                         SEQUENCE LISTING

<110>  ABBOTT LABORATORIES
 
<120>  METHODS OF INHIBITING FIBROSIS USING ANTI-PAI-1 ANTIBODIES

<130>  117813-60420

<140>  PCT/US2011/034815
<141>  2011-05-02

<160>  249   

<170>  PatentIn version 3.5

<210>  1

<400>  1
000

<210>  2

<400>  2
000

<210>  3

<400>  3
000

<210>  4

<400>  4
000

<210>  5
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 01

<400>  5
caggtacagc tggtgcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  6
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 01

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 01

<400>  7
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cgctcgttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctataag gcctctagtt tagccagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 01

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 02

<400>  9
caggtacagc tggtgcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  10
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 02

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 02

<400>  11
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cactcgttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctataag gcctctagtt tagccagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtgatt atccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 02

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 03

<400>  13
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactat      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acagccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcc      360

tca                                                                    363


<210>  14
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 03

<400>  14

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 03

<400>  15
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cgctccttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctataag gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcgg cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  16
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 03

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 04

<400>  17
caggtacggc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccggggcag agtcacgatt accgcgaacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct actactgtgc gagagagaag      300

aggcagtggc tggaaggacg ctttgactac tggggccggg gcaccctggt caccgtctcg      360

agc                                                                    363


<210>  18
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 04

<400>  18

Gln Val Arg Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Ala Asn Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly Arg Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 04

<400>  19
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctattggaga cagaatcacc       60

atcacctgcc gggccagtga gggtatttat cactcgttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatccatagg gccactagtt tagccagtgg gaccccatca      180

aggttcggcg gcagtggatc tgggacggat ttcgctctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaact atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  20
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 04

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Arg Ala Thr Ser Leu Ala Ser Gly Thr Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 05

<400>  21
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta ctttttctac agcaaactac      180

gcacagaagt tccggggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  22
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 05

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Ser Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 05

<400>  23
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat caccagttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 05

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Gln 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 06

<400>  25
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  26
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 06

<400>  26

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 06

<400>  27
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagttacc       60

atcacctgcc gggccagtga gggtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcaga      300

gggaccaagc tggagatcaa g                                                321


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 06

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 07

<400>  29
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg ggtgggaggg atcatcccta cttttggcac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  30
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 07

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 07

<400>  31
gacatccaga tggcccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc cgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  32
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 07

<400>  32

Asp Ile Gln Met Ala Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 08

<400>  33
caggtacagc tggtgcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gctcagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag gtctgaggac acggccgtct attactgtgc gagagagagg      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  34
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 08

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  35
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 08

<400>  35
gacatccaga tgacccagtc cccatccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctataag gcctctagtt tagccagtgg ggtcccatca      180

aggttcagcg gcagtagatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccacttac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 08

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 09

<400>  37
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cttttgacac agcaaactac      180

gcacaaaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  38
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 09

<400>  38

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  39
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 09

<400>  39
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc aggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagt tggagatcaa a                                                321


<210>  40
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 09

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 10

<400>  41
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg agtccacgag cacagcctac      240

atggagttga gcagcttgag atctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  42
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 10

<400>  42

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 10

<400>  43
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagggtcgcc       60

atcacctgcc gggccagtga gggtatttat cactccttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaggc tggagatcaa a                                                321


<210>  44
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 10

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 11

<400>  45
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctggat gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt cactgtttcg      360

agt                                                                    363


<210>  46
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 11

<400>  46

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 11

<400>  47
gacatccaga tgatccagtc cccatccttc ctgtctgcat ctactggaga cagagtcacc       60

atcacctgcc aggccagtga gggtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  48
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 11

<400>  48

Asp Ile Gln Met Ile Gln Ser Pro Ser Phe Leu Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Gly Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 12

<400>  49
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggggg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttcctac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  50
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 12

<400>  50

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Pro Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  51
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 12

<400>  51
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca acagaagcca      120

gggaaagccc ctaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagcggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  52
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 12

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  53
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 13

<400>  53
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcgacctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  54
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 13

<400>  54

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asp Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 13

<400>  55
gacatccaaa tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cactcgttgg cctggtatca gcagaagcca      120

gggaaagccc caaaacttct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  56
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 13

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 14

<400>  57
caggtacagc tgcaacagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcg      360

agt                                                                    363


<210>  58
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 14

<400>  58

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 14

<400>  59
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattgggga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactttca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  60
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 14

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  61
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 15

<400>  61
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttccggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  62
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 15

<400>  62

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  63
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 15

<400>  63
gacatccaga tggctcaatc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagccg      120

gggaaagccc ctaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacggac ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaact atccgctcac tttcggcgga      300

gggaccaagc tggagatcag a                                                321


<210>  64
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 15

<400>  64

Asp Ile Gln Met Ala Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  65
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 16

<400>  65
caggtacagc tggtgcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccca cttttggtac agcaaactac      180

gcacagaagt ttcagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag gtctgaggac acggccgtct attactgcgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  66
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 16

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  67
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 16

<400>  67
gacatccaga tgacccagtc tccatctacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacctgcc gggccagtga gagtatttat cactcgttgg cctggtatca gcagaagcca      120

gggaaggccc ctaaactcct gatctataag gcctctagtt tagccagtgg ggtcccatca      180

aggttcagcg gcagtagatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  68
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 16

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr His Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 17

<400>  69
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaagtc       60

tcctgcaagg cttctggagg cacctttagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta ctttcggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  70
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 17

<400>  70

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  71
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 17

<400>  71
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctatcggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  72
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 17

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 18

<400>  73
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagc tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  74
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 18

<400>  74

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  75
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 18

<400>  75
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgcgttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgatttcg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  76
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 18

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  77
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 19

<400>  77
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttccggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tttttgatac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagagg      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  78
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 19

<400>  78

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  79
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 19

<400>  79
gacatccgga tgacccagtc cccgtccttc ctgtctgcgt ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaact atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  80
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 19

<400>  80

Asp Ile Arg Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  81
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 20

<400>  81
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc agtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  82
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 20

<400>  82

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  83
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 20

<400>  83
gacatccaga tgacccagtc cccatccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc caaagctcct gatctatagg gcctctagtt tagccagtgg ggtcccatca      180

aggttcagcg gcagtagatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagcgatt atccgctcac tttcggcggg      300

gggaccaagg tggagatcaa a                                                321


<210>  84
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 20

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  85
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 21

<400>  85
ccagtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg taccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct actactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  86
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 21

<400>  86

Pro Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 21

<400>  87
gacatccaga tggcccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagcggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  88
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 21

<400>  88

Asp Ile Gln Met Ala Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  89
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 22

<400>  89
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc ggctacgcta tcagctgggt gcgacaggcc      120

cctggacagg ggctcgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

tcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  90
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 22

<400>  90

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  91
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 22

<400>  91
gacatccaga tgacccagtc cctatccttc ctgtctgcat ctattgggga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgccttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  92
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 22

<400>  92

Asp Ile Gln Met Thr Gln Ser Leu Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 23

<400>  93
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta ctttcggtac agcaaactac      180

gcacagaagt tccagagcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtccgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  94
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 23

<400>  94

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  95
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 23

<400>  95
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagcga gggtatttat cacagcttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  96
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 23

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  97
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 24

<400>  97
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg taccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccta cttttgtgac agcaaactac      180

gcacagaagt tccagggcag agtctcgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  98
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 24

<400>  98

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Val Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  99
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 24

<400>  99
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacgcgttgg cctggtatca gcagaagccg      120

gggaaagccc caaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  100
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 24

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  101
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 25

<400>  101
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagagg      300

aggcagtggc tggaaggaca ctttgactac tggggccagg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  102
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 25

<400>  102

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  103
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 25

<400>  103
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gagtatttat cacgagttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctataag gcctctagtt tagccagcgg ggccccatca      180

aggttcagcg gcagtgggtc tgggacagct ttcactctta ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  104
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 25

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr His Glu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  105
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 26

<400>  105
caggtacagc tgcagcagtc cggggctgag gtgaagaagc ctggcacttc ggtgaaggtc       60

tcctgcaagg cttccggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta ttttcggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcg      360

agt                                                                    363


<210>  106
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 26

<400>  106

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  107
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 26

<400>  107
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacacgttgg cctggtatca gcagaagcca      120

gggaaagccc caaagctcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagtag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  108
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 26

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Thr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  109
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  Antibody 27

<400>  109
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg cgccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcggcctgag gtctgaggac acggccgtct attactgtgc gagagagaag      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccccggt caccgtctcc      360

tca                                                                    363


<210>  110
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Antibody 27

<400>  110

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  111
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Antibody 27

<400>  111
gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctatagg gcctctagtt tagccagtgg ggccccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tatagtaatt atccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210>  112
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Antibody 27

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  113
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Antibody 1-27

<400>  113

Ser Tyr Ala Ile Ser 
1               5   


<210>  114
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Antibody 19

<400>  114

Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Antibodies 1, 2, 3, 5-7, 10, 12-18, 20-24, 26, and 27

<400>  115

Glu Lys Arg Gln Trp Leu Glu Gly His Phe Asp Tyr 
1               5                   10          


<210>  116

<400>  116
000

<210>  117
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Antibodies 1, 2, 3, 8, 16 and 25

<400>  117

Lys Ala Ser Ser Leu Ala Ser 
1               5           


<210>  118
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Antibodies 1, 3-19, and 21-27

<400>  118

Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  119
<211>  402
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(402)
<223>  PAI-1

<400>  119

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  120
<211>  402
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(402)
<223>  PAI-1

<400>  120

Met Gln Met Ser Ser Ala Leu Thr Cys Leu Thr Leu Gly Leu Val Leu 
1               5                   10                  15      


Val Phe Gly Lys Gly Phe Ala Ser Pro Leu Pro Glu Ser His Thr Ala 
            20                  25                  30          


Gln Gln Ala Thr Asn Phe Gly Val Lys Val Phe Gln His Val Val Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ser Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Ala Gly Lys Thr Arg Gln Gln 
65                  70                  75                  80  


Ile Gln Asp Ala Met Gly Phe Asn Ile Ser Glu Arg Gly Thr Ala Pro 
                85                  90                  95      


Ala Leu Arg Lys Leu Ser Lys Glu Leu Met Gly Ser Trp Asn Lys Asn 
            100                 105                 110         


Glu Ile Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Glu Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Lys Leu Phe Arg Thr Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Glu Arg His Thr Lys Gly Met Ile Ser Asp Leu Leu Ala 
                165                 170                 175     


Lys Gly Ala Val Asn Glu Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Leu Glu Ala Ser Thr His 
        195                 200                 205             


Gln Arg Leu Phe His Lys Ser Asp Gly Ser Thr Ile Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Asn Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Glu Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Glu Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Phe Glu Lys Asp Val Pro Leu Ser Ala 
            260                 265                 270         


Ile Thr Asn Ile Leu Asp Ala Glu Leu Ile Arg Gln Trp Lys Ser Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Ile Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Gly Pro Leu Glu Lys Leu Gly Met Thr Asp 
305                 310                 315                 320 


Ile Phe Ser Ser Thr Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Gln Leu Ser Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Ile Leu Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Thr Glu Met Val Leu Asp Arg Ser Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Glu Thr Ile Leu Phe Met Gly Gln Leu Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  121
<211>  402
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(402)
<223>  PAI-1

<400>  121

Met Gln Met Ser Ser Ala Leu Ala Cys Leu Ile Leu Gly Leu Val Leu 
1               5                   10                  15      


Val Ser Gly Lys Gly Phe Ala Leu Pro Leu Arg Glu Ser His Thr Ala 
            20                  25                  30          


His Gln Ala Thr Asp Phe Gly Val Lys Val Phe Gln Gln Val Val Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ser Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Met Thr Thr Ala Gly Lys Thr Arg Arg Gln 
65                  70                  75                  80  


Ile Gln Asp Ala Met Gly Phe Lys Val Asn Glu Lys Gly Thr Ala His 
                85                  90                  95      


Ala Leu Arg Gln Leu Ser Lys Glu Leu Met Gly Pro Trp Asn Lys Asn 
            100                 105                 110         


Glu Ile Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Glu Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Lys Leu Phe Gln Thr Met Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Glu Arg His Thr Lys Gly Met Ile Asn Asp Leu Leu Ala 
                165                 170                 175     


Lys Gly Ala Val Asp Glu Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Ser Gly Gln Trp Lys Thr Pro Phe Leu Glu Ala Ser Thr His 
        195                 200                 205             


Gln Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Ser Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly Leu Glu Tyr Asp Val Val Glu Leu Pro Tyr Gln Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Phe Glu Lys Asp Val His Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Asp Ala Glu Leu Ile Arg Gln Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Ile Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Gly Pro Leu Glu Lys Leu Gly Met Pro Asp 
305                 310                 315                 320 


Met Phe Ser Ala Thr Leu Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Gln Leu Ser Val Ala Gln Ala Leu Gln Lys Val Arg Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Phe Val Ile Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Thr Glu Met Val Ile Asp Arg Ser Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Glu Thr Ile Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Ser 
        


<210>  122
<211>  402
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<222>  (1)..(402)
<223>  PAI-1

<400>  122

Met Gln Met Ser Pro Ala Leu Ala Cys Leu Val Leu Gly Leu Ala Phe 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Thr Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Arg Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Leu Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Ala Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asp Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly His Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asn Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Gln Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asn Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  123
<211>  400
<212>  PRT
<213>  Canis familiaris


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  PAI-1

<400>  123

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Tyr Ser Tyr Gln Thr Arg Ala Ala Gly Leu 
            20                  25                  30          


Ala Thr Asp Phe Gly Val Lys Val Phe Gln Glu Val Ala Arg Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Met Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Ala Gly Glu Thr Cys Arg Gln Ile Gln 
65                  70                  75                  80  


Glu Ala Met Gln Phe Gln Ile Asp Glu Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg Gln Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val His 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Thr Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Val Asn Asp Trp 
145                 150                 155                 160 


Val Lys Arg His Thr Lys Gly Met Ile Gly Asn Leu Leu Gly Arg Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Met Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Glu Ser Gly Thr His His Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Ser Thr Pro Ser Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Asp Ala Gln Leu Ile Ser Gln Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Gln Leu Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asn Leu Arg Arg Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Pro Asn Leu Ala Asp Phe Ser Ser Leu Ser Asn Gln Glu Val Leu 
                325                 330                 335     


Tyr Val Ser Arg Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Ile Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  124
<211>  379
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(379)
<223>  Mature human PAI-1

<400>  124

Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly 
1               5                   10                  15      


Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val 
            20                  25                  30          


Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu 
        35                  40                  45              


Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala Met Gly Phe 
    50                  55                  60                  


Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu Arg His Leu Tyr Lys 
65                  70                  75                  80  


Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala 
                85                  90                  95      


Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His 
            100                 105                 110         


Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu 
        115                 120                 125             


Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr 
    130                 135                 140                 


Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val Asp Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys 
                165                 170                 175     


Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser 
            180                 185                 190         


Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe 
        195                 200                 205             


Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu 
    210                 215                 220                 


Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro 
225                 230                 235                 240 


Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala 
                245                 250                 255     


Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr Arg Leu Pro Arg Leu 
            260                 265                 270         


Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys 
        275                 280                 285             


Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala 
    290                 295                 300                 


Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu His Val Ala Gln Ala 
305                 310                 315                 320 


Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser 
                325                 330                 335     


Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met Ala Pro Glu Glu Ile 
            340                 345                 350         


Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly 
        355                 360                 365             


Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
    370                 375                 


<210>  125
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  125

Cys Gly His Tyr Tyr Asp Ile Cys 
1               5               


<210>  126
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  126

Cys Gly His Tyr Tyr Asp Cys Gly His Tyr Asp Cys 
1               5                   10          


<210>  127
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  127

Cys Gly His Tyr Tyr Asp Gly Cys Gly Gly His Tyr Asp Gly Cys 
1               5                   10                  15  


<210>  128
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  128

Cys Gly His Tyr Tyr Asp Cys Asn Tyr Thr Glu Phe Cys 
1               5                   10              


<210>  129
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  129

Cys Gly His Tyr Tyr Asp Ile Leu Cys 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  130

Cys Asp Gly His Tyr Tyr Asp Ile Cys 
1               5                   


<210>  131
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  131

Cys Asn Tyr Thr Glu Phe Cys Gly His Tyr Tyr Asp Cys 
1               5                   10              


<210>  132
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  132

Cys Arg Asn Val Val Phe Ser Pro Tyr Gly Cys Ala Ser Val Leu Ala 
1               5                   10                  15      


Met Leu Gln Leu Cys 
            20      


<210>  133
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  133

Cys Val Val Phe Ser Pro Tyr Gly Val Ala Cys Val Leu Ala Met Leu 
1               5                   10                  15      


Gln Leu Thr Thr Cys 
            20      


<210>  134
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  134

Cys Gly His Tyr Tyr Asp Cys Gly His Tyr Tyr Asp Cys 
1               5                   10              


<210>  135
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  135

Cys Gly His Tyr Tyr Asp Gly Cys Gly Gly His Tyr Tyr Asp Gly Cys 
1               5                   10                  15      


<210>  136
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  136

Cys Arg Asn Val Val Phe Ser Pro Tyr Gly Cys Ala Ser Val Leu Ala 
1               5                   10                  15      


Met Gln Leu Cys 
            20  


<210>  137
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  137

Cys His Tyr Tyr Asp Ile Leu Glu Leu Cys 
1               5                   10  


<210>  138
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  138

Cys Tyr Tyr Asp Ile Leu Glu Leu Cys 
1               5                   


<210>  139
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  139

Cys Tyr Tyr Asp Ile Leu Glu Cys 
1               5               


<210>  140
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  140

Cys Phe Asn Tyr Thr Glu Phe Thr Thr Cys Gly His Tyr Tyr Asp Ile 
1               5                   10                  15      


Leu Glu Leu Cys 
            20  


<210>  141
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  141

Cys His Tyr Tyr Asp Ile Leu Cys 
1               5               


<210>  142
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  142

Cys Gly Ala Val Asp Gln Leu Thr Arg Leu Cys Leu Val Asn Ala Leu 
1               5                   10                  15      


Tyr Phe Asn Gly Cys 
            20      


<210>  143
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  143

Cys Gln Thr Asn Lys Phe Asn Tyr Cys Thr Arg Leu Pro Arg Leu Leu 
1               5                   10                  15      


Cys 
    


<210>  144
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  144

Cys His Tyr Tyr Asp Ile Leu Glu Cys 
1               5                   


<210>  145
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  145

Cys Glu Phe Thr Thr Cys Gly His Tyr Tyr Asp Ile Leu Glu Cys 
1               5                   10                  15  


<210>  146
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  146

Cys Leu Phe Val Val Arg His Asn Pro Thr Cys Thr Val Leu Phe Met 
1               5                   10                  15      


Gly Gln Val Met Cys 
            20      


<210>  147
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  147

Cys Gly His Tyr Tyr Asp Ile Leu Glu Cys 
1               5                   10  


<210>  148
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  148

Cys Gln Thr Asn Lys Phe Asn Tyr Cys Thr Arg Leu Pro Arg Leu Cys 
1               5                   10                  15      


<210>  149
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  149

Cys Asn Val Val Phe Ser Pro Tyr Gly Val Cys Ser Val Leu Ala Met 
1               5                   10                  15      


Leu Gln Leu Thr Cys 
            20      


<210>  150
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  150

Cys Gly His Tyr Tyr Asp Ile Leu Glu Leu Cys 
1               5                   10      


<210>  151
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  151

Cys Thr Asn Lys Phe Asn Tyr Cys Thr Arg Leu Pro Arg Leu Cys 
1               5                   10                  15  


<210>  152
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  152

Cys Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu Cys 
1               5                   10                  


<210>  153
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  153

Cys Gln Thr Asn Lys Phe Asn Tyr Thr Glu Cys Asn Met Thr Arg Leu 
1               5                   10                  15      


Pro Cys 
        


<210>  154
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  154

Cys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Cys Gly His Tyr Tyr Asp 
1               5                   10                  15      


Ile Leu Glu Leu Cys 
            20      


<210>  155
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Derived from human PAI-1 sequence SEQ ID NO: 
       124

<400>  155

Cys Thr Asn Lys Phe Asn Tyr Cys Thr Arg Leu Pro Arg Leu Leu Val 
1               5                   10                  15      


Cys 
    


<210>  156
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  156

Gly His Tyr Tyr Asp 
1               5   


<210>  157
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  157

Gln Thr Asn Lys Phe Asn Tyr 
1               5           


<210>  158
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  158

Thr Arg Leu Pro Arg Leu Leu 
1               5           


<210>  159
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  HCDR2 of Antibody 22

<400>  159

Gly Tyr Ala Ile Ser 
1               5   


<210>  160
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibodies 01, 11, 26

<400>  160

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  161
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibodies 02, 03, 06..08, 10, 13..17, 20, 21, 25, 27

<400>  161

Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 04

<400>  162

Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  163
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 05

<400>  163

Gly Ile Ile Pro Thr Phe Ser Thr Ala Asn Tyr Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  164
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 09

<400>  164

Gly Ile Ile Pro Ala Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  165
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 12

<400>  165

Gly Ile Ile Pro Thr Phe Pro Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  166
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 18

<400>  166

Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 22

<400>  167

Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  168
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 23

<400>  168

Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Ser 
    


<210>  169
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  HCDR2 of Antibody 24

<400>  169

Gly Ile Ile Pro Thr Phe Val Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  170
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  HCDR3 of Antibody 04

<400>  170

Glu Lys Arg Gln Trp Leu Glu Gly Arg Phe Asp Tyr 
1               5                   10          


<210>  171
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  HCDR3 of Antibodies 08, 19, 25

<400>  171

Glu Arg Arg Gln Trp Leu Glu Gly His Phe Asp Tyr 
1               5                   10          


<210>  172
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibodies 01, 03

<400>  172

Arg Ala Ser Glu Gly Ile Tyr Arg Ser Leu Ala 
1               5                   10      


<210>  173
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibodies 02, 04, 10, 13, 23

<400>  173

Arg Ala Ser Glu Gly Ile Tyr His Ser Leu Ala 
1               5                   10      


<210>  174
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibody 05

<400>  174

Arg Ala Ser Glu Gly Ile Tyr His Gln Leu Ala 
1               5                   10      


<210>  175
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibodies 06, 07, 17, 19, 20

<400>  175

Arg Ala Ser Glu Gly Ile Tyr His Glu Leu Ala 
1               5                   10      


<210>  176
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibodies 08, 12, 14, 15, 21, 27

<400>  176

Arg Ala Ser Glu Gly Ile Tyr His Asn Leu Ala 
1               5                   10      


<210>  177
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibody 09

<400>  177

Gln Ala Ser Glu Gly Ile Tyr His Asn Leu Ala 
1               5                   10      


<210>  178
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibody 11

<400>  178

Gln Ala Ser Glu Gly Ile Tyr His Glu Leu Ala 
1               5                   10      


<210>  179
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibody 16

<400>  179

Arg Ala Ser Glu Ser Ile Tyr His Ser Leu Ala 
1               5                   10      


<210>  180
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibodies 18, 22, 24

<400>  180

Arg Ala Ser Glu Gly Ile Tyr His Ala Leu Ala 
1               5                   10      


<210>  181
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibody 25

<400>  181

Arg Ala Ser Glu Ser Ile Tyr His Glu Leu Ala 
1               5                   10      


<210>  182
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  LCDR1 of Antibody 26

<400>  182

Arg Ala Ser Glu Gly Ile Tyr His Thr Leu Ala 
1               5                   10      


<210>  183
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LCDR2 of Antibody 04

<400>  183

Arg Ala Thr Ser Leu Ala Ser 
1               5           


<210>  184
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LCDR2 of Antibodies 05..07, 09..15, 17..24, 26, 27

<400>  184

Arg Ala Ser Ser Leu Ala Ser 
1               5           


<210>  185
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LCDR3 of Antibody 02, 20

<400>  185

Gln Gln Tyr Ser Asp Tyr Pro Leu Thr 
1               5                   


<210>  186
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LCDR3 of Antibody 08

<400>  186

Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  187
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  HCDR1 of Antibody 08

<400>  187

Ser Tyr Ala Ile Ser 
1               5   


<210>  188
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Changed motif in R271S mutant PAI-1

<400>  188

Thr Arg Leu Pro Ser Leu Leu 
1               5           


<210>  189
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: R271S mutant PAI-1

<400>  189

Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly 
1               5                   10                  15      


Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val 
            20                  25                  30          


Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu 
        35                  40                  45              


Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln Ala Ala Met Gly Phe 
    50                  55                  60                  


Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu Arg His Leu Tyr Lys 
65                  70                  75                  80  


Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala 
                85                  90                  95      


Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His 
            100                 105                 110         


Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu 
        115                 120                 125             


Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr 
    130                 135                 140                 


Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly Ala Val Asp Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly Gln Trp Lys 
                165                 170                 175     


Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser 
            180                 185                 190         


Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe 
        195                 200                 205             


Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu 
    210                 215                 220                 


Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met Phe Ile Ala Ala Pro 
225                 230                 235                 240 


Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala 
                245                 250                 255     


Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr Arg Leu Pro Ser Leu 
            260                 265                 270         


Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys 
        275                 280                 285             


Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala 
    290                 295                 300                 


Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu His Val Ala Gln Ala 
305                 310                 315                 320 


Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser 
                325                 330                 335     


Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met Ala Pro Glu Glu Ile 
            340                 345                 350         


Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly 
        355                 360                 365             


Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
    370                 375                 


<210>  190
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  Stable form of human PAI-1

<400>  190

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  191
<211>  400
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: R292S mutant of stable form of human PAI-1

<400>  191

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Ser Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  192
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  192

Leu Pro Arg Leu 
1               


<210>  193
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  193

Arg Met Ala Pro Glu Glu 
1               5       


<210>  194
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Y210N stable mutant human PAI-1

<400>  194

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Asn Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  195
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  E212V stable mutant human PAI-1

<400>  195

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Val Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  196
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  Y220S stable mutant human PAI-1

<400>  196

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Ser Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Lys 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  197
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  Y241S stable mutant human PAI-1

<400>  197

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Ser Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  198
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  R271S stable mutant human PAI-1

<400>  198

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Ser Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  199
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  Y220S T267K stable mutant human PAI-1

<400>  199

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Ser Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Lys 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  200
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  cloned HIS-tagged wild type PAI-1

<400>  200

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly Lys Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  201
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  HIS tagged stable PAI-1

<400>  201

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His His Pro Pro Ser Tyr Val Ala His Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln Ile Gln 
65                  70                  75                  80  


Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp 
145                 150                 155                 160 


Val Lys Thr His Thr Lys Gly Met Ile Ser His Leu Leu Gly Thr Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu Pro Leu 
                325                 330                 335     


His Val Ala Leu Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Ile Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  202
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer HPAI1Nde

<400>  202
ctctcatatg gttcaccatc ccccatccta                                        30


<210>  203
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer HPAI1XhoI

<400>  203
acacctcgag tcagggttcc atcacttg                                          28


<210>  204
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer N150HK154T

<400>  204
ggtatgatca gccacttgct tgggacagga gccgtggacc                             40


<210>  205
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer Q319L

<400>  205
ctccacgtcg cgctggcgct gcagaaag                                          28


<210>  206
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer M354I

<400>  206
ccgaggagat catcatcgac agacccttcc                                        30


<210>  207
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer Y220S

<400>  207
acgcccgatg gccattccta cgacatcctg ga                                     32


<210>  208
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer Y241S

<400>  208
tcattgctgc cccttctgaa aaagaggtgc c                                      31


<210>  209
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer E212V

<400>  209
agttcaacta tactgtgttc accacgcccg a                                      31


<210>  210
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer R271S

<400>  210
atgaccaggc tgcccagcct cctggttctg c                                      31


<210>  211
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer T267K

<400>  211
ggaaaggcaa catgaaaagg ctgccccgcc t                                      31


<210>  212
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer Y210N

<400>  212
accaacaagt tcaacaatac tgagttcacc                                        30


<210>  213
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  213

Gly Ile Ile Xaa Xaa Phe Xaa Gly Thr Ala Asn 
1               5                   10      


<210>  214
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  214

Glu Xaa Arg Xaa Trp Leu Glu Gly 
1               5               


<210>  215
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be Asn or Asp

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  215

Tyr Ser Xaa Tyr Xaa Leu 
1               5       


<210>  216
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is a neutral amino acid residue

<400>  216

Xaa Tyr Ala Ile Ser 
1               5   


<210>  217
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid chosen from Ser, Thr, Gly, Ala, Val, Leu, 
       and Ile

<400>  217

Xaa Tyr Ala Ile Ser 
1               5   


<210>  218
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid chosen from Ser and Gly

<400>  218

Xaa Tyr Ala Ile Ser 
1               5   


<210>  219
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is a neutral amino acid residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is a neutral or acidic amino acid residue

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is a neutral amino acid residue

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is a neutral amino residue

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is a neutral or basic amino acid residue

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa is a neutral amino acid residue

<400>  219

Gly Ile Ile Pro Xaa Phe Xaa Thr Ala Asn Tyr Xaa Gln Lys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  220
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is a basic amino acid residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is a basic amino acid residue

<400>  220

Glu Xaa Arg Gln Trp Leu Glu Gly Xaa Phe Asp Tyr 
1               5                   10          


<210>  221
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an amino acid chosen from Ile, Ser, Thr, Gly, Ala, Val, 
       and Leu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is an amino acid chosen from Asp, Asn, Glu, Gln, Gly, Ala, 
       Val, Leu, Ile, Ser, Thr, and Pro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is an amino acid chosen from Ala, Ser, Thr, Gly, Val, Leu, 
       and Ile

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is an amino acid chosen from Phe, Leu, Ile, Ala, Ser, Thr, 
       Gly, Ala, and Val

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is an amino acid chosen from Gln, Asn, Arg, Lys, and His

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa is an amino acid chosen from Gly, Ser, Thr, Ala, Val, Leu, 
       and Ile

<400>  221

Gly Ile Ile Pro Xaa Phe Xaa Thr Ala Asn Tyr Xaa Gln Lys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  222
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is an amino acid chosen from Lys, Arg, and His

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid chosen from Lys, Arg, and His

<400>  222

Glu Xaa Arg Gln Trp Leu Glu Gly Xaa Phe Asp Tyr 
1               5                   10          


<210>  223
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid chosen from Arg, Lys, His, Gln, and Asn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an amino acid chosen from Gly, Ser, Thr, Ala, Val, Leu, 
       and Ile

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is an amino acid chosen from Lys, Arg, and His

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid chosen from Asp, Glu, Asn, and Gln

<400>  223

Xaa Ala Ser Glu Xaa Ile Tyr Xaa Xaa Leu Ala 
1               5                   10      


<210>  224
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid chosen from Lys, Arg, and His

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is an amino acid chosen from Gly, Ser, Thr, Ala, Val, Leu, 
       and Ile

<400>  224

Xaa Ala Xaa Ser Leu Ala Ser 
1               5           


<210>  225
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an amino acid chosen from Asn, Asp, Glu, and Gln

<400>  225

Gln Gln Tyr Ser Xaa Tyr Pro Leu Thr 
1               5                   


<210>  226
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is a basic or neutral amino acid residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is a neutral amino acid residue

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is a basic amino acid residue

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an acidic or neutral amino acid residue

<400>  226

Xaa Ala Ser Glu Xaa Ile Tyr Xaa Xaa Leu Ala 
1               5                   10      


<210>  227
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is a basic amino acid residue

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is a neutral amino acid residue

<400>  227

Xaa Ala Xaa Ser Leu Ala Ser 
1               5           


<210>  228
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an acidic or neutral amino acid residue

<400>  228

Gln Gln Tyr Ser Xaa Tyr Pro Leu Thr 
1               5                   


<210>  229
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an amino acid chosen from Ile, Thr, and Ala

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is an amino acid chosen from Asp, Gly, Val, Ser, and Pro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is an amino acid chosen from Ala and Ser

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is an amino acid chosen from Phe and Leu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is an amino acid chosen from Gln and Arg

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa is an amino acid chosen from Gly and Ser

<400>  229

Gly Ile Ile Pro Xaa Phe Xaa Thr Ala Asn Tyr Xaa Gln Lys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  230
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is an amino acid chosen from Lys and Arg

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid chosen from Arg, and His

<400>  230

Glu Xaa Arg Gln Trp Leu Glu Gly Xaa Phe Asp Tyr 
1               5                   10          


<210>  231
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid chosen from Arg and Gln

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an amino acid chosen from Gly and Ser

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is an amino acid chosen from Arg and His

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid chosen from Glu, Asn, Gln, Ser, Thr, Trp, 
       Phe, and Ala

<400>  231

Xaa Ala Ser Glu Xaa Ile Tyr Xaa Xaa Leu Ala 
1               5                   10      


<210>  232
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid chosen from Lys and Arg

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is an amino acid chosen from Ser and Thr

<400>  232

Xaa Ala Xaa Ser Leu Ala Ser 
1               5           


<210>  233
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is an amino acid chosen from Asn and Asp

<400>  233

Gln Gln Tyr Ser Xaa Tyr Pro Leu Thr 
1               5                   


<210>  234
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is a basic amino acid residue

<400>  234

Xaa Ala Ser Ser Leu Ala Ser 
1               5           


<210>  235
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is a neutral amino acid residue

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is an acidic or neutral amino acid residue

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is a basic or neutral amino acid residue

<400>  235

Gly Ile Ile Pro Xaa Phe Xaa Thr Ala Asn Tyr Ala Gln Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  236
<211>  400
<212>  PRT
<213>  Canis familiaris


<220>
<221>  misc_feature
<223>  Dog PAI-1 amino acid sequence

<400>  236

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Tyr Ser Tyr Gln Thr Arg Ala Ala Gly Leu 
            20                  25                  30          


Ala Thr Asp Phe Gly Val Lys Val Phe Gln Glu Val Ala Arg Ala Ser 
        35                  40                  45              


Lys Asp Arg Asn Met Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu 
    50                  55                  60                  


Ala Met Leu Gln Leu Thr Thr Ala Gly Glu Thr Cys Arg Gln Ile Gln 
65                  70                  75                  80  


Glu Ala Met Gln Phe Gln Ile Asp Glu Lys Gly Met Ala Pro Ala Leu 
                85                  90                  95      


Arg Gln Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp Glu Ile 
            100                 105                 110         


Ser Thr Ala Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu Val His 
        115                 120                 125             


Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Thr Thr Val Lys Gln 
    130                 135                 140                 


Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Val Asn Asp Trp 
145                 150                 155                 160 


Val Lys Arg His Thr Lys Gly Met Ile Gly Asn Leu Leu Gly Arg Gly 
                165                 170                 175     


Ala Val Asp Gln Leu Thr Arg Leu Met Leu Val Asn Ala Leu Tyr Phe 
            180                 185                 190         


Asn Gly Gln Trp Lys Thr Pro Phe Pro Glu Ser Gly Thr His His Arg 
        195                 200                 205             


Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met Met Ala 
    210                 215                 220                 


Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Ser Thr Pro Ser Gly His 
225                 230                 235                 240 


Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu Ser Met 
                245                 250                 255     


Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala Leu Thr 
            260                 265                 270         


Asn Ile Leu Asp Ala Gln Leu Ile Ser Gln Trp Lys Gly Asn Met Thr 
        275                 280                 285             


Arg Gln Leu Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu 
    290                 295                 300                 


Val Asn Leu Arg Arg Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe 
305                 310                 315                 320 


Arg Pro Asn Leu Ala Asp Phe Ser Ser Leu Ser Asn Gln Glu Val Leu 
                325                 330                 335     


Tyr Val Ser Arg Ala Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser 
            340                 345                 350         


Gly Thr Val Ala Ser Ser Ser Thr Ala Ile Ile Val Ser Ala Arg Met 
        355                 360                 365             


Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg 
    370                 375                 380                 


His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
385                 390                 395                 400 


<210>  237
<211>  402
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<223>  Cynomolgus PAI-1 amino acid sequence

<400>  237

Met Gln Met Ser Pro Ala Leu Ala Cys Leu Val Leu Gly Leu Ala Phe 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Thr Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Arg Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Leu Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Ala Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asp Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly His Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asn Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Gln Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asn Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  238
<211>  379
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<223>  Cynomolgus PAI-1 amino acid sequence

<400>  238

Val His His Pro Pro Ser Tyr Val Ala His Leu Ala Ser Asp Phe Gly 
1               5                   10                  15      


Val Arg Val Phe Gln Gln Val Ala Gln Ala Ser Lys Asp Arg Asn Val 
            20                  25                  30          


Val Phe Ser Pro Tyr Gly Val Ala Ser Val Leu Ala Met Leu Gln Leu 
        35                  40                  45              


Thr Thr Gly Gly Glu Thr Arg Gln Gln Ile Gln Ala Ala Met Gly Phe 
    50                  55                  60                  


Lys Ile Asp Asp Lys Gly Met Ala Pro Ala Leu Arg His Leu Tyr Lys 
65                  70                  75                  80  


Glu Leu Leu Gly Pro Trp Asn Lys Asp Glu Ile Ser Thr Thr Asp Ala 
                85                  90                  95      


Ile Phe Val Gln Arg Asp Leu Lys Leu Val Gln Gly Phe Met Pro His 
            100                 105                 110         


Phe Phe Arg Leu Phe Arg Ser Thr Val Lys Gln Val Asp Phe Ser Glu 
        115                 120                 125             


Ala Glu Arg Ala Arg Phe Ile Ile Asn Asp Trp Val Lys Thr His Thr 
    130                 135                 140                 


Lys Gly Met Ile Ser Asp Leu Leu Gly Lys Gly Ala Val Asp Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Val Leu Val Asn Ala Leu Tyr Phe Asn Gly His Trp Lys 
                165                 170                 175     


Thr Pro Phe Pro Asp Ser Ser Thr His Arg Arg Leu Phe His Lys Ser 
            180                 185                 190         


Asp Gly Ser Thr Val Ser Val Pro Met Met Ala Gln Thr Asn Lys Phe 
        195                 200                 205             


Asn Tyr Thr Glu Phe Thr Thr Pro Asp Gly His Tyr Tyr Asp Ile Leu 
    210                 215                 220                 


Glu Leu Pro Tyr His Gly Asn Thr Leu Ser Met Phe Ile Ala Ala Pro 
225                 230                 235                 240 


Tyr Glu Lys Gln Val Pro Leu Ser Ala Leu Thr Asn Ile Leu Ser Ala 
                245                 250                 255     


Gln Leu Ile Ser His Trp Lys Gly Asn Met Thr Arg Leu Pro Arg Leu 
            260                 265                 270         


Leu Val Leu Pro Lys Phe Ser Leu Glu Thr Glu Val Asp Leu Arg Lys 
        275                 280                 285             


Pro Leu Glu Asn Leu Gly Met Thr Asp Met Phe Arg Gln Phe Gln Ala 
    290                 295                 300                 


Asp Phe Thr Ser Leu Ser Asn Gln Glu Pro Leu His Val Ala Gln Ala 
305                 310                 315                 320 


Leu Gln Lys Val Lys Ile Glu Val Asn Glu Ser Gly Thr Val Ala Ser 
                325                 330                 335     


Ser Ser Thr Ala Val Ile Val Ser Ala Arg Met Ala Pro Glu Glu Ile 
            340                 345                 350         


Ile Met Asp Arg Pro Phe Leu Phe Val Val Arg His Asn Pro Thr Gly 
        355                 360                 365             


Thr Val Leu Phe Met Gly Gln Val Met Glu Pro 
    370                 375                 


<210>  239
<211>  1209
<212>  DNA
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<223>  Cynomolgus PAI-1 cDNA sequence

<400>  239
atgcagatgt ctccagccct cgcctgccta gtcctgggcc tggccttcgt ctttggtgaa       60

gggtccaccg tgcaccatcc cccatcctac gtggcccacc tggcctcaga cttcggggtt      120

agggtgtttc agcaggtggc gcaggcctcc aaagaccgca acgtggtttt ctcaccctat      180

ggggtggcct cggtgttggc catgctccag ctgacaacgg gaggagaaac ccggcagcag      240

atccaagcgg ccatgggatt caagattgat gacaagggca tggctcccgc cctccggcat      300

ctgtacaagg agctcttggg gccgtggaac aaggatgaga tcagcaccac agacgcgatc      360

tttgtccagc gggatctgaa gctggtccag ggcttcatgc cccacttctt caggctgttc      420

cggagtacgg tcaagcaggt ggacttttca gaggcagaga gagccagatt catcatcaac      480

gactgggtga agacacacac aaaagggatg atcagtgact tgcttgggaa aggagccgtg      540

gaccagctga cacggctggt gctggtgaac gccctctact tcaacggcca ctggaagact      600

cccttccccg actccagcac ccaccgccgc ctcttccaca aatcagatgg cagcactgtc      660

tctgtgccca tgatggctca gaccaacaag ttcaactata ccgagttcac cacgcccgat      720

ggccattact acgacatcct ggaactgccc taccacggaa acaccctcag catgttcatt      780

gctgcccctt atgaaaagca ggtgcctctc tctgccctca ccaacattct gagtgcccag      840

ctcatcagcc actggaaagg caacatgacc aggctgcccc gcctcctggt tctgcccaag      900

ttctccctgg agactgaagt tgacctcagg aagcccctag agaacctggg aatgaccgac      960

atgttcagac aatttcaggc ggacttcacg agtctttcaa accaagagcc tctccacgtt     1020

gcgcaagcgc ttcagaaagt gaagatcgag gtgaacgaga gtggcacggt ggcctcctca     1080

tccacagctg tcatagtctc agcccggatg gcgcctgagg agatcatcat ggacagaccc     1140

ttcctctttg tggtccggca caaccccaca ggaacagtcc ttttcatggg ccaagtgatg     1200

gaaccttga                                                             1209


<210>  240
<211>  747
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PICK167_A01 Sequence

<400>  240
ccggccatgg cccaggtaca gctgcagcag tcaggggctg aagtgaagaa gcctggctct       60

tcggtgaagg tctcctgcaa ggcttctgga ggcaccttca gcagctacgc tatcagctgg      120

gtgcgacagg cccctggaca aaggcttgag tggatgggag ggatcatccc tacttttggt      180

acagcaaact acgctcagaa gttccagggc agagtcacga ttaccgcgga cgaatccacg      240

agcacagcct acatggagct gagcggcctg aggtctgagg acacggccgt ctattactgt      300

gcgagagaga ggaggcagtg gctggaagga cactttgact actggggccg gggcaccccg      360

gtcaccgtct cgagtggtgg aggcggctct ggcggaggtg gcagcggcgg tggcggatcg      420

gacatccaga tgacccagtc cccatccttc ctgtctgcat ctattggaga cagagtcacc      480

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      540

gggaaagccc caaaactcct gatctataag gcctctagtt tagccagtgg ggccccatca      600

aggttcagcg gcagtagatc tgggacagat ttcactctca ccatcagcag cctgcagcct      660

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccacttac tttcggcgga      720

gggaccaagc tggagatcaa acgtgcg                                          747


<210>  241
<211>  747
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PICK167_A01 Sequence

<400>  241
cgcacgtttg atctccagct tggtccctcc gccgaaagta agtggataat tactatattg       60

ttggcagtaa taagtcgcaa aatcatcagg ctgcaggctg ctgatggtga gagtgaaatc      120

tgtcccagat ctactgccgc tgaaccttga tggggcccca ctggctaaac tagaggcctt      180

atagatcagg agttttgggg ctttccctgg cttctgctga taccaggcca agttgtgata      240

aataccctca ctggcccggc aggtgatggt gactctgtct ccaatagatg cagacaggaa      300

ggatggggac tgggtcatct ggatgtccga tccgccaccg ccgctgccac ctccgccaga      360

gccgcctcca ccactcgaga cggtgaccgg ggtgccccgg ccccagtagt caaagtgtcc      420

ttccagccac tgcctcctct ctctcgcaca gtaatagacg gccgtgtcct cagacctcag      480

gccgctcagc tccatgtagg ctgtgctcgt ggattcgtcc gcggtaatcg tgactctgcc      540

ctggaacttc tgagcgtagt ttgctgtacc aaaagtaggg atgatccctc ccatccactc      600

aagcctttgt ccaggggcct gtcgcaccca gctgatagcg tagctgctga aggtgcctcc      660

agaagccttg caggagacct tcaccgaaga gccaggcttc ttcacttcag cccctgactg      720

ctgcagctgt acctgggcca tggccgg                                          747


<210>  242
<211>  248
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PICK167_A01 Sequence

<400>  242

Pro Ala Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Arg Arg Gln Trp Leu Glu Gly His Phe Asp 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser 
            180                 185                 190         


Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Ala 
                245             


<210>  243
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - PICK167_A01-fgl VH

<400>  243
caggtacagc tggtgcagtc aggggctgag gtgaagaagc ctggctcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta cttttggtac agcaaactac      180

gctcagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag gtctgaggac acggccgtct attactgtgc gagagagagg      300

aggcagtggc tggaaggaca ctttgactac tggggccggg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  244
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - PICK167_A01-fgl VH

<400>  244
tgaggagacg gtgaccaggg tgccccggcc ccagtagtca aagtgtcctt ccagccactg       60

cctcctctct ctcgcacagt aatagacggc cgtgtcctca gacctcaggc tgctcagctc      120

catgtaggct gtgctcgtgg attcgtccgc ggtaatcgtg actctgccct ggaacttctg      180

agcgtagttt gctgtaccaa aagtagggat gatccctccc atccactcaa gcccttgtcc      240

aggggcctgt cgcacccagc tgatagcgta gctgctgaag gtgcctccag aagccttgca      300

ggagaccttc accgaagagc caggcttctt cacctcagcc cctgactgca ccagctgtac      360

ctg                                                                    363


<210>  245
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - PICK167_A01-fgl VH

<400>  245

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Arg Gln Trp Leu Glu Gly His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  246
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - PICK167_A01-fgl VL

<400>  246
gacatccaga tgacccagtc cccatccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacctgcc gggccagtga gggtatttat cacaacttgg cctggtatca gcagaagcca      120

gggaaagccc caaaactcct gatctataag gcctctagtt tagccagtgg ggtcccatca      180

aggttcagcg gcagtagatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacaa tatagtaatt atccacttac tttcggcgga      300

gggaccaagg tggagatcaa acgt                                             324


<210>  247
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - PICK167_A01-fgl VL

<400>  247
acgtttgatc tccaccttgg tccctccgcc gaaagtaagt ggataattac tatattgttg       60

gcagtaataa gtcgcaaaat catcaggctg caggctgctg atggtgagag tgaactctgt      120

cccagatcta ctgccgctga accttgatgg gaccccactg gctaaactag aggccttata      180

gatcaggagt tttggggctt tccctggctt ctgctgatac caggccaagt tgtgataaat      240

accctcactg gcccggcagg tgatggtgac tctgtctcca acagatgcag acagggtgga      300

tggggactgg gtcatctgga tgtc                                             324


<210>  248
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - PICK167_A01-fgl VL

<400>  248

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  249
<211>  1209
<212>  DNA
<213>  Macaca fascicularis

<220>
<221>  misc_feature
<223>  Cynomolgus PAI-1 cDNA 

<400>  249
atgcagatgt ctccagccct cgcctgccta gtcctgggcc tggccttcgt ctttggtgaa       60

gggtccaccg tgcaccatcc cccatcctac gtggcccacc tggcctcaga cttcggggtt      120

agggtgtttc agcaggtggc gcaggcctcc aaagaccgca acgtggtttt ctcaccctat      180

ggggtggcct cggtgttggc catgctccag ctgacaacgg gaggagaaac ccggcagcag      240

atccaagcgg ccatgggatt caagattgat gacaagggca tggctcccgc cctccggcat      300

ctgtacaagg agctcttggg gccgtggaac aaggatgaga tcagcaccac agacgcgatc      360

tttgtccagc gggatctgaa gctggtccag ggcttcatgc cccacttctt caggctgttc      420

cggagtacgg tcaagcaggt ggacttttca gaggcagaga gagccagatt catcatcaac      480

gactgggtga agacacacac aaaagggatg atcagtgact tgcttgggaa aggagccgtg      540

gaccagctga cacggctggt gctggtgaac gccctctact tcaacggcca ctggaagact      600

cccttccccg actccagcac ccaccgccgc ctcttccaca aatcagatgg cagcactgtc      660

tctgtgccca tgatggctca gaccaacaag ttcaactata ccgagttcac cacgcccgat      720

ggccattact acgacatcct ggaactgccc taccacggaa acaccctcag catgttcatt      780

gctgcccctt atgaaaagca ggtgcctctc tctgccctca ccaacattct gagtgcccag      840

ctcatcagcc actggaaagg caacatgacc aggctgcccc gcctcctggt tctgcccaag      900

ttctccctgg agactgaagt tgacctcagg aagcccctag agaacctggg aatgaccgac      960

atgttcagac aatttcaggc ggacttcacg agtctttcaa accaagagcc tctccacgtt     1020

gcgcaagcgc ttcagaaagt gaagatcgag gtgaacgaga gtggcacggt ggcctcctca     1080

tccacagctg tcatagtctc agcccggatg gcgcctgagg agatcatcat ggacagaccc     1140

ttcctctttg tggtccggca caaccccaca ggaacagtcc ttttcatggg ccaagtgatg     1200

gaaccttga                                                             1209

 

