Gly Tyr Leu Ser Ile Thr Ala Asn Tyr Thr Asp Gln Trp Glu
            500                 505                 510         
Arg Trp Trp Lys Asn Pro Glu Gln Val Asp Leu Tyr Gln Phe Met Ala
        515                 520                 525             
Lys Asp Asn Val Pro Phe His Ser Leu Val Phe Pro Cys Ser Ala Leu
    530                 535                 540                 
Gly Ala Glu Asp Asn Tyr Thr Leu Val Ser His Leu Ile Ala Thr Glu
545                 550                 555                 560 
Tyr Leu Asn Tyr Glu Asp Gly Lys Phe Ser Lys Ser Arg Gly Val Gly
                565                 570                 575     
Val Phe Gly Asp Met Ala Gln Asp Thr Gly Ile Pro Ala Asp Ile Trp
            580                 585                 590         
Arg Phe Tyr Leu Leu Tyr Ile Arg Pro Glu Gly Gln Asp Ser Ala Phe
        595                 600                 605             
Ser Trp Thr Asp Leu Leu Leu Lys Asn Asn Ser Glu Leu Leu Asn Asn
    610                 615                 620                 
Leu Gly Asn Phe Ile Asn Arg Ala Gly Met Phe Val Ser Lys Phe Phe
625                 630                 635                 640 
Gly Gly Tyr Val Pro Glu Met Val Leu Thr Pro Asp Asp Gln Arg Leu
                645                 650                 655     
Leu Ala His Val Thr Leu Glu Leu Gln His Tyr His Gln Leu Leu Glu
            660                 665                 670         
Lys Val Arg Ile Arg Asp Ala Leu Arg Ser Ile Leu Thr Ile Ser Arg
        675                 680                 685             
His Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg Ile Lys
    690                 695                 700                 
Gly Ser Glu Ala Asp Arg Gln Arg Ala Gly Thr Val Thr Gly Leu Ala
705                 710                 715                 720 
Val Asn Ile Ala Ala Leu Leu Ser Val Met Leu Gln Pro Tyr Met Pro
                725                 730                 735     
Thr Val Ser Ala Thr Ile Gln Ala Gln Leu Gln Leu Pro Pro Pro Ala
            740                 745                 750         
Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys Thr Leu Pro Ala Gly His
        755                 760                 765             
Gln Ile Gly Thr Val Ser Pro Leu Phe Gln Lys Leu Glu Asn Asp Gln
    770                 775                 780                 
Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly Gly Gln Ala Lys Thr Ser
785                 790                 795                 800 
Pro Lys Pro Ala Val Val Glu Thr Val Thr Thr Ala Lys Pro Gln Gln
                805                 810                 815     
Ile Gln Ala Leu Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg
            820                 825                 830         
Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val
        835                 840                 845             
Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys
    850                 855                 860                 
Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
865                 870                 875 


<210> 148
<211> 2628
<212> DNA
<213> Homo sapiens

<400> 148
atgagactgt tcgtgagtga tggcgtcccg ggttgcttgc cggtgctggc cgccgccggg 60
agagcccggg gcagagcaga ggtgctcatc agcactgtag gcccggaaga ttgtgtggtc 120
ccgttcctga cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa ctacctcttc 180
tccactagtg caatctgccg atattttttt ttgttatctg gctgggagca agatgacctc 240
actaaccagt ggctggaatg ggaagcgaca gagctgcagc cagctttgtc tgctgccctg 300
tactatttag tggtccaagg caagaagggg gaagatgttc ttggttcagt gcggagagcc 360
ctgactcaca ttgaccacag cttgagtcgt cagaactgtc ctttcctggc tggggagaca 420
gaatctctag ccgacattgt tttgtgggga gccctatacc cattactgca agatcccgcc 480
tacctccctg aggagctgag tgccctgcac agctggttcc agacactgag tacccaggaa 540
ccatgtcagc gagctgcaga gactgtactg aaacagcaag gtgtcctggc tctccggcct 600
tacctccaaa agcagcccca gcccagcccc gctgagggaa gggctgtcac caatgagcct 660
gaggaggagg agctggctac cctatctgag gaggagattg ctatggctgt tactgcttgg 720
gagaagggcc tagaaagttt gcccccgctg cggccccagc agaatccagt gttgcctgtg 780
gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 840
cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 900
cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 960
aaggctctgg aggagggact aaccccccag gagatctgcg acaagtacca catcatccat 1020
gctgacatct accgctggtt taacatttcg tttgatattt ttggtcgcac caccactcca 1080
cagcagacca aaatcaccca ggacattttc cagcagttgc tgaaacgagg ttttgtgctg 1140
caagatactg tggagcaact gcgatgtgag cactgtgctc gcttcctggc tgaccgcttc 1200
gtggagggcg tgtgtccctt ctgtggctat gaggaggctc ggggtgacca gtgtgacaag 1260
tgtggcaagc tcatcaatgc tgtcgagctt aagctggaga agcgactgga ggagtggttg 1320
gggaggacat tgcctggcag tgactggaca cccaatgccc agtttatcac ccgttcttgg 1380
cttcgggatg gcctcaagcc acgctgcata acccgagacc tcaaatgggg aacccctgta 1440
cccttagaag gttttgaaga caaggtattc tatgtctggt ttgatgccac tattggctat 1500
ctgtccatca cagccaacta cacagaccag tgggagagat ggtggaagaa cccagagcaa 1560
gtggacctgt atcagttcat ggccaaagac aatgttcctt tccatagctt agtctttcct 1620
tgctcagccc taggagctga ggataactat accttggtca gccacctcat tgctacagag 1680
tacctgaact atgaggatgg gaaattctct aagagccgcg gtgtgggagt gtttggggac 1740
atggcccagg acacggggat ccctgctgac atctggcgct tctatctgct gtacattcgg 1800
cctgagggcc aggacagtgc tttctcctgg acggacctgc tgctgaagaa taattctgag 1860
ctgcttaaca acctgggcaa cttcatcaac agagctggga tgtttgtgtc taagttcttt 1920
gggggctatg tgcctgagat ggtgctcacc cctgatgatc agcgcctgct ggcccatgtc 1980
accctggagc tccagcacta tcaccagcta cttgagaagg ttcggatccg ggatgccttg 2040
cgcagtatcc tcaccatatc tcgacatggc aaccaatata ttcaggtgaa tgagccctgg 2100
aagcggatta aaggcagtga ggctgacagg caacgggcag gaacagtgac tggcttggca 2160
gtgaatatag ctgccttgct ctctgtcatg cttcagcctt acatgcccac ggttagtgcc 2220
acaatccagg cccagctgca gctcccacct ccagcctgca gtatcctgct gacaaacttc 2280
ctgtgtacct taccagcagg acaccagatt ggcacagtca gtcccttgtt ccaaaaattg 2340
gaaaatgacc agattgaaag tttaaggcag cgctttggag ggggccaggc aaaaacgtcc 2400
ccgaagccag cagttgtaga gactgttaca acagccaagc cacagcagat acaagcgctg 2460
atggatgaag tgacaaaaca aggaaacatt gtccgagaac tgaaagcaca aaaggcagac 2520
aagaacgagg ttgctgcgga ggtggcgaaa ctcttggatc taaagaaaca gttggctgta 2580
gctgagggga aaccccctga agcccctaaa ggcaagaaga aaaagtaa              2628

<210> 149
<211> 50
<212> DNA
<213> Homo sapiens

<400> 149
tcttctccac tagtgcaatc tgccggtatt ctatgtctgg tttgatgcca            50

<210> 150
<211> 50
<212> DNA
<213> Homo sapiens

<400> 150
gcaccaccac tccacagcag accaaaagcc tcagtgtaaa gtctgccgat            50

<210> 151
<211> 50
<212> DNA
<213> Homo sapiens

<400> 151
gagatggtgg aagaacccag agcaaagtac ctgaactatg aggatgggaa            50

<210> 152
<211> 15
<212> PRT
<213> Homo sapiens

<400> 152
Met Val Glu Glu Pro Arg Ala Lys Tyr Leu Asn Tyr Glu Asp Gly
 1               5                  10                  15  


<210> 153
<211> 50
<212> DNA
<213> Homo sapiens

<400> 153
ggattaaagg cagtgaggct gacaggtcag tcccttgttc caaaaattgg            50

<210> 154
<211> 50
<212> DNA
<213> Homo sapiens

<400> 154
ctcatcagca ctgtaggccc ggaagaggag ctgagtgccc tgcacagctg            50

<210> 155
<211> 16
<212> PRT
<213> Homo sapiens

<400> 155
Leu Ile Ser Thr Val Gly Pro Glu Glu Glu Leu Ser Ala Leu His Ser
 1               5                  10                  15      


<210> 156
<211> 50
<212> DNA
<213> Homo sapiens

<400> 156
tcttctccac tagtgcaatc tgccgaggag ctgagtgccc tgcacagctg            50

<210> 157
<211> 50
<212> DNA
<213> Homo sapiens

<400> 157
aagggctgtc accaatgagc ctgaggttgc ctgtggctgg agaaaggaat            50

<210> 158
<211> 16
<212> PRT
<213> Homo sapiens

<400> 158
Gly Leu Ser Pro Met Ser Leu Arg Leu Pro Val Ala Gly Glu Arg Asn
 1               5                  10                  15      


<210> 159
<211> 50
<212> DNA
<213> Homo sapiens

<400> 159
tgctcagtgc cgatgtcttt gccagaatca cccaggacat tttccagcag            50

<210> 160
<211> 16
<212> PRT
<213> Homo sapiens

<400> 160
Leu Ser Ala Asp Val Phe Ala Arg Ile Thr Gln Asp Ile Phe Gln Gln
 1               5                  10                  15      


<210> 161
<211> 50
<212> DNA
<213> Homo sapiens

<400> 161
gctcatcaat gctgtcgagc ttaagctgga gaagcgactg gaggagtggt            50

<210> 162
<211> 16
<212> PRT
<213> Homo sapiens

<400> 162
Leu Ile Asn Ala Val Glu Leu Lys Leu Glu Lys Arg Leu Glu Glu Trp
 1               5                  10                  15      


<210> 163
<211> 128
<212> PRT
<213> Homo sapiens

<400> 163
Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys Thr
 1               5                  10                  15      
Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu Phe Gln Lys
            20                  25                  30          
Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly Gly
        35                  40                  45              
Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr Thr
    50                  55                  60                  
Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys Gln
65                  70                  75                  80  
Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu
                85                  90                  95      
Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala
            100                 105                 110         
Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
        115                 120                 125             


<210> 164
<211> 387
<212> DNA
<213> Homo sapiens

<400> 164
ctcccacctc cagcctgcag tatcctgctg acaaacttcc tgtgtacctt accagcagga 60
caccagattg gcacagtcag tcccttgttc caaaaattgg aaaatgacca gattgaaagt 120
ttaaggcagc gctttggagg gggccaggca aaaacgtccc cgaagccagc agttgtagag 180
actgttacaa cagccaagcc acagcagata caagcgctga tggatgaagt gacaaaacaa 240
ggaaacattg tccgagaact gaaagcacaa aaggcagaca agaacgaggt tgctgcggag 300
gtggcgaaac tcttggatct aaagaaacag ttggctgtag ctgaggggaa accccctgaa 360
gcccctaaag gcaagaagaa aaagtaa                                     387

<210> 165
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 165
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr
            20                  25                  30          
Asn Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser
        35                  40                  45              
Pro Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln
    50                  55                  60                  
Arg Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val
65                  70                  75                  80  
Glu Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp
                85                  90                  95      
Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys
            100                 105                 110         
Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu
        115                 120                 125             
Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys
    130                 135                 140                 
Gly Lys Lys Lys Lys
145                 


<210> 166
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 166
Met Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys
 1               5                  10                  15      
Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu Phe Gln
            20                  25                  30          
Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly
        35                  40                  45              
Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr
    50                  55                  60                  
Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys
65                  70                  75                  80  
Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn
                85                  90                  95      
Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu
            100                 105                 110         
Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys
        115                 120                 125             
Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
    130                 135                 140                 
His His His His His
145                 


<210> 167
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 167
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Lys Asp Asn Val Pro Phe His Ser Leu Val
            20                  25                  30          
Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr Leu Val Ser
        35                  40                  45              
His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys Phe Ser
    50                  55                  60                  
Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln Asp Thr Gly
65                  70                  75                  80  
Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg Pro Glu
                85                  90                  95      
Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys Asn Asn
            100                 105                 110         
Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala Gly Met
        115                 120                 125             
Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met Val Leu Thr
    130                 135                 140                 
Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu Leu Gln His
145                 150                 155                 160 
Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala Leu Arg Ser
                165                 170                 175     
Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln Val Asn Glu
            180                 185                 190         
Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg Ala Gly
        195                 200                 205             
Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu Ser Val Met
    210                 215                 220                 
Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln Ala Gln Leu
225                 230                 235                 240 
Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys
                245                 250                 255     
Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu Phe Gln
            260                 265                 270         
Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly
        275                 280                 285             
Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr
    290                 295                 300                 
Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys
305                 310                 315                 320 
Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn
                325                 330                 335     
Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu
            340                 345                 350         
Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys
        355                 360                 365             
Lys
    


<210> 168
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 168
Met Ala Lys Asp Asn Val Pro Phe His Ser Leu Val Phe Pro Cys Ser
 1               5                  10                  15      
Ala Leu Gly Ala Glu Asp Asn Tyr Thr Leu Val Ser His Leu Ile Ala
            20                  25                  30          
Thr Glu Tyr Leu Asn Tyr Glu Asp Gly Lys Phe Ser Lys Ser Arg Gly
        35                  40                  45              
Val Gly Val Phe Gly Asp Met Ala Gln Asp Thr Gly Ile Pro Ala Asp
    50                  55                  60                  
Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg Pro Glu Gly Gln Asp Ser
65                  70                  75                  80  
Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys Asn Asn Ser Glu Leu Leu
                85                  90                  95      
Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala Gly Met Phe Val Ser Lys
            100                 105                 110         
Phe Phe Gly Gly Tyr Val Pro Glu Met Val Leu Thr Pro Asp Asp Gln
        115                 120                 125             
Arg Leu Leu Ala His Val Thr Leu Glu Leu Gln His Tyr His Gln Leu
    130                 135                 140                 
Leu Glu Lys Val Arg Ile Arg Asp Ala Leu Arg Ser Ile Leu Thr Ile
145                 150                 155                 160 
Ser Arg His Gly Asn Gln Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg
                165                 170                 175     
Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg Ala Gly Thr Val Thr Gly
            180                 185                 190         
Leu Ala Val Asn Ile Ala Ala Leu Leu Ser Val Met Leu Gln Pro Tyr
        195                 200                 205             
Met Pro Thr Val Ser Ala Thr Ile Gln Ala Gln Leu Gln Leu Pro Pro
    210                 215                 220                 
Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe Leu Cys Thr Leu Pro Ala
225                 230                 235                 240 
Gly His Gln Ile Gly Thr Val Ser Pro Leu Phe Gln Lys Leu Glu Asn
                245                 250                 255     
Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe Gly Gly Gly Gln Ala Lys
            260                 265                 270         
Thr Ser Pro Lys Pro Ala Val Val Glu Thr Val Thr Thr Ala Lys Pro
        275                 280                 285             
Gln Gln Ile Gln Ala Leu Met Asp Glu Val Thr Lys Gln Gly Asn Ile
    290                 295                 300                 
Val Arg Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu Val Ala Ala
305                 310                 315                 320 
Glu Val Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Val Ala Glu
                325                 330                 335     
Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys Gly Lys Pro
            340                 345                 350         
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
        355                 360                 365             
His
    


<210> 169
<211> 343
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 169
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Val Glu Glu Pro Arg Ala Lys Tyr Leu Asn Tyr
            20                  25                  30          
Glu Asp Gly Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp
        35                  40                  45              
Met Ala Gln Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu
    50                  55                  60                  
Leu Tyr Ile Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp
65                  70                  75                  80  
Leu Leu Leu Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe
                85                  90                  95      
Ile Asn Arg Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val
            100                 105                 110         
Pro Glu Met Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val
        115                 120                 125             
Thr Leu Glu Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile
    130                 135                 140                 
Arg Asp Ala Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln
145                 150                 155                 160 
Tyr Ile Gln Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala
                165                 170                 175     
Asp Arg Gln Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala
            180                 185                 190         
Ala Leu Leu Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala
        195                 200                 205             
Thr Ile Gln Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu
    210                 215                 220                 
Leu Thr Asn Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr
225                 230                 235                 240 
Val Ser Pro Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu
                245                 250                 255     
Arg Gln Arg Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala
            260                 265                 270         
Val Val Glu Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu
        275                 280                 285             
Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala
    290                 295                 300                 
Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu
305                 310                 315                 320 
Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala
                325                 330                 335     
Pro Lys Gly Lys Lys Lys Lys
            340             


<210> 170
<211> 343
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 170
Met Val Glu Glu Pro Arg Ala Lys Tyr Leu Asn Tyr Glu Asp Gly Lys
 1               5                  10                  15      
Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln Asp
            20                  25                  30          
Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile Arg
        35                  40                  45              
Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu Lys
    50                  55                  60                  
Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg Ala
65                  70                  75                  80  
Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met Val
                85                  90                  95      
Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu Leu
            100                 105                 110         
Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala Leu
        115                 120                 125             
Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln Val
    130                 135                 140                 
Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln Arg
145                 150                 155                 160 
Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu Ser
                165                 170                 175     
Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln Ala
            180                 185                 190         
Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn Phe
        195                 200                 205             
Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro Leu
    210                 215                 220                 
Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg Phe
225                 230                 235                 240 
Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu Thr
                245                 250                 255     
Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu Val
            260                 265                 270         
Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala Asp
        275                 280                 285             
Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys Lys
    290                 295                 300                 
Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly Lys
305                 310                 315                 320 
Lys Lys Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
                325                 330                 335     
Thr His His His His His His
            340             


<210> 171
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 171
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg
            20                  25                  30          
Glu Leu Lys Ala Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val
        35                  40                  45              
Ala Lys Leu Leu Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys
    50                  55                  60                  
Pro Pro Glu Ala Pro Lys Gly Lys Lys Lys Lys
65                  70                  75  


<210> 172
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> Methionyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 172
Met Asp Glu Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala
 1               5                  10                  15      
Gln Lys Ala Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu
            20                  25                  30          
Asp Leu Lys Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala
        35                  40                  45              
Pro Lys Gly Lys Lys Lys Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu
    50                  55                  60                  
Gly Leu Asp Ser Thr His His His His His His
65                  70                  75  


<210> 173
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 173
ttgcctccac cggcgtgcag catcttgctg accaacttcc tgtgcaccct gccggccggt 60
caccaaatcg gtaccgtgag cccgctgttc caaaagctgg agaatgacca aattgagagc 120
ctgcgtcaac gttttggtgg tggccaggcc aaaacgtccc cgaaaccggc agttgtcgaa 180
accgttacca cggcaaaacc gcaacagatt caggcactga tggacgaggt cacgaaacag 240
ggcaacatcg tgcgcgaatt gaaagcgcag aaagcggata agaacgaggt ggctgctgag 300
gtcgcgaagc tgctggattt gaagaaacag ctggcggttg cggaaggcaa accaccggaa 360
gcgcctaaag gtaagaagaa gaagtaatga ctcgag                           396

<210> 174
<211> 1056
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 174
gcgaaagaca acgttccatt tcacagcctg gttttcccgt gtagcgcgct gggtgcagaa 60
gataactata ccctggtttc tcacctgatc gccaccgagt acctgaacta tgaggatggc 120
aaatttagca agagccgcgg cgtcggcgtt ttcggtgaca tggctcagga cacgggtatt 180
ccggcggaca tctggcgctt ctacctgctg tacattcgtc cggagggtca ggatagcgca 240
tttagctgga ccgacttgct gctgaagaat aatagcgagc tgttgaacaa tttgggtaac 300
tttatcaacc gtgcgggtat gtttgtgtcc aaattcttcg gcggttacgt cccggagatg 360
gttctgactc cggatgatca gcgtctgctg gcgcacgtca ccttggaatt gcagcactac 420
caccagctgc tggagaaggt ccgcatccgc gacgctctgc gtagcattct gacgatcagc 480
cgtcatggta atcaatatat ccaagttaac gaaccgtgga aacgtatcaa aggtagcgag 540
gcggaccgtc agcgcgcggg caccgtgacc ggcctggccg ttaatattgc ggcgctgttg 600
agcgtgatgc tgcagccgta tatgccgact gtgagcgcca ccatccaggc acagctgcaa 660
ctgccgccgc cagcttgcag cattctgctg accaatttcc tgtgcacctt gccggcaggc 720
catcaaattg gtacggtgtc tccactgttc cagaagctgg aaaacgacca aattgagtcc 780
ctgcgtcaac gttttggtgg tggtcaagcg aaaacgtcgc ctaaaccggc ggtggtcgaa 840
acggttacga ccgcaaaacc gcaacaaatc caggctctga tggatgaggt gaccaaacaa 900
ggcaatattg ttcgtgaact gaaggcccag aaagcagaca agaacgaggt cgccgcggaa 960
gtcgcaaaac tgctggattt gaagaaacag ctggcagttg cggaaggtaa gccgccggag 1020
gcgccgaagg gcaagaagaa gaaataatga ctcgag                           1056

<210> 175
<211> 978
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 175
gttgaagaac ctcgtgcaaa atacctgaac tatgaggacg gtaaattcag caagagccgc 60
ggtgttggtg tgtttggcga tatggcccag gacaccggta ttccggcgga catttggcgt 120
ttctatctgc tgtacattcg tccggaaggc caggattccg cattcagctg gaccgacctg 180
ctgctgaaga acaacagcga actgctgaac aacctgggta attttattaa tcgcgccggt 240
atgtttgttt ctaaattctt tggcggttat gttccggaga tggttctgac gccagatgat 300
cagcgtctgc tggcgcatgt tactttggaa ctgcagcact atcatcagtt gctggagaaa 360
gtccgcatcc gcgacgcgct gcgttcgatc ttgacgatca gccgccacgg taaccaatac 420
attcaagtga acgagccgtg gaaacgtatc aagggttctg aagcggaccg tcagcgtgca 480
ggcaccgtga ccggtctggc ggtgaatatc gcggcgttgt tgtccgtgat gctgcagccg 540
tacatgccga cggtgagcgc caccatccaa gcacaattgc agctgccgcc gccggcgtgc 600
agcatcctgc tgaccaattt tctgtgtacg ctgccggcgg gccaccaaat tggcaccgtc 660
agcccactgt tccaaaagct ggagaatgat cagattgaaa gcctgcgtca gcgtttcggc 720
ggcggtcaag ctaaaacgag ccctaagccg gccgtggtcg aaaccgtcac gaccgcaaaa 780
ccgcaacaga ttcaagccct gatggacgag gtcaccaaac agggcaacat cgtgcgtgag 840
ctgaaagcac aaaaggctga caagaatgag gttgcagcgg aagttgcgaa actgctggat 900
ctgaagaagc agctggcggt cgccgagggt aaaccgcctg aggctccgaa aggtaagaag 960
aagaaataat gactcgag                                               978

<210> 176
<211> 174
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Methionyl tRNA Synthetase
      polynucleotide

<400> 176
gacgaggtta ccaaacaggg taacatcgtg cgtgaactga aagcccaaaa ggctgacaag 60
aacgaggtcg cagctgaagt tgcgaaactg ttggatctga agaaacagct ggcggtggca 120
gaaggcaaac caccggaggc gccgaaaggt aagaagaaga aataatgact cgag       174
