
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,DIAGNOSTIC,
  AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF VALYL-TRNA SYNTHETASE
  

<130> 120161.492PC

<140> PCT                 
<141> 2011-04-29  

<150> US 61/330,783       
<151> 2010-05-03  

<150> US 61/329,470       
<151> 2010-04-29  

<160> 230

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 637
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg
625                 630                 635         


<210> 13
<211> 1911
<212> DNA
<213> Homo sapiens

<400> 13
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag g          1911

<210> 14
<211> 230
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr
225                 230 


<210> 15
<211> 690
<212> DNA
<213> Homo sapiens

<400> 15
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca                                  690

<210> 16
<211> 15
<212> PRT
<213> Mus musculus

<400> 16
Gly Pro Gly Gln Asp Pro Gln Ala Ala Leu Gly Ala Leu Gly Lys
 1               5                  10                  15  


<210> 17
<211> 77
<212> PRT
<213> Mus musculus

<400> 17
Ala Leu Asn Pro Leu Glu Asp Trp Leu Arg Leu His Thr Tyr Leu Ala
 1               5                  10                  15      
Gly Asp Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu
            20                  25                  30          
Leu Pro Phe Arg Tyr Val Leu Asp Pro Ser Ala Arg Arg Ile Trp Gly
        35                  40                  45              
Asn Val Thr Arg Trp Phe Asn Thr Cys Val Arg Gln Pro Glu Phe Arg
    50                  55                  60                  
Ala Val Leu Gly Glu Val Ala Leu Tyr Ser Gly Ala Arg
65                  70                  75          


<210> 18
<211> 15
<212> PRT
<213> Mus musculus

<400> 18
Ser Val Thr Gln Gln Pro Gly Ser Glu Val Ile Ala Pro Gln Lys
 1               5                  10                  15  


<210> 19
<211> 220
<212> PRT
<213> Mus musculus

<400> 19
Thr Pro Ala Gln Leu Lys Lys Glu Ala Lys Lys Arg Glu Lys Leu Glu
 1               5                  10                  15      
Lys Phe Gln Gln Lys Gln Lys Thr Gln Gln Gln Pro Pro His Gly Glu
            20                  25                  30          
Lys Lys Pro Lys Pro Glu Lys Lys Glu Lys Arg Asp Pro Gly Val Ile
        35                  40                  45              
Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu Lys Lys Asp Val Ser Gly
    50                  55                  60                  
Ala Met Pro Asp Ser Tyr Ser Pro Gln Tyr Val Glu Ala Ala Trp Tyr
65                  70                  75                  80  
Pro Trp Trp Glu Arg Gln Gly Phe Phe Lys Pro Glu Tyr Gly Arg Pro
                85                  90                  95      
Ser Val Ser Ala Pro Asn Pro Arg Gly Val Phe Met Met Cys Ile Pro
            100                 105                 110         
Pro Pro Asn Val Thr Gly Ser Leu His Leu Gly His Ala Leu Thr Asn
        115                 120                 125             
Ala Ile Gln Asp Ser Leu Thr Arg Trp His Arg Met Arg Gly Glu Thr
    130                 135                 140                 
Thr Leu Trp Asn Pro Gly Cys Asp His Ala Gly Ile Ala Thr Gln Val
145                 150                 155                 160 
Val Val Glu Lys Lys Leu Trp Lys Glu Arg Gly Leu Asn Arg His Gln
                165                 170                 175     
Leu Gly Arg Glu Ala Phe Leu Glu Glu Val Trp Lys Trp Lys Ala Glu
            180                 185                 190         
Lys Gly Asp Arg Ile Tyr His Gln Leu Lys Lys Leu Gly Ser Ser Leu
        195                 200                 205             
Asp Trp Asp Arg Ala Cys Phe Thr Met Asp Pro Lys
    210                 215                 220 


<210> 20
<211> 11
<212> PRT
<213> Mus musculus

<400> 20
Leu Ser Ala Thr Val Thr Glu Ala Phe Val Arg
 1               5                  10      


<210> 21
<211> 69
<212> PRT
<213> Mus musculus

<400> 21
Ile Glu Thr Met Leu Gly Asp Val Ala Val Ala Val His Pro Lys Asp
 1               5                  10                  15      
Pro Arg Tyr Gln His Leu Lys Gly Lys Cys Val Val His Pro Phe Leu
            20                  25                  30          
Ser Arg Ser Leu Pro Ile Val Phe Asp Asp Phe Val Asp Met Glu Phe
        35                  40                  45              
Gly Thr Gly Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr
    50                  55                  60                  
Glu Val Gly Gln Arg
65                  


<210> 22
<211> 21
<212> PRT
<213> Mus musculus

<400> 22
His Arg Leu Glu Ala Ile Ser Ile Met Asp Ser Lys Gly Ala Leu Ile
 1               5                  10                  15      
Asn Val Pro Pro Pro
            20      


<210> 23
<211> 504
<212> PRT
<213> Mus musculus

<400> 23
Gly Pro Gly Gln Asp Pro Gln Ala Ala Leu Gly Ala Leu Gly Lys Ala
 1               5                  10                  15      
Leu Asn Pro Leu Glu Asp Trp Leu Arg Leu His Thr Tyr Leu Ala Gly
            20                  25                  30          
Asp Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu
        35                  40                  45              
Pro Phe Arg Tyr Val Leu Asp Pro Ser Ala Arg Arg Ile Trp Gly Asn
    50                  55                  60                  
Val Thr Arg Trp Phe Asn Thr Cys Val Arg Gln Pro Glu Phe Arg Ala
65                  70                  75                  80  
Val Leu Gly Glu Val Ala Leu Tyr Ser Gly Ala Arg Ser Val Thr Gln
                85                  90                  95      
Gln Pro Gly Ser Glu Val Ile Ala Pro Gln Lys Thr Pro Ala Gln Leu
            100                 105                 110         
Lys Lys Glu Ala Lys Lys Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys
        115                 120                 125             
Gln Lys Thr Gln Gln Gln Pro Pro His Gly Glu Lys Lys Pro Lys Pro
    130                 135                 140                 
Glu Lys Lys Glu Lys Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro
145                 150                 155                 160 
Thr Pro Pro Gly Glu Lys Lys Asp Val Ser Gly Ala Met Pro Asp Ser
                165                 170                 175     
Tyr Ser Pro Gln Tyr Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Arg
            180                 185                 190         
Gln Gly Phe Phe Lys Pro Glu Tyr Gly Arg Pro Ser Val Ser Ala Pro
        195                 200                 205             
Asn Pro Arg Gly Val Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr
    210                 215                 220                 
Gly Ser Leu His Leu Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser
225                 230                 235                 240 
Leu Thr Arg Trp His Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro
                245                 250                 255     
Gly Cys Asp His Ala Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys
            260                 265                 270         
Leu Trp Lys Glu Arg Gly Leu Asn Arg His Gln Leu Gly Arg Glu Ala
        275                 280                 285             
Phe Leu Glu Glu Val Trp Lys Trp Lys Ala Glu Lys Gly Asp Arg Ile
    290                 295                 300                 
Tyr His Gln Leu Lys Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala
305                 310                 315                 320 
Cys Phe Thr Met Asp Pro Lys Leu Ser Ala Thr Val Thr Glu Ala Phe
                325                 330                 335     
Val Arg Leu His Glu Glu Gly Val Ile Tyr Arg Ser Thr Arg Leu Val
            340                 345                 350         
Asn Trp Ser Cys Thr Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp
        355                 360                 365             
Lys Lys Glu Leu Thr Gly Arg Thr Leu Leu Pro Val Pro Gly Tyr Lys
    370                 375                 380                 
Glu Lys Val Glu Phe Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln
385                 390                 395                 400 
Gly Ser Asp Ser Asp Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu
                405                 410                 415     
Thr Met Leu Gly Asp Val Ala Val Ala Val His Pro Lys Asp Pro Arg
            420                 425                 430         
Tyr Gln His Leu Lys Gly Lys Cys Val Val His Pro Phe Leu Ser Arg
        435                 440                 445             
Ser Leu Pro Ile Val Phe Asp Asp Phe Val Asp Met Glu Phe Gly Thr
    450                 455                 460                 
Gly Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val
465                 470                 475                 480 
Gly Gln Arg His Arg Leu Glu Ala Ile Ser Ile Met Asp Ser Lys Gly
                485                 490                 495     
Ala Leu Ile Asn Val Pro Pro Pro
            500                 


<210> 24
<211> 16
<212> PRT
<213> Mus musculus

<400> 24
Tyr Gly Glu Ala Gly Asp Gly Pro Gly Trp Gly Gly Pro His Pro Arg
 1               5                  10                  15      


<210> 25
<211> 83
<212> PRT
<213> Mus musculus

<400> 25
Ile Cys Leu Gln Pro Pro Pro Ser Ser Arg Thr Pro Phe Pro Pro Pro
 1               5                  10                  15      
Arg Leu Pro Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly
            20                  25                  30          
Ala Pro Ala Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro
        35                  40                  45              
Gly Gly Ser Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala
    50                  55                  60                  
Asp Thr Glu Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu
65                  70                  75                  80  
Gly Leu Arg
            


<210> 26
<211> 15
<212> PRT
<213> Mus musculus

<400> 26
Gly Pro Gly Gln Asp Pro Gln Ala Ala Leu Gly Ala Leu Gly Lys
 1               5                  10                  15  


<210> 27
<211> 10
<212> PRT
<213> Mus musculus

<400> 27
Ala Leu Asn Pro Leu Glu Asp Trp Leu Arg
 1               5                  10  


<210> 28
<211> 16
<212> PRT
<213> Mus musculus

<400> 28
Leu His Thr Tyr Leu Ala Gly Asp Ala Pro Thr Leu Ala Asp Leu Ala
 1               5                  10                  15      


<210> 29
<211> 10
<212> PRT
<213> Mus musculus

<400> 29
Ala Val Thr Ala Leu Leu Leu Pro Phe Arg
 1               5                  10  


<210> 30
<211> 28
<212> PRT
<213> Mus musculus

<400> 30
Tyr Val Leu Asp Pro Ser Ala Arg Arg Ile Trp Gly Asn Val Thr Arg
 1               5                  10                  15      
Trp Phe Asn Thr Cys Val Arg Gln Pro Glu Phe Arg
            20                  25              


<210> 31
<211> 13
<212> PRT
<213> Mus musculus

<400> 31
Ala Val Leu Gly Glu Val Ala Leu Tyr Ser Gly Ala Arg
 1               5                  10              


<210> 32
<211> 15
<212> PRT
<213> Mus musculus

<400> 32
Ser Val Thr Gln Gln Pro Gly Ser Glu Val Ile Ala Pro Gln Lys
 1               5                  10                  15  


<210> 33
<211> 206
<212> PRT
<213> Mus musculus

<400> 33
Tyr Gly Glu Ala Gly Asp Gly Pro Gly Trp Gly Gly Pro His Pro Arg
 1               5                  10                  15      
Ile Cys Leu Gln Pro Pro Pro Ser Ser Arg Thr Pro Phe Pro Pro Pro
            20                  25                  30          
Arg Leu Pro Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly
        35                  40                  45              
Ala Pro Ala Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro
    50                  55                  60                  
Gly Gly Ser Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala
65                  70                  75                  80  
Asp Thr Glu Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu
                85                  90                  95      
Gly Leu Arg Gly Pro Gly Gln Asp Pro Gln Ala Ala Leu Gly Ala Leu
            100                 105                 110         
Gly Lys Ala Leu Asn Pro Leu Glu Asp Trp Leu Arg Leu His Thr Tyr
        115                 120                 125             
Leu Ala Gly Asp Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala
    130                 135                 140                 
Leu Leu Leu Pro Phe Arg Tyr Val Leu Asp Pro Ser Ala Arg Arg Ile
145                 150                 155                 160 
Trp Gly Asn Val Thr Arg Trp Phe Asn Thr Cys Val Arg Gln Pro Glu
                165                 170                 175     
Phe Arg Ala Val Leu Gly Glu Val Ala Leu Tyr Ser Gly Ala Arg Ser
            180                 185                 190         
Val Thr Gln Gln Pro Gly Ser Glu Val Ile Ala Pro Gln Lys
        195                 200                 205     


<210> 34
<211> 150
<212> PRT
<213> Homo sapiens

<400> 34
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ile Ala Thr Arg Arg Trp Trp Trp Gln Gln Leu Gly Ser Arg Gln
    130                 135                 140                 
Cys Trp Glu Met Trp Leu
145                 150 


<210> 35
<211> 453
<212> DNA
<213> Homo sapiens

<400> 35
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccagata gcgacgagga ggtggtggtg gcaacaactc 420
ggatcgagac aatgctggga gatgtggctg tag                              453

<210> 36
<211> 245
<212> PRT
<213> Homo sapiens

<400> 36
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Pro Gln
    210                 215                 220                 
Pro Ala Ala Glu Gln Gln Pro Gly Ser Gln Arg Gly Gly Glu Gly Gln
225                 230                 235                 240 
Arg Arg Ala Glu Ser
                245 


<210> 37
<211> 738
<212> DNA
<213> Homo sapiens

<400> 37
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
gggcctccac aaccagctgc tgaacagcaa cctggatccc agcgaggtgg agaaggccaa 720
agaagggcag aaagctga                                               738

<210> 38
<211> 661
<212> PRT
<213> Homo sapiens

<400> 38
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Pro Val Glu Gly Arg Gly Arg Ala Ser Ala Ala
625                 630                 635                 640 
Ala Ala Val Val Arg Ser Leu Arg Gly Asp Gly Pro Gly Cys Gln Arg
                645                 650                 655     
Arg Cys Asp Ser Gly
            660     


<210> 39
<211> 1986
<212> DNA
<213> Homo sapiens

<400> 39
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgccg gtcgaaggac gtggtagagc ctctgctgcg 1920
gccgcagtgg tacgttcgct gcggggagat ggcccaggct gccagcgccg ctgtgactcg 1980
gggtga                                                            1986

<210> 40
<211> 625
<212> PRT
<213> Homo sapiens

<400> 40
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ser Gly Ala Phe
            580                 585                 590         
Pro Gly Ser Cys Gly Gly Ala Ile Ala Ser Gln Pro Thr Leu Ser Leu
        595                 600                 605             
Ser Val Thr Gln Arg Cys Pro Leu Gly Arg Thr Leu Met Gly Gly Thr
    610                 615                 620                 
Gly
625 


<210> 41
<211> 1878
<212> DNA
<213> Homo sapiens

<400> 41
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac agggagtggt gcatttccag gcagctgtgg tggggccatc 1800
gcatcccagc ctactttgtc actgtcagtg acccagcggt gccccctggg gaggaccctg 1860
atgggcggta ctgggtga                                               1878

<210> 42
<211> 842
<212> PRT
<213> Homo sapiens

<400> 42
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val
625                 630                 635                 640 
Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn
                645                 650                 655     
Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro
            660                 665                 670         
Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala
        675                 680                 685             
Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala
    690                 695                 700                 
His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys
705                 710                 715                 720 
Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val
                725                 730                 735     
Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg
            740                 745                 750         
Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala
        755                 760                 765             
Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Gly Leu
    770                 775                 780                 
Pro Pro Cys His Arg Ala Arg Cys Ser Arg Pro Glu Asp Glu Gln Val
785                 790                 795                 800 
Ser Arg Gln Cys His Arg Ser Pro Gly Arg His Leu Trp Asn Leu Pro
                805                 810                 815     
Ala Gly Pro Pro Gln Pro Ala Ala Glu Gln Gln Pro Gly Ser Gln Arg
            820                 825                 830         
Gly Gly Glu Gly Gln Arg Arg Ala Glu Ser
        835                 840         


<210> 43
<211> 2529
<212> DNA
<213> Homo sapiens

<400> 43
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg 1920
ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg 1980
ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt 2040
cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc 2100
ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc 2160
atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac 2220
ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag 2280
gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc 2340
cagcaaggtc tacctccatg ccatcgtgcg agatgctcac ggccggaaga tgagcaagtc 2400
tctaggcaat gtcatcgatc ccctggacgt catctatgga atctccctgc agggcctcca 2460
caaccagctg ctgaacagca acctggatcc cagcgaggtg gagaaggcca aagaagggca 2520
gaaagctga                                                         2529

<210> 44
<211> 799
<212> PRT
<213> Homo sapiens

<400> 44
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val
625                 630                 635                 640 
Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn
                645                 650                 655     
Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro
            660                 665                 670         
Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala
        675                 680                 685             
Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala
    690                 695                 700                 
His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys
705                 710                 715                 720 
Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val
                725                 730                 735     
Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg
            740                 745                 750         
Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala
        755                 760                 765             
Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Val Arg
    770                 775                 780                 
Arg Pro Glu Cys Val Leu Pro Arg Asp Thr Ala Gly Asp Arg Ser
785                 790                 795                 


<210> 45
<211> 2400
<212> DNA
<213> Homo sapiens

<400> 45
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg 1920
ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg 1980
ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt 2040
cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc 2100
ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc 2160
atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac 2220
ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag 2280
gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc 2340
cagcaagtca gaagacctga gtgtgttcta ccccgggaca ctgctggaga ccggtcatga 2400


<210> 46
<211> 550
<212> PRT
<213> Homo sapiens

<400> 46
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Gly Pro Pro
        515                 520                 525             
Gln Pro Ala Ala Glu Gln Gln Pro Gly Ser Gln Arg Gly Gly Glu Gly
    530                 535                 540                 
Gln Arg Arg Ala Glu Ser
545                 550 


<210> 47
<211> 1653
<212> DNA
<213> Homo sapiens

<400> 47
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagggcc tccacaacca gctgctgaac agcaacctgg atcccagcga 1620
ggtggagaag gccaaagaag ggcagaaagc tga                              1653

<210> 48
<211> 161
<212> PRT
<213> Homo sapiens

<400> 48
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Pro Val Glu Gly Arg Gly Arg Ala Ser Ala Ala Ala Ala Val Val
    130                 135                 140                 
Arg Ser Leu Arg Gly Asp Gly Pro Gly Cys Gln Arg Arg Cys Asp Ser
145                 150                 155                 160 
Gly
    


<210> 49
<211> 486
<212> DNA
<213> Homo sapiens

<400> 49
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccagccg gtcgaaggac gtggtagagc ctctgctgcg 420
gccgcagtgg tacgttcgct gcggggagat ggcccaggct gccagcgccg ctgtgactcg 480
gggtga                                                            486

<210> 50
<211> 559
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln Val Leu
545                 550                 555                 


<210> 51
<211> 1680
<212> DNA
<213> Homo sapiens

<400> 51
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca ggtgctgtga 1680


<210> 52
<211> 913
<212> PRT
<213> Homo sapiens

<400> 52
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val
625                 630                 635                 640 
Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn
                645                 650                 655     
Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro
            660                 665                 670         
Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala
        675                 680                 685             
Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala
    690                 695                 700                 
His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys
705                 710                 715                 720 
Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val
                725                 730                 735     
Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg
            740                 745                 750         
Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala
        755                 760                 765             
Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu
    770                 775                 780                 
Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile
785                 790                 795                 800 
Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly
                805                 810                 815     
Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val Ala Arg
            820                 825                 830         
Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu
        835                 840                 845             
Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser
    850                 855                 860                 
Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile
865                 870                 875                 880 
Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro
                885                 890                 895     
Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Val Val Thr Ser Thr Trp
            900                 905                 910         
Met
    


<210> 53
<211> 2742
<212> DNA
<213> Homo sapiens

<400> 53
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg 1920
ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg 1980
ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt 2040
cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc 2100
ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc 2160
atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac 2220
ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag 2280
gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc 2340
cagcaagatg aggatgtatt ggatacctgg ttctcctctg gcctcttccc cttatccatt 2400
ttgggctggc ccaaccagtc agaagacctg agtgtgttct accccgggac actgctggag 2460
accggtcatg acatcctctt cttctgggtg gcccggatgg tcatgctggg cctgaagctc 2520
acgggcaggc tgccctttag agaggtctac ctccatgcca tcgtgcgaga tgctcacggc 2580
cggaagatga gcaagtctct aggcaatgtc atcgatcccc tggacgtcat ctatggaatc 2640
tccctgcagg gcctccacaa ccagctgctg aacagcaacc tggatcccag cgaggtggag 2700
aaggccaaag aagggcaggt cgtgacatca acctggatgt ga                    2742

<210> 54
<211> 50
<212> DNA
<213> Homo sapiens

<400> 54
ccgaagctcg gcccaggacc cccagatagc gacgaggagg tggtggtggc            50

<210> 55
<211> 16
<212> PRT
<213> Homo sapiens

<400> 55
Arg Ser Ser Ala Gln Asp Pro Gln Ile Ala Thr Arg Arg Trp Trp Trp
 1               5                  10                  15      


<210> 56
<211> 50
<212> DNA
<213> Homo sapiens

<400> 56
gccaggcctc tctctcatca gccagggcct ccacaaccag ctgctgaaca            50

<210> 57
<211> 16
<212> PRT
<213> Homo sapiens

<400> 57
Ala Arg Pro Leu Ser His Gln Pro Gly Pro Pro Gln Pro Ala Ala Glu
 1               5                  10                  15      


<210> 58
<211> 50
<212> DNA
<213> Homo sapiens

<400> 58
catcaatgtg cctccgcctt tcctgccggt cgaaggacgt ggtagagcct            50

<210> 59
<211> 16
<212> PRT
<213> Homo sapiens

<400> 59
Ile Asn Val Pro Pro Pro Phe Leu Pro Val Glu Gly Arg Gly Arg Ala
 1               5                  10                  15      


<210> 60
<211> 50
<212> DNA
<213> Homo sapiens

<400> 60
tttgtggaca tggactttgg cacagggagt ggtgcatttc caggcagctg            50

<210> 61
<211> 16
<212> PRT
<213> Homo sapiens

<400> 61
Phe Val Asp Met Asp Phe Gly Thr Gly Ser Gly Ala Phe Pro Gly Ser
 1               5                  10                  15      


<210> 62
<211> 50
<212> DNA
<213> Homo sapiens

<400> 62
cctgacaaga tcagtctcca gcaaggtcta cctccatgcc atcgtgcgag            50

<210> 63
<211> 16
<212> PRT
<213> Homo sapiens

<400> 63
Pro Asp Lys Ile Ser Leu Gln Gln Gly Leu Pro Pro Cys His Arg Ala
 1               5                  10                  15      


<210> 64
<211> 50
<212> DNA
<213> Homo sapiens

<400> 64
cctgacaaga tcagtctcca gcaagtcaga agacctgagt gtgttctacc            50

<210> 65
<211> 16
<212> PRT
<213> Homo sapiens

<400> 65
Pro Asp Lys Ile Ser Leu Gln Gln Val Arg Arg Pro Glu Cys Val Leu
 1               5                  10                  15      


<210> 66
<211> 50
<212> DNA
<213> Homo sapiens

<400> 66
tttgcctata aggtccaagg ctcagggcct ccacaaccag ctgctgaaca            50

<210> 67
<211> 16
<212> PRT
<213> Homo sapiens

<400> 67
Phe Ala Tyr Lys Val Gln Gly Ser Gly Pro Pro Gln Pro Ala Ala Glu
 1               5                  10                  15      


<210> 68
<211> 50
<212> DNA
<213> Homo sapiens

<400> 68
ccgaagctcg gcccaggacc cccagccggt cgaaggacgt ggtagagcct            50

<210> 69
<211> 16
<212> PRT
<213> Homo sapiens

<400> 69
Arg Ser Ser Ala Gln Asp Pro Gln Pro Val Glu Gly Arg Gly Arg Ala
 1               5                  10                  15      


<210> 70
<211> 50
<212> DNA
<213> Homo sapiens

<400> 70
gcaccccaaa gataccagat accaggtgct gtgaagatca cccccgcaca            50

<210> 71
<211> 10
<212> PRT
<213> Homo sapiens

<400> 71
His Pro Lys Asp Thr Arg Tyr Gln Val Leu
 1               5                  10  


<210> 72
<211> 50
<212> DNA
<213> Homo sapiens

<400> 72
ggtggagaag gccaaagaag ggcaggtcgt gacatcaacc tggatgtgaa            50

<210> 73
<211> 15
<212> PRT
<213> Homo sapiens

<400> 73
Val Glu Lys Ala Lys Glu Gly Gln Val Val Thr Ser Thr Trp Met
 1               5                  10                  15  


<210> 74
<211> 300
<212> PRT
<213> Homo sapiens

<400> 74
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr
    290                 295                 300 


<210> 75
<211> 900
<212> DNA
<213> Homo sapiens

<400> 75
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900


<210> 76
<211> 214
<212> PRT
<213> Homo sapiens

<400> 76
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg
    210                 


<210> 77
<211> 642
<212> DNA
<213> Homo sapiens

<400> 77
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca gg                    642

<210> 78
<211> 229
<212> PRT
<213> Homo sapiens

<400> 78
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys
225                 


<210> 79
<211> 687
<212> DNA
<213> Homo sapiens

<400> 79
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaag                                     687

<210> 80
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 80
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala
            20                  25                  30          
Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly
        35                  40                  45              
Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro
    50                  55                  60                  
Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu
65                  70                  75                  80  
Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala
                85                  90                  95      
Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala
            100                 105                 110         
Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile
        115                 120                 125             
Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser
    130                 135                 140                 
Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser
145                 150                 155                 160 
Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala
                165                 170                 175     
Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe
            180                 185                 190         
Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr
        195                 200                 205             
Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu
    210                 215                 220                 
Gly Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro
225                 230                 235                 240 
Gly Pro Glu Ala Pro Ala Leu Pro Lys Thr
                245                 250 


<210> 81
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 81
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
225                 230                 235                 240 
Leu Asp Ser Thr His His His His His His
                245                 250 


<210> 82
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 82
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro
            20                  25                  30          
Asp Ala Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu
        35                  40                  45              
Ala Gly Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu
    50                  55                  60                  
Gln Pro Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro
65                  70                  75                  80  
Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala
                85                  90                  95      
Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser
            100                 105                 110         
Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu
        115                 120                 125             
Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg
    130                 135                 140                 
Ser Ser Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala
145                 150                 155                 160 
Leu Ser Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly
                165                 170                 175     
Glu Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu
            180                 185                 190         
Pro Phe Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn
        195                 200                 205             
Val Thr Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala
    210                 215                 220                 
Val Leu Gly Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His
225                 230                 235                 240 
Gln Pro Gly Pro Glu Ala Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu
                245                 250                 255     
Lys Lys Glu Ala Lys Lys Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys
            260                 265                 270         
Gln Lys Ile Gln Gln Gln Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys
        275                 280                 285             
Pro Glu Lys Arg Glu Lys Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu
    290                 295                 300                 
Pro Thr Pro Pro Gly Glu Lys Lys Asp Val Ser Gly Pro Met Pro Asp
305                 310                 315                 320 
Ser Tyr Leu Glu
                


<210> 83
<211> 324
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 83
Met Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro
 1               5                  10                  15      
Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly
            20                  25                  30          
Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro
        35                  40                  45              
Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln
    50                  55                  60                  
Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu
65                  70                  75                  80  
Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val
                85                  90                  95      
Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala
            100                 105                 110         
Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln
        115                 120                 125             
Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu
    130                 135                 140                 
Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr
145                 150                 155                 160 
Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr
                165                 170                 175     
Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp
            180                 185                 190         
Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu
        195                 200                 205             
Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro
    210                 215                 220                 
Glu Ala Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala
225                 230                 235                 240 
Lys Lys Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln
                245                 250                 255     
Gln Gln Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg
            260                 265                 270         
Glu Lys Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro
        275                 280                 285             
Gly Glu Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Leu Glu
    290                 295                 300                 
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
305                 310                 315                 320 
His His His His
                


<210> 84
<211> 170
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 84
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala
            20                  25                  30          
Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly
        35                  40                  45              
Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro
    50                  55                  60                  
Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu
65                  70                  75                  80  
Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala
                85                  90                  95      
Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala
            100                 105                 110         
Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile
        115                 120                 125             
Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser
    130                 135                 140                 
Ala Gln Asp Pro Gln Ile Ala Thr Arg Arg Trp Trp Trp Gln Gln Leu
145                 150                 155                 160 
Gly Ser Arg Gln Cys Trp Glu Met Trp Leu
                165                 170 


<210> 85
<211> 170
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 85
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ile Ala Thr Arg Arg Trp Trp Trp Gln Gln Leu Gly Ser Arg Gln
    130                 135                 140                 
Cys Trp Glu Met Trp Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
145                 150                 155                 160 
Leu Asp Ser Thr His His His His His His
                165                 170 


<210> 86
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 86
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro
            20                  25                  30          
Asp Ala Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu
        35                  40                  45              
Ala Gly Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu
    50                  55                  60                  
Gln Pro Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro
65                  70                  75                  80  
Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala
                85                  90                  95      
Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser
            100                 105                 110         
Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu
        115                 120                 125             
Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg
    130                 135                 140                 
Ser Ser Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala
145                 150                 155                 160 
Leu Ser Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly
                165                 170                 175     
Glu Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu
            180                 185                 190         
Pro Phe Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn
        195                 200                 205             
Val Thr Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala
    210                 215                 220                 
Val Leu Gly Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His
225                 230                 235                 240 
Gln Pro Gly Pro Pro Gln Pro Ala Ala Glu Gln Gln Pro Gly Ser Gln
                245                 250                 255     
Arg Gly Gly Glu Gly Gln Arg Arg Ala Glu Ser Leu Glu
            260                 265                 


<210> 87
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 87
Met Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro
 1               5                  10                  15      
Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly
            20                  25                  30          
Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro
        35                  40                  45              
Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln
    50                  55                  60                  
Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu
65                  70                  75                  80  
Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val
                85                  90                  95      
Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala
            100                 105                 110         
Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln
        115                 120                 125             
Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu
    130                 135                 140                 
Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr
145                 150                 155                 160 
Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr
                165                 170                 175     
Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp
            180                 185                 190         
Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu
        195                 200                 205             
Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro
    210                 215                 220                 
Pro Gln Pro Ala Ala Glu Gln Gln Pro Gly Ser Gln Arg Gly Gly Glu
225                 230                 235                 240 
Gly Gln Arg Arg Ala Glu Ser Leu Glu Gly Lys Pro Ile Pro Asn Pro
                245                 250                 255     
Leu Leu Gly Leu Asp Ser Thr His His His His His His
            260                 265                 


<210> 88
<211> 574
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 88
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro
            20                  25                  30          
Asp Ala Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu
        35                  40                  45              
Ala Gly Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu
    50                  55                  60                  
Gln Pro Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro
65                  70                  75                  80  
Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala
                85                  90                  95      
Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser
            100                 105                 110         
Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu
        115                 120                 125             
Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg
    130                 135                 140                 
Ser Ser Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala
145                 150                 155                 160 
Leu Ser Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly
                165                 170                 175     
Glu Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu
            180                 185                 190         
Pro Phe Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn
        195                 200                 205             
Val Thr Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala
    210                 215                 220                 
Val Leu Gly Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His
225                 230                 235                 240 
Gln Pro Gly Pro Glu Ala Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu
                245                 250                 255     
Lys Lys Glu Ala Lys Lys Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys
            260                 265                 270         
Gln Lys Ile Gln Gln Gln Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys
        275                 280                 285             
Pro Glu Lys Arg Glu Lys Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu
    290                 295                 300                 
Pro Thr Pro Pro Gly Glu Lys Lys Asp Val Ser Gly Pro Met Pro Asp
305                 310                 315                 320 
Ser Tyr Ser Pro Arg Tyr Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu
                325                 330                 335     
Gln Gln Gly Phe Phe Lys Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala
            340                 345                 350         
Ala Asn Pro Arg Gly Val Phe Met Met Cys Ile Pro Pro Pro Asn Val
        355                 360                 365             
Thr Gly Ser Leu His Leu Gly His Ala Leu Thr Asn Ala Ile Gln Asp
    370                 375                 380                 
Ser Leu Thr Arg Trp His Arg Met Arg Gly Glu Thr Thr Leu Trp Asn
385                 390                 395                 400 
Pro Gly Cys Asp His Ala Gly Ile Ala Thr Gln Val Val Val Glu Lys
                405                 410                 415     
Lys Leu Trp Arg Glu Gln Gly Leu Ser Arg His Gln Leu Gly Arg Glu
            420                 425                 430         
Ala Phe Leu Gln Glu Val Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg
        435                 440                 445             
Ile Tyr His Gln Leu Lys Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg
    450                 455                 460                 
Ala Cys Phe Thr Met Asp Pro Lys Leu Ser Ala Ala Val Thr Glu Ala
465                 470                 475                 480 
Phe Val Arg Leu His Glu Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu
                485                 490                 495     
Val Asn Trp Ser Cys Thr Leu Asn Ser Ala Ile Ser Asp Ile Glu Val
            500                 505                 510         
Asp Lys Lys Glu Leu Thr Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr
        515                 520                 525             
Lys Glu Lys Val Glu Phe Gly Val Leu Val Ser Phe Ala Tyr Lys Val
    530                 535                 540                 
Gln Gly Ser Gly Pro Pro Gln Pro Ala Ala Glu Gln Gln Pro Gly Ser
545                 550                 555                 560 
Gln Arg Gly Gly Glu Gly Gln Arg Arg Ala Glu Ser Leu Glu
                565                 570                 


<210> 89
<211> 574
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 89
Met Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro
 1               5                  10                  15      
Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly
            20                  25                  30          
Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro
        35                  40                  45              
Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln
    50                  55                  60                  
Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu
65                  70                  75                  80  
Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val
                85                  90                  95      
Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala
            100                 105                 110         
Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln
        115                 120                 125             
Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu
    130                 135                 140                 
Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr
145                 150                 155                 160 
Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr
                165                 170                 175     
Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp
            180                 185                 190         
Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu
        195                 200                 205             
Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro
    210                 215                 220                 
Glu Ala Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala
225                 230                 235                 240 
Lys Lys Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln
                245                 250                 255     
Gln Gln Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg
            260                 265                 270         
Glu Lys Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro
        275                 280                 285             
Gly Glu Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro
    290                 295                 300                 
Arg Tyr Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe
305                 310                 315                 320 
Phe Lys Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg
                325                 330                 335     
Gly Val Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu
            340                 345                 350         
His Leu Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg
        355                 360                 365             
Trp His Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp
    370                 375                 380                 
His Ala Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg
385                 390                 395                 400 
Glu Gln Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln
                405                 410                 415     
Glu Val Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln
            420                 425                 430         
Leu Lys Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr
        435                 440                 445             
Met Asp Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu
    450                 455                 460                 
His Glu Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser
465                 470                 475                 480 
Cys Thr Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu
                485                 490                 495     
Leu Thr Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val
            500                 505                 510         
Glu Phe Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Gly
        515                 520                 525             
Pro Pro Gln Pro Ala Ala Glu Gln Gln Pro Gly Ser Gln Arg Gly Gly
    530                 535                 540                 
Glu Gly Gln Arg Arg Ala Glu Ser Leu Glu Gly Lys Pro Ile Pro Asn
545                 550                 555                 560 
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                565                 570                 


<210> 90
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 90
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala
            20                  25                  30          
Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly
        35                  40                  45              
Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro
    50                  55                  60                  
Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu
65                  70                  75                  80  
Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala
                85                  90                  95      
Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala
            100                 105                 110         
Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile
        115                 120                 125             
Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser
    130                 135                 140                 
Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser
145                 150                 155                 160 
Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala
                165                 170                 175     
Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe
            180                 185                 190         
Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr
        195                 200                 205             
Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu
    210                 215                 220                 
Gly Glu Val Val Leu Tyr Ser Gly Ala Arg
225                 230                 


<210> 91
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 91
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
    210                 215                 220                 
Leu Asp Ser Thr His His His His His His
225                 230                 


<210> 92
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag (DNA2.0)

<400> 92
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala
            20                  25                  30          
Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly
        35                  40                  45              
Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro
    50                  55                  60                  
Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu
65                  70                  75                  80  
Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala
                85                  90                  95      
Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala
            100                 105                 110         
Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile
        115                 120                 125             
Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser
    130                 135                 140                 
Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser
145                 150                 155                 160 
Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala
                165                 170                 175     
Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe
            180                 185                 190         
Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr
        195                 200                 205             
Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu
    210                 215                 220                 
Gly Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro
225                 230                 235                 240 
Gly Pro Glu Ala Pro Ala Leu Pro Lys
                245                 


<210> 93
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag (DNA2.0)

<400> 93
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
225                 230                 235                 240 
Asp Ser Thr His His His His His His
                245                 


<210> 94
<211> 185
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 94
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro
            20                  25                  30          
Asp Ala Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu
        35                  40                  45              
Ala Gly Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu
    50                  55                  60                  
Gln Pro Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro
65                  70                  75                  80  
Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala
                85                  90                  95      
Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser
            100                 105                 110         
Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu
        115                 120                 125             
Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg
    130                 135                 140                 
Ser Ser Ala Gln Asp Pro Gln Pro Val Glu Gly Arg Gly Arg Ala Ser
145                 150                 155                 160 
Ala Ala Ala Ala Val Val Arg Ser Leu Arg Gly Asp Gly Pro Gly Cys
                165                 170                 175     
Gln Arg Arg Cys Asp Ser Gly Leu Glu
            180                 185 


<210> 95
<211> 185
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 95
Met Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro
 1               5                  10                  15      
Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly
            20                  25                  30          
Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro
        35                  40                  45              
Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln
    50                  55                  60                  
Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu
65                  70                  75                  80  
Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val
                85                  90                  95      
Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala
            100                 105                 110         
Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln
        115                 120                 125             
Asp Pro Gln Pro Val Glu Gly Arg Gly Arg Ala Ser Ala Ala Ala Ala
    130                 135                 140                 
Val Val Arg Ser Leu Arg Gly Asp Gly Pro Gly Cys Gln Arg Arg Cys
145                 150                 155                 160 
Asp Ser Gly Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
                165                 170                 175     
Asp Ser Thr His His His His His His
            180                 185 


<210> 96
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag (Genewiz)

<400> 96
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro
            20                  25                  30          
Asp Ala Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu
        35                  40                  45              
Ala Gly Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu
    50                  55                  60                  
Gln Pro Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro
65                  70                  75                  80  
Ala Leu Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala
                85                  90                  95      
Val Ala Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser
            100                 105                 110         
Arg Ala Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu
        115                 120                 125             
Leu Ile Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg
    130                 135                 140                 
Ser Ser Ala Gln Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala
145                 150                 155                 160 
Leu Ser Pro Leu Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly
                165                 170                 175     
Glu Ala Pro Thr Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu
            180                 185                 190         
Pro Phe Arg Tyr Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn
        195                 200                 205             
Val Thr Arg Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala
    210                 215                 220                 
Val Leu Gly Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His
225                 230                 235                 240 
Gln Pro Gly Pro Glu Ala Pro Ala Leu Pro Lys Leu Glu
                245                 250             


<210> 97
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag (GeneWiz)

<400> 97
Met Gly Ser Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro
 1               5                  10                  15      
Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly
            20                  25                  30          
Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro
        35                  40                  45              
Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln
    50                  55                  60                  
Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu
65                  70                  75                  80  
Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val
                85                  90                  95      
Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala
            100                 105                 110         
Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln
        115                 120                 125             
Asp Pro Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu
    130                 135                 140                 
Glu Glu Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr
145                 150                 155                 160 
Leu Ala Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr
                165                 170                 175     
Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp
            180                 185                 190         
Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu
        195                 200                 205             
Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro
    210                 215                 220                 
Glu Ala Pro Ala Leu Pro Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro
225                 230                 235                 240 
Leu Leu Gly Leu Asp Ser Thr His His His His His His
                245                 250             


<210> 98
<211> 699
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 98
agcaccctgt acgtaagccc gcacccagac gcattcccga gcctgcgcgc tctgattgct 60
gcgcgctacg gcgaagcggg cgaaggtccg ggttggggcg gtgcacatcc gcgcatctgt 120
ctgcagccgc ctccgacgag ccgcacgccg tttccaccgc cacgtctgcc ggccttggag 180
cagggtcctg gtggcctgtg ggtgtggggt gcgactgcgg ttgcccaact gctgtggccg 240
gcaggcctgg gtggtccggg tggcagccgt gccgcggttc tggttcagca gtgggtgagc 300
tacgccgata ccgagctgat cccggcagct tgcggtgcga ccctgccggc actgggcctg 360
cgctcttcgg cacaagaccc gcaagcggtc ctgggtgcgc tgggccgtgc gctgagcccg 420
ctggaagagt ggttgcgctt gcacacctat ctggccggtg aggcgccgac cttggccgat 480
ctggcggctg tcacggcgct gctgctgccg tttcgttatg tgctggaccc gcctgcgcgt 540
cgtatttgga acaatgtgac ccgttggttc gttacctgcg tccgtcaacc ggagttccgt 600
gccgtcctgg gcgaggttgt gttgtattcc ggtgcgcgtc cgctgagcca tcagccgggt 660
ccggaagcac cggcgttgcc gaaaacgtaa tgactcgag                        699

<210> 99
<211> 909
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 99
ggatcctcta ccctgtatgt tagccctcat cctgacgctt ttccgagtct gcgcgctctg 60
attgctgccc gttatggtga agctggtgaa ggtcctggtt ggggtggtgc tcatcctcgt 120
atttgtctgc agcctccgcc tacaagtcgt acaccgtttc cgccgccacg tctgccggca 180
ctggaacaag gcccgggtgg tctgtgggtt tggggcgcta ctgctgttgc tcaactgctg 240
tggcctgctg gtctgggagg tcctggaggt tctcgtgctg ctgtactggt tcaacaatgg 300
gtgtcttatg ccgataccga actgatccct gccgcttgtg gtgctacact gcctgctctg 360
ggtctgcgtt cttctgctca agatcctcaa gccgttctgg gtgctctggg gcgtgctctg 420
tctcctctgg aagagtggct gcgtctgcac acatatctgg caggagaagc accgacactg 480
gcagatctgg ccgctgttac agctctgctg ctgccttttc gttatgtcct ggacccacct 540
gctcgtcgta tctggaacaa tgtgacccgt tggtttgtga cctgtgttcg tcaaccggaa 600
ttccgtgctg tcctgggtga agttgtcctg tattctggtg cccgtccact gtctcatcag 660
cctggtcctg aagccccggc tctgcctaaa acagctgctc aactgaaaaa agaggcaaaa 720
aaacgtgaga aactggagaa atttcaacaa aaacagaaaa tccaacaaca acaaccgcca 780
cctggtgaaa aaaaaccgaa acctgaaaaa cgtgagaaac gtgatccggg tgttatcacc 840
tatgacctgc cgacacctcc tggcgagaaa aaagatgtga gcggtccgat gcctgattct 900
tatctcgag                                                         909

<210> 100
<211> 459
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 100
agcaccctgt acgtaagccc gcacccagac gcattcccga gcctgcgtgc gctgatcgcc 60
gctcgctacg gcgaggcggg tgaaggtccg ggctggggcg gtgcgcatcc gcgcatttgc 120
ttgcagcctc cgccgaccag ccgtaccccg tttccgccac cgcgcctgcc ggcactggag 180
cagggtccgg gtggtctgtg ggtctggggt gcgactgcgg tggcgcagct gttgtggccg 240
gcaggtttgg gcggtccagg tggctcccgt gcggcagttc tggttcaaca atgggtgtcg 300
tatgccgaca ccgagctgat ccctgcggca tgtggtgcga cgctgccggc tctgggcctg 360
cgtagcagcg cccaagatcc gcagattgcc acgcgtcgct ggtggtggca acagctgggc 420
tctcgtcagt gctgggaaat gtggctgtaa tgactcgag                        459

<210> 101
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 101
ggatccagta ctctgtatgt ctcccctcat ccggacgcct tccctagtct gcgtgcactg 60
atcgctgctc gctatggaga ggccggagaa ggtcctggtt gggggggtgc tcaccctcgt 120
atttgtctgc aaccgcctcc gacgtcccgt acacctttcc ctccgccacg cctgcctgct 180
ctggagcaag gtcctggggg actgtgggta tggggtgcca ccgccgtagc ccagctgctg 240
tggccagccg gactgggtgg acctggtgga agtcgtgccg ctgttctggt acaacaatgg 300
gtttcctatg ctgacactga gctgattcca gctgcttgtg gggcaacact gcctgccctg 360
ggactgcgct caagtgccca agatcctcag gccgtactgg gagcactggg gcgtgctctg 420
agtccactgg aagaatggct gcgcctgcac acttatctgg ccggtgaggc tcctactctg 480
gctgacctgg cagccgtaac cgccctgctg ctgcctttcc gctatgttct ggacccgcca 540
gctcgccgta tttggaataa cgtcacacgc tggttcgtaa cgtgtgtccg ccaacctgag 600
ttccgtgctg ttctgggaga ggtcgttctg tattctggcg ctcgccctct gtctcaccaa 660
cctggcccac ctcagcctgc cgctgaacaa caacctggtt ctcaacgtgg tggtgaaggc 720
caacgtcgtg ctgagagcct cgag                                        744

<210> 102
<211> 1659
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 102
ggatcctcta ccctgtatgt tagccctcat cctgacgctt ttccgagtct gcgcgctctg 60
attgctgccc gttatggtga agctggtgaa ggtcctggtt ggggtggtgc tcatcctcgt 120
atttgtctgc agcctccgcc tacaagtcgt acaccgtttc cgccgccacg tctgccggca 180
ctggaacaag gcccgggtgg tctgtgggtt tggggcgcta ctgctgttgc tcaactgctg 240
tggcctgctg gtctgggagg tcctggaggt tctcgtgctg ctgtactggt tcaacaatgg 300
gtgtcttatg ccgataccga actgatccct gccgcttgtg gtgctacact gcctgctctg 360
ggtctgcgtt cttctgctca agatcctcaa gccgttctgg gtgctctggg gcgtgctctg 420
tctcctctgg aagagtggct gcgtctgcac acatatctgg caggagaagc accgacactg 480
gcagatctgg ccgctgttac agctctgctg ctgccttttc gttatgtcct ggacccacct 540
gctcgtcgta tctggaacaa tgtgacccgt tggtttgtga cctgtgttcg tcaaccggaa 600
ttccgtgctg tcctgggtga agttgtcctg tattctggtg cccgtccact gtctcatcag 660
cctggtcctg aagccccggc tctgcctaaa acagctgctc aactgaaaaa agaggcaaaa 720
aaacgtgaga aactggagaa atttcaacaa aaacagaaaa tccaacaaca acaaccgcca 780
cctggtgaaa aaaaaccgaa acctgaaaaa cgtgagaaac gtgatccggg tgttatcacc 840
tatgacctgc cgacacctcc tggcgagaaa aaagatgtga gcggtccgat gcctgattct 900
tatagcccac gctatgtcga agccgcctgg tatccttggt gggaacaaca agggttcttt 960
aaaccggagt atggtcgtcc gaatgttagt gctgctaatc ctcgtggtgt gttcatgatg 1020
tgtatcccgc ctccaaatgt cacaggaagc ctgcacctgg ggcatgctct gactaatgcc 1080
atccaagatt cgctgacacg ctggcaccgt atgcgtggag agacaacact gtggaatccg 1140
ggatgtgacc atgccggtat tgctacccaa gttgtggtgg agaaaaaact gtggcgtgaa 1200
cagggactga gtcgtcatca actgggccgt gaagcatttc tgcaagaagt gtggaaatgg 1260
aaagaagaga aaggcgaccg tatctatcac caactgaaaa aactgggctc tagcctggat 1320
tgggaccgtg cttgcttcac aatggaccca aaactgagcg ctgctgttac cgaagccttt 1380
gttcgcctgc atgaagaggg tatcatctat cgctctaccc gtctggtaaa ctggagttgt 1440
acactgaata gtgctattag cgacatcgaa gtcgacaaaa aagagctgac aggtcgtact 1500
ctgctgtctg ttccggggta taaagagaaa gttgagttcg gcgttctggt gtctttcgcc 1560
tataaagttc agggctctgg tccacctcag cctgctgctg aacaacaacc tggttctcaa 1620
cgtggtggag agggtcaacg tcgtgctgaa agcctcgag                        1659

<210> 103
<211> 651
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 103
agcaccctgt acgtaagccc gcacccagac gcattcccga gcctgcgcgc actgattgca 60
gcgcgttacg gcgaagcggg cgaaggtccg ggctggggtg gcgcacatcc gcgcatctgc 120
ctgcagccgc ctccgacgtc ccgtaccccg tttccgccac cgcgcctgcc ggcgttggag 180
caaggtccgg gtggcctgtg ggtttggggt gccaccgctg tggcgcagct gctgtggcca 240
gcgggcttgg gtggccctgg tggtagccgt gcggcggtct tggtgcaaca gtgggtcagc 300
tatgctgaca cggaactgat tccggctgcg tgtggcgcga cgctgccggc actgggtctg 360
cgttctagcg cccaagatcc gcaggcggtc ctgggtgcct tgggtcgtgc gctgtccccg 420
ctggaagagt ggctgcgtct gcacacttat ctggcgggtg aggcgccgac cctggcggac 480
ttggcagccg tgacggccct gctgctgccg ttccgttatg tcctggatcc tccggcacgc 540
cgtatctgga acaatgttac ccgctggttc gttacctgcg ttcgtcaacc ggagtttcgt 600
gctgttctgg gcgaggtggt gctgtacagc ggtgcccgct aatgactcga g          651

<210> 104
<211> 696
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide (DNA2.0)

<400> 104
agcaccctgt acgtaagccc gcacccagac gcattcccga gcttgcgtgc tctgatcgca 60
gcccgctatg gtgaagcggg tgagggtccg ggttggggtg gcgcgcatcc gcgcatttgc 120
ttgcagccac cgccgacgag ccgtacgccg ttcccaccgc ctcgcctgcc ggcgttggaa 180
cagggccctg gcggcctgtg ggtttggggc gctaccgcgg tggcccagct gctgtggccg 240
gcaggcctgg gtggtccggg tggcagccgt gccgcggtcc tggtgcaaca atgggtttct 300
tacgcggaca cggagttgat cccggcagcg tgtggtgcga ccttgccggc actgggtctg 360
cgtagctcgg cacaggatcc gcaagcggtt ctgggtgcgc tgggccgtgc cctgagcccg 420
ctggaagagt ggctgcgcct gcacacgtat ctggccggtg aagcgccgac cctggcggac 480
ctggcggcag tgactgcgct gctgctgccg tttcgttatg tcttggatcc gcctgctcgt 540
cgcatttgga acaatgtgac ccgctggttc gtgacctgcg ttcgtcagcc ggagtttcgt 600
gcggtcctgg gtgaggttgt cctgtacagc ggcgctcgtc cgctgtccca tcaaccgggt 660
ccggaggcac cggccctgcc gaaataatga ctcgag                           696

<210> 105
<211> 492
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 105
ggatcctcta cgctgtatgt gagtcctcac cctgatgcct tccctagtct gcgtgcactg 60
atcgctgctc gttatggaga ggccggagag ggccctggct gggggggtgc tcaccctcgt 120
atttgtctgc aaccgcctcc gactagtcgt accccattcc ctccgcctcg cctgcctgct 180
ctggaacaag gccctggcgg actgtgggtc tggggtgcta cagccgtcgc ccagctgctg 240
tggccagccg gactgggagg accgggtgga agtcgtgctg ctgttctggt ccaacaatgg 300
gtttcctatg ctgacactga gctgatccca gctgcttgtg gggcaacact gcctgccctg 360
ggactgcgca gttctgctca agatcctcag cctgtggaag gtcgtggtcg tgctagtgct 420
gctgccgctg tggttcgtag cctgcgcggt gatggaccgg gatgccaacg tcgttgtgat 480
tctggtctcg ag                                                     492

<210> 106
<211> 696
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide (Genewiz)

<400> 106
ggatccagta cgctgtatgt tagccctcac cctgatgctt ttccgagtct gcgtgcactg 60
attgctgccc gttatggaga agccggtgaa ggtcctggtt ggggtggtgc tcatcctcgt 120
atttgcctgc aacctcctcc tacaagccgt acgccgttcc caccgcctcg tctgccggca 180
ctggagcaag gtcctggggg tctgtgggtt tggggcgcta ccgctgtggc tcaactgctg 240
tggcctgctg gcctgggtgg tcctggcgga agccgtgctg ctgttctggt acaacagtgg 300
gtgtcttatg ccgataccga actgattcca gctgcctgtg gtgctacact gcctgctctg 360
ggtctgcgct cttctgctca agatcctcag gctgtactgg gagcactggg acgtgctctg 420
tctcctctgg aagaatggct gcgtctgcac acatatctgg cgggagaggc accgactctg 480
gccgatctgg ctgctgtgac agctctgctg ctgccttttc gttatgtcct ggaccctcct 540
gctcgtcgta tctggaataa cgtgacccgt tggtttgtga cttgtgttcg tcaaccggag 600
tttcgtgccg ttctgggtga agttgtgctg tatagcggtg ctcgccctct gtcccatcaa 660
cctggtcctg aagcacctgc tctgcctaaa ctcgag                           696

<210> 107
<211> 390
<212> PRT
<213> Homo sapines

<400> 107
Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu
 1               5                  10                  15      
Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln
            20                  25                  30          
Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu
        35                  40                  45              
Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu
    50                  55                  60                  
Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp
65                  70                  75                  80  
Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro
                85                  90                  95      
Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp
            100                 105                 110         
Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe
        115                 120                 125             
Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp
    130                 135                 140                 
Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu
145                 150                 155                 160 
Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr
                165                 170                 175     
Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe
            180                 185                 190         
Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala
        195                 200                 205             
Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser
    210                 215                 220                 
Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile
225                 230                 235                 240 
Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile
                245                 250                 255     
Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu
            260                 265                 270         
Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val
        275                 280                 285             
Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val
    290                 295                 300                 
Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu
305                 310                 315                 320 
Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu
                325                 330                 335     
Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly
            340                 345                 350         
Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
        355                 360                 365             
Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala
    370                 375                 380                 
Leu Phe Gln Lys Met Leu
385                 390 


<210> 108
<211> 1173
<212> DNA
<213> Homo sapines

<400> 108
gacgtcatct atggaatctc cctgcagggc ctccacaacc agctgctgaa cagcaacctg 60
gatcccagcg aggtggagaa ggccaaagaa gggcagaaag ctgacttccc agcggggatt 120
cctgaatgtg gcaccgatgc tctccggttt ggattatgtg cctacatgtc ccagggtcgt 180
gacatcaacc tggatgtgaa ccggatactg ggttaccgcc acttctgcaa caagctctgg 240
aatgccacca agtttgccct tcgtggcctt gggaagggtt ttgtgccctc acccacctcc 300
cagcccggag gccatgagag cctggtggac cgctggatcc gcagccgcct gacagaggct 360
gtgaggctca gcaatcaagg cttccaggcc tacgacttcc cggccgtcac cactgcccag 420
tacagcttct ggctctatga gctctgtgat gtctacttgg agtgcctgaa acctgtactg 480
aatggggtgg accaggtggc agctgagtgt gcccgccaga ccctgtacac ttgcctggac 540
gttggcctgc ggctgctctc acccttcatg cccttcgtga cggaggagct gttccagagg 600
ctgccccgga ggatgccgca agctccccct agcctctgtg ttacccccta cccggagccc 660
tcagagtgct cctggaagga ccccgaggca gaagccgccc ttgagctggc gctaagcatc 720
acgcgagccg tgcgctccct gcgggccgac tacaacctca cccggatccg gcctgactgt 780
ttcctggaag tggcggatga ggccacgggc gccctggcat cggcggtgtc gggctacgtg 840
caggccctgg ccagcgcagg tgtggtggct gttctggccc tgggggctcc cgccccccag 900
ggttgcgctg tggctctggc ttctgatcgc tgctccatcc acctgcagct tcaggggctg 960
gtggaccctg cacgggagct gggcaagctg caagccaagc gagttgaggc ccagcggcag 1020
gcccagcgtc tgcgggaacg ccgtgctgcc tcgggctatc ctgtcaaggt gccgctcgaa 1080
gtccaggagg cagatgaagc caagctccaa cagacagaag cagagctcag gaaggtggat 1140
gaggccatcg ccctattcca gaagatgctg tga                              1173

<210> 109
<211> 369
<212> PRT
<213> Homo sapines

<400> 109
Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro
 1               5                  10                  15      
Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys
            20                  25                  30          
Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile
        35                  40                  45              
Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe
    50                  55                  60                  
Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln
65                  70                  75                  80  
Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu
                85                  90                  95      
Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe
            100                 105                 110         
Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys
        115                 120                 125             
Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln
    130                 135                 140                 
Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val
145                 150                 155                 160 
Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu
                165                 170                 175     
Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys
            180                 185                 190         
Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu
        195                 200                 205             
Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg
    210                 215                 220                 
Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe
225                 230                 235                 240 
Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser
                245                 250                 255     
Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala
            260                 265                 270         
Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp
        275                 280                 285             
Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg
    290                 295                 300                 
Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala
305                 310                 315                 320 
Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val
                325                 330                 335     
Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu
            340                 345                 350         
Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met
        355                 360                 365             
Leu
    


<210> 110
<211> 1110
<212> DNA
<213> Homo sapines

<400> 110
cccagcgagg tggagaaggc caaagaaggg cagaaagctg acttcccagc ggggattcct 60
gaatgtggca ccgatgctct ccggtttgga ttatgtgcct acatgtccca gggtcgtgac 120
atcaacctgg atgtgaaccg gatactgggt taccgccact tctgcaacaa gctctggaat 180
gccaccaagt ttgcccttcg tggccttggg aagggttttg tgccctcacc cacctcccag 240
cccggaggcc atgagagcct ggtggaccgc tggatccgca gccgcctgac agaggctgtg 300
aggctcagca atcaaggctt ccaggcctac gacttcccgg ccgtcaccac tgcccagtac 360
agcttctggc tctatgagct ctgtgatgtc tacttggagt gcctgaaacc tgtactgaat 420
ggggtggacc aggtggcagc tgagtgtgcc cgccagaccc tgtacacttg cctggacgtt 480
ggcctgcggc tgctctcacc cttcatgccc ttcgtgacgg aggagctgtt ccagaggctg 540
ccccggagga tgccgcaagc tccccctagc ctctgtgtta ccccctaccc ggagccctca 600
gagtgctcct ggaaggaccc cgaggcagaa gccgcccttg agctggcgct aagcatcacg 660
cgagccgtgc gctccctgcg ggccgactac aacctcaccc ggatccggcc tgactgtttc 720
ctggaagtgg cggatgaggc cacgggcgcc ctggcatcgg cggtgtcggg ctacgtgcag 780
gccctggcca gcgcaggtgt ggtggctgtt ctggccctgg gggctcccgc cccccagggt 840
tgcgctgtgg ctctggcttc tgatcgctgc tccatccacc tgcagcttca ggggctggtg 900
gaccctgcac gggagctggg caagctgcaa gccaagcgag ttgaggccca gcggcaggcc 960
cagcgtctgc gggaacgccg tgctgcctcg ggctatcctg tcaaggtgcc gctcgaagtc 1020
caggaggcag atgaagccaa gctccaacag acagaagcag agctcaggaa ggtggatgag 1080
gccatcgccc tattccagaa gatgctgtga                                  1110

<210> 111
<211> 693
<212> PRT
<213> Homo sapines

<400> 111
Ser Leu Pro Ile Val Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr
 1               5                  10                  15      
Gly Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val
            20                  25                  30          
Gly Gln Arg His Gly Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly
        35                  40                  45              
Ala Leu Ile Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu
    50                  55                  60                  
Ala Arg Lys Ala Val Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg
65                  70                  75                  80  
Gly Ile Glu Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys
                85                  90                  95      
Asp Val Val Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly
            100                 105                 110         
Glu Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg
        115                 120                 125             
Ile Leu Pro Glu Ala His Gln Arg Thr Trp His Ala Trp Met Asp Asn
    130                 135                 140                 
Ile Arg Glu Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile
145                 150                 155                 160 
Pro Ala Tyr Phe Val Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu
                165                 170                 175     
Asp Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala
            180                 185                 190         
Arg Glu Lys Ala Ala Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser
        195                 200                 205             
Leu Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu
    210                 215                 220                 
Phe Pro Leu Ser Ile Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser
225                 230                 235                 240 
Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe
                245                 250                 255     
Phe Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg
            260                 265                 270         
Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His
        275                 280                 285             
Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp
    290                 295                 300                 
Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn
305                 310                 315                 320 
Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys
                325                 330                 335     
Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg
            340                 345                 350         
Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp
        355                 360                 365             
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
    370                 375                 380                 
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
385                 390                 395                 400 
Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile
                405                 410                 415     
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln
            420                 425                 430         
Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu
        435                 440                 445             
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
    450                 455                 460                 
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
465                 470                 475                 480 
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
                485                 490                 495     
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro
            500                 505                 510         
Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
        515                 520                 525             
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
    530                 535                 540                 
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg
545                 550                 555                 560 
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
                565                 570                 575     
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
            580                 585                 590         
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
        595                 600                 605             
Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
    610                 615                 620                 
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala
625                 630                 635                 640 
Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr
                645                 650                 655     
Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
            660                 665                 670         
Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu
        675                 680                 685             
Phe Gln Lys Met Leu
    690             


<210> 112
<211> 2082
<212> DNA
<213> Homo sapines

<400> 112
agccttccca ttgtcttcga tgaatttgtg gacatggact ttggcacagg tgctgtgaag 60
atcacccccg cacatgacca aaatgactat gaagttgggc agcggcacgg gctggaggcc 120
atcagcatca tggactcccg gggggccctc atcaatgtgc ctccgccttt cctgggcctg 180
cccaggtttg aggccaggaa agcggtgctg gtggcgctga aggagcgggg actgttccgt 240
ggcattgagg acaaccccat ggtggtgcca ctttgcaacc ggtcgaagga cgtggtagag 300
cctctgctgc ggccgcagtg gtacgttcgc tgcggggaga tggcccaggc tgccagcgcc 360
gctgtgactc ggggtgacct ccgcatcctg cctgaggccc atcagcgcac atggcatgcc 420
tggatggaca acatccggga gtggtgcatt tccaggcagc tgtggtgggg ccatcgcatc 480
ccagcctact ttgtcactgt cagtgaccca gcggtgcccc ctggggagga ccctgatggg 540
cggtactggg tgagtggacg caatgaggcg gaggcccggg agaaggcagc caaggagttc 600
ggagtgtccc ctgacaagat cagtctccag caagatgagg atgtattgga tacctggttc 660
tcctctggcc tcttcccctt atccattttg ggctggccca accagtcaga agacctgagt 720
gtgttctacc ccgggacact gctggagacc ggtcatgaca tcctcttctt ctgggtggcc 780
cggatggtca tgctgggcct gaagctcacg ggcaggctgc cctttagaga ggtctacctc 840
catgccatcg tgcgagatgc tcacggccgg aagatgagca agtctctagg caatgtcatc 900
gatcccctgg acgtcatcta tggaatctcc ctgcagggcc tccacaacca gctgctgaac 960
agcaacctgg atcccagcga ggtggagaag gccaaagaag ggcagaaagc tgacttccca 1020
gcggggattc ctgaatgtgg caccgatgct ctccggtttg gattatgtgc ctacatgtcc 1080
cagggtcgtg acatcaacct ggatgtgaac cggatactgg gttaccgcca cttctgcaac 1140
aagctctgga atgccaccaa gtttgccctt cgtggccttg ggaagggttt tgtgccctca 1200
cccacctccc agcccggagg ccatgagagc ctggtggacc gctggatccg cagccgcctg 1260
acagaggctg tgaggctcag caatcaaggc ttccaggcct acgacttccc ggccgtcacc 1320
actgcccagt acagcttctg gctctatgag ctctgtgatg tctacttgga gtgcctgaaa 1380
cctgtactga atggggtgga ccaggtggca gctgagtgtg cccgccagac cctgtacact 1440
tgcctggacg ttggcctgcg gctgctctca cccttcatgc ccttcgtgac ggaggagctg 1500
ttccagaggc tgccccggag gatgccgcaa gctcccccta gcctctgtgt taccccctac 1560
ccggagccct cagagtgctc ctggaaggac cccgaggcag aagccgccct tgagctggcg 1620
ctaagcatca cgcgagccgt gcgctccctg cgggccgact acaacctcac ccggatccgg 1680
cctgactgtt tcctggaagt ggcggatgag gccacgggcg ccctggcatc ggcggtgtcg 1740
ggctacgtgc aggccctggc cagcgcaggt gtggtggctg ttctggccct gggggctccc 1800
gccccccagg gttgcgctgt ggctctggct tctgatcgct gctccatcca cctgcagctt 1860
caggggctgg tggaccctgc acgggagctg ggcaagctgc aagccaagcg agttgaggcc 1920
cagcggcagg cccagcgtct gcgggaacgc cgtgctgcct cgggctatcc tgtcaaggtg 1980
ccgctcgaag tccaggaggc agatgaagcc aagctccaac agacagaagc agagctcagg 2040
aaggtggatg aggccatcgc cctattccag aagatgctgt ga                    2082

<210> 113
<211> 325
<212> PRT
<213> Homo sapines

<400> 113
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
 1               5                  10                  15      
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
            20                  25                  30          
Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile
        35                  40                  45              
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln
    50                  55                  60                  
Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu
65                  70                  75                  80  
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
                85                  90                  95      
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
            100                 105                 110         
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
        115                 120                 125             
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro
    130                 135                 140                 
Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
145                 150                 155                 160 
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
                165                 170                 175     
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg
            180                 185                 190         
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
        195                 200                 205             
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
    210                 215                 220                 
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
225                 230                 235                 240 
Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
                245                 250                 255     
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala
            260                 265                 270         
Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr
        275                 280                 285             
Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
    290                 295                 300                 
Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu
305                 310                 315                 320 
Phe Gln Lys Met Leu
                325 


<210> 114
<211> 978
<212> DNA
<213> Homo sapines

<400> 114
gtgaaccgga tactgggtta ccgccacttc tgcaacaagc tctggaatgc caccaagttt 60
gcccttcgtg gccttgggaa gggttttgtg ccctcaccca cctcccagcc cggaggccat 120
gagagcctgg tggaccgctg gatccgcagc cgcctgacag aggctgtgag gctcagcaat 180
caaggcttcc aggcctacga cttcccggcc gtcaccactg cccagtacag cttctggctc 240
tatgagctct gtgatgtcta cttggagtgc ctgaaacctg tactgaatgg ggtggaccag 300
gtggcagctg agtgtgcccg ccagaccctg tacacttgcc tggacgttgg cctgcggctg 360
ctctcaccct tcatgccctt cgtgacggag gagctgttcc agaggctgcc ccggaggatg 420
ccgcaagctc cccctagcct ctgtgttacc ccctacccgg agccctcaga gtgctcctgg 480
aaggaccccg aggcagaagc cgcccttgag ctggcgctaa gcatcacgcg agccgtgcgc 540
tccctgcggg ccgactacaa cctcacccgg atccggcctg actgtttcct ggaagtggcg 600
gatgaggcca cgggcgccct ggcatcggcg gtgtcgggct acgtgcaggc cctggccagc 660
gcaggtgtgg tggctgttct ggccctgggg gctcccgccc cccagggttg cgctgtggct 720
ctggcttctg atcgctgctc catccacctg cagcttcagg ggctggtgga ccctgcacgg 780
gagctgggca agctgcaagc caagcgagtt gaggcccagc ggcaggccca gcgtctgcgg 840
gaacgccgtg ctgcctcggg ctatcctgtc aaggtgccgc tcgaagtcca ggaggcagat 900
gaagccaagc tccaacagac agaagcagag ctcaggaagg tggatgaggc catcgcccta 960
ttccagaaga tgctgtga                                               978

<210> 115
<211> 11
<212> PRT
<213> Mus musculus

<400> 115
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg
 1               5                  10      


<210> 116
<211> 232
<212> PRT
<213> Mus musculus

<400> 116
Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys
 1               5                  10                  15      
Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys
            20                  25                  30          
Gly Phe Val Pro Ser Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu
        35                  40                  45              
Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser
    50                  55                  60                  
Asn Glu Gly Phe Gln Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln
65                  70                  75                  80  
Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu
                85                  90                  95      
Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg
            100                 105                 110         
Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro
        115                 120                 125             
Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg
    130                 135                 140                 
Thr Pro Lys Ala Pro Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro
145                 150                 155                 160 
Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu
                165                 170                 175     
Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn
            180                 185                 190         
Leu Thr Arg Thr Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala
        195                 200                 205             
Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala
    210                 215                 220                 
Ser Ala Gly Val Val Ala Val Leu
225                 230         


<210> 117
<211> 18
<212> PRT
<213> Mus musculus

<400> 117
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Val Ala Ser
 1               5                  10                  15      
Asp Arg
        


<210> 118
<211> 46
<212> PRT
<213> Mus musculus

<400> 118
Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu
 1               5                  10                  15      
Leu Gly Lys Leu Gln Ala Lys Arg Ser Glu Ala Gln Arg Gln Ala Gln
            20                  25                  30          
Arg Leu Gln Glu Arg Arg Ala Ala Ser Ser Tyr Ser Ala Lys
        35                  40                  45      


<210> 119
<211> 32
<212> PRT
<213> Mus musculus

<400> 119
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
 1               5                  10                  15      
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
            20                  25                  30          


<210> 120
<211> 339
<212> PRT
<213> Mus musculus

<400> 120
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg Asp Ile Asn Leu Asp
 1               5                  10                  15      
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
            20                  25                  30          
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
        35                  40                  45              
Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu Val Asp Arg Trp Ile
    50                  55                  60                  
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Glu Gly Phe Gln
65                  70                  75                  80  
Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln Tyr Ser Phe Trp Leu
                85                  90                  95      
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
            100                 105                 110         
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
        115                 120                 125             
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
    130                 135                 140                 
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Thr Pro Lys Ala Pro
145                 150                 155                 160 
Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
                165                 170                 175     
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
            180                 185                 190         
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Thr Arg
        195                 200                 205             
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
    210                 215                 220                 
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
225                 230                 235                 240 
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
                245                 250                 255     
Val Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
            260                 265                 270         
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Ser Glu Ala
        275                 280                 285             
Gln Arg Gln Ala Gln Arg Leu Gln Glu Arg Arg Ala Ala Ser Ser Tyr
    290                 295                 300                 
Ser Ala Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
305                 310                 315                 320 
Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu
                325                 330                 335     
Phe Gln Lys
            


<210> 121
<211> 16
<212> PRT
<213> Mus musculus

<400> 121
Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg
 1               5                  10                  15      


<210> 122
<211> 328
<212> PRT
<213> Mus musculus

<400> 122
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg Asp Ile Asn Leu Asp
 1               5                  10                  15      
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
            20                  25                  30          
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
        35                  40                  45              
Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu Val Asp Arg Trp Ile
    50                  55                  60                  
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Glu Gly Phe Gln
65                  70                  75                  80  
Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln Tyr Ser Phe Trp Leu
                85                  90                  95      
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
            100                 105                 110         
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
        115                 120                 125             
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
    130                 135                 140                 
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Thr Pro Lys Ala Pro
145                 150                 155                 160 
Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
                165                 170                 175     
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
            180                 185                 190         
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Thr Arg
        195                 200                 205             
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
    210                 215                 220                 
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
225                 230                 235                 240 
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
                245                 250                 255     
Val Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
            260                 265                 270         
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Ser Glu Ala
        275                 280                 285             
Gln Arg Gln Ala Gln Arg Leu Gln Glu Arg Arg Ala Ala Ser Ser Tyr
    290                 295                 300                 
Ser Ala Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
305                 310                 315                 320 
Gln Gln Thr Glu Ala Glu Leu Arg
                325             


<210> 123
<211> 11
<212> PRT
<213> Mus musculus

<400> 123
Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
 1               5                  10      


<210> 124
<211> 355
<212> PRT
<213> Mus musculus

<400> 124
Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg
 1               5                  10                  15      
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg Asp Ile Asn Leu Asp
            20                  25                  30          
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
        35                  40                  45              
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
    50                  55                  60                  
Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu Val Asp Arg Trp Ile
65                  70                  75                  80  
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Glu Gly Phe Gln
                85                  90                  95      
Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln Tyr Ser Phe Trp Leu
            100                 105                 110         
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
        115                 120                 125             
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
    130                 135                 140                 
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
145                 150                 155                 160 
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Thr Pro Lys Ala Pro
                165                 170                 175     
Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
            180                 185                 190         
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
        195                 200                 205             
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Thr Arg
    210                 215                 220                 
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
225                 230                 235                 240 
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
                245                 250                 255     
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
            260                 265                 270         
Val Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
        275                 280                 285             
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Ser Glu Ala
    290                 295                 300                 
Gln Arg Gln Ala Gln Arg Leu Gln Glu Arg Arg Ala Ala Ser Ser Tyr
305                 310                 315                 320 
Ser Ala Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
                325                 330                 335     
Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu
            340                 345                 350         
Phe Gln Lys
        355 


<210> 125
<211> 20
<212> PRT
<213> Mus musculus

<400> 125
Ser Leu Pro Ile Val Phe Asp Asp Phe Val Asp Met Glu Phe Gly Thr
 1               5                  10                  15      
Gly Ala Val Lys
            20  


<210> 126
<211> 139
<212> PRT
<213> Mus musculus

<400> 126
Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His
 1               5                  10                  15      
Arg Leu Glu Ala Ile Ser Ile Met Asp Ser Lys Gly Ala Leu Ile Asn
            20                  25                  30          
Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala
        35                  40                  45              
Val Leu Ala Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Val Lys Asp
    50                  55                  60                  
Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu
65                  70                  75                  80  
Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln
                85                  90                  95      
Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu
            100                 105                 110         
Ala His Gln Arg Thr Trp His Ser Trp Met Asp Asn Ile Arg Asp Trp
        115                 120                 125             
Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg
    130                 135                 


<210> 127
<211> 22
<212> PRT
<213> Mus musculus

<400> 127
Ile Pro Ala Tyr Phe Ile Thr Val His Asp Pro Ala Val Pro Pro Gly
 1               5                  10                  15      
Glu Asp Pro Asp Gly Arg
            20          


<210> 128
<211> 113
<212> PRT
<213> Mus musculus

<400> 128
Tyr Trp Val Ser Gly Arg Thr Glu Ala Glu Ala Arg Glu Lys Ala Ala
 1               5                  10                  15      
Arg Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu
            20                  25                  30          
Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Phe Ser Ile
        35                  40                  45              
Phe Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly
    50                  55                  60                  
Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val Ala Arg
65                  70                  75                  80  
Met Val Met Leu Gly Leu Lys Leu Thr Gly Lys Leu Pro Phe Arg Glu
                85                  90                  95      
Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser
            100                 105                 110         
Lys
    


<210> 129
<211> 18
<212> PRT
<213> Mus musculus

<400> 129
Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile His Gly Val Ser
 1               5                  10                  15      
Leu Gln
        


<210> 130
<211> 368
<212> PRT
<213> Mus musculus

<400> 130
Gly Leu Tyr Asp Gln Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val
 1               5                  10                  15      
Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro
            20                  25                  30          
Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Thr Ser
        35                  40                  45              
Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg
    50                  55                  60                  
His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly
65                  70                  75                  80  
Leu Gly Lys Gly Phe Val Pro Ser Ala Thr Ser Lys Pro Glu Gly His
                85                  90                  95      
Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val
            100                 105                 110         
Arg Leu Ser Asn Glu Gly Phe Gln Ala Tyr Asp Phe Pro Ala Ile Thr
        115                 120                 125             
Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu
    130                 135                 140                 
Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu
145                 150                 155                 160 
Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu
                165                 170                 175     
Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu
            180                 185                 190         
Pro Arg Arg Thr Pro Lys Ala Pro Ala Ser Leu Cys Val Thr Pro Tyr
        195                 200                 205             
Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala
    210                 215                 220                 
Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala
225                 230                 235                 240 
Asp Tyr Asn Leu Thr Arg Thr Arg Pro Asp Cys Phe Leu Glu Val Ala
                245                 250                 255     
Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln
            260                 265                 270         
Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro
        275                 280                 285             
Ala Pro Gln Gly Cys Ala Val Ala Val Ala Ser Asp Arg Cys Ser Ile
    290                 295                 300                 
His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys
305                 310                 315                 320 
Leu Gln Ala Lys Arg Ser Glu Ala Gln Arg Gln Ala Gln Arg Leu Gln
                325                 330                 335     
Glu Arg Arg Ala Ala Ser Ser Tyr Ser Ala Lys Val Pro Leu Glu Val
            340                 345                 350         
Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg
        355                 360                 365             


<210> 131
<211> 11
<212> PRT
<213> Mus musculus

<400> 131
Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
 1               5                  10      


<210> 132
<211> 20
<212> PRT
<213> Mus musculus

<400> 132
Ser Leu Pro Ile Val Phe Asp Asp Phe Val Asp Met Glu Phe Gly Thr
 1               5                  10                  15      
Gly Ala Val Lys
            20  


<210> 133
<211> 15
<212> PRT
<213> Mus musculus

<400> 133
Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg
 1               5                  10                  15  


<210> 134
<211> 75
<212> PRT
<213> Mus musculus

<400> 134
His Arg Leu Glu Ala Ile Ser Ile Met Asp Ser Lys Gly Ala Leu Ile
 1               5                  10                  15      
Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys
            20                  25                  30          
Ala Val Leu Ala Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Val Lys
        35                  40                  45              
Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val
    50                  55                  60                  
Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg
65                  70                  75  


<210> 135
<211> 14
<212> PRT
<213> Mus musculus

<400> 135
Cys Gly Glu Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg
 1               5                  10                  


<210> 136
<211> 228
<212> PRT
<213> Mus musculus

<400> 136
Gly Asp Leu Arg Ile Leu Pro Glu Ala His Gln Arg Thr Trp His Ser
 1               5                  10                  15      
Trp Met Asp Asn Ile Arg Asp Trp Cys Ile Ser Arg Gln Leu Trp Trp
            20                  25                  30          
Gly His Arg Ile Pro Ala Tyr Phe Ile Thr Val His Asp Pro Ala Val
        35                  40                  45              
Pro Pro Gly Glu Asp Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Thr
    50                  55                  60                  
Glu Ala Glu Ala Arg Glu Lys Ala Ala Arg Glu Phe Gly Val Ser Pro
65                  70                  75                  80  
Asp Lys Ile Ser Leu Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe
                85                  90                  95      
Ser Ser Gly Leu Phe Pro Phe Ser Ile Phe Gly Trp Pro Asn Gln Ser
            100                 105                 110         
Glu Asp Leu Ser Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His
        115                 120                 125             
Asp Ile Leu Phe Phe Trp Val Ala Arg Met Val Met Leu Gly Leu Lys
    130                 135                 140                 
Leu Thr Gly Lys Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val
145                 150                 155                 160 
Arg Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile
                165                 170                 175     
Asp Pro Leu Asp Val Ile His Gly Val Ser Leu Gln Gly Leu Tyr Asp
            180                 185                 190         
Gln Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys
        195                 200                 205             
Glu Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr
    210                 215                 220                 
Asp Ala Leu Arg
225             


<210> 137
<211> 11
<212> PRT
<213> Mus musculus

<400> 137
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg
 1               5                  10      


<210> 138
<211> 296
<212> PRT
<213> Mus musculus

<400> 138
Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys
 1               5                  10                  15      
Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys
            20                  25                  30          
Gly Phe Val Pro Ser Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu
        35                  40                  45              
Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser
    50                  55                  60                  
Asn Glu Gly Phe Gln Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln
65                  70                  75                  80  
Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu
                85                  90                  95      
Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg
            100                 105                 110         
Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro
        115                 120                 125             
Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg
    130                 135                 140                 
Thr Pro Lys Ala Pro Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro
145                 150                 155                 160 
Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu
                165                 170                 175     
Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn
            180                 185                 190         
Leu Thr Arg Thr Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala
        195                 200                 205             
Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala
    210                 215                 220                 
Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln
225                 230                 235                 240 
Gly Cys Ala Val Ala Val Ala Ser Asp Arg Cys Ser Ile His Leu Gln
                245                 250                 255     
Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala
            260                 265                 270         
Lys Arg Ser Glu Ala Gln Arg Gln Ala Gln Arg Leu Gln Glu Arg Arg
        275                 280                 285             
Ala Ala Ser Ser Tyr Ser Ala Lys
    290                 295     


<210> 139
<211> 12
<212> PRT
<213> Mus musculus

<400> 139
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
 1               5                  10          


<210> 140
<211> 691
<212> PRT
<213> Mus musculus

<400> 140
Ser Leu Pro Ile Val Phe Asp Asp Phe Val Asp Met Glu Phe Gly Thr
 1               5                  10                  15      
Gly Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val
            20                  25                  30          
Gly Gln Arg His Arg Leu Glu Ala Ile Ser Ile Met Asp Ser Lys Gly
        35                  40                  45              
Ala Leu Ile Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu
    50                  55                  60                  
Ala Arg Lys Ala Val Leu Ala Ala Leu Lys Glu Arg Gly Leu Phe Arg
65                  70                  75                  80  
Gly Val Lys Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys
                85                  90                  95      
Asp Val Val Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly
            100                 105                 110         
Glu Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg
        115                 120                 125             
Ile Leu Pro Glu Ala His Gln Arg Thr Trp His Ser Trp Met Asp Asn
    130                 135                 140                 
Ile Arg Asp Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile
145                 150                 155                 160 
Pro Ala Tyr Phe Ile Thr Val His Asp Pro Ala Val Pro Pro Gly Glu
                165                 170                 175     
Asp Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Thr Glu Ala Glu Ala
            180                 185                 190         
Arg Glu Lys Ala Ala Arg Glu Phe Gly Val Ser Pro Asp Lys Ile Ser
        195                 200                 205             
Leu Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu
    210                 215                 220                 
Phe Pro Phe Ser Ile Phe Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser
225                 230                 235                 240 
Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe
                245                 250                 255     
Phe Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Lys
            260                 265                 270         
Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His
        275                 280                 285             
Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp
    290                 295                 300                 
Val Ile His Gly Val Ser Leu Gln Gly Leu Tyr Asp Gln Leu Leu Asn
305                 310                 315                 320 
Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys
                325                 330                 335     
Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg
            340                 345                 350         
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg Asp Ile Asn Leu Asp
        355                 360                 365             
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
    370                 375                 380                 
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
385                 390                 395                 400 
Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu Val Asp Arg Trp Ile
                405                 410                 415     
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Glu Gly Phe Gln
            420                 425                 430         
Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln Tyr Ser Phe Trp Leu
        435                 440                 445             
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
    450                 455                 460                 
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
465                 470                 475                 480 
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
                485                 490                 495     
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Thr Pro Lys Ala Pro
            500                 505                 510         
Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
        515                 520                 525             
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
    530                 535                 540                 
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Thr Arg
545                 550                 555                 560 
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
                565                 570                 575     
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
            580                 585                 590         
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
        595                 600                 605             
Val Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
    610                 615                 620                 
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Ser Glu Ala
625                 630                 635                 640 
Gln Arg Gln Ala Gln Arg Leu Gln Glu Arg Arg Ala Ala Ser Ser Tyr
                645                 650                 655     
Ser Ala Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
            660                 665                 670         
Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu
        675                 680                 685             
Phe Gln Lys
    690     


<210> 141
<211> 671
<212> PRT
<213> Mus musculus

<400> 141
Ser Leu Pro Ile Val Phe Asp Asp Phe Val Asp Met Glu Phe Gly Thr
 1               5                  10                  15      
Gly Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val
            20                  25                  30          
Gly Gln Arg His Arg Leu Glu Ala Ile Ser Ile Met Asp Ser Lys Gly
        35                  40                  45              
Ala Leu Ile Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu
    50                  55                  60                  
Ala Arg Lys Ala Val Leu Ala Ala Leu Lys Glu Arg Gly Leu Phe Arg
65                  70                  75                  80  
Gly Val Lys Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys
                85                  90                  95      
Asp Val Val Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly
            100                 105                 110         
Glu Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg
        115                 120                 125             
Ile Leu Pro Glu Ala His Gln Arg Thr Trp His Ser Trp Met Asp Asn
    130                 135                 140                 
Ile Arg Asp Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile
145                 150                 155                 160 
Pro Ala Tyr Phe Ile Thr Val His Asp Pro Ala Val Pro Pro Gly Glu
                165                 170                 175     
Asp Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Thr Glu Ala Glu Ala
            180                 185                 190         
Arg Glu Lys Ala Ala Arg Glu Phe Gly Val Ser Pro Asp Lys Ile Ser
        195                 200                 205             
Leu Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu
    210                 215                 220                 
Phe Pro Phe Ser Ile Phe Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser
225                 230                 235                 240 
Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe
                245                 250                 255     
Phe Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Lys
            260                 265                 270         
Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His
        275                 280                 285             
Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp
    290                 295                 300                 
Val Ile His Gly Val Ser Leu Gln Gly Leu Tyr Asp Gln Leu Leu Asn
305                 310                 315                 320 
Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys
                325                 330                 335     
Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg
            340                 345                 350         
Phe Gly Leu Cys Ala Tyr Thr Ser Gln Gly Arg Asp Ile Asn Leu Asp
        355                 360                 365             
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
    370                 375                 380                 
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
385                 390                 395                 400 
Ala Thr Ser Lys Pro Glu Gly His Glu Ser Leu Val Asp Arg Trp Ile
                405                 410                 415     
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Glu Gly Phe Gln
            420                 425                 430         
Ala Tyr Asp Phe Pro Ala Ile Thr Thr Ala Gln Tyr Ser Phe Trp Leu
        435                 440                 445             
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
    450                 455                 460                 
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
465                 470                 475                 480 
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
                485                 490                 495     
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Thr Pro Lys Ala Pro
            500                 505                 510         
Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
        515                 520                 525             
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
    530                 535                 540                 
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Thr Arg
545                 550                 555                 560 
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
                565                 570                 575     
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
            580                 585                 590         
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
        595                 600                 605             
Val Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
    610                 615                 620                 
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Ser Glu Ala
625                 630                 635                 640 
Gln Arg Gln Ala Gln Arg Leu Gln Glu Arg Arg Ala Ala Ser Ser Tyr
                645                 650                 655     
Ser Ala Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
            660                 665                 670     


<210> 142
<211> 11
<212> PRT
<213> Mus musculus

<400> 142
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg
 1               5                  10      


<210> 143
<211> 83
<212> PRT
<213> Mus musculus

<400> 143
Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro
 1               5                  10                  15      
Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg
            20                  25                  30          
Thr Pro Lys Ala Pro Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro
        35                  40                  45              
Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu
    50                  55                  60                  
Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn
65                  70                  75                  80  
Leu Thr Arg
            


<210> 144
<211> 26
<212> PRT
<213> Mus musculus

<400> 144
Thr Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala
 1               5                  10                  15      
Leu Ala Ser Ala Val Ser Gly Tyr Val Gln
            20                  25      


<210> 145
<211> 120
<212> PRT
<213> Mus musculus

<400> 145
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
 1               5                  10                  15      
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
            20                  25                  30          
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Thr Pro Lys Ala Pro
        35                  40                  45              
Ala Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
    50                  55                  60                  
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
65                  70                  75                  80  
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Thr Arg
                85                  90                  95      
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
            100                 105                 110         
Ser Ala Val Ser Gly Tyr Val Gln
        115                 120 


<210> 146
<211> 335
<212> PRT
<213> Homo sapiens

<400> 146
Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly
 1               5                  10                  15      
Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu
            20                  25                  30          
Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly
        35                  40                  45              
Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu
    50                  55                  60                  
Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala
65                  70                  75                  80  
Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val
                85                  90                  95      
Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala
            100                 105                 110         
Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu
        115                 120                 125             
Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln
    130                 135                 140                 
Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr
145                 150                 155                 160 
Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu
                165                 170                 175     
Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu
            180                 185                 190         
Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu
        195                 200                 205             
Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr
    210                 215                 220                 
Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly
225                 230                 235                 240 
Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys
                245                 250                 255     
Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu
            260                 265                 270         
Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg
        275                 280                 285             
Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu
    290                 295                 300                 
Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu
305                 310                 315                 320 
Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
                325                 330                 335 


<210> 147
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 147
atgtcccagg gtcgtgacat caacctggat gtgaaccgga tactgggtta ccgccacttc 60
tgcaacaagc tctggaatgc caccaagttt gcccttcgtg gccttgggaa gggttttgtg 120
ccctcaccca cctcccagcc cggaggccat gagagcctgg tggaccgctg gatccgcagc 180
cgcctgacag aggctgtgag gctcagcaat caaggcttcc aggcctacga cttcccggcc 240
gtcaccactg cccagtacag cttctggctc tatgagctct gtgatgtcta cttggagtgc 300
ctgaaacctg tactgaatgg ggtggaccag gtggcagctg agtgtgcccg ccagaccctg 360
tacacttgcc tggacgttgg cctgcggctg ctctcaccct tcatgccctt cgtgacggag 420
gagctgttcc agaggctgcc ccggaggatg ccgcaagctc cccctagcct ctgtgttacc 480
ccctacccgg agccctcaga gtgctcctgg aaggaccccg aggcagaagc cgcccttgag 540
ctggcgctaa gcatcacgcg agccgtgcgc tccctgcggg ccgactacaa cctcacccgg 600
atccggcctg actgtttcct ggaagtggcg gatgaggcca cgggcgccct ggcatcggcg 660
gtgtcgggct acgtgcaggc cctggccagc gcaggtgtgg tggctgttct ggccctgggg 720
gctcccgccc cccagggttg cgctgtggct ctggcttctg atcgctgctc catccacctg 780
cagcttcagg ggctggtgga ccctgcacgg gagctgggca agctgcaagc caagcgagtt 840
gaggcccagc ggcaggccca gcgtctgcgg gaacgccgtg ctgcctcggg ctatcctgtc 900
aaggtgccgc tcgaagtcca ggaggcagat gaagccaagc tccaacagac agaagcagag 960
ctcaggaagg tggatgaggc catcgcccta ttccagaaga tgctgtga              1008

<210> 148
<211> 620
<212> PRT
<213> Homo sapiens

<400> 148
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu
            260                 265                 270         
Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln
        275                 280                 285             
Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His
    290                 295                 300                 
Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu
305                 310                 315                 320 
Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu
                325                 330                 335     
Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg
            340                 345                 350         
Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr
        355                 360                 365             
Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu
    370                 375                 380                 
Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys
385                 390                 395                 400 
Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu
                405                 410                 415     
Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro
            420                 425                 430         
Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro
        435                 440                 445             
Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu
    450                 455                 460                 
Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp
465                 470                 475                 480 
Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp
                485                 490                 495     
Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala
            500                 505                 510         
Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala
        515                 520                 525             
Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His
    530                 535                 540                 
Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu
545                 550                 555                 560 
Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu
                565                 570                 575     
Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln
            580                 585                 590         
Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys
        595                 600                 605             
Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
    610                 615                 620 


<210> 149
<211> 1863
<212> DNA
<213> Homo sapiens

<400> 149
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaag ctgacttccc agcggggatt cctgaatgtg gcaccgatgc tctccggttt 840
ggattatgtg cctacatgtc ccagggtcgt gacatcaacc tggatgtgaa ccggatactg 900
ggttaccgcc acttctgcaa caagctctgg aatgccacca agtttgccct tcgtggcctt 960
gggaagggtt ttgtgccctc acccacctcc cagcccggag gccatgagag cctggtggac 1020
cgctggatcc gcagccgcct gacagaggct gtgaggctca gcaatcaagg cttccaggcc 1080
tacgacttcc cggccgtcac cactgcccag tacagcttct ggctctatga gctctgtgat 1140
gtctacttgg agtgcctgaa acctgtactg aatggggtgg accaggtggc agctgagtgt 1200
gcccgccaga ccctgtacac ttgcctggac gttggcctgc ggctgctctc acccttcatg 1260
cccttcgtga cggaggagct gttccagagg ctgccccgga ggatgccgca agctccccct 1320
agcctctgtg ttacccccta cccggagccc tcagagtgct cctggaagga ccccgaggca 1380
gaagccgccc ttgagctggc gctaagcatc acgcgagccg tgcgctccct gcgggccgac 1440
tacaacctca cccggatccg gcctgactgt ttcctggaag tggcggatga ggccacgggc 1500
gccctggcat cggcggtgtc gggctacgtg caggccctgg ccagcgcagg tgtggtggct 1560
gttctggccc tgggggctcc cgccccccag ggttgcgctg tggctctggc ttctgatcgc 1620
tgctccatcc acctgcagct tcaggggctg gtggaccctg cacgggagct gggcaagctg 1680
caagccaagc gagttgaggc ccagcggcag gcccagcgtc tgcgggaacg ccgtgctgcc 1740
tcgggctatc ctgtcaaggt gccgctcgaa gtccaggagg cagatgaagc caagctccaa 1800
cagacagaag cagagctcag gaaggtggat gaggccatcg ccctattcca gaagatgctg 1860
tga                                                               1863

<210> 150
<211> 418
<212> PRT
<213> Homo sapiens

<400> 150
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg
    130                 135                 140                 
Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp
145                 150                 155                 160 
Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu
                165                 170                 175     
Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp
            180                 185                 190         
Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp
        195                 200                 205             
Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu
    210                 215                 220                 
Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu
225                 230                 235                 240 
Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro
                245                 250                 255     
Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val
            260                 265                 270         
Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys
        275                 280                 285             
Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val
    290                 295                 300                 
Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu
305                 310                 315                 320 
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser
                325                 330                 335     
Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala
            340                 345                 350         
Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln
        355                 360                 365             
Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys
    370                 375                 380                 
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
385                 390                 395                 400 
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
                405                 410                 415     
Met Leu
        


<210> 151
<211> 1257
<212> DNA
<213> Homo sapiens

<400> 151
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccagccc ggaggccatg agagcctggt ggaccgctgg 420
atccgcagcc gcctgacaga ggctgtgagg ctcagcaatc aaggcttcca ggcctacgac 480
ttcccggccg tcaccactgc ccagtacagc ttctggctct atgagctctg tgatgtctac 540
ttggagtgcc tgaaacctgt actgaatggg gtggaccagg tggcagctga gtgtgcccgc 600
cagaccctgt acacttgcct ggacgttggc ctgcggctgc tctcaccctt catgcccttc 660
gtgacggagg agctgttcca gaggctgccc cggaggatgc cgcaagctcc ccctagcctc 720
tgtgttaccc cctacccgga gccctcagag tgctcctgga aggaccccga ggcagaagcc 780
gcccttgagc tggcgctaag catcacgcga gccgtgcgct ccctgcgggc cgactacaac 840
ctcacccgga tccggcctga ctgtttcctg gaagtggcgg atgaggccac gggcgccctg 900
gcatcggcgg tgtcgggcta cgtgcaggcc ctggccagcg caggtgtggt ggctgttctg 960
gccctggggg ctcccgcccc ccagggttgc gctgtggctc tggcttctga tcgctgctcc 1020
atccacctgc agcttcaggg gctggtggac cctgcacggg agctgggcaa gctgcaagcc 1080
aagcgagttg aggcccagcg gcaggcccag cgtctgcggg aacgccgtgc tgcctcgggc 1140
tatcctgtca aggtgccgct cgaagtccag gaggcagatg aagccaagct ccaacagaca 1200
gaagcagagc tcaggaaggt ggatgaggcc atcgccctat tccagaagat gctgtga    1257

<210> 152
<211> 634
<212> PRT
<213> Homo sapiens

<400> 152
Met Thr Lys Met Thr Met Lys Leu Gly Ser Gly Thr Gly Trp Arg Pro
 1               5                  10                  15      
Ser Ala Ser Trp Thr Pro Gly Gly Pro Ser Ser Met Cys Leu Arg Leu
            20                  25                  30          
Ser Cys Arg Ser Lys Asp Val Val Glu Pro Leu Leu Arg Pro Gln Trp
        35                  40                  45              
Tyr Val Arg Cys Gly Glu Met Ala Gln Ala Ala Ser Ala Ala Val Thr
    50                  55                  60                  
Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala His Gln Arg Thr Trp His
65                  70                  75                  80  
Ala Trp Met Asp Asn Ile Arg Glu Trp Cys Ile Ser Arg Gln Leu Trp
                85                  90                  95      
Trp Gly His Arg Ile Pro Ala Tyr Phe Val Thr Val Ser Asp Pro Ala
            100                 105                 110         
Val Pro Pro Gly Glu Asp Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg
        115                 120                 125             
Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala Lys Glu Phe Gly Val Ser
    130                 135                 140                 
Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu Asp Val Leu Asp Thr Trp
145                 150                 155                 160 
Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile Leu Gly Trp Pro Asn Gln
                165                 170                 175     
Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly
            180                 185                 190         
His Asp Ile Leu Phe Phe Trp Val Ala Arg Met Val Met Leu Gly Leu
        195                 200                 205             
Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile
    210                 215                 220                 
Val Arg Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val
225                 230                 235                 240 
Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His
                245                 250                 255     
Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala
            260                 265                 270         
Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly
        275                 280                 285             
Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg
    290                 295                 300                 
Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys
305                 310                 315                 320 
Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys
                325                 330                 335     
Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu
            340                 345                 350         
Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser
        355                 360                 365             
Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln
    370                 375                 380                 
Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu
385                 390                 395                 400 
Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg
                405                 410                 415     
Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro
            420                 425                 430         
Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg
        435                 440                 445             
Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro
    450                 455                 460                 
Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu
465                 470                 475                 480 
Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn
                485                 490                 495     
Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala
            500                 505                 510         
Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala
        515                 520                 525             
Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln
    530                 535                 540                 
Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln
545                 550                 555                 560 
Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala
                565                 570                 575     
Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg
            580                 585                 590         
Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala
        595                 600                 605             
Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp
    610                 615                 620                 
Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
625                 630                 


<210> 153
<211> 1905
<212> DNA
<213> Homo sapiens

<400> 153
atgaccaaaa tgactatgaa gttgggcagc ggcacgggct ggaggccatc agcatcatgg 60
actcccgggg ggccctcatc aatgtgcctc cgcctttcct gccggtcgaa ggacgtggta 120
gagcctctgc tgcggccgca gtggtacgtt cgctgcgggg agatggccca ggctgccagc 180
gccgctgtga ctcggggtga cctccgcatc ctgcctgagg cccatcagcg cacatggcat 240
gcctggatgg acaacatccg ggagtggtgc atttccaggc agctgtggtg gggccatcgc 300
atcccagcct actttgtcac tgtcagtgac ccagcggtgc cccctgggga ggaccctgat 360
gggcggtact gggtgagtgg acgcaatgag gcggaggccc gggagaaggc agccaaggag 420
ttcggagtgt cccctgacaa gatcagtctc cagcaagatg aggatgtatt ggatacctgg 480
ttctcctctg gcctcttccc cttatccatt ttgggctggc ccaaccagtc agaagacctg 540
agtgtgttct accccgggac actgctggag accggtcatg acatcctctt cttctgggtg 600
gcccggatgg tcatgctggg cctgaagctc acgggcaggc tgccctttag agaggtctac 660
ctccatgcca tcgtgcgaga tgctcacggc cggaagatga gcaagtctct aggcaatgtc 720
atcgatcccc tggacgtcat ctatggaatc tccctgcagg gcctccacaa ccagctgctg 780
aacagcaacc tggatcccag cgaggtggag aaggccaaag aagggcagaa agctgacttc 840
ccagcgggga ttcctgaatg tggcaccgat gctctccggt ttggattatg tgcctacatg 900
tcccagggtc gtgacatcaa cctggatgtg aaccggatac tgggttaccg ccacttctgc 960
aacaagctct ggaatgccac caagtttgcc cttcgtggcc ttgggaaggg ttttgtgccc 1020
tcacccacct cccagcccgg aggccatgag agcctggtgg accgctggat ccgcagccgc 1080
ctgacagagg ctgtgaggct cagcaatcaa ggcttccagg cctacgactt cccggccgtc 1140
accactgccc agtacagctt ctggctctat gagctctgtg atgtctactt ggagtgcctg 1200
aaacctgtac tgaatggggt ggaccaggtg gcagctgagt gtgcccgcca gaccctgtac 1260
acttgcctgg acgttggcct gcggctgctc tcacccttca tgcccttcgt gacggaggag 1320
ctgttccaga ggctgccccg gaggatgccg caagctcccc ctagcctctg tgttaccccc 1380
tacccggagc cctcagagtg ctcctggaag gaccccgagg cagaagccgc ccttgagctg 1440
gcgctaagca tcacgcgagc cgtgcgctcc ctgcgggccg actacaacct cacccggatc 1500
cggcctgact gtttcctgga agtggcggat gaggccacgg gcgccctggc atcggcggtg 1560
tcgggctacg tgcaggccct ggccagcgca ggtgtggtgg ctgttctggc cctgggggct 1620
cccgcccccc agggttgcgc tgtggctctg gcttctgatc gctgctccat ccacctgcag 1680
cttcaggggc tggtggaccc tgcacgggag ctgggcaagc tgcaagccaa gcgagttgag 1740
gcccagcggc aggcccagcg tctgcgggaa cgccgtgctg cctcgggcta tcctgtcaag 1800
gtgccgctcg aagtccagga ggcagatgaa gccaagctcc aacagacaga agcagagctc 1860
aggaaggtgg atgaggccat cgccctattc cagaagatgc tgtga                 1905

<210> 154
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 154
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val
625                 630                 635                 640 
Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn
                645                 650                 655     
Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro
            660                 665                 670         
Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala
        675                 680                 685             
Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala
    690                 695                 700                 
His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys
705                 710                 715                 720 
Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val
                725                 730                 735     
Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg
            740                 745                 750         
Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala
        755                 760                 765             
Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu
    770                 775                 780                 
Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile
785                 790                 795                 800 
Leu Gly Trp Pro Asn Gln Val Tyr Leu His Ala Ile Val Arg Asp Ala
                805                 810                 815     
His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu
            820                 825                 830         
Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu
        835                 840                 845             
Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln
    850                 855                 860                 
Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu
865                 870                 875                 880 
Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu
                885                 890                 895     
Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp
            900                 905                 910         
Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro
        915                 920                 925             
Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp
    930                 935                 940                 
Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe
945                 950                 955                 960 
Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp
                965                 970                 975     
Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu
            980                 985                 990         
Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr
        995                 1000                1005            
Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe
    1010                1015                1020                
Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala
1025                1030                1035               1040 
Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser
                1045                1050                1055    
Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile
            1060                1065                1070        
Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile
        1075                1080                1085            
Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu
    1090                1095                1100                
Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val
1105                1110                1115               1120 
Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val
                1125                1130                1135    
Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu
            1140                1145                1150        
Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu
        1155                1160                1165            
Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly
    1170                1175                1180                
Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
1185                1190                1195               1200 
Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala
                1205                1210                1215    
Leu Phe Gln Lys Met Leu
            1220        


<210> 155
<211> 3669
<212> DNA
<213> Homo sapiens

<400> 155
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg 1920
ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg 1980
ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt 2040
cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc 2100
ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc 2160
atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac 2220
ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag 2280
gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc 2340
cagcaagatg aggatgtatt ggatacctgg ttctcctctg gcctcttccc cttatccatt 2400
ttgggctggc ccaaccaggt ctacctccat gccatcgtgc gagatgctca cggccggaag 2460
atgagcaagt ctctaggcaa tgtcatcgat cccctggacg tcatctatgg aatctccctg 2520
cagggcctcc acaaccagct gctgaacagc aacctggatc ccagcgaggt ggagaaggcc 2580
aaagaagggc agaaagctga cttcccagcg gggattcctg aatgtggcac cgatgctctc 2640
cggtttggat tatgtgccta catgtcccag ggtcgtgaca tcaacctgga tgtgaaccgg 2700
atactgggtt accgccactt ctgcaacaag ctctggaatg ccaccaagtt tgcccttcgt 2760
ggccttggga agggttttgt gccctcaccc acctcccagc ccggaggcca tgagagcctg 2820
gtggaccgct ggatccgcag ccgcctgaca gaggctgtga ggctcagcaa tcaaggcttc 2880
caggcctacg acttcccggc cgtcaccact gcccagtaca gcttctggct ctatgagctc 2940
tgtgatgtct acttggagtg cctgaaacct gtactgaatg gggtggacca ggtggcagct 3000
gagtgtgccc gccagaccct gtacacttgc ctggacgttg gcctgcggct gctctcaccc 3060
ttcatgccct tcgtgacgga ggagctgttc cagaggctgc cccggaggat gccgcaagct 3120
ccccctagcc tctgtgttac cccctacccg gagccctcag agtgctcctg gaaggacccc 3180
gaggcagaag ccgcccttga gctggcgcta agcatcacgc gagccgtgcg ctccctgcgg 3240
gccgactaca acctcacccg gatccggcct gactgtttcc tggaagtggc ggatgaggcc 3300
acgggcgccc tggcatcggc ggtgtcgggc tacgtgcagg ccctggccag cgcaggtgtg 3360
gtggctgttc tggccctggg ggctcccgcc ccccagggtt gcgctgtggc tctggcttct 3420
gatcgctgct ccatccacct gcagcttcag gggctggtgg accctgcacg ggagctgggc 3480
aagctgcaag ccaagcgagt tgaggcccag cggcaggccc agcgtctgcg ggaacgccgt 3540
gctgcctcgg gctatcctgt caaggtgccg ctcgaagtcc aggaggcaga tgaagccaag 3600
ctccaacaga cagaagcaga gctcaggaag gtggatgagg ccatcgccct attccagaag 3660
atgctgtga                                                         3669

<210> 156
<211> 432
<212> PRT
<213> Homo sapiens

<400> 156
Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu
 1               5                  10                  15      
Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser
            20                  25                  30          
Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile
        35                  40                  45              
Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro
    50                  55                  60                  
Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala
65                  70                  75                  80  
Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala
                85                  90                  95      
Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu
            100                 105                 110         
Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala
        115                 120                 125             
Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro
    130                 135                 140                 
Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr
145                 150                 155                 160 
Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro
                165                 170                 175     
Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp
            180                 185                 190         
Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln Val
        195                 200                 205             
Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly
    210                 215                 220                 
Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu Phe
225                 230                 235                 240 
Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val
                245                 250                 255     
Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala
            260                 265                 270         
Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser
        275                 280                 285             
Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu
    290                 295                 300                 
Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly
305                 310                 315                 320 
Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu
                325                 330                 335     
Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg
            340                 345                 350         
Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu
        355                 360                 365             
Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln
    370                 375                 380                 
Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro
385                 390                 395                 400 
Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala
                405                 410                 415     
Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
            420                 425                 430         


<210> 157
<211> 1299
<212> DNA
<213> Homo sapiens

<400> 157
atggtcatgc tgggcctgaa gctcacgggc aggctgccct ttagagaggt ctacctccat 60
gccatcgtgc gagatgctca cggccggaag atgagcaagt ctctaggcaa tgtcatcgat 120
cccctggacg tcatctatgg aatctccctg cagggcctcc acaaccagct gctgaacagc 180
aacctggatc ccagcgaggt ggagaaggcc aaagaagggc agaaagctga cttcccagcg 240
gggattcctg aatgtggcac cgatgctctc cggtttggat tatgtgccta catgtcccag 300
ggtcgtgaca tcaacctgga tgtgaaccgg atactgggtt accgccactt ctgcaacaag 360
ctctggaatg ccaccaagtt tgcccttcgt ggccttggga agggttttgt gccctcaccc 420
acctcccagc ccggaggcca tgagagcctg gtggaccgct ggatccgcag ccgcctgaca 480
gaggctgtga ggctcagcaa tcaaggcttc caggcctacg acttcccggc cgtcaccact 540
gcccagtaca gcttctggct ctatgagctc tgtgatgtct acttggagtg cctgaaacct 600
gtactgaatg gggtggacca ggtggcagct gagtgtgccc gccagaccct gtacacttgc 660
ctggacgttg gcctgcggct gctctcaccc ttcatgccct tcgtgacgga ggagctgttc 720
cagaggctgc cccggaggat gccgcaagct ccccctagcc tctgtgttac cccctacccg 780
gagccctcag agtgctcctg gaaggacccc gaggcagaag ccgcccttga gctggcgcta 840
agcatcacgc gagccgtgcg ctccctgcgg gccgactaca acctcacccg gatccggcct 900
gactgtttcc tggaagtggc ggatgaggcc acgggcgccc tggcatcggc ggtgtcgggc 960
tacgtgcagg ccctggccag cgcaggtgtg gtggctgttc tggccctggg ggctcccgcc 1020
ccccagggtt gcgctgtggc tctggcttct gatcgctgct ccatccacct gcagcttcag 1080
gggctggtgg accctgcacg ggagctgggc aagctgcaag ccaagcgagt tgaggcccag 1140
cggcaggccc agcgtctgcg ggaacgccgt gctgcctcgg gctatcctgt caaggtgccg 1200
ctcgaagtcc aggaggcaga tgaagccaag ctccaacaga cagaagcaga gctcaggaag 1260
gtggatgagg ccatcgccct attccagaag atgctgtga                        1299

<210> 158
<211> 440
<212> PRT
<213> Homo sapiens

<400> 158
Met Arg Arg Arg Pro Gly Arg Arg Gln Pro Arg Ser Ser Glu Cys Pro
 1               5                  10                  15      
Leu Thr Arg Ser Val Ser Ser Lys Val Tyr Leu His Ala Ile Val Arg
            20                  25                  30          
Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp
        35                  40                  45              
Pro Leu Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln
    50                  55                  60                  
Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu
65                  70                  75                  80  
Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp
                85                  90                  95      
Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile
            100                 105                 110         
Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys
        115                 120                 125             
Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe
    130                 135                 140                 
Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp
145                 150                 155                 160 
Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln
                165                 170                 175     
Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser
            180                 185                 190         
Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro
        195                 200                 205             
Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr
    210                 215                 220                 
Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met
225                 230                 235                 240 
Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro
                245                 250                 255     
Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu
            260                 265                 270         
Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu
        275                 280                 285             
Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr
    290                 295                 300                 
Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly
305                 310                 315                 320 
Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala
                325                 330                 335     
Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys
            340                 345                 350         
Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln
        355                 360                 365             
Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg
    370                 375                 380                 
Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala
385                 390                 395                 400 
Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu
                405                 410                 415     
Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala
            420                 425                 430         
Ile Ala Leu Phe Gln Lys Met Leu
        435                 440 


<210> 159
<211> 1323
<212> DNA
<213> Homo sapiens

<400> 159
atgaggcgga ggcccgggag aaggcagcca aggagttcgg agtgtcccct gacaagatca 60
gtctccagca aggtctacct ccatgccatc gtgcgagatg ctcacggccg gaagatgagc 120
aagtctctag gcaatgtcat cgatcccctg gacgtcatct atggaatctc cctgcagggc 180
ctccacaacc agctgctgaa cagcaacctg gatcccagcg aggtggagaa ggccaaagaa 240
gggcagaaag ctgacttccc agcggggatt cctgaatgtg gcaccgatgc tctccggttt 300
ggattatgtg cctacatgtc ccagggtcgt gacatcaacc tggatgtgaa ccggatactg 360
ggttaccgcc acttctgcaa caagctctgg aatgccacca agtttgccct tcgtggcctt 420
gggaagggtt ttgtgccctc acccacctcc cagcccggag gccatgagag cctggtggac 480
cgctggatcc gcagccgcct gacagaggct gtgaggctca gcaatcaagg cttccaggcc 540
tacgacttcc cggccgtcac cactgcccag tacagcttct ggctctatga gctctgtgat 600
gtctacttgg agtgcctgaa acctgtactg aatggggtgg accaggtggc agctgagtgt 660
gcccgccaga ccctgtacac ttgcctggac gttggcctgc ggctgctctc acccttcatg 720
cccttcgtga cggaggagct gttccagagg ctgccccgga ggatgccgca agctccccct 780
agcctctgtg ttacccccta cccggagccc tcagagtgct cctggaagga ccccgaggca 840
gaagccgccc ttgagctggc gctaagcatc acgcgagccg tgcgctccct gcgggccgac 900
tacaacctca cccggatccg gcctgactgt ttcctggaag tggcggatga ggccacgggc 960
gccctggcat cggcggtgtc gggctacgtg caggccctgg ccagcgcagg tgtggtggct 1020
gttctggccc tgggggctcc cgccccccag ggttgcgctg tggctctggc ttctgatcgc 1080
tgctccatcc acctgcagct tcaggggctg gtggaccctg cacgggagct gggcaagctg 1140
caagccaagc gagttgaggc ccagcggcag gcccagcgtc tgcgggaacg ccgtgctgcc 1200
tcgggctatc ctgtcaaggt gccgctcgaa gtccaggagg cagatgaagc caagctccaa 1260
cagacagaag cagagctcag gaaggtggat gaggccatcg ccctattcca gaagatgctg 1320
tga                                                               1323

<210> 160
<211> 482
<212> PRT
<213> Homo sapiens

<400> 160
Met Arg Arg Arg Pro Gly Arg Arg Gln Pro Arg Ser Ser Glu Cys Pro
 1               5                  10                  15      
Leu Thr Arg Ser Val Ser Ser Lys Ser Glu Asp Leu Ser Val Phe Tyr
            20                  25                  30          
Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val
        35                  40                  45              
Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe
    50                  55                  60                  
Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys
65                  70                  75                  80  
Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr
                85                  90                  95      
Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu
            100                 105                 110         
Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe
        115                 120                 125             
Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu
    130                 135                 140                 
Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg
145                 150                 155                 160 
Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys
                165                 170                 175     
Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser
            180                 185                 190         
Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg
        195                 200                 205             
Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp
    210                 215                 220                 
Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu
225                 230                 235                 240 
Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp
                245                 250                 255     
Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp
            260                 265                 270         
Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu
        275                 280                 285             
Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu
    290                 295                 300                 
Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro
305                 310                 315                 320 
Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val
                325                 330                 335     
Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys
            340                 345                 350         
Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val
        355                 360                 365             
Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu
    370                 375                 380                 
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser
385                 390                 395                 400 
Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala
                405                 410                 415     
Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln
            420                 425                 430         
Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys
        435                 440                 445             
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
    450                 455                 460                 
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
465                 470                 475                 480 
Met Leu
        


<210> 161
<211> 1449
<212> DNA
<213> Homo sapiens

<400> 161
atgaggcgga ggcccgggag aaggcagcca aggagttcgg agtgtcccct gacaagatca 60
gtctccagca agtcagaaga cctgagtgtg ttctaccccg ggacactgct ggagaccggt 120
catgacatcc tcttcttctg ggtggcccgg atggtcatgc tgggcctgaa gctcacgggc 180
aggctgccct ttagagaggt ctacctccat gccatcgtgc gagatgctca cggccggaag 240
atgagcaagt ctctaggcaa tgtcatcgat cccctggacg tcatctatgg aatctccctg 300
cagggcctcc acaaccagct gctgaacagc aacctggatc ccagcgaggt ggagaaggcc 360
aaagaagggc agaaagctga cttcccagcg gggattcctg aatgtggcac cgatgctctc 420
cggtttggat tatgtgccta catgtcccag ggtcgtgaca tcaacctgga tgtgaaccgg 480
atactgggtt accgccactt ctgcaacaag ctctggaatg ccaccaagtt tgcccttcgt 540
ggccttggga agggttttgt gccctcaccc acctcccagc ccggaggcca tgagagcctg 600
gtggaccgct ggatccgcag ccgcctgaca gaggctgtga ggctcagcaa tcaaggcttc 660
caggcctacg acttcccggc cgtcaccact gcccagtaca gcttctggct ctatgagctc 720
tgtgatgtct acttggagtg cctgaaacct gtactgaatg gggtggacca ggtggcagct 780
gagtgtgccc gccagaccct gtacacttgc ctggacgttg gcctgcggct gctctcaccc 840
ttcatgccct tcgtgacgga ggagctgttc cagaggctgc cccggaggat gccgcaagct 900
ccccctagcc tctgtgttac cccctacccg gagccctcag agtgctcctg gaaggacccc 960
gaggcagaag ccgcccttga gctggcgcta agcatcacgc gagccgtgcg ctccctgcgg 1020
gccgactaca acctcacccg gatccggcct gactgtttcc tggaagtggc ggatgaggcc 1080
acgggcgccc tggcatcggc ggtgtcgggc tacgtgcagg ccctggccag cgcaggtgtg 1140
gtggctgttc tggccctggg ggctcccgcc ccccagggtt gcgctgtggc tctggcttct 1200
gatcgctgct ccatccacct gcagcttcag gggctggtgg accctgcacg ggagctgggc 1260
aagctgcaag ccaagcgagt tgaggcccag cggcaggccc agcgtctgcg ggaacgccgt 1320
gctgcctcgg gctatcctgt caaggtgccg ctcgaagtcc aggaggcaga tgaagccaag 1380
ctccaacaga cagaagcaga gctcaggaag gtggatgagg ccatcgccct attccagaag 1440
atgctgtga                                                         1449

<210> 162
<211> 724
<212> PRT
<213> Homo sapiens

<400> 162
Met Leu Gly Asp Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr
 1               5                  10                  15      
Gln His Leu Lys Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser
            20                  25                  30          
Leu Pro Ile Val Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly
        35                  40                  45              
Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly
    50                  55                  60                  
Gln Arg His Gly Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala
65                  70                  75                  80  
Leu Ile Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala
                85                  90                  95      
Arg Lys Ala Val Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly
            100                 105                 110         
Ile Glu Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp
        115                 120                 125             
Val Val Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu
    130                 135                 140                 
Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile
145                 150                 155                 160 
Leu Pro Glu Ala His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile
                165                 170                 175     
Arg Glu Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro
            180                 185                 190         
Ala Tyr Phe Val Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp
        195                 200                 205             
Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg
    210                 215                 220                 
Glu Lys Ala Ala Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu
225                 230                 235                 240 
Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe
                245                 250                 255     
Pro Leu Ser Ile Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val
            260                 265                 270         
Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe
        275                 280                 285             
Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu
    290                 295                 300                 
Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly
305                 310                 315                 320 
Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val
                325                 330                 335     
Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser
            340                 345                 350         
Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala
        355                 360                 365             
Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe
    370                 375                 380                 
Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val
385                 390                 395                 400 
Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala
                405                 410                 415     
Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro
            420                 425                 430         
Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg
        435                 440                 445             
Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala
    450                 455                 460                 
Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr
465                 470                 475                 480 
Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly
                485                 490                 495     
Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys
            500                 505                 510         
Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr
        515                 520                 525             
Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro
    530                 535                 540                 
Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys
545                 550                 555                 560 
Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg
                565                 570                 575     
Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro
            580                 585                 590         
Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser
        595                 600                 605             
Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala
    610                 615                 620                 
Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu
625                 630                 635                 640 
Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp
                645                 650                 655     
Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln
            660                 665                 670         
Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro
        675                 680                 685             
Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln
    690                 695                 700                 
Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe
705                 710                 715                 720 
Gln Lys Met Leu
                


<210> 163
<211> 2175
<212> DNA
<213> Homo sapiens

<400> 163
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 60
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 120
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 180
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 240
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg 300
ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg 360
ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt 420
cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc 480
ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc 540
atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac 600
ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag 660
gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc 720
cagcaagatg aggatgtatt ggatacctgg ttctcctctg gcctcttccc cttatccatt 780
ttgggctggc ccaaccagtc agaagacctg agtgtgttct accccgggac actgctggag 840
accggtcatg acatcctctt cttctgggtg gcccggatgg tcatgctggg cctgaagctc 900
acgggcaggc tgccctttag agaggtctac ctccatgcca tcgtgcgaga tgctcacggc 960
cggaagatga gcaagtctct aggcaatgtc atcgatcccc tggacgtcat ctatggaatc 1020
tccctgcagg gcctccacaa ccagctgctg aacagcaacc tggatcccag cgaggtggag 1080
aaggccaaag aagggcagaa agctgacttc ccagcgggga ttcctgaatg tggcaccgat 1140
gctctccggt ttggattatg tgcctacatg tcccagggtc gtgacatcaa cctggatgtg 1200
aaccggatac tgggttaccg ccacttctgc aacaagctct ggaatgccac caagtttgcc 1260
cttcgtggcc ttgggaaggg ttttgtgccc tcacccacct cccagcccgg aggccatgag 1320
agcctggtgg accgctggat ccgcagccgc ctgacagagg ctgtgaggct cagcaatcaa 1380
ggcttccagg cctacgactt cccggccgtc accactgccc agtacagctt ctggctctat 1440
gagctctgtg atgtctactt ggagtgcctg aaacctgtac tgaatggggt ggaccaggtg 1500
gcagctgagt gtgcccgcca gaccctgtac acttgcctgg acgttggcct gcggctgctc 1560
tcacccttca tgcccttcgt gacggaggag ctgttccaga ggctgccccg gaggatgccg 1620
caagctcccc ctagcctctg tgttaccccc tacccggagc cctcagagtg ctcctggaag 1680
gaccccgagg cagaagccgc ccttgagctg gcgctaagca tcacgcgagc cgtgcgctcc 1740
ctgcgggccg actacaacct cacccggatc cggcctgact gtttcctgga agtggcggat 1800
gaggccacgg gcgccctggc atcggcggtg tcgggctacg tgcaggccct ggccagcgca 1860
ggtgtggtgg ctgttctggc cctgggggct cccgcccccc agggttgcgc tgtggctctg 1920
gcttctgatc gctgctccat ccacctgcag cttcaggggc tggtggaccc tgcacgggag 1980
ctgggcaagc tgcaagccaa gcgagttgag gcccagcggc aggcccagcg tctgcgggaa 2040
cgccgtgctg cctcgggcta tcctgtcaag gtgccgctcg aagtccagga ggcagatgaa 2100
gccaagctcc aacagacaga agcagagctc aggaaggtgg atgaggccat cgccctattc 2160
cagaagatgc tgtga                                                  2175

<210> 164
<211> 836
<212> PRT
<213> Homo sapiens

<400> 164
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln His Leu Lys Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser
    130                 135                 140                 
Leu Pro Ile Val Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly
145                 150                 155                 160 
Ala Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly
                165                 170                 175     
Gln Arg His Gly Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala
            180                 185                 190         
Leu Ile Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala
        195                 200                 205             
Arg Lys Ala Val Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly
    210                 215                 220                 
Ile Glu Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp
225                 230                 235                 240 
Val Val Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu
                245                 250                 255     
Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile
            260                 265                 270         
Leu Pro Glu Ala His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile
        275                 280                 285             
Arg Glu Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro
    290                 295                 300                 
Ala Tyr Phe Val Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp
305                 310                 315                 320 
Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg
                325                 330                 335     
Glu Lys Ala Ala Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu
            340                 345                 350         
Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe
        355                 360                 365             
Pro Leu Ser Ile Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val
    370                 375                 380                 
Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe
385                 390                 395                 400 
Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu
                405                 410                 415     
Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly
            420                 425                 430         
Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val
        435                 440                 445             
Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser
    450                 455                 460                 
Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala
465                 470                 475                 480 
Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe
                485                 490                 495     
Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val
            500                 505                 510         
Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala
        515                 520                 525             
Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro
    530                 535                 540                 
Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg
545                 550                 555                 560 
Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala
                565                 570                 575     
Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr
            580                 585                 590         
Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly
        595                 600                 605             
Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys
    610                 615                 620                 
Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr
625                 630                 635                 640 
Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro
                645                 650                 655     
Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys
            660                 665                 670         
Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg
        675                 680                 685             
Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro
    690                 695                 700                 
Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser
705                 710                 715                 720 
Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala
                725                 730                 735     
Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu
            740                 745                 750         
Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp
        755                 760                 765             
Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln
    770                 775                 780                 
Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro
785                 790                 795                 800 
Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln
                805                 810                 815     
Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe
            820                 825                 830         
Gln Lys Met Leu
        835     


<210> 165
<211> 2511
<212> DNA
<213> Homo sapiens

<400> 165
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccagcac ctgaagggga agaacgtgat ccacccattc 420
ctgtctcgga gccttcccat tgtcttcgat gaatttgtgg acatggactt tggcacaggt 480
gctgtgaaga tcacccccgc acatgaccaa aatgactatg aagttgggca gcggcacggg 540
ctggaggcca tcagcatcat ggactcccgg ggggccctca tcaatgtgcc tccgcctttc 600
ctgggcctgc ccaggtttga ggccaggaaa gcggtgctgg tggcgctgaa ggagcgggga 660
ctgttccgtg gcattgagga caaccccatg gtggtgccac tttgcaaccg gtcgaaggac 720
gtggtagagc ctctgctgcg gccgcagtgg tacgttcgct gcggggagat ggcccaggct 780
gccagcgccg ctgtgactcg gggtgacctc cgcatcctgc ctgaggccca tcagcgcaca 840
tggcatgcct ggatggacaa catccgggag tggtgcattt ccaggcagct gtggtggggc 900
catcgcatcc cagcctactt tgtcactgtc agtgacccag cggtgccccc tggggaggac 960
cctgatgggc ggtactgggt gagtggacgc aatgaggcgg aggcccggga gaaggcagcc 1020
aaggagttcg gagtgtcccc tgacaagatc agtctccagc aagatgagga tgtattggat 1080
acctggttct cctctggcct cttcccctta tccattttgg gctggcccaa ccagtcagaa 1140
gacctgagtg tgttctaccc cgggacactg ctggagaccg gtcatgacat cctcttcttc 1200
tgggtggccc ggatggtcat gctgggcctg aagctcacgg gcaggctgcc ctttagagag 1260
gtctacctcc atgccatcgt gcgagatgct cacggccgga agatgagcaa gtctctaggc 1320
aatgtcatcg atcccctgga cgtcatctat ggaatctccc tgcagggcct ccacaaccag 1380
ctgctgaaca gcaacctgga tcccagcgag gtggagaagg ccaaagaagg gcagaaagct 1440
gacttcccag cggggattcc tgaatgtggc accgatgctc tccggtttgg attatgtgcc 1500
tacatgtccc agggtcgtga catcaacctg gatgtgaacc ggatactggg ttaccgccac 1560
ttctgcaaca agctctggaa tgccaccaag tttgcccttc gtggccttgg gaagggtttt 1620
gtgccctcac ccacctccca gcccggaggc catgagagcc tggtggaccg ctggatccgc 1680
agccgcctga cagaggctgt gaggctcagc aatcaaggct tccaggccta cgacttcccg 1740
gccgtcacca ctgcccagta cagcttctgg ctctatgagc tctgtgatgt ctacttggag 1800
tgcctgaaac ctgtactgaa tggggtggac caggtggcag ctgagtgtgc ccgccagacc 1860
ctgtacactt gcctggacgt tggcctgcgg ctgctctcac ccttcatgcc cttcgtgacg 1920
gaggagctgt tccagaggct gccccggagg atgccgcaag ctccccctag cctctgtgtt 1980
accccctacc cggagccctc agagtgctcc tggaaggacc ccgaggcaga agccgccctt 2040
gagctggcgc taagcatcac gcgagccgtg cgctccctgc gggccgacta caacctcacc 2100
cggatccggc ctgactgttt cctggaagtg gcggatgagg ccacgggcgc cctggcatcg 2160
gcggtgtcgg gctacgtgca ggccctggcc agcgcaggtg tggtggctgt tctggccctg 2220
ggggctcccg ccccccaggg ttgcgctgtg gctctggctt ctgatcgctg ctccatccac 2280
ctgcagcttc aggggctggt ggaccctgca cgggagctgg gcaagctgca agccaagcga 2340
gttgaggccc agcggcaggc ccagcgtctg cgggaacgcc gtgctgcctc gggctatcct 2400
gtcaaggtgc cgctcgaagt ccaggaggca gatgaagcca agctccaaca gacagaagca 2460
gagctcagga aggtggatga ggccatcgcc ctattccaga agatgctgtg a          2511

<210> 166
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 166
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Val Leu Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg
    130                 135                 140                 
Trp Phe Val Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly
145                 150                 155                 160 
Glu Val Val Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly
                165                 170                 175     
Pro Glu Ala Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu
            180                 185                 190         
Ala Lys Lys Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile
        195                 200                 205             
Gln Gln Gln Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys
    210                 215                 220                 
Arg Glu Lys Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro
225                 230                 235                 240 
Pro Gly Glu Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser
                245                 250                 255     
Pro Arg Tyr Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly
            260                 265                 270         
Phe Phe Lys Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro
        275                 280                 285             
Arg Gly Val Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser
    290                 295                 300                 
Leu His Leu Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr
305                 310                 315                 320 
Arg Trp His Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys
                325                 330                 335     
Asp His Ala Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp
            340                 345                 350         
Arg Glu Gln Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu
        355                 360                 365             
Gln Glu Val Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His
    370                 375                 380                 
Gln Leu Lys Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe
385                 390                 395                 400 
Thr Met Asp Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg
                405                 410                 415     
Leu His Glu Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp
            420                 425                 430         
Ser Cys Thr Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys
        435                 440                 445             
Glu Leu Thr Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys
    450                 455                 460                 
Val Glu Phe Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser
465                 470                 475                 480 
Asp Ser Asp Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met
                485                 490                 495     
Leu Gly Asp Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln
            500                 505                 510         
His Leu Lys Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu
        515                 520                 525             
Pro Ile Val Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala
    530                 535                 540                 
Val Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln
545                 550                 555                 560 
Arg His Gly Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu
                565                 570                 575     
Ile Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg
            580                 585                 590         
Lys Ala Val Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile
        595                 600                 605             
Glu Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val
    610                 615                 620                 
Val Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met
625                 630                 635                 640 
Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu
                645                 650                 655     
Pro Glu Ala His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg
            660                 665                 670         
Glu Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala
        675                 680                 685             
Tyr Phe Val Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro
    690                 695                 700                 
Asp Gly Arg Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu
705                 710                 715                 720 
Lys Ala Ala Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln
                725                 730                 735     
Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro
            740                 745                 750         
Leu Ser Ile Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe
        755                 760                 765             
Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp
    770                 775                 780                 
Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro
785                 790                 795                 800 
Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg
                805                 810                 815     
Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile
            820                 825                 830         
Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn
        835                 840                 845             
Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp
    850                 855                 860                 
Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly
865                 870                 875                 880 
Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn
                885                 890                 895     
Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr
            900                 905                 910         
Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr
        915                 920                 925             
Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser
    930                 935                 940                 
Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr
945                 950                 955                 960 
Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu
                965                 970                 975     
Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val
            980                 985                 990         
Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu
        995                 1000                1005            
Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu
    1010                1015                1020                
Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser
1025                1030                1035               1040 
Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp
                1045                1050                1055    
Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala
            1060                1065                1070        
Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp
        1075                1080                1085            
Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala
    1090                1095                1100                
Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val
1105                1110                1115               1120 
Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala
                1125                1130                1135    
Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro
            1140                1145                1150        
Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg
        1155                1160                1165            
Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val
    1170                1175                1180                
Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln
1185                1190                1195               1200 
Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln
                1205                1210                1215    
Lys Met Leu
            


<210> 167
<211> 3660
<212> DNA
<213> Homo sapiens

<400> 167
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggtc ctagacccac ctgcccgccg gatctggaat 420
aatgtgactc gctggtttgt cacgtgtgtc cggcagccag aattccgagc cgtgctagga 480
gaagtggttc tatactcagg agccaggcct ctctctcatc agccaggccc cgaggctcct 540
gccctcccaa agacagctgc tcagctcaag aaagaggcaa agaaacggga gaagctagag 600
aaattccaac agaagcagaa gatccaacag cagcagccac ctccagggga gaagaaacca 660
aaaccagaga agagggagaa acgggatcct ggggtcatta cctatgacct cccaacccca 720
cccggggaaa agaaagatgt cagtggcccc atgcccgact cctacagccc tcggtatgtg 780
gaggctgcct ggtacccttg gtgggagcag cagggcttct tcaagccaga gtatgggcgt 840
cctaatgtgt cagcagcaaa tccccgaggt gtcttcatga tgtgcatccc accccccaat 900
gtgacaggct ccctgcacct gggccatgca ctcaccaacg ccatccagga ctccctgact 960
cgatggcacc gcatgcgtgg ggagaccacc ctgtggaacc ctggctgtga ccatgcaggt 1020
attgccaccc aggtggtggt ggagaagaag ctatggcgtg agcagggact gagccggcac 1080
cagctgggcc gcgaggcctt tctacaggaa gtctggaagt ggaaggagga gaaaggtgac 1140
cggatttacc accagttgaa gaagcttggc agctccttgg actgggatcg agcctgtttc 1200
accatggacc ctaaactctc agcagctgtg acagaggcct ttgtccggct tcacgaggaa 1260
ggcatcatct atcgcagtac ccgccttgtt aactggtcct gcaccctcaa ctccgccatc 1320
tctgacattg aggtggataa gaaggagctg acaggtcgca ccctgctctc cgtgcctggc 1380
tacaaggaga aggtggagtt cggggtcctc gtgtcctttg cctataaggt ccaaggctca 1440
gatagcgacg aggaggtggt ggtggcaaca actcggatcg agacaatgct gggagatgtg 1500
gctgtagctg tgcaccccaa agataccaga taccagcacc tgaaggggaa gaacgtgatc 1560
cacccattcc tgtctcggag ccttcccatt gtcttcgatg aatttgtgga catggacttt 1620
ggcacaggtg ctgtgaagat cacccccgca catgaccaaa atgactatga agttgggcag 1680
cggcacgggc tggaggccat cagcatcatg gactcccggg gggccctcat caatgtgcct 1740
ccgcctttcc tgggcctgcc caggtttgag gccaggaaag cggtgctggt ggcgctgaag 1800
gagcggggac tgttccgtgg cattgaggac aaccccatgg tggtgccact ttgcaaccgg 1860
tcgaaggacg tggtagagcc tctgctgcgg ccgcagtggt acgttcgctg cggggagatg 1920
gcccaggctg ccagcgccgc tgtgactcgg ggtgacctcc gcatcctgcc tgaggcccat 1980
cagcgcacat ggcatgcctg gatggacaac atccgggagt ggtgcatttc caggcagctg 2040
tggtggggcc atcgcatccc agcctacttt gtcactgtca gtgacccagc ggtgccccct 2100
ggggaggacc ctgatgggcg gtactgggtg agtggacgca atgaggcgga ggcccgggag 2160
aaggcagcca aggagttcgg agtgtcccct gacaagatca gtctccagca agatgaggat 2220
gtattggata cctggttctc ctctggcctc ttccccttat ccattttggg ctggcccaac 2280
cagtcagaag acctgagtgt gttctacccc gggacactgc tggagaccgg tcatgacatc 2340
ctcttcttct gggtggcccg gatggtcatg ctgggcctga agctcacggg caggctgccc 2400
tttagagagg tctacctcca tgccatcgtg cgagatgctc acggccggaa gatgagcaag 2460
tctctaggca atgtcatcga tcccctggac gtcatctatg gaatctccct gcagggcctc 2520
cacaaccagc tgctgaacag caacctggat cccagcgagg tggagaaggc caaagaaggg 2580
cagaaagctg acttcccagc ggggattcct gaatgtggca ccgatgctct ccggtttgga 2640
ttatgtgcct acatgtccca gggtcgtgac atcaacctgg atgtgaaccg gatactgggt 2700
taccgccact tctgcaacaa gctctggaat gccaccaagt ttgcccttcg tggccttggg 2760
aagggttttg tgccctcacc cacctcccag cccggaggcc atgagagcct ggtggaccgc 2820
tggatccgca gccgcctgac agaggctgtg aggctcagca atcaaggctt ccaggcctac 2880
gacttcccgg ccgtcaccac tgcccagtac agcttctggc tctatgagct ctgtgatgtc 2940
tacttggagt gcctgaaacc tgtactgaat ggggtggacc aggtggcagc tgagtgtgcc 3000
cgccagaccc tgtacacttg cctggacgtt ggcctgcggc tgctctcacc cttcatgccc 3060
ttcgtgacgg aggagctgtt ccagaggctg ccccggagga tgccgcaagc tccccctagc 3120
ctctgtgtta ccccctaccc ggagccctca gagtgctcct ggaaggaccc cgaggcagaa 3180
gccgcccttg agctggcgct aagcatcacg cgagccgtgc gctccctgcg ggccgactac 3240
aacctcaccc ggatccggcc tgactgtttc ctggaagtgg cggatgaggc cacgggcgcc 3300
ctggcatcgg cggtgtcggg ctacgtgcag gccctggcca gcgcaggtgt ggtggctgtt 3360
ctggccctgg gggctcccgc cccccagggt tgcgctgtgg ctctggcttc tgatcgctgc 3420
tccatccacc tgcagcttca ggggctggtg gaccctgcac gggagctggg caagctgcaa 3480
gccaagcgag ttgaggccca gcggcaggcc cagcgtctgc gggaacgccg tgctgcctcg 3540
ggctatcctg tcaaggtgcc gctcgaagtc caggaggcag atgaagccaa gctccaacag 3600
acagaagcag agctcaggaa ggtggatgag gccatcgccc tattccagaa gatgctgtga 3660


<210> 168
<211> 580
<212> PRT
<213> Homo sapiens

<400> 168
Met Ala Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile
 1               5                  10                  15      
Leu Pro Glu Ala His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile
            20                  25                  30          
Arg Glu Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro
        35                  40                  45              
Ala Tyr Phe Val Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp
    50                  55                  60                  
Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg
65                  70                  75                  80  
Glu Lys Ala Ala Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu
                85                  90                  95      
Gln Gln Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe
            100                 105                 110         
Pro Leu Ser Ile Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val
        115                 120                 125             
Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe
    130                 135                 140                 
Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu
145                 150                 155                 160 
Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly
                165                 170                 175     
Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val
            180                 185                 190         
Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser
        195                 200                 205             
Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala
    210                 215                 220                 
Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe
225                 230                 235                 240 
Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val
                245                 250                 255     
Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala
            260                 265                 270         
Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro
        275                 280                 285             
Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg
    290                 295                 300                 
Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala
305                 310                 315                 320 
Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr
                325                 330                 335     
Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly
            340                 345                 350         
Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys
        355                 360                 365             
Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr
    370                 375                 380                 
Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro
385                 390                 395                 400 
Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys
                405                 410                 415     
Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg
            420                 425                 430         
Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro
        435                 440                 445             
Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser
    450                 455                 460                 
Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala
465                 470                 475                 480 
Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu
                485                 490                 495     
Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp
            500                 505                 510         
Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln
        515                 520                 525             
Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro
    530                 535                 540                 
Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln
545                 550                 555                 560 
Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe
                565                 570                 575     
Gln Lys Met Leu
            580 


<210> 169
<211> 1743
<212> DNA
<213> Homo sapiens

<400> 169
atggcccagg ctgccagcgc cgctgtgact cggggtgacc tccgcatcct gcctgaggcc 60
catcagcgca catggcatgc ctggatggac aacatccggg agtggtgcat ttccaggcag 120
ctgtggtggg gccatcgcat cccagcctac tttgtcactg tcagtgaccc agcggtgccc 180
cctggggagg accctgatgg gcggtactgg gtgagtggac gcaatgaggc ggaggcccgg 240
gagaaggcag ccaaggagtt cggagtgtcc cctgacaaga tcagtctcca gcaagatgag 300
gatgtattgg atacctggtt ctcctctggc ctcttcccct tatccatttt gggctggccc 360
aaccagtcag aagacctgag tgtgttctac cccgggacac tgctggagac cggtcatgac 420
atcctcttct tctgggtggc ccggatggtc atgctgggcc tgaagctcac gggcaggctg 480
ccctttagag aggtctacct ccatgccatc gtgcgagatg ctcacggccg gaagatgagc 540
aagtctctag gcaatgtcat cgatcccctg gacgtcatct atggaatctc cctgcagggc 600
ctccacaacc agctgctgaa cagcaacctg gatcccagcg aggtggagaa ggccaaagaa 660
gggcagaaag ctgacttccc agcggggatt cctgaatgtg gcaccgatgc tctccggttt 720
ggattatgtg cctacatgtc ccagggtcgt gacatcaacc tggatgtgaa ccggatactg 780
ggttaccgcc acttctgcaa caagctctgg aatgccacca agtttgccct tcgtggcctt 840
gggaagggtt ttgtgccctc acccacctcc cagcccggag gccatgagag cctggtggac 900
cgctggatcc gcagccgcct gacagaggct gtgaggctca gcaatcaagg cttccaggcc 960
tacgacttcc cggccgtcac cactgcccag tacagcttct ggctctatga gctctgtgat 1020
gtctacttgg agtgcctgaa acctgtactg aatggggtgg accaggtggc agctgagtgt 1080
gcccgccaga ccctgtacac ttgcctggac gttggcctgc ggctgctctc acccttcatg 1140
cccttcgtga cggaggagct gttccagagg ctgccccgga ggatgccgca agctccccct 1200
agcctctgtg ttacccccta cccggagccc tcagagtgct cctggaagga ccccgaggca 1260
gaagccgccc ttgagctggc gctaagcatc acgcgagccg tgcgctccct gcgggccgac 1320
tacaacctca cccggatccg gcctgactgt ttcctggaag tggcggatga ggccacgggc 1380
gccctggcat cggcggtgtc gggctacgtg caggccctgg ccagcgcagg tgtggtggct 1440
gttctggccc tgggggctcc cgccccccag ggttgcgctg tggctctggc ttctgatcgc 1500
tgctccatcc acctgcagct tcaggggctg gtggaccctg cacgggagct gggcaagctg 1560
caagccaagc gagttgaggc ccagcggcag gcccagcgtc tgcgggaacg ccgtgctgcc 1620
tcgggctatc ctgtcaaggt gccgctcgaa gtccaggagg cagatgaagc caagctccaa 1680
cagacagaag cagagctcag gaaggtggat gaggccatcg ccctattcca gaagatgctg 1740
tga                                                               1743

<210> 170
<211> 1202
<212> PRT
<213> Homo sapiens

<400> 170
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Gly Ala Val
        515                 520                 525             
Lys Ile Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg
    530                 535                 540                 
His Gly Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile
545                 550                 555                 560 
Asn Val Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys
                565                 570                 575     
Ala Val Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu
            580                 585                 590         
Asp Asn Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val
        595                 600                 605             
Glu Pro Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala
    610                 615                 620                 
Gln Ala Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro
625                 630                 635                 640 
Glu Ala His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu
                645                 650                 655     
Trp Cys Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr
            660                 665                 670         
Phe Val Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp
        675                 680                 685             
Gly Arg Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys
    690                 695                 700                 
Ala Ala Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln
705                 710                 715                 720 
Asp Glu Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Leu
                725                 730                 735     
Ser Ile Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe Tyr
            740                 745                 750         
Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val
        755                 760                 765             
Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe
    770                 775                 780                 
Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys
785                 790                 795                 800 
Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr
                805                 810                 815     
Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu
            820                 825                 830         
Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe
        835                 840                 845             
Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu
    850                 855                 860                 
Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg
865                 870                 875                 880 
Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys
                885                 890                 895     
Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser
            900                 905                 910         
Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg
        915                 920                 925             
Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp
    930                 935                 940                 
Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu
945                 950                 955                 960 
Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp
                965                 970                 975     
Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp
            980                 985                 990         
Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu
        995                 1000                1005            
Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu
    1010                1015                1020                
Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro
1025                1030                1035               1040 
Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val
                1045                1050                1055    
Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys
            1060                1065                1070        
Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val
        1075                1080                1085            
Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu
    1090                1095                1100                
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser
1105                1110                1115               1120 
Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala
                1125                1130                1135    
Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln
            1140                1145                1150        
Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys
        1155                1160                1165            
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
    1170                1175                1180                
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
1185                1190                1195               1200 
Met Leu
        


<210> 171
<211> 3609
<212> DNA
<213> Homo sapiens

<400> 171
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcaggtgc tgtgaagatc acccccgcac atgaccaaaa tgactatgaa 1620
gttgggcagc ggcacgggct ggaggccatc agcatcatgg actcccgggg ggccctcatc 1680
aatgtgcctc cgcctttcct gggcctgccc aggtttgagg ccaggaaagc ggtgctggtg 1740
gcgctgaagg agcggggact gttccgtggc attgaggaca accccatggt ggtgccactt 1800
tgcaaccggt cgaaggacgt ggtagagcct ctgctgcggc cgcagtggta cgttcgctgc 1860
ggggagatgg cccaggctgc cagcgccgct gtgactcggg gtgacctccg catcctgcct 1920
gaggcccatc agcgcacatg gcatgcctgg atggacaaca tccgggagtg gtgcatttcc 1980
aggcagctgt ggtggggcca tcgcatccca gcctactttg tcactgtcag tgacccagcg 2040
gtgccccctg gggaggaccc tgatgggcgg tactgggtga gtggacgcaa tgaggcggag 2100
gcccgggaga aggcagccaa ggagttcgga gtgtcccctg acaagatcag tctccagcaa 2160
gatgaggatg tattggatac ctggttctcc tctggcctct tccccttatc cattttgggc 2220
tggcccaacc agtcagaaga cctgagtgtg ttctaccccg ggacactgct ggagaccggt 2280
catgacatcc tcttcttctg ggtggcccgg atggtcatgc tgggcctgaa gctcacgggc 2340
aggctgccct ttagagaggt ctacctccat gccatcgtgc gagatgctca cggccggaag 2400
atgagcaagt ctctaggcaa tgtcatcgat cccctggacg tcatctatgg aatctccctg 2460
cagggcctcc acaaccagct gctgaacagc aacctggatc ccagcgaggt ggagaaggcc 2520
aaagaagggc agaaagctga cttcccagcg gggattcctg aatgtggcac cgatgctctc 2580
cggtttggat tatgtgccta catgtcccag ggtcgtgaca tcaacctgga tgtgaaccgg 2640
atactgggtt accgccactt ctgcaacaag ctctggaatg ccaccaagtt tgcccttcgt 2700
ggccttggga agggttttgt gccctcaccc acctcccagc ccggaggcca tgagagcctg 2760
gtggaccgct ggatccgcag ccgcctgaca gaggctgtga ggctcagcaa tcaaggcttc 2820
caggcctacg acttcccggc cgtcaccact gcccagtaca gcttctggct ctatgagctc 2880
tgtgatgtct acttggagtg cctgaaacct gtactgaatg gggtggacca ggtggcagct 2940
gagtgtgccc gccagaccct gtacacttgc ctggacgttg gcctgcggct gctctcaccc 3000
ttcatgccct tcgtgacgga ggagctgttc cagaggctgc cccggaggat gccgcaagct 3060
ccccctagcc tctgtgttac cccctacccg gagccctcag agtgctcctg gaaggacccc 3120
gaggcagaag ccgcccttga gctggcgcta agcatcacgc gagccgtgcg ctccctgcgg 3180
gccgactaca acctcacccg gatccggcct gactgtttcc tggaagtggc ggatgaggcc 3240
acgggcgccc tggcatcggc ggtgtcgggc tacgtgcagg ccctggccag cgcaggtgtg 3300
gtggctgttc tggccctggg ggctcccgcc ccccagggtt gcgctgtggc tctggcttct 3360
gatcgctgct ccatccacct gcagcttcag gggctggtgg accctgcacg ggagctgggc 3420
aagctgcaag ccaagcgagt tgaggcccag cggcaggccc agcgtctgcg ggaacgccgt 3480
gctgcctcgg gctatcctgt caaggtgccg ctcgaagtcc aggaggcaga tgaagccaag 3540
ctccaacaga cagaagcaga gctcaggaag gtggatgagg ccatcgccct attccagaag 3600
atgctgtga                                                         3609

<210> 172
<211> 650
<212> PRT
<213> Homo sapiens

<400> 172
Met Asp Ser Arg Gly Ala Leu Ile Asn Val Pro Pro Pro Phe Leu Gly
 1               5                  10                  15      
Leu Pro Arg Phe Glu Ala Arg Lys Ala Val Leu Val Ala Leu Lys Glu
            20                  25                  30          
Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn Pro Met Val Val Pro Leu
        35                  40                  45              
Cys Asn Arg Ser Lys Asp Val Val Glu Pro Leu Leu Arg Pro Gln Trp
    50                  55                  60                  
Tyr Val Arg Cys Gly Glu Met Ala Gln Ala Ala Ser Ala Ala Val Thr
65                  70                  75                  80  
Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala His Gln Arg Thr Trp His
                85                  90                  95      
Ala Trp Met Asp Asn Ile Arg Glu Trp Cys Ile Ser Arg Gln Leu Trp
            100                 105                 110         
Trp Gly His Arg Ile Pro Ala Tyr Phe Val Thr Val Ser Asp Pro Ala
        115                 120                 125             
Val Pro Pro Gly Glu Asp Pro Asp Gly Arg Tyr Trp Val Ser Gly Arg
    130                 135                 140                 
Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala Lys Glu Phe Gly Val Ser
145                 150                 155                 160 
Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu Asp Val Leu Asp Thr Trp
                165                 170                 175     
Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile Leu Gly Trp Pro Asn Gln
            180                 185                 190         
Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly
        195                 200                 205             
His Asp Ile Leu Phe Phe Trp Val Ala Arg Met Val Met Leu Gly Leu
    210                 215                 220                 
Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile
225                 230                 235                 240 
Val Arg Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val
                245                 250                 255     
Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His
            260                 265                 270         
Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala
        275                 280                 285             
Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly
    290                 295                 300                 
Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg
305                 310                 315                 320 
Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys
                325                 330                 335     
Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys
            340                 345                 350         
Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu
        355                 360                 365             
Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser
    370                 375                 380                 
Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln
385                 390                 395                 400 
Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu
                405                 410                 415     
Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg
            420                 425                 430         
Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro
        435                 440                 445             
Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg
    450                 455                 460                 
Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro
465                 470                 475                 480 
Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu
                485                 490                 495     
Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn
            500                 505                 510         
Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala
        515                 520                 525             
Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala
    530                 535                 540                 
Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln
545                 550                 555                 560 
Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln
                565                 570                 575     
Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala
            580                 585                 590         
Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg
        595                 600                 605             
Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala
    610                 615                 620                 
Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp
625                 630                 635                 640 
Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
                645                 650 


<210> 173
<211> 1953
<212> DNA
<213> Homo sapiens

<400> 173
atggactccc ggggggccct catcaatgtg cctccgcctt tcctgggcct gcccaggttt 60
gaggccagga aagcggtgct ggtggcgctg aaggagcggg gactgttccg tggcattgag 120
gacaacccca tggtggtgcc actttgcaac cggtcgaagg acgtggtaga gcctctgctg 180
cggccgcagt ggtacgttcg ctgcggggag atggcccagg ctgccagcgc cgctgtgact 240
cggggtgacc tccgcatcct gcctgaggcc catcagcgca catggcatgc ctggatggac 300
aacatccggg agtggtgcat ttccaggcag ctgtggtggg gccatcgcat cccagcctac 360
tttgtcactg tcagtgaccc agcggtgccc cctggggagg accctgatgg gcggtactgg 420
gtgagtggac gcaatgaggc ggaggcccgg gagaaggcag ccaaggagtt cggagtgtcc 480
cctgacaaga tcagtctcca gcaagatgag gatgtattgg atacctggtt ctcctctggc 540
ctcttcccct tatccatttt gggctggccc aaccagtcag aagacctgag tgtgttctac 600
cccgggacac tgctggagac cggtcatgac atcctcttct tctgggtggc ccggatggtc 660
atgctgggcc tgaagctcac gggcaggctg ccctttagag aggtctacct ccatgccatc 720
gtgcgagatg ctcacggccg gaagatgagc aagtctctag gcaatgtcat cgatcccctg 780
gacgtcatct atggaatctc cctgcagggc ctccacaacc agctgctgaa cagcaacctg 840
gatcccagcg aggtggagaa ggccaaagaa gggcagaaag ctgacttccc agcggggatt 900
cctgaatgtg gcaccgatgc tctccggttt ggattatgtg cctacatgtc ccagggtcgt 960
gacatcaacc tggatgtgaa ccggatactg ggttaccgcc acttctgcaa caagctctgg 1020
aatgccacca agtttgccct tcgtggcctt gggaagggtt ttgtgccctc acccacctcc 1080
cagcccggag gccatgagag cctggtggac cgctggatcc gcagccgcct gacagaggct 1140
gtgaggctca gcaatcaagg cttccaggcc tacgacttcc cggccgtcac cactgcccag 1200
tacagcttct ggctctatga gctctgtgat gtctacttgg agtgcctgaa acctgtactg 1260
aatggggtgg accaggtggc agctgagtgt gcccgccaga ccctgtacac ttgcctggac 1320
gttggcctgc ggctgctctc acccttcatg cccttcgtga cggaggagct gttccagagg 1380
ctgccccgga ggatgccgca agctccccct agcctctgtg ttacccccta cccggagccc 1440
tcagagtgct cctggaagga ccccgaggca gaagccgccc ttgagctggc gctaagcatc 1500
acgcgagccg tgcgctccct gcgggccgac tacaacctca cccggatccg gcctgactgt 1560
ttcctggaag tggcggatga ggccacgggc gccctggcat cggcggtgtc gggctacgtg 1620
caggccctgg ccagcgcagg tgtggtggct gttctggccc tgggggctcc cgccccccag 1680
ggttgcgctg tggctctggc ttctgatcgc tgctccatcc acctgcagct tcaggggctg 1740
gtggaccctg cacgggagct gggcaagctg caagccaagc gagttgaggc ccagcggcag 1800
gcccagcgtc tgcgggaacg ccgtgctgcc tcgggctatc ctgtcaaggt gccgctcgaa 1860
gtccaggagg cagatgaagc caagctccaa cagacagaag cagagctcag gaaggtggat 1920
gaggccatcg ccctattcca gaagatgctg tga                              1953

<210> 174
<211> 1241
<212> PRT
<213> Homo sapiens

<400> 174
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu
    130                 135                 140                 
Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala
145                 150                 155                 160 
Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu
                165                 170                 175     
Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val
            180                 185                 190         
Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val
        195                 200                 205             
Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala
    210                 215                 220                 
Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln
                245                 250                 255     
Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys
            260                 265                 270         
Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu
        275                 280                 285             
Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr
    290                 295                 300                 
Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys
305                 310                 315                 320 
Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val
                325                 330                 335     
Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu
            340                 345                 350         
Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His
        355                 360                 365             
Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala
    370                 375                 380                 
Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln
385                 390                 395                 400 
Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val
                405                 410                 415     
Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys
            420                 425                 430         
Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp
        435                 440                 445             
Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu
    450                 455                 460                 
Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr
465                 470                 475                 480 
Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr
                485                 490                 495     
Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe
            500                 505                 510         
Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp
        515                 520                 525             
Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp
    530                 535                 540                 
Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys
545                 550                 555                 560 
Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val
                565                 570                 575     
Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile
            580                 585                 590         
Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly
        595                 600                 605             
Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val
    610                 615                 620                 
Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val
625                 630                 635                 640 
Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn
                645                 650                 655     
Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro
            660                 665                 670         
Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala
        675                 680                 685             
Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala
    690                 695                 700                 
His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys
705                 710                 715                 720 
Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val
                725                 730                 735     
Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg
            740                 745                 750         
Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala
        755                 760                 765             
Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu
    770                 775                 780                 
Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile
785                 790                 795                 800 
Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly
                805                 810                 815     
Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val Ala Arg
            820                 825                 830         
Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu
        835                 840                 845             
Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser
    850                 855                 860                 
Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile
865                 870                 875                 880 
Ser Leu Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr
                885                 890                 895     
Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp
            900                 905                 910         
Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn
        915                 920                 925             
Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly
    930                 935                 940                 
Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val
945                 950                 955                 960 
Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn
                965                 970                 975     
Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr
            980                 985                 990         
Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys
        995                 1000                1005            
Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln
    1010                1015                1020                
Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe
1025                1030                1035               1040 
Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met
                1045                1050                1055    
Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser
            1060                1065                1070        
Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala
        1075                1080                1085            
Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu
    1090                1095                1100                
Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr
1105                1110                1115               1120 
Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser
                1125                1130                1135    
Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly
            1140                1145                1150        
Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu
        1155                1160                1165            
Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys
    1170                1175                1180                
Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala
1185                1190                1195               1200 
Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp
                1205                1210                1215    
Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu
            1220                1225                1230        
Ala Ile Ala Leu Phe Gln Lys Met Leu
        1235                1240    


<210> 175
<211> 3726
<212> DNA
<213> Homo sapiens

<400> 175
atgtccaccc tctacgtctc ccctcaccca gatgccttcc ccagcctccg agccctcata 60
gccgctcgct atggggaggc tggggagggt cccggatggg gaggagccca cccccgcatc 120
tgtctccagc cacccccgac tagcaggact ccctttcccc caccccgcct gccggccctg 180
gagcaggggc ccggtgggct ctgggtgtgg ggggccacgg ctgtggccca gctgctgtgg 240
ccagcaggcc tggggggccc agggggcagc cgggcggctg tccttgtcca acagtgggtc 300
agttacgccg acacggagtt aataccagct gcctgtggag caacgctgcc ggccctggga 360
ctccgaagct cggcccagga cccccaggct gtgctggggg ccctgggcag ggccctgagc 420
cccttggagg agtggcttcg gctgcacacc tacttggccg gggaggcccc cactctggct 480
gacctggcgg ctgtcacagc cttgctgctg cctttccgat acgtcctaga cccacctgcc 540
cgccggatct ggaataatgt gactcgctgg tttgtcacgt gtgtccggca gccagaattc 600
cgagccgtgc taggagaagt ggttctatac tcaggagcca ggcctctctc tcatcagcca 660
ggccccgagg ctcctgccct cccaaagaca gctgctcagc tcaagaaaga ggcaaagaaa 720
cgggagaagc tagagaaatt ccaacagaag cagaagatcc aacagcagca gccacctcca 780
ggggagaaga aaccaaaacc agagaagagg gagaaacggg atcctggggt cattacctat 840
gacctcccaa ccccacccgg ggaaaagaaa gatgtcagtg gccccatgcc cgactcctac 900
agccctcggt atgtggaggc tgcctggtac ccttggtggg agcagcaggg cttcttcaag 960
ccagagtatg ggcgtcctaa tgtgtcagca gcaaatcccc gaggtgtctt catgatgtgc 1020
atcccacccc ccaatgtgac aggctccctg cacctgggcc atgcactcac caacgccatc 1080
caggactccc tgactcgatg gcaccgcatg cgtggggaga ccaccctgtg gaaccctggc 1140
tgtgaccatg caggtattgc cacccaggtg gtggtggaga agaagctatg gcgtgagcag 1200
ggactgagcc ggcaccagct gggccgcgag gcctttctac aggaagtctg gaagtggaag 1260
gaggagaaag gtgaccggat ttaccaccag ttgaagaagc ttggcagctc cttggactgg 1320
gatcgagcct gtttcaccat ggaccctaaa ctctcagcag ctgtgacaga ggcctttgtc 1380
cggcttcacg aggaaggcat catctatcgc agtacccgcc ttgttaactg gtcctgcacc 1440
ctcaactccg ccatctctga cattgaggtg gataagaagg agctgacagg tcgcaccctg 1500
ctctccgtgc ctggctacaa ggagaaggtg gagttcgggg tcctcgtgtc ctttgcctat 1560
aaggtccaag gctcagatag cgacgaggag gtggtggtgg caacaactcg gatcgagaca 1620
atgctgggag atgtggctgt agctgtgcac cccaaagata ccagatacca gcacctgaag 1680
gggaagaacg tgatccaccc attcctgtct cggagccttc ccattgtctt cgatgaattt 1740
gtggacatgg actttggcac aggtgctgtg aagatcaccc ccgcacatga ccaaaatgac 1800
tatgaagttg ggcagcggca cgggctggag gccatcagca tcatggactc ccggggggcc 1860
ctcatcaatg tgcctccgcc tttcctgggc ctgcccaggt ttgaggccag gaaagcggtg 1920
ctggtggcgc tgaaggagcg gggactgttc cgtggcattg aggacaaccc catggtggtg 1980
ccactttgca accggtcgaa ggacgtggta gagcctctgc tgcggccgca gtggtacgtt 2040
cgctgcgggg agatggccca ggctgccagc gccgctgtga ctcggggtga cctccgcatc 2100
ctgcctgagg cccatcagcg cacatggcat gcctggatgg acaacatccg ggagtggtgc 2160
atttccaggc agctgtggtg gggccatcgc atcccagcct actttgtcac tgtcagtgac 2220
ccagcggtgc cccctgggga ggaccctgat gggcggtact gggtgagtgg acgcaatgag 2280
gcggaggccc gggagaaggc agccaaggag ttcggagtgt cccctgacaa gatcagtctc 2340
cagcaagatg aggatgtatt ggatacctgg ttctcctctg gcctcttccc cttatccatt 2400
ttgggctggc ccaaccagtc agaagacctg agtgtgttct accccgggac actgctggag 2460
accggtcatg acatcctctt cttctgggtg gcccggatgg tcatgctggg cctgaagctc 2520
acgggcaggc tgccctttag agaggtctac ctccatgcca tcgtgcgaga tgctcacggc 2580
cggaagatga gcaagtctct aggcaatgtc atcgatcccc tggacgtcat ctatggaatc 2640
tccctgcaga aagctgactt cccagcgggg attcctgaat gtggcaccga tgctctccgg 2700
tttggattat gtgcctacat gtcccagggt cgtgacatca acctggatgt gaaccggata 2760
ctgggttacc gccacttctg caacaagctc tggaatgcca ccaagtttgc ccttcgtggc 2820
cttgggaagg gttttgtgcc ctcacccacc tcccagcccg gaggccatga gagcctggtg 2880
gaccgctgga tccgcagccg cctgacagag gctgtgaggc tcagcaatca aggcttccag 2940
gcctacgact tcccggccgt caccactgcc cagtacagct tctggctcta tgagctctgt 3000
gatgtctact tggagtgcct gaaacctgta ctgaatgggg tggaccaggt ggcagctgag 3060
tgtgcccgcc agaccctgta cacttgcctg gacgttggcc tgcggctgct ctcacccttc 3120
atgcccttcg tgacggagga gctgttccag aggctgcccc ggaggatgcc gcaagctccc 3180
cctagcctct gtgttacccc ctacccggag ccctcagagt gctcctggaa ggaccccgag 3240
gcagaagccg cccttgagct ggcgctaagc atcacgcgag ccgtgcgctc cctgcgggcc 3300
gactacaacc tcacccggat ccggcctgac tgtttcctgg aagtggcgga tgaggccacg 3360
ggcgccctgg catcggcggt gtcgggctac gtgcaggccc tggccagcgc aggtgtggtg 3420
gctgttctgg ccctgggggc tcccgccccc cagggttgcg ctgtggctct ggcttctgat 3480
cgctgctcca tccacctgca gcttcagggg ctggtggacc ctgcacggga gctgggcaag 3540
ctgcaagcca agcgagttga ggcccagcgg caggcccagc gtctgcggga acgccgtgct 3600
gcctcgggct atcctgtcaa ggtgccgctc gaagtccagg aggcagatga agccaagctc 3660
caacagacag aagcagagct caggaaggtg gatgaggcca tcgccctatt ccagaagatg 3720
ctgtga                                                            3726

<210> 176
<211> 201
<212> PRT
<213> Homo sapiens

<400> 176
Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met
 1               5                  10                  15      
Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser
            20                  25                  30          
Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala
        35                  40                  45              
Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu
    50                  55                  60                  
Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr
65                  70                  75                  80  
Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser
                85                  90                  95      
Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly
            100                 105                 110         
Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu
        115                 120                 125             
Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys
    130                 135                 140                 
Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala
145                 150                 155                 160 
Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp
                165                 170                 175     
Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu
            180                 185                 190         
Ala Ile Ala Leu Phe Gln Lys Met Leu
        195                 200     


<210> 177
<211> 606
<212> DNA
<213> Homo sapiens

<400> 177
atgcccttcg tgacggagga gctgttccag aggctgcccc ggaggatgcc gcaagctccc 60
cctagcctct gtgttacccc ctacccggag ccctcagagt gctcctggaa ggaccccgag 120
gcagaagccg cccttgagct ggcgctaagc atcacgcgag ccgtgcgctc cctgcgggcc 180
gactacaacc tcacccggat ccggcctgac tgtttcctgg aagtggcgga tgaggccacg 240
ggcgccctgg catcggcggt gtcgggctac gtgcaggccc tggccagcgc aggtgtggtg 300
gctgttctgg ccctgggggc tcccgccccc cagggttgcg ctgtggctct ggcttctgat 360
cgctgctcca tccacctgca gcttcagggg ctggtggacc ctgcacggga gctgggcaag 420
ctgcaagcca agcgagttga ggcccagcgg caggcccagc gtctgcggga acgccgtgct 480
gcctcgggct atcctgtcaa ggtgccgctc gaagtccagg aggcagatga agccaagctc 540
caacagacag aagcagagct caggaaggtg gatgaggcca tcgccctatt ccagaagatg 600
ctgtga                                                            606

<210> 178
<211> 50
<212> DNA
<213> Homo sapiens

<400> 178
gccaggcctc tctctcatca gccagggcct ccacaaccag ctgctgaaca            50

<210> 179
<211> 50
<212> DNA
<213> Homo sapiens

<400> 179
acagcagcag ccacctccag gggagaaagc tgacttccca gcggggattc            50

<210> 180
<211> 16
<212> PRT
<213> Homo sapiens

<400> 180
Gln Gln Gln Pro Pro Pro Gly Glu Lys Ala Asp Phe Pro Ala Gly Ile
 1               5                  10                  15      


<210> 181
<211> 50
<212> DNA
<213> Homo sapiens

<400> 181
ccgaagctcg gcccaggacc cccagcccgg aggccatgag agcctggtgg            50

<210> 182
<211> 16
<212> PRT
<213> Homo sapiens

<400> 182
Arg Ser Ser Ala Gln Asp Pro Gln Pro Gly Gly His Glu Ser Leu Val
 1               5                  10                  15      


<210> 183
<211> 50
<212> DNA
<213> Homo sapiens

<400> 183
catcaatgtg cctccgcctt tcctgccggt cgaaggacgt ggtagagcct            50

<210> 184
<211> 16
<212> PRT
<213> Homo sapiens

<400> 184
Ile Asn Val Pro Pro Pro Phe Leu Pro Val Glu Gly Arg Gly Arg Ala
 1               5                  10                  15      


<210> 185
<211> 50
<212> DNA
<213> Homo sapiens

<400> 185
atccattttg ggctggccca accaggtcta cctccatgcc atcgtgcgag            50

<210> 186
<211> 16
<212> PRT
<213> Homo sapiens

<400> 186
Ser Ile Leu Gly Trp Pro Asn Gln Val Tyr Leu His Ala Ile Val Arg
 1               5                  10                  15      


<210> 187
<211> 50
<212> DNA
<213> Homo sapiens

<400> 187
tttgtggaca tggactttgg cacagggagt ggtgcatttc caggcagctg            50

<210> 188
<211> 50
<212> DNA
<213> Homo sapiens

<400> 188
cctgacaaga tcagtctcca gcaaggtcta cctccatgcc atcgtgcgag            50

<210> 189
<211> 16
<212> PRT
<213> Homo sapiens

<400> 189
Leu Thr Arg Ser Val Ser Ser Lys Val Tyr Leu His Ala Ile Val Arg
 1               5                  10                  15      


<210> 190
<211> 50
<212> DNA
<213> Homo sapiens

<400> 190
cctgacaaga tcagtctcca gcaagtcaga agacctgagt gtgttctacc            50

<210> 191
<211> 16
<212> PRT
<213> Homo sapiens

<400> 191
Leu Thr Arg Ser Val Ser Ser Lys Ser Glu Asp Leu Ser Val Phe Tyr
 1               5                  10                  15      


<210> 192
<211> 50
<212> DNA
<213> Homo sapiens

<400> 192
ccgaagctcg gcccaggacc cccagatagc gacgaggagg tggtggtggc            50

<210> 193
<211> 50
<212> DNA
<213> Homo sapiens

<400> 193
ccgaagctcg gcccaggacc cccagcacct gaaggggaag aacgtgatcc            50

<210> 194
<211> 16
<212> PRT
<213> Homo sapiens

<400> 194
Arg Ser Ser Ala Gln Asp Pro Gln His Leu Lys Gly Lys Asn Val Ile
 1               5                  10                  15      


<210> 195
<211> 50
<212> DNA
<213> Homo sapiens

<400> 195
ccgaagctcg gcccaggacc cccaggtcct agacccacct gcccgccgga            50

<210> 196
<211> 16
<212> PRT
<213> Homo sapiens

<400> 196
Arg Ser Ser Ala Gln Asp Pro Gln Val Leu Asp Pro Pro Ala Arg Arg
 1               5                  10                  15      


<210> 197
<211> 50
<212> DNA
<213> Homo sapiens

<400> 197
ccgaagctcg gcccaggacc cccagccggt cgaaggacgt ggtagagcct            50

<210> 198
<211> 50
<212> DNA
<213> Homo sapiens

<400> 198
tttgcctata aggtccaagg ctcaggtgct gtgaagatca cccccgcaca            50

<210> 199
<211> 16
<212> PRT
<213> Homo sapiens

<400> 199
Phe Ala Tyr Lys Val Gln Gly Ser Gly Ala Val Lys Ile Thr Pro Ala
 1               5                  10                  15      


<210> 200
<211> 50
<212> DNA
<213> Homo sapiens

<400> 200
gcaccccaaa gataccagat accaggtgct gtgaagatca cccccgcaca            50

<210> 201
<211> 50
<212> DNA
<213> Homo sapiens

<400> 201
cgtcatctat ggaatctccc tgcagaaagc tgacttccca gcggggattc            50

<210> 202
<211> 16
<212> PRT
<213> Homo sapiens

<400> 202
Val Ile Tyr Gly Ile Ser Leu Gln Lys Ala Asp Phe Pro Ala Gly Ile
 1               5                  10                  15      


<210> 203
<211> 50
<212> DNA
<213> Homo sapiens

<400> 203
ggtggagaag gccaaagaag ggcaggtcgt gacatcaacc tggatgtgaa            50

<210> 204
<211> 411
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 204
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu
            20                  25                  30          
His Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys
        35                  40                  45              
Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys
    50                  55                  60                  
Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly
65                  70                  75                  80  
Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe
                85                  90                  95      
Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly
            100                 105                 110         
Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser
        115                 120                 125             
Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu
    130                 135                 140                 
Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala
145                 150                 155                 160 
Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys
                165                 170                 175     
Leu Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala
            180                 185                 190         
Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser
        195                 200                 205             
Pro Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg
    210                 215                 220                 
Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu
225                 230                 235                 240 
Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu
                245                 250                 255     
Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr
            260                 265                 270         
Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu
        275                 280                 285             
Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu
    290                 295                 300                 
Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro
305                 310                 315                 320 
Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu
                325                 330                 335     
Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln
            340                 345                 350         
Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg
        355                 360                 365             
Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu
    370                 375                 380                 
Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val
385                 390                 395                 400 
Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
                405                 410     


<210> 205
<211> 411
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 205
Met Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu
 1               5                  10                  15      
Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly
            20                  25                  30          
Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala
        35                  40                  45              
Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn
    50                  55                  60                  
Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu
65                  70                  75                  80  
Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val
                85                  90                  95      
Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg
            100                 105                 110         
Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly
        115                 120                 125             
Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe
    130                 135                 140                 
Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val
145                 150                 155                 160 
Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu
                165                 170                 175     
Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro
            180                 185                 190         
Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln
        195                 200                 205             
Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys
    210                 215                 220                 
Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser
225                 230                 235                 240 
Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg
                245                 250                 255     
Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala
            260                 265                 270         
Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly
        275                 280                 285             
Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala
    290                 295                 300                 
Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly
305                 310                 315                 320 
Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val
                325                 330                 335     
Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser
            340                 345                 350         
Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala
        355                 360                 365             
Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile
    370                 375                 380                 
Ala Leu Phe Gln Lys Met Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu
385                 390                 395                 400 
Gly Leu Asp Ser Thr His His His His His His
                405                 410     


<210> 206
<211> 390
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 206
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln
            20                  25                  30          
Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu
        35                  40                  45              
Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu
    50                  55                  60                  
Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp
65                  70                  75                  80  
Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro
                85                  90                  95      
Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp
            100                 105                 110         
Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe
        115                 120                 125             
Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp
    130                 135                 140                 
Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu
145                 150                 155                 160 
Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr
                165                 170                 175     
Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe
            180                 185                 190         
Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala
        195                 200                 205             
Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser
    210                 215                 220                 
Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile
225                 230                 235                 240 
Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile
                245                 250                 255     
Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu
            260                 265                 270         
Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val
        275                 280                 285             
Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val
    290                 295                 300                 
Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu
305                 310                 315                 320 
Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu
                325                 330                 335     
Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly
            340                 345                 350         
Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
        355                 360                 365             
Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala
    370                 375                 380                 
Leu Phe Gln Lys Met Leu
385                 390 


<210> 207
<211> 390
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 207
Met Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe
 1               5                  10                  15      
Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu
            20                  25                  30          
Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg
        35                  40                  45              
Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys
    50                  55                  60                  
Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser
65                  70                  75                  80  
Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg
                85                  90                  95      
Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp
            100                 105                 110         
Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu
        115                 120                 125             
Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp
    130                 135                 140                 
Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp
145                 150                 155                 160 
Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu
                165                 170                 175     
Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu
            180                 185                 190         
Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro
        195                 200                 205             
Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val
    210                 215                 220                 
Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys
225                 230                 235                 240 
Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val
                245                 250                 255     
Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu
            260                 265                 270         
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser
        275                 280                 285             
Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala
    290                 295                 300                 
Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln
305                 310                 315                 320 
Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys
                325                 330                 335     
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
            340                 345                 350         
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
        355                 360                 365             
Met Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
    370                 375                 380                 
His His His His His His
385                 390 


<210> 208
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 208
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys
            20                  25                  30          
Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys
        35                  40                  45              
Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu
    50                  55                  60                  
Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser
65                  70                  75                  80  
Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln
                85                  90                  95      
Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu
            100                 105                 110         
Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg
        115                 120                 125             
Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro
    130                 135                 140                 
Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg
145                 150                 155                 160 
Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro
                165                 170                 175     
Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu
            180                 185                 190         
Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn
        195                 200                 205             
Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala
    210                 215                 220                 
Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala
225                 230                 235                 240 
Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln
                245                 250                 255     
Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln
            260                 265                 270         
Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala
        275                 280                 285             
Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg
    290                 295                 300                 
Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala
305                 310                 315                 320 
Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp
                325                 330                 335     
Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
            340                 345     


<210> 209
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 209
Met Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp
 1               5                  10                  15      
Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro
            20                  25                  30          
Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp
        35                  40                  45              
Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe
    50                  55                  60                  
Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp
65                  70                  75                  80  
Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu
                85                  90                  95      
Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr
            100                 105                 110         
Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe
        115                 120                 125             
Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala
    130                 135                 140                 
Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser
145                 150                 155                 160 
Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile
                165                 170                 175     
Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile
            180                 185                 190         
Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu
        195                 200                 205             
Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val
    210                 215                 220                 
Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val
225                 230                 235                 240 
Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu
                245                 250                 255     
Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu
            260                 265                 270         
Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly
        275                 280                 285             
Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
    290                 295                 300                 
Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala
305                 310                 315                 320 
Leu Phe Gln Lys Met Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                325                 330                 335     
Leu Asp Ser Thr His His His His His His
            340                 345     


<210> 210
<211> 359
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 210
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Gln Gly Arg Asp Ile Asn Leu Asp
            20                  25                  30          
Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn
        35                  40                  45              
Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser
    50                  55                  60                  
Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile
65                  70                  75                  80  
Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln
                85                  90                  95      
Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu
            100                 105                 110         
Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn
        115                 120                 125             
Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr
    130                 135                 140                 
Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val
145                 150                 155                 160 
Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro
                165                 170                 175     
Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp
            180                 185                 190         
Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr
        195                 200                 205             
Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg
    210                 215                 220                 
Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala
225                 230                 235                 240 
Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val
                245                 250                 255     
Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala
            260                 265                 270         
Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val
        275                 280                 285             
Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala
    290                 295                 300                 
Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr
305                 310                 315                 320 
Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu
                325                 330                 335     
Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu
            340                 345                 350         
Phe Gln Lys Met Leu Leu Glu
        355                 


<210> 211
<211> 359
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 211
Met Gly Ser Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile
 1               5                  10                  15      
Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe
            20                  25                  30          
Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln
        35                  40                  45              
Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu
    50                  55                  60                  
Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe
65                  70                  75                  80  
Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys
                85                  90                  95      
Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln
            100                 105                 110         
Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val
        115                 120                 125             
Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu
    130                 135                 140                 
Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys
145                 150                 155                 160 
Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu
                165                 170                 175     
Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg
            180                 185                 190         
Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe
        195                 200                 205             
Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser
    210                 215                 220                 
Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala
225                 230                 235                 240 
Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp
                245                 250                 255     
Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg
            260                 265                 270         
Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala
        275                 280                 285             
Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val
    290                 295                 300                 
Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu
305                 310                 315                 320 
Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met
                325                 330                 335     
Leu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
            340                 345                 350         
Thr His His His His His His
        355                 


<210> 212
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 212
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala
            20                  25                  30          
Phe Pro Ser Leu Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly
        35                  40                  45              
Glu Gly Pro Gly Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro
    50                  55                  60                  
Pro Pro Thr Ser Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu
65                  70                  75                  80  
Glu Gln Gly Pro Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala
                85                  90                  95      
Gln Leu Leu Trp Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala
            100                 105                 110         
Ala Val Leu Val Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile
        115                 120                 125             
Pro Ala Ala Cys Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser
    130                 135                 140                 
Ala Gln Asp Pro Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp
145                 150                 155                 160 
Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe
                165                 170                 175     
Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp
            180                 185                 190         
Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu
        195                 200                 205             
Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr
    210                 215                 220                 
Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe
225                 230                 235                 240 
Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala
                245                 250                 255     
Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser
            260                 265                 270         
Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile
        275                 280                 285             
Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile
    290                 295                 300                 
Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu
305                 310                 315                 320 
Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val
                325                 330                 335     
Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val
            340                 345                 350         
Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu
        355                 360                 365             
Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu
    370                 375                 380                 
Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly
385                 390                 395                 400 
Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
                405                 410                 415     
Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala
            420                 425                 430         
Leu Phe Gln Lys Met Leu
        435             


<210> 213
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 213
Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu
 1               5                  10                  15      
Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly
            20                  25                  30          
Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser
        35                  40                  45              
Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro
    50                  55                  60                  
Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp
65                  70                  75                  80  
Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val
                85                  90                  95      
Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys
            100                 105                 110         
Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro
        115                 120                 125             
Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg
    130                 135                 140                 
Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp
145                 150                 155                 160 
Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu
                165                 170                 175     
Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp
            180                 185                 190         
Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp
        195                 200                 205             
Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu
    210                 215                 220                 
Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu
225                 230                 235                 240 
Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro
                245                 250                 255     
Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val
            260                 265                 270         
Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys
        275                 280                 285             
Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val
    290                 295                 300                 
Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu
305                 310                 315                 320 
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser
                325                 330                 335     
Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala
            340                 345                 350         
Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln
        355                 360                 365             
Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys
    370                 375                 380                 
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
385                 390                 395                 400 
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
                405                 410                 415     
Met Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
            420                 425                 430         
His His His His His His
        435             


<210> 214
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 214
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Val Met Leu Gly Leu Lys Leu Thr Gly
            20                  25                  30          
Arg Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala
        35                  40                  45              
His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu
    50                  55                  60                  
Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu
65                  70                  75                  80  
Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln
                85                  90                  95      
Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu
            100                 105                 110         
Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu
        115                 120                 125             
Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp
    130                 135                 140                 
Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro
145                 150                 155                 160 
Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp
                165                 170                 175     
Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe
            180                 185                 190         
Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp
        195                 200                 205             
Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu
    210                 215                 220                 
Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr
225                 230                 235                 240 
Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe
                245                 250                 255     
Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala
            260                 265                 270         
Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser
        275                 280                 285             
Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile
    290                 295                 300                 
Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile
305                 310                 315                 320 
Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu
                325                 330                 335     
Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val
            340                 345                 350         
Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val
        355                 360                 365             
Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu
    370                 375                 380                 
Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu
385                 390                 395                 400 
Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly
                405                 410                 415     
Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys
            420                 425                 430         
Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala
        435                 440                 445             
Leu Phe Gln Lys Met Leu Leu Glu
    450                 455     


<210> 215
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 215
Met Gly Ser Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe
 1               5                  10                  15      
Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys
            20                  25                  30          
Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr
        35                  40                  45              
Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu
    50                  55                  60                  
Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe
65                  70                  75                  80  
Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu
                85                  90                  95      
Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg
            100                 105                 110         
Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys
        115                 120                 125             
Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser
    130                 135                 140                 
Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg
145                 150                 155                 160 
Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp
                165                 170                 175     
Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu
            180                 185                 190         
Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly Val Asp
        195                 200                 205             
Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp
    210                 215                 220                 
Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr Glu Glu
225                 230                 235                 240 
Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu
                245                 250                 255     
Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro
            260                 265                 270         
Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val
        275                 280                 285             
Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys
    290                 295                 300                 
Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val
305                 310                 315                 320 
Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu
                325                 330                 335     
Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser
            340                 345                 350         
Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala
        355                 360                 365             
Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln
    370                 375                 380                 
Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys
385                 390                 395                 400 
Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr
                405                 410                 415     
Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys
            420                 425                 430         
Met Leu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
        435                 440                 445             
Ser Thr His His His His His His
    450                 455     


<210> 216
<211> 460
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 216
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Arg Arg Arg Pro Gly Arg Arg Gln Pro Arg Ser
            20                  25                  30          
Ser Glu Cys Pro Leu Thr Arg Ser Val Ser Ser Lys Val Tyr Leu His
        35                  40                  45              
Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly
    50                  55                  60                  
Asn Val Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly
65                  70                  75                  80  
Leu His Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu
                85                  90                  95      
Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu
            100                 105                 110         
Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln
        115                 120                 125             
Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His
    130                 135                 140                 
Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu
145                 150                 155                 160 
Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu
                165                 170                 175     
Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg
            180                 185                 190         
Leu Ser Asn Gln Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr
        195                 200                 205             
Ala Gln Tyr Ser Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu
    210                 215                 220                 
Cys Leu Lys Pro Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys
225                 230                 235                 240 
Ala Arg Gln Thr Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu
                245                 250                 255     
Ser Pro Phe Met Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro
            260                 265                 270         
Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro
        275                 280                 285             
Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu
    290                 295                 300                 
Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp
305                 310                 315                 320 
Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp
                325                 330                 335     
Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala
            340                 345                 350         
Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala
        355                 360                 365             
Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His
    370                 375                 380                 
Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu
385                 390                 395                 400 
Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu
                405                 410                 415     
Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln
            420                 425                 430         
Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys
        435                 440                 445             
Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu
    450                 455                 460 


<210> 217
<211> 460
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 217
Met Arg Arg Arg Pro Gly Arg Arg Gln Pro Arg Ser Ser Glu Cys Pro
 1               5                  10                  15      
Leu Thr Arg Ser Val Ser Ser Lys Val Tyr Leu His Ala Ile Val Arg
            20                  25                  30          
Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp
        35                  40                  45              
Pro Leu Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln
    50                  55                  60                  
Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu
65                  70                  75                  80  
Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp
                85                  90                  95      
Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile
            100                 105                 110         
Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys
        115                 120                 125             
Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe
    130                 135                 140                 
Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp
145                 150                 155                 160 
Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln
                165                 170                 175     
Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser
            180                 185                 190         
Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro
        195                 200                 205             
Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr
    210                 215                 220                 
Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met
225                 230                 235                 240 
Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro
                245                 250                 255     
Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu
            260                 265                 270         
Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu
        275                 280                 285             
Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr
    290                 295                 300                 
Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly
305                 310                 315                 320 
Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala
                325                 330                 335     
Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys
            340                 345                 350         
Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln
        355                 360                 365             
Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg
    370                 375                 380                 
Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala
385                 390                 395                 400 
Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu
                405                 410                 415     
Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala
            420                 425                 430         
Ile Ala Leu Phe Gln Lys Met Leu Gly Lys Pro Ile Pro Asn Pro Leu
        435                 440                 445             
Leu Gly Leu Asp Ser Thr His His His His His His
    450                 455                 460 


<210> 218
<211> 506
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 218
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Arg Arg Arg Pro Gly Arg Arg Gln Pro
            20                  25                  30          
Arg Ser Ser Glu Cys Pro Leu Thr Arg Ser Val Ser Ser Lys Ser Glu
        35                  40                  45              
Asp Leu Ser Val Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp
    50                  55                  60                  
Ile Leu Phe Phe Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu
65                  70                  75                  80  
Thr Gly Arg Leu Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg
                85                  90                  95      
Asp Ala His Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp
            100                 105                 110         
Pro Leu Asp Val Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln
        115                 120                 125             
Leu Leu Asn Ser Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu
    130                 135                 140                 
Gly Gln Lys Ala Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp
145                 150                 155                 160 
Ala Leu Arg Phe Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile
                165                 170                 175     
Asn Leu Asp Val Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys
            180                 185                 190         
Leu Trp Asn Ala Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe
        195                 200                 205             
Val Pro Ser Pro Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp
    210                 215                 220                 
Arg Trp Ile Arg Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln
225                 230                 235                 240 
Gly Phe Gln Ala Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser
                245                 250                 255     
Phe Trp Leu Tyr Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro
            260                 265                 270         
Val Leu Asn Gly Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr
        275                 280                 285             
Leu Tyr Thr Cys Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met
    290                 295                 300                 
Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro
305                 310                 315                 320 
Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu
                325                 330                 335     
Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu
            340                 345                 350         
Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr
        355                 360                 365             
Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly
    370                 375                 380                 
Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala
385                 390                 395                 400 
Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys
                405                 410                 415     
Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln
            420                 425                 430         
Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg
        435                 440                 445             
Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala
    450                 455                 460                 
Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu
465                 470                 475                 480 
Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala
                485                 490                 495     
Ile Ala Leu Phe Gln Lys Met Leu Leu Glu
            500                 505     


<210> 219
<211> 506
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 219
Met Gly Ser Arg Arg Arg Pro Gly Arg Arg Gln Pro Arg Ser Ser Glu
 1               5                  10                  15      
Cys Pro Leu Thr Arg Ser Val Ser Ser Lys Ser Glu Asp Leu Ser Val
            20                  25                  30          
Phe Tyr Pro Gly Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe
        35                  40                  45              
Trp Val Ala Arg Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu
    50                  55                  60                  
Pro Phe Arg Glu Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly
65                  70                  75                  80  
Arg Lys Met Ser Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val
                85                  90                  95      
Ile Tyr Gly Ile Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser
            100                 105                 110         
Asn Leu Asp Pro Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala
        115                 120                 125             
Asp Phe Pro Ala Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe
    130                 135                 140                 
Gly Leu Cys Ala Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val
145                 150                 155                 160 
Asn Arg Ile Leu Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala
                165                 170                 175     
Thr Lys Phe Ala Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro
            180                 185                 190         
Thr Ser Gln Pro Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg
        195                 200                 205             
Ser Arg Leu Thr Glu Ala Val Arg Leu Ser Asn Gln Gly Phe Gln Ala
    210                 215                 220                 
Tyr Asp Phe Pro Ala Val Thr Thr Ala Gln Tyr Ser Phe Trp Leu Tyr
225                 230                 235                 240 
Glu Leu Cys Asp Val Tyr Leu Glu Cys Leu Lys Pro Val Leu Asn Gly
                245                 250                 255     
Val Asp Gln Val Ala Ala Glu Cys Ala Arg Gln Thr Leu Tyr Thr Cys
            260                 265                 270         
Leu Asp Val Gly Leu Arg Leu Leu Ser Pro Phe Met Pro Phe Val Thr
        275                 280                 285             
Glu Glu Leu Phe Gln Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro
    290                 295                 300                 
Ser Leu Cys Val Thr Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys
305                 310                 315                 320 
Asp Pro Glu Ala Glu Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg
                325                 330                 335     
Ala Val Arg Ser Leu Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro
            340                 345                 350         
Asp Cys Phe Leu Glu Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser
        355                 360                 365             
Ala Val Ser Gly Tyr Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala
    370                 375                 380                 
Val Leu Ala Leu Gly Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu
385                 390                 395                 400 
Ala Ser Asp Arg Cys Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp
                405                 410                 415     
Pro Ala Arg Glu Leu Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln
            420                 425                 430         
Arg Gln Ala Gln Arg Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro
        435                 440                 445             
Val Lys Val Pro Leu Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln
    450                 455                 460                 
Gln Thr Glu Ala Glu Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe
465                 470                 475                 480 
Gln Lys Met Leu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                485                 490                 495     
Leu Asp Ser Thr His His His His His His
            500                 505     


<210> 220
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 220
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Phe Val Thr Glu Glu Leu Phe Gln
            20                  25                  30          
Arg Leu Pro Arg Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr
        35                  40                  45              
Pro Tyr Pro Glu Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu
    50                  55                  60                  
Ala Ala Leu Glu Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu
65                  70                  75                  80  
Arg Ala Asp Tyr Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu
                85                  90                  95      
Val Ala Asp Glu Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr
            100                 105                 110         
Val Gln Ala Leu Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly
        115                 120                 125             
Ala Pro Ala Pro Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys
    130                 135                 140                 
Ser Ile His Leu Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu
145                 150                 155                 160 
Gly Lys Leu Gln Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg
                165                 170                 175     
Leu Arg Glu Arg Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu
            180                 185                 190         
Glu Val Gln Glu Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu
        195                 200                 205             
Leu Arg Lys Val Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu Leu
    210                 215                 220                 
Glu
225 


<210> 221
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> Valyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 221
Met Gly Ser Pro Phe Val Thr Glu Glu Leu Phe Gln Arg Leu Pro Arg
 1               5                  10                  15      
Arg Met Pro Gln Ala Pro Pro Ser Leu Cys Val Thr Pro Tyr Pro Glu
            20                  25                  30          
Pro Ser Glu Cys Ser Trp Lys Asp Pro Glu Ala Glu Ala Ala Leu Glu
        35                  40                  45              
Leu Ala Leu Ser Ile Thr Arg Ala Val Arg Ser Leu Arg Ala Asp Tyr
    50                  55                  60                  
Asn Leu Thr Arg Ile Arg Pro Asp Cys Phe Leu Glu Val Ala Asp Glu
65                  70                  75                  80  
Ala Thr Gly Ala Leu Ala Ser Ala Val Ser Gly Tyr Val Gln Ala Leu
                85                  90                  95      
Ala Ser Ala Gly Val Val Ala Val Leu Ala Leu Gly Ala Pro Ala Pro
            100                 105                 110         
Gln Gly Cys Ala Val Ala Leu Ala Ser Asp Arg Cys Ser Ile His Leu
        115                 120                 125             
Gln Leu Gln Gly Leu Val Asp Pro Ala Arg Glu Leu Gly Lys Leu Gln
    130                 135                 140                 
Ala Lys Arg Val Glu Ala Gln Arg Gln Ala Gln Arg Leu Arg Glu Arg
145                 150                 155                 160 
Arg Ala Ala Ser Gly Tyr Pro Val Lys Val Pro Leu Glu Val Gln Glu
                165                 170                 175     
Ala Asp Glu Ala Lys Leu Gln Gln Thr Glu Ala Glu Leu Arg Lys Val
            180                 185                 190         
Asp Glu Ala Ile Ala Leu Phe Gln Lys Met Leu Leu Glu Gly Lys Pro
        195                 200                 205             
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
    210                 215                 220                 
His
225 


<210> 222
<211> 1182
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 222
gacgtaatct acggcatcag cctgcaaggc ctgcacaacc aactgctgaa ttctaatctg 60
gatccgagcg aggtcgagaa agccaaagaa ggtcagaaag ctgattttcc ggcaggcatc 120
ccagaatgcg gtaccgatgc cctgcgcttc ggtctgtgcg cgtacatgtc tcaaggtcgt 180
gacattaatc tggacgttaa tcgtattttg ggttaccgtc atttttgcaa caagctgtgg 240
aacgcgacga agttcgcgct gcgtggtctg ggtaagggtt tcgttccaag cccgaccagc 300
cagccgggtg gccacgaatc cttggtcgat cgctggattc gcagccgtct gaccgaggcc 360
gtgcgtttga gcaaccaggg tttccaggca tacgatttcc ctgcggttac cactgcgcag 420
tatagctttt ggctgtatga gctgtgtgac gtgtatctgg aatgtctgaa gccggttctg 480
aatggtgtgg atcaggttgc ggcggagtgc gcacgccaga cgctgtacac ctgtctggat 540
gtcggtctgc gtttgctgtc gccgtttatg ccgtttgtga cggaagaact gtttcaacgc 600
ctgccgcgtc gcatgccaca agcacctccg agcctgtgtg tgacgccgta cccggagccg 660
agcgagtgct cctggaagga cccggaggcg gaagcggcgc tggagctggc gctgagcatt 720
acccgtgcgg tccgcagcct gcgtgcggac tataacttga cccgtatccg tccggactgc 780
ttcctggagg tcgcggacga agccacgggc gctctggcga gcgctgtcag cggctatgtg 840
caggccctgg catccgctgg cgttgttgcg gttctggcgc tgggtgcacc ggctccgcaa 900
ggttgcgcag ttgcactggc aagcgatcgt tgttctattc atttgcaatt gcagggcttg 960
gttgacccgg ctcgcgagct gggcaaactg caggcgaaac gtgtcgaggc ccagcgccaa 1020
gctcaacgtc tgcgcgaacg tcgtgcagcc agcggttacc cggtcaaagt gccgctggag 1080
gtgcaagaag cggacgaggc aaagctgcag caaaccgaag cggaattgcg taaagtggat 1140
gaggcgatcg ccctgttcca gaagatgctg taatgactcg ag                    1182

<210> 223
<211> 1119
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 223
ccgtccgaag tcgagaaagc aaaggaaggc cagaaagcag acttcccggc aggtattccg 60
gagtgtggca ccgacgcgct gcgttttggt ttgtgcgcgt acatgagcca gggccgtgac 120
atcaacctgg atgttaatcg tatcctgggc tatcgccact tctgtaacaa actgtggaat 180
gcgaccaagt tcgcgttgcg tggcctgggt aagggttttg tcccgagccc gacctcccaa 240
ccgggtggcc acgagagcct ggttgatcgc tggattcgtt ctcgtctgac tgaggcagtg 300
cgcctgtcta accagggttt tcaagcctat gattttccgg ccgtcacgac cgctcaatac 360
agcttttggc tgtatgagct gtgcgatgtc tatttggagt gcttgaagcc tgttctgaac 420
ggcgttgatc aagttgcggc agaatgcgct cgtcagacgc tgtacacctg tctggacgtc 480
ggcttgcgcc tgctgagccc gttcatgccg tttgttacgg aagagctgtt ccagcgcctg 540
ccgcgtcgta tgccgcaagc accgccgagc ctgtgcgtga ccccgtaccc ggagccgagc 600
gaatgtagct ggaaggatcc agaagcggaa gcagcgctgg agctggcact gtcgatcacg 660
cgtgctgtcc gctccctgcg tgcggactac aatctgacgc gcattcgccc ggactgcttc 720
ctggaagtgg cggatgaagc gaccggtgcc ctggcaagcg cggtaagcgg ttacgtgcag 780
gccttggcga gcgcgggtgt cgtcgcagtg ctggccctgg gtgccccagc gccgcagggc 840
tgcgcagttg ccctggctag cgaccgttgt agcattcatc tgcaactgca gggtctggtt 900
gaccctgcgc gcgaactggg taaattgcag gctaagcgtg tggaggccca acgtcaggcg 960
cagcgtctgc gtgagcgccg tgcggctagc ggttatccgg tgaaagtgcc actggaggtg 1020
caagaagcgg atgaggcgaa actgcaacag accgaagcgg agctgcgtaa agttgacgag 1080
gccatcgcgt tgttccaaaa gatgctgtaa tgactcgag                        1119

<210> 224
<211> 987
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 224
gtcaaccgca tcctgggcta ccgccacttc tgcaataaac tgtggaacgc cacgaaattt 60
gcgctgcgtg gtctgggcaa aggcttcgtg cctagcccga ccagccaacc gggtggccac 120
gagagcctgg tcgaccgctg gattcgcagc cgtctgaccg aggcagtacg tttgagcaat 180
cagggcttcc aagcctatga tttcccggca gtgacgacgg cgcaatattc tttctggctg 240
tatgagttgt gtgacgttta cctggaatgt ctgaagccgg tgttgaacgg tgtggatcaa 300
gttgcagcgg aatgtgcgcg ccagaccctg tacacgtgcc tggatgtcgg tctgcgtttg 360
ctgtccccgt ttatgccgtt cgttaccgaa gagttgtttc aacgtctgcc gcgtcgtatg 420
ccgcaggctc cgccgtcctt gtgcgttact ccgtacccgg aaccttcgga gtgtagctgg 480
aaagacccgg aggccgaagc tgcactggag ctggcactga gcatcacccg tgcggtgcgc 540
agcctgcgcg ctgattacaa tctgacccgc attcgtccgg attgctttct ggaggtcgcg 600
gacgaggcga ccggtgcgct ggcttctgca gtgagcggct atgtgcaagc actggcgagc 660
gcgggtgttg tcgcggtcct ggcgctgggt gctccggcac cgcaaggttg cgcggtcgcc 720
ctggcgtccg accgttgcag catccatctg cagttgcagg gtctggttga tccagcacgt 780
gagttgggta agctgcaggc caagcgtgtg gaggcgcaac gccaagcgca gcgtctgcgt 840
gaacgtcgtg cggccagcgg ctacccggtt aaggttccac tggaagtgca ggaagcagac 900
gaagccaaac tgcagcagac cgaagcggag ctgcgtaaag ttgacgaggc cattgcgctg 960
tttcagaaga tgctgtaatg actcgag                                     987

<210> 225
<211> 1014
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 225
ggatccagcc agggtcgtga cattaatctg gatgttaacc gtattctggg gtatcgccat 60
ttttgtaata aactgtggaa cgccaccaaa ttcgcactgc gtggtctggg taaaggtttt 120
gttccgagcc cgacttctca acctggtggt catgaaagcc tggtagaccg ttggattcgt 180
tctcgtctga ccgaagctgt tcgcctgtca aaccaaggat tccaagctta tgactttccg 240
gccgttacaa ctgctcagta ttccttctgg ctgtatgaac tgtgtgacgt gtatctggag 300
tgtctgaaac cggttctgaa tggcgtggat caggttgccg ccgaatgtgc tcgccaaacc 360
ctgtatacct gcctggacgt gggtctgcgt ctgctgtctc cgtttatgcc ttttgtgacc 420
gaggagctgt ttcaacgcct gcctcgtcgt atgccacaag ctccgccgag cctgtgtgtg 480
acaccttatc ctgagccgag tgaatgttcc tggaaagacc cagaggctga ggcagcactg 540
gaactggcac tgtctatcac acgtgctgtt cgttctctgc gcgctgacta taacctgact 600
cgtatccgtc ctgactgctt cctggaggtt gctgacgaag caaccggtgc cctggccagc 660
gctgttagtg gttatgtcca agctctggct agcgccggag tagtggctgt actggcactg 720
ggtgcccctg ccccacaggg gtgtgctgta gcactggcgt ctgaccgctg ttctatccac 780
ctgcaactgc aaggactggt cgacccagcc cgtgagctgg ggaaactgca agcaaaacgt 840
gtcgaggctc aacgccaagc acagcgtctg cgcgaacgcc gtgccgcttc tggctatcct 900
gttaaagtcc cactggaagt ccaagaggcg gatgaggcta aactgcaaca gactgaggct 960
gaactgcgca aagttgacga agccattgcc ctgtttcaaa aaatgctgct cgag       1014

<210> 226
<211> 1263
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 226
agcaccctgt acgtaagccc gcacccagac gcattcccga gcctgcgcgc gttgattgct 60
gcgcgctatg gcgaggcggg tgaaggtccg ggttggggtg gtgctcatcc gcgtatctgt 120
ctgcagccgc ctccgaccag ccgcacgccg ttcccgccac cgcgcctgcc ggctttggaa 180
cagggtccgg gtggtctgtg ggtctggggt gcgactgcgg tggcccaact gctgtggccg 240
gctggcctgg gtggtccagg tggcagccgt gcggcggtgc tggtccaaca atgggttagc 300
tatgcggaca ccgagctgat cccggctgca tgcggtgcga cgctgccggc attgggcctg 360
cgctcgtctg cccaagatcc gcagccgggt ggccacgaga gcctggttga ccgttggatt 420
cgtagccgtc tgaccgaagc agtgcgtctg tccaaccagg gcttccaggc gtacgacttt 480
ccggcggtca ccacggcgca atatagcttc tggctgtatg agttgtgtga tgtgtacctg 540
gagtgtctga agccggtgct gaacggtgtg gatcaagtcg cagccgaatg tgcccgtcaa 600
acgctgtata cctgcctgga cgtgggcctg cgtctgctga gcccgttcat gccgtttgtt 660
acggaagaat tgttccagcg cctgccgcgt cgtatgccgc aggcgcctcc gagcctgtgt 720
gttaccccgt acccggaacc gagcgagtgc agctggaaag acccggaggc tgaggccgcg 780
ttggaattgg cgctgtccat tacccgtgcg gtccgttctc tgcgtgcgga ttacaatctg 840
acccgcatcc gcccagattg ctttctggag gttgcggatg aagcaacggg tgcgctggca 900
tccgcagtct ctggttacgt tcaagcgctg gcgagcgccg gtgttgtagc agttctggca 960
ctgggcgctc cggcaccgca gggctgcgcg gtggccctgg cgagcgaccg ttgcagcatc 1020
catttgcagc tgcagggcct ggtcgaccct gcacgcgagt tgggcaagct gcaggcgaaa 1080
cgtgttgagg cccaacgtca agcacaacgt ttgcgtgagc gccgtgctgc aagcggctac 1140
ccggtgaagg ttccgctgga agtccaagaa gcagatgaag ccaaactgca gcagaccgag 1200
gcggagctgc gcaaagtgga cgaggcgatt gccctgtttc agaagatgct gtaatgactc 1260
gag                                                               1263

<210> 227
<211> 1305
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 227
ggatccgtga tgctgggtct gaaactgaca ggtcgtctgc cgttccgtga agtgtatctg 60
catgccattg tccgtgatgc tcatggtcgt aaaatgtcca aaagcctggg caacgtgatt 120
gatcctctgg atgtgatcta tgggatttcc ctgcaaggac tgcacaacca actgctgaat 180
agcaacctgg acccgtctga agttgaaaaa gccaaagagg gccagaaagc cgattttcca 240
gcgggtattc cggaatgtgg tacagatgct ctgcgtttcg gtctgtgtgc ctatatgtct 300
caagggcgtg atattaatct ggacgtcaac cgtatcctgg gttatcgtca cttctgtaac 360
aaactgtgga atgccaccaa atttgcactg cgtggtctgg gtaaaggttt tgtcccgagt 420
ccgacatctc agccaggggg gcacgaaagt ctggtcgatc gttggattcg tagtcgcctg 480
acggaggctg ttcgcctgag taatcagggt ttccaagcct atgacttccc tgctgtgaca 540
actgctcagt attccttctg gctgtatgaa ctgtgtgacg tttatctgga gtgcctgaaa 600
cctgttctga atggcgttga tcaggtggct gctgagtgtg ctcgtcaaac gctgtatacc 660
tgcctggacg ttggtctgcg tctgctgtca ccgtttatgc cgtttgtgac cgaggaactg 720
ttccagcgtc tgccacgtcg tatgcctcaa gcacctcctt ctctgtgtgt aacaccgtat 780
cctgaaccga gcgaatgttc gtggaaagat ccggaggcag aagcggcact ggagctggca 840
ctgtctatta cacgtgccgt acgctcgctg cgcgccgact ataatctgac ccgtattcgt 900
cctgactgct tcctggaagt ggccgatgaa gcaactggag cactggcatc agctgttagc 960
ggatatgttc aagcgctggc aagtgctggt gttgttgctg tactggctct gggagccccg 1020
gcaccacaag gctgtgctgt agcgctggct agtgatcgtt gtagcatcca tctgcagctg 1080
caaggtctgg ttgatcctgc tcgtgaactg ggcaaactgc aggccaaacg tgttgaagca 1140
caacgtcaag cccaacgcct gcgtgaacgt cgtgccgcct caggttatcc ggttaaagtt 1200
ccactggaag ttcaagaagc ggacgaggca aaactgcaac agactgaagc agaactgcgt 1260
aaagtggatg aggctattgc tctgtttcaa aaaatgctgc tcgag                 1305

<210> 228
<211> 1329
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 228
cgccgtcgcc caggtcgccg ccaaccacgc tcgtccgaat gcccgctgac ccgctccgta 60
agctctaagg tgtatttgca cgcgatcgtg cgtgatgccc acggtcgcaa aatgtccaag 120
agcttgggta acgtgattga cccgctggac gttatctacg gcatttctct gcagggcctg 180
cacaatcaac tgctgaacag caatctggat ccgagcgagg ttgaaaaggc aaaagagggt 240
cagaaggcgg atttcccggc tggtatcccg gagtgcggta cggacgcgtt gcgttttggc 300
ctgtgtgcgt atatgagcca gggtcgcgac atcaatctgg atgtcaaccg tattctgggc 360
taccgtcatt tttgcaacaa actgtggaat gcaacgaagt ttgcgctgcg tggcctgggt 420
aaaggctttg tcccgagccc gaccagccaa ccgggtggtc acgaaagctt ggtcgaccgt 480
tggatccgca gccgcttgac cgaagcggtt cgcctgagca accagggctt tcaagcgtat 540
gacttcccgg cagtgactac cgcacagtat agcttctggc tgtatgaact gtgcgacgtc 600
tacttggagt gcctgaagcc agtcctgaac ggcgttgacc aggtcgcggc tgagtgtgca 660
cgtcagactc tgtacacctg cctggatgtg ggtctgcgcc tgctgagccc gttcatgcct 720
ttcgtcaccg aagagttgtt tcaacgtctg ccgcgtcgta tgccgcaagc tccgccgagc 780
ctgtgtgtta ccccgtaccc ggagccgtct gagtgtagct ggaaagaccc ggaggcggaa 840
gcggccctgg aactggccct gtcgatcacc cgtgccgttc gtagcctgcg tgcggattac 900
aatttgacgc gtattcgtcc ggattgtttc ctggaggtgg ccgatgaagc cacgggtgcg 960
ctggcgtccg cggtcagcgg ttacgtgcaa gcgctggcaa gcgcaggcgt ggttgcagtc 1020
ctggcactgg gtgctcctgc gccgcaaggt tgtgcggtgg ccctggccag cgaccgttgc 1080
agcattcatc tgcagttgca gggtctggtg gatccggcac gtgaactggg caaactgcag 1140
gcaaagcgtg tggaggctca acgtcaggcg caacgtctgc gtgaacgtcg tgctgcgagc 1200
ggctacccgg ttaaggttcc gctggaggtt caggaagcag acgaggcgaa actgcagcaa 1260
acggaggcgg agttgcgcaa agttgatgag gccattgcgc tgttccagaa aatgctgtaa 1320
tgactcgag                                                         1329

<210> 229
<211> 1455
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 229
ggatcccgcc gtcgtcctgg tcgtcgtcaa cctcgtagca gtgaatgccc actgactcgt 60
agtgttagca gcaaaagcga agatctgagc gtgttctatc cagggactct gctggagact 120
ggtcatgata tcctgttttt ctgggttgcc cgtatggtta tgctgggcct gaaactgact 180
ggacgcctgc ctttccgtga ggtttatctg cacgcaatcg ttcgtgacgc ccacgggcgt 240
aaaatgtcta aaagtctggg gaatgttatc gatcctctgg acgtgattta tggtattagt 300
ctgcaaggac tgcataatca actgctgaac tcgaatctgg acccgtctga ggtggagaaa 360
gccaaagaag gtcaaaaagc ggacttccct gccggtattc ctgagtgtgg tacggatgca 420
ctgcgctttg gtctgtgtgc ctatatgtct cagggccgtg acattaatct ggatgtgaac 480
cgtattctgg gctatcgtca tttctgtaac aaactgtgga atgccaccaa attcgccctg 540
cgcggactgg gtaaaggatt cgttccttct ccgacaagtc aaccgggtgg acacgaaagt 600
ctggtagacc gttggattcg ttctcgtctg actgaagcgg tccgtctgtc caatcaaggt 660
ttccaagcgt atgactttcc ggcggttaca accgctcaat attcattttg gctgtatgag 720
ctgtgtgatg tgtatctgga gtgtctgaaa ccggtactga acggggtgga ccaagttgcc 780
gccgaatgtg cccgccaaac actgtatacg tgtctggatg tggggctgcg cctgctgagt 840
ccgtttatgc catttgtgac ggaggagctg ttccagcgtc tgccacgtcg tatgccacaa 900
gctccgcctt ctctgtgtgt gaccccttat cctgaaccga gtgaatgctc gtggaaagac 960
ccggaagctg aagctgctct ggagctggct ctgtctatca cccgtgctgt tcgttctctg 1020
cgcgccgact ataatctgac tcgtatccgt ccggactgtt ttctggaggt cgctgacgaa 1080
gcgacaggtg ccctggcctc ggcagtgtcc ggctatgtcc aagcactggc ttcggctggt 1140
gttgtcgccg tactggctct gggcgctcct gctcctcaag gctgtgccgt tgctctggca 1200
agtgatcgct gctcaatcca tctgcaactg caaggactgg tcgacccggc tcgtgagctg 1260
ggtaaactgc aagcaaaacg tgtggaggct caacgtcaag cacaacgtct gcgcgagcgc 1320
cgtgctgcct ctggctatcc tgtgaaagtg cctctggagg tccaagaggc tgatgaagcc 1380
aaactgcaac aaaccgaggc tgaactgcgc aaagtggacg aggctatcgc cctgttccaa 1440
aaaatgctgc tcgag                                                  1455

<210> 230
<211> 612
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Valyl tRNA Synthetase
      polynucleotide

<400> 230
ggatccccgt tcgttacaga agaactgttt cagcgtctgc ctcgtcgtat gcctcaagca 60
cctccatcac tgtgtgttac cccgtatcca gaaccttcag aatgctcgtg gaaagatccg 120
gaagccgaag ctgccctgga gctggctctg tctattactc gtgccgtacg ctctctgcgt 180
gcagattata acctgactcg tattcgccct gattgcttcc tggaagtggc agatgaagcc 240
acaggagcac tggcatcagc agtgtcggga tatgttcagg ccctggcaag tgccggtgtt 300
gttgctgtac tggctctggg agcaccagcc cctcaaggat gtgccgttgc tctggcctct 360
gatcgttgct ctattcacct gcagctgcaa ggtctggttg atcctgctcg tgaactggga 420
aaactgcaag ccaaacgtgt tgaagcccag cgtcaagctc aacgtctgcg tgaacgtcgt 480
gctgctagcg gctatccagt caaagttccg ctggaagttc aagaagccga cgaagcgaaa 540
ctgcagcaaa ccgaagcaga actgcgtaaa gtggacgaag ccattgccct gttccagaaa 600
atgctgctcg ag                                                     612
