
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF THREONYL-tRNA SYNTHETASES
  

<130> 120161.483PC

<140> PCT                 
<141> 2011-04-27  

<150> US 61/328,369       
<151> 2010-04-27  

<150> US 61/328,371       
<151> 2010-04-27  

<150> US 61/328,373       
<151> 2010-04-27  

<160> 126

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 322
<212> PRT
<213> Homo sapiens

<400> 12
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly
            100                 105                 110         
Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp
        115                 120                 125             
Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe
    130                 135                 140                 
Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile
145                 150                 155                 160 
Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly
                165                 170                 175     
Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly
            180                 185                 190         
Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys
        195                 200                 205             
Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu
    210                 215                 220                 
Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu
225                 230                 235                 240 
Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro
                245                 250                 255     
Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile
            260                 265                 270         
Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys
        275                 280                 285             
Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp
    290                 295                 300                 
Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn
305                 310                 315                 320 
Arg Asp
        


<210> 13
<211> 966
<212> DNA
<213> Homo sapiens

<400> 13
atgtttgagg agaaggccag cagtccttca gggaagatgg gaggcgagga gaagccgatt 60
ggtgctggtg aagagaagca aaaggaagga ggcaaaaaga agaacaaaga aggatctgga 120
gatggaggtc gagctgagtt gaatccttgg cctgaatata tttacacacg tcttgagatg 180
tataatatac taaaagcaga acatgattcc attctggcag aaaaggcaga aaaagatagc 240
aagccaatta aagtcacttt gcctgatggt aaacaggttg atgcggaatc ttggaaaact 300
acaccatatc aaattgcctg tggaattagt caaggcctgg ccgacaacac cgttattgct 360
aaagtaaata atgttgtgtg ggacctggac cgccctctgg aagaagattg taccttggag 420
cttctcaagt ttgaggatga ggaagctcag gcagtgtatt ggcactctag tgctcacata 480
atgggtgaag ccatggaaag agtctatggt ggatgtttat gctacggtcc gccaatagaa 540
aatggattct attatgacat gtacctcgaa gaagggggtg tgtctagcaa tgatttctct 600
tctctggagg ctttgtgtaa gaaaatcatt aaagaaaaac aagcttttga aagactggaa 660
gttaagaaag aaactttact ggcaatgttt aagtacaaca agttcaaatg ccggatattg 720
aatgaaaagg tgaatactcc aactaccaca gtctatagat gtggcccttt gatagatctc 780
tgccggggtc ctcatgttag acacacgggc aaaattaagg ctttaaaaat acacaaaaat 840
tcctccacgt actgggaagg caaagcagat atggagactc tccagagaat ttatggcatt 900
tcattcccag atcctaaaat gttgaaagag tgggagaagt tccaagagga agctaaaaac 960
cgagat                                                            966

<210> 14
<211> 146
<212> PRT
<213> Homo sapiens

<400> 14
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly
            100                 105                 110         
Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp
        115                 120                 125             
Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe
    130                 135                 140                 
Glu Asp
145     


<210> 15
<211> 438
<212> DNA
<213> Homo sapiens

<400> 15
atgtttgagg agaaggccag cagtccttca gggaagatgg gaggcgagga gaagccgatt 60
ggtgctggtg aagagaagca aaaggaagga ggcaaaaaga agaacaaaga aggatctgga 120
gatggaggtc gagctgagtt gaatccttgg cctgaatata tttacacacg tcttgagatg 180
tataatatac taaaagcaga acatgattcc attctggcag aaaaggcaga aaaagatagc 240
aagccaatta aagtcacttt gcctgatggt aaacaggttg atgcggaatc ttggaaaact 300
acaccatatc aaattgcctg tggaattagt caaggcctgg ccgacaacac cgttattgct 360
aaagtaaata atgttgtgtg ggacctggac cgccctctgg aagaagattg taccttggag 420
cttctcaagt ttgaggat                                               438

<210> 16
<211> 17
<212> PRT
<213> Mus musculus

<400> 16
Met Ser Gln Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Asp Gly Glu
 1               5                  10                  15      
Lys
    


<210> 17
<211> 45
<212> PRT
<213> Mus musculus

<400> 17
Pro Val Asp Ala Ser Glu Glu Lys Arg Lys Glu Gly Gly Lys Lys Lys
 1               5                  10                  15      
Ser Lys Asp Gly Gly Gly Asp Gly Gly Arg Ala Glu Leu Asn Pro Trp
            20                  25                  30          
Pro Glu Tyr Ile Asn Thr Arg Leu Asp Met Tyr Asn Lys
        35                  40                  45  


<210> 18
<211> 12
<212> PRT
<213> Mus musculus

<400> 18
Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys
 1               5                  10          


<210> 19
<211> 74
<212> PRT
<213> Mus musculus

<400> 19
Met Ser Gln Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Asp Gly Glu
 1               5                  10                  15      
Lys Pro Val Asp Ala Ser Glu Glu Lys Arg Lys Glu Gly Gly Lys Lys
            20                  25                  30          
Lys Ser Lys Asp Gly Gly Gly Asp Gly Gly Arg Ala Glu Leu Asn Pro
        35                  40                  45              
Trp Pro Glu Tyr Ile Asn Thr Arg Leu Asp Met Tyr Asn Lys Leu Lys
    50                  55                  60                  
Ala Glu His Asp Ser Ile Leu Ala Glu Lys
65                  70                  
             


<210> 20
<211> 12
<212> PRT
<213> Mus musculus

<400> 20
Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys
 1               5                  10          


<210> 21
<211> 24
<212> PRT
<213> Mus musculus

<400> 21
Ala Ala Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys
 1               5                  10                  15      
Gln Val Asp Ala Glu Ser Trp Lys
            20                  


<210> 22
<211> 22
<212> PRT
<213> Mus musculus

<400> 22
Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly Leu Ala Asp
 1               5                  10                  15      
Asn Thr Val Val Ala Lys
            20          


<210> 23
<211> 58
<212> PRT
<213> Mus musculus

<400> 23
Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Ala Lys Asp
 1               5                  10                  15      
Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala
            20                  25                  30          
Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln
        35                  40                  45              
Gly Leu Ala Asp Asn Thr Val Val Ala Lys
    50                  55              


<210> 24
<211> 329
<212> PRT
<213> Homo sapiens

<400> 24
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly
            100                 105                 110         
Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp
        115                 120                 125             
Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe
    130                 135                 140                 
Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile
145                 150                 155                 160 
Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly
                165                 170                 175     
Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly
            180                 185                 190         
Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys
        195                 200                 205             
Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu
    210                 215                 220                 
Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu
225                 230                 235                 240 
Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro
                245                 250                 255     
Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile
            260                 265                 270         
Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys
        275                 280                 285             
Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp
    290                 295                 300                 
Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn
305                 310                 315                 320 
Arg Asp His Arg Lys Ile Gly Arg Pro
                325                 


<210> 25
<211> 990
<212> DNA
<213> Homo sapiens

<400> 25
atgtttgagg agaaggccag cagtccttca gggaagatgg gaggcgagga gaagccgatt 60
ggtgctggtg aagagaagca aaaggaagga ggcaaaaaga agaacaaaga aggatctgga 120
gatggaggtc gagctgagtt gaatccttgg cctgaatata tttacacacg tcttgagatg 180
tataatatac taaaagcaga acatgattcc attctggcag aaaaggcaga aaaagatagc 240
aagccaatta aagtcacttt gcctgatggt aaacaggttg atgcggaatc ttggaaaact 300
acaccatatc aaattgcctg tggaattagt caaggcctgg ccgacaacac cgttattgct 360
aaagtaaata atgttgtgtg ggacctggac cgccctctgg aagaagattg taccttggag 420
cttctcaagt ttgaggatga ggaagctcag gcagtgtatt ggcactctag tgctcacata 480
atgggtgaag ccatggaaag agtctatggt ggatgtttat gctacggtcc gccaatagaa 540
aatggattct attatgacat gtacctcgaa gaagggggtg tgtctagcaa tgatttctct 600
tctctggagg ctttgtgtaa gaaaatcatt aaagaaaaac aagcttttga aagactggaa 660
gttaagaaag aaactttact ggcaatgttt aagtacaaca agttcaaatg ccggatattg 720
aatgaaaagg tgaatactcc aactaccaca gtctatagat gtggcccttt gatagatctc 780
tgccggggtc ctcatgttag acacacgggc aaaattaagg ctttaaaaat acacaaaaat 840
tcctccacgt actgggaagg caaagcagat atggagactc tccagagaat ttatggcatt 900
tcattcccag atcctaaaat gttgaaagag tgggagaagt tccaagagga agctaaaaac 960
cgagatcata ggaaaattgg caggccatga                                  990

<210> 26
<211> 118
<212> PRT
<213> Homo sapiens

<400> 26
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Arg Cys Ile
            100                 105                 110         
Gly Thr Leu Val Leu Thr
        115             


<210> 27
<211> 357
<212> DNA
<213> Homo sapiens

<400> 27
atgtttgagg agaaggccag cagtccttca gggaagatgg gaggcgagga gaagccgatt 60
ggtgctggtg aagagaagca aaaggaagga ggcaaaaaga agaacaaaga aggatctgga 120
gatggaggtc gagctgagtt gaatccttgg cctgaatata tttacacacg tcttgagatg 180
tataatatac taaaagcaga acatgattcc attctggcag aaaaggcaga aaaagatagc 240
aagccaatta aagtcacttt gcctgatggt aaacaggttg atgcggaatc ttggaaaact 300
acaccatatc aaattgcctg tggaattagg tgtattggca ctctagtgct cacataa    357

<210> 28
<211> 688
<212> PRT
<213> Homo sapiens

<400> 28
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly
            100                 105                 110         
Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp
        115                 120                 125             
Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe
    130                 135                 140                 
Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile
145                 150                 155                 160 
Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly
                165                 170                 175     
Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly
            180                 185                 190         
Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys
        195                 200                 205             
Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu
    210                 215                 220                 
Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu
225                 230                 235                 240 
Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro
                245                 250                 255     
Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile
            260                 265                 270         
Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys
        275                 280                 285             
Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp
    290                 295                 300                 
Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn
305                 310                 315                 320 
Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His
                325                 330                 335     
Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile
            340                 345                 350         
Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly
        355                 360                 365             
Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met
    370                 375                 380                 
Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu
385                 390                 395                 400 
Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His
                405                 410                 415     
Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu
            420                 425                 430         
Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala
        435                 440                 445             
Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His
    450                 455                 460                 
Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu
465                 470                 475                 480 
Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu
                485                 490                 495     
Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp
            500                 505                 510         
Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu
        515                 520                 525             
Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile
    530                 535                 540                 
Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr
545                 550                 555                 560 
Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val
                565                 570                 575     
Arg Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly
            580                 585                 590         
Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp
        595                 600                 605             
Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn
    610                 615                 620                 
Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val
625                 630                 635                 640 
Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg
                645                 650                 655     
Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg
            660                 665                 670         
Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe
        675                 680                 685             


<210> 29
<211> 50
<212> DNA
<213> Homo sapiens

<400> 29
ccgagatcat aggaaaattg gcaggccatg atggtgatga taagaaaagg            50

<210> 30
<211> 9
<212> PRT
<213> Homo sapiens

<400> 30
Arg Asp His Arg Lys Ile Gly Arg Pro
 1               5                  


<210> 31
<211> 50
<212> DNA
<213> Homo sapiens

<400> 31
catatcaaat tgcctgtgga attaggtgta ttggcactct agtgctcaca            50

<210> 32
<211> 16
<212> PRT
<213> Homo sapiens

<400> 32
Tyr Gln Ile Ala Cys Gly Ile Arg Cys Ile Gly Thr Leu Val Leu Thr
 1               5                  10                  15      


<210> 33
<211> 50
<212> DNA
<213> Homo sapiens

<400> 33
tcagatttaa tcttacttat gtaaggccct tttggctgtc ccctcgccag            50

<210> 34
<211> 16
<212> PRT
<213> Homo sapiens

<400> 34
Arg Phe Asn Leu Thr Tyr Val Arg Pro Phe Trp Leu Ser Pro Arg Gln
 1               5                  10                  15      


<210> 35
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 35
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Phe Glu Glu Lys Ala Ser Ser Pro Ser
            20                  25                  30          
Gly Lys Met Gly Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys
        35                  40                  45              
Gln Lys Glu Gly Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly
    50                  55                  60                  
Gly Arg Ala Glu Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu
65                  70                  75                  80  
Glu Met Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu
                85                  90                  95      
Lys Ala Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly
            100                 105                 110         
Lys Gln Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala
        115                 120                 125             
Cys Gly Ile Ser Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val
    130                 135                 140                 
Asn Asn Val Val Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr
145                 150                 155                 160 
Leu Glu Leu Leu Lys Phe Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp
                165                 170                 175     
His Ser Ser Ala His Ile Met Gly Glu Ala Met Glu Arg Val Tyr Gly
            180                 185                 190         
Gly Cys Leu Cys Tyr Gly Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp
        195                 200                 205             
Met Tyr Leu Glu Glu Gly Gly Val Ser Ser Asn Asp Phe Ser Ser Leu
    210                 215                 220                 
Glu Ala Leu Cys Lys Lys Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg
225                 230                 235                 240 
Leu Glu Val Lys Lys Glu Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys
                245                 250                 255     
Phe Lys Cys Arg Ile Leu Asn Glu Lys Val Asn Thr Pro Thr Thr Thr
            260                 265                 270         
Val Tyr Arg Cys Gly Pro Leu Ile Asp Leu Cys Arg Gly Pro His Val
        275                 280                 285             
Arg His Thr Gly Lys Ile Lys Ala Leu Lys Ile His Lys Asn Ser Ser
    290                 295                 300                 
Thr Tyr Trp Glu Gly Lys Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr
305                 310                 315                 320 
Gly Ile Ser Phe Pro Asp Pro Lys Met Leu Lys Glu Trp Glu Lys Phe
                325                 330                 335     
Gln Glu Glu Ala Lys Asn Arg Asp Leu Glu
            340                 345     


<210> 36
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 36
Met Gly Ser Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly
 1               5                  10                  15      
Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly
            20                  25                  30          
Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu
        35                  40                  45              
Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn
    50                  55                  60                  
Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys
65                  70                  75                  80  
Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp
                85                  90                  95      
Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser
            100                 105                 110         
Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val
        115                 120                 125             
Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu
    130                 135                 140                 
Lys Phe Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala
145                 150                 155                 160 
His Ile Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys
                165                 170                 175     
Tyr Gly Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu
            180                 185                 190         
Glu Gly Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys
        195                 200                 205             
Lys Lys Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys
    210                 215                 220                 
Lys Glu Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg
225                 230                 235                 240 
Ile Leu Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys
                245                 250                 255     
Gly Pro Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly
            260                 265                 270         
Lys Ile Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu
        275                 280                 285             
Gly Lys Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe
    290                 295                 300                 
Pro Asp Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala
305                 310                 315                 320 
Lys Asn Arg Asp Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                325                 330                 335     
Leu Asp Ser Thr His His His His His His
            340                 345     


<210> 37
<211> 166
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis (DNA2.0) affinity tag

<400> 37
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys
            20                  25                  30          
Met Gly Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys
        35                  40                  45              
Glu Gly Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg
    50                  55                  60                  
Ala Glu Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met
65                  70                  75                  80  
Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala
                85                  90                  95      
Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln
            100                 105                 110         
Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly
        115                 120                 125             
Ile Ser Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn
    130                 135                 140                 
Val Val Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu
145                 150                 155                 160 
Leu Leu Lys Phe Glu Asp
                165     


<210> 38
<211> 166
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis (DNA2.0) affinity tag

<400> 38
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly
            100                 105                 110         
Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp
        115                 120                 125             
Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe
    130                 135                 140                 
Glu Asp Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
145                 150                 155                 160 
His His His His His His
                165     


<210> 39
<211> 349
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 39
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys
            20                  25                  30          
Met Gly Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys
        35                  40                  45              
Glu Gly Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg
    50                  55                  60                  
Ala Glu Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met
65                  70                  75                  80  
Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala
                85                  90                  95      
Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln
            100                 105                 110         
Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly
        115                 120                 125             
Ile Ser Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn
    130                 135                 140                 
Val Val Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu
145                 150                 155                 160 
Leu Leu Lys Phe Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser
                165                 170                 175     
Ser Ala His Ile Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys
            180                 185                 190         
Leu Cys Tyr Gly Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr
        195                 200                 205             
Leu Glu Glu Gly Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala
    210                 215                 220                 
Leu Cys Lys Lys Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu
225                 230                 235                 240 
Val Lys Lys Glu Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys
                245                 250                 255     
Cys Arg Ile Leu Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr
            260                 265                 270         
Arg Cys Gly Pro Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His
        275                 280                 285             
Thr Gly Lys Ile Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr
    290                 295                 300                 
Trp Glu Gly Lys Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile
305                 310                 315                 320 
Ser Phe Pro Asp Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu
                325                 330                 335     
Glu Ala Lys Asn Arg Asp His Arg Lys Ile Gly Arg Pro
            340                 345                 


<210> 40
<211> 349
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 40
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly Gly Lys
            20                  25                  30          
Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu Leu Asn
        35                  40                  45              
Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn Ile Leu
    50                  55                  60                  
Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys Asp Ser
65                  70                  75                  80  
Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp Ala Glu
                85                  90                  95      
Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser Gln Gly
            100                 105                 110         
Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val Trp Asp
        115                 120                 125             
Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu Lys Phe
    130                 135                 140                 
Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile
145                 150                 155                 160 
Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly
                165                 170                 175     
Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly
            180                 185                 190         
Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys
        195                 200                 205             
Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu
    210                 215                 220                 
Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu
225                 230                 235                 240 
Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro
                245                 250                 255     
Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile
            260                 265                 270         
Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys
        275                 280                 285             
Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp
    290                 295                 300                 
Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn
305                 310                 315                 320 
Arg Asp His Arg Lys Ile Gly Arg Pro Gly Lys Pro Ile Pro Asn Pro
                325                 330                 335     
Leu Leu Gly Leu Asp Ser Thr His His His His His His
            340                 345                 


<210> 41
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 41
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Phe Glu Glu Lys Ala Ser Ser Pro Ser
            20                  25                  30          
Gly Lys Met Gly Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys
        35                  40                  45              
Gln Lys Glu Gly Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly
    50                  55                  60                  
Gly Arg Ala Glu Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu
65                  70                  75                  80  
Glu Met Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu
                85                  90                  95      
Lys Ala Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly
            100                 105                 110         
Lys Gln Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala
        115                 120                 125             
Cys Gly Ile Arg Cys Ile Gly Thr Leu Val Leu Thr Leu Glu
    130                 135                 140         


<210> 42
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 42
Met Gly Ser Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly
 1               5                  10                  15      
Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly
            20                  25                  30          
Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu
        35                  40                  45              
Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn
    50                  55                  60                  
Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys
65                  70                  75                  80  
Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp
                85                  90                  95      
Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Arg
            100                 105                 110         
Cys Ile Gly Thr Leu Val Leu Thr Leu Glu Gly Lys Pro Ile Pro Asn
        115                 120                 125             
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
    130                 135                 140         


<210> 43
<211> 170
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis (Genewiz) affinity tag

<400> 43
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Phe Glu Glu Lys Ala Ser Ser Pro Ser
            20                  25                  30          
Gly Lys Met Gly Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys
        35                  40                  45              
Gln Lys Glu Gly Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly
    50                  55                  60                  
Gly Arg Ala Glu Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu
65                  70                  75                  80  
Glu Met Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu
                85                  90                  95      
Lys Ala Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly
            100                 105                 110         
Lys Gln Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala
        115                 120                 125             
Cys Gly Ile Ser Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val
    130                 135                 140                 
Asn Asn Val Val Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr
145                 150                 155                 160 
Leu Glu Leu Leu Lys Phe Glu Asp Leu Glu
                165                 170 


<210> 44
<211> 170
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis (Genewiz) affinity tag

<400> 44
Met Gly Ser Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly
 1               5                  10                  15      
Gly Glu Glu Lys Pro Ile Gly Ala Gly Glu Glu Lys Gln Lys Glu Gly
            20                  25                  30          
Gly Lys Lys Lys Asn Lys Glu Gly Ser Gly Asp Gly Gly Arg Ala Glu
        35                  40                  45              
Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu Met Tyr Asn
    50                  55                  60                  
Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys Ala Glu Lys
65                  70                  75                  80  
Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys Gln Val Asp
                85                  90                  95      
Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys Gly Ile Ser
            100                 105                 110         
Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn Asn Val Val
        115                 120                 125             
Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu Glu Leu Leu
    130                 135                 140                 
Lys Phe Glu Asp Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
145                 150                 155                 160 
Leu Asp Ser Thr His His His His His His
                165                 170 


<210> 45
<211> 975
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Threonyl tRNA synthetase
      polynucleotide

<400> 45
ggatccttcg aagaaaaagc gagcagccct agcggtaaaa tgggtggcga agagaaacca 60
attggtgctg gcgaagagaa acagaaagaa ggcggtaaaa aaaaaaacaa agagggcagc 120
ggcgacggcg gtcgtgctga actgaatcct tggccggagt atatctatac acgcctggag 180
atgtataaca tcctgaaagc cgagcatgat tctattctgg cggagaaagc agagaaagac 240
tccaaaccga ttaaagtgac cctgccggat ggaaaacaag ttgatgccga gtcctggaaa 300
acgacaccgt atcagattgc ctgtggtatc agtcaaggtc tggccgacaa taccgtgatt 360
gctaaagtga ataacgtggt gtgggatctg gaccgtcctc tggaggaaga ttgtaccctg 420
gagctgctga aatttgagga tgaggaagca caggccgttt attggcatag cagcgcccac 480
atcatgggag aagcaatgga acgtgtgtat ggtgggtgtc tgtgttatgg tccgccgatt 540
gaaaatggct tctattatga catgtatctg gaagagggtg gtgttagtag taacgacttt 600
tcgtcgctgg aagctctgtg taaaaaaatc atcaaagaga aacaagcctt tgaacgcctg 660
gaagtgaaaa aagaaaccct gctggcaatg ttcaaatata acaaattcaa atgccgtatc 720
ctgaacgaga aagtgaacac cccgaccaca actgtttatc gctgtggccc actgattgat 780
ctgtgccgtg gtccacacgt ccgtcatacc ggcaaaatca aagccctgaa aatccacaaa 840
aacagctcga cgtattggga aggcaaagcg gatatggaga ctctgcagcg catttatggc 900
atctcattcc cggacccaaa aatgctgaaa gagtgggaga aattccaaga agaggcgaaa 960
aaccgtgacc tcgag                                                  975

<210> 46
<211> 447
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized (DNA2.0) Threonyl tRNA synthetase
      polynucleotide

<400> 46
tttgaagaga aagccagctc tcctagcggt aagatgggtg gtgaagagaa gccgatcggt 60
gctggcgaag aaaagcagaa agaaggcggc aagaagaaaa acaaagaggg ttccggtgac 120
ggcggtcgtg cggaactgaa tccgtggccg gagtacattt acacccgtct ggagatgtat 180
aacatcctga aagcagaaca cgacagcatc ctggcagaga aggcggagaa ggacagcaaa 240
ccgatcaaag ttactctgcc ggacggcaag caagtggatg cagagagctg gaaaaccacc 300
ccgtatcaga ttgcgtgtgg tattagccaa ggcttggcgg ataacacggt gattgccaag 360
gtcaataatg tcgtttggga cctggatcgc ccactggaag aggattgcac gctggagctg 420
ttgaaattcg aggattaatg actcgag                                     447

<210> 47
<211> 996
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Threonyl tRNA synthetase
      polynucleotide

<400> 47
ttcgaagaga aagcaagctc tccaagcggt aagatgggcg gtgaagagaa gccgattggt 60
gctggcgaag agaagcaaaa agagggtggt aagaagaaga ataaagaggg cagcggcgat 120
ggtggccgtg cggaactgaa cccgtggccg gagtatatct acacccgtct ggagatgtac 180
aacattctga aagcggaaca tgacagcatt ctggcggaaa aggccgagaa agacagcaaa 240
ccgatcaaag ttaccctgcc ggatggtaag caggtggatg ccgaatcgtg gaaaacgacg 300
ccgtaccaga ttgcctgcgg catcagccaa ggtctggctg ataacacggt tatcgcgaag 360
gtcaacaatg tcgtgtggga cttggaccgc ccgttggaag aggactgcac cctggagctg 420
ctgaaattcg aggacgaaga agcgcaggcg gtctattggc acagcagcgc acacatcatg 480
ggtgaagcaa tggagcgcgt ctacggtggt tgcctgtgtt acggtccgcc gattgagaat 540
ggtttctact atgacatgta tctggaagaa ggcggcgttt ccagcaacga cttctctagc 600
ctggaggcgc tgtgtaagaa gattatcaaa gagaaacagg cgttcgagcg tttggaggtg 660
aagaaagaaa ctctgctggc gatgtttaag tacaacaagt ttaagtgccg tattctgaac 720
gagaaagtta atacgccgac caccaccgtt taccgttgtg gtccgttgat cgacctgtgc 780
cgtggtcctc acgtgcgcca taccggcaag atcaaggcac tgaaaattca caagaattcc 840
agcacctatt gggagggcaa ggccgatatg gaaacgctgc aacgcatcta tggtatcagc 900
tttccagatc cgaaaatgct gaaagaatgg gagaaatttc aagaagaggc gaaaaatcgt 960
gatcatcgca aaattggccg tccgtaatga ctcgag                           996

<210> 48
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Threonyl tRNA synthetase
      polynucleotide

<400> 48
ggatcctttg aggaaaaagc gtcaagccct tctggaaaaa tgggaggcga agagaaaccg 60
atcggagccg gcgaagagaa acagaaagag gggggcaaaa aaaaaaacaa agaaggctcg 120
ggcgacggag ggcgtgctga actgaaccca tggccggagt atatctatac ccgcctggaa 180
atgtataaca ttctgaaagc ggaacacgac agcattctgg ccgaaaaagc ggagaaagat 240
tccaaaccga tcaaagtcac actgcctgat ggcaaacagg tggacgccga aagctggaaa 300
accacgcctt atcaaatcgc ttgtggcatt cgctgtattg gtactctggt tctgacgctc 360
gag                                                               363

<210> 49
<211> 447
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized (Genewiz) Threonyl tRNA synthetase
      polynucleotide

<400> 49
ggatccttcg aagagaaagc ctcaagtccg agtggcaaaa tgggtggcga ggaaaaacca 60
atcggagccg gtgaagaaaa acagaaagag ggcggcaaaa aaaaaaacaa agaaggcagc 120
ggcgacggag gtcgtgctga actgaatcct tggccggagt atatctatac ccgcctggag 180
atgtataaca ttctgaaagc cgagcatgat tccattctgg ccgaaaaagc cgagaaagac 240
tcaaaaccga tcaaagtgac tctgccagat ggcaaacaag ttgatgccga atcttggaaa 300
acaacccctt atcagatcgc ctgtggtatc agtcagggac tggccgacaa tactgttatt 360
gccaaagtca acaacgttgt gtgggatctg gaccgtcctc tggaagaaga ttgtaccctg 420
gaactgctga aattcgagga tctcgag                                     447

<210> 50
<211> 417
<212> PRT
<213> Homo sapiens

<400> 50
Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp
 1               5                  10                  15      
His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu Leu
            20                  25                  30          
Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn
        35                  40                  45              
Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln
    50                  55                  60                  
Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser
65                  70                  75                  80  
Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu
                85                  90                  95      
Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu
            100                 105                 110         
Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu
        115                 120                 125             
Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr
    130                 135                 140                 
Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe
145                 150                 155                 160 
Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe
                165                 170                 175     
Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu
            180                 185                 190         
Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln
        195                 200                 205             
Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp
    210                 215                 220                 
Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile
225                 230                 235                 240 
Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln
                245                 250                 255     
Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His
            260                 265                 270         
Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu
        275                 280                 285             
Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly
    290                 295                 300                 
Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val
305                 310                 315                 320 
Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His
                325                 330                 335     
Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu
            340                 345                 350         
Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu
        355                 360                 365             
Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr
    370                 375                 380                 
Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu
385                 390                 395                 400 
Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu
                405                 410                 415     
Phe
    


<210> 51
<211> 1254
<212> DNA
<213> Homo sapiens

<400> 51
atgttgaaag agtgggagaa gttccaagag gaagctaaaa accgagatca taggaaaatt 60
ggcagggacc aagaactata tttctttcat gaactcagcc ctggaagttg cttttttctg 120
ccaaaaggag cctacattta taatgcactt attgaattca ttaggagcga atataggaaa 180
agaggattcc aggaggtagt caccccaaac atcttcaaca gccgactctg gatgacctcg 240
ggccactggc agcactacag cgagaacatg ttctcctttg aggtggagaa ggagctgttt 300
gccctgaaac ccatgaactg cccaggacac tgccttatgt ttgatcatcg gccaaggtcc 360
tggcgagaac tgcctctgcg gctagctgat tttggggtac ttcataggaa cgagctgtct 420
ggagcactca caggactcac ccgggtacga agattccaac aggatgatgc tcacatattc 480
tgtgccatgg agcagattga agatgaaata aaaggttgtt tggattttct acgtacggta 540
tatagcgtat ttggattttc ttttaaacta aacctttcta ctcgcccgga aaaattcctt 600
ggagatatcg aagtatggga tcaagctgag aaacaacttg aaaacagtct gaatgaattt 660
ggtgaaaagt gggagttaaa ctctggagat ggagctttct atggcccaaa gattgacata 720
cagattaaag atgcgattgg gcggtaccac cagtgtgcaa ccatccagct ggatttccag 780
ttgcccatca gatttaatct tacttatgta agccatgatg gtgatgataa gaaaaggcca 840
gtgattgttc atcgagccat cttgggatca gtggaaagaa tgattgctat cctcacagaa 900
aactatgggg gcaaatggcc cttttggctg tcccctcgcc aggtaatggt agttccagtg 960
ggaccaacct gtgatgaata tgcccaaaag gtacgacaac aattccacga tgccaaattc 1020
atggcagaca ttgatctgga tccaggctgt acattgaata aaaagattcg aaatgcacag 1080
ttagcacagt ataacttcat tttagttgtt ggtgaaaaag agaaaatcag tggcactgtt 1140
aatatccgca caagagacaa taaggtccac ggggaacgca ccatttctga aactatcgag 1200
cggctacagc agctcaaaga gttccgcagc aaacaggcag aagaagaatt ttaa       1254

<210> 52
<211> 378
<212> PRT
<213> Homo sapiens

<400> 52
Leu Pro Lys Gly Ala Tyr Ile Tyr Asn Ala Leu Ile Glu Phe Ile Arg
 1               5                  10                  15      
Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile
            20                  25                  30          
Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser
        35                  40                  45              
Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Leu Phe Ala Leu Lys
    50                  55                  60                  
Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg
65                  70                  75                  80  
Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His
                85                  90                  95      
Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg
            100                 105                 110         
Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu
        115                 120                 125             
Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val
    130                 135                 140                 
Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe
145                 150                 155                 160 
Leu Gly Asp Ile Glu Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn
                165                 170                 175     
Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly
            180                 185                 190         
Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly
        195                 200                 205             
Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile
    210                 215                 220                 
Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg
225                 230                 235                 240 
Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile
                245                 250                 255     
Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser
            260                 265                 270         
Pro Arg Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr
        275                 280                 285             
Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe Met Ala Asp
    290                 295                 300                 
Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala
305                 310                 315                 320 
Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu Lys Glu Lys
                325                 330                 335     
Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys Val His Gly
            340                 345                 350         
Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu
        355                 360                 365             
Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe
    370                 375             


<210> 53
<211> 1137
<212> DNA
<213> Homo sapiens

<400> 53
ctgccaaaag gagcctacat ttataatgca cttattgaat tcattaggag cgaatatagg 60
aaaagaggat tccaggaggt agtcacccca aacatcttca acagccgact ctggatgacc 120
tcgggccact ggcagcacta cagcgagaac atgttctcct ttgaggtgga gaaggagctg 180
tttgccctga aacccatgaa ctgcccagga cactgcctta tgtttgatca tcggccaagg 240
tcctggcgag aactgcctct gcggctagct gattttgggg tacttcatag gaacgagctg 300
tctggagcac tcacaggact cacccgggta cgaagattcc aacaggatga tgctcacata 360
ttctgtgcca tggagcagat tgaagatgaa ataaaaggtt gtttggattt tctacgtacg 420
gtatatagcg tatttggatt ttcttttaaa ctaaaccttt ctactcgccc ggaaaaattc 480
cttggagata tcgaagtatg ggatcaagct gagaaacaac ttgaaaacag tctgaatgaa 540
tttggtgaaa agtgggagtt aaactctgga gatggagctt tctatggccc aaagattgac 600
atacagatta aagatgcgat tgggcggtac caccagtgtg caaccatcca gctggatttc 660
cagttgccca tcagatttaa tcttacttat gtaagccatg atggtgatga taagaaaagg 720
ccagtgattg ttcatcgagc catcttggga tcagtggaaa gaatgattgc tatcctcaca 780
gaaaactatg ggggcaaatg gcccttttgg ctgtcccctc gccaggtaat ggtagttcca 840
gtgggaccaa cctgtgatga atatgcccaa aaggtacgac aacaattcca cgatgccaaa 900
ttcatggcag acattgatct ggatccaggc tgtacattga ataaaaagat tcgaaatgca 960
cagttagcac agtataactt cattttagtt gttggtgaaa aagagaaaat cagtggcact 1020
gttaatatcc gcacaagaga caataaggtc cacggggaac gcaccatttc tgaaactatc 1080
gagcggctac agcagctcaa agagttccgc agcaaacagg cagaagaaga attttaa    1137

<210> 54
<211> 292
<212> PRT
<213> Homo sapiens

<400> 54
Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly
 1               5                  10                  15      
Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala
            20                  25                  30          
His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys
        35                  40                  45              
Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys
    50                  55                  60                  
Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val
65                  70                  75                  80  
Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly
                85                  90                  95      
Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys
            100                 105                 110         
Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala
        115                 120                 125             
Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr
    130                 135                 140                 
Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg
145                 150                 155                 160 
Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn
                165                 170                 175     
Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val
            180                 185                 190         
Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln
        195                 200                 205             
Gln Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly
    210                 215                 220                 
Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn
225                 230                 235                 240 
Phe Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn
                245                 250                 255     
Ile Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu
            260                 265                 270         
Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala
        275                 280                 285             
Glu Glu Glu Phe
    290         


<210> 55
<211> 879
<212> DNA
<213> Homo sapiens

<400> 55
ctgcggctag ctgattttgg ggtacttcat aggaacgagc tgtctggagc actcacagga 60
ctcacccggg tacgaagatt ccaacaggat gatgctcaca tattctgtgc catggagcag 120
attgaagatg aaataaaagg ttgtttggat tttctacgta cggtatatag cgtatttgga 180
ttttctttta aactaaacct ttctactcgc ccggaaaaat tccttggaga tatcgaagta 240
tgggatcaag ctgagaaaca acttgaaaac agtctgaatg aatttggtga aaagtgggag 300
ttaaactctg gagatggagc tttctatggc ccaaagattg acatacagat taaagatgcg 360
attgggcggt accaccagtg tgcaaccatc cagctggatt tccagttgcc catcagattt 420
aatcttactt atgtaagcca tgatggtgat gataagaaaa ggccagtgat tgttcatcga 480
gccatcttgg gatcagtgga aagaatgatt gctatcctca cagaaaacta tgggggcaaa 540
tggccctttt ggctgtcccc tcgccaggta atggtagttc cagtgggacc aacctgtgat 600
gaatatgccc aaaaggtacg acaacaattc cacgatgcca aattcatggc agacattgat 660
ctggatccag gctgtacatt gaataaaaag attcgaaatg cacagttagc acagtataac 720
ttcattttag ttgttggtga aaaagagaaa atcagtggca ctgttaatat ccgcacaaga 780
gacaataagg tccacgggga acgcaccatt tctgaaacta tcgagcggct acagcagctc 840
aaagagttcc gcagcaaaca ggcagaagaa gaattttaa                        879

<210> 56
<211> 344
<212> PRT
<213> Homo sapiens

<400> 56
Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn
 1               5                  10                  15      
Met Phe Ser Phe Glu Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met
            20                  25                  30          
Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp
        35                  40                  45              
Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn
    50                  55                  60                  
Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln
65                  70                  75                  80  
Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu
                85                  90                  95      
Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly
            100                 105                 110         
Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly
        115                 120                 125             
Asp Ile Glu Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu
    130                 135                 140                 
Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe
145                 150                 155                 160 
Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr
                165                 170                 175     
His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe
            180                 185                 190         
Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val
        195                 200                 205             
Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile
    210                 215                 220                 
Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg
225                 230                 235                 240 
Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln
                245                 250                 255     
Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp
            260                 265                 270         
Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu
        275                 280                 285             
Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser
    290                 295                 300                 
Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg
305                 310                 315                 320 
Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg
                325                 330                 335     
Ser Lys Gln Ala Glu Glu Glu Phe
            340                 


<210> 57
<211> 1035
<212> DNA
<213> Homo sapiens

<400> 57
agccgactct ggatgacctc gggccactgg cagcactaca gcgagaacat gttctccttt 60
gaggtggaga aggagctgtt tgccctgaaa cccatgaact gcccaggaca ctgccttatg 120
tttgatcatc ggccaaggtc ctggcgagaa ctgcctctgc ggctagctga ttttggggta 180
cttcatagga acgagctgtc tggagcactc acaggactca cccgggtacg aagattccaa 240
caggatgatg ctcacatatt ctgtgccatg gagcagattg aagatgaaat aaaaggttgt 300
ttggattttc tacgtacggt atatagcgta tttggatttt cttttaaact aaacctttct 360
actcgcccgg aaaaattcct tggagatatc gaagtatggg atcaagctga gaaacaactt 420
gaaaacagtc tgaatgaatt tggtgaaaag tgggagttaa actctggaga tggagctttc 480
tatggcccaa agattgacat acagattaaa gatgcgattg ggcggtacca ccagtgtgca 540
accatccagc tggatttcca gttgcccatc agatttaatc ttacttatgt aagccatgat 600
ggtgatgata agaaaaggcc agtgattgtt catcgagcca tcttgggatc agtggaaaga 660
atgattgcta tcctcacaga aaactatggg ggcaaatggc ccttttggct gtcccctcgc 720
caggtaatgg tagttccagt gggaccaacc tgtgatgaat atgcccaaaa ggtacgacaa 780
caattccacg atgccaaatt catggcagac attgatctgg atccaggctg tacattgaat 840
aaaaagattc gaaatgcaca gttagcacag tataacttca ttttagttgt tggtgaaaaa 900
gagaaaatca gtggcactgt taatatccgc acaagagaca ataaggtcca cggggaacgc 960
accatttctg aaactatcga gcggctacag cagctcaaag agttccgcag caaacaggca 1020
gaagaagaat tttaa                                                  1035

<210> 58
<211> 430
<212> PRT
<213> Homo sapiens

<400> 58
Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp Pro Lys Met Leu Lys
 1               5                  10                  15      
Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp His Arg Lys
            20                  25                  30          
Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu Leu Ser Pro Gly
        35                  40                  45              
Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn Ala Leu Ile
    50                  55                  60                  
Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val
65                  70                  75                  80  
Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp
                85                  90                  95      
Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Leu
            100                 105                 110         
Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp
        115                 120                 125             
His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe
    130                 135                 140                 
Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr
145                 150                 155                 160 
Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met
                165                 170                 175     
Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr
            180                 185                 190         
Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg
        195                 200                 205             
Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln Ala Glu Lys
    210                 215                 220                 
Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn
225                 230                 235                 240 
Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys
                245                 250                 255     
Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe
            260                 265                 270         
Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp
        275                 280                 285             
Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val
    290                 295                 300                 
Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro
305                 310                 315                 320 
Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro Thr
                325                 330                 335     
Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys
            340                 345                 350         
Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys
        355                 360                 365             
Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly
    370                 375                 380                 
Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn
385                 390                 395                 400 
Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln
                405                 410                 415     
Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe
            420                 425                 430 


<210> 59
<211> 1293
<212> DNA
<213> Homo sapiens

<400> 59
ctccagagaa tttatggcat ttcattccca gatcctaaaa tgttgaaaga gtgggagaag 60
ttccaagagg aagctaaaaa ccgagatcat aggaaaattg gcagggacca agaactatat 120
ttctttcatg aactcagccc tggaagttgc ttttttctgc caaaaggagc ctacatttat 180
aatgcactta ttgaattcat taggagcgaa tataggaaaa gaggattcca ggaggtagtc 240
accccaaaca tcttcaacag ccgactctgg atgacctcgg gccactggca gcactacagc 300
gagaacatgt tctcctttga ggtggagaag gagctgtttg ccctgaaacc catgaactgc 360
ccaggacact gccttatgtt tgatcatcgg ccaaggtcct ggcgagaact gcctctgcgg 420
ctagctgatt ttggggtact tcataggaac gagctgtctg gagcactcac aggactcacc 480
cgggtacgaa gattccaaca ggatgatgct cacatattct gtgccatgga gcagattgaa 540
gatgaaataa aaggttgttt ggattttcta cgtacggtat atagcgtatt tggattttct 600
tttaaactaa acctttctac tcgcccggaa aaattccttg gagatatcga agtatgggat 660
caagctgaga aacaacttga aaacagtctg aatgaatttg gtgaaaagtg ggagttaaac 720
tctggagatg gagctttcta tggcccaaag attgacatac agattaaaga tgcgattggg 780
cggtaccacc agtgtgcaac catccagctg gatttccagt tgcccatcag atttaatctt 840
acttatgtaa gccatgatgg tgatgataag aaaaggccag tgattgttca tcgagccatc 900
ttgggatcag tggaaagaat gattgctatc ctcacagaaa actatggggg caaatggccc 960
ttttggctgt cccctcgcca ggtaatggta gttccagtgg gaccaacctg tgatgaatat 1020
gcccaaaagg tacgacaaca attccacgat gccaaattca tggcagacat tgatctggat 1080
ccaggctgta cattgaataa aaagattcga aatgcacagt tagcacagta taacttcatt 1140
ttagttgttg gtgaaaaaga gaaaatcagt ggcactgtta atatccgcac aagagacaat 1200
aaggtccacg gggaacgcac catttctgaa actatcgagc ggctacagca gctcaaagag 1260
ttccgcagca aacaggcaga agaagaattt taa                              1293

<210> 60
<211> 20
<212> PRT
<213> Mus musculus

<400> 60
Asp Gln Glu Leu Tyr Phe Phe His Glu Leu Ser Pro Gly Ser Cys Phe
 1               5                  10                  15      
Phe Leu Pro Lys
            20  


<210> 61
<211> 13
<212> PRT
<213> Mus musculus

<400> 61
Gly Ala Tyr Ile Tyr Asn Thr Leu Met Glu Phe Ile Arg
 1               5                  10              


<210> 62
<211> 81
<212> PRT
<213> Mus musculus

<400> 62
Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile
 1               5                  10                  15      
Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser
            20                  25                  30          
Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Gln Phe Ala Leu Lys
        35                  40                  45              
Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg
    50                  55                  60                  
Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His
65                  70                  75                  80  
Arg
    


<210> 63
<211> 12
<212> PRT
<213> Mus musculus

<400> 63
Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg
 1               5                  10          


<210> 64
<211> 3
<212> PRT
<213> Mus musculus

<400> 64
Val Arg Arg
 1          


<210> 65
<211> 20
<212> PRT
<213> Mus musculus

<400> 65
Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu
 1               5                  10                  15      
Asp Glu Ile Lys
            20  


<210> 66
<211> 149
<212> PRT
<213> Mus musculus

<400> 66
Asp Gln Glu Leu Tyr Phe Phe His Glu Leu Ser Pro Gly Ser Cys Phe
 1               5                  10                  15      
Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn Thr Leu Met Glu Phe Ile
            20                  25                  30          
Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn
        35                  40                  45              
Ile Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr
    50                  55                  60                  
Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Gln Phe Ala Leu
65                  70                  75                  80  
Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro
                85                  90                  95      
Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu
            100                 105                 110         
His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg
        115                 120                 125             
Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile
    130                 135                 140                 
Glu Asp Glu Ile Lys
145                 


<210> 67
<211> 13
<212> PRT
<213> Mus musculus

<400> 67
Gly Ala Tyr Ile Tyr Asn Thr Leu Met Glu Phe Ile Arg
 1               5                  10              


<210> 68
<211> 224
<212> PRT
<213> Mus musculus

<400> 68
Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile
 1               5                  10                  15      
Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser
            20                  25                  30          
Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Gln Phe Ala Leu Lys
        35                  40                  45              
Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg
    50                  55                  60                  
Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His
65                  70                  75                  80  
Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg
                85                  90                  95      
Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu
            100                 105                 110         
Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val
        115                 120                 125             
Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe
    130                 135                 140                 
Leu Gly Asp Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln Leu Glu Asn
145                 150                 155                 160 
Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro Gly Asp Gly
                165                 170                 175     
Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly
            180                 185                 190         
Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile
        195                 200                 205             
Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg
    210                 215                 220                 


<210> 69
<211> 25
<212> PRT
<213> Mus musculus

<400> 69
Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile
 1               5                  10                  15      
Ala Ile Leu Thr Glu Asn Tyr Gly Gly
            20                  25  


<210> 70
<211> 262
<212> PRT
<213> Mus musculus

<400> 70
Gly Ala Tyr Ile Tyr Asn Thr Leu Met Glu Phe Ile Arg Ser Glu Tyr
 1               5                  10                  15      
Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser
            20                  25                  30          
Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met
        35                  40                  45              
Phe Ser Phe Glu Val Glu Lys Glu Gln Phe Ala Leu Lys Pro Met Asn
    50                  55                  60                  
Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg
65                  70                  75                  80  
Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu
                85                  90                  95      
Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln
            100                 105                 110         
Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile
        115                 120                 125             
Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe
    130                 135                 140                 
Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp
145                 150                 155                 160 
Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn
                165                 170                 175     
Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro Gly Asp Gly Ala Phe Tyr
            180                 185                 190         
Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His
        195                 200                 205             
Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn
    210                 215                 220                 
Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile
225                 230                 235                 240 
Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu
                245                 250                 255     
Thr Glu Asn Tyr Gly Gly
            260         


<210> 71
<211> 12
<212> PRT
<213> Mus musculus

<400> 71
Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg
 1               5                  10          


<210> 72
<211> 165
<212> PRT
<213> Mus musculus

<400> 72
Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu
 1               5                  10                  15      
Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val
            20                  25                  30          
Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro
        35                  40                  45              
Glu Lys Phe Leu Gly Asp Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln
    50                  55                  60                  
Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro
65                  70                  75                  80  
Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp
                85                  90                  95      
Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln
            100                 105                 110         
Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp
        115                 120                 125             
Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu
    130                 135                 140                 
Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe
145                 150                 155                 160 
Trp Leu Ser Pro Arg
                165 


<210> 73
<211> 17
<212> PRT
<213> Mus musculus

<400> 73
Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln
 1               5                  10                  15      
Lys
    


<210> 74
<211> 194
<212> PRT
<213> Mus musculus

<400> 74
Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe
 1               5                  10                  15      
Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp
            20                  25                  30          
Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe
        35                  40                  45              
Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu
    50                  55                  60                  
Gly Asp Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln Leu Glu Asn Ser
65                  70                  75                  80  
Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro Gly Asp Gly Ala
                85                  90                  95      
Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg
            100                 105                 110         
Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg
        115                 120                 125             
Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro
    130                 135                 140                 
Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala
145                 150                 155                 160 
Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro
                165                 170                 175     
Arg Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala
            180                 185                 190         
Gln Lys
        


<210> 75
<211> 12
<212> PRT
<213> Mus musculus

<400> 75
Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg
 1               5                  10          


<210> 76
<211> 145
<212> PRT
<213> Mus musculus

<400> 76
Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu
 1               5                  10                  15      
Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val
            20                  25                  30          
Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro
        35                  40                  45              
Glu Lys Phe Leu Gly Asp Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln
    50                  55                  60                  
Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro
65                  70                  75                  80  
Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp
                85                  90                  95      
Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln
            100                 105                 110         
Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp
        115                 120                 125             
Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu
    130                 135                 140                 
Arg
145 


<210> 77
<211> 12
<212> PRT
<213> Mus musculus

<400> 77
Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys
 1               5                  10          


<210> 78
<211> 169
<212> PRT
<213> mus musculus

<400> 78
Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe
 1               5                  10                  15      
Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp
            20                  25                  30          
Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe
        35                  40                  45              
Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu
    50                  55                  60                  
Gly Asp Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln Leu Glu Asn Ser
65                  70                  75                  80  
Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro Gly Asp Gly Ala
                85                  90                  95      
Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg
            100                 105                 110         
Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg
        115                 120                 125             
Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro
    130                 135                 140                 
Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala
145                 150                 155                 160 
Ile Leu Thr Glu Asn Tyr Gly Gly Lys
                165                 


<210> 79
<211> 10
<212> PRT
<213> Mus musculus

<400> 79
Ile Tyr Gly Ile Ser Phe Pro Asp Pro Lys
 1               5                  10  


<210> 80
<211> 61
<212> PRT
<213> Mus musculus

<400> 80
Leu Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp
 1               5                  10                  15      
His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu Leu
            20                  25                  30          
Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn
        35                  40                  45              
Thr Leu Met Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg
    50                  55                  60      


<210> 81
<211> 14
<212> PRT
<213> Mus musculus

<400> 81
Gly Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg
 1               5                  10                  


<210> 82
<211> 218
<212> PRT
<213> Mus musculus

<400> 82
Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe
 1               5                  10                  15      
Ser Phe Glu Val Glu Lys Glu Gln Phe Ala Leu Lys Pro Met Asn Cys
            20                  25                  30          
Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu
        35                  40                  45              
Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu
    50                  55                  60                  
Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp
65                  70                  75                  80  
Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys
                85                  90                  95      
Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser
            100                 105                 110         
Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile
        115                 120                 125             
Glu Ile Trp Asn Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu
    130                 135                 140                 
Phe Gly Glu Lys Trp Glu Leu Asn Pro Gly Asp Gly Ala Phe Tyr Gly
145                 150                 155                 160 
Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln
                165                 170                 175     
Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu
            180                 185                 190         
Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val
        195                 200                 205             
His Arg Ala Ile Leu Gly Ser Val Glu Arg
    210                 215             


<210> 83
<211> 12
<212> PRT
<213> Mus musculus

<400> 83
Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys
 1               5                  10          


<210> 84
<211> 315
<212> PRT
<213> Mus musculus

<400> 84
Ile Tyr Gly Ile Ser Phe Pro Asp Pro Lys Leu Leu Lys Glu Trp Glu
 1               5                  10                  15      
Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp His Arg Lys Ile Gly Arg
            20                  25                  30          
Asp Gln Glu Leu Tyr Phe Phe His Glu Leu Ser Pro Gly Ser Cys Phe
        35                  40                  45              
Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn Thr Leu Met Glu Phe Ile
    50                  55                  60                  
Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn
65                  70                  75                  80  
Ile Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr
                85                  90                  95      
Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Gln Phe Ala Leu
            100                 105                 110         
Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro
        115                 120                 125             
Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu
    130                 135                 140                 
His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg
145                 150                 155                 160 
Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile
                165                 170                 175     
Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser
            180                 185                 190         
Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys
        195                 200                 205             
Phe Leu Gly Asp Ile Glu Ile Trp Asn Gln Ala Glu Lys Gln Leu Glu
    210                 215                 220                 
Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Pro Gly Asp
225                 230                 235                 240 
Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile
                245                 250                 255     
Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro
            260                 265                 270         
Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys
        275                 280                 285             
Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met
    290                 295                 300                 
Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys
305                 310                 315 


<210> 85
<211> 124
<212> PRT
<213> Homo sapiens

<400> 85
Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp
 1               5                  10                  15      
Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp
            20                  25                  30          
Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe Met
        35                  40                  45              
Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile Arg
    50                  55                  60                  
Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu Lys
65                  70                  75                  80  
Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys Val
                85                  90                  95      
His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln Leu
            100                 105                 110         
Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe
        115                 120                 


<210> 86
<211> 375
<212> DNA
<213> Homo sapiens

<400> 86
atgattgcta tcctcacaga aaactatggg ggcaaatggc ccttttggct gtcccctcgc 60
caggtaatgg tagttccagt gggaccaacc tgtgatgaat atgcccaaaa ggtacgacaa 120
caattccacg atgccaaatt catggcagac attgatctgg atccaggctg tacattgaat 180
aaaaagattc gaaatgcaca gttagcacag tataacttca ttttagttgt tggtgaaaaa 240
gagaaaatca gtggcactgt taatatccgc acaagagaca ataaggtcca cggggaacgc 300
accatttctg aaactatcga gcggctacag cagctcaaag agttccgcag caaacaggca 360
gaagaagaat tttaa                                                  375

<210> 87
<211> 696
<212> PRT
<213> Homo sapiens

<400> 87
Met Phe Glu Glu Lys Ala Ser Ser Pro Ser Gly Lys Met Gly Gly Glu
 1               5                  10                  15      
Glu Lys Pro Leu Asn Pro Trp Pro Glu Tyr Ile Tyr Thr Arg Leu Glu
            20                  25                  30          
Met Tyr Asn Ile Leu Lys Ala Glu His Asp Ser Ile Leu Ala Glu Lys
        35                  40                  45              
Ala Glu Lys Asp Ser Lys Pro Ile Lys Val Thr Leu Pro Asp Gly Lys
    50                  55                  60                  
Gln Val Asp Ala Glu Ser Trp Lys Thr Thr Pro Tyr Gln Ile Ala Cys
65                  70                  75                  80  
Gly Ile Ser Gln Gly Leu Ala Asp Asn Thr Val Ile Ala Lys Val Asn
                85                  90                  95      
Asn Val Val Trp Asp Leu Asp Arg Pro Leu Glu Glu Asp Cys Thr Leu
            100                 105                 110         
Glu Leu Leu Lys Phe Glu Asp Glu Glu Ala Gln Ala Val Tyr Trp His
        115                 120                 125             
Ser Ser Ala His Ile Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly
    130                 135                 140                 
Cys Leu Cys Tyr Gly Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met
145                 150                 155                 160 
Tyr Leu Glu Glu Gly Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu
                165                 170                 175     
Ala Leu Cys Lys Lys Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu
            180                 185                 190         
Glu Val Lys Lys Glu Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe
        195                 200                 205             
Lys Cys Arg Ile Leu Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val
    210                 215                 220                 
Tyr Arg Cys Gly Pro Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg
225                 230                 235                 240 
His Thr Gly Lys Ile Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr
                245                 250                 255     
Tyr Trp Glu Gly Lys Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly
            260                 265                 270         
Ile Ser Phe Pro Asp Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln
        275                 280                 285             
Glu Glu Ala Lys Asn Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu
    290                 295                 300                 
Leu Tyr Phe Phe His Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro
305                 310                 315                 320 
Lys Gly Ala Tyr Ile Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu
                325                 330                 335     
Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn
            340                 345                 350         
Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn
        355                 360                 365             
Met Phe Ser Phe Glu Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met
    370                 375                 380                 
Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp
385                 390                 395                 400 
Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn
                405                 410                 415     
Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln
            420                 425                 430         
Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu
        435                 440                 445             
Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly
    450                 455                 460                 
Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly
465                 470                 475                 480 
Asp Ile Glu Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu
                485                 490                 495     
Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe
            500                 505                 510         
Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr
        515                 520                 525             
His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe
    530                 535                 540                 
Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val
545                 550                 555                 560 
Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile
                565                 570                 575     
Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg
            580                 585                 590         
Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln
        595                 600                 605             
Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp
    610                 615                 620                 
Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu
625                 630                 635                 640 
Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser
                645                 650                 655     
Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg
            660                 665                 670         
Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg
        675                 680                 685             
Ser Lys Gln Ala Glu Glu Glu Phe
    690                 695     


<210> 88
<211> 2091
<212> DNA
<213> Homo sapiens

<400> 88
atgtttgagg agaaggccag cagtccttca gggaagatgg gaggcgagga gaagccgttg 60
aatccttggc ctgaatatat ttacacacgt cttgagatgt ataatatact aaaagcagaa 120
catgattcca ttctggcaga aaaggcagaa aaagatagca agccaattaa agtcactttg 180
cctgatggta aacaggttga tgcggaatct tggaaaacta caccatatca aattgcctgt 240
ggaattagtc aaggcctggc cgacaacacc gttattgcta aagtaaataa tgttgtgtgg 300
gacctggacc gccctctgga agaagattgt accttggagc ttctcaagtt tgaggatgag 360
gaagctcagg cagtgtattg gcactctagt gctcacataa tgggtgaagc catggaaaga 420
gtctatggtg gatgtttatg ctacggtccg ccaatagaaa atggattcta ttatgacatg 480
tacctcgaag aagggggtgt gtctagcaat gatttctctt ctctggaggc tttgtgtaag 540
aaaatcatta aagaaaaaca agcttttgaa agactggaag ttaagaaaga aactttactg 600
gcaatgttta agtacaacaa gttcaaatgc cggatattga atgaaaaggt gaatactcca 660
actaccacag tctatagatg tggccctttg atagatctct gccggggtcc tcatgttaga 720
cacacgggca aaattaaggc tttaaaaata cacaaaaatt cctccacgta ctgggaaggc 780
aaagcagata tggagactct ccagagaatt tatggcattt cattcccaga tcctaaaatg 840
ttgaaagagt gggagaagtt ccaagaggaa gctaaaaacc gagatcatag gaaaattggc 900
agggaccaag aactatattt ctttcatgaa ctcagccctg gaagttgctt ttttctgcca 960
aaaggagcct acatttataa tgcacttatt gaattcatta ggagcgaata taggaaaaga 1020
ggattccagg aggtagtcac cccaaacatc ttcaacagcc gactctggat gacctcgggc 1080
cactggcagc actacagcga gaacatgttc tcctttgagg tggagaagga gctgtttgcc 1140
ctgaaaccca tgaactgccc aggacactgc cttatgtttg atcatcggcc aaggtcctgg 1200
cgagaactgc ctctgcggct agctgatttt ggggtacttc ataggaacga gctgtctgga 1260
gcactcacag gactcacccg ggtacgaaga ttccaacagg atgatgctca catattctgt 1320
gccatggagc agattgaaga tgaaataaaa ggttgtttgg attttctacg tacggtatat 1380
agcgtatttg gattttcttt taaactaaac ctttctactc gcccggaaaa attccttgga 1440
gatatcgaag tatgggatca agctgagaaa caacttgaaa acagtctgaa tgaatttggt 1500
gaaaagtggg agttaaactc tggagatgga gctttctatg gcccaaagat tgacatacag 1560
attaaagatg cgattgggcg gtaccaccag tgtgcaacca tccagctgga tttccagttg 1620
cccatcagat ttaatcttac ttatgtaagc catgatggtg atgataagaa aaggccagtg 1680
attgttcatc gagccatctt gggatcagtg gaaagaatga ttgctatcct cacagaaaac 1740
tatgggggca aatggccctt ttggctgtcc cctcgccagg taatggtagt tccagtggga 1800
ccaacctgtg atgaatatgc ccaaaaggta cgacaacaat tccacgatgc caaattcatg 1860
gcagacattg atctggatcc aggctgtaca ttgaataaaa agattcgaaa tgcacagtta 1920
gcacagtata acttcatttt agttgttggt gaaaaagaga aaatcagtgg cactgttaat 1980
atccgcacaa gagacaataa ggtccacggg gaacgcacca tttctgaaac tatcgagcgg 2040
ctacagcagc tcaaagagtt ccgcagcaaa caggcagaag aagaatttta a          2091

<210> 89
<211> 563
<212> PRT
<213> Homo sapiens

<400> 89
Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly
 1               5                  10                  15      
Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly
            20                  25                  30          
Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys
        35                  40                  45              
Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu
    50                  55                  60                  
Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu
65                  70                  75                  80  
Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro
                85                  90                  95      
Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile
            100                 105                 110         
Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys
        115                 120                 125             
Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp
    130                 135                 140                 
Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn
145                 150                 155                 160 
Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His
                165                 170                 175     
Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile
            180                 185                 190         
Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly
        195                 200                 205             
Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met
    210                 215                 220                 
Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu
225                 230                 235                 240 
Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His
                245                 250                 255     
Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu
            260                 265                 270         
Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala
        275                 280                 285             
Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His
    290                 295                 300                 
Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu
305                 310                 315                 320 
Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu
                325                 330                 335     
Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp
            340                 345                 350         
Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu
        355                 360                 365             
Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile
    370                 375                 380                 
Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr
385                 390                 395                 400 
Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val
                405                 410                 415     
Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala
            420                 425                 430         
Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr
        435                 440                 445             
Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val
    450                 455                 460                 
Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln
465                 470                 475                 480 
Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys
                485                 490                 495     
Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe
            500                 505                 510         
Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile
        515                 520                 525             
Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr
    530                 535                 540                 
Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu
545                 550                 555                 560 
Glu Glu Phe
            


<210> 90
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 90
atgggtgaag ccatggaaag agtctatggt ggatgtttat gctacggtcc gccaatagaa 60
aatggattct attatgacat gtacctcgaa gaagggggtg tgtctagcaa tgatttctct 120
tctctggagg ctttgtgtaa gaaaatcatt aaagaaaaac aagcttttga aagactggaa 180
gttaagaaag aaactttact ggcaatgttt aagtacaaca agttcaaatg ccggatattg 240
aatgaaaagg tgaatactcc aactaccaca gtctatagat gtggcccttt gatagatctc 300
tgccggggtc ctcatgttag acacacgggc aaaattaagg ctttaaaaat acacaaaaat 360
tcctccacgt actgggaagg caaagcagat atggagactc tccagagaat ttatggcatt 420
tcattcccag atcctaaaat gttgaaagag tgggagaagt tccaagagga agctaaaaac 480
cgagatcata ggaaaattgg cagggaccaa gaactatatt tctttcatga actcagccct 540
ggaagttgct tttttctgcc aaaaggagcc tacatttata atgcacttat tgaattcatt 600
aggagcgaat ataggaaaag aggattccag gaggtagtca ccccaaacat cttcaacagc 660
cgactctgga tgacctcggg ccactggcag cactacagcg agaacatgtt ctcctttgag 720
gtggagaagg agctgtttgc cctgaaaccc atgaactgcc caggacactg ccttatgttt 780
gatcatcggc caaggtcctg gcgagaactg cctctgcggc tagctgattt tggggtactt 840
cataggaacg agctgtctgg agcactcaca ggactcaccc gggtacgaag attccaacag 900
gatgatgctc acatattctg tgccatggag cagattgaag atgaaataaa aggttgtttg 960
gattttctac gtacggtata tagcgtattt ggattttctt ttaaactaaa cctttctact 1020
cgcccggaaa aattccttgg agatatcgaa gtatgggatc aagctgagaa acaacttgaa 1080
aacagtctga atgaatttgg tgaaaagtgg gagttaaact ctggagatgg agctttctat 1140
ggcccaaaga ttgacataca gattaaagat gcgattgggc ggtaccacca gtgtgcaacc 1200
atccagctgg atttccagtt gcccatcaga tttaatctta cttatgtaag ccatgatggt 1260
gatgataaga aaaggccagt gattgttcat cgagccatct tgggatcagt ggaaagaatg 1320
attgctatcc tcacagaaaa ctatgggggc aaatggccct tttggctgtc ccctcgccag 1380
gtaatggtag ttccagtggg accaacctgt gatgaatatg cccaaaaggt acgacaacaa 1440
ttccacgatg ccaaattcat ggcagacatt gatctggatc caggctgtac attgaataaa 1500
aagattcgaa atgcacagtt agcacagtat aacttcattt tagttgttgg tgaaaaagag 1560
aaaatcagtg gcactgttaa tatccgcaca agagacaata aggtccacgg ggaacgcacc 1620
atttctgaaa ctatcgagcg gctacagcag ctcaaagagt tccgcagcaa acaggcagaa 1680
gaagaatttt aa                                                     1692

<210> 91
<211> 50
<212> DNA
<213> Homo sapiens

<400> 91
ccgagatcat aggaaaattg gcaggccatg atggtgatga taagaaaagg            50

<210> 92

<400> 92
 000

<210> 93
<211> 50
<212> DNA
<213> Homo sapiens

<400> 93
gaagatggga ggcgaggaga agccgttgaa tccttggcct gaatatattt            50

<210> 94
<211> 16
<212> PRT
<213> Homo sapiens

<400> 94
Lys Met Gly Gly Glu Glu Lys Pro Leu Asn Pro Trp Pro Glu Tyr Ile
 1               5                  10                  15      


<210> 95
<211> 50
<212> DNA
<213> Homo sapiens

<400> 95
catatcaaat tgcctgtgga attaggtgta ttggcactct agtgctcaca            50

<210> 96

<400> 96
 000

<210> 97
<211> 437
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 97
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala
            20                  25                  30          
Lys Asn Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe
        35                  40                  45              
Phe His Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala
    50                  55                  60                  
Tyr Ile Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys
65                  70                  75                  80  
Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu
                85                  90                  95      
Trp Met Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser
            100                 105                 110         
Phe Glu Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro
        115                 120                 125             
Gly His Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu
    130                 135                 140                 
Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser
145                 150                 155                 160 
Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp
                165                 170                 175     
Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly
            180                 185                 190         
Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe
        195                 200                 205             
Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu
    210                 215                 220                 
Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe
225                 230                 235                 240 
Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro
                245                 250                 255     
Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys
            260                 265                 270         
Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr
        275                 280                 285             
Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His
    290                 295                 300                 
Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu
305                 310                 315                 320 
Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met
                325                 330                 335     
Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg
            340                 345                 350         
Gln Gln Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro
        355                 360                 365             
Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr
    370                 375                 380                 
Asn Phe Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val
385                 390                 395                 400 
Asn Ile Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser
                405                 410                 415     
Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln
            420                 425                 430         
Ala Glu Glu Glu Phe
        435         


<210> 98
<211> 437
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 98
Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp
 1               5                  10                  15      
His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu Leu
            20                  25                  30          
Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn
        35                  40                  45              
Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln
    50                  55                  60                  
Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser
65                  70                  75                  80  
Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu
                85                  90                  95      
Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu
            100                 105                 110         
Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu
        115                 120                 125             
Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr
    130                 135                 140                 
Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe
145                 150                 155                 160 
Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe
                165                 170                 175     
Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu
            180                 185                 190         
Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln
        195                 200                 205             
Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp
    210                 215                 220                 
Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile
225                 230                 235                 240 
Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln
                245                 250                 255     
Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His
            260                 265                 270         
Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu
        275                 280                 285             
Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly
    290                 295                 300                 
Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val
305                 310                 315                 320 
Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His
                325                 330                 335     
Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu
            340                 345                 350         
Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu
        355                 360                 365             
Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr
    370                 375                 380                 
Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu
385                 390                 395                 400 
Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu
                405                 410                 415     
Phe Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
            420                 425                 430         
His His His His His
        435         


<210> 99
<211> 403
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 99
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Leu Pro Lys Gly Ala Tyr Ile Tyr Asn
            20                  25                  30          
Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln
        35                  40                  45              
Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser
    50                  55                  60                  
Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu
65                  70                  75                  80  
Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu
                85                  90                  95      
Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu
            100                 105                 110         
Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr
        115                 120                 125             
Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe
    130                 135                 140                 
Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe
145                 150                 155                 160 
Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu
                165                 170                 175     
Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln
            180                 185                 190         
Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp
        195                 200                 205             
Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile
    210                 215                 220                 
Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln
225                 230                 235                 240 
Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His
                245                 250                 255     
Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu
            260                 265                 270         
Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly
        275                 280                 285             
Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val
    290                 295                 300                 
Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His
305                 310                 315                 320 
Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu
                325                 330                 335     
Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu
            340                 345                 350         
Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr
        355                 360                 365             
Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu
    370                 375                 380                 
Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu
385                 390                 395                 400 
Phe Leu Glu
            


<210> 100
<211> 403
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 100
Met Gly Ser Leu Pro Lys Gly Ala Tyr Ile Tyr Asn Ala Leu Ile Glu
 1               5                  10                  15      
Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val Val Thr
            20                  25                  30          
Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln
        35                  40                  45              
His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Leu Phe
    50                  55                  60                  
Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His
65                  70                  75                  80  
Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly
                85                  90                  95      
Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg
            100                 105                 110         
Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu
        115                 120                 125             
Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val
    130                 135                 140                 
Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro
145                 150                 155                 160 
Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln Ala Glu Lys Gln
                165                 170                 175     
Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Ser
            180                 185                 190         
Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp
        195                 200                 205             
Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln
    210                 215                 220                 
Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp
225                 230                 235                 240 
Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu
                245                 250                 255     
Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe
            260                 265                 270         
Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro Thr Cys
        275                 280                 285             
Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe
    290                 295                 300                 
Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile
305                 310                 315                 320 
Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu
                325                 330                 335     
Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys
            340                 345                 350         
Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln
        355                 360                 365             
Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe Leu Glu Gly
    370                 375                 380                 
Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His
385                 390                 395                 400 
His His His
            


<210> 101
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 101
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg
            20                  25                  30          
Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe
        35                  40                  45              
Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp
    50                  55                  60                  
Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe
65                  70                  75                  80  
Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu
                85                  90                  95      
Gly Asp Ile Glu Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser
            100                 105                 110         
Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala
        115                 120                 125             
Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg
    130                 135                 140                 
Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg
145                 150                 155                 160 
Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro
                165                 170                 175     
Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala
            180                 185                 190         
Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro
        195                 200                 205             
Arg Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala
    210                 215                 220                 
Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe Met Ala Asp Ile
225                 230                 235                 240 
Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln
                245                 250                 255     
Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu Lys Glu Lys Ile
            260                 265                 270         
Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys Val His Gly Glu
        275                 280                 285             
Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe
    290                 295                 300                 
Arg Ser Lys Gln Ala Glu Glu Glu Phe
305                 310             


<210> 102
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 102
Met Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser
 1               5                  10                  15      
Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp
            20                  25                  30          
Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly
        35                  40                  45              
Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe
    50                  55                  60                  
Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu
65                  70                  75                  80  
Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe
                85                  90                  95      
Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro
            100                 105                 110         
Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys
        115                 120                 125             
Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr
    130                 135                 140                 
Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His
145                 150                 155                 160 
Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu
                165                 170                 175     
Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met
            180                 185                 190         
Val Val Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg
        195                 200                 205             
Gln Gln Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro
    210                 215                 220                 
Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr
225                 230                 235                 240 
Asn Phe Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val
                245                 250                 255     
Asn Ile Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser
            260                 265                 270         
Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln
        275                 280                 285             
Ala Glu Glu Glu Phe Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
    290                 295                 300                 
Asp Ser Thr His His His His His His
305                 310             


<210> 103
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 103
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Arg Leu Trp Met Thr Ser Gly His
            20                  25                  30          
Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu
        35                  40                  45              
Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe
    50                  55                  60                  
Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp
65                  70                  75                  80  
Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu
                85                  90                  95      
Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala
            100                 105                 110         
Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg
        115                 120                 125             
Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr
    130                 135                 140                 
Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln Ala Glu
145                 150                 155                 160 
Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu
                165                 170                 175     
Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile
            180                 185                 190         
Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp
        195                 200                 205             
Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly
    210                 215                 220                 
Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser
225                 230                 235                 240 
Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp
                245                 250                 255     
Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro
            260                 265                 270         
Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala
        275                 280                 285             
Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys
    290                 295                 300                 
Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val
305                 310                 315                 320 
Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp
                325                 330                 335     
Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu
            340                 345                 350         
Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe Leu
        355                 360                 365             
Glu
    


<210> 104
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 104
Met Gly Ser Ser Arg Leu Trp Met Thr Ser Gly His Trp Gln His Tyr
 1               5                  10                  15      
Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu Leu Phe Ala Leu
            20                  25                  30          
Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe Asp His Arg Pro
        35                  40                  45              
Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu
    50                  55                  60                  
His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg
65                  70                  75                  80  
Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile
                85                  90                  95      
Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser
            100                 105                 110         
Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys
        115                 120                 125             
Phe Leu Gly Asp Ile Glu Val Trp Asp Gln Ala Glu Lys Gln Leu Glu
    130                 135                 140                 
Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp
145                 150                 155                 160 
Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile
                165                 170                 175     
Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro
            180                 185                 190         
Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys
        195                 200                 205             
Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser Val Glu Arg Met
    210                 215                 220                 
Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu
225                 230                 235                 240 
Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro Thr Cys Asp Glu
                245                 250                 255     
Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys Phe Met Ala
            260                 265                 270         
Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys Ile Arg Asn
        275                 280                 285             
Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly Glu Lys Glu
    290                 295                 300                 
Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn Lys Val His
305                 310                 315                 320 
Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln Gln Leu Lys
                325                 330                 335     
Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe Leu Glu Gly Lys Pro
            340                 345                 350         
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
        355                 360                 365             
His
    


<210> 105
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 105
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp
            20                  25                  30          
Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn
        35                  40                  45              
Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His
    50                  55                  60                  
Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile
65                  70                  75                  80  
Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly
                85                  90                  95      
Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met
            100                 105                 110         
Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu
        115                 120                 125             
Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His
    130                 135                 140                 
Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu
145                 150                 155                 160 
Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala
                165                 170                 175     
Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His
            180                 185                 190         
Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu
        195                 200                 205             
Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu
    210                 215                 220                 
Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp
225                 230                 235                 240 
Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu
                245                 250                 255     
Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile
            260                 265                 270         
Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr
        275                 280                 285             
Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val
    290                 295                 300                 
Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala
305                 310                 315                 320 
Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr
                325                 330                 335     
Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val
            340                 345                 350         
Pro Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln
        355                 360                 365             
Phe His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys
    370                 375                 380                 
Thr Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe
385                 390                 395                 400 
Ile Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile
                405                 410                 415     
Arg Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr
            420                 425                 430         
Ile Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu
        435                 440                 445             
Glu Glu Phe
    450     


<210> 106
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 106
Met Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp Pro Lys Met Leu
 1               5                  10                  15      
Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp His Arg
            20                  25                  30          
Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu Leu Ser Pro
        35                  40                  45              
Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn Ala Leu
    50                  55                  60                  
Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln Glu Val
65                  70                  75                  80  
Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser Gly His
                85                  90                  95      
Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu Lys Glu
            100                 105                 110         
Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu Met Phe
        115                 120                 125             
Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu Ala Asp
    130                 135                 140                 
Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr Gly Leu
145                 150                 155                 160 
Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe Cys Ala
                165                 170                 175     
Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe Leu Arg
            180                 185                 190         
Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu Ser Thr
        195                 200                 205             
Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln Ala Glu
    210                 215                 220                 
Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp Glu Leu
225                 230                 235                 240 
Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile Gln Ile
                245                 250                 255     
Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln Leu Asp
            260                 265                 270         
Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His Asp Gly
        275                 280                 285             
Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu Gly Ser
    290                 295                 300                 
Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp
305                 310                 315                 320 
Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro
                325                 330                 335     
Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala
            340                 345                 350         
Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys
        355                 360                 365             
Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val
    370                 375                 380                 
Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp
385                 390                 395                 400 
Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu
                405                 410                 415     
Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe Gly
            420                 425                 430         
Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His
        435                 440                 445             
His His His
    450     


<210> 107
<211> 148
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 107
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ile Ala Ile Leu Thr Glu Asn Tyr Gly
            20                  25                  30          
Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro
        35                  40                  45              
Val Gly Pro Thr Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe
    50                  55                  60                  
His Asp Ala Lys Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr
65                  70                  75                  80  
Leu Asn Lys Lys Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile
                85                  90                  95      
Leu Val Val Gly Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg
            100                 105                 110         
Thr Arg Asp Asn Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile
        115                 120                 125             
Glu Arg Leu Gln Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu
    130                 135                 140                 
Glu Phe Leu Glu
145             


<210> 108
<211> 148
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 108
Met Gly Ser Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly Lys Trp Pro
 1               5                  10                  15      
Phe Trp Leu Ser Pro Arg Gln Val Met Val Val Pro Val Gly Pro Thr
            20                  25                  30          
Cys Asp Glu Tyr Ala Gln Lys Val Arg Gln Gln Phe His Asp Ala Lys
        35                  40                  45              
Phe Met Ala Asp Ile Asp Leu Asp Pro Gly Cys Thr Leu Asn Lys Lys
    50                  55                  60                  
Ile Arg Asn Ala Gln Leu Ala Gln Tyr Asn Phe Ile Leu Val Val Gly
65                  70                  75                  80  
Glu Lys Glu Lys Ile Ser Gly Thr Val Asn Ile Arg Thr Arg Asp Asn
                85                  90                  95      
Lys Val His Gly Glu Arg Thr Ile Ser Glu Thr Ile Glu Arg Leu Gln
            100                 105                 110         
Gln Leu Lys Glu Phe Arg Ser Lys Gln Ala Glu Glu Glu Phe Leu Glu
        115                 120                 125             
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
    130                 135                 140                 
His His His His
145             


<210> 109
<211> 1260
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 109
ctgaaagaat gggagaagtt ccaggaagag gccaaaaacc gcgatcatcg taagattggc 60
cgtgaccagg agctgtactt tttccacgag ctgagcccgg gtagctgctt tttcctgccg 120
aaaggcgcgt acatctataa cgctttgatc gaattcatcc gcagcgagta ccgtaagcgt 180
ggttttcaag aggtcgtcac tccgaatatc ttcaacagcc gtctgtggat gacttctggt 240
cactggcagc actacagcga gaatatgttt agcttcgagg ttgaaaaaga gctgtttgcc 300
ctgaagccga tgaactgtcc gggccattgc ctgatgttcg atcaccgtcc gcgttcctgg 360
cgcgagctgc cgctgcgcct ggcggatttt ggtgtgttgc accgcaatga gctgagcggt 420
gcgctgaccg gtctgacccg cgttcgccgt tttcagcaag atgacgcgca cattttctgc 480
gcgatggagc aaatcgagga tgagattaag ggttgtctgg acttcctgcg taccgtgtat 540
tccgttttcg gctttagctt taaactgaac ttgtctaccc gtccggaaaa gtttttgggt 600
gacattgagg tctgggatca agcagagaag caactggaga acagcctgaa cgaattcggt 660
gaaaagtggg aactgaatag cggtgacggc gcgttctacg gtcctaagat cgacatccaa 720
atcaaagatg cgatcggccg ttatcaccag tgcgctacga tccagttgga cttccagttg 780
ccaatccgct tcaacctgac ctatgtgtcg catgacggcg acgacaagaa acgtccggtc 840
atcgttcatc gtgcaattct gggtagcgtc gagcgcatga ttgcgattct gaccgagaat 900
tatggtggta aatggccgtt ttggctgtcc cctcgccagg tgatggtggt tccggttggc 960
ccgacctgtg atgaatacgc acagaaagtt cgtcaacaat ttcacgatgc aaagtttatg 1020
gcggacattg atctggatcc gggttgcacg ctgaataaga aaattcgtaa tgcccagctg 1080
gcccaataca acttcatcct ggtcgtgggc gagaaagaga agattagcgg cacggttaac 1140
attcgtacgc gtgacaataa ggtgcatggt gaacgtacca ttagcgaaac gattgaacgt 1200
ctgcagcaac tgaaagaatt ccgcagcaaa caggcagaag aagaattcta atgactcgag 1260


<210> 110
<211> 1146
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 110
ggatccctgc cgaaaggcgc ttatatctat aatgccctga tcgagtttat tcgctcggag 60
tatcgtaaac gtggctttca ggaagttgtt acgcctaaca tttttaacag tcgcctgtgg 120
atgacatctg gtcactggca acactattct gagaacatgt tcagcttcga agtggagaaa 180
gagctgtttg ctctgaaacc gatgaattgt ccgggtcatt gtctgatgtt tgatcaccgt 240
cctcgttctt ggcgtgaact gccactgcgt ctggctgact ttggtgtgct gcaccgtaat 300
gaactgtctg gtgctctgac aggtctgaca cgtgtccgtc gtttccagca ggatgatgcc 360
cacatctttt gtgccatgga gcagatcgaa gatgagatca aaggttgcct ggattttctg 420
cgcacagtgt atagcgtgtt cgggttttcc ttcaaactga atctgagtac ccgtccagag 480
aaatttctgg gcgatatcga ggtttgggac caagccgaaa aacaactgga gaacagcctg 540
aacgaatttg gcgagaaatg ggaactgaac tcgggtgatg gtgcctttta tggccctaaa 600
atcgacatcc agattaaaga cgccattggc cgctatcatc agtgtgccac cattcagctg 660
gactttcagc tgcctattcg cttcaacctg acctatgtga gccatgatgg agatgacaaa 720
aaacgtccgg tcatcgtaca ccgtgctatc ctgggttctg ttgagcgtat gattgccatt 780
ctgaccgaga attatggcgg aaaatggccg ttttggctgt cacctcgtca agtgatggtt 840
gttccggttg gaccaacttg tgatgagtat gctcaaaaag ttcgtcaaca atttcacgat 900
gccaaattca tggccgacat cgatctggac cctggttgta ccctgaacaa aaaaatccgt 960
aacgcccagc tggcacagta taactttatc ctggtcgtgg gcgaaaaaga aaaaatcagc 1020
ggcaccgtta atattcgtac tcgtgataac aaagttcatg gggagcgtac cattagtgag 1080
actatcgaac gtctgcaaca gctgaaagag ttccgctcta aacaggcaga agaggagttc 1140
ctcgag                                                            1146

<210> 111
<211> 888
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 111
ctgcgcttgg ctgacttcgg cgtcctgcac cgcaacgaac tgagcggtgc gctgaccggc 60
ctgacccgtg tgcgtcgctt ccaacaagat gatgcacaca ttttctgcgc gatggagcag 120
atcgaggacg aaatcaaggg ttgtctggac tttctgcgta cggtttacag cgtttttggt 180
ttcagcttta aactgaatct gagcacgcgt cctgagaagt tcctgggtga catcgaagtg 240
tgggatcagg cagaaaagca attggagaat agcctgaatg agttcggcga gaaatgggag 300
ttgaactctg gcgacggcgc gttctacggt ccgaagatcg atattcagat taaagacgcc 360
atcggtcgtt accatcagtg cgctacgatt cagctggatt ttcagctgcc gattcgtttc 420
aatctgacct atgtttccca cgatggtgat gacaagaaac gcccggtcat cgtgcatcgc 480
gcgattctgg gtagcgttga gcgcatgatc gcgattttga ccgagaatta tggcggtaaa 540
tggccattct ggctgagccc gcgtcaagtt atggtggtcc cggttggtcc gacctgcgat 600
gagtatgcgc agaaggtccg tcaacagttc catgacgcca agtttatggc agatatcgac 660
ttggacccgg gttgtaccct gaacaaaaag atccgtaatg cgcagctggc ccaatacaac 720
tttatcctgg tggtaggtga aaaagagaag atttccggca cggtgaacat tcgcacccgt 780
gacaacaaag tccacggcga acgtaccatc agcgaaacta ttgaacgtct gcaacaactg 840
aaagagtttc gttctaaaca ggcagaagaa gagttttaat gactcgag              888

<210> 112
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 112
ggatcctctc gtctgtggat gacttctggc cattggcagc attatagcga aaacatgttc 60
agcttcgagg ttgagaaaga gctgtttgcc ctgaaaccga tgaattgtcc gggtcactgt 120
ctgatgttcg atcaccgtcc tcgttcttgg cgtgaactgc ctctgcgcct ggctgatttt 180
ggtgttctgc accgcaatga actgtcaggt gctctgactg gtctgactcg tgttcgtcgt 240
ttccagcagg atgatgccca cattttctgt gccatggagc aaattgaaga tgagatcaaa 300
gggtgcctgg attttctgcg taccgtgtat agcgtattcg gcttctcctt taaactgaat 360
ctgtctaccc gtccggaaaa atttctgggg gacatcgagg tctgggatca agcggaaaaa 420
caactggaga acagcctgaa cgaattcggc gaaaaatggg aactgaactc cggagatggt 480
gccttttatg gtcctaaaat tgatatccag atcaaagacg ccattgggcg ttatcatcag 540
tgtgccacca ttcagctgga ctttcaactg cctattcgct tcaatctgac ctatgtgagc 600
catgatgggg acgacaaaaa acgtcctgtg attgtacacc gtgccattct gggttctgtg 660
gagcgtatga ttgccattct gaccgagaac tatgggggca aatggccttt ttggctgtct 720
cctcgtcagg ttatggttgt gccggttggt ccaacttgtg atgagtatgc tcagaaagtt 780
cgccagcaat tccacgatgc caaattcatg gccgatatcg acctggaccc tggctgtacc 840
ctgaacaaaa aaatccgtaa tgcccagctg gcacagtata acttcatcct ggtagtgggc 900
gaaaaagaaa aaatctcggg gaccgtgaat attcgtaccc gtgataataa agttcatggg 960
gagcgtacca tttcagaaac catcgagcgc ctgcagcaac tgaaagagtt tcgtagtaaa 1020
caggccgaag aggaattcct cgag                                        1044

<210> 113
<211> 1302
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 113
ctgcagcgca tctacggcat ctcgttccca gaccctaaaa tgttgaaaga gtgggaaaag 60
ttccaagaag aggcgaaaaa ccgtgatcac cgcaagattg gtcgtgatca agagctgtat 120
ttcttccacg agctgtcccc gggttcgtgc ttcttcctgc cgaagggtgc gtacatctac 180
aatgctctga ttgagtttat tcgtagcgag tatcgtaagc gcggcttcca ggaagttgtc 240
acgccgaata tctttaacag ccgtctgtgg atgaccagcg gtcattggca gcactacagc 300
gagaatatgt ttagctttga agttgaaaaa gagctgttcg cgctgaagcc gatgaattgt 360
ccaggtcact gcctgatgtt cgaccaccgt ccgcgttctt ggcgtgaatt gccgctgcgc 420
ctggccgact tcggcgtgct gcatcgtaac gaactgagcg gtgcgctgac cggtctgacc 480
cgtgtgcgcc gttttcagca ggatgatgcg catatctttt gcgcaatgga gcaaatcgag 540
gacgagatca agggttgttt ggacttcctg cgcacggtgt atagcgtttt tggttttagc 600
tttaaactga acctgtctac ccgtccggag aaattcctgg gcgacattga ggtctgggac 660
caggcagaaa agcaactgga gaacagcttg aatgagtttg gcgagaaatg ggagctgaat 720
agcggcgacg gtgccttcta cggcccgaag attgatatcc agatcaaaga tgcgattggc 780
cgttatcacc agtgtgccac gatccagttg gactttcagc tgccgattcg ctttaatctg 840
acctacgtga gccatgatgg cgatgataag aaacgtccgg tcattgtcca tcgtgcgatt 900
ctgggtagcg ttgaacgcat gatcgctatt ctgaccgaaa actacggtgg taagtggccg 960
ttctggttgt ccccgcgtca ggtgatggtg gttccggttg gtcctacgtg cgacgagtat 1020
gcgcaaaaag ttcgccaaca gttccacgac gcaaagttta tggcagacat cgatctggac 1080
ccgggctgca ctttgaacaa gaagatccgt aatgcccaac tggcacaata caactttatt 1140
ctggtcgtgg gtgaaaaaga gaagattagc ggtactgtta acatccgtac ccgtgataac 1200
aaagtccacg gcgaacgcac catttccgaa acgattgagc gtctgcagca actgaaagaa 1260
ttccgcagca aacaagcgga agaagagttc taatgactcg ag                    1302

<210> 114
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 114
ggatccatcg ctattctgac cgaaaattat ggcggcaaat ggcctttttg gctgtctcct 60
cgtcaagtca tggttgttcc ggttggtccg acatgtgatg agtatgccca gaaagtccgt 120
cagcagtttc atgatgccaa attcatggcc gatatcgacc tggaccctgg ctgtacactg 180
aacaaaaaaa tccgtaacgc ccagctggct cagtataact tcatcctggt ggtgggtgag 240
aaagagaaaa tcagcggcac cgtcaacatt cgtacccgtg acaataaagt ccacggcgag 300
cgtacaattt cagagactat tgagcgcctg caacagctga aagaatttcg ctccaaacaa 360
gccgaagaag agttcctcga g                                           381

<210> 115
<211> 474
<212> PRT
<213> Homo sapiens

<400> 115
Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile Met Gly
 1               5                  10                  15      
Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly Pro Pro
            20                  25                  30          
Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly Gly Val
        35                  40                  45              
Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys Ile Ile
    50                  55                  60                  
Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu Thr Leu
65                  70                  75                  80  
Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu Asn Glu
                85                  90                  95      
Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro Leu Ile
            100                 105                 110         
Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile Lys Ala
        115                 120                 125             
Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys Ala Asp
    130                 135                 140                 
Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp Pro Lys
145                 150                 155                 160 
Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg Asp
                165                 170                 175     
His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu Leu
            180                 185                 190         
Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr Asn
        195                 200                 205             
Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe Gln
    210                 215                 220                 
Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr Ser
225                 230                 235                 240 
Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val Glu
                245                 250                 255     
Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys Leu
            260                 265                 270         
Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg Leu
        275                 280                 285             
Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu Thr
    290                 295                 300                 
Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile Phe
305                 310                 315                 320 
Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp Phe
                325                 330                 335     
Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn Leu
            340                 345                 350         
Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp Gln
        355                 360                 365             
Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys Trp
    370                 375                 380                 
Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp Ile
385                 390                 395                 400 
Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile Gln
                405                 410                 415     
Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser His
            420                 425                 430         
Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile Leu
        435                 440                 445             
Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly Gly
    450                 455                 460                 
Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln
465                 470                 


<210> 116
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 116
gaggaagctc aggcagtgta ttggcactct agtgctcaca taatgggtga agccatggaa 60
agagtctatg gtggatgttt atgctacggt ccgccaatag aaaatggatt ctattatgac 120
atgtacctcg aagaaggggg tgtgtctagc aatgatttct cttctctgga ggctttgtgt 180
aagaaaatca ttaaagaaaa acaagctttt gaaagactgg aagttaagaa agaaacttta 240
ctggcaatgt ttaagtacaa caagttcaaa tgccggatat tgaatgaaaa ggtgaatact 300
ccaactacca cagtctatag atgtggccct ttgatagatc tctgccgggg tcctcatgtt 360
agacacacgg gcaaaattaa ggctttaaaa atacacaaaa attcctccac gtactgggaa 420
ggcaaagcag atatggagac tctccagaga atttatggca tttcattccc agatcctaaa 480
atgttgaaag agtgggagaa gttccaagag gaagctaaaa accgagatca taggaaaatt 540
ggcagggacc aagaactata tttctttcat gaactcagcc ctggaagttg cttttttctg 600
ccaaaaggag cctacattta taatgcactt attgaattca ttaggagcga atataggaaa 660
agaggattcc aggaggtagt caccccaaac atcttcaaca gccgactctg gatgacctcg 720
ggccactggc agcactacag cgagaacatg ttctcctttg aggtggagaa ggagctgttt 780
gccctgaaac ccatgaactg cccaggacac tgccttatgt ttgatcatcg gccaaggtcc 840
tggcgagaac tgcctctgcg gctagctgat tttggggtac ttcataggaa cgagctgtct 900
ggagcactca caggactcac ccgggtacga agattccaac aggatgatgc tcacatattc 960
tgtgccatgg agcagattga agatgaaata aaaggttgtt tggattttct acgtacggta 1020
tatagcgtat ttggattttc ttttaaacta aacctttcta ctcgcccgga aaaattcctt 1080
ggagatatcg aagtatggga tcaagctgag aaacaacttg aaaacagtct gaatgaattt 1140
ggtgaaaagt gggagttaaa ctctggagat ggagctttct atggcccaaa gattgacata 1200
cagattaaag atgcgattgg gcggtaccac cagtgtgcaa ccatccagct ggatttccag 1260
ttgcccatca gatttaatct tacttatgta agccatgatg gtgatgataa gaaaaggcca 1320
gtgattgttc atcgagccat cttgggatca gtggaaagaa tgattgctat cctcacagaa 1380
aactatgggg gcaaatggcc cttttggctg tcccctcgcc ag                    1422

<210> 117
<211> 19
<212> PRT
<213> Mus musculus

<400> 117
Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe Ile Ala Glu Gly Ile Asp
 1               5                  10                  15      
Gln Thr Arg
            


<210> 118
<211> 20
<212> PRT
<213> Mus musculus

<400> 118
Gly Trp Phe Tyr Thr Leu Leu Val Leu Ala Thr Ala Leu Phe Gly Gln
 1               5                  10                  15      
Pro Pro Phe Lys
            20  


<210> 119
<211> 15
<212> PRT
<213> Mus musculus

<400> 119
Asn Val Ile Val Asn Gly Leu Ile Leu Ala Ser Asp Gly Gln Lys
 1               5                  10                  15  


<210> 120
<211> 438
<212> PRT
<213> Mus musculus

<400> 120
Met Ser Lys Arg Lys Lys Asn Tyr Pro Asp Pro Val Ser Ile Ile Asp
 1               5                  10                  15      
Lys Tyr Gly Ala Asp Ala Leu Arg Leu Tyr Leu Ile Asn Ser Pro Val
            20                  25                  30          
Val Arg Ala Glu Asn Leu Arg Phe Lys Glu Glu Gly Val Arg Asp Val
        35                  40                  45              
Leu Lys Asp Val Leu Leu Pro Trp Tyr Asn Ala Tyr Arg Phe Phe Ile
    50                  55                  60                  
Gln Asn Val Phe Arg Leu His Lys Glu Glu Glu Val Lys Phe Leu Tyr
65                  70                  75                  80  
Asn Glu His Thr Val Arg Glu Ser Pro Asn Ile Thr Asp Arg Trp Val
                85                  90                  95      
Leu Ser Phe Met Gln Ser Leu Leu Gly Phe Phe Glu Thr Glu Met Ala
            100                 105                 110         
Ala Tyr Arg Leu Tyr Thr Val Val Pro Arg Leu Val Lys Phe Val Asp
        115                 120                 125             
Ile Leu Thr Asn Trp Tyr Val Arg Met Asn Arg Arg Arg Leu Lys Gly
    130                 135                 140                 
Glu Ser Gly Val Glu Asp Cys Val Met Ala Leu Glu Thr Leu Phe Ser
145                 150                 155                 160 
Val Leu Leu Ser Leu Cys Arg Leu Met Ala Pro Tyr Thr Pro Phe Leu
                165                 170                 175     
Thr Glu Leu Met Tyr Gln Asn Leu Lys Leu Leu Ile Asp Pro Ala Ser
            180                 185                 190         
Leu Arg Asp Lys Asp Thr Leu Ser Ile His Tyr Leu Met Leu Pro Arg
        195                 200                 205             
Val Arg Glu Glu Leu Ile Asp Lys Lys Thr Glu Asn Ala Val Ser Arg
    210                 215                 220                 
Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp Arg Lys Thr
225                 230                 235                 240 
Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile His Gln Asp
                245                 250                 255     
Pro Glu Ala Leu Glu Asp Ile Arg Ser Leu Glu Lys Tyr Ile Ile Glu
            260                 265                 270         
Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys Asn Lys Tyr
        275                 280                 285             
Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu Gly Lys Arg
    290                 295                 300                 
Leu Lys Gly Ala Phe Lys Ala Val Met Met Ala Ile Lys Arg Leu Ser
305                 310                 315                 320 
Asn Glu Glu Leu Glu Arg Phe Gln Lys Ser Gly Ser Ile Val Val Glu
                325                 330                 335     
Gly His Glu Leu His Glu Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp
            340                 345                 350         
Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln
        355                 360                 365             
Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu
    370                 375                 380                 
Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys
385                 390                 395                 400 
Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Asn Ala Lys
                405                 410                 415     
Ser Glu Gly Arg Tyr Leu Asn Asn Val Ile Glu Ser His Thr Asp Phe
            420                 425                 430         
Val Phe Ala Thr Ile Lys
        435             


<210> 121
<211> 23
<212> PRT
<213> Mus musculus

<400> 121
Ala Pro Leu Lys Pro Tyr Pro Val Pro Thr Ser Asp Asn Ile Leu Ile
 1               5                  10                  15      
Gln Glu Gln Thr Gln Leu Lys
            20              


<210> 122
<211> 515
<212> PRT
<213> Mus musculus

<400> 122
Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe Ile Ala Glu Gly Ile Asp
 1               5                  10                  15      
Gln Thr Arg Gly Trp Phe Tyr Thr Leu Leu Val Leu Ala Thr Ala Leu
            20                  25                  30          
Phe Gly Gln Pro Pro Phe Lys Asn Val Ile Val Asn Gly Leu Ile Leu
        35                  40                  45              
Ala Ser Asp Gly Gln Lys Met Ser Lys Arg Lys Lys Asn Tyr Pro Asp
    50                  55                  60                  
Pro Val Ser Ile Ile Asp Lys Tyr Gly Ala Asp Ala Leu Arg Leu Tyr
65                  70                  75                  80  
Leu Ile Asn Ser Pro Val Val Arg Ala Glu Asn Leu Arg Phe Lys Glu
                85                  90                  95      
Glu Gly Val Arg Asp Val Leu Lys Asp Val Leu Leu Pro Trp Tyr Asn
            100                 105                 110         
Ala Tyr Arg Phe Phe Ile Gln Asn Val Phe Arg Leu His Lys Glu Glu
        115                 120                 125             
Glu Val Lys Phe Leu Tyr Asn Glu His Thr Val Arg Glu Ser Pro Asn
    130                 135                 140                 
Ile Thr Asp Arg Trp Val Leu Ser Phe Met Gln Ser Leu Leu Gly Phe
145                 150                 155                 160 
Phe Glu Thr Glu Met Ala Ala Tyr Arg Leu Tyr Thr Val Val Pro Arg
                165                 170                 175     
Leu Val Lys Phe Val Asp Ile Leu Thr Asn Trp Tyr Val Arg Met Asn
            180                 185                 190         
Arg Arg Arg Leu Lys Gly Glu Ser Gly Val Glu Asp Cys Val Met Ala
        195                 200                 205             
Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu Met Ala
    210                 215                 220                 
Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys Leu
225                 230                 235                 240 
Leu Ile Asp Pro Ala Ser Leu Arg Asp Lys Asp Thr Leu Ser Ile His
                245                 250                 255     
Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys Lys Thr
            260                 265                 270         
Glu Asn Ala Val Ser Arg Met Gln Ser Val Ile Glu Leu Gly Arg Val
        275                 280                 285             
Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile
    290                 295                 300                 
Val Val Ile His Gln Asp Pro Glu Ala Leu Glu Asp Ile Arg Ser Leu
305                 310                 315                 320 
Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser
                325                 330                 335     
Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His
            340                 345                 350         
Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Met
        355                 360                 365             
Ala Ile Lys Arg Leu Ser Asn Glu Glu Leu Glu Arg Phe Gln Lys Ser
    370                 375                 380                 
Gly Ser Ile Val Val Glu Gly His Glu Leu His Glu Glu Asp Ile Arg
385                 390                 395                 400 
Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu
                405                 410                 415     
Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp
            420                 425                 430         
Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile
        435                 440                 445             
Gln Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr
    450                 455                 460                 
Val Tyr Tyr Asn Ala Lys Ser Glu Gly Arg Tyr Leu Asn Asn Val Ile
465                 470                 475                 480 
Glu Ser His Thr Asp Phe Val Phe Ala Thr Ile Lys Ala Pro Leu Lys
                485                 490                 495     
Pro Tyr Pro Val Pro Thr Ser Asp Asn Ile Leu Ile Gln Glu Gln Thr
            500                 505                 510         
Gln Leu Lys
        515 


<210> 123
<211> 495
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 123
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser
            20                  25                  30          
Ala His Ile Met Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu
        35                  40                  45              
Cys Tyr Gly Pro Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu
    50                  55                  60                  
Glu Glu Gly Gly Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu
65                  70                  75                  80  
Cys Lys Lys Ile Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val
                85                  90                  95      
Lys Lys Glu Thr Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys
            100                 105                 110         
Arg Ile Leu Asn Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg
        115                 120                 125             
Cys Gly Pro Leu Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr
    130                 135                 140                 
Gly Lys Ile Lys Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp
145                 150                 155                 160 
Glu Gly Lys Ala Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser
                165                 170                 175     
Phe Pro Asp Pro Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu
            180                 185                 190         
Ala Lys Asn Arg Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr
        195                 200                 205             
Phe Phe His Glu Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly
    210                 215                 220                 
Ala Tyr Ile Tyr Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg
225                 230                 235                 240 
Lys Arg Gly Phe Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg
                245                 250                 255     
Leu Trp Met Thr Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe
            260                 265                 270         
Ser Phe Glu Val Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys
        275                 280                 285             
Pro Gly His Cys Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu
    290                 295                 300                 
Leu Pro Leu Arg Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu
305                 310                 315                 320 
Ser Gly Ala Leu Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp
                325                 330                 335     
Asp Ala His Ile Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys
            340                 345                 350         
Gly Cys Leu Asp Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser
        355                 360                 365             
Phe Lys Leu Asn Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile
    370                 375                 380                 
Glu Val Trp Asp Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu
385                 390                 395                 400 
Phe Gly Glu Lys Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly
                405                 410                 415     
Pro Lys Ile Asp Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln
            420                 425                 430         
Cys Ala Thr Ile Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu
        435                 440                 445             
Thr Tyr Val Ser His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val
    450                 455                 460                 
His Arg Ala Ile Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr
465                 470                 475                 480 
Glu Asn Tyr Gly Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln
                485                 490                 495 


<210> 124
<211> 495
<212> PRT
<213> Artificial Sequence

<220> 
<223> Threonyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 124
Met Glu Glu Ala Gln Ala Val Tyr Trp His Ser Ser Ala His Ile Met
 1               5                  10                  15      
Gly Glu Ala Met Glu Arg Val Tyr Gly Gly Cys Leu Cys Tyr Gly Pro
            20                  25                  30          
Pro Ile Glu Asn Gly Phe Tyr Tyr Asp Met Tyr Leu Glu Glu Gly Gly
        35                  40                  45              
Val Ser Ser Asn Asp Phe Ser Ser Leu Glu Ala Leu Cys Lys Lys Ile
    50                  55                  60                  
Ile Lys Glu Lys Gln Ala Phe Glu Arg Leu Glu Val Lys Lys Glu Thr
65                  70                  75                  80  
Leu Leu Ala Met Phe Lys Tyr Asn Lys Phe Lys Cys Arg Ile Leu Asn
                85                  90                  95      
Glu Lys Val Asn Thr Pro Thr Thr Thr Val Tyr Arg Cys Gly Pro Leu
            100                 105                 110         
Ile Asp Leu Cys Arg Gly Pro His Val Arg His Thr Gly Lys Ile Lys
        115                 120                 125             
Ala Leu Lys Ile His Lys Asn Ser Ser Thr Tyr Trp Glu Gly Lys Ala
    130                 135                 140                 
Asp Met Glu Thr Leu Gln Arg Ile Tyr Gly Ile Ser Phe Pro Asp Pro
145                 150                 155                 160 
Lys Met Leu Lys Glu Trp Glu Lys Phe Gln Glu Glu Ala Lys Asn Arg
                165                 170                 175     
Asp His Arg Lys Ile Gly Arg Asp Gln Glu Leu Tyr Phe Phe His Glu
            180                 185                 190         
Leu Ser Pro Gly Ser Cys Phe Phe Leu Pro Lys Gly Ala Tyr Ile Tyr
        195                 200                 205             
Asn Ala Leu Ile Glu Phe Ile Arg Ser Glu Tyr Arg Lys Arg Gly Phe
    210                 215                 220                 
Gln Glu Val Val Thr Pro Asn Ile Phe Asn Ser Arg Leu Trp Met Thr
225                 230                 235                 240 
Ser Gly His Trp Gln His Tyr Ser Glu Asn Met Phe Ser Phe Glu Val
                245                 250                 255     
Glu Lys Glu Leu Phe Ala Leu Lys Pro Met Asn Cys Pro Gly His Cys
            260                 265                 270         
Leu Met Phe Asp His Arg Pro Arg Ser Trp Arg Glu Leu Pro Leu Arg
        275                 280                 285             
Leu Ala Asp Phe Gly Val Leu His Arg Asn Glu Leu Ser Gly Ala Leu
    290                 295                 300                 
Thr Gly Leu Thr Arg Val Arg Arg Phe Gln Gln Asp Asp Ala His Ile
305                 310                 315                 320 
Phe Cys Ala Met Glu Gln Ile Glu Asp Glu Ile Lys Gly Cys Leu Asp
                325                 330                 335     
Phe Leu Arg Thr Val Tyr Ser Val Phe Gly Phe Ser Phe Lys Leu Asn
            340                 345                 350         
Leu Ser Thr Arg Pro Glu Lys Phe Leu Gly Asp Ile Glu Val Trp Asp
        355                 360                 365             
Gln Ala Glu Lys Gln Leu Glu Asn Ser Leu Asn Glu Phe Gly Glu Lys
    370                 375                 380                 
Trp Glu Leu Asn Ser Gly Asp Gly Ala Phe Tyr Gly Pro Lys Ile Asp
385                 390                 395                 400 
Ile Gln Ile Lys Asp Ala Ile Gly Arg Tyr His Gln Cys Ala Thr Ile
                405                 410                 415     
Gln Leu Asp Phe Gln Leu Pro Ile Arg Phe Asn Leu Thr Tyr Val Ser
            420                 425                 430         
His Asp Gly Asp Asp Lys Lys Arg Pro Val Ile Val His Arg Ala Ile
        435                 440                 445             
Leu Gly Ser Val Glu Arg Met Ile Ala Ile Leu Thr Glu Asn Tyr Gly
    450                 455                 460                 
Gly Lys Trp Pro Phe Trp Leu Ser Pro Arg Gln Gly Lys Pro Ile Pro
465                 470                 475                 480 
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                485                 490                 495 


<210> 125
<211> 1434
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized threonyl tRNA synthetase
      polynucleotide

<400> 125
gaggaagcac aagcggtata ctggcacagc agcgcgcaca tcatgggtga ggcgatggag 60
cgtgtgtacg gtggctgcct gtgctacggt ccgccgattg agaatggttt ctattatgat 120
atgtacctgg aagagggtgg cgtgtctagc aatgatttct ccagcttgga ggcgctgtgt 180
aagaagatta tcaaagagaa gcaggccttc gagcgcctgg aagttaagaa agagactctg 240
ctggcaatgt ttaagtacaa caagtttaag tgtcgcattt tgaatgaaaa agtgaacacc 300
ccaaccacga cggtgtatcg ctgtggtccg ttgatcgact tgtgtcgtgg ccctcacgtc 360
cgtcacaccg gtaaaatcaa ggcactgaaa attcacaaga acagcagcac ctactgggag 420
ggcaaggcag acatggaaac tctgcaacgt atttacggca tctcgttccc ggatccgaaa 480
atgctgaaag aatgggagaa atttcaggaa gaggcgaaga atcgtgacca tcgcaagatt 540
ggccgtgacc aagaactgta cttcttccac gagctgtctc cgggttcctg cttcttcctg 600
cctaagggtg catacattta caacgctctg attgagttta ttcgcagcga gtatcgtaaa 660
cgtggctttc aagaggttgt taccccgaac attttcaata gccgtctgtg gatgaccagc 720
ggtcattggc aacattatag cgagaacatg ttttcttttg aggtcgagaa agagctgttt 780
gccctgaaac caatgaactg cccgggtcac tgtctgatgt tcgatcaccg tccgcgcagc 840
tggcgtgaac tgccgttgcg tttggcggat ttcggcgtgt tgcaccgcaa cgaactgagc 900
ggtgcgctga ccggtctgac ccgcgtccgc cgctttcagc aggatgacgc gcatatcttt 960
tgcgctatgg agcagatcga ggacgaaatc aaaggttgct tggatttcct gcgcaccgtg 1020
tatagcgttt ttggtttcag ctttaagctg aacctgagca cgcgtccgga aaagttcctg 1080
ggtgacatcg aagtttggga ccaggccgaa aaacaactgg agaactccct gaatgaattt 1140
ggcgaaaagt gggaactgaa tagcggtgat ggtgccttct acggcccgaa aatcgacatc 1200
cagatcaaag acgctatcgg tcgttatcac caatgcgcga cgattcagct ggattttcag 1260
ctgccgatcc gtttcaatct gacctatgtg agccatgacg gcgatgacaa gaaacgtccg 1320
gttattgtcc atcgtgcgat tctgggcagc gtcgaacgta tgattgcaat cctgacggag 1380
aattacggtg gcaaatggcc gttctggctg tccccgcgtc aataatgact cgag       1434

<210> 126
<211> 2067
<212> DNA
<213> Homo sapiens

<400> 126
atgtttgagg agaaggccag cagtccttca gggaagatgg gaggcgagga gaagccgatt 60
ggtgctggtg aagagaagca aaaggaagga ggcaaaaaga agaacaaaga aggatctgga 120
gatggaggtc gagctgagtt gaatccttgg cctgaatata tttacacacg tcttgagatg 180
tataatatac taaaagcaga acatgattcc attctggcag aaaaggcaga aaaagatagc 240
aagccaatta aagtcacttt gcctgatggt aaacaggttg atgcggaatc ttggaaaact 300
acaccatatc aaattgcctg tggaattagt caaggcctgg ccgacaacac cgttattgct 360
aaagtaaata atgttgtgtg ggacctggac cgccctctgg aagaagattg taccttggag 420
cttctcaagt ttgaggatga ggaagctcag gcagtgtatt ggcactctag tgctcacata 480
atgggtgaag ccatggaaag agtctatggt ggatgtttat gctacggtcc gccaatagaa 540
aatggattct attatgacat gtacctcgaa gaagggggtg tgtctagcaa tgatttctct 600
tctctggagg ctttgtgtaa gaaaatcatt aaagaaaaac aagcttttga aagactggaa 660
gttaagaaag aaactttact ggcaatgttt aagtacaaca agttcaaatg ccggatattg 720
aatgaaaagg tgaatactcc aactaccaca gtctatagat gtggcccttt gatagatctc 780
tgccggggtc ctcatgttag acacacgggc aaaattaagg ctttaaaaat acacaaaaat 840
tcctccacgt actgggaagg caaagcagat atggagactc tccagagaat ttatggcatt 900
tcattcccag atcctaaaat gttgaaagag tgggagaagt tccaagagga agctaaaaac 960
cgagatcata ggaaaattgg cagggaccaa gaactatatt tctttcatga actcagccct 1020
ggaagttgct tttttctgcc aaaaggagcc tacatttata atgcacttat tgaattcatt 1080
aggagcgaat ataggaaaag aggattccag gaggtagtca ccccaaacat cttcaacagc 1140
cgactctgga tgacctcggg ccactggcag cactacagcg agaacatgtt ctcctttgag 1200
gtggagaagg agctgtttgc cctgaaaccc atgaactgcc caggacactg ccttatgttt 1260
gatcatcggc caaggtcctg gcgagaactg cctctgcggc tagctgattt tggggtactt 1320
cataggaacg agctgtctgg agcactcaca ggactcaccc gggtacgaag attccaacag 1380
gatgatgctc acatattctg tgccatggag cagattgaag atgaaataaa aggttgtttg 1440
gattttctac gtacggtata tagcgtattt ggattttctt ttaaactaaa cctttctact 1500
cgcccggaaa aattccttgg agatatcgaa gtatgggatc aagctgagaa acaacttgaa 1560
aacagtctga atgaatttgg tgaaaagtgg gagttaaact ctggagatgg agctttctat 1620
ggcccaaaga ttgacataca gattaaagat gcgattgggc ggtaccacca gtgtgcaacc 1680
atccagctgg atttccagtt gcccatcaga tttaatctta cttatgtaag gcccttttgg 1740
ctgtcccctc gccaggtaat ggtagttcca gtgggaccaa cctgtgatga atatgcccaa 1800
aaggtacgac aacaattcca cgatgccaaa ttcatggcag acattgatct ggatccaggc 1860
tgtacattga ataaaaagat tcgaaatgca cagttagcac agtataactt cattttagtt 1920
gttggtgaaa aagagaaaat cagtggcact gttaatatcc gcacaagaga caataaggtc 1980
cacggggaac gcaccatttc tgaaactatc gagcggctac agcagctcaa agagttccgc 2040
agcaaacagg cagaagaaga attttaa                                     2067
