
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF ISOLEUCYL-tRNA SYNTHETASES
  

<130> 120161.453PC

<140> PCT                 
<141> 2011-04-27  

<150> US 61/328,570       
<151> 2010-04-27  

<150> US 61/328,539       
<151> 2010-04-27  

<150> US 61/328,534       
<151> 2010-04-27  

<160> 50

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 1201
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Asn Lys Met Leu Gln Gln Val Pro Glu Asn Ile Asn Phe Pro
 1               5                  10                  15      
Ala Glu Glu Glu Lys Ile Leu Glu Phe Trp Thr Glu Phe Asn Cys Phe
            20                  25                  30          
Gln Glu Cys Leu Lys Gln Ser Lys His Lys Pro Lys Phe Thr Phe Tyr
        35                  40                  45              
Asp Gly Pro Pro Phe Ala Thr Gly Leu Pro His Tyr Gly His Ile Leu
    50                  55                  60                  
Ala Gly Thr Ile Lys Asp Ile Val Thr Arg Tyr Ala His Gln Ser Gly
65                  70                  75                  80  
Phe His Val Asp Arg Arg Phe Gly Trp Asp Cys His Gly Leu Pro Val
                85                  90                  95      
Glu Tyr Glu Ile Asp Lys Thr Leu Gly Ile Arg Gly Pro Glu Asp Val
            100                 105                 110         
Ala Lys Met Gly Ile Thr Glu Tyr Asn Asn Gln Cys Arg Ala Ile Val
        115                 120                 125             
Met Arg Tyr Ser Ala Glu Trp Lys Ser Thr Val Ser Arg Leu Gly Arg
    130                 135                 140                 
Trp Ile Asp Phe Asp Asn Asp Tyr Lys Thr Leu Tyr Pro Gln Phe Met
145                 150                 155                 160 
Glu Ser Val Trp Trp Val Phe Lys Gln Leu Tyr Asp Lys Gly Leu Val
                165                 170                 175     
Tyr Arg Gly Val Lys Val Met Pro Phe Ser Thr Ala Cys Asn Thr Pro
            180                 185                 190         
Leu Ser Asn Phe Glu Ser His Gln Asn Tyr Lys Asp Val Gln Asp Pro
        195                 200                 205             
Ser Val Phe Val Thr Phe Pro Leu Glu Glu Asp Glu Thr Val Ser Leu
    210                 215                 220                 
Val Ala Trp Thr Thr Thr Pro Trp Thr Leu Pro Ser Asn Leu Ala Val
225                 230                 235                 240 
Cys Val Asn Pro Glu Met Gln Tyr Val Lys Ile Lys Asp Val Ala Arg
                245                 250                 255     
Gly Arg Leu Leu Ile Leu Met Glu Ala Arg Leu Ser Ala Leu Tyr Lys
            260                 265                 270         
Leu Glu Ser Asp Tyr Glu Ile Leu Glu Arg Phe Pro Gly Ala Tyr Leu
        275                 280                 285             
Lys Gly Lys Lys Tyr Arg Pro Leu Phe Asp Tyr Phe Leu Lys Cys Lys
    290                 295                 300                 
Glu Asn Gly Ala Phe Thr Val Leu Val Asp Asn Tyr Val Lys Glu Glu
305                 310                 315                 320 
Glu Gly Thr Gly Val Val His Gln Ala Pro Tyr Phe Gly Ala Glu Asp
                325                 330                 335     
Tyr Arg Val Cys Met Asp Phe Asn Ile Ile Arg Lys Asp Ser Leu Pro
            340                 345                 350         
Val Cys Pro Val Asp Ala Ser Gly Cys Phe Thr Thr Glu Val Thr Asp
        355                 360                 365             
Phe Ala Gly Gln Tyr Val Lys Asp Ala Asp Lys Ser Ile Ile Arg Thr
    370                 375                 380                 
Leu Lys Glu Gln Gly Arg Leu Leu Val Ala Thr Thr Phe Thr His Ser
385                 390                 395                 400 
Tyr Pro Phe Cys Trp Arg Ser Asp Thr Pro Leu Ile Tyr Lys Ala Val
                405                 410                 415     
Pro Ser Trp Phe Val Arg Val Glu Asn Met Val Asp Gln Leu Leu Arg
            420                 425                 430         
Asn Asn Asp Leu Cys Tyr Trp Val Pro Glu Leu Val Arg Glu Lys Arg
        435                 440                 445             
Phe Gly Asn Trp Leu Lys Asp Ala Arg Asp Trp Thr Ile Ser Arg Asn
    450                 455                 460                 
Arg Tyr Trp Gly Thr Pro Ile Pro Leu Trp Val Ser Asp Asp Phe Glu
465                 470                 475                 480 
Glu Val Val Cys Ile Gly Ser Val Ala Glu Leu Glu Glu Leu Ser Gly
                485                 490                 495     
Ala Lys Ile Ser Asp Leu His Arg Glu Arg Phe Tyr Thr Leu Leu Val
            500                 505                 510         
Leu Ala Thr Ala Leu Phe Gly Gln Pro Pro Phe Lys Asn Val Ile Val
        515                 520                 525             
Asn Gly Leu Val Leu Ala Ser Asp Gly Gln Lys Met Ser Lys Arg Lys
    530                 535                 540                 
Lys Asn Tyr Pro Asp Pro Val Ser Ile Ile Gln Lys Tyr Gly Ala Asp
545                 550                 555                 560 
Ala Leu Arg Leu Tyr Leu Ile Asn Ser Pro Val Val Arg Ala Glu Asn
                565                 570                 575     
Leu Arg Phe Lys Glu Glu Gly Val Arg Asp Val Leu Lys Asp Val Leu
            580                 585                 590         
Leu Pro Trp Tyr Asn Ala Tyr Arg Phe Leu Ile Gln Asn Val Leu Arg
        595                 600                 605             
Leu Gln Lys Glu Glu Glu Ile Glu Phe Leu Tyr Asn Glu Asn Thr Val
    610                 615                 620                 
Arg Glu Ser Pro Asn Ile Thr Asp Arg Trp Ile Leu Ser Phe Met Gln
625                 630                 635                 640 
Ser Leu Ile Gly Phe Phe Glu Thr Glu Met Ala Ala Tyr Arg Leu Tyr
                645                 650                 655     
Thr Val Val Pro Arg Leu Val Lys Phe Val Asp Ile Leu Thr Asn Trp
            660                 665                 670         
Tyr Val Arg Met Asn Arg Arg Arg Leu Lys Gly Glu Asn Gly Met Glu
        675                 680                 685             
Asp Cys Val Met Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu
    690                 695                 700                 
Cys Arg Leu Met Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr
705                 710                 715                 720 
Gln Asn Leu Lys Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys Asp
                725                 730                 735     
Thr Leu Ser Ile His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu
            740                 745                 750         
Ile Asp Lys Lys Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val Ile
        755                 760                 765             
Glu Leu Gly Arg Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr
    770                 775                 780                 
Pro Leu Lys Glu Ile Val Val Ile His Gln Asp Pro Glu Ala Leu Lys
785                 790                 795                 800 
Asp Ile Lys Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg
                805                 810                 815     
Lys Val Thr Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg
            820                 825                 830         
Ala Glu Pro Asp His Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe
        835                 840                 845             
Lys Ala Val Met Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu
    850                 855                 860                 
Gln Phe Gln Lys Thr Gly Thr Ile Val Val Glu Gly His Glu Leu His
865                 870                 875                 880 
Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly
                885                 890                 895     
Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu
            900                 905                 910         
Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu
        915                 920                 925             
Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys Cys Asn Leu Val Pro
    930                 935                 940                 
Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala Lys Ser Glu Gly Thr Tyr
945                 950                 955                 960 
Leu Asn Ser Val Ile Glu Ser His Thr Glu Phe Ile Phe Thr Thr Ile
                965                 970                 975     
Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser Pro Ser Asp Lys Val Leu
            980                 985                 990         
Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu
        995                 1000                1005            
Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu
    1010                1015                1020                
Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly Gly Val Leu Leu Leu Glu
1025                1030                1035               1040 
Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu Leu Lys Leu Lys Ser Val
                1045                1050                1055    
Val Thr Ser Ile Phe Gly Val Lys Asn Thr Glu Leu Ala Val Phe His
            1060                1065                1070        
Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu Leu Ser Leu Ser Gly
        1075                1080                1085            
Lys Thr Leu Cys Val Thr Ala Gly Ser Ala Pro Ser Leu Ile Asn Ser
    1090                1095                1100                
Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn Leu Gln Leu Leu Asn Ala
1105                1110                1115               1120 
Lys Pro Gln Glu Cys Leu Met Gly Thr Val Gly Thr Leu Leu Leu Glu
                1125                1130                1135    
Asn Pro Leu Gly Gln Asn Gly Leu Thr His Gln Gly Leu Leu Tyr Glu
            1140                1145                1150        
Ala Ala Lys Val Phe Gly Leu Arg Ser Arg Lys Leu Lys Leu Phe Leu
        1155                1160                1165            
Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu Asp Ile Pro Val Lys Thr
    1170                1175                1180                
Leu Asn Met Lys Thr Val Tyr Val Ser Val Leu Pro Thr Thr Ala Asp
1185                1190                1195               1200 
Phe
    


<210> 13
<211> 3606
<212> DNA
<213> Homo sapiens

<400> 13
atgagcaaca aaatgcttca acaagttcca gaaaacataa attttcctgc tgaagaagag 60
aaaatcttgg agttttggac tgaatttaat tgttttcagg aatgcttaaa gcaatcaaaa 120
cataaaccaa aatttacctt ctatgatggt cctccttttg caactggact gcctcactat 180
ggacatatac ttgcgggtac aattaaagat atagttacaa gatatgctca ccagagtggg 240
tttcatgttg acagaagatt tggatgggat tgccatggct tacctgtgga atatgaaatt 300
gataagacac tgggaatcag aggaccagag gatgtggcca aaatggggat tacagagtat 360
aacaatcagt gccgagcaat tgtgatgaga tattctgctg agtggaagtc tactgttagc 420
agacttggcc gatggattga ctttgacaat gactataaaa ctctgtatcc acaattcatg 480
gaatcagtct ggtgggtctt caaacaactc tatgataaag gccttgttta tagaggtgtg 540
aaagtcatgc ccttctctac ggcatgtaac actccacttt ccaacttcga gtcacaccag 600
aattataagg atgttcaaga tccttcagta tttgtaactt tccctttgga agaagatgaa 660
actgtatctt tagttgcttg gacaaccact ccctggactc tacctagtaa ccttgctgtg 720
tgtgttaatc cagaaatgca atatgtgaaa attaaagatg ttgccagagg acgattactc 780
attttaatgg aagccagatt gtcagccctc tataaattgg agagtgacta tgagatcctt 840
gaaagatttc ctggtgccta tcttaaaggc aagaagtaca ggcccctgtt tgactatttc 900
ctgaagtgta aagagaatgg cgctttcact gtgcttgttg acaactatgt gaaggaagaa 960
gaaggcacag gggttgtcca ccaagctcct tacttcggtg ctgaggacta tcgggtctgt 1020
atggacttta acattattcg gaaagactca ctccctgttt gccctgtgga tgcttcaggc 1080
tgcttcacaa cggaggtgac agatttcgca ggacagtatg tgaaggatgc tgacaaaagt 1140
atcatcagga ctttgaagga acaaggccga cttctggttg ccaccacctt cactcacagc 1200
tacccttttt gctggagatc agacactcct ctaatttaca aagcagtgcc cagctggttt 1260
gtgcgagtgg agaacatggt ggaccagctc ctaaggaaca atgacctgtg ctactgggtc 1320
ccagagttgg tacgagaaaa acgatttgga aattggctga aagatgcacg tgactggaca 1380
atttccagaa acagatactg gggcaccccc atcccactgt gggtcagcga tgactttgag 1440
gaggtggtat gcattgggtc agtggcggaa cttgaagaac tgtcaggagc aaagatctca 1500
gatctccaca gagagaggtt ttataccctg ctggtgctgg ccacggccct ctttggacaa 1560
ccgcctttca agaacgtaat tgtgaatggg cttgtcctgg caagtgatgg ccaaaaaatg 1620
agcaaacgga aaaagaatta tccagatcca gtttccatca tccagaagta tggtgctgat 1680
gccctcagat tatatctgat taactcccct gtggtgagag cagaaaacct ccgctttaaa 1740
gaagagggtg tgcgggacgt ccttaaggat gtactgctcc catggtacaa tgcctatcgc 1800
ttcttaatcc agaacgttct gaggctccag aaggaggaag aaatagaatt tctctacaat 1860
gagaacacgg ttagagaaag ccccaacatt acagaccggt ggatcctgtc cttcatgcag 1920
tctctcattg gcttctttga gactgaaatg gcagcttata ggctttatac tgtggtgcct 1980
cgcctggtca agtttgtaga tattctgacc aattggtatg ttagaatgaa ccgcagaaga 2040
ttaaagggtg aaaatgggat ggaggattgt gtcatggccc tagaaacctt gtttagtgtt 2100
ctgctttctc tttgcagact tatggctccc tacacacctt ttctcactga attgatgtac 2160
cagaatctaa aggtgctgat tgaccctgtt tctgttcagg acaaggacac actcagcatt 2220
cactacctca tgctgccccg tgttcgagaa gaattgattg acaagaaaac agagagtgca 2280
gtatctcaga tgcagtctgt gattgaactt ggaagagtga tcagagaccg aaaaactatt 2340
cccataaagt atcctttgaa agaaattgtg gttatccatc aagatccaga agctcttaaa 2400
gatatcaagt ctttggagaa gtatatcatt gaggaactca atgttcgaaa agttacactg 2460
tctacagata aaaacaagta tggcattcgg ctaagggcag aaccagatca catggtcctg 2520
gggaagcgtc tgaagggagc ctttaaggca gtgatgacgt ccatcaagca gttgagcagt 2580
gaggagctgg agcagttcca gaagactggg accattgttg tggaaggcca tgaattgcac 2640
gatgaagaca tccgcctcat gtacaccttt gatcaggcca caggtgggac tgcgcaattt 2700
gaagcacact cagatgctca ggctttggtc ctcttagatg tcactcctga ccagtcaatg 2760
gtagatgaag gaatggctcg ggaagtcatc aatcgcatac agaaacttcg caaaaagtgc 2820
aatctggttc caactgatga aatcacagtg tactataaag caaagtctga aggaacatat 2880
ctgaatagtg ttattgaaag ccacacagag ttcatattta ccaccataaa ggctcccttg 2940
aaaccatatc cagtttctcc atcggataaa gtccttattc aagaaaaaac acagttgaag 3000
ggatctgaac tggaaattac actcaccaga ggatcttccc ttcctggtcc tgcttgtgca 3060
tatgtcaatc ttaacatttg tgcaaatggc agtgaacaag gtggagtatt gctcctggaa 3120
aatccaaaag gtgacaatag gttggacctt ttaaagctga agagtgttgt cactagcatt 3180
tttggtgtga aaaatacaga gctggctgtc ttccatgatg aaacagaaat acaaaaccaa 3240
actgacttac tgagtcttag tggaaaaaca ctttgtgtga ctgcaggatc ggctccctct 3300
ctgatcaaca gttctagtac tcttctttgt cagtatatca acctacagct cctgaatgca 3360
aagccacaag agtgtttaat ggggacagtg ggcactctcc tgcttgaaaa cccacttggg 3420
cagaatggac tcacccacca aggtcttctg tatgaagcag ccaaggtgtt tggccttcgg 3480
agcaggaagc taaagctgtt tctgaatgag acccaaacgc aggaaattac agaagacatc 3540
cccgtgaaga ctttgaatat gaagactgtg tatgtttctg tgttaccaac aacagcagac 3600
ttctag                                                            3606

<210> 14
<211> 717
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Asn Lys Met Leu Gln Gln Val Pro Glu Asn Ile Asn Phe Pro
 1               5                  10                  15      
Ala Glu Glu Glu Lys Ile Leu Glu Phe Trp Thr Glu Phe Asn Cys Phe
            20                  25                  30          
Gln Glu Cys Leu Lys Gln Ser Lys His Lys Pro Lys Phe Thr Phe Tyr
        35                  40                  45              
Asp Gly Pro Pro Phe Ala Thr Gly Leu Pro His Tyr Gly His Ile Leu
    50                  55                  60                  
Ala Gly Thr Ile Lys Asp Ile Val Thr Arg Tyr Ala His Gln Ser Gly
65                  70                  75                  80  
Phe His Val Asp Arg Arg Phe Gly Trp Asp Cys His Gly Leu Pro Val
                85                  90                  95      
Glu Tyr Glu Ile Asp Lys Thr Leu Gly Ile Arg Gly Pro Glu Asp Val
            100                 105                 110         
Ala Lys Met Gly Ile Thr Glu Tyr Asn Asn Gln Cys Arg Ala Ile Val
        115                 120                 125             
Met Arg Tyr Ser Ala Glu Trp Lys Ser Thr Val Ser Arg Leu Gly Arg
    130                 135                 140                 
Trp Ile Asp Phe Asp Asn Asp Tyr Lys Thr Leu Tyr Pro Gln Phe Met
145                 150                 155                 160 
Glu Ser Val Trp Trp Val Phe Lys Gln Leu Tyr Asp Lys Gly Leu Val
                165                 170                 175     
Tyr Arg Gly Val Lys Val Met Pro Phe Ser Thr Ala Cys Asn Thr Pro
            180                 185                 190         
Leu Ser Asn Phe Glu Ser His Gln Asn Tyr Lys Asp Val Gln Asp Pro
        195                 200                 205             
Ser Val Phe Val Thr Phe Pro Leu Glu Glu Asp Glu Thr Val Ser Leu
    210                 215                 220                 
Val Ala Trp Thr Thr Thr Pro Trp Thr Leu Pro Ser Asn Leu Ala Val
225                 230                 235                 240 
Cys Val Asn Pro Glu Met Gln Tyr Val Lys Ile Lys Asp Val Ala Arg
                245                 250                 255     
Gly Arg Leu Leu Ile Leu Met Glu Ala Arg Leu Ser Ala Leu Tyr Lys
            260                 265                 270         
Leu Glu Ser Asp Tyr Glu Ile Leu Glu Arg Phe Pro Gly Ala Tyr Leu
        275                 280                 285             
Lys Gly Lys Lys Tyr Arg Pro Leu Phe Asp Tyr Phe Leu Lys Cys Lys
    290                 295                 300                 
Glu Asn Gly Ala Phe Thr Val Leu Val Asp Asn Tyr Val Lys Glu Glu
305                 310                 315                 320 
Glu Gly Thr Gly Val Val His Gln Ala Pro Tyr Phe Gly Ala Glu Asp
                325                 330                 335     
Tyr Arg Val Cys Met Asp Phe Asn Ile Ile Arg Lys Asp Ser Leu Pro
            340                 345                 350         
Val Cys Pro Val Asp Ala Ser Gly Cys Phe Thr Thr Glu Val Thr Asp
        355                 360                 365             
Phe Ala Gly Gln Tyr Val Lys Asp Ala Asp Lys Ser Ile Ile Arg Thr
    370                 375                 380                 
Leu Lys Glu Gln Gly Arg Leu Leu Val Ala Thr Thr Phe Thr His Ser
385                 390                 395                 400 
Tyr Pro Phe Cys Trp Arg Ser Asp Thr Pro Leu Ile Tyr Lys Ala Val
                405                 410                 415     
Pro Ser Trp Phe Val Arg Val Glu Asn Met Val Asp Gln Leu Leu Arg
            420                 425                 430         
Asn Asn Asp Leu Cys Tyr Trp Val Pro Glu Leu Val Arg Glu Lys Arg
        435                 440                 445             
Phe Gly Asn Trp Leu Lys Asp Ala Arg Asp Trp Thr Ile Ser Arg Asn
    450                 455                 460                 
Arg Tyr Trp Gly Thr Pro Ile Pro Leu Trp Val Ser Asp Asp Phe Glu
465                 470                 475                 480 
Glu Val Val Cys Ile Gly Ser Val Ala Glu Leu Glu Glu Leu Ser Gly
                485                 490                 495     
Ala Lys Ile Ser Asp Leu His Arg Glu Ser Val Asp His Leu Thr Ile
            500                 505                 510         
Pro Ser Arg Cys Gly Lys Gly Ser Leu His Arg Ile Ser Glu Val Phe
        515                 520                 525             
Asp Cys Trp Phe Glu Ser Gly Ser Met Pro Tyr Ala Gln Val His Tyr
    530                 535                 540                 
Pro Phe Glu Asn Lys Arg Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe
545                 550                 555                 560 
Ile Ala Glu Gly Ile Asp Gln Thr Arg Gly Trp Phe Tyr Thr Leu Leu
                565                 570                 575     
Val Leu Ala Thr Ala Leu Phe Gly Gln Pro Pro Phe Lys Asn Val Ile
            580                 585                 590         
Val Asn Gly Leu Val Leu Ala Ser Asp Gly Gln Lys Met Ser Lys Arg
        595                 600                 605             
Lys Lys Asn Tyr Pro Asp Pro Val Ser Ile Ile Gln Lys Tyr Gly Ala
    610                 615                 620                 
Asp Ala Leu Arg Leu Tyr Leu Ile Asn Ser Pro Val Val Arg Ala Glu
625                 630                 635                 640 
Asn Leu Arg Phe Lys Glu Glu Gly Val Arg Asp Val Leu Lys Asp Val
                645                 650                 655     
Leu Leu Pro Trp Tyr Asn Ala Tyr Arg Phe Leu Ile Gln Asn Val Leu
            660                 665                 670         
Arg Leu Gln Lys Glu Glu Glu Ile Glu Phe Leu Tyr Asn Glu Asn Thr
        675                 680                 685             
Val Arg Glu Ser Pro Asn Ile Thr Asp Arg Trp Ile Leu Ser Phe Met
    690                 695                 700                 
Gln Ser Leu Ile Gly Phe Phe Glu Thr Glu Met Ala Gly
705                 710                 715         


<210> 15
<211> 2154
<212> DNA
<213> Homo sapiens

<400> 15
atgagcaaca aaatgcttca acaagttcca gaaaacataa attttcctgc tgaagaagag 60
aaaatcttgg agttttggac tgaatttaat tgttttcagg aatgcttaaa gcaatcaaaa 120
cataaaccaa aatttacctt ctatgatggt cctccttttg caactggact gcctcactat 180
ggacatatac ttgcgggtac aattaaagat atagttacaa gatatgctca ccagagtggg 240
tttcatgttg acagaagatt tggatgggat tgccatggct tacctgtgga atatgaaatt 300
gataagacac tgggaatcag aggaccagag gatgtggcca aaatggggat tacagagtat 360
aacaatcagt gccgagcaat tgtgatgaga tattctgctg agtggaagtc tactgttagc 420
agacttggcc gatggattga ctttgacaat gactataaaa ctctgtatcc acaattcatg 480
gaatcagtct ggtgggtctt caaacaactc tatgataaag gccttgttta tagaggtgtg 540
aaagtcatgc ccttctctac ggcatgtaac actccacttt ccaacttcga gtcacaccag 600
aattataagg atgttcaaga tccttcagta tttgtaactt tccctttgga agaagatgaa 660
actgtatctt tagttgcttg gacaaccact ccctggactc tacctagtaa ccttgctgtg 720
tgtgttaatc cagaaatgca atatgtgaaa attaaagatg ttgccagagg acgattactc 780
attttaatgg aagccagatt gtcagccctc tataaattgg agagtgacta tgagatcctt 840
gaaagatttc ctggtgccta tcttaaaggc aagaagtaca ggcccctgtt tgactatttc 900
ctgaagtgta aagagaatgg cgctttcact gtgcttgttg acaactatgt gaaggaagaa 960
gaaggcacag gggttgtcca ccaagctcct tacttcggtg ctgaggacta tcgggtctgt 1020
atggacttta acattattcg gaaagactca ctccctgttt gccctgtgga tgcttcaggc 1080
tgcttcacaa cggaggtgac agatttcgca ggacagtatg tgaaggatgc tgacaaaagt 1140
atcatcagga ctttgaagga acaaggccga cttctggttg ccaccacctt cactcacagc 1200
tacccttttt gctggagatc agacactcct ctaatttaca aagcagtgcc cagctggttt 1260
gtgcgagtgg agaacatggt ggaccagctc ctaaggaaca atgacctgtg ctactgggtc 1320
ccagagttgg tacgagaaaa acgatttgga aattggctga aagatgcacg tgactggaca 1380
atttccagaa acagatactg gggcaccccc atcccactgt gggtcagcga tgactttgag 1440
gaggtggtat gcattgggtc agtggcggaa cttgaagaac tgtcaggagc aaagatctca 1500
gatctccaca gagagagtgt tgaccacctg accattcctt cacgctgtgg gaagggatcc 1560
ttgcaccgca tctctgaagt gtttgactgt tggtttgaga gtggcagcat gccctatgct 1620
caggttcatt acccgtttga aaacaagagg gagtttgagg atgcttttcc tgcagatttc 1680
attgccgagg gcatcgacca aaccagagga tggttttata ccctgctggt gctggccacg 1740
gccctctttg gacaaccgcc tttcaagaac gtaattgtga atgggcttgt cctggcaagt 1800
gatggccaaa aaatgagcaa acggaaaaag aattatccag atccagtttc catcatccag 1860
aagtatggtg ctgatgccct cagattatat ctgattaact cccctgtggt gagagcagaa 1920
aacctccgct ttaaagaaga gggtgtgcgg gacgtcctta aggatgtact gctcccatgg 1980
tacaatgcct atcgcttctt aatccagaac gttctgaggc tccagaagga ggaagaaata 2040
gaatttctct acaatgagaa cacggttaga gaaagcccca acattacaga ccggtggatc 2100
ctgtccttca tgcagtctct cattggcttc tttgagactg aaatggcagg gtga       2154

<210> 16
<211> 50
<212> DNA
<213> Homo sapiens

<400> 16
agatctcaga tctccacaga gagaggtttt ataccctgct ggtgctggcc            50

<210> 17
<211> 16
<212> PRT
<213> Homo sapiens

<400> 17
Ile Ser Asp Leu His Arg Glu Arg Phe Tyr Thr Leu Leu Val Leu Ala
 1               5                  10                  15      


<210> 18
<211> 50
<212> DNA
<213> Homo sapiens

<400> 18
ggcttctttg agactgaaat ggcagggtga aaatgggatg gaggattgtg            50

<210> 19
<211> 9
<212> PRT
<213> Homo sapiens

<400> 19
Gly Phe Phe Glu Thr Glu Met Ala Gly
 1               5                  


<210> 20
<211> 452
<212> PRT
<213> Homo sapiens

<400> 20
Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala Val Ser Gln Met Gln
 1               5                  10                  15      
Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp Arg Lys Thr Ile Pro
            20                  25                  30          
Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile His Gln Asp Pro Glu
        35                  40                  45              
Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu
    50                  55                  60                  
Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile
65                  70                  75                  80  
Arg Leu Arg Ala Glu Pro Asp His Met Val Leu Gly Lys Arg Leu Lys
                85                  90                  95      
Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys Gln Leu Ser Ser Glu
            100                 105                 110         
Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile Val Val Glu Gly His
        115                 120                 125             
Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala
    130                 135                 140                 
Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln Ala Leu
145                 150                 155                 160 
Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu Gly Met
                165                 170                 175     
Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys Cys Asn
            180                 185                 190         
Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala Lys Ser Glu
        195                 200                 205             
Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu Phe Ile Phe
    210                 215                 220                 
Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser Pro Ser Asp
225                 230                 235                 240 
Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser Glu Leu Glu
                245                 250                 255     
Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala Cys Ala Tyr
            260                 265                 270         
Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly Gly Val Leu
        275                 280                 285             
Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu Leu Lys Leu
    290                 295                 300                 
Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr Glu Leu Ala
305                 310                 315                 320 
Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu Leu Ser
                325                 330                 335     
Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala Pro Ser Leu
            340                 345                 350         
Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn Leu Gln Leu
        355                 360                 365             
Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val Gly Thr Leu
    370                 375                 380                 
Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His Gln Gly Leu
385                 390                 395                 400 
Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg Lys Leu Lys
                405                 410                 415     
Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu Asp Ile Pro
            420                 425                 430         
Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val Leu Pro Thr
        435                 440                 445             
Thr Ala Asp Phe
    450         


<210> 21
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 21
gaagaattga ttgacaagaa aacagagagt gcagtatctc agatgcagtc tgtgattgaa 60
cttggaagag tgatcagaga ccgaaaaact attcccataa agtatccttt gaaagaaatt 120
gtggttatcc atcaagatcc agaagctctt aaagatatca agtctttgga gaagtatatc 180
attgaggaac tcaatgttcg aaaagttaca ctgtctacag ataaaaacaa gtatggcatt 240
cggctaaggg cagaaccaga tcacatggtc ctggggaagc gtctgaaggg agcctttaag 300
gcagtgatga cgtccatcaa gcagttgagc agtgaggagc tggagcagtt ccagaagact 360
gggaccattg ttgtggaagg ccatgaattg cacgatgaag acatccgcct catgtacacc 420
tttgatcagg ccacaggtgg gactgcgcaa tttgaagcac actcagatgc tcaggctttg 480
gtcctcttag atgtcactcc tgaccagtca atggtagatg aaggaatggc tcgggaagtc 540
atcaatcgca tacagaaact tcgcaaaaag tgcaatctgg ttccaactga tgaaatcaca 600
gtgtactata aagcaaagtc tgaaggaaca tatctgaata gtgttattga aagccacaca 660
gagttcatat ttaccaccat aaaggctccc ttgaaaccat atccagtttc tccatcggat 720
aaagtcctta ttcaagaaaa aacacagttg aagggatctg aactggaaat tacactcacc 780
agaggatctt cccttcctgg tcctgcttgt gcatatgtca atcttaacat ttgtgcaaat 840
ggcagtgaac aaggtggagt attgctcctg gaaaatccaa aaggtgacaa taggttggac 900
cttttaaagc tgaagagtgt tgtcactagc atttttggtg tgaaaaatac agagctggct 960
gtcttccatg atgaaacaga aatacaaaac caaactgact tactgagtct tagtggaaaa 1020
acactttgtg tgactgcagg atcggctccc tctctgatca acagttctag tactcttctt 1080
tgtcagtata tcaacctaca gctcctgaat gcaaagccac aagagtgttt aatggggaca 1140
gtgggcactc tcctgcttga aaacccactt gggcagaatg gactcaccca ccaaggtctt 1200
ctgtatgaag cagccaaggt gtttggcctt cggagcagga agctaaagct gtttctgaat 1260
gagacccaaa cgcaggaaat tacagaagac atccccgtga agactttgaa tatgaagact 1320
gtgtatgttt ctgtgttacc aacaacagca gacttctag                        1359

<210> 22
<211> 17
<212> PRT
<213> Mus musculus

<400> 22
Ser Gly Ser Ile Val Val Glu Gly His Glu Leu His Glu Glu Asp Ile
 1               5                  10                  15      
Arg
    


<210> 23
<211> 182
<212> PRT
<213> Mus musculus

<400> 23
Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu
 1               5                  10                  15      
Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp
            20                  25                  30          
Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile
        35                  40                  45              
Gln Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr
    50                  55                  60                  
Val Tyr Tyr Asn Ala Lys Ser Glu Gly Arg Tyr Leu Asn Asn Val Ile
65                  70                  75                  80  
Glu Ser His Thr Asp Phe Val Phe Ala Thr Ile Lys Ala Pro Leu Lys
                85                  90                  95      
Pro Tyr Pro Val Pro Thr Ser Asp Asn Ile Leu Ile Gln Glu Gln Thr
            100                 105                 110         
Gln Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Lys Gly Ser Cys
        115                 120                 125             
Val Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn
    130                 135                 140                 
Gly Thr Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp
145                 150                 155                 160 
Asn Gln Leu Asn Leu Val Lys Leu Lys Thr Val Val Thr Ser Val Phe
                165                 170                 175     
Gly Val Lys Asn Ala Lys
            180         


<210> 24
<211> 22
<212> PRT
<213> Mus musculus

<400> 24
Leu Ser Val Phe His Gly Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu
 1               5                  10                  15      
Leu Ser Leu Ser Gly Arg
            20          


<210> 25
<211> 221
<212> PRT
<213> Mus musculus

<400> 25
Ser Gly Ser Ile Val Val Glu Gly His Glu Leu His Glu Glu Asp Ile
 1               5                  10                  15      
Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe
            20                  25                  30          
Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro
        35                  40                  45              
Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg
    50                  55                  60                  
Ile Gln Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile
65                  70                  75                  80  
Thr Val Tyr Tyr Asn Ala Lys Ser Glu Gly Arg Tyr Leu Asn Asn Val
                85                  90                  95      
Ile Glu Ser His Thr Asp Phe Val Phe Ala Thr Ile Lys Ala Pro Leu
            100                 105                 110         
Lys Pro Tyr Pro Val Pro Thr Ser Asp Asn Ile Leu Ile Gln Glu Gln
        115                 120                 125             
Thr Gln Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Lys Gly Ser
    130                 135                 140                 
Cys Val Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala
145                 150                 155                 160 
Asn Gly Thr Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly
                165                 170                 175     
Asp Asn Gln Leu Asn Leu Val Lys Leu Lys Thr Val Val Thr Ser Val
            180                 185                 190         
Phe Gly Val Lys Asn Ala Lys Leu Ser Val Phe His Gly Glu Thr Glu
        195                 200                 205             
Ile Gln Asn Gln Thr Asp Leu Leu Ser Leu Ser Gly Arg
    210                 215                 220     


<210> 26
<211> 551
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Thr Arg Leu Glu Lys Ala Pro Thr Leu Gln Thr Gly Gly Ser
 1               5                  10                  15      
Cys Pro Ser Cys Ser Leu Ser Leu Ala Ser Leu Arg Leu Lys Trp Gln
            20                  25                  30          
Gly Glu Asn Gly Met Glu Asp Cys Val Met Ala Leu Glu Thr Leu Phe
        35                  40                  45              
Ser Val Leu Leu Ser Leu Cys Arg Leu Met Ala Pro Tyr Thr Pro Phe
    50                  55                  60                  
Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys Val Leu Ile Asp Pro Val
65                  70                  75                  80  
Ser Val Gln Asp Lys Asp Thr Leu Ser Ile His Tyr Leu Met Leu Pro
                85                  90                  95      
Arg Val Arg Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala Val Ser
            100                 105                 110         
Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp Arg Lys
        115                 120                 125             
Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile His Gln
    130                 135                 140                 
Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr Ile Ile
145                 150                 155                 160 
Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys Asn Lys
                165                 170                 175     
Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu Gly Lys
            180                 185                 190         
Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys Gln Leu
        195                 200                 205             
Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile Val Val
    210                 215                 220                 
Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe
225                 230                 235                 240 
Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala
                245                 250                 255     
Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp
            260                 265                 270         
Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys
        275                 280                 285             
Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala
    290                 295                 300                 
Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu
305                 310                 315                 320 
Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser
                325                 330                 335     
Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser
            340                 345                 350         
Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala
        355                 360                 365             
Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly
    370                 375                 380                 
Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu
385                 390                 395                 400 
Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr
                405                 410                 415     
Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp
            420                 425                 430         
Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala
        435                 440                 445             
Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn
    450                 455                 460                 
Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val
465                 470                 475                 480 
Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His
                485                 490                 495     
Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg
            500                 505                 510         
Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu
        515                 520                 525             
Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val
    530                 535                 540                 
Leu Pro Thr Thr Ala Asp Phe
545                 550     


<210> 27
<211> 1656
<212> DNA
<213> Homo sapiens

<400> 27
atgagaacac ggttagagaa agccccaaca ttacagaccg gtggatcctg tccttcatgc 60
agtctctcat tggcttcttt gagactgaaa tggcagggtg aaaatgggat ggaggattgt 120
gtcatggccc tagaaacctt gtttagtgtt ctgctttctc tttgcagact tatggctccc 180
tacacacctt ttctcactga attgatgtac cagaatctaa aggtgctgat tgaccctgtt 240
tctgttcagg acaaggacac actcagcatt cactacctca tgctgccccg tgttcgagaa 300
gaattgattg acaagaaaac agagagtgca gtatctcaga tgcagtctgt gattgaactt 360
ggaagagtga tcagagaccg aaaaactatt cccataaagt atcctttgaa agaaattgtg 420
gttatccatc aagatccaga agctcttaaa gatatcaagt ctttggagaa gtatatcatt 480
gaggaactca atgttcgaaa agttacactg tctacagata aaaacaagta tggcattcgg 540
ctaagggcag aaccagatca catggtcctg gggaagcgtc tgaagggagc ctttaaggca 600
gtgatgacgt ccatcaagca gttgagcagt gaggagctgg agcagttcca gaagactggg 660
accattgttg tggaaggcca tgaattgcac gatgaagaca tccgcctcat gtacaccttt 720
gatcaggcca caggtgggac tgcgcaattt gaagcacact cagatgctca ggctttggtc 780
ctcttagatg tcactcctga ccagtcaatg gtagatgaag gaatggctcg ggaagtcatc 840
aatcgcatac agaaacttcg caaaaagtgc aatctggttc caactgatga aatcacagtg 900
tactataaag caaagtctga aggaacatat ctgaatagtg ttattgaaag ccacacagag 960
ttcatattta ccaccataaa ggctcccttg aaaccatatc cagtttctcc atcggataaa 1020
gtccttattc aagaaaaaac acagttgaag ggatctgaac tggaaattac actcaccaga 1080
ggatcttccc ttcctggtcc tgcttgtgca tatgtcaatc ttaacatttg tgcaaatggc 1140
agtgaacaag gtggagtatt gctcctggaa aatccaaaag gtgacaatag gttggacctt 1200
ttaaagctga agagtgttgt cactagcatt tttggtgtga aaaatacaga gctggctgtc 1260
ttccatgatg aaacagaaat acaaaaccaa actgacttac tgagtcttag tggaaaaaca 1320
ctttgtgtga ctgcaggatc ggctccctct ctgatcaaca gttctagtac tcttctttgt 1380
cagtatatca acctacagct cctgaatgca aagccacaag agtgtttaat ggggacagtg 1440
ggcactctcc tgcttgaaaa cccacttggg cagaatggac tcacccacca aggtcttctg 1500
tatgaagcag ccaaggtgtt tggccttcgg agcaggaagc taaagctgtt tctgaatgag 1560
acccaaacgc aggaaattac agaagacatc cccgtgaaga ctttgaatat gaagactgtg 1620
tatgtttctg tgttaccaac aacagcagac ttctag                           1656

<210> 28
<211> 50
<212> DNA
<213> Homo sapiens

<400> 28
ggcttctttg agactgaaat ggcagggtga aaatgggatg gaggattgtg            50

<210> 29
<211> 16
<212> PRT
<213> Homo sapiens

<400> 29
Ala Ser Leu Arg Leu Lys Trp Gln Gly Glu Asn Gly Met Glu Asp Cys
 1               5                  10                  15      


<210> 30
<211> 520
<212> PRT
<213> Homo sapiens

<400> 30
Lys Gly Glu Asn Gly Met Glu Asp Cys Val Met Ala Leu Glu Thr Leu
 1               5                  10                  15      
Phe Ser Val Leu Leu Ser Leu Cys Arg Leu Met Ala Pro Tyr Thr Pro
            20                  25                  30          
Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys Val Leu Ile Asp Pro
        35                  40                  45              
Val Ser Val Gln Asp Lys Asp Thr Leu Ser Ile His Tyr Leu Met Leu
    50                  55                  60                  
Pro Arg Val Arg Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala Val
65                  70                  75                  80  
Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp Arg
                85                  90                  95      
Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile His
            100                 105                 110         
Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr Ile
        115                 120                 125             
Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys Asn
    130                 135                 140                 
Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu Gly
145                 150                 155                 160 
Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys Gln
                165                 170                 175     
Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile Val
            180                 185                 190         
Val Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr
        195                 200                 205             
Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp
    210                 215                 220                 
Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val
225                 230                 235                 240 
Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg
                245                 250                 255     
Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys
            260                 265                 270         
Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr
        275                 280                 285             
Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val
    290                 295                 300                 
Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly
305                 310                 315                 320 
Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro
                325                 330                 335     
Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln
            340                 345                 350         
Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp
        355                 360                 365             
Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn
    370                 375                 380                 
Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr
385                 390                 395                 400 
Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser
                405                 410                 415     
Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile
            420                 425                 430         
Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr
        435                 440                 445             
Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr
    450                 455                 460                 
His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser
465                 470                 475                 480 
Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr
                485                 490                 495     
Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser
            500                 505                 510         
Val Leu Pro Thr Thr Ala Asp Phe
        515                 520 


<210> 31
<211> 1563
<212> DNA
<213> Homo sapiens

<400> 31
aagggtgaaa atgggatgga ggattgtgtc atggccctag aaaccttgtt tagtgttctg 60
ctttctcttt gcagacttat ggctccctac acaccttttc tcactgaatt gatgtaccag 120
aatctaaagg tgctgattga ccctgtttct gttcaggaca aggacacact cagcattcac 180
tacctcatgc tgccccgtgt tcgagaagaa ttgattgaca agaaaacaga gagtgcagta 240
tctcagatgc agtctgtgat tgaacttgga agagtgatca gagaccgaaa aactattccc 300
ataaagtatc ctttgaaaga aattgtggtt atccatcaag atccagaagc tcttaaagat 360
atcaagtctt tggagaagta tatcattgag gaactcaatg ttcgaaaagt tacactgtct 420
acagataaaa acaagtatgg cattcggcta agggcagaac cagatcacat ggtcctgggg 480
aagcgtctga agggagcctt taaggcagtg atgacgtcca tcaagcagtt gagcagtgag 540
gagctggagc agttccagaa gactgggacc attgttgtgg aaggccatga attgcacgat 600
gaagacatcc gcctcatgta cacctttgat caggccacag gtgggactgc gcaatttgaa 660
gcacactcag atgctcaggc tttggtcctc ttagatgtca ctcctgacca gtcaatggta 720
gatgaaggaa tggctcggga agtcatcaat cgcatacaga aacttcgcaa aaagtgcaat 780
ctggttccaa ctgatgaaat cacagtgtac tataaagcaa agtctgaagg aacatatctg 840
aatagtgtta ttgaaagcca cacagagttc atatttacca ccataaaggc tcccttgaaa 900
ccatatccag tttctccatc ggataaagtc cttattcaag aaaaaacaca gttgaaggga 960
tctgaactgg aaattacact caccagagga tcttcccttc ctggtcctgc ttgtgcatat 1020
gtcaatctta acatttgtgc aaatggcagt gaacaaggtg gagtattgct cctggaaaat 1080
ccaaaaggtg acaataggtt ggacctttta aagctgaaga gtgttgtcac tagcattttt 1140
ggtgtgaaaa atacagagct ggctgtcttc catgatgaaa cagaaataca aaaccaaact 1200
gacttactga gtcttagtgg aaaaacactt tgtgtgactg caggatcggc tccctctctg 1260
atcaacagtt ctagtactct tctttgtcag tatatcaacc tacagctcct gaatgcaaag 1320
ccacaagagt gtttaatggg gacagtgggc actctcctgc ttgaaaaccc acttgggcag 1380
aatggactca cccaccaagg tcttctgtat gaagcagcca aggtgtttgg ccttcggagc 1440
aggaagctaa agctgtttct gaatgagacc caaacgcagg aaattacaga agacatcccc 1500
gtgaagactt tgaatatgaa gactgtgtat gtttctgtgt taccaacaac agcagacttc 1560
tag                                                               1563

<210> 32
<211> 325
<212> PRT
<213> Homo sapiens

<400> 32
His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp Gln
 1               5                  10                  15      
Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln Ala
            20                  25                  30          
Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu Gly
        35                  40                  45              
Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys Cys
    50                  55                  60                  
Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala Lys Ser
65                  70                  75                  80  
Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu Phe Ile
                85                  90                  95      
Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser Pro Ser
            100                 105                 110         
Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser Glu Leu
        115                 120                 125             
Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala Cys Ala
    130                 135                 140                 
Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly Gly Val
145                 150                 155                 160 
Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu Leu Lys
                165                 170                 175     
Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr Glu Leu
            180                 185                 190         
Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu Leu
        195                 200                 205             
Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala Pro Ser
    210                 215                 220                 
Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn Leu Gln
225                 230                 235                 240 
Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val Gly Thr
                245                 250                 255     
Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His Gln Gly
            260                 265                 270         
Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg Lys Leu
        275                 280                 285             
Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu Asp Ile
    290                 295                 300                 
Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val Leu Pro
305                 310                 315                 320 
Thr Thr Ala Asp Phe
                325 


<210> 33
<211> 978
<212> DNA
<213> Homo sapiens

<400> 33
catgaattgc acgatgaaga catccgcctc atgtacacct ttgatcaggc cacaggtggg 60
actgcgcaat ttgaagcaca ctcagatgct caggctttgg tcctcttaga tgtcactcct 120
gaccagtcaa tggtagatga aggaatggct cgggaagtca tcaatcgcat acagaaactt 180
cgcaaaaagt gcaatctggt tccaactgat gaaatcacag tgtactataa agcaaagtct 240
gaaggaacat atctgaatag tgttattgaa agccacacag agttcatatt taccaccata 300
aaggctccct tgaaaccata tccagtttct ccatcggata aagtccttat tcaagaaaaa 360
acacagttga agggatctga actggaaatt acactcacca gaggatcttc ccttcctggt 420
cctgcttgtg catatgtcaa tcttaacatt tgtgcaaatg gcagtgaaca aggtggagta 480
ttgctcctgg aaaatccaaa aggtgacaat aggttggacc ttttaaagct gaagagtgtt 540
gtcactagca tttttggtgt gaaaaataca gagctggctg tcttccatga tgaaacagaa 600
atacaaaacc aaactgactt actgagtctt agtggaaaaa cactttgtgt gactgcagga 660
tcggctccct ctctgatcaa cagttctagt actcttcttt gtcagtatat caacctacag 720
ctcctgaatg caaagccaca agagtgttta atggggacag tgggcactct cctgcttgaa 780
aacccacttg ggcagaatgg actcacccac caaggtcttc tgtatgaagc agccaaggtg 840
tttggccttc ggagcaggaa gctaaagctg tttctgaatg agacccaaac gcaggaaatt 900
acagaagaca tccccgtgaa gactttgaat atgaagactg tgtatgtttc tgtgttacca 960
acaacagcag acttctag                                               978

<210> 34
<211> 473
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      N-terminal 6xHis (DNA2.0) affinity tag

<400> 34
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala
            20                  25                  30          
Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp
        35                  40                  45              
Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile
    50                  55                  60                  
His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr
65                  70                  75                  80  
Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys
                85                  90                  95      
Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu
            100                 105                 110         
Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys
        115                 120                 125             
Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile
    130                 135                 140                 
Val Val Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr
145                 150                 155                 160 
Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser
                165                 170                 175     
Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met
            180                 185                 190         
Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu
        195                 200                 205             
Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr
    210                 215                 220                 
Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His
225                 230                 235                 240 
Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro
                245                 250                 255     
Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys
            260                 265                 270         
Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly
        275                 280                 285             
Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu
    290                 295                 300                 
Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu
305                 310                 315                 320 
Asp Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys
                325                 330                 335     
Asn Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln
            340                 345                 350         
Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly
        355                 360                 365             
Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr
    370                 375                 380                 
Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly
385                 390                 395                 400 
Thr Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu
                405                 410                 415     
Thr His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg
            420                 425                 430         
Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile
        435                 440                 445             
Thr Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val
    450                 455                 460                 
Ser Val Leu Pro Thr Thr Ala Asp Phe
465                 470             


<210> 35
<211> 473
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      C-terminal 6xHis (DNA2.0) affinity tag

<400> 35
Met Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala Val Ser Gln Met
 1               5                  10                  15      
Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp Arg Lys Thr Ile
            20                  25                  30          
Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile His Gln Asp Pro
        35                  40                  45              
Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr Ile Ile Glu Glu
    50                  55                  60                  
Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys Asn Lys Tyr Gly
65                  70                  75                  80  
Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu Gly Lys Arg Leu
                85                  90                  95      
Lys Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys Gln Leu Ser Ser
            100                 105                 110         
Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile Val Val Glu Gly
        115                 120                 125             
His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp Gln
    130                 135                 140                 
Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln Ala
145                 150                 155                 160 
Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu Gly
                165                 170                 175     
Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys Cys
            180                 185                 190         
Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala Lys Ser
        195                 200                 205             
Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu Phe Ile
    210                 215                 220                 
Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser Pro Ser
225                 230                 235                 240 
Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser Glu Leu
                245                 250                 255     
Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala Cys Ala
            260                 265                 270         
Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly Gly Val
        275                 280                 285             
Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu Leu Lys
    290                 295                 300                 
Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr Glu Leu
305                 310                 315                 320 
Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu Leu
                325                 330                 335     
Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala Pro Ser
            340                 345                 350         
Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn Leu Gln
        355                 360                 365             
Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val Gly Thr
    370                 375                 380                 
Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His Gln Gly
385                 390                 395                 400 
Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg Lys Leu
                405                 410                 415     
Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu Asp Ile
            420                 425                 430         
Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val Leu Pro
        435                 440                 445             
Thr Thr Ala Asp Phe Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
    450                 455                 460                 
Asp Ser Thr His His His His His His
465                 470             


<210> 36
<211> 545
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      N-terminal 6xHis  affinity tag

<400> 36
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Lys Gly Glu Asn Gly Met Glu Asp Cys
            20                  25                  30          
Val Met Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg
        35                  40                  45              
Leu Met Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn
    50                  55                  60                  
Leu Lys Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu
65                  70                  75                  80  
Ser Ile His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp
                85                  90                  95      
Lys Lys Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu
            100                 105                 110         
Gly Arg Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu
        115                 120                 125             
Lys Glu Ile Val Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile
    130                 135                 140                 
Lys Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val
145                 150                 155                 160 
Thr Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu
                165                 170                 175     
Pro Asp His Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala
            180                 185                 190         
Val Met Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe
        195                 200                 205             
Gln Lys Thr Gly Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu
    210                 215                 220                 
Asp Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala
225                 230                 235                 240 
Gln Phe Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val
                245                 250                 255     
Thr Pro Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile
            260                 265                 270         
Asn Arg Ile Gln Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp
        275                 280                 285             
Glu Ile Thr Val Tyr Tyr Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn
    290                 295                 300                 
Ser Val Ile Glu Ser His Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala
305                 310                 315                 320 
Pro Leu Lys Pro Tyr Pro Val Ser Pro Ser Asp Lys Val Leu Ile Gln
                325                 330                 335     
Glu Lys Thr Gln Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg
            340                 345                 350         
Gly Ser Ser Leu Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile
        355                 360                 365             
Cys Ala Asn Gly Ser Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro
    370                 375                 380                 
Lys Gly Asp Asn Arg Leu Asp Leu Leu Lys Leu Lys Ser Val Val Thr
385                 390                 395                 400 
Ser Ile Phe Gly Val Lys Asn Thr Glu Leu Ala Val Phe His Asp Glu
                405                 410                 415     
Thr Glu Ile Gln Asn Gln Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr
            420                 425                 430         
Leu Cys Val Thr Ala Gly Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser
        435                 440                 445             
Thr Leu Leu Cys Gln Tyr Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro
    450                 455                 460                 
Gln Glu Cys Leu Met Gly Thr Val Gly Thr Leu Leu Leu Glu Asn Pro
465                 470                 475                 480 
Leu Gly Gln Asn Gly Leu Thr His Gln Gly Leu Leu Tyr Glu Ala Ala
                485                 490                 495     
Lys Val Phe Gly Leu Arg Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu
            500                 505                 510         
Thr Gln Thr Gln Glu Ile Thr Glu Asp Ile Pro Val Lys Thr Leu Asn
        515                 520                 525             
Met Lys Thr Val Tyr Val Ser Val Leu Pro Thr Thr Ala Asp Phe Leu
    530                 535                 540                 
Glu
545 


<210> 37
<211> 545
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      C-terminal 6xHis  affinity tag

<400> 37
Met Gly Ser Lys Gly Glu Asn Gly Met Glu Asp Cys Val Met Ala Leu
 1               5                  10                  15      
Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu Met Ala Pro
            20                  25                  30          
Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys Val Leu
        35                  40                  45              
Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser Ile His Tyr
    50                  55                  60                  
Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys Lys Thr Glu
65                  70                  75                  80  
Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile
                85                  90                  95      
Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val
            100                 105                 110         
Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu
        115                 120                 125             
Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr
    130                 135                 140                 
Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met
145                 150                 155                 160 
Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser
                165                 170                 175     
Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly
            180                 185                 190         
Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu
        195                 200                 205             
Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala
    210                 215                 220                 
His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln
225                 230                 235                 240 
Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln
                245                 250                 255     
Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val
            260                 265                 270         
Tyr Tyr Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu
        275                 280                 285             
Ser His Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro
    290                 295                 300                 
Tyr Pro Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln
305                 310                 315                 320 
Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu
                325                 330                 335     
Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly
            340                 345                 350         
Ser Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn
        355                 360                 365             
Arg Leu Asp Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly
    370                 375                 380                 
Val Lys Asn Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln
385                 390                 395                 400 
Asn Gln Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr
                405                 410                 415     
Ala Gly Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys
            420                 425                 430         
Gln Tyr Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu
        435                 440                 445             
Met Gly Thr Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn
    450                 455                 460                 
Gly Leu Thr His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly
465                 470                 475                 480 
Leu Arg Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln
                485                 490                 495     
Glu Ile Thr Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val
            500                 505                 510         
Tyr Val Ser Val Leu Pro Thr Thr Ala Asp Phe Leu Glu Gly Lys Pro
        515                 520                 525             
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
    530                 535                 540                 
His
545 


<210> 38
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      N-terminal 6xHis  affinity tag

<400> 38
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr His Glu Leu His Asp Glu Asp Ile Arg Leu Met
            20                  25                  30          
Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His
        35                  40                  45              
Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser
    50                  55                  60                  
Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys
65                  70                  75                  80  
Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr
                85                  90                  95      
Tyr Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser
            100                 105                 110         
His Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr
        115                 120                 125             
Pro Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu
    130                 135                 140                 
Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro
145                 150                 155                 160 
Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser
                165                 170                 175     
Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg
            180                 185                 190         
Leu Asp Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val
        195                 200                 205             
Lys Asn Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn
    210                 215                 220                 
Gln Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala
225                 230                 235                 240 
Gly Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln
                245                 250                 255     
Tyr Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met
            260                 265                 270         
Gly Thr Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly
        275                 280                 285             
Leu Thr His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu
    290                 295                 300                 
Arg Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu
305                 310                 315                 320 
Ile Thr Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr
                325                 330                 335     
Val Ser Val Leu Pro Thr Thr Ala Asp Phe
            340                 345     


<210> 39
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      C-terminal 6xHis  affinity tag

<400> 39
Met His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp
 1               5                  10                  15      
Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln
            20                  25                  30          
Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu
        35                  40                  45              
Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys
    50                  55                  60                  
Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala Lys
65                  70                  75                  80  
Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu Phe
                85                  90                  95      
Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser Pro
            100                 105                 110         
Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser Glu
        115                 120                 125             
Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala Cys
    130                 135                 140                 
Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly Gly
145                 150                 155                 160 
Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu Leu
                165                 170                 175     
Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr Glu
            180                 185                 190         
Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu
        195                 200                 205             
Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala Pro
    210                 215                 220                 
Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn Leu
225                 230                 235                 240 
Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val Gly
                245                 250                 255     
Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His Gln
            260                 265                 270         
Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg Lys
        275                 280                 285             
Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu Asp
    290                 295                 300                 
Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val Leu
305                 310                 315                 320 
Pro Thr Thr Ala Asp Phe Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                325                 330                 335     
Leu Asp Ser Thr His His His His His His
            340                 345     


<210> 40
<211> 575
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      N-terminal 6xHis  affinity tag

<400> 40
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Arg Thr Arg Leu Glu Lys Ala Pro Thr
            20                  25                  30          
Leu Gln Thr Gly Gly Ser Cys Pro Ser Cys Ser Leu Ser Leu Ala Ser
        35                  40                  45              
Leu Arg Leu Lys Trp Gln Gly Glu Asn Gly Met Glu Asp Cys Val Met
    50                  55                  60                  
Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu Met
65                  70                  75                  80  
Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys
                85                  90                  95      
Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser Ile
            100                 105                 110         
His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys Lys
        115                 120                 125             
Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg
    130                 135                 140                 
Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu
145                 150                 155                 160 
Ile Val Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser
                165                 170                 175     
Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu
            180                 185                 190         
Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp
        195                 200                 205             
His Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met
    210                 215                 220                 
Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys
225                 230                 235                 240 
Thr Gly Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp Ile
                245                 250                 255     
Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe
            260                 265                 270         
Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro
        275                 280                 285             
Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg
    290                 295                 300                 
Ile Gln Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile
305                 310                 315                 320 
Thr Val Tyr Tyr Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val
                325                 330                 335     
Ile Glu Ser His Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu
            340                 345                 350         
Lys Pro Tyr Pro Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys
        355                 360                 365             
Thr Gln Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser
    370                 375                 380                 
Ser Leu Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala
385                 390                 395                 400 
Asn Gly Ser Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly
                405                 410                 415     
Asp Asn Arg Leu Asp Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile
            420                 425                 430         
Phe Gly Val Lys Asn Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu
        435                 440                 445             
Ile Gln Asn Gln Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys
    450                 455                 460                 
Val Thr Ala Gly Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu
465                 470                 475                 480 
Leu Cys Gln Tyr Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu
                485                 490                 495     
Cys Leu Met Gly Thr Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly
            500                 505                 510         
Gln Asn Gly Leu Thr His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val
        515                 520                 525             
Phe Gly Leu Arg Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln
    530                 535                 540                 
Thr Gln Glu Ile Thr Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys
545                 550                 555                 560 
Thr Val Tyr Val Ser Val Leu Pro Thr Thr Ala Asp Phe Leu Glu
                565                 570                 575 


<210> 41
<211> 575
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      C-terminal 6xHis  affinity tag

<400> 41
Met Gly Ser Arg Thr Arg Leu Glu Lys Ala Pro Thr Leu Gln Thr Gly
 1               5                  10                  15      
Gly Ser Cys Pro Ser Cys Ser Leu Ser Leu Ala Ser Leu Arg Leu Lys
            20                  25                  30          
Trp Gln Gly Glu Asn Gly Met Glu Asp Cys Val Met Ala Leu Glu Thr
        35                  40                  45              
Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu Met Ala Pro Tyr Thr
    50                  55                  60                  
Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys Val Leu Ile Asp
65                  70                  75                  80  
Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser Ile His Tyr Leu Met
                85                  90                  95      
Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala
            100                 105                 110         
Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp
        115                 120                 125             
Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile
    130                 135                 140                 
His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr
145                 150                 155                 160 
Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys
                165                 170                 175     
Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu
            180                 185                 190         
Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys
        195                 200                 205             
Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile
    210                 215                 220                 
Val Val Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr
225                 230                 235                 240 
Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser
                245                 250                 255     
Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met
            260                 265                 270         
Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu
        275                 280                 285             
Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr
    290                 295                 300                 
Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His
305                 310                 315                 320 
Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro
                325                 330                 335     
Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys
            340                 345                 350         
Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly
        355                 360                 365             
Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu
    370                 375                 380                 
Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu
385                 390                 395                 400 
Asp Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys
                405                 410                 415     
Asn Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln
            420                 425                 430         
Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly
        435                 440                 445             
Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr
    450                 455                 460                 
Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly
465                 470                 475                 480 
Thr Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu
                485                 490                 495     
Thr His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg
            500                 505                 510         
Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile
        515                 520                 525             
Thr Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val
    530                 535                 540                 
Ser Val Leu Pro Thr Thr Ala Asp Phe Leu Glu Gly Lys Pro Ile Pro
545                 550                 555                 560 
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                565                 570                 575 


<210> 42
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      n-terminal 6xHis (Genewiz)  affinity tag

<400> 42
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Glu Glu Leu Ile Asp Lys Lys Thr Glu
            20                  25                  30          
Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile
        35                  40                  45              
Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val
    50                  55                  60                  
Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu
65                  70                  75                  80  
Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr
                85                  90                  95      
Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met
            100                 105                 110         
Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser
        115                 120                 125             
Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly
    130                 135                 140                 
Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu
145                 150                 155                 160 
Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala
                165                 170                 175     
His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln
            180                 185                 190         
Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln
        195                 200                 205             
Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val
    210                 215                 220                 
Tyr Tyr Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu
225                 230                 235                 240 
Ser His Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro
                245                 250                 255     
Tyr Pro Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln
            260                 265                 270         
Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu
        275                 280                 285             
Pro Gly Pro Ala Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly
    290                 295                 300                 
Ser Glu Gln Gly Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn
305                 310                 315                 320 
Arg Leu Asp Leu Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly
                325                 330                 335     
Val Lys Asn Thr Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln
            340                 345                 350         
Asn Gln Thr Asp Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr
        355                 360                 365             
Ala Gly Ser Ala Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys
    370                 375                 380                 
Gln Tyr Ile Asn Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu
385                 390                 395                 400 
Met Gly Thr Val Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn
                405                 410                 415     
Gly Leu Thr His Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly
            420                 425                 430         
Leu Arg Ser Arg Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln
        435                 440                 445             
Glu Ile Thr Glu Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val
    450                 455                 460                 
Tyr Val Ser Val Leu Pro Thr Thr Ala Asp Phe Leu Glu
465                 470                 475         


<210> 43
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> Isoleucyl tRNA Synthetase polypeptide with
      C-terminal 6xHis (Genewiz)  affinity tag

<400> 43
Met Gly Ser Glu Glu Leu Ile Asp Lys Lys Thr Glu Ser Ala Val Ser
 1               5                  10                  15      
Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile Arg Asp Arg Lys
            20                  25                  30          
Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val Val Ile His Gln
        35                  40                  45              
Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu Lys Tyr Ile Ile
    50                  55                  60                  
Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr Asp Lys Asn Lys
65                  70                  75                  80  
Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met Val Leu Gly Lys
                85                  90                  95      
Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser Ile Lys Gln Leu
            100                 105                 110         
Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly Thr Ile Val Val
        115                 120                 125             
Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe
    130                 135                 140                 
Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala
145                 150                 155                 160 
Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp
                165                 170                 175     
Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys
            180                 185                 190         
Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala
        195                 200                 205             
Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu
    210                 215                 220                 
Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser
225                 230                 235                 240 
Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser
                245                 250                 255     
Glu Leu Glu Ile Thr Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala
            260                 265                 270         
Cys Ala Tyr Val Asn Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly
        275                 280                 285             
Gly Val Leu Leu Leu Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu
    290                 295                 300                 
Leu Lys Leu Lys Ser Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr
305                 310                 315                 320 
Glu Leu Ala Val Phe His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp
                325                 330                 335     
Leu Leu Ser Leu Ser Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala
            340                 345                 350         
Pro Ser Leu Ile Asn Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn
        355                 360                 365             
Leu Gln Leu Leu Asn Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val
    370                 375                 380                 
Gly Thr Leu Leu Leu Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His
385                 390                 395                 400 
Gln Gly Leu Leu Tyr Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg
                405                 410                 415     
Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu
            420                 425                 430         
Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val
        435                 440                 445             
Leu Pro Thr Thr Ala Asp Phe Leu Glu Gly Lys Pro Ile Pro Asn Pro
    450                 455                 460                 
Leu Leu Gly Leu Asp Ser Thr His His His His His His
465                 470                 475         


<210> 44
<211> 1368
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized (DNA2.0) Isoleucyl tRNA Synthetase
      polynucleotide

<400> 44
gaggagctga tcgacaagaa aaccgaaagc gcagtgagcc agatgcaaag cgttattgag 60
ctgggtcgtg tcatccgtga tcgtaagacc attccaatca aatacccgct gaaagagatc 120
gtggttattc accaagaccc tgaggcactg aaggacatca aaagcctgga gaaatacatt 180
attgaagagc tgaacgttcg taaagttacg ttgagcaccg acaagaataa gtatggcatt 240
cgcctgcgcg cagaaccgga tcacatggtg ctgggcaaac gcctgaaggg tgctttcaag 300
gcagtcatga cgagcattaa gcagctgagc tccgaagagc tggaacaatt ccagaaaacc 360
ggcaccatcg ttgtggaggg tcatgagctg cacgacgaag atattcgtct gatgtacacc 420
ttcgatcaag cgacgggcgg tacggcgcaa tttgaggccc atagcgacgc gcaggcgctg 480
gtgctgctgg atgtgacccc ggatcagtcg atggtggatg agggcatggc gcgtgaggtc 540
atcaaccgca ttcagaagtt gcgtaagaaa tgcaatctgg tccctacgga cgaaatcacg 600
gtttactata aagctaaaag cgagggcacg tatttgaact ctgtgattga aagccacacc 660
gagtttatct ttacgaccat caaagcaccg ctgaagccgt acccggtttc cccgtccgac 720
aaggtcctga tccaagagaa aacccagctg aagggtagcg agctggaaat caccttgact 780
cgcggtagca gcctgccggg tccggcgtgt gcgtacgtca atctgaacat ctgcgccaac 840
ggtagcgaac agggtggcgt tctgttgctg gagaatccga agggtgacaa tcgtctggac 900
ctgctgaaac tgaaaagcgt cgtgaccagc atttttggtg tgaagaacac cgagctggcg 960
gttttccatg acgaaactga aattcagaac cagaccgatc tgctgtcttt gagcggcaaa 1020
acgctgtgcg ttactgctgg ttcggcaccg agcctgatta acagctctag cacgctgctg 1080
tgtcagtaca tcaatctgca gctgctgaat gcgaagccgc aagagtgttt gatgggtacg 1140
gttggcaccc tgctgctgga gaacccactg ggccaaaacg gtttgaccca ccaaggtctg 1200
ctgtatgaag ccgcgaaggt gttcggtttg cgttcccgta aactgaagtt gtttctgaat 1260
gaaacccaaa cccaggaaat taccgaagat atcccggtca aaacgttgaa tatgaaaacc 1320
gtgtatgtca gcgtactgcc gaccactgcc gatttctaat gactcgag              1368

<210> 45
<211> 1572
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Isoleucyl tRNA Synthetase
      polynucleotide

<400> 45
ggatccaaag gcgagaacgg tatggaggat tgtgtgatgg cactggaaac cctgtttagc 60
gtactgctgt ctctgtgtcg tctgatggct ccgtatacac catttctgac cgagctgatg 120
tatcaaaacc tgaaagtgct gatcgatccg gttagtgtcc aggataaaga caccctgagc 180
atccattatc tgatgctgcc tcgtgttcgt gaagaactga ttgataaaaa aaccgagagc 240
gccgtttctc aaatgcagtc cgtcattgaa ctgggtcgtg tcatccgtga tcgtaaaacc 300
attccgatca aatatccgct gaaagagatc gttgtcattc accaagaccc ggaagctctg 360
aaagacatca aaagcctgga gaaatatatc atcgaggagc tgaacgttcg taaagtgacc 420
ctgagtaccg acaaaaacaa atatggcatc cgtctgcgtg cagaaccaga tcacatggtg 480
ctgggtaaac gtctgaaagg agcattcaaa gccgttatga cctctattaa acaactgtcg 540
agcgaagagc tggaacagtt tcaaaaaacg ggcacgattg tggttgaagg ccatgaactg 600
cacgatgagg atattcgcct gatgtatacc tttgatcagg caaccggtgg tacagctcaa 660
ttcgaagccc attcagatgc ccaagcactg gtcctgctgg atgttacacc agaccagagt 720
atggttgatg aaggcatggc acgtgaagtg attaaccgta ttcaaaaact gcgtaaaaaa 780
tgtaacctgg tgccgaccga tgaaatcacc gtgtattata aagccaaatc cgaggggaca 840
tatctgaaca gcgttatcga atcccacacc gaattcattt tcaccaccat taaagcacct 900
ctgaaaccgt atccggttag tccgagcgat aaagtgctga tccaggagaa aacacagctg 960
aaaggctctg aactggaaat cacgctgact cgtggttcat ctctgccagg tccggcatgt 1020
gcttatgtta acctgaacat ctgtgccaat ggtagcgaac aaggtggagt gctgctgctg 1080
gaaaatccga aaggcgataa tcgtctggac ctgctgaaac tgaaaagcgt ggttaccagc 1140
atttttggcg tgaaaaacac ggaactggcg gttttccatg atgagactga gatccagaac 1200
caaaccgatc tgctgagtct gagtggtaaa acactgtgtg tgaccgccgg tagtgctcca 1260
tctctgatta acagctcatc caccctgctg tgccagtata ttaacctgca gctgctgaat 1320
gccaaacctc aggaatgtct gatgggtaca gtgggtacac tgctgctgga gaaccctctg 1380
ggacaaaatg gactgaccca ccaaggtctg ctgtatgaag cagccaaagt gttcggtctg 1440
cgcagtcgta aactgaaact gtttctgaac gaaacccaga cccaagaaat caccgaggat 1500
atcccggtaa aaaccctgaa tatgaaaacg gtctatgtga gcgttctgcc gacaacagcc 1560
gattttctcg ag                                                     1572

<210> 46
<211> 987
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Isoleucyl tRNA Synthetase
      polynucleotide

<400> 46
cacgagctgc acgacgaaga catccgcctg atgtacacgt tcgatcaagc gaccggtggt 60
acggcacagt ttgaggcgca ctctgatgcg caagcactgg ttctgctgga tgttacgccg 120
gaccagagca tggttgatga gggtatggca cgtgaggtga ttaaccgcat tcagaagctg 180
cgtaagaaat gtaacttggt tccgactgac gaaatcacgg tctattacaa agcgaagagc 240
gagggcacct atttgaatag cgtgattgag agccacaccg aattcatctt cactaccatt 300
aaagccccgt tgaagccgta cccggttagc ccgagcgaca aggtgctgat ccaggaaaag 360
acgcaactga aaggcagcga actggagatt acgctgaccc gtggcagcag cctgccgggt 420
ccggcctgcg cgtatgttaa cctgaatatc tgcgcgaacg gttccgagca gggtggtgtt 480
ctgctgctgg agaatccaaa aggtgataac cgtctggatc tgttgaagct gaagagcgtc 540
gtcacctcta tcttcggtgt gaagaatacc gagttggctg tctttcatga cgaaacggag 600
attcaaaacc agactgacct gctgagcttg tctggcaaga ccctgtgcgt gaccgcgggt 660
agcgctccat cgctgattaa ctccagctcc acgctgctgt gtcagtatat caatctgcaa 720
ctgctgaatg cgaaaccgca agagtgtctg atgggtacgg tgggcaccct gctgttggag 780
aaccctctgg gtcaaaatgg cctgacccat caaggcttgc tgtacgaagc cgcaaaagtg 840
tttggcctgc gtagccgcaa actgaaactg tttctgaacg aaacgcagac ccaggaaatt 900
accgaagata tcccggtcaa aaccctgaat atgaaaaccg tgtacgtcag cgttctgccg 960
accaccgcag acttctaatg actcgag                                     987

<210> 47
<211> 1662
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Isoleucyl tRNA Synthetase
      polynucleotide

<400> 47
ggatcccgta ctcgtctgga aaaagctcct accctgcaaa ctggtggttc ttgtccgtca 60
tgttcactgt ctctggcctc actgcgtctg aaatggcaag gcgaaaacgg tatggaagat 120
tgtgttatgg ccctggaaac cctgtttagc gttctgctgt ctctgtgtcg tctgatggct 180
ccgtatacac cttttctgac cgagctgatg tatcaaaacc tgaaagtgct gatcgatccg 240
gttagtgtac aggataaaga caccctgagc atccattatc tgatgctgcc tcgtgttcgt 300
gaagagctga ttgataaaaa aaccgagagc gccgttagtc aaatgcagag cgtcatcgaa 360
ctgggtcgtg taatccgtga tcgtaaaacc attccgatca aatatccgct gaaagaaatc 420
gtggtgattc accaggaccc tgaagcactg aaagacatca aaagcctgga gaaatatatc 480
attgaggaac tgaacgtccg taaagtgact ctgtccaccg ataaaaacaa atatggcatc 540
cgtctgcgtg ctgaacctga tcacatggtt ctgggtaaac gcctgaaagg ggcctttaaa 600
gccgtaatga cctccatcaa acaactgagc agcgaagagc tggaacaatt ccaaaaaacg 660
ggcaccattg tggttgaagg gcatgaactg cacgatgagg atatccgcct gatgtatacc 720
tttgaccagg caacaggtgg aacagcacaa tttgaagccc atagcgacgc ccaagcgctg 780
gtactgctgg atgttactcc ggaccagtct atggtggatg aggggatggc acgtgaagtg 840
attaatcgta tccaaaaact gcgtaaaaaa tgtaatctgg tgccgaccga tgaaatcacc 900
gtgtattata aagccaaaag cgagggcacg tatctgaata gcgttattga aagccacacc 960
gaattcatct ttacaacaat caaagcccct ctgaaaccgt atccggtaag ccctagtgat 1020
aaagtgctga ttcaggagaa aacccagctg aaaggctctg aactggaaat cacgctgaca 1080
cgtggtagta gtctgccagg acctgcttgt gcctatgtta atctgaacat ctgtgccaat 1140
ggtagcgaac aaggtggtgt cctgctgctg gaaaatccga aaggcgataa ccgtctggat 1200
ctgctgaaac tgaaaagcgt tgtgacctcg atcttcggcg tgaaaaacac tgagctggcc 1260
gtgtttcatg atgagactga gattcaaaat caaaccgacc tgctgagtct gtctggtaaa 1320
acgctgtgtg ttaccgctgg ttccgctcct agtctgatca atagcagctc tacactgctg 1380
tgtcagtata tcaacctgca gctgctgaat gccaaacctc aggaatgtct gatgggcact 1440
gttggtactc tgctgctgga gaacccactg ggacaaaatg gtctgaccca ccaaggtctg 1500
ctgtatgaag cagccaaagt gttcggactg cgtagtcgta aactgaaact gtttctgaac 1560
gaaacccaaa ctcaagagat caccgaggac atcccggtta aaacgctgaa tatgaaaacc 1620
gtgtatgtga gcgtactgcc gacaacagcc gattttctcg ag                    1662

<210> 48
<211> 1368
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Isoleucyl tRNA Synthetase
      polynucleotide

<400> 48
ggatccgaag agctgatcga caaaaaaacg gagagcgctg ttagccaaat gcagtctgtg 60
atcgaactgg gtcgtgttat tcgtgaccgt aaaaccatcc cgatcaaata tccgctgaaa 120
gaaatcgtcg tcatccacca ggaccctgaa gcactgaaag acatcaaatc gctggagaaa 180
tatatcattg aggaactgaa cgtccgtaaa gtgaccctgt ctaccgataa aaacaaatat 240
ggcatccgcc tgcgtgcaga acctgaccac atggtgctgg gaaaacgtct gaaaggtgcc 300
tttaaagccg ttatgaccag tatcaaacaa ctgtcctccg aagaactgga gcagtttcaa 360
aaaaccggca cgatcgtcgt tgaaggccat gaactgcacg atgaggatat tcgtctgatg 420
tataccttcg accaggcaac aggtggcaca gcccaatttg aagctcattc cgatgctcaa 480
gcgctggtac tgctggacgt gacaccggat caatcaatgg tggacgaagg catggcacgt 540
gaagtgatta accgtatcca aaaactgcgt aaaaaatgta acctggttcc gaccgacgaa 600
atcaccgtgt attataaagc caaaagcgag ggcacatatc tgaatagcgt tattgagagc 660
cacaccgaat tcatctttac cacgattaaa gcccctctga aaccatatcc agtgagcccg 720
agcgataaag ttctgatcca ggagaaaacc cagctgaaag gctctgaact ggaaatcacg 780
ctgacacgtg gttctagtct gccaggtccg gcatgtgctt atgtgaatct gaacatctgt 840
gctaatggca gcgaacaagg tggtgtgctg ctgctggaaa atccgaaagg tgacaatcgt 900
ctggatctgc tgaaactgaa aagcgtggtt accagcattt ttggcgtgaa aaacaccgag 960
ctggccgtgt ttcatgatga gacagaaatt caaaaccaga ccgacctgct gtcactgtca 1020
ggcaaaaccc tgtgtgttac cgctggaagc gccccttctc tgattaatag cagctcaacc 1080
ctgctgtgtc agtatatcaa cctgcaactg ctgaatgcta aacctcagga atgtctgatg 1140
ggcactgttg gtacactgct gctggagaac ccactgggtc aaaatggtct gacccatcaa 1200
ggtctgctgt atgaagcagc caaagtgttt ggtctgcgta gccgtaaact gaaactgttt 1260
ctgaacgaaa cccaaactca agagatcacc gaggatatcc cggtaaaaac tctgaatatg 1320
aaaaccgtct atgtgagcgt actgccgaca acagccgact tcctcgag              1368

<210> 49
<211> 875
<212> PRT
<213> Homo sapiens

<400> 49
Gln Asn Tyr Lys Asp Val Gln Asp Pro Ser Val Phe Val Thr Phe Pro
 1               5                  10                  15      
Leu Glu Glu Asp Glu Thr Val Ser Leu Val Ala Trp Thr Thr Thr Pro
            20                  25                  30          
Trp Thr Leu Pro Ser Asn Leu Ala Val Cys Val Asn Pro Glu Met Gln
        35                  40                  45              
Tyr Val Lys Ile Lys Asp Val Ala Arg Gly Arg Leu Leu Ile Leu Met
    50                  55                  60                  
Glu Ala Arg Leu Ser Ala Leu Tyr Lys Leu Glu Ser Asp Tyr Glu Ile
65                  70                  75                  80  
Leu Glu Arg Phe Pro Gly Ala Tyr Leu Lys Gly Lys Lys Tyr Arg Pro
                85                  90                  95      
Leu Phe Asp Tyr Phe Leu Lys Cys Lys Glu Asn Gly Ala Phe Thr Val
            100                 105                 110         
Leu Val Asp Asn Tyr Val Lys Glu Glu Glu Gly Thr Gly Val Val His
        115                 120                 125             
Gln Ala Pro Tyr Phe Gly Ala Glu Asp Tyr Arg Val Cys Met Asp Phe
    130                 135                 140                 
Asn Ile Ile Arg Lys Asp Ser Leu Pro Val Cys Pro Val Asp Ala Ser
145                 150                 155                 160 
Gly Cys Phe Thr Thr Glu Val Thr Asp Phe Ala Gly Gln Tyr Val Lys
                165                 170                 175     
Asp Ala Asp Lys Ser Ile Ile Arg Thr Leu Lys Glu Gln Gly Arg Leu
            180                 185                 190         
Leu Val Ala Thr Thr Phe Thr His Ser Tyr Pro Phe Cys Trp Arg Ser
        195                 200                 205             
Asp Thr Pro Leu Ile Tyr Lys Ala Val Pro Ser Trp Phe Val Arg Val
    210                 215                 220                 
Glu Asn Met Val Asp Gln Leu Leu Arg Asn Asn Asp Leu Cys Tyr Trp
225                 230                 235                 240 
Val Pro Glu Leu Val Arg Glu Lys Arg Phe Gly Asn Trp Leu Lys Asp
                245                 250                 255     
Ala Arg Asp Trp Thr Ile Ser Arg Asn Arg Tyr Trp Gly Thr Pro Ile
            260                 265                 270         
Pro Leu Trp Val Ser Asp Asp Phe Glu Glu Val Val Cys Ile Gly Ser
        275                 280                 285             
Val Ala Glu Leu Glu Glu Leu Ser Gly Ala Lys Ile Ser Asp Leu His
    290                 295                 300                 
Arg Glu Ser Val Asp His Leu Thr Ile Pro Ser Arg Cys Gly Lys Gly
305                 310                 315                 320 
Ser Leu His Arg Ile Ser Glu Val Phe Asp Cys Trp Phe Glu Ser Gly
                325                 330                 335     
Ser Met Pro Tyr Ala Gln Val His Tyr Pro Phe Glu Asn Lys Arg Glu
            340                 345                 350         
Phe Glu Asp Ala Phe Pro Ala Asp Phe Ile Ala Glu Gly Ile Asp Gln
        355                 360                 365             
Thr Arg Gly Trp Phe Tyr Thr Leu Leu Val Leu Ala Thr Ala Leu Phe
    370                 375                 380                 
Gly Gln Pro Pro Phe Lys Asn Val Ile Val Asn Gly Leu Val Leu Ala
385                 390                 395                 400 
Ser Asp Gly Gln Lys Met Ser Lys Arg Lys Lys Asn Tyr Pro Asp Pro
                405                 410                 415     
Val Ser Ile Ile Gln Lys Tyr Gly Ala Asp Ala Leu Arg Leu Tyr Leu
            420                 425                 430         
Ile Asn Ser Pro Val Val Arg Ala Glu Asn Leu Arg Phe Lys Glu Glu
        435                 440                 445             
Gly Val Arg Asp Val Leu Lys Asp Val Leu Leu Pro Trp Tyr Asn Ala
    450                 455                 460                 
Tyr Arg Phe Leu Ile Gln Asn Val Leu Arg Leu Gln Lys Glu Glu Glu
465                 470                 475                 480 
Ile Glu Phe Leu Tyr Asn Glu Asn Thr Val Arg Glu Ser Pro Asn Ile
                485                 490                 495     
Thr Asp Arg Trp Ile Leu Ser Phe Met Gln Ser Leu Ile Gly Phe Phe
            500                 505                 510         
Glu Thr Glu Met Ala Ala Tyr Arg Leu Tyr Thr Val Val Pro Arg Leu
        515                 520                 525             
Val Lys Phe Val Asp Ile Leu Thr Asn Trp Tyr Val Arg Met Asn Arg
    530                 535                 540                 
Arg Arg Leu Lys Gly Glu Asn Gly Met Glu Asp Cys Val Met Ala Leu
545                 550                 555                 560 
Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu Met Ala Pro
                565                 570                 575     
Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu Lys Val Leu
            580                 585                 590         
Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser Ile His Tyr
        595                 600                 605             
Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys Lys Thr Glu
    610                 615                 620                 
Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly Arg Val Ile
625                 630                 635                 640 
Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys Glu Ile Val
                645                 650                 655     
Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys Ser Leu Glu
            660                 665                 670         
Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr Leu Ser Thr
        675                 680                 685             
Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro Asp His Met
    690                 695                 700                 
Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val Met Thr Ser
705                 710                 715                 720 
Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln Lys Thr Gly
                725                 730                 735     
Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp Ile Arg Leu
            740                 745                 750         
Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln Phe Glu Ala
        755                 760                 765             
His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr Pro Asp Gln
    770                 775                 780                 
Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn Arg Ile Gln
785                 790                 795                 800 
Lys Leu Arg Lys Lys Cys Asn Leu Val Pro Thr Asp Glu Ile Thr Val
                805                 810                 815     
Tyr Tyr Lys Ala Lys Ser Glu Gly Thr Tyr Leu Asn Ser Val Ile Glu
            820                 825                 830         
Ser His Thr Glu Phe Ile Phe Thr Thr Ile Lys Ala Pro Leu Lys Pro
        835                 840                 845             
Tyr Pro Val Ser Pro Ser Asp Lys Val Leu Ile Gln Glu Lys Thr Gln
    850                 855                 860                 
Leu Lys Gly Ser Glu Leu Glu Ile Thr Leu Thr
865                 870                 875 


<210> 50
<211> 2625
<212> DNA
<213> Homo sapiens

<400> 50
cagaattata aggatgttca agatccttca gtatttgtaa ctttcccttt ggaagaagat 60
gaaactgtat ctttagttgc ttggacaacc actccctgga ctctacctag taaccttgct 120
gtgtgtgtta atccagaaat gcaatatgtg aaaattaaag atgttgccag aggacgatta 180
ctcattttaa tggaagccag attgtcagcc ctctataaat tggagagtga ctatgagatc 240
cttgaaagat ttcctggtgc ctatcttaaa ggcaagaagt acaggcccct gtttgactat 300
ttcctgaagt gtaaagagaa tggcgctttc actgtgcttg ttgacaacta tgtgaaggaa 360
gaagaaggca caggggttgt ccaccaagct ccttacttcg gtgctgagga ctatcgggtc 420
tgtatggact ttaacattat tcggaaagac tcactccctg tttgccctgt ggatgcttca 480
ggctgcttca caacggaggt gacagatttc gcaggacagt atgtgaagga tgctgacaaa 540
agtatcatca ggactttgaa ggaacaaggc cgacttctgg ttgccaccac cttcactcac 600
agctaccctt tttgctggag atcagacact cctctaattt acaaagcagt gcccagctgg 660
tttgtgcgag tggagaacat ggtggaccag ctcctaagga acaatgacct gtgctactgg 720
gtcccagagt tggtacgaga aaaacgattt ggaaattggc tgaaagatgc acgtgactgg 780
acaatttcca gaaacagata ctggggcacc cccatcccac tgtgggtcag cgatgacttt 840
gaggaggtgg tatgcattgg gtcagtggcg gaacttgaag aactgtcagg agcaaagatc 900
tcagatctcc acagagagag tgttgaccac ctgaccattc cttcacgctg tgggaaggga 960
tccttgcacc gcatctctga agtgtttgac tgttggtttg agagtggcag catgccctat 1020
gctcaggttc attacccgtt tgaaaacaag agggagtttg aggatgcttt tcctgcagat 1080
ttcattgccg agggcatcga ccaaaccaga ggatggtttt ataccctgct ggtgctggcc 1140
acggccctct ttggacaacc gcctttcaag aacgtaattg tgaatgggct tgtcctggca 1200
agtgatggcc aaaaaatgag caaacggaaa aagaattatc cagatccagt ttccatcatc 1260
cagaagtatg gtgctgatgc cctcagatta tatctgatta actcccctgt ggtgagagca 1320
gaaaacctcc gctttaaaga agagggtgtg cgggacgtcc ttaaggatgt actgctccca 1380
tggtacaatg cctatcgctt cttaatccag aacgttctga ggctccagaa ggaggaagaa 1440
atagaatttc tctacaatga gaacacggtt agagaaagcc ccaacattac agaccggtgg 1500
atcctgtcct tcatgcagtc tctcattggc ttctttgaga ctgaaatggc agcttatagg 1560
ctttatactg tggtgcctcg cctggtcaag tttgtagata ttctgaccaa ttggtatgtt 1620
agaatgaacc gcagaagatt aaagggtgaa aatgggatgg aggattgtgt catggcccta 1680
gaaaccttgt ttagtgttct gctttctctt tgcagactta tggctcccta cacacctttt 1740
ctcactgaat tgatgtacca gaatctaaag gtgctgattg accctgtttc tgttcaggac 1800
aaggacacac tcagcattca ctacctcatg ctgccccgtg ttcgagaaga attgattgac 1860
aagaaaacag agagtgcagt atctcagatg cagtctgtga ttgaacttgg aagagtgatc 1920
agagaccgaa aaactattcc cataaagtat cctttgaaag aaattgtggt tatccatcaa 1980
gatccagaag ctcttaaaga tatcaagtct ttggagaagt atatcattga ggaactcaat 2040
gttcgaaaag ttacactgtc tacagataaa aacaagtatg gcattcggct aagggcagaa 2100
ccagatcaca tggtcctggg gaagcgtctg aagggagcct ttaaggcagt gatgacgtcc 2160
atcaagcagt tgagcagtga ggagctggag cagttccaga agactgggac cattgttgtg 2220
gaaggccatg aattgcacga tgaagacatc cgcctcatgt acacctttga tcaggccaca 2280
ggtgggactg cgcaatttga agcacactca gatgctcagg ctttggtcct cttagatgtc 2340
actcctgacc agtcaatggt agatgaagga atggctcggg aagtcatcaa tcgcatacag 2400
aaacttcgca aaaagtgcaa tctggttcca actgatgaaa tcacagtgta ctataaagca 2460
aagtctgaag gaacatatct gaatagtgtt attgaaagcc acacagagtt catatttacc 2520
accataaagg ctcccttgaa accatatcca gtttctccat cggataaagt ccttattcaa 2580
gaaaaaacac agttgaaggg atctgaactg gaaattacac tcacc                 2625
