                         SEQUENCE LISTING

<110>  Allegheny-Singer Research Institute
       Kathju , Sandeep
       Latha, Satish
 
<120>  Compositions and Methods for Reduced Scarring in Healing Wounds 
       and for Treatment and Prevention of Fibrosis

<130>  1356041.04402

<150>  US 61/328,957
<151>  2010-04-28

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit CCT-eta siRNA sense sequence

<400>  1
gaacgauuca guaguggcut t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit CCT-eta siRNA antisense sequence

<400>  2
agccacuacu gaaucguuct t                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scramble Control CCT-eta siRNA sense sequence

<400>  3
gaacgauucg aaugcuggut t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scramble Control CCT-eta siRNA antisense sequence

<400>  4
accagcauuc gaaucguuct t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit alpha-SMA siRNA sense sequence

<400>  5
agagaaauug ugcuauguct t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit alpha-SMA siRNA antisense sequence

<400>  6
gacauagcac aauuucucut t                                                 21


<210>  7
<211>  1875
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  7
gaggcattgt ggggttgctg ggcggcccgc acacagagaa gagaggagga gtagcgggct       60

actgcataag cttccaagat gatgccaaca ccagttatcc tgttgaaaga ggggactgac      120

agctctcaag gcattcccca gcttgtgagt aacattagtg cctgccaggt gattgctgag      180

gctgtacgaa ccacgctggg ccctcgtggc atggacaaac ttatcgtaga tggccgaggc      240

aaagctacaa tttccaacga tggggccaca atcctgaaac tccttgatgt cgtccatcct      300

gcagcaaaga ctttagtgga catcgcaaaa tcccaggatg ctgaggttgg tgatggaacc      360

acctcagtga ccctgctggc tgcagagttc ctgaagcagg tgaaaccgta tgtggaggaa      420

gggctgcacc cccagatcat catccgtgct ttccgcacag ccacccagtt ggcagttaac      480

aagatcaaag agattgctgt gactgtgaag aagcaagata aagtggagca gaggaagctg      540

ctggagaagt gtgccatgac agcgctgagc tccaagctca tctcccagca gaaagccttc      600

tttgctaaga tggtggttga tgcagtgatg atgcttgatg acttgttgca gcttaaaatg      660

attggaatca agaaggtcca aggtggagcc ctagaggagt ctcagctggt agctggtgtt      720

gcgttcaaga agactttctc ttacgctggg tttgaaatgc aacccaaaaa gtacaataat      780

cctatgattg cccttttaaa tgttgagctt gagctgaagg ctgagaaaga taatgctgaa      840

atcagagtcc acacggttga ggattatcag gcgattgttg atgctgagtg gaacattctc      900

tatgacaagt tagagaagat ctaccattcg ggagccaaag tcatcttgtc caaactgccc      960

attggggacg tggccaccca gtactttgct gacagggaca tgttctgtgc cggccgagtg     1020

cctgaggagg atctgaagag gacgatgatg gcctgtggtg gctccatcca gaccagtgtg     1080

aatgctctgt caccagacgt gttgggccgc tgccaggtgt ttgaagagac ccagattgga     1140

ggcgagagat ataatttctt cactggctgc cccaaggcca agacttgcac cttcatcctc     1200

cgaggtggtg ctgagcagtt tatggaggag acggagcggt ccctgcatga tgccatcatg     1260

attgtcagga gggccattaa gaacgattca gtagtggctg gtggcggggc cattgagatg     1320

gagctttcca agtacctgcg agattactca aggactattc caggaaaaca gcagctgttg     1380

attggggcgt atgccaaggc cttggagatc atcccacgtc agctgtgtga caacgctggt     1440

ttcgatgcca caaacatcct caacaagctg cgggctcggc atgcccaggg cggcatgtgg     1500

tacggggtgg acatcaacaa cgaggacatt gccgacaact ttgaggcctt tgtgtgggag     1560

ccggcgatgg tgcgcatcaa cgccttgacg gcagcctcgg aggcagcatg ccttatcgtg     1620

tccgtagatg aaaccatcaa gaacccccgc tcgactgtgg atgcaccgcc agcagcaggc     1680

cgtggccgag gccgtggccg tccccattga ggggcaccct gtccatcgta tggctgctta     1740

cagggtccat ttgctgtccc cgccttggtt agttgctgtt acaaggaagg gatagtaatt     1800

ggcccaactt ctccctggat ggtatttaaa taaaagttaa cacttagagt taactttgta     1860

agttaaaaaa aaaaa                                                      1875


<210>  8
<211>  1337
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  8
ggcacgaggg agaagcccag cccagcactg tcaggaatcc cgtgaagcag ctgcagctat       60

gtgtgaggaa gaggacagca ccgcccttgt gtgtgacaat ggctccgggc tctgtaaggc      120

tggctttgcc ggagacgatg ctccaagagc tgttttccca tccattgtgg gacgtcccag      180

gcaccagggg gtgatggtgg gaatggggca aaaagacagc tacgtgggtg atgaagcgca      240

gagcaaaaga ggaatcctga ccttgaagta cccgatcgaa catggcatca tcaccaactg      300

ggacgacatg gaaaagatct ggcaccactc cttctacaat gagcttcgcg ttgcccctga      360

agaacatcca accctgttga ctgaggcacc gctgaacccc aaagccaacc gggagaaaat      420

gacccagatt atgtttgaga ctttcaatgt cccagccatg tacgtggcta ttcaggcggt      480

gctgtccctc tatgcctctg gacgtacaac tggcattgtg ctggactctg gagatggtgt      540

cacccacaac gtgcccatct atgagggcta tgccctgccc catgccatca tgcgtctgga      600

cctggcaggc cgagatctca ctgactacct catgaagatc ctgactgagc gtggctattc      660

cttcgtgact actgctgaac gtgagattgt ccgggacatc aaagagaaat tgtgctatgt      720

cgctctggac tttgaaaacg agatggccac tgctgcatcc tcctcctccc tcgagaagag      780

ctatgagctg cctgacgggc aggtgatcac catcgggaac gaacgcttcc gctgcccaga      840

gaccctgttc cagccctcct tcatcgggat ggaatctgct ggcatccatg aaaccaccta      900

caacagcatc atgaagtgtg acatcgacat caggaaggac ctctatgcta acaatgtgct      960

ctcagggggc accaccatgt accctggcat tgctgaccgt atgcagaagg aaatcacggc     1020

cctagctccc agcaccatga agatcaagat aattgcccct ccagagcgca aatactccgt     1080

ctggatcggc ggctccatcc tggcctctct gtccaccttt cagcagatgt ggatcagcaa     1140

acaggagtac gatgaagccg ggccctccat tgtccaccgc aaatgcttct aagtcacttc     1200

cctgctctgt ttctagccca caactgtgaa tgtgttgtgg aataatgcct tcaattcctt     1260

tccaagtcat gcctatccaa agctctgact cattacctat gtatttttta ataaatctga     1320

aatatgctac cagtcaa                                                    1337


<210>  9
<211>  543
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  9

Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser 
1               5                   10                  15      


Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile 
            20                  25                  30          


Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu 
        35                  40                  45              


Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr 
    50                  55                  60                  


Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val 
65                  70                  75                  80  


Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser 
                85                  90                  95      


Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val 
            100                 105                 110         


Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala 
        115                 120                 125             


Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys 
    130                 135                 140                 


Lys Gln Asp Lys Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met 
145                 150                 155                 160 


Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala 
                165                 170                 175     


Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu 
            180                 185                 190         


Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Glu Ser 
        195                 200                 205             


Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly 
    210                 215                 220                 


Phe Glu Met Gln Pro Lys Lys Tyr Asn Asn Pro Met Ile Ala Leu Leu 
225                 230                 235                 240 


Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg 
                245                 250                 255     


Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn 
            260                 265                 270         


Ile Leu Tyr Asp Lys Leu Glu Lys Ile Tyr His Ser Gly Ala Lys Val 
        275                 280                 285             


Ile Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala 
    290                 295                 300                 


Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys 
305                 310                 315                 320 


Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala 
                325                 330                 335     


Leu Ser Pro Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln 
            340                 345                 350         


Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys 
        355                 360                 365             


Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu 
    370                 375                 380                 


Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile 
385                 390                 395                 400 


Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu 
                405                 410                 415     


Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln 
            420                 425                 430         


Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln 
        435                 440                 445             


Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu 
    450                 455                 460                 


Arg Ala Arg His Ala Gln Gly Gly Met Trp Tyr Gly Val Asp Ile Asn 
465                 470                 475                 480 


Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala 
                485                 490                 495     


Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu 
            500                 505                 510         


Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp 
        515                 520                 525             


Ala Pro Pro Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His 
    530                 535                 540             


<210>  10
<211>  376
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  10

Met Cys Glu Glu Glu Asp Ser Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Ser Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp Ile 
        275                 280                 285             


Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly Thr 
    290                 295                 300                 


Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala 
305                 310                 315                 320 


Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg 
                325                 330                 335     


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr 
            340                 345                 350         


Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly Pro 
        355                 360                 365             


Ser Ile Val His Arg Lys Cys Phe 
    370                 375     


<210>  11
<211>  1336
<212>  DNA
<213>  Homo sapiens

<400>  11
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgg attctcagct ggtagctggt gttgcattca      180

agaagacttt ctcttacgct gggtttgaaa tgcaacccaa aaagtaccac aatcccaaga      240

ttgccctttt gaatgtcgag ctcgagttga aagctgagaa agacaatgct gagataagag      300

tccacacagt tgaggattat caggcaattg ttgatgctga gtggaacatt ctctatgaca      360

agttagagaa gatccatcat tctggagcca aagttgtctt gtccaaactc cccattgggg      420

atgtggccac ccagtacttt gctgacaggg acatgttctg tgctggccga gtacctgagg      480

aggatctgaa gaggacaatg atggcctgtg gaggctcaat ccagaccagt gtgaatgctc      540

tgtcagcaga tgtgctgggt cgatgccagg tgtttgaaga gacccagatt ggaggcgaga      600

ggtacaattt ttttactggc tgccccaagg ccaagacatg caccttcatt ctccgtggcg      660

gcgccgagca gtttatggag gagacagagc ggtccctgca tgatgccatc atgatcgtca      720

ggagggccat caagaatgat tcagtggtgg ctggtggcgg ggccattgag atggaactct      780

ccaagtacct gcgggattac tcaaggacta ttccaggaaa acagcagctg ttgattgggg      840

catatgccaa ggccttggag attatcccac gccagctgtg tgacaatgct ggctttgatg      900

ccacaaacat tctcaacaag ctgcgggctc ggcatgccca ggggggtaca tggtatggag      960

tagacatcaa caacgaggac attgctgaca actttgaagc tttcgtgtgg gagccagcta     1020

tggtgcggat caatgcgctg acagcagcct ctgaggctgc gtgcctgatc gtgtctgtag     1080

atgaaaccat caagaacccc cgctcgactg tggatgctcc cacagcagca ggccggggcc     1140

gtggtcgtgg ccgcccccac tgagaggcac cccacccatc acatggctgg ctggctgctg     1200

ggtgcactta ccctccttgg cttggttact tcattttaca aggaaggggt agtaattggc     1260

ccactctctt cttactggag gctatttaaa taaaatgtaa gacttcagat aactttgtaa     1320

attaaaaaaa aaaaaa                                                     1336


<210>  12
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  12
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgg tgggtgatgg caccacctca gtgaccttgc      180

tggctgcaga gtttctgaag caggtgaaac cctatgtgga ggaaggttta cacccccaga      240

tcatcattcg agctttccgc acagccaccc agctggcagt taacaagatc aaagagattg      300

ctgtgaccgt gaagaaggca gataaagtgg agcagaggaa gctgctggaa aagtgtgcca      360

tgaccgctct gagctccaag ctgatctccc agcagaaagc tttctttgct aagatggtgg      420

tggatgcagt gatgatgctc gatgatttgc tgcagcttaa aatgattgga atcaagaagg      480

tacagggtgg agccctcgag gattctcagc tggtagctgg tgttgcattc aagaagactt      540

tctcttacgc tgggtttgaa atgcaaccca aaaagtacca caatcccaag attgcccttt      600

tgaatgtcga gctcgagttg aaagctgaga aagacaatgc tgagataaga gtccacacag      660

ttgaggatta tcaggcaatt gttgatgctg agtggaacat tctctatgac aagttagaga      720

agatccatca ttctggagcc aaagttgtct tgtccaaact ccccattggg gatgtggcca      780

cccagtactt tgctgacagg gacatgttct gtgctggccg agtacctgag gaggatctga      840

agaggacaat gatggcctgt ggaggctcaa tccagaccag tgtgaatgct ctgtcagcag      900

atgtgctggg tcgatgccag gtgtttgaag agacccagat tggaggcgag aggtacaatt      960

tttttactgg ctgccccaag gccaagacat gcaccttcat tctccgtggc ggcgccgagc     1020

agtttatgga ggagacagag cggtccctgc atgatgccat catgatcgtc aggagggcca     1080

tcaagaatga ttcagtggtg gctggtggcg gggccattga gatggaactc tccaagtacc     1140

tgcgggatta ctcaaggact attccaggaa aacagcagct gttgattggg gcatatgcca     1200

aggccttgga gattatccca cgccagctgt gtgacaatgc tggctttgat gccacaaaca     1260

ttctcaacaa gctgcgggct cggcatgccc aggggggtac atggtatgga gtagacatca     1320

acaacgagga cattgctgac aactttgaag ctttcgtgtg ggagccagct atggtgcgga     1380

tcaatgcgct gacagcagcc tctgaggctg cgtgcctgat cgtgtctgta gatgaaacca     1440

tcaagaaccc ccgctcgact gtggatgctc ccacagcagc aggccggggc cgtggtcgtg     1500

gccgccccca ctgagaggca ccccacccat cacatggctg gctggctgct gggtgcactt     1560

accctccttg gcttggttac ttcattttac aaggaagggg tagtaattgg cccactctct     1620

tcttactgga ggctatttaa ataaaatgta agacttcaga taactttgta aattaaaaaa     1680

aaaaaaa                                                               1687


<210>  13
<211>  2044
<212>  DNA
<213>  Homo sapiens

<400>  13
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgc attgctcatt cttgaagtcg tcttcatctt      180

ctgtgcagag gcagcatagt acagcagttg agagtaaggc ctctggagct acactgaatg      240

cctagcccac accagttatc ctattgaaag aggggactga tagctcccaa ggcatccccc      300

agcttgtgag taacatcagt gcctgccagg tgattgctga ggctgtaaga actaccctgg      360

gtccccgtgg catggacaag cttattgtag atggcagagg caaagcaaca atttctaatg      420

atggggccac aattctgaaa cttcttgatg ttgtccatcc tgcagcaaag actttggtag      480

acattgccaa atcccaagat gctgaggtgg gtgatggcac cacctcagtg accttgctgg      540

ctgcagagtt tctgaagcag gtgaaaccct atgtggagga aggtttacac ccccagatca      600

tcattcgagc tttccgcaca gccacccagc tggcagttaa caagatcaaa gagattgctg      660

tgaccgtgaa gaaggcagat aaagtggagc agaggaagct gctggaaaag tgtgccatga      720

ccgctctgag ctccaagctg atctcccagc agaaagcttt ctttgctaag atggtggtgg      780

atgcagtgat gatgctcgat gatttgctgc agcttaaaat gattggaatc aagaaggtac      840

agggtggagc cctcgaggat tctcagctgg tagctggtgt tgcattcaag aagactttct      900

cttacgctgg gtttgaaatg caacccaaaa agtaccacaa tcccaagatt gcccttttga      960

atgtcgagct cgagttgaaa gctgagaaag acaatgctga gataagagtc cacacagttg     1020

aggattatca ggcaattgtt gatgctgagt ggaacattct ctatgacaag ttagagaaga     1080

tccatcattc tggagccaaa gttgtcttgt ccaaactccc cattggggat gtggccaccc     1140

agtactttgc tgacagggac atgttctgtg ctggccgagt acctgaggag gatctgaaga     1200

ggacaatgat ggcctgtgga ggctcaatcc agaccagtgt gaatgctctg tcagcagatg     1260

tgctgggtcg atgccaggtg tttgaagaga cccagattgg aggcgagagg tacaattttt     1320

ttactggctg ccccaaggcc aagacatgca ccttcattct ccgtggcggc gccgagcagt     1380

ttatggagga gacagagcgg tccctgcatg atgccatcat gatcgtcagg agggccatca     1440

agaatgattc agtggtggct ggtggcgggg ccattgagat ggaactctcc aagtacctgc     1500

gggattactc aaggactatt ccaggaaaac agcagctgtt gattggggca tatgccaagg     1560

ccttggagat tatcccacgc cagctgtgtg acaatgctgg ctttgatgcc acaaacattc     1620

tcaacaagct gcgggctcgg catgcccagg ggggtacatg gtatggagta gacatcaaca     1680

acgaggacat tgctgacaac tttgaagctt tcgtgtggga gccagctatg gtgcggatca     1740

atgcgctgac agcagcctct gaggctgcgt gcctgatcgt gtctgtagat gaaaccatca     1800

agaacccccg ctcgactgtg gatgctccca cagcagcagg ccggggccgt ggtcgtggcc     1860

gcccccactg agaggcaccc cacccatcac atggctggct ggctgctggg tgcacttacc     1920

ctccttggct tggttacttc attttacaag gaaggggtag taattggccc actctcttct     1980

tactggaggc tatttaaata aaatgtaaga cttcagataa ctttgtaaat taaaaaaaaa     2040

aaaa                                                                  2044


<210>  14
<211>  1948
<212>  DNA
<213>  Homo sapiens

<400>  14
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgc ccacaccagt tatcctattg aaagagggga      180

ctgatagctc ccaaggcatc ccccagcttg tgagtaacat cagtgcctgc caggtgattg      240

ctgaggctgt aagaactacc ctgggtcccc gtggcatgga caagcttatt gtagatggca      300

gaggcaaagc aacaatttct aatgatgggg ccacaattct gaaacttctt gatgttgtcc      360

atcctgcagc aaagactttg gtagacattg ccaaatccca agatgctgag gtgggtgatg      420

gcaccacctc agtgaccttg ctggctgcag agtttctgaa gcaggtgaaa ccctatgtgg      480

aggaaggttt acacccccag atcatcattc gagctttccg cacagccacc cagctggcag      540

ttaacaagat caaagagatt gctgtgaccg tgaagaaggc agataaagtg gagcagagga      600

agctgctgga aaagtgtgcc atgaccgctc tgagctccaa gctgatctcc cagcagaaag      660

ctttctttgc taagatggtg gtggatgcag tgatgatgct cgatgatttg ctgcagctta      720

aaatgattgg aatcaagaag gtacagggtg gagccctcga ggattctcag ctggtagctg      780

gtgttgcatt caagaagact ttctcttacg ctgggtttga aatgcaaccc aaaaagtacc      840

acaatcccaa gattgccctt ttgaatgtcg agctcgagtt gaaagctgag aaagacaatg      900

ctgagataag agtccacaca gttgaggatt atcaggcaat tgttgatgct gagtggaaca      960

ttctctatga caagttagag aagatccatc attctggagc caaagttgtc ttgtccaaac     1020

tccccattgg ggatgtggcc acccagtact ttgctgacag ggacatgttc tgtgctggcc     1080

gagtacctga ggaggatctg aagaggacaa tgatggcctg tggaggctca atccagacca     1140

gtgtgaatgc tctgtcagca gatgtgctgg gtcgatgcca ggtgtttgaa gagacccaga     1200

ttggaggcga gaggtacaat ttttttactg gctgccccaa ggccaagaca tgcaccttca     1260

ttctccgtgg cggcgccgag cagtttatgg aggagacaga gcggtccctg catgatgcca     1320

tcatgatcgt caggagggcc atcaagaatg attcagtggt ggctggtggc ggggccattg     1380

agatggaact ctccaagtac ctgcgggatt actcaaggac tattccagga aaacagcagc     1440

tgttgattgg ggcatatgcc aaggccttgg agattatccc acgccagctg tgtgacaatg     1500

ctggctttga tgccacaaac attctcaaca agctgcgggc tcggcatgcc caggggggta     1560

catggtatgg agtagacatc aacaacgagg acattgctga caactttgaa gctttcgtgt     1620

gggagccagc tatggtgcgg atcaatgcgc tgacagcagc ctctgaggct gcgtgcctga     1680

tcgtgtctgt agatgaaacc atcaagaacc cccgctcgac tgtggatgct cccacagcag     1740

caggccgggg ccgtggtcgt ggccgccccc actgagaggc accccaccca tcacatggct     1800

ggctggctgc tgggtgcact taccctcctt ggcttggtta cttcatttta caaggaaggg     1860

gtagtaattg gcccactctc ttcttactgg aggctattta aataaaatgt aagacttcag     1920

ataactttgt aaattaaaaa aaaaaaaa                                        1948


<210>  15
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Met Asp Ser Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe 
1               5                   10                  15      


Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys 
            20                  25                  30          


Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn 
        35                  40                  45              


Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp 
    50                  55                  60                  


Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser 
65                  70                  75                  80  


Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr 
                85                  90                  95      


Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu 
            100                 105                 110         


Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr 
        115                 120                 125             


Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe 
    130                 135                 140                 


Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys 
145                 150                 155                 160 


Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln 
                165                 170                 175     


Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val 
            180                 185                 190         


Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile 
        195                 200                 205             


Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro 
    210                 215                 220                 


Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile 
225                 230                 235                 240 


Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile 
                245                 250                 255     


Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly 
            260                 265                 270         


Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val 
        275                 280                 285             


Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu 
    290                 295                 300                 


Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg 
305                 310                 315                 320 


Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly 
                325                 330                 335     


Arg Pro His 
            


<210>  16
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Met Val Gly Asp Gly Thr Thr Ser Val Thr Leu Leu Ala Ala Glu 
1               5                   10                  15      


Phe Leu Lys Gln Val Lys Pro Tyr Val Glu Glu Gly Leu His Pro Gln 
            20                  25                  30          


Ile Ile Ile Arg Ala Phe Arg Thr Ala Thr Gln Leu Ala Val Asn Lys 
        35                  40                  45              


Ile Lys Glu Ile Ala Val Thr Val Lys Lys Ala Asp Lys Val Glu Gln 
    50                  55                  60                  


Arg Lys Leu Leu Glu Lys Cys Ala Met Thr Ala Leu Ser Ser Lys Leu 
65                  70                  75                  80  


Ile Ser Gln Gln Lys Ala Phe Phe Ala Lys Met Val Val Asp Ala Val 
                85                  90                  95      


Met Met Leu Asp Asp Leu Leu Gln Leu Lys Met Ile Gly Ile Lys Lys 
            100                 105                 110         


Val Gln Gly Gly Ala Leu Glu Asp Ser Gln Leu Val Ala Gly Val Ala 
        115                 120                 125             


Phe Lys Lys Thr Phe Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys 
    130                 135                 140                 


Tyr His Asn Pro Lys Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Glu Lys Asp Asn Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr 
                165                 170                 175     


Gln Ala Ile Val Asp Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu 
            180                 185                 190         


Lys Ile His His Ser Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile 
        195                 200                 205             


Gly Asp Val Ala Thr Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala 
    210                 215                 220                 


Gly Arg Val Pro Glu Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly 
225                 230                 235                 240 


Gly Ser Ile Gln Thr Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly 
                245                 250                 255     


Arg Cys Gln Val Phe Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn 
            260                 265                 270         


Phe Phe Thr Gly Cys Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg 
        275                 280                 285             


Gly Gly Ala Glu Gln Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp 
    290                 295                 300                 


Ala Ile Met Ile Val Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala 
305                 310                 315                 320 


Gly Gly Gly Ala Ile Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr 
                325                 330                 335     


Ser Arg Thr Ile Pro Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala 
            340                 345                 350         


Lys Ala Leu Glu Ile Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe 
        355                 360                 365             


Asp Ala Thr Asn Ile Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly 
    370                 375                 380                 


Gly Thr Trp Tyr Gly Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn 
385                 390                 395                 400 


Phe Glu Ala Phe Val Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu 
                405                 410                 415     


Thr Ala Ala Ser Glu Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr 
            420                 425                 430         


Ile Lys Asn Pro Arg Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg 
        435                 440                 445             


Gly Arg Gly Arg Gly Arg Pro His 
    450                 455     


<210>  17
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Lys Leu Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn 
1               5                   10                  15      


Asp Gly Ala Thr Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala 
            20                  25                  30          


Lys Thr Leu Val Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp 
        35                  40                  45              


Gly Thr Thr Ser Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val 
    50                  55                  60                  


Lys Pro Tyr Val Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala 
65                  70                  75                  80  


Phe Arg Thr Ala Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala 
                85                  90                  95      


Val Thr Val Lys Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu 
            100                 105                 110         


Lys Cys Ala Met Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys 
        115                 120                 125             


Ala Phe Phe Ala Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp 
    130                 135                 140                 


Leu Leu Gln Leu Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala 
145                 150                 155                 160 


Leu Glu Asp Ser Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe 
                165                 170                 175     


Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys 
            180                 185                 190         


Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn 
        195                 200                 205             


Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp 
    210                 215                 220                 


Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser 
225                 230                 235                 240 


Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr 
                245                 250                 255     


Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu 
            260                 265                 270         


Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr 
        275                 280                 285             


Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe 
    290                 295                 300                 


Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys 
305                 310                 315                 320 


Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln 
                325                 330                 335     


Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val 
            340                 345                 350         


Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile 
        355                 360                 365             


Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro 
    370                 375                 380                 


Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile 
385                 390                 395                 400 


Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile 
                405                 410                 415     


Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly 
            420                 425                 430         


Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val 
        435                 440                 445             


Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu 
    450                 455                 460                 


Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg 
465                 470                 475                 480 


Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly 
                485                 490                 495     


Arg Pro His 
            


<210>  18
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser 
1               5                   10                  15      


Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile 
            20                  25                  30          


Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu 
        35                  40                  45              


Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr 
    50                  55                  60                  


Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val 
65                  70                  75                  80  


Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser 
                85                  90                  95      


Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val 
            100                 105                 110         


Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala 
        115                 120                 125             


Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys 
    130                 135                 140                 


Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met 
145                 150                 155                 160 


Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala 
                165                 170                 175     


Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu 
            180                 185                 190         


Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser 
        195                 200                 205             


Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly 
    210                 215                 220                 


Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu 
225                 230                 235                 240 


Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg 
                245                 250                 255     


Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn 
            260                 265                 270         


Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val 
        275                 280                 285             


Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala 
    290                 295                 300                 


Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys 
305                 310                 315                 320 


Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala 
                325                 330                 335     


Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln 
            340                 345                 350         


Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys 
        355                 360                 365             


Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu 
    370                 375                 380                 


Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile 
385                 390                 395                 400 


Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu 
                405                 410                 415     


Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln 
            420                 425                 430         


Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln 
        435                 440                 445             


Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu 
    450                 455                 460                 


Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn 
465                 470                 475                 480 


Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala 
                485                 490                 495     


Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu 
            500                 505                 510         


Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp 
        515                 520                 525             


Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His 
    530                 535                 540             


<210>  19
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Cys Glu Glu Glu Asp Ser Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Ser Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  20
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Cys Glu Glu Glu Asp Ser Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Ser Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  21
<211>  1798
<212>  DNA
<213>  Homo sapiens

<400>  21
ctctccccgc ccccgcgggg cggcgcgcac tcacccaccc gcgccggagc ggacctttgg       60

cttggcttgt cagggcttgt ccaggagttc cgctcctctc tccaaccggg gtccccctcc      120

agcgacccta aagcttccca gacttccgct tcaattcctg tccgcacccc acgcccacct      180

caacgtggag cgcagtggtc tccgaggagc gccggagctg ccccgcctgc ccagcggggt      240

cagcacttcg catcaaggcc caagaaaagc aagtcctcca gcgttctgag cacccgggcc      300

tgagggaagg tcctaacagc ccccgggagc cagtctccaa cgcctcccgc agcagcccgc      360

cgctcccagg tgcccgcgtg cgccgctgcc gccgcaatcc cgcacgcgtc ccgcgcccgc      420

cccactttgc ctatccccgg gactaagacg ggaatcctgt gaagcagctc cagctatgtg      480

tgaagaagag gacagcactg ccttggtgtg tgacaatggc tctgggctct gtaaggccgg      540

ctttgctggg gacgatgctc ccagggctgt tttcccatcc attgtgggac gtcccagaca      600

tcagggggtg atggtgggaa tgggacaaaa agacagctac gtgggtgacg aagcacagag      660

caaaagagga atcctgaccc tgaagtaccc gatagaacat ggcatcatca ccaactggga      720

cgacatggaa aagatctggc accactcttt ctacaatgag cttcgtgttg cccctgaaga      780

gcatcccacc ctgctcacgg aggcacccct gaaccccaag gccaaccggg agaaaatgac      840

tcaaattatg tttgagactt tcaatgtccc agccatgtat gtggctatcc aggcggtgct      900

gtctctctat gcctctggac gcacaactgg catcgtgctg gactctggag atggtgtcac      960

ccacaatgtc cccatctatg agggctatgc cttgccccat gccatcatgc gtctggatct     1020

ggctggccga gatctcactg actacctcat gaagatcctg actgagcgtg gctattcctt     1080

cgttactact gctgagcgtg agattgtccg ggacatcaag gagaaactgt gttatgtagc     1140

tctggacttt gaaaatgaga tggccactgc cgcatcctca tcctcccttg agaagagtta     1200

cgagttgcct gatgggcaag tgatcaccat cggaaatgaa cgtttccgct gcccagagac     1260

cctgttccag ccatccttca tcgggatgga gtctgctggc atccatgaaa ccacctacaa     1320

cagcatcatg aagtgtgata ttgacatcag gaaggacctc tatgctaaca atgtcctatc     1380

agggggcacc actatgtacc ctggcattgc cgaccgaatg cagaaggaga tcacggccct     1440

agcacccagc accatgaaga tcaagatcat tgcccctccg gagcgcaaat actctgtctg     1500

gatcggtggc tccatcctgg cctctctgtc caccttccag cagatgtgga tcagcaaaca     1560

ggaatacgat gaagccgggc cttccattgt ccaccgcaaa tgcttctaaa acactttcct     1620

gctcctctct gtctctagca cacaactgtg aatgtcctgt ggaattatgc cttcagttct     1680

tttccaaatc attcctagcc aaagctctga ctcgttacct atgtgttttt taataaatct     1740

gaaataggct actggtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1798


<210>  22
<211>  1415
<212>  DNA
<213>  Homo sapiens

<400>  22
gaggagagca ggccaagggg ctatataacc cttcagcttt cagcttccct gaacaccacc       60

cagtgtggag cagcccagcc aagcactgtc aggaatcctg tgaagcagct ccagctatgt      120

gtgaagaaga ggacagcact gccttggtgt gtgacaatgg ctctgggctc tgtaaggccg      180

gctttgctgg ggacgatgct cccagggctg ttttcccatc cattgtggga cgtcccagac      240

atcagggggt gatggtggga atgggacaaa aagacagcta cgtgggtgac gaagcacaga      300

gcaaaagagg aatcctgacc ctgaagtacc cgatagaaca tggcatcatc accaactggg      360

acgacatgga aaagatctgg caccactctt tctacaatga gcttcgtgtt gcccctgaag      420

agcatcccac cctgctcacg gaggcacccc tgaaccccaa ggccaaccgg gagaaaatga      480

ctcaaattat gtttgagact ttcaatgtcc cagccatgta tgtggctatc caggcggtgc      540

tgtctctcta tgcctctgga cgcacaactg gcatcgtgct ggactctgga gatggtgtca      600

cccacaatgt ccccatctat gagggctatg ccttgcccca tgccatcatg cgtctggatc      660

tggctggccg agatctcact gactacctca tgaagatcct gactgagcgt ggctattcct      720

tcgttactac tgctgagcgt gagattgtcc gggacatcaa ggagaaactg tgttatgtag      780

ctctggactt tgaaaatgag atggccactg ccgcatcctc atcctccctt gagaagagtt      840

acgagttgcc tgatgggcaa gtgatcacca tcggaaatga acgtttccgc tgcccagaga      900

ccctgttcca gccatccttc atcgggatgg agtctgctgg catccatgaa accacctaca      960

acagcatcat gaagtgtgat attgacatca ggaaggacct ctatgctaac aatgtcctat     1020

cagggggcac cactatgtac cctggcattg ccgaccgaat gcagaaggag atcacggccc     1080

tagcacccag caccatgaag atcaagatca ttgcccctcc ggagcgcaaa tactctgtct     1140

ggatcggtgg ctccatcctg gcctctctgt ccaccttcca gcagatgtgg atcagcaaac     1200

aggaatacga tgaagccggg ccttccattg tccaccgcaa atgcttctaa aacactttcc     1260

tgctcctctc tgtctctagc acacaactgt gaatgtcctg tggaattatg ccttcagttc     1320

ttttccaaat cattcctagc caaagctctg actcgttacc tatgtgtttt ttaataaatc     1380

tgaaataggc tactggtaaa aaaaaaaaaa aaaaa                                1415


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit CCT-beta sense 5' to 3'

<400>  23
ggagaaaguu gaacguauut t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit CCT-beta Antisense 5' to 3'

<400>  24
aauacguuca acuuucucct t                                                 21


<210>  25
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mETA-1203siF DNA insert

<400>  25
gatccaagaa tgactctgtg gtggctttca agagaagcca ccacagagtc attctt           56


<210>  26
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mETA-1203siR DNA insert

<400>  26
agcttaagaa tgactctgtg gtggcttctc ttgaaagcca ccacagagtc attctt           56


<210>  27
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEta-1205siF DNA insert

<400>  27
gatccgaatg actctgtggt ggctttcaag agaagccacc acagagtcat tctta            55


<210>  28
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEta-1205siR DNA insert

<400>  28
agcttaagaa tgactctgtg gtggcttctc ttgaaagcca ccacagagtc attcg            55


<210>  29
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Luciferase siRNA DNA insert

<400>  29
ggatcctcgc ttaccgattc agaatggttg atatccgcca ttctgaatcg gtaagcgacg       60

aagctt                                                                  66


