                              Sequence Listing

<110> Genentech, Inc. et al.

<120> COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND 
      TREATMENT OF TUMOR

<130> P5042R1-WO


<150> US 61/330,698
<151> 2010-05-03

<160> 30

<210> 1
<211> 4078
<212> DNA
<213> Homo sapiens

<400> 1
 cggcaagatg ctgcccgtgt accaggaggt gaagcccaac ccgctgcagg 50

 acgcgaacct ctgctcacgc gtgttcttct ggtggctcaa tcccttgttt 100

 aaaattggcc ataaacggag attagaggaa gatgatatgt attcagtgct 150

 gccagaagac cgctcacagc accttggaga ggagttgcaa gggttctggg 200

 ataaagaagt tttaagagct gagaatgacg cacagaagcc ttctttaaca 250

 agagcaatca taaagtgtta ctggaaatct tatttagttt tgggaatttt 300

 tacgttaatt gaggaaagtg ccaaagtaat ccagcccata tttttgggaa 350

 aaattattaa ttattttgaa aattatgatc ccatggattc tgtggctttg 400

 aacacagcgt acgcctatgc cacggtgctg actttttgca cgctcatttt 450

 ggctatactg catcacttat atttttatca cgttcagtgt gctgggatga 500

 ggttacgagt agccatgtgc catatgattt atcggaaggc acttcgtctt 550

 agtaacatgg ccatggggaa gacaaccaca ggccagatag tcaatctgct 600

 gtccaatgat gtgaacaagt ttgatcaggt gacagtgttc ttacacttcc 650

 tgtgggcagg accactgcag gcgatcgcag tgactgccct actctggatg 700

 gagataggaa tatcgtgcct tgctgggatg gcagttctaa tcattctcct 750

 gcccttgcaa agctgttttg ggaagttgtt ctcatcactg aggagtaaaa 800

 ctgcaacttt cacggatgcc aggatcagga ccatgaatga agttataact 850

 ggtataagga taataaaaat gtacgcctgg gaaaagtcat tttcaaatct 900

 tattaccaat ttgagaaaga aggagatttc caagattctg agaagttcct 950

 gcctcagggg gatgaatttg gcttcgtttt tcagtgcaag caaaatcatc 1000

 gtgtttgtga ccttcaccac ctacgtgctc ctcggcagtg tgatcacagc 1050

 cagccgcgtg ttcgtggcag tgacgctgta tggggctgtg cggctgacgg 1100

 ttaccctctt cttcccctca gccattgaga gggtgtcaga ggcaatcgtc 1150

 agcatccgaa gaatccagac ctttttgcta cttgatgaga tatcacagcg 1200

 caaccgtcag ctgccgtcag atggtaaaaa gatggtgcat gtgcaggatt 1250

 ttactgcttt ttgggataag gcatcagaga ccccaactct acaaggcctt 1300

 tcctttactg tcagacctgg cgaattgtta gctgtggtcg gccccgtggg 1350

 agcagggaag tcatcactgt taagtgccgt gctcggggaa ttggccccaa 1400

 gtcacgggct ggtcagcgtg catggaagaa ttgcctatgt gtctcagcag 1450

 ccctgggtgt tctcgggaac tctgaggagt aatattttat ttgggaagaa 1500

 atacgaaaag gaacgatatg aaaaagtcat aaaggcttgt gctctgaaaa 1550

 aggatttaca gctgttggag gatggtgatc tgactgtgat aggagatcgg 1600

 ggaaccacgc tgagtggagg gcagaaagca cgggtaaacc ttgcaagagc 1650

 agtgtatcaa gatgctgaca tctatctcct ggacgatcct ctcagtgcag 1700

 tagatgcgga agttagcaga cacttgttcg aactgtgtat ttgtcaaatt 1750

 ttgcatgaga agatcacaat tttagtgact catcagttgc agtacctcaa 1800

 agctgcaagt cagattctga tattgaaaga tggtaaaatg gtgcagaagg 1850

 ggacttacac tgagttccta aaatctggta tagattttgg ctccctttta 1900

 aagaaggata atgaggaaag tgaacaacct ccagttccag gaactcccac 1950

 actaaggaat cgtaccttct cagagtcttc ggtttggtct caacaatctt 2000

 ctagaccctc cttgaaagat ggtgctctgg agagccaaga tacagagaat 2050

 gtcccagtta cactatcaga ggagaaccgt tctgaaggaa aagttggttt 2100

 tcaggcctat aagaattact tcagagctgg tgctcactgg attgtcttca 2150

 ttttccttat tctcctaaac actgcagctc aggttgccta tgtgcttcaa 2200

 gattggtggc tttcatactg ggcaaacaaa caaagtatgc taaatgtcac 2250

 tgtaaatgga ggaggaaatg taaccgagaa gctagatctt aactggtact 2300

 taggaattta ttcaggttta actgtagcta ccgttctttt tggcatagca 2350

 agatctctat tggtattcta cgtccttgtt aactcttcac aaactttgca 2400

 caacaaaatg tttgagtcaa ttctgaaagc tccggtatta ttctttgata 2450

 gaaatccaat aggaagaatt ttaaatcgtt tctccaaaga cattggacac 2500

 ttggatgatt tgctgccgct gacgttttta gatttcatcc agacattgct 2550

 acaagtggtt ggtgtggtct ctgtggctgt ggccgtgatt ccttggatcg 2600

 caataccctt ggttcccctt ggaatcattt tcatttttct tcggcgatat 2650

 tttttggaaa cgtcaagaga tgtgaagcgc ctggaatcta caactcggag 2700

 tccagtgttt tcccacttgt catcttctct ccaggggctc tggaccatcc 2750

 gggcatacaa agcagaagag aggtgtcagg aactgtttga tgcacaccag 2800

 gatttacatt cagaggcttg gttcttgttt ttgacaacgt cccgctggtt 2850

 cgccgtccgt ctggatgcca tctgtgccat gtttgtcatc atcgttgcct 2900

 ttgggtccct gattctggca aaaactctgg atgccgggca ggttggtttg 2950

 gcactgtcct atgccctcac gctcatgggg atgtttcagt ggtgtgttcg 3000

 acaaagtgct gaagttgaga atatgatgat ctcagtagaa agggtcattg 3050

 aatacacaga ccttgaaaaa gaagcacctt gggaatatca gaaacgccca 3100

 ccaccagcct ggccccatga aggagtgata atctttgaca atgtgaactt 3150

 catgtacagt ccaggtgggc ctctggtact gaagcatctg acagcactca 3200

 ttaaatcaca agaaaaggtt ggcattgtgg gaagaaccgg agctggaaaa 3250

 agttccctca tctcagccct ttttagattg tcagaacccg aaggtaaaat 3300

 ttggattgat aagatcttga caactgaaat tggacttcac gatttaagga 3350

 agaaaatgtc aatcatacct caggaacctg ttttgttcac tggaacaatg 3400

 aggaaaaacc tggatccctt taatgagcac acggatgagg aactgtggaa 3450

 tgccttacaa gaggtacaac ttaaagaaac cattgaagat cttcctggta 3500

 aaatggatac tgaattagca gaatcaggat ccaattttag tgttggacaa 3550

 agacaactgg tgtgccttgc cagggcaatt ctcaggaaaa atcagatatt 3600

 gattattgat gaagcgacgg caaatgtgga tccaagaact gatgagttaa 3650

 tacaaaaaaa aatccgggag aaatttgccc actgcaccgt gctaaccatt 3700

 gcacacagat tgaacaccat tattgacagc gacaagataa tggttttaga 3750

 ttcaggaaga ctgaaagaat atgatgagcc gtatgttttg ctgcaaaata 3800

 aagagagcct attttacaag atggtgcaac aactgggcaa ggcagaagcc 3850

 gctgccctca ctgaaacagc aaaacaggta tacttcaaaa gaaattatcc 3900

 acatattggt cacactgacc acatggttac aaacacttcc aatggacagc 3950

 cctcgacctt aactattttc gagacagcac tgtgaatcca accaaaatgt 4000

 caagtccgtt ccgaagcatt ttcaagggcg aattcgttta aacctgcagg 4050

 actagtccct ttagtgaggg  ttaattct 4078

<210> 2
<211> 1325
<212> PRT
<213> Homo sapiens

<400> 2
 Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp
   1               5                  10                  15

 Ala Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu
                  20                  25                  30

 Phe Lys Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr
                  35                  40                  45

 Ser Val Leu Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu
                  50                  55                  60

 Gln Gly Phe Trp Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala
                  65                  70                  75

 Gln Lys Pro Ser Leu Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys
                  80                  85                  90

 Ser Tyr Leu Val Leu Gly Ile Phe Thr Leu Ile Glu Glu Ser Ala
                  95                 100                 105

 Lys Val Ile Gln Pro Ile Phe Leu Gly Lys Ile Ile Asn Tyr Phe
                 110                 115                 120

 Glu Asn Tyr Asp Pro Met Asp Ser Val Ala Leu Asn Thr Ala Tyr
                 125                 130                 135

 Ala Tyr Ala Thr Val Leu Thr Phe Cys Thr Leu Ile Leu Ala Ile
                 140                 145                 150

 Leu His His Leu Tyr Phe Tyr His Val Gln Cys Ala Gly Met Arg
                 155                 160                 165

 Leu Arg Val Ala Met Cys His Met Ile Tyr Arg Lys Ala Leu Arg
                 170                 175                 180

 Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly Gln Ile Val
                 185                 190                 195

 Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val Thr Val
                 200                 205                 210

 Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala Val
                 215                 220                 225

 Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly
                 230                 235                 240

 Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly
                 245                 250                 255

 Lys Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp
                 260                 265                 270

 Ala Arg Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile
                 275                 280                 285

 Ile Lys Met Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr
                 290                 295                 300

 Asn Leu Arg Lys Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys
                 305                 310                 315

 Leu Arg Gly Met Asn Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile
                 320                 325                 330

 Ile Val Phe Val Thr Phe Thr Thr Tyr Val Leu Leu Gly Ser Val
                 335                 340                 345

 Ile Thr Ala Ser Arg Val Phe Val Ala Val Thr Leu Tyr Gly Ala
                 350                 355                 360

 Val Arg Leu Thr Val Thr Leu Phe Phe Pro Ser Ala Ile Glu Arg
                 365                 370                 375

 Val Ser Glu Ala Ile Val Ser Ile Arg Arg Ile Gln Thr Phe Leu
                 380                 385                 390

 Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg Gln Leu Pro Ser Asp
                 395                 400                 405

 Gly Lys Lys Met Val His Val Gln Asp Phe Thr Ala Phe Trp Asp
                 410                 415                 420

 Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser Phe Thr Val
                 425                 430                 435

 Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly Ala Gly
                 440                 445                 450

 Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro Ser
                 455                 460                 465

 His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln
                 470                 475                 480

 Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe
                 485                 490                 495

 Gly Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala
                 500                 505                 510

 Cys Ala Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu
                 515                 520                 525

 Thr Val Ile Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys
                 530                 535                 540

 Ala Arg Val Asn Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile
                 545                 550                 555

 Tyr Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ala Glu Val Ser
                 560                 565                 570

 Arg His Leu Phe Glu Leu Cys Ile Cys Gln Ile Leu His Glu Lys
                 575                 580                 585

 Ile Thr Ile Leu Val Thr His Gln Leu Gln Tyr Leu Lys Ala Ala
                 590                 595                 600

 Ser Gln Ile Leu Ile Leu Lys Asp Gly Lys Met Val Gln Lys Gly
                 605                 610                 615

 Thr Tyr Thr Glu Phe Leu Lys Ser Gly Ile Asp Phe Gly Ser Leu
                 620                 625                 630

 Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln Pro Pro Val Pro Gly
                 635                 640                 645

 Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu Ser Ser Val Trp
                 650                 655                 660

 Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly Ala Leu Glu
                 665                 670                 675

 Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu Glu Asn
                 680                 685                 690

 Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr Phe
                 695                 700                 705

 Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu
                 710                 715                 720

 Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu
                 725                 730                 735

 Ser Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn
                 740                 745                 750

 Gly Gly Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu
                 755                 760                 765

 Gly Ile Tyr Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile
                 770                 775                 780

 Ala Arg Ser Leu Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln
                 785                 790                 795

 Thr Leu His Asn Lys Met Phe Glu Ser Ile Leu Lys Ala Pro Val
                 800                 805                 810

 Leu Phe Phe Asp Arg Asn Pro Ile Gly Arg Ile Leu Asn Arg Phe
                 815                 820                 825

 Ser Lys Asp Ile Gly His Leu Asp Asp Leu Leu Pro Leu Thr Phe
                 830                 835                 840

 Leu Asp Phe Ile Gln Thr Leu Leu Gln Val Val Gly Val Val Ser
                 845                 850                 855

 Val Ala Val Ala Val Ile Pro Trp Ile Ala Ile Pro Leu Val Pro
                 860                 865                 870

 Leu Gly Ile Ile Phe Ile Phe Leu Arg Arg Tyr Phe Leu Glu Thr
                 875                 880                 885

 Ser Arg Asp Val Lys Arg Leu Glu Ser Thr Thr Arg Ser Pro Val
                 890                 895                 900

 Phe Ser His Leu Ser Ser Ser Leu Gln Gly Leu Trp Thr Ile Arg
                 905                 910                 915

 Ala Tyr Lys Ala Glu Glu Arg Cys Gln Glu Leu Phe Asp Ala His
                 920                 925                 930

 Gln Asp Leu His Ser Glu Ala Trp Phe Leu Phe Leu Thr Thr Ser
                 935                 940                 945

 Arg Trp Phe Ala Val Arg Leu Asp Ala Ile Cys Ala Met Phe Val
                 950                 955                 960

 Ile Ile Val Ala Phe Gly Ser Leu Ile Leu Ala Lys Thr Leu Asp
                 965                 970                 975

 Ala Gly Gln Val Gly Leu Ala Leu Ser Tyr Ala Leu Thr Leu Met
                 980                 985                 990

 Gly Met Phe Gln Trp Cys Val Arg Gln Ser Ala Glu Val Glu Asn
                 995                1000                1005

 Met Met Ile Ser Val Glu Arg Val Ile Glu Tyr Thr Asp Leu Glu
                1010                1015                1020

 Lys Glu Ala Pro Trp Glu Tyr Gln Lys Arg Pro Pro Pro Ala Trp
                1025                1030                1035

 Pro His Glu Gly Val Ile Ile Phe Asp Asn Val Asn Phe Met Tyr
                1040                1045                1050

 Ser Pro Gly Gly Pro Leu Val Leu Lys His Leu Thr Ala Leu Ile
                1055                1060                1065

 Lys Ser Gln Glu Lys Val Gly Ile Val Gly Arg Thr Gly Ala Gly
                1070                1075                1080

 Lys Ser Ser Leu Ile Ser Ala Leu Phe Arg Leu Ser Glu Pro Glu
                1085                1090                1095

 Gly Lys Ile Trp Ile Asp Lys Ile Leu Thr Thr Glu Ile Gly Leu
                1100                1105                1110

 His Asp Leu Arg Lys Lys Met Ser Ile Ile Pro Gln Glu Pro Val
                1115                1120                1125

 Leu Phe Thr Gly Thr Met Arg Lys Asn Leu Asp Pro Phe Asn Glu
                1130                1135                1140

 His Thr Asp Glu Glu Leu Trp Asn Ala Leu Gln Glu Val Gln Leu
                1145                1150                1155

 Lys Glu Thr Ile Glu Asp Leu Pro Gly Lys Met Asp Thr Glu Leu
                1160                1165                1170

 Ala Glu Ser Gly Ser Asn Phe Ser Val Gly Gln Arg Gln Leu Val
                1175                1180                1185

 Cys Leu Ala Arg Ala Ile Leu Arg Lys Asn Gln Ile Leu Ile Ile
                1190                1195                1200

 Asp Glu Ala Thr Ala Asn Val Asp Pro Arg Thr Asp Glu Leu Ile
                1205                1210                1215

 Gln Lys Lys Ile Arg Glu Lys Phe Ala His Cys Thr Val Leu Thr
                1220                1225                1230

 Ile Ala His Arg Leu Asn Thr Ile Ile Asp Ser Asp Lys Ile Met
                1235                1240                1245

 Val Leu Asp Ser Gly Arg Leu Lys Glu Tyr Asp Glu Pro Tyr Val
                1250                1255                1260

 Leu Leu Gln Asn Lys Glu Ser Leu Phe Tyr Lys Met Val Gln Gln
                1265                1270                1275

 Leu Gly Lys Ala Glu Ala Ala Ala Leu Thr Glu Thr Ala Lys Gln
                1280                1285                1290

 Val Tyr Phe Lys Arg Asn Tyr Pro His Ile Gly His Thr Asp His
                1295                1300                1305

 Met Val Thr Asn Thr Ser Asn Gly Gln Pro Ser Thr Leu Thr Ile
                1310                1315                1320

 Phe Glu Thr Ala Leu
                1325

<210> 3
<211> 132
<212> PRT
<213> Homo sapiens

<400> 3
 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu
   1               5                  10                  15

 Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val
                  20                  25                  30

 His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro
                  35                  40                  45

 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly
                  95                 100                 105

 Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val
                 110                 115                 120

 Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser
                 125                 130        

<210> 4
<211> 117
<212> PRT
<213> Homo sapiens

<400> 4
 Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly
   1               5                  10                  15

 Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr
                  20                  25                  30

 Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu
                  35                  40                  45

 Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val
                  50                  55                  60

 Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu
                  65                  70                  75

 Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys
                  80                  85                  90

 Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys
                  95                 100                 105

 Leu Thr Val Leu Gly Gln Pro Lys Ser Ser Pro Ser
                 110                 115        

<210> 5
<211> 124
<212> PRT
<213> Homo sapiens

<400> 5
 Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Glu Thr Val Thr Ile Thr Cys Arg Ser Ser Glu Asn Ile Tyr
                  20                  25                  30

 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Lys Ser Pro Gln
                  35                  40                  45

 Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile
                  65                  70                  75

 Tyr Ser Leu Gln Ser Ala Asp Phe Gly Ser Tyr Tyr Cys Gln His
                  80                  85                  90

 His Phe Gly Ser Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu
                  95                 100                 105

 Ser Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
                 110                 115                 120

 Ser Ser Glu Gln
                

<210> 6
<211> 158
<212> PRT
<213> Homo sapiens

<400> 6
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Asp Tyr Tyr Met Gln Trp Val Lys Gln Arg Thr Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Asn
                  50                  55                  60

 Ala Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr Gly Asn Gly
                  95                 100                 105

 Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
                 110                 115                 120

 Ser Ala Lys Thr Ala Ala Pro Ser Val Tyr Pro Leu Ala Pro Val
                 125                 130                 135

 Arg Gly Gly Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val
                 140                 145                 150

 Glu Gly Tyr Phe Pro Glu Pro Val
                 155            

<210> 7
<211> 155
<212> PRT
<213> Homo sapiens

<400> 7
 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser Leu Gly Glu Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr
                  50                  55                  60

 Asn Lys Lys Phe Lys Gly Lys Ala Ser Leu Thr Val Asp Lys Ser
                  65                  70                  75

 Ser Thr Thr Ala Tyr Met Asp Leu Asn Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Phe Cys Ala Arg Leu Gly Glu Met Ala Tyr Phe
                  95                 100                 105

 Asp Tyr Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Lys
                 110                 115                 120

 Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala
                 125                 130                 135

 Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
                 140                 145                 150

 Phe Pro Glu Pro Val
                 155

<210> 8
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8
 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu
                  50                  55                  60

 Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser
                  65                  70                  75

 Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Pro Thr Ser Asp Asp
                  80                  85                  90

 Ser Ala Val Tyr Phe Cys Thr Arg Glu Ala Ile Thr Ala Val His
                  95                 100                 105

 Phe Trp Gly His Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr
                 110                 115                 120

 Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr
                 125                 130                 135

 Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val
                

<210> 9
<211> 155
<212> PRT
<213> Homo sapiens

<400> 9
 Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr
                  20                  25                  30

 Thr Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Leu Gly Leu Ile Trp Gly Asp Gly Ser Ile Asn Tyr His
                  50                  55                  60

 Ser Ala Leu Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys
                  65                  70                  75

 Ser Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr
                  80                  85                  90

 Ala Thr Tyr Tyr Cys Ala Lys Gly Trp Gly Gly Leu Tyr Val Met
                  95                 100                 105

 Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ala Ser Ala Lys
                 110                 115                 120

 Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp
                 125                 130                 135

 Thr Thr Gly Ser Ser Val Thr Leu Gly Tyr Leu Val Lys Gly Tyr
                 140                 145                 150

 Phe Pro Glu Pro Val
                 155

<210> 10
<211> 16
<212> PRT
<213> Homo sapiens

<400> 10
 Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu
   1               5                  10                  15

 Asp
    

<210> 11
<211> 14
<212> PRT
<213> Homo sapiens

<400> 11
 Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn
                   5                  10                

<210> 12
<211> 11
<212> PRT
<213> Homo sapiens

<400> 12
 Arg Ser Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
                   5                  10    

<210> 13
<211> 7
<212> PRT
<213> Homo sapiens

<400> 13
 Lys Val Ser Asn Arg Phe Ser
                   5        

<210> 14
<211> 7
<212> PRT
<213> Homo sapiens

<400> 14
 Gly Thr Asn Asn Arg Ala Pro
                   5        

<210> 15
<211> 7
<212> PRT
<213> Homo sapiens

<400> 15
 Asn Ala Lys Thr Leu Ala Glu
                   5        

<210> 16
<211> 9
<212> PRT
<213> Homo sapiens

<400> 16
 Phe Gln Gly Ser His Val Pro Trp Thr
                   5                

<210> 17
<211> 9
<212> PRT
<213> Homo sapiens

<400> 17
 Ala Leu Trp Tyr Ser Asn His Trp Val
                   5                

<210> 18
<211> 13
<212> PRT
<213> Homo sapiens

<400> 18
 Gln His His Phe Gly Ser Pro Thr Phe Gly Gly Gly Thr
                   5                  10            

<210> 19
<211> 10
<212> PRT
<213> Homo sapiens

<400> 19
 Gly Phe Asn Ile Lys Asp Tyr Tyr Met Gln
                   5                  10

<210> 20
<211> 10
<212> PRT
<213> Homo sapiens

<400> 20
 Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Lys
                   5                  10

<210> 21
<211> 10
<212> PRT
<213> Homo sapiens

<400> 21
 Gly Tyr Ser Phe Thr Ser Tyr Trp Met Asn
                   5                  10

<210> 22
<211> 10
<212> PRT
<213> Homo sapiens

<400> 22
 Gly Phe Ser Leu Thr Thr Tyr Gly Val Ser
                   5                  10

<210> 23
<211> 18
<212> PRT
<213> Homo sapiens

<400> 23
 Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Asn Ala Pro Lys
   1               5                  10                  15

 Phe Gln Gly
            

<210> 24
<211> 18
<212> PRT
<213> Homo sapiens

<400> 24
 Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Lys Lys
   1               5                  10                  15

 Phe Lys Gly
            

<210> 25
<211> 18
<212> PRT
<213> Homo sapiens

<400> 25
 Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys
   1               5                  10                  15

 Phe Lys Asp
            

<210> 26
<211> 17
<212> PRT
<213> Homo sapiens

<400> 26
 Gly Leu Ile Trp Gly Asp Gly Ser Ile Asn Tyr His Ser Ala Leu
   1               5                  10                  15

 Ile Ser
        

<210> 27
<211> 14
<212> PRT
<213> Homo sapiens

<400> 27
 Ala Arg Glu Gly Tyr Tyr Gly Asn Gly Tyr Ala Met Asp Tyr
                   5                  10                

<210> 28
<211> 11
<212> PRT
<213> Homo sapiens

<400> 28
 Ala Arg Leu Gly Glu Met Ala Tyr Phe Asp Tyr
                   5                  10    

<210> 29
<211> 10
<212> PRT
<213> Homo sapiens

<400> 29
 Thr Arg Glu Ala Ile Thr Ala Val His Phe
                   5                  10

<210> 30
<211> 18
<212> PRT
<213> Homo sapiens

<400> 30
 Ala Lys Gly Trp Gly Gly Leu Tyr Val Met Asp Tyr Trp Gly Gln
   1               5                  10                  15

 Gly Thr Ser
            

