
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited		
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF CYSTEINYL-tRNA SYNTHETASE
  

<130> 120161.438PC

<140> PCT                 
<141> 2011-04-26  

<150> US 61/328,079       
<151> 2010-04-26  

<150> US 61/328,081       
<151> 2010-04-26  

<150> US 61/328,087       
<151> 2010-04-26  

<160> 114

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 99
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Pro Thr Ser Leu
                85                  90                  95      
Leu Ile Ser
            


<210> 13
<211> 300
<212> DNA
<213> Homo sapiens

<400> 13
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagtccta catctctttt gatatcttga 300


<210> 14
<211> 387
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Leu Leu
385         


<210> 15
<211> 1164
<212> DNA
<213> Homo sapiens

<400> 15
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggaag tgttcatacc tcaagatggg aaaaaggtga cgtggtattg ctgtgggcca 420
accgtctatg acgcatctca catggggcac gccaggtcct acatctcttt tgatatcttg 480
agaagagtgt tgaaggatta cttcaaattt gatgtctttt attgcatgaa cattacggat 540
attgatgaca agatcatcaa gagggcccgg cagaaccacc tgttcgagca gtatcgggag 600
aagaggcctg aagcggcaca gctcttggag gatgttcagg ccgccctgaa gccattttca 660
gtaaaattaa atgagaccac ggatcccgat aaaaagcaga tgctcgaacg gattcagcac 720
gcagtgcagc ttgccacaga gccacttgag aaagctgtgc agtccagact cacgggagag 780
gaagtcaaca gctgtgtgga ggtgttgctg gaagaagcca aggatttgct ctctgactgg 840
ctggattcta cacttggctg tgatgtcact gacaattcca tcttctccaa gctgcccaag 900
ttctgggagg gggacttcca cagagacatg gaagctctga atgttctccc tccagatgtc 960
ttaacccggg ttagtgagta tgtgccagaa attgtgaact ttgtccagaa gattgtggac 1020
aacggttacg gctatgtctc caatgggtct gtctactttg atacagcgaa gtttgcttct 1080
agcgagaagc actcctatgg gaagctggtg cctgaggccg ttggagatca gaaagccctt 1140
caagaagggg aaggcctact ttga                                        1164

<210> 16
<211> 545
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro
385                 390                 395                 400 
Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp
                405                 410                 415     
Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser
            420                 425                 430         
Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly
        435                 440                 445             
Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser
    450                 455                 460                 
Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr
465                 470                 475                 480 
Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn
                485                 490                 495     
Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu
            500                 505                 510         
Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser
        515                 520                 525             
Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Leu
    530                 535                 540                 
Leu
545 


<210> 17
<211> 1638
<212> DNA
<213> Homo sapiens

<400> 17
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggaag tgttcatacc tcaagatggg aaaaaggtga cgtggtattg ctgtgggcca 420
accgtctatg acgcatctca catggggcac gccaggtcct acatctcttt tgatatcttg 480
agaagagtgt tgaaggatta cttcaaattt gatgtctttt attgcatgaa cattacggat 540
attgatgaca agatcatcaa gagggcccgg cagaaccacc tgttcgagca gtatcgggag 600
aagaggcctg aagcggcaca gctcttggag gatgttcagg ccgccctgaa gccattttca 660
gtaaaattaa atgagaccac ggatcccgat aaaaagcaga tgctcgaacg gattcagcac 720
gcagtgcagc ttgccacaga gccacttgag aaagctgtgc agtccagact cacgggagag 780
gaagtcaaca gctgtgtgga ggtgttgctg gaagaagcca aggatttgct ctctgactgg 840
ctggattcta cacttggctg tgatgtcact gacaattcca tcttctccaa gctgcccaag 900
ttctgggagg gggacttcca cagagacatg gaagctctga atgttctccc tccagatgtc 960
ttaacccggg ttagtgagta tgtgccagaa attgtgaact ttgtccagaa gattgtggac 1020
aacggttacg gctatgtctc caatgggtct gtctactttg atacagcgaa gtttgcttct 1080
agcgagaagc actcctatgg gaagctggtg cctgaggccg ttggagatca gaaagccctt 1140
caagaagggg aaggtgacct gagcatctct gcagaccgcc tgagtgagaa gcgctctccc 1200
aacgactttg ccttatggaa ggcctctaag cccggagaac cgtcctggcc gtgcccttgg 1260
ggaaagggtc gtccgggctg gcatatcgag tgctcggcca tggcaggcac cctcctaggg 1320
gcttcgatgg acattcacgg aggtgggttc gacctccggt tcccccacca tgacaatgag 1380
ctggcacagt cggaggccta ctttgaaaac gactgctggg tcaggtactt cctgcacaca 1440
ggccacctga ccattgcagg ctgcaaaatg tcaaagtcac taaaaaactt catcaccatt 1500
aaagatgcct tgaaaaagca ctcagcacgg cagttgcggc tggccttcct catgcactcg 1560
tggaaggaca ccctggacta ctccagcaac accatggagt cagcgcttca atatgagaag 1620
ttcttgaatc ttttatga                                               1638

<210> 18
<211> 127
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Val Leu His Leu Phe
        115                 120                 125         


<210> 19
<211> 384
<212> DNA
<213> Homo sapiens

<400> 19
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggtcc tacatctctt ttga                                        384

<210> 20
<211> 788
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro
385                 390                 395                 400 
Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp
                405                 410                 415     
Pro Cys Pro Trp Gly Lys Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg
            420                 425                 430         
Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser
        435                 440                 445             
Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His
    450                 455                 460                 
Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp
465                 470                 475                 480 
Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu
                485                 490                 495     
Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala
            500                 505                 510         
Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala
        515                 520                 525             
Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala
    530                 535                 540                 
Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala
545                 550                 555                 560 
Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg
                565                 570                 575     
Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr
            580                 585                 590         
His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly
        595                 600                 605             
Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val
    610                 615                 620                 
Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys
625                 630                 635                 640 
Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala
                645                 650                 655     
Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His
            660                 665                 670         
Glu Gly Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu
        675                 680                 685             
Lys Glu Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys
    690                 695                 700                 
Lys Glu Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu
705                 710                 715                 720 
Ala Lys Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp
                725                 730                 735     
Lys Tyr Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu
            740                 745                 750         
Gly Lys Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe
        755                 760                 765             
Glu Ala Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn
    770                 775                 780                 
Gly Ser Phe Gln
785             


<210> 21
<211> 2367
<212> DNA
<213> Homo sapiens

<400> 21
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggaag tgttcatacc tcaagatggg aaaaaggtga cgtggtattg ctgtgggcca 420
accgtctatg acgcatctca catggggcac gccaggtcct acatctcttt tgatatcttg 480
agaagagtgt tgaaggatta cttcaaattt gatgtctttt attgcatgaa cattacggat 540
attgatgaca agatcatcaa gagggcccgg cagaaccacc tgttcgagca gtatcgggag 600
aagaggcctg aagcggcaca gctcttggag gatgttcagg ccgccctgaa gccattttca 660
gtaaaattaa atgagaccac ggatcccgat aaaaagcaga tgctcgaacg gattcagcac 720
gcagtgcagc ttgccacaga gccacttgag aaagctgtgc agtccagact cacgggagag 780
gaagtcaaca gctgtgtgga ggtgttgctg gaagaagcca aggatttgct ctctgactgg 840
ctggattcta cacttggctg tgatgtcact gacaattcca tcttctccaa gctgcccaag 900
ttctgggagg gggacttcca cagagacatg gaagctctga atgttctccc tccagatgtc 960
ttaacccggg ttagtgagta tgtgccagaa attgtgaact ttgtccagaa gattgtggac 1020
aacggttacg gctatgtctc caatgggtct gtctactttg atacagcgaa gtttgcttct 1080
agcgagaagc actcctatgg gaagctggtg cctgaggccg ttggagatca gaaagccctt 1140
caagaagggg aaggtgacct gagcatctct gcagaccgcc tgagtgagaa gcgctctccc 1200
aacgactttg ccttatggaa ggcctctaag cccggagaac cgtcctggcc gtgcccttgg 1260
ggaaaggcct actttgaaaa cgactgctgg gtcaggtact tcctgcacac aggccacctg 1320
accattgcag gctgcaaaat gtcaaagtca ctaaaaaact tcatcaccat taaagatgcc 1380
ttgaaaaagc actcagcacg gcagttgcgg ctggccttcc tcatgcactc gtggaaggac 1440
accctggact actccagcaa caccatggag tcagcgcttc aatatgagaa gttcttgaat 1500
gagtttttct taaatgtgaa agatatcctt cgcgctcctg ttgacatcac tggtcagttt 1560
gagaagtggg gagaagaaga agcagaactg aataagaact tttatgacaa gaagacagca 1620
attcacaaag ccctctgtga caatgttgac acccgcaccg tcatggaaga gatgcgggcc 1680
ttggtcagtc agtgcaacct ctatatggca gcccggaaag ccgtgaggaa gaggcccaac 1740
caggctctgc tggagaacat cgccctgtac ctcacccata tgctgaagat ctttggggcc 1800
gtagaagagg acagctccct gggattcccg gtcggagggc ctggaaccag cctcagtctc 1860
gaggccacag tcatgcccta ccttcaggtg ttatcagaat tccgagaagg agtgcggaag 1920
attgcccgag agcaaaaagt ccctgagatt ctgcagctca gcgatgccct gcgggacaac 1980
atcctgcccg agcttggggt gcggtttgaa gaccacgaag gactgcccac agtggtgaaa 2040
ctggtagaca gaaacacctt attaaaagag agagaagaaa agagacgggt tgaagaggag 2100
aagaggaaga agaaagagga ggcggcccgg aggaaacagg aacaagaagc agcaaagctg 2160
gccaagatga agattccccc cagtgagatg ttcttgtcag aaaccgacaa atactccaag 2220
tttgatgaaa atggtctgcc cacacatgac atggagggca aagagctcag caaagggcaa 2280
gccaagaagc tgaagaagct cttcgaggct caggagaagc tctacaagga atatctgcag 2340
atggcccaga atggaagctt ccagtga                                     2367

<210> 22
<211> 803
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro
385                 390                 395                 400 
Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp
                405                 410                 415     
Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser
            420                 425                 430         
Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly
        435                 440                 445             
Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser
    450                 455                 460                 
Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr
465                 470                 475                 480 
Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn
                485                 490                 495     
Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu
            500                 505                 510         
Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser
        515                 520                 525             
Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu
    530                 535                 540                 
Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr
545                 550                 555                 560 
Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn
                565                 570                 575     
Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val
            580                 585                 590         
Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys
        595                 600                 605             
Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln
    610                 615                 620                 
Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile
625                 630                 635                 640 
Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly
                645                 650                 655     
Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln
            660                 665                 670         
Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln
        675                 680                 685             
Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile
    690                 695                 700                 
Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr
705                 710                 715                 720 
Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu
                725                 730                 735     
Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala
            740                 745                 750         
Arg Arg Lys Gln Glu Gln Glu Gly Leu Pro Thr His Asp Met Glu Gly
        755                 760                 765             
Lys Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu
    770                 775                 780                 
Ala Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly
785                 790                 795                 800 
Ser Phe Gln
            


<210> 23
<211> 2412
<212> DNA
<213> Homo sapiens

<400> 23
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggaag tgttcatacc tcaagatggg aaaaaggtga cgtggtattg ctgtgggcca 420
accgtctatg acgcatctca catggggcac gccaggtcct acatctcttt tgatatcttg 480
agaagagtgt tgaaggatta cttcaaattt gatgtctttt attgcatgaa cattacggat 540
attgatgaca agatcatcaa gagggcccgg cagaaccacc tgttcgagca gtatcgggag 600
aagaggcctg aagcggcaca gctcttggag gatgttcagg ccgccctgaa gccattttca 660
gtaaaattaa atgagaccac ggatcccgat aaaaagcaga tgctcgaacg gattcagcac 720
gcagtgcagc ttgccacaga gccacttgag aaagctgtgc agtccagact cacgggagag 780
gaagtcaaca gctgtgtgga ggtgttgctg gaagaagcca aggatttgct ctctgactgg 840
ctggattcta cacttggctg tgatgtcact gacaattcca tcttctccaa gctgcccaag 900
ttctgggagg gggacttcca cagagacatg gaagctctga atgttctccc tccagatgtc 960
ttaacccggg ttagtgagta tgtgccagaa attgtgaact ttgtccagaa gattgtggac 1020
aacggttacg gctatgtctc caatgggtct gtctactttg atacagcgaa gtttgcttct 1080
agcgagaagc actcctatgg gaagctggtg cctgaggccg ttggagatca gaaagccctt 1140
caagaagggg aaggtgacct gagcatctct gcagaccgcc tgagtgagaa gcgctctccc 1200
aacgactttg ccttatggaa ggcctctaag cccggagaac cgtcctggcc gtgcccttgg 1260
ggaaagggtc gtccgggctg gcatatcgag tgctcggcca tggcaggcac cctcctaggg 1320
gcttcgatgg acattcacgg aggtgggttc gacctccggt tcccccacca tgacaatgag 1380
ctggcacagt cggaggccta ctttgaaaac gactgctggg tcaggtactt cctgcacaca 1440
ggccacctga ccattgcagg ctgcaaaatg tcaaagtcac taaaaaactt catcaccatt 1500
aaagatgcct tgaaaaagca ctcagcacgg cagttgcggc tggccttcct catgcactcg 1560
tggaaggaca ccctggacta ctccagcaac accatggagt cagcgcttca atatgagaag 1620
ttcttgaatg agtttttctt aaatgtgaaa gatatccttc gcgctcctgt tgacatcact 1680
ggtcagtttg agaagtgggg agaagaagaa gcagaactga ataagaactt ttatgacaag 1740
aagacagcaa ttcacaaagc cctctgtgac aatgttgaca cccgcaccgt catggaagag 1800
atgcgggcct tggtcagtca gtgcaacctc tatatggcag cccggaaagc cgtgaggaag 1860
aggcccaacc aggctctgct ggagaacatc gccctgtacc tcacccatat gctgaagatc 1920
tttggggccg tagaagagga cagctccctg ggattcccgg tcggagggcc tggaaccagc 1980
ctcagtctcg aggccacagt catgccctac cttcaggtgt tatcagaatt ccgagaagga 2040
gtgcggaaga ttgcccgaga gcaaaaagtc cctgagattc tgcagctcag cgatgccctg 2100
cgggacaaca tcctgcccga gcttggggtg cggtttgaag accacgaagg actgcccaca 2160
gtggtgaaac tggtagacag aaacacctta ttaaaagaga gagaagaaaa gagacgggtt 2220
gaagaggaga agaggaagaa gaaagaggag gcggcccgga ggaaacagga acaagaaggt 2280
ctgcccacac atgacatgga gggcaaagag ctcagcaaag ggcaagccaa gaagctgaag 2340
aagctcttcg aggctcagga gaagctctac aaggaatatc tgcagatggc ccagaatgga 2400
agcttccagt ga                                                     2412

<210> 24
<211> 50
<212> DNA
<213> Homo sapiens

<400> 24
ggccagccct gcaggctcca agcaagtcct acatctcttt tgatatcttg            50

<210> 25
<211> 16
<212> PRT
<213> Homo sapiens

<400> 25
Gly Gln Pro Cys Arg Leu Gln Ala Ser Pro Thr Ser Leu Leu Ile Ser
 1               5                  10                  15      


<210> 26
<211> 50
<212> DNA
<213> Homo sapiens

<400> 26
cagaaagccc ttcaagaagg ggaaggccta ctttgaaaac gactgctggg            50

<210> 27
<211> 11
<212> PRT
<213> Homo sapiens

<400> 27
Gln Lys Ala Leu Gln Glu Gly Glu Gly Leu Leu
 1               5                  10      


<210> 28
<211> 50
<212> DNA
<213> Homo sapiens

<400> 28
gcttcaatat gagaagttct tgaatctttt atgacaagaa gacagcaatt            50

<210> 29
<211> 10
<212> PRT
<213> Homo sapiens

<400> 29
Leu Gln Tyr Glu Lys Phe Leu Asn Leu Leu
 1               5                  10  


<210> 30
<211> 50
<212> DNA
<213> Homo sapiens

<400> 30
ttacaacagc ctcaccagga acaaggtcct acatctcttt tgatatcttg            50

<210> 31
<211> 13
<212> PRT
<213> Homo sapiens

<400> 31
Tyr Asn Ser Leu Thr Arg Asn Lys Val Leu His Leu Phe
 1               5                  10              


<210> 32
<211> 50
<212> DNA
<213> Homo sapiens

<400> 32
gtcctggccg tgcccttggg gaaaggccta ctttgaaaac gactgctggg            50

<210> 33
<211> 16
<212> PRT
<213> Homo sapiens

<400> 33
Ser Trp Pro Cys Pro Trp Gly Lys Ala Tyr Phe Glu Asn Asp Cys Trp
 1               5                  10                  15      


<210> 34
<211> 50
<212> DNA
<213> Homo sapiens

<400> 34
ggcccggagg aaacaggaac aagaaggtct gcccacacat gacatggagg            50

<210> 35
<211> 16
<212> PRT
<213> Homo sapiens

<400> 35
Ala Arg Arg Lys Gln Glu Gln Glu Gly Leu Pro Thr His Asp Met Glu
 1               5                  10                  15      


<210> 36
<211> 229
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro
225                 


<210> 37
<211> 687
<212> DNA
<213> Homo sapiens

<400> 37
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggaag tgttcatacc tcaagatggg aaaaaggtga cgtggtattg ctgtgggcca 420
accgtctatg acgcatctca catggggcac gccaggtcct acatctcttt tgatatcttg 480
agaagagtgt tgaaggatta cttcaaattt gatgtctttt attgcatgaa cattacggat 540
attgatgaca agatcatcaa gagggcccgg cagaaccacc tgttcgagca gtatcgggag 600
aagaggcctg aagcggcaca gctcttggag gatgttcagg ccgccctgaa gccattttca 660
gtaaaattaa atgagaccac ggatccc                                     687

<210> 38
<211> 444
<212> PRT
<213> Homo sapiens

<400> 38
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro
385                 390                 395                 400 
Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp
                405                 410                 415     
Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser
            420                 425                 430         
Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp
        435                 440                 


<210> 39
<211> 1332
<212> DNA
<213> Homo sapiens

<400> 39
atggcagatt cctccgggca gcaggctcct gactacaggt ccattctgag cattagtgac 60
gaggcagcca gggcacaagc cctgaacgag cacctcagca cgcgtagcta tgtccagggg 120
tactcactgt cccaggcaga cgtggacgcg ttcaggcagc tctcggcccc gcccgctgac 180
ccccagctct tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtagcccc 240
tgtggcaaag gccagccctg caggctccaa gcaagcaaag gccggcgtgt gcagccccag 300
tggtcccctc ctgctgggac ccagccatgc agactccacc tttacaacag cctcaccagg 360
aacaaggaag tgttcatacc tcaagatggg aaaaaggtga cgtggtattg ctgtgggcca 420
accgtctatg acgcatctca catggggcac gccaggtcct acatctcttt tgatatcttg 480
agaagagtgt tgaaggatta cttcaaattt gatgtctttt attgcatgaa cattacggat 540
attgatgaca agatcatcaa gagggcccgg cagaaccacc tgttcgagca gtatcgggag 600
aagaggcctg aagcggcaca gctcttggag gatgttcagg ccgccctgaa gccattttca 660
gtaaaattaa atgagaccac ggatcccgat aaaaagcaga tgctcgaacg gattcagcac 720
gcagtgcagc ttgccacaga gccacttgag aaagctgtgc agtccagact cacgggagag 780
gaagtcaaca gctgtgtgga ggtgttgctg gaagaagcca aggatttgct ctctgactgg 840
ctggattcta cacttggctg tgatgtcact gacaattcca tcttctccaa gctgcccaag 900
ttctgggagg gggacttcca cagagacatg gaagctctga atgttctccc tccagatgtc 960
ttaacccggg ttagtgagta tgtgccagaa attgtgaact ttgtccagaa gattgtggac 1020
aacggttacg gctatgtctc caatgggtct gtctactttg atacagcgaa gtttgcttct 1080
agcgagaagc actcctatgg gaagctggtg cctgaggccg ttggagatca gaaagccctt 1140
caagaagggg aaggtgacct gagcatctct gcagaccgcc tgagtgagaa gcgctctccc 1200
aacgactttg ccttatggaa ggcctctaag cccggagaac cgtcctggcc gtgcccttgg 1260
ggaaagggtc gtccgggctg gcatatcgag tgctcggcca tggcaggcac cctcctaggg 1320
gcttcgatgg ac                                                     1332

<210> 40
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 40
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Asp Ser Ser Gly Gln Gln Ala Pro
            20                  25                  30          
Asp Tyr Arg Ser Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln
        35                  40                  45              
Ala Leu Asn Glu His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser
    50                  55                  60                  
Leu Ser Gln Ala Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro
65                  70                  75                  80  
Ala Asp Pro Gln Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu
                85                  90                  95      
Ala Leu Leu Gly Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln
            100                 105                 110         
Ala Ser Lys Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly
        115                 120                 125             
Thr Gln Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys
    130                 135                 140                 
Glu Val Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys
145                 150                 155                 160 
Gly Pro Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr
                165                 170                 175     
Ile Ser Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe
            180                 185                 190         
Asp Val Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile
        195                 200                 205             
Lys Arg Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg
    210                 215                 220                 
Pro Glu Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro
225                 230                 235                 240 
Phe Ser Val Lys Leu Asn Glu Thr Thr Asp Pro Leu Glu
                245                 250             


<210> 41
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 41
Met Gly Ser Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser
 1               5                  10                  15      
Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu
            20                  25                  30          
His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala
        35                  40                  45              
Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln
    50                  55                  60                  
Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly
65                  70                  75                  80  
Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly
                85                  90                  95      
Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys
            100                 105                 110         
Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile
        115                 120                 125             
Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val
    130                 135                 140                 
Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp
145                 150                 155                 160 
Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr
                165                 170                 175     
Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg
            180                 185                 190         
Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala
        195                 200                 205             
Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys
    210                 215                 220                 
Leu Asn Glu Thr Thr Asp Pro Leu Glu Gly Lys Pro Ile Pro Asn Pro
225                 230                 235                 240 
Leu Leu Gly Leu Asp Ser Thr His His His His His His
                245                 250             


<210> 42
<211> 464
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 42
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr
            20                  25                  30          
Arg Ser Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu
        35                  40                  45              
Asn Glu His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser
    50                  55                  60                  
Gln Ala Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp
65                  70                  75                  80  
Pro Gln Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu
                85                  90                  95      
Leu Gly Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser
            100                 105                 110         
Lys Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln
        115                 120                 125             
Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val
    130                 135                 140                 
Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro
145                 150                 155                 160 
Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser
                165                 170                 175     
Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val
            180                 185                 190         
Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg
        195                 200                 205             
Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu
    210                 215                 220                 
Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser
225                 230                 235                 240 
Val Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu
                245                 250                 255     
Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala
            260                 265                 270         
Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val
        275                 280                 285             
Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr
    290                 295                 300                 
Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys
305                 310                 315                 320 
Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu
                325                 330                 335     
Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val
            340                 345                 350         
Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn
        355                 360                 365             
Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His
    370                 375                 380                 
Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu
385                 390                 395                 400 
Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu
                405                 410                 415     
Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly
            420                 425                 430         
Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His
        435                 440                 445             
Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp
    450                 455                 460                 


<210> 43
<211> 464
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 43
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro
385                 390                 395                 400 
Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp
                405                 410                 415     
Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser
            420                 425                 430         
Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Gly Lys Pro Ile
        435                 440                 445             
Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
    450                 455                 460                 


<210> 44
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 44
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Asp Ser Ser Gly Gln Gln Ala Pro
            20                  25                  30          
Asp Tyr Arg Ser Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln
        35                  40                  45              
Ala Leu Asn Glu His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser
    50                  55                  60                  
Leu Ser Gln Ala Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro
65                  70                  75                  80  
Ala Asp Pro Gln Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu
                85                  90                  95      
Ala Leu Leu Gly Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln
            100                 105                 110         
Ala Ser Pro Thr Ser Leu Leu Ile Ser Leu Glu
        115                 120             


<210> 45
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 45
Met Gly Ser Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser
 1               5                  10                  15      
Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu
            20                  25                  30          
His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala
        35                  40                  45              
Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln
    50                  55                  60                  
Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly
65                  70                  75                  80  
Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Pro Thr
                85                  90                  95      
Ser Leu Leu Ile Ser Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu
            100                 105                 110         
Gly Leu Asp Ser Thr His His His His His His
        115                 120             


<210> 46
<211> 407
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 46
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr
            20                  25                  30          
Arg Ser Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu
        35                  40                  45              
Asn Glu His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser
    50                  55                  60                  
Gln Ala Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp
65                  70                  75                  80  
Pro Gln Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu
                85                  90                  95      
Leu Gly Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser
            100                 105                 110         
Lys Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln
        115                 120                 125             
Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val
    130                 135                 140                 
Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro
145                 150                 155                 160 
Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser
                165                 170                 175     
Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val
            180                 185                 190         
Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg
        195                 200                 205             
Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu
    210                 215                 220                 
Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser
225                 230                 235                 240 
Val Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu
                245                 250                 255     
Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala
            260                 265                 270         
Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val
        275                 280                 285             
Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr
    290                 295                 300                 
Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys
305                 310                 315                 320 
Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu
                325                 330                 335     
Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val
            340                 345                 350         
Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn
        355                 360                 365             
Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His
    370                 375                 380                 
Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu
385                 390                 395                 400 
Gln Glu Gly Glu Gly Leu Leu
                405         


<210> 47
<211> 407
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 47
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln
        115                 120                 125             
Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp
    130                 135                 140                 
Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu
145                 150                 155                 160 
Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met
                165                 170                 175     
Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn
            180                 185                 190         
His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu
        195                 200                 205             
Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn
    210                 215                 220                 
Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His
225                 230                 235                 240 
Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg
                245                 250                 255     
Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu
            260                 265                 270         
Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp
        275                 280                 285             
Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly
    290                 295                 300                 
Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val
305                 310                 315                 320 
Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln
                325                 330                 335     
Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr
            340                 345                 350         
Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys
        355                 360                 365             
Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu
    370                 375                 380                 
Gly Leu Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
385                 390                 395                 400 
Thr His His His His His His
                405         


<210> 48
<211> 569
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 48
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Asp Ser Ser Gly Gln Gln Ala Pro
            20                  25                  30          
Asp Tyr Arg Ser Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln
        35                  40                  45              
Ala Leu Asn Glu His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser
    50                  55                  60                  
Leu Ser Gln Ala Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro
65                  70                  75                  80  
Ala Asp Pro Gln Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu
                85                  90                  95      
Ala Leu Leu Gly Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln
            100                 105                 110         
Ala Ser Lys Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly
        115                 120                 125             
Thr Gln Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys
    130                 135                 140                 
Glu Val Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys
145                 150                 155                 160 
Gly Pro Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr
                165                 170                 175     
Ile Ser Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe
            180                 185                 190         
Asp Val Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile
        195                 200                 205             
Lys Arg Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg
    210                 215                 220                 
Pro Glu Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro
225                 230                 235                 240 
Phe Ser Val Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met
                245                 250                 255     
Leu Glu Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu
            260                 265                 270         
Lys Ala Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val
        275                 280                 285             
Glu Val Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp
    290                 295                 300                 
Ser Thr Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu
305                 310                 315                 320 
Pro Lys Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn
                325                 330                 335     
Val Leu Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu
            340                 345                 350         
Ile Val Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val
        355                 360                 365             
Ser Asn Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu
    370                 375                 380                 
Lys His Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys
385                 390                 395                 400 
Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu
                405                 410                 415     
Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys
            420                 425                 430         
Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly
        435                 440                 445             
Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser
    450                 455                 460                 
Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp
465                 470                 475                 480 
Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val
                485                 490                 495     
Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met
            500                 505                 510         
Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys
        515                 520                 525             
His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys
    530                 535                 540                 
Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr
545                 550                 555                 560 
Glu Lys Phe Leu Asn Leu Leu Leu Glu
                565                 


<210> 49
<211> 569
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 49
Met Gly Ser Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser
 1               5                  10                  15      
Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu
            20                  25                  30          
His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala
        35                  40                  45              
Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln
    50                  55                  60                  
Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly
65                  70                  75                  80  
Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly
                85                  90                  95      
Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys
            100                 105                 110         
Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile
        115                 120                 125             
Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val
    130                 135                 140                 
Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp
145                 150                 155                 160 
Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr
                165                 170                 175     
Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg
            180                 185                 190         
Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala
        195                 200                 205             
Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys
    210                 215                 220                 
Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile
225                 230                 235                 240 
Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln
                245                 250                 255     
Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu
            260                 265                 270         
Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly
        275                 280                 285             
Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp
    290                 295                 300                 
Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro
305                 310                 315                 320 
Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe
                325                 330                 335     
Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser
            340                 345                 350         
Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr
        355                 360                 365             
Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu
    370                 375                 380                 
Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg
385                 390                 395                 400 
Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro
                405                 410                 415     
Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu
            420                 425                 430         
Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His
        435                 440                 445             
Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala
    450                 455                 460                 
Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu
465                 470                 475                 480 
His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu
                485                 490                 495     
Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg
            500                 505                 510         
Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp
        515                 520                 525             
Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu
    530                 535                 540                 
Asn Leu Leu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
545                 550                 555                 560 
Asp Ser Thr His His His His His His
                565                 


<210> 50
<211> 147
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 50
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr
            20                  25                  30          
Arg Ser Ile Leu Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu
        35                  40                  45              
Asn Glu His Leu Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser
    50                  55                  60                  
Gln Ala Asp Val Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp
65                  70                  75                  80  
Pro Gln Leu Phe His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu
                85                  90                  95      
Leu Gly Ser Pro Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser
            100                 105                 110         
Lys Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln
        115                 120                 125             
Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Val Leu
    130                 135                 140                 
His Leu Phe
145         


<210> 51
<211> 147
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 51
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu
 1               5                  10                  15      
Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu
            20                  25                  30          
Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val
        35                  40                  45              
Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe
    50                  55                  60                  
His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro
65                  70                  75                  80  
Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg
                85                  90                  95      
Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu
            100                 105                 110         
His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Val Leu His Leu Phe Gly
        115                 120                 125             
Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His
    130                 135                 140                 
His His His
145         


<210> 52
<211> 696
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 52
ggatccgcag actcaagcgg acaacaagca ccggattatc gtagcattct gagcatcagc 60
gacgaagcag cacgtgccca agccctgaac gaacatctgt ctacccgctc ttatgtccag 120
ggttatagcc tgtcacaagc cgacgttgac gcctttcgcc aactgtcagc acctccagcc 180
gatccacaac tgtttcatgt ggcccgttgg tttcgccata ttgaagccct gctgggttct 240
ccatgtggta aaggtcagcc gtgtcgcctg caagcttcca aaggacgccg tgttcaacct 300
caatggtcac cgcctgccgg tactcaacct tgccgcctgc atctgtataa cagcctgacc 360
cgtaacaaag aagtgtttat ccctcaagac ggtaaaaaag tgacgtggta ttgctgtggt 420
ccaaccgtgt atgacgcttc tcacatgggt catgctcgct cctatatcag cttcgacatc 480
ctgcgtcgtg tactgaaaga ctatttcaaa ttcgatgtgt tctattgtat gaatatcacc 540
gatatcgacg acaaaatcat caaacgtgcc cgccagaatc acctgtttga gcagtatcgt 600
gaaaaacgcc ctgaggcagc ccaactgctg gaagatgtcc aggcagcact gaaacctttt 660
agcgtgaaac tgaatgagac aaccgacccg ctcgag                           696

<210> 53
<211> 1341
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 53
gcagacagct cgggccaaca agcaccagac taccgcagca tcctgagcat tagcgatgaa 60
gccgctcgcg cgcaagcatt gaacgagcat ctgagcaccc gttcctacgt ccaaggttat 120
agcctgagcc aggccgacgt tgacgcattc cgtcagctga gcgcgccacc ggctgatccg 180
caactgtttc acgtcgcacg ttggtttcgc catatcgaag cgctgctggg ctccccgtgt 240
ggtaaaggtc agccgtgtcg tctgcaggcg agcaaaggcc gtcgtgtgca gccgcagtgg 300
tccccgccag cgggtaccca accgtgccgc ctgcacctgt acaatagcct gacgcgtaac 360
aaagaggtct ttatcccgca agatggtaag aaggtgacgt ggtattgctg cggtccgacg 420
gtgtacgatg cgtcccacat gggccacgca cgcagctata tcagctttga tattctgcgt 480
cgtgtgttga aggattactt caagttcgat gtcttttact gcatgaatat caccgatatt 540
gacgacaaga tcatcaaacg tgcacgtcag aatcacctgt tcgaacaata tcgcgagaag 600
cgtccggagg cggcacagtt gctggaggac gttcaggccg ctctgaagcc gttctctgtg 660
aagctgaatg aaacgaccga cccggacaaa aagcaaatgc tggaacgtat ccagcacgcc 720
gtgcaactgg cgaccgagcc gctggagaaa gccgtccaga gccgcctgac gggcgaagaa 780
gttaatagct gtgtggaggt gctgttggaa gaggcgaagg atctgctgag cgactggctg 840
gacagcacct tgggctgcga cgtgaccgac aacagcattt tctctaagct gccgaagttt 900
tgggagggtg atttccatcg cgacatggag gcgctgaacg ttttgcctcc ggatgttctg 960
actcgtgttt ctgagtacgt tccggagatt gttaactttg ttcagaaaat tgtcgataat 1020
ggttacggtt acgtcagcaa cggcagcgtg tatttcgata ccgcgaaatt tgcgagcagc 1080
gagaaacaca gctatggtaa actggtcccg gaagcagtag gcgatcagaa agcgctgcaa 1140
gaaggtgagg gcgacttgtc tatttccgcg gatcgcctga gcgaaaagcg tagcccgaac 1200
gacttcgccc tgtggaaagc tagcaaaccg ggtgagccta gctggccgtg cccgtggggt 1260
aaaggtcgtc cgggttggca tattgaatgt tcggcgatgg cgggcaccct gctgggtgcc 1320
tctatggact aatgactcga g                                           1341

<210> 54
<211> 306
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 54
ggatccgccg attcaagtgg ccaacaagct cctgactatc gctctatcct gtccatttcc 60
gatgaggccg ctcgtgccca agcactgaat gagcacctgt ctactcgctc ttatgtccag 120
gggtattctc tgagccaagc agacgtggac gcctttcgcc agctgtcagc tccacctgcc 180
gaccctcaac tgttccatgt tgctcgctgg ttccgtcaca ttgaagcact gctgggaagt 240
ccttgtggca aaggacaacc atgccgcctg caagcatctc ctacaagcct gctgattagc 300
ctcgag                                                            306

<210> 55
<211> 1170
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 55
gcagacagct cgggccaaca agcaccagac taccgcagca tcctgagcat ttctgatgag 60
gcggctcgcg cgcaggcgct gaatgaacac ttgtccaccc gtagctacgt ccagggctat 120
tctctgtctc aggcagatgt cgatgcattt cgccaactga gcgcaccgcc agcggacccg 180
cagttgttcc atgtggcgcg ttggtttcgt catattgaag cgctgctggg tagcccgtgc 240
ggtaaaggtc aaccgtgccg tctgcaagcg agcaaaggtc gccgtgtcca accgcagtgg 300
agccctccgg ctggtaccca accgtgtcgc ctgcacctgt acaacagcct gacccgtaac 360
aaagaggtgt tcattccgca ggacggcaaa aaggttacgt ggtattgctg tggccctacg 420
gtttacgatg cgtcgcacat gggtcacgcc cgttcctaca tcagctttga catcctgcgt 480
cgtgtgctga aagactactt caaattcgac gtgttctatt gtatgaatat caccgatatt 540
gatgataaga tcattaaacg tgctcgtcag aaccacctgt ttgagcaata tcgtgagaag 600
cgtccggagg ccgctcagct gctggaggac gtacaggcag cgttgaagcc gttctccgtt 660
aaactgaacg aaacgaccga tccggataag aagcaaatgc tggaacgcat tcagcatgcc 720
gttcaactgg cgaccgagcc gctggaaaaa gcagttcaga gccgcctgac gggtgaagaa 780
gtcaacagct gcgtggaagt gctgttggaa gaggccaagg atctgctgag cgattggctg 840
gacagcaccc tgggttgcga cgtgacggat aatagcattt tcagcaaact gccgaagttc 900
tgggagggtg acttccaccg cgacatggag gcgttgaacg ttctgccacc ggacgtcttg 960
acccgtgtta gcgagtacgt gccggagatc gtgaattttg tccagaagat cgttgacaat 1020
ggctacggct acgtcagcaa tggttccgtc tattttgata ctgccaaatt tgccagcagc 1080
gaaaaacata gctatggtaa gctggttccg gaagcggtgg gcgaccagaa ggcgttgcaa 1140
gagggtgagg gcctgctgta atgactcgag                                  1170

<210> 56
<211> 1644
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 56
ggatccgcag actcaagcgg acaacaagca ccggattatc gtagcattct gagcatcagc 60
gacgaagcag cacgtgccca agccctgaac gaacatctgt ctacccgctc ttatgtccag 120
ggttatagcc tgtcacaagc cgacgttgac gcctttcgcc aactgtcagc acctccagcc 180
gatccacaac tgtttcatgt ggcccgttgg tttcgccata ttgaagccct gctgggttct 240
ccatgtggta aaggtcagcc gtgtcgcctg caagcttcca aaggacgccg tgttcaacct 300
caatggtcac cgcctgccgg tactcaacct tgccgcctgc atctgtataa cagcctgacc 360
cgtaacaaag aagtgtttat ccctcaagac ggtaaaaaag tgacgtggta ttgctgtggt 420
ccaaccgtgt atgacgcttc tcacatgggt catgctcgct cctatatcag cttcgacatc 480
ctgcgtcgtg tactgaaaga ctatttcaaa ttcgatgtgt tctattgtat gaatatcacc 540
gatatcgacg acaaaatcat caaacgtgcc cgccagaatc acctgtttga gcagtatcgt 600
gaaaaacgcc ctgaggcagc ccaactgctg gaagatgtcc aggcagcact gaaacctttt 660
agcgtgaaac tgaatgagac aaccgaccct gacaaaaaac aaatgctgga gcgtattcag 720
catgctgttc agctggcaac agaaccactg gaaaaagcgg ttcagagtcg tctgactggt 780
gaagaagtga actcctgtgt agaggtcctg ctggaagaag caaaagatct gctgtcggac 840
tggctggatt ctacactggg ttgtgatgtg accgataaca gcatcttcag caaactgccg 900
aaattttggg aaggcgattt ccaccgtgat atggaggctc tgaatgttct gcctccggat 960
gttctgacac gtgttagcga atatgtgccg gagattgtga acttcgtaca gaaaatcgtg 1020
gacaatggct atggttatgt gtctaacggc agcgtgtatt tcgatacagc gaaattcgcc 1080
agtagcgaga aacattccta tggcaaactg gttccggaag ccgttggaga tcagaaagca 1140
ctgcaagaag gtgaaggcga tctgagcatt agtgccgatc gtctgtcgga aaaacgttcc 1200
ccgaatgact tcgccctgtg gaaagcctct aaaccgggtg aaccttcatg gccatgccct 1260
tggggcaaag gccgtccagg ttggcacatt gaatgctcgg caatggcagg aacactgctg 1320
ggagcttcta tggatatcca tggtggcggt tttgatctgc gtttcccaca ccacgacaat 1380
gaactggcac agtctgaagc ctattttgag aacgattgtt gggtccgtta tttcctgcac 1440
accggtcatc tgactattgc tggctgtaaa atgagcaaat ccctgaaaaa ctttatcacc 1500
atcaaagacg ccctgaaaaa acacagtgcc cgtcagctgc gtctggcatt cctgatgcat 1560
tcttggaaag acacactgga ctatagcagc aacacaatgg aatctgcgct gcagtatgag 1620
aaattcctga atctgctgct cgag                                        1644

<210> 57
<211> 390
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 57
gcagacagct cgggccaaca agcaccagac taccgcagca tcttgagcat ctccgatgaa 60
gcggcacgtg cgcaagcgct gaacgagcat ctgtctaccc gtagctatgt ccagggctat 120
agcctgagcc aggctgatgt tgatgccttc cgtcagctga gcgcgccacc ggcggacccg 180
caactgtttc acgtggcgcg ctggttccgt catattgagg ccttgctggg tagcccgtgc 240
ggtaaaggtc agccgtgccg cctgcaggcc agcaaaggtc gccgtgtgca gccgcaatgg 300
tccccgcctg ctggcaccca gccgtgtcgt ctgcacttgt acaatagcct gacgcgtaac 360
aaggttctgc acctgtttta atgactcgag                                  390

<210> 58
<211> 656
<212> PRT
<213> Homo sapiens

<400> 58
Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln
 1               5                  10                  15      
Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln
            20                  25                  30          
Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu
        35                  40                  45              
Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln
    50                  55                  60                  
His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser
65                  70                  75                  80  
Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu
                85                  90                  95      
Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys
            100                 105                 110         
Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu
        115                 120                 125             
Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp
    130                 135                 140                 
Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val
145                 150                 155                 160 
Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val
                165                 170                 175     
Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly
            180                 185                 190         
Lys Leu Val Pro Glu Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala
        195                 200                 205             
Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr
    210                 215                 220                 
Leu Thr His Met Leu Lys Ile Phe Gly Ala Ala Val Gly Asp Gln Lys
225                 230                 235                 240 
Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu
                245                 250                 255     
Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys
            260                 265                 270         
Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly
        275                 280                 285             
Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser
    290                 295                 300                 
Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp
305                 310                 315                 320 
Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val
                325                 330                 335     
Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met
            340                 345                 350         
Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys
        355                 360                 365             
His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys
    370                 375                 380                 
Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr
385                 390                 395                 400 
Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg
                405                 410                 415     
Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu
            420                 425                 430         
Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys
        435                 440                 445             
Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg
    450                 455                 460                 
Ala Leu Val Ser Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly
465                 470                 475                 480 
Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu
                485                 490                 495     
Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu
            500                 505                 510         
Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn
        515                 520                 525             
Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro
    530                 535                 540                 
Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu
545                 550                 555                 560 
Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala
                565                 570                 575     
Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys
            580                 585                 590         
Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys
        595                 600                 605             
Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu
    610                 615                 620                 
Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu
625                 630                 635                 640 
Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln
                645                 650                 655     


<210> 59
<211> 1971
<212> DNA
<213> Homo sapiens

<400> 59
atgaacatta cggatattga tgacaagatc atcaagaggg cccggcagaa ccacctgttc 60
gagcagtatc gggagaagag gcctgaagcg gcacagctct tggaggatgt tcaggccgcc 120
ctgaagccat tttcagtaaa attaaatgag accacggatc ccgataaaaa gcagatgctc 180
gaacggattc agcacgcagt gcagcttgcc acagagccac ttgagaaagc tgtgcagtcc 240
agactcacgg gagaggaagt caacagctgt gtggaggtgt tgctggaaga agccaaggat 300
ttgctctctg actggctgga ttctacactt ggctgtgatg tcactgacaa ttccatcttc 360
tccaagctgc ccaagttctg ggagggggac ttccacagag acatggaagc tctgaatgtt 420
ctccctccag atgtcttaac ccgggttagt gagtatgtgc cagaaattgt gaactttgtc 480
cagaagattg tggacaacgg ttacggctat gtctccaatg ggtctgtcta ctttgataca 540
gcgaagtttg cttctagcga gaagcactcc tatgggaagc tggtgcctga ggccgttgga 600
gatcagaaag cccttcaaga aggggaaggt gacctgagca tctctgcaga ccgcctgagt 660
gagaagcgct ctcccaacga ctttgcctta tggaaggcct ctaagcccgg agaaccgtcc 720
tggccgtgcc cttggggaaa gggtcgtccg ggctggcata tcgagtgctc ggccatggca 780
ggcaccctcc taggggcttc gatggacatt cacggaggtg ggttcgacct ccggttcccc 840
caccatgaca atgagctggc acagtcggag gcctactttg aaaacgactg ctgggtcagg 900
tacttcctgc acacaggcca cctgaccatt gcaggctgca aaatgtcaaa gtcactaaaa 960
aacttcatca ccattaaaga tgccttgaaa aagcactcag cacggcagtt gcggctggcc 1020
ttcctcatgc actcgtggaa ggacaccctg gactactcca gcaacaccat ggagtcagcg 1080
cttcaatatg agaagttctt gaatgagttt ttcttaaatg tgaaagatat ccttcgcgct 1140
cctgttgaca tcactggtca gtttgagaag tggggagaag aagaagcaga actgaataag 1200
aacttttatg acaagaagac agcaattcac aaagccctct gtgacaatgt tgacacccgc 1260
accgtcatgg aagagatgcg ggccttggtc agtcagtgca acctctatat ggcagcccgg 1320
aaagccgtga ggaagaggcc caaccaggct ctgctggaga acatcgccct gtacctcacc 1380
catatgctga agatctttgg ggccgtagaa gaggacagct ccctgggatt cccggtcgga 1440
gggcctggaa ccagcctcag tctcgaggcc acagtcatgc cctaccttca ggtgttatca 1500
gaattccgag aaggagtgcg gaagattgcc cgagagcaaa aagtccctga gattctgcag 1560
ctcagcgatg ccctgcggga caacatcctg cccgagcttg gggtgcggtt tgaagaccac 1620
gaaggactgc ccacagtggt gaaactggta gacagaaaca ccttattaaa agagagagaa 1680
gaaaagagac gggttgaaga ggagaagagg aagaagaaag aggaggcggc ccggaggaaa 1740
caggaacaag aagcagcaaa gctggccaag atgaagattc cccccagtga gatgttcttg 1800
tcagaaaccg acaaatactc caagtttgat gaaaatggtc tgcccacaca tgacatggag 1860
ggcaaagagc tcagcaaagg gcaagccaag aagctgaaga agctcttcga ggctcaggag 1920
aagctctaca aggaatatct gcagatggcc cagaatggaa gcttccagtg a          1971

<210> 60
<211> 406
<212> PRT
<213> Homo sapiens

<400> 60
Met Ser Pro Met Gly Leu Ser Thr Leu Ile Gln Arg Ser Leu Leu Leu
 1               5                  10                  15      
Ala Arg Ser Thr Pro Met Gly Ser Trp Cys Leu Arg Pro Leu Glu Ile
            20                  25                  30          
Arg Lys Pro Phe Lys Lys Gly Lys Ala Tyr Phe Glu Asn Asp Cys Trp
        35                  40                  45              
Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys
    50                  55                  60                  
Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys
65                  70                  75                  80  
Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp
                85                  90                  95      
Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln
            100                 105                 110         
Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu
        115                 120                 125             
Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu
    130                 135                 140                 
Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His
145                 150                 155                 160 
Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met
                165                 170                 175     
Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala
            180                 185                 190         
Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr
        195                 200                 205             
Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser
    210                 215                 220                 
Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala
225                 230                 235                 240 
Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val
                245                 250                 255     
Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser
            260                 265                 270         
Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu
        275                 280                 285             
Asp His Glu Gly Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr
    290                 295                 300                 
Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg
305                 310                 315                 320 
Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala
                325                 330                 335     
Lys Leu Ala Lys Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu
            340                 345                 350         
Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp
        355                 360                 365             
Met Glu Gly Lys Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys
    370                 375                 380                 
Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala
385                 390                 395                 400 
Gln Asn Gly Ser Phe Gln
                405     


<210> 61
<211> 1221
<212> DNA
<213> Homo sapiens

<400> 61
atgtctccaa tgggtctgtc tactttgata cagcgaagtt tgcttctagc gagaagcact 60
cctatgggaa gctggtgcct gaggccgttg gagatcagaa agcccttcaa gaaggggaag 120
gcctactttg aaaacgactg ctgggtcagg tacttcctgc acacaggcca cctgaccatt 180
gcaggctgca aaatgtcaaa gtcactaaaa aacttcatca ccattaaaga tgccttgaaa 240
aagcactcag cacggcagtt gcggctggcc ttcctcatgc actcgtggaa ggacaccctg 300
gactactcca gcaacaccat ggagtcagcg cttcaatatg agaagttctt gaatgagttt 360
ttcttaaatg tgaaagatat ccttcgcgct cctgttgaca tcactggtca gtttgagaag 420
tggggagaag aagaagcaga actgaataag aacttttatg acaagaagac agcaattcac 480
aaagccctct gtgacaatgt tgacacccgc accgtcatgg aagagatgcg ggccttggtc 540
agtcagtgca acctctatat ggcagcccgg aaagccgtga ggaagaggcc caaccaggct 600
ctgctggaga acatcgccct gtacctcacc catatgctga agatctttgg ggccgtagaa 660
gaggacagct ccctgggatt cccggtcgga gggcctggaa ccagcctcag tctcgaggcc 720
acagtcatgc cctaccttca ggtgttatca gaattccgag aaggagtgcg gaagattgcc 780
cgagagcaaa aagtccctga gattctgcag ctcagcgatg ccctgcggga caacatcctg 840
cccgagcttg gggtgcggtt tgaagaccac gaaggactgc ccacagtggt gaaactggta 900
gacagaaaca ccttattaaa agagagagaa gaaaagagac gggttgaaga ggagaagagg 960
aagaagaaag aggaggcggc ccggaggaaa caggaacaag aagcagcaaa gctggccaag 1020
atgaagattc cccccagtga gatgttcttg tcagaaaccg acaaatactc caagtttgat 1080
gaaaatggtc tgcccacaca tgacatggag ggcaaagagc tcagcaaagg gcaagccaag 1140
aagctgaaga agctcttcga ggctcaggag aagctctaca aggaatatct gcagatggcc 1200
cagaatggaa gcttccagtg a                                           1221

<210> 62
<211> 234
<212> PRT
<213> Homo sapiens

<400> 62
Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala
 1               5                  10                  15      
Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn
            20                  25                  30          
Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu
        35                  40                  45              
Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu
    50                  55                  60                  
Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe
65                  70                  75                  80  
Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile
                85                  90                  95      
Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly
            100                 105                 110         
Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys Leu Val
        115                 120                 125             
Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu
    130                 135                 140                 
Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys Gln Glu
145                 150                 155                 160 
Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser Glu Met
                165                 170                 175     
Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn Gly Leu
            180                 185                 190         
Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln Ala Lys
        195                 200                 205             
Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys Glu Tyr
    210                 215                 220                 
Leu Gln Met Ala Gln Asn Gly Ser Phe Gln
225                 230                 


<210> 63
<211> 705
<212> DNA
<213> Homo sapiens

<400> 63
atggaagaga tgcgggcctt ggtcagtcag tgcaacctct atatggcagc ccggaaagcc 60
gtgaggaaga ggcccaacca ggctctgctg gagaacatcg ccctgtacct cacccatatg 120
ctgaagatct ttggggccgt agaagaggac agctccctgg gattcccggt cggagggcct 180
ggaaccagcc tcagtctcga ggccacagtc atgccctacc ttcaggtgtt atcagaattc 240
cgagaaggag tgcggaagat tgcccgagag caaaaagtcc ctgagattct gcagctcagc 300
gatgccctgc gggacaacat cctgcccgag cttggggtgc ggtttgaaga ccacgaagga 360
ctgcccacag tggtgaaact ggtagacaga aacaccttat taaaagagag agaagaaaag 420
agacgggttg aagaggagaa gaggaagaag aaagaggagg cggcccggag gaaacaggaa 480
caagaagcag caaagctggc caagatgaag attcccccca gtgagatgtt cttgtcagaa 540
accgacaaat actccaagtt tgatgaaaat ggtctgccca cacatgacat ggagggcaaa 600
gagctcagca aagggcaagc caagaagctg aagaagctct tcgaggctca ggagaagctc 660
tacaaggaat atctgcagat ggcccagaat ggaagcttcc agtga                 705

<210> 64
<211> 50
<212> DNA
<213> Homo sapiens

<400> 64
ggccagccct gcaggctcca agcaagtcct acatctcttt tgatatcttg            50

<210> 65
<211> 50
<212> DNA
<213> Homo sapiens

<400> 65
cagaaagccc ttcaagaagg ggaaggccta ctttgaaaac gactgctggg            50

<210> 66
<211> 16
<212> PRT
<213> Homo sapiens

<400> 66
Arg Lys Pro Phe Lys Lys Gly Lys Ala Tyr Phe Glu Asn Asp Cys Trp
 1               5                  10                  15      


<210> 67
<211> 50
<212> DNA
<213> Homo sapiens

<400> 67
gcttcaatat gagaagttct tgaatctttt atgacaagaa gacagcaatt            50

<210> 68
<211> 426
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 68
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ser Pro Met Gly Leu Ser Thr Leu Ile Gln Arg
            20                  25                  30          
Ser Leu Leu Leu Ala Arg Ser Thr Pro Met Gly Ser Trp Cys Leu Arg
        35                  40                  45              
Pro Leu Glu Ile Arg Lys Pro Phe Lys Lys Gly Lys Ala Tyr Phe Glu
    50                  55                  60                  
Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile
65                  70                  75                  80  
Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys
                85                  90                  95      
Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu
            100                 105                 110         
Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu
        115                 120                 125             
Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val
    130                 135                 140                 
Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys
145                 150                 155                 160 
Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys
                165                 170                 175     
Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val
            180                 185                 190         
Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala
        195                 200                 205             
Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn
    210                 215                 220                 
Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu
225                 230                 235                 240 
Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu
                245                 250                 255     
Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe
            260                 265                 270         
Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile
        275                 280                 285             
Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly
    290                 295                 300                 
Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys Leu Val
305                 310                 315                 320 
Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu
                325                 330                 335     
Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys Gln Glu
            340                 345                 350         
Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser Glu Met
        355                 360                 365             
Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn Gly Leu
    370                 375                 380                 
Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln Ala Lys
385                 390                 395                 400 
Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys Glu Tyr
                405                 410                 415     
Leu Gln Met Ala Gln Asn Gly Ser Phe Gln
            420                 425     


<210> 69
<211> 426
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 69
Met Ser Pro Met Gly Leu Ser Thr Leu Ile Gln Arg Ser Leu Leu Leu
 1               5                  10                  15      
Ala Arg Ser Thr Pro Met Gly Ser Trp Cys Leu Arg Pro Leu Glu Ile
            20                  25                  30          
Arg Lys Pro Phe Lys Lys Gly Lys Ala Tyr Phe Glu Asn Asp Cys Trp
        35                  40                  45              
Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys
    50                  55                  60                  
Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys
65                  70                  75                  80  
Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp
                85                  90                  95      
Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln
            100                 105                 110         
Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu
        115                 120                 125             
Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu
    130                 135                 140                 
Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His
145                 150                 155                 160 
Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met
                165                 170                 175     
Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala
            180                 185                 190         
Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr
        195                 200                 205             
Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser
    210                 215                 220                 
Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala
225                 230                 235                 240 
Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val
                245                 250                 255     
Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser
            260                 265                 270         
Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu
        275                 280                 285             
Asp His Glu Gly Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr
    290                 295                 300                 
Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg
305                 310                 315                 320 
Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala
                325                 330                 335     
Lys Leu Ala Lys Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu
            340                 345                 350         
Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp
        355                 360                 365             
Met Glu Gly Lys Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys
    370                 375                 380                 
Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala
385                 390                 395                 400 
Gln Asn Gly Ser Phe Gln Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
                405                 410                 415     
Leu Asp Ser Thr His His His His His His
            420                 425     


<210> 70
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal  6xHis (DNA2.0) affinity tag

<400> 70
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn
            20                  25                  30          
Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala
        35                  40                  45              
Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe
    50                  55                  60                  
Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro
65                  70                  75                  80  
Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val
                85                  90                  95      
Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys
            100                 105                 110         
Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu
        115                 120                 125             
Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val
    130                 135                 140                 
Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys
145                 150                 155                 160 
Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg
                165                 170                 175     
Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro
            180                 185                 190         
Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp
        195                 200                 205             
Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys
    210                 215                 220                 
Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu
225                 230                 235                 240 
Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln
                245                 250                 


<210> 71
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis (DNA2.0) affinity tag

<400> 71
Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala
 1               5                  10                  15      
Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn
            20                  25                  30          
Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu
        35                  40                  45              
Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu
    50                  55                  60                  
Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe
65                  70                  75                  80  
Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile
                85                  90                  95      
Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly
            100                 105                 110         
Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys Leu Val
        115                 120                 125             
Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu
    130                 135                 140                 
Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys Gln Glu
145                 150                 155                 160 
Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser Glu Met
                165                 170                 175     
Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn Gly Leu
            180                 185                 190         
Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln Ala Lys
        195                 200                 205             
Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys Glu Tyr
    210                 215                 220                 
Leu Gln Met Ala Gln Asn Gly Ser Phe Gln Gly Lys Pro Ile Pro Asn
225                 230                 235                 240 
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                245                 250                 


<210> 72
<211> 258
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis (Genewiz) affinity tag

<400> 72
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Glu Glu Met Arg Ala Leu Val Ser Gln
            20                  25                  30          
Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn
        35                  40                  45              
Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys
    50                  55                  60                  
Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly
65                  70                  75                  80  
Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu
                85                  90                  95      
Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu
            100                 105                 110         
Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn
        115                 120                 125             
Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro
    130                 135                 140                 
Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu
145                 150                 155                 160 
Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala
                165                 170                 175     
Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys
            180                 185                 190         
Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys
        195                 200                 205             
Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu
    210                 215                 220                 
Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu
225                 230                 235                 240 
Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln
                245                 250                 255     
Leu Glu
        


<210> 73
<211> 258
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis (Genewiz) affinity tag

<400> 73
Met Gly Ser Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr
 1               5                  10                  15      
Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu
            20                  25                  30          
Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala
        35                  40                  45              
Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr
    50                  55                  60                  
Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser
65                  70                  75                  80  
Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro
                85                  90                  95      
Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu
            100                 105                 110         
Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys
        115                 120                 125             
Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg
    130                 135                 140                 
Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys
145                 150                 155                 160 
Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser
                165                 170                 175     
Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn
            180                 185                 190         
Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln
        195                 200                 205             
Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys
    210                 215                 220                 
Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln Leu Glu Gly Lys
225                 230                 235                 240 
Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His
                245                 250                 255     
His His
        


<210> 74
<211> 1227
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized cysteinyl tRNA synthetase
      polynucleotide

<400> 74
agcccgatgg gtctgagcac cctgattcaa cgcagcctgt tgctggcccg cagcacgccg 60
atgggttcgt ggtgcttgcg ccctctggag attcgtaaac cgttcaaaaa gggcaaagca 120
tactttgaga acgactgttg ggtgcgctat ttcttgcaca cgggtcatct gaccatcgcg 180
ggctgtaaga tgtccaagtc cctgaaaaac ttcatcacca ttaaagacgc cctgaaaaag 240
cacagcgcac gtcagctgcg cctggcgttt ctgatgcaca gctggaaaga caccctggac 300
tatagctcta acactatgga aagcgctctg cagtacgaga agttcctgaa cgagtttttc 360
ctgaacgtga aggatattct gcgtgcgccg gttgacatca cgggccagtt cgaaaaatgg 420
ggcgaagaag aggccgagct gaacaagaat ttctacgaca agaaaaccgc gatccataaa 480
gcgttgtgcg ataatgttga tacgcgtacg gtcatggaag agatgcgtgc gctggtatcc 540
caatgcaatc tgtacatggc tgctcgtaaa gcagtgcgta aacgtccgaa tcaggctctg 600
ctggagaata tcgcattgta tttgacccac atgctgaaga tttttggtgc cgtcgaagag 660
gacagcagcc tgggtttccc ggttggtggt ccgggtacca gcctgagcct ggaagcgacc 720
gtgatgccgt acctgcaagt cttgagcgag tttcgtgaag gtgttcgcaa gatcgcacgt 780
gagcaaaagg ttccagagat tctgcagctg tcggatgcgc tgcgcgataa cattctgcca 840
gagctgggcg ttcgctttga ggatcatgaa ggcctgccga ctgtcgtgaa actggtcgat 900
cgtaataccc tgctgaaaga gcgtgaagaa aagcgtcgcg tggaagaaga gaagcgtaaa 960
aagaaagaag aggcggcacg tcgtaagcaa gagcaggaag cggcaaagtt ggcgaaaatg 1020
aaaatcccgc cgagcgaaat gtttctgtct gaaacggata agtattccaa atttgacgag 1080
aacggcttgc cgacccacga catggagggt aaagagctga gcaagggtca ggcgaaaaag 1140
ctgaagaagc tgttcgaagc ccaagagaag ctgtacaaag agtatctgca gatggcgcag 1200
aatggtagct tccaataatg actcgag                                     1227

<210> 75
<211> 711
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized (DNA2.0) cysteinyl tRNA synthetase
      polynucleotide

<400> 75
gaggaaatgc gcgcactggt cagccaatgc aacctgtaca tggcagcgcg caaagccgtc 60
cgtaaacgtc cgaaccaggc actgctggag aatatcgcgc tgtacttgac ccacatgctg 120
aagatctttg gcgctgttga agaggactct tccctgggtt ttccggtggg tggtccgggt 180
acctccctga gcctggaggc gacggtgatg ccgtatttgc aagttctgtc tgagttccgt 240
gaaggcgtcc gcaagattgc gcgtgaacag aaggtgccgg agattctgca gctgagcgac 300
gcactgcgtg ataacatcct gccggagctg ggcgttcgct tcgaggacca tgagggtctg 360
ccaaccgtcg ttaaactggt tgatcgtaat accttgctga aagagcgtga agagaagcgt 420
cgcgtggaag aagagaaacg caagaagaaa gaagaagcgg ctcgtcgtaa acaggagcaa 480
gaagcggcga agctggcgaa gatgaagatt ccgccgagcg agatgttcct gagcgaaacg 540
gataagtata gcaaatttga cgaaaacggc ctgcctactc acgatatgga gggcaaagaa 600
ttgagcaaag gtcaagccaa gaaactgaag aagctgtttg aggcccagga gaaactgtac 660
aaagagtatt tgcaaatggc acagaatggt agcttccagt aatgactcga g          711

<210> 76
<211> 711
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized (Genewiz) cysteinyl tRNA
      synthetase polynucleotide

<400> 76
ggatccgaag agatgcgtgc cctggtttct cagtgtaacc tgtatatggc ggctcgtaaa 60
gcagttcgta aacgcccgaa tcaagcactg ctggagaata ttgccctgta tctgactcac 120
atgctgaaaa tctttggcgc cgtggaagaa gattcaagcc tgggttttcc tgttggtggt 180
ccgggtacga gtctgtctct ggaggcaaca gtaatgcctt atctgcaggt tctgagtgag 240
ttccgtgaag gagtccgtaa aattgcccgt gaacagaaag ttccggagat cctgcaactg 300
tctgatgcac tgcgtgacaa cattctgcct gaactgggag ttcgttttga agatcatgaa 360
gggctgccga ccgttgttaa actggtggac cgtaataccc tgctgaaaga gcgtgaagaa 420
aaacgccgtg tggaggaaga aaaacgtaaa aaaaaagagg aagcggcccg tcgtaaacaa 480
gaacaagaag cagcgaaact ggccaaaatg aaaattccac cgagcgagat gtttctgagt 540
gaaaccgaca aatatagcaa attcgatgaa aacggactgc ctacccatga tatggagggt 600
aaagaactga gcaaagggca ggcgaaaaaa ctgaaaaaac tgttcgaggc ccaagaaaaa 660
ctgtataaag agtatctgca gatggcccag aatggttctt ttcagctcga g          711

<210> 77
<211> 484
<212> PRT
<213> Homo sapiens

<400> 77
Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln Leu Ala Thr
 1               5                  10                  15      
Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly Glu Glu Val
            20                  25                  30          
Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser
        35                  40                  45              
Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp Asn Ser Ile
    50                  55                  60                  
Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His Arg Asp Met
65                  70                  75                  80  
Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg Val Ser Glu
                85                  90                  95      
Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val Asp Asn Gly
            100                 105                 110         
Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe
        115                 120                 125             
Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro Glu Ala Val
    130                 135                 140                 
Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser
145                 150                 155                 160 
Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp
                165                 170                 175     
Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys
            180                 185                 190         
Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu
        195                 200                 205             
Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg Phe
    210                 215                 220                 
Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn
225                 230                 235                 240 
Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala
                245                 250                 255     
Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp
            260                 265                 270         
Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met
        275                 280                 285             
His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser
    290                 295                 300                 
Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys
305                 310                 315                 320 
Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp
                325                 330                 335     
Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr
            340                 345                 350         
Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met
        355                 360                 365             
Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala
    370                 375                 380                 
Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile
385                 390                 395                 400 
Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu
                405                 410                 415     
Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser
            420                 425                 430         
Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg
        435                 440                 445             
Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu
    450                 455                 460                 
Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Val
465                 470                 475                 480 
Arg Phe Glu Asp
                


<210> 78
<211> 1452
<212> DNA
<213> Homo sapiens

<400> 78
aaaaagcaga tgctcgaacg gattcagcac gcagtgcagc ttgccacaga gccacttgag 60
aaagctgtgc agtccagact cacgggagag gaagtcaaca gctgtgtgga ggtgttgctg 120
gaagaagcca aggatttgct ctctgactgg ctggattcta cacttggctg tgatgtcact 180
gacaattcca tcttctccaa gctgcccaag ttctgggagg gggacttcca cagagacatg 240
gaagctctga atgttctccc tccagatgtc ttaacccggg ttagtgagta tgtgccagaa 300
attgtgaact ttgtccagaa gattgtggac aacggttacg gctatgtctc caatgggtct 360
gtctactttg atacagcgaa gtttgcttct agcgagaagc actcctatgg gaagctggtg 420
cctgaggccg ttggagatca gaaagccctt caagaagggg aaggtgacct gagcatctct 480
gcagaccgcc tgagtgagaa gcgctctccc aacgactttg ccttatggaa ggcctctaag 540
cccggagaac cgtcctggcc gtgcccttgg ggaaagggtc gtccgggctg gcatatcgag 600
tgctcggcca tggcaggcac cctcctaggg gcttcgatgg acattcacgg aggtgggttc 660
gacctccggt tcccccacca tgacaatgag ctggcacagt cggaggccta ctttgaaaac 720
gactgctggg tcaggtactt cctgcacaca ggccacctga ccattgcagg ctgcaaaatg 780
tcaaagtcac taaaaaactt catcaccatt aaagatgcct tgaaaaagca ctcagcacgg 840
cagttgcggc tggccttcct catgcactcg tggaaggaca ccctggacta ctccagcaac 900
accatggagt cagcgcttca atatgagaag ttcttgaatg agtttttctt aaatgtgaaa 960
gatatccttc gcgctcctgt tgacatcact ggtcagtttg agaagtgggg agaagaagaa 1020
gcagaactga ataagaactt ttatgacaag aagacagcaa ttcacaaagc cctctgtgac 1080
aatgttgaca cccgcaccgt catggaagag atgcgggcct tggtcagtca gtgcaacctc 1140
tatatggcag cccggaaagc cgtgaggaag aggcccaacc aggctctgct ggagaacatc 1200
gccctgtacc tcacccatat gctgaagatc tttggggccg tagaagagga cagctccctg 1260
ggattcccgg tcggagggcc tggaaccagc ctcagtctcg aggccacagt catgccctac 1320
cttcaggtgt tatcagaatt ccgagaagga gtgcggaaga ttgcccgaga gcaaaaagtc 1380
cctgagattc tgcagctcag cgatgccctg cgggacaaca tcctgcccga gcttggggtg 1440
cggtttgaag ac                                                     1452

<210> 79
<211> 11
<212> PRT
<213> Mus musculus

<400> 79
Leu Ala Thr Glu Pro Leu Glu Gln Ala Val Arg
 1               5                  10      


<210> 80
<211> 435
<212> PRT
<213> Mus musculus

<400> 80
Ser Ser Leu Ser Gly Glu Glu Val Asp Ser Lys Val Gln Val Leu Leu
 1               5                  10                  15      
Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Gly Gly
            20                  25                  30          
Ser Glu Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp
        35                  40                  45              
Glu Glu Glu Phe His Lys Asp Met Glu Ala Leu Asn Val Leu Pro Pro
    50                  55                  60                  
Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe
65                  70                  75                  80  
Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Ala Ser Asn Gly Ser
                85                  90                  95      
Val Tyr Phe Asp Thr Ala Lys Phe Ala Ala Ser Glu Lys His Ser Tyr
            100                 105                 110         
Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu
        115                 120                 125             
Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg
    130                 135                 140                 
Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro
145                 150                 155                 160 
Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu
                165                 170                 175     
Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His
            180                 185                 190         
Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala
        195                 200                 205             
Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu
    210                 215                 220                 
His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu
225                 230                 235                 240 
Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg
                245                 250                 255     
Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp
            260                 265                 270         
Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Met
        275                 280                 285             
Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp
    290                 295                 300                 
Ile Thr Gly Gln Phe Glu Lys Trp Glu Ala Glu Glu Val Glu Leu Asn
305                 310                 315                 320 
Lys Asn Phe Tyr Gly Lys Lys Thr Ala Val His Glu Ala Leu Cys Asp
                325                 330                 335     
Asn Ile Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser
            340                 345                 350         
Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Glu Arg Arg Arg Pro
        355                 360                 365             
Asn Arg Ala Leu Leu Glu Asn Ile Ala Met Tyr Leu Thr His Met Leu
    370                 375                 380                 
Lys Ile Phe Gly Ala Ile Glu Glu Glu Ser Pro Leu Gly Phe Pro Val
385                 390                 395                 400 
Gly Gly Pro Gly Thr Asn Leu Asn Leu Glu Ser Thr Val Met Pro Tyr
                405                 410                 415     
Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg
            420                 425                 430         
Glu Lys Lys
        435 


<210> 81
<211> 22
<212> PRT
<213> Mus musculus

<400> 81
Val Leu Glu Val Leu Gln Leu Ser Asp Ala Leu Arg Asp Asp Ile Leu
 1               5                  10                  15      
Pro Glu Leu Gly Val Arg
            20          


<210> 82
<211> 23
<212> PRT
<213> Mus musculus

<400> 82
Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Gly Gly Ser Glu Val Thr
 1               5                  10                  15      
Asp Asn Ser Ile Phe Ser Lys
            20              


<210> 83
<211> 284
<212> PRT
<213> Mus musculus

<400> 83
Leu Pro Lys Phe Trp Glu Glu Glu Phe His Lys Asp Met Glu Ala Leu
 1               5                  10                  15      
Asn Val Leu Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro
            20                  25                  30          
Glu Ile Val Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr
        35                  40                  45              
Ala Ser Asn Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ala Ser
    50                  55                  60                  
Glu Lys His Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln
65                  70                  75                  80  
Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg
                85                  90                  95      
Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser
            100                 105                 110         
Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro
        115                 120                 125             
Gly Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala
    130                 135                 140                 
Ser Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His
145                 150                 155                 160 
Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp
                165                 170                 175     
Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys
            180                 185                 190         
Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys
        195                 200                 205             
Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp
    210                 215                 220                 
Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln
225                 230                 235                 240 
Tyr Glu Lys Phe Met Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu
                245                 250                 255     
Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Glu Ala Glu
            260                 265                 270         
Glu Val Glu Leu Asn Lys Asn Phe Tyr Gly Lys Lys
        275                 280                 


<210> 84
<211> 14
<212> PRT
<213> Mus musculus

<400> 84
Thr Ala Val His Glu Ala Leu Cys Asp Asn Ile Asp Thr Arg
 1               5                  10                  


<210> 85
<211> 468
<212> PRT
<213> Mus musculus

<400> 85
Leu Ala Thr Glu Pro Leu Glu Gln Ala Val Arg Ser Ser Leu Ser Gly
 1               5                  10                  15      
Glu Glu Val Asp Ser Lys Val Gln Val Leu Leu Glu Glu Ala Lys Asp
            20                  25                  30          
Leu Leu Ser Asp Trp Leu Asp Ser Thr Gly Gly Ser Glu Val Thr Asp
        35                  40                  45              
Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Glu Glu Phe His
    50                  55                  60                  
Lys Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg
65                  70                  75                  80  
Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val
                85                  90                  95      
Asp Asn Gly Tyr Gly Tyr Ala Ser Asn Gly Ser Val Tyr Phe Asp Thr
            100                 105                 110         
Ala Lys Phe Ala Ala Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro
        115                 120                 125             
Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu
    130                 135                 140                 
Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe
145                 150                 155                 160 
Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro
                165                 170                 175     
Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala
            180                 185                 190         
Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp
        195                 200                 205             
Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr
    210                 215                 220                 
Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu
225                 230                 235                 240 
Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr
                245                 250                 255     
Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala
            260                 265                 270         
Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr
        275                 280                 285             
Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Met Asn Glu Phe Phe Leu
    290                 295                 300                 
Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe
305                 310                 315                 320 
Glu Lys Trp Glu Ala Glu Glu Val Glu Leu Asn Lys Asn Phe Tyr Gly
                325                 330                 335     
Lys Lys Thr Ala Val His Glu Ala Leu Cys Asp Asn Ile Asp Thr Arg
            340                 345                 350         
Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr
        355                 360                 365             
Met Ala Ala Arg Lys Ala Glu Arg Arg Arg Pro Asn Arg Ala Leu Leu
    370                 375                 380                 
Glu Asn Ile Ala Met Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala
385                 390                 395                 400 
Ile Glu Glu Glu Ser Pro Leu Gly Phe Pro Val Gly Gly Pro Gly Thr
                405                 410                 415     
Asn Leu Asn Leu Glu Ser Thr Val Met Pro Tyr Leu Gln Val Leu Ser
            420                 425                 430         
Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Lys Lys Val Leu
        435                 440                 445             
Glu Val Leu Gln Leu Ser Asp Ala Leu Arg Asp Asp Ile Leu Pro Glu
    450                 455                 460                 
Leu Gly Val Arg
465             


<210> 86
<211> 321
<212> PRT
<213> Mus musculus

<400> 86
Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Gly Gly Ser Glu Val Thr
 1               5                  10                  15      
Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Glu Glu Phe
            20                  25                  30          
His Lys Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr
        35                  40                  45              
Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile
    50                  55                  60                  
Val Asp Asn Gly Tyr Gly Tyr Ala Ser Asn Gly Ser Val Tyr Phe Asp
65                  70                  75                  80  
Thr Ala Lys Phe Ala Ala Ser Glu Lys His Ser Tyr Gly Lys Leu Val
                85                  90                  95      
Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp
            100                 105                 110         
Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp
        115                 120                 125             
Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys
    130                 135                 140                 
Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met
145                 150                 155                 160 
Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe
                165                 170                 175     
Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala
            180                 185                 190         
Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His
        195                 200                 205             
Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile
    210                 215                 220                 
Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu
225                 230                 235                 240 
Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn
                245                 250                 255     
Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Met Asn Glu Phe Phe
            260                 265                 270         
Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln
        275                 280                 285             
Phe Glu Lys Trp Glu Ala Glu Glu Val Glu Leu Asn Lys Asn Phe Tyr
    290                 295                 300                 
Gly Lys Lys Thr Ala Val His Glu Ala Leu Cys Asp Asn Ile Asp Thr
305                 310                 315                 320 
Arg
    


<210> 87
<211> 136
<212> PRT
<213> Homo sapiens

<400> 87
Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro
 1               5                  10                  15      
Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe
            20                  25                  30          
Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr
        35                  40                  45              
Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe
    50                  55                  60                  
Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe
65                  70                  75                  80  
Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala
                85                  90                  95      
Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala
            100                 105                 110         
Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val
        115                 120                 125             
Lys Leu Asn Glu Thr Thr Asp Pro
    130                 135     


<210> 88
<211> 408
<212> DNA
<213> Homo sapiens

<400> 88
ggccggcgtg tgcagcccca gtggtcccct cctgctggga cccagccatg cagactccac 60
ctttacaaca gcctcaccag gaacaaggaa gtgttcatac ctcaagatgg gaaaaaggtg 120
acgtggtatt gctgtgggcc aaccgtctat gacgcatctc acatggggca cgccaggtcc 180
tacatctctt ttgatatctt gagaagagtg ttgaaggatt acttcaaatt tgatgtcttt 240
tattgcatga acattacgga tattgatgac aagatcatca agagggcccg gcagaaccac 300
ctgttcgagc agtatcggga gaagaggcct gaagcggcac agctcttgga ggatgttcag 360
gccgccctga agccattttc agtaaaatta aatgagacca cggatccc              408

<210> 89
<211> 351
<212> PRT
<213> Homo sapiens

<400> 89
Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro
 1               5                  10                  15      
Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe
            20                  25                  30          
Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr
        35                  40                  45              
Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe
    50                  55                  60                  
Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe
65                  70                  75                  80  
Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala
                85                  90                  95      
Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala
            100                 105                 110         
Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val
        115                 120                 125             
Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg
    130                 135                 140                 
Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val
145                 150                 155                 160 
Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu
                165                 170                 175     
Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu
            180                 185                 190         
Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe
        195                 200                 205             
Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro
    210                 215                 220                 
Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn
225                 230                 235                 240 
Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly
                245                 250                 255     
Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser
            260                 265                 270         
Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln
        275                 280                 285             
Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys
    290                 295                 300                 
Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu
305                 310                 315                 320 
Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile
                325                 330                 335     
Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp
            340                 345                 350     


<210> 90
<211> 1053
<212> DNA
<213> Homo sapiens

<400> 90
ggccggcgtg tgcagcccca gtggtcccct cctgctggga cccagccatg cagactccac 60
ctttacaaca gcctcaccag gaacaaggaa gtgttcatac ctcaagatgg gaaaaaggtg 120
acgtggtatt gctgtgggcc aaccgtctat gacgcatctc acatggggca cgccaggtcc 180
tacatctctt ttgatatctt gagaagagtg ttgaaggatt acttcaaatt tgatgtcttt 240
tattgcatga acattacgga tattgatgac aagatcatca agagggcccg gcagaaccac 300
ctgttcgagc agtatcggga gaagaggcct gaagcggcac agctcttgga ggatgttcag 360
gccgccctga agccattttc agtaaaatta aatgagacca cggatcccga taaaaagcag 420
atgctcgaac ggattcagca cgcagtgcag cttgccacag agccacttga gaaagctgtg 480
cagtccagac tcacgggaga ggaagtcaac agctgtgtgg aggtgttgct ggaagaagcc 540
aaggatttgc tctctgactg gctggattct acacttggct gtgatgtcac tgacaattcc 600
atcttctcca agctgcccaa gttctgggag ggggacttcc acagagacat ggaagctctg 660
aatgttctcc ctccagatgt cttaacccgg gttagtgagt atgtgccaga aattgtgaac 720
tttgtccaga agattgtgga caacggttac ggctatgtct ccaatgggtc tgtctacttt 780
gatacagcga agtttgcttc tagcgagaag cactcctatg ggaagctggt gcctgaggcc 840
gttggagatc agaaagccct tcaagaaggg gaaggtgacc tgagcatctc tgcagaccgc 900
ctgagtgaga agcgctctcc caacgacttt gccttatgga aggcctctaa gcccggagaa 960
ccgtcctggc cgtgcccttg gggaaagggt cgtccgggct ggcatatcga gtgctcggcc 1020
atggcaggca ccctcctagg ggcttcgatg gac                              1053

<210> 91
<211> 128
<212> PRT
<213> Homo sapiens

<400> 91
Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg Phe
 1               5                  10                  15      
Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu Asn
            20                  25                  30          
Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile Ala
        35                  40                  45              
Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys Asp
    50                  55                  60                  
Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu Met
65                  70                  75                  80  
His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu Ser
                85                  90                  95      
Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val Lys
            100                 105                 110         
Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp
        115                 120                 125             


<210> 92
<211> 384
<212> DNA
<213> Homo sapiens

<400> 92
ctaggggctt cgatggacat tcacggaggt gggttcgacc tccggttccc ccaccatgac 60
aatgagctgg cacagtcgga ggcctacttt gaaaacgact gctgggtcag gtacttcctg 120
cacacaggcc acctgaccat tgcaggctgc aaaatgtcaa agtcactaaa aaacttcatc 180
accattaaag atgccttgaa aaagcactca gcacggcagt tgcggctggc cttcctcatg 240
cactcgtgga aggacaccct ggactactcc agcaacacca tggagtcagc gcttcaatat 300
gagaagttct tgaatgagtt tttcttaaat gtgaaagata tccttcgcgc tcctgttgac 360
atcactggtc agtttgagaa gtgg                                        384

<210> 93
<211> 154
<212> PRT
<213> Homo sapiens

<400> 93
Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu
 1               5                  10                  15      
Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys
            20                  25                  30          
Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg
        35                  40                  45              
Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val
    50                  55                  60                  
Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu
65                  70                  75                  80  
Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu
                85                  90                  95      
Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr
            100                 105                 110         
Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg
        115                 120                 125             
Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp
    130                 135                 140                 
Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu
145                 150                 


<210> 94
<211> 462
<212> DNA
<213> Homo sapiens

<400> 94
gctcctgttg acatcactgg tcagtttgag aagtggggag aagaagaagc agaactgaat 60
aagaactttt atgacaagaa gacagcaatt cacaaagccc tctgtgacaa tgttgacacc 120
cgcaccgtca tggaagagat gcgggccttg gtcagtcagt gcaacctcta tatggcagcc 180
cggaaagccg tgaggaagag gcccaaccag gctctgctgg agaacatcgc cctgtacctc 240
acccatatgc tgaagatctt tggggccgta gaagaggaca gctccctggg attcccggtc 300
ggagggcctg gaaccagcct cagtctcgag gccacagtca tgccctacct tcaggtgtta 360
tcagaattcc gagaaggagt gcggaagatt gcccgagagc aaaaagtccc tgagattctg 420
cagctcagcg atgccctgcg ggacaacatc ctgcccgagc tt                    462

<210> 95
<211> 194
<212> PRT
<213> Homo sapiens

<400> 95
Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu
 1               5                  10                  15      
Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys
            20                  25                  30          
Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg
        35                  40                  45              
Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val
    50                  55                  60                  
Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu
65                  70                  75                  80  
Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu
                85                  90                  95      
Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr
            100                 105                 110         
Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg
        115                 120                 125             
Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp
    130                 135                 140                 
Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp
145                 150                 155                 160 
His Glu Gly Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu
                165                 170                 175     
Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys
            180                 185                 190         
Lys Lys
        


<210> 96
<211> 582
<212> DNA
<213> Homo sapiens

<400> 96
gctcctgttg acatcactgg tcagtttgag aagtggggag aagaagaagc agaactgaat 60
aagaactttt atgacaagaa gacagcaatt cacaaagccc tctgtgacaa tgttgacacc 120
cgcaccgtca tggaagagat gcgggccttg gtcagtcagt gcaacctcta tatggcagcc 180
cggaaagccg tgaggaagag gcccaaccag gctctgctgg agaacatcgc cctgtacctc 240
acccatatgc tgaagatctt tggggccgta gaagaggaca gctccctggg attcccggtc 300
ggagggcctg gaaccagcct cagtctcgag gccacagtca tgccctacct tcaggtgtta 360
tcagaattcc gagaaggagt gcggaagatt gcccgagagc aaaaagtccc tgagattctg 420
cagctcagcg atgccctgcg ggacaacatc ctgcccgagc ttggggtgcg gtttgaagac 480
cacgaaggac tgcccacagt ggtgaaactg gtagacagaa acaccttatt aaaagagaga 540
gaagaaaaga gacgggttga agaggagaag aggaagaaga aa                    582

<210> 97
<211> 509
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 97
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Lys Lys Gln Met Leu Glu Arg Ile Gln
            20                  25                  30          
His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser
        35                  40                  45              
Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu
    50                  55                  60                  
Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys
65                  70                  75                  80  
Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu
                85                  90                  95      
Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp
            100                 105                 110         
Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val
        115                 120                 125             
Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val
    130                 135                 140                 
Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly
145                 150                 155                 160 
Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly
                165                 170                 175     
Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser
            180                 185                 190         
Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser
        195                 200                 205             
Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys
    210                 215                 220                 
Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly
225                 230                 235                 240 
Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln
                245                 250                 255     
Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His
            260                 265                 270         
Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys
        275                 280                 285             
Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln
    290                 295                 300                 
Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr
305                 310                 315                 320 
Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn
                325                 330                 335     
Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile
            340                 345                 350         
Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys
        355                 360                 365             
Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn
    370                 375                 380                 
Val Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln
385                 390                 395                 400 
Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn
                405                 410                 415     
Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys
            420                 425                 430         
Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly
        435                 440                 445             
Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu
    450                 455                 460                 
Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu
465                 470                 475                 480 
Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn
                485                 490                 495     
Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp Leu Glu
            500                 505                 


<210> 98
<211> 509
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 98
Met Gly Ser Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln
 1               5                  10                  15      
Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly
            20                  25                  30          
Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp
        35                  40                  45              
Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp
    50                  55                  60                  
Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His
65                  70                  75                  80  
Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg
                85                  90                  95      
Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val
            100                 105                 110         
Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr
        115                 120                 125             
Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro
    130                 135                 140                 
Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu
145                 150                 155                 160 
Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe
                165                 170                 175     
Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro
            180                 185                 190         
Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala
        195                 200                 205             
Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp
    210                 215                 220                 
Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr
225                 230                 235                 240 
Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu
                245                 250                 255     
Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr
            260                 265                 270         
Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala
        275                 280                 285             
Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr
    290                 295                 300                 
Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu
305                 310                 315                 320 
Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe
                325                 330                 335     
Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp
            340                 345                 350         
Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg
        355                 360                 365             
Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr
    370                 375                 380                 
Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu
385                 390                 395                 400 
Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala
                405                 410                 415     
Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr
            420                 425                 430         
Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser
        435                 440                 445             
Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro
    450                 455                 460                 
Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu
465                 470                 475                 480 
Leu Gly Val Arg Phe Glu Asp Leu Glu Gly Lys Pro Ile Pro Asn Pro
                485                 490                 495     
Leu Leu Gly Leu Asp Ser Thr His His His His His His
            500                 505                 


<210> 99
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 99
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro
            20                  25                  30          
Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg
        35                  40                  45              
Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr
    50                  55                  60                  
Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg
65                  70                  75                  80  
Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe
                85                  90                  95      
Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys
            100                 105                 110         
Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu
        115                 120                 125             
Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu
    130                 135                 140                 
Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr Asp Pro
145                 150                 155         


<210> 100
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 100
Met Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln
 1               5                  10                  15      
Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val
            20                  25                  30          
Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro
        35                  40                  45              
Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser
    50                  55                  60                  
Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val
65                  70                  75                  80  
Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg
                85                  90                  95      
Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu
            100                 105                 110         
Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser
        115                 120                 125             
Val Lys Leu Asn Glu Thr Thr Asp Pro Gly Lys Pro Ile Pro Asn Pro
    130                 135                 140                 
Leu Leu Gly Leu Asp Ser Thr His His His His His His
145                 150                 155         


<210> 101
<211> 376
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 101
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Gly Arg Arg Val Gln Pro Gln Trp Ser
            20                  25                  30          
Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr Asn Ser Leu
        35                  40                  45              
Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys Lys Val Thr
    50                  55                  60                  
Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His Met Gly His
65                  70                  75                  80  
Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val Leu Lys Asp
                85                  90                  95      
Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp
            100                 105                 110         
Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe Glu Gln Tyr
        115                 120                 125             
Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp Val Gln Ala
    130                 135                 140                 
Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr Asp Pro Asp
145                 150                 155                 160 
Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln Leu Ala Thr
                165                 170                 175     
Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly Glu Glu Val
            180                 185                 190         
Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser
        195                 200                 205             
Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp Asn Ser Ile
    210                 215                 220                 
Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His Arg Asp Met
225                 230                 235                 240 
Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg Val Ser Glu
                245                 250                 255     
Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val Asp Asn Gly
            260                 265                 270         
Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe
        275                 280                 285             
Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro Glu Ala Val
    290                 295                 300                 
Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser
305                 310                 315                 320 
Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp
                325                 330                 335     
Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys
            340                 345                 350         
Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu
        355                 360                 365             
Leu Gly Ala Ser Met Asp Leu Glu
    370                 375     


<210> 102
<211> 376
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 102
Met Gly Ser Gly Arg Arg Val Gln Pro Gln Trp Ser Pro Pro Ala Gly
 1               5                  10                  15      
Thr Gln Pro Cys Arg Leu His Leu Tyr Asn Ser Leu Thr Arg Asn Lys
            20                  25                  30          
Glu Val Phe Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys
        35                  40                  45              
Gly Pro Thr Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr
    50                  55                  60                  
Ile Ser Phe Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe
65                  70                  75                  80  
Asp Val Phe Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile
                85                  90                  95      
Lys Arg Ala Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg
            100                 105                 110         
Pro Glu Ala Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro
        115                 120                 125             
Phe Ser Val Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met
    130                 135                 140                 
Leu Glu Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu
145                 150                 155                 160 
Lys Ala Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val
                165                 170                 175     
Glu Val Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp
            180                 185                 190         
Ser Thr Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu
        195                 200                 205             
Pro Lys Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn
    210                 215                 220                 
Val Leu Pro Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu
225                 230                 235                 240 
Ile Val Asn Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val
                245                 250                 255     
Ser Asn Gly Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu
            260                 265                 270         
Lys His Ser Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys
        275                 280                 285             
Ala Leu Gln Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu
    290                 295                 300                 
Ser Glu Lys Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys
305                 310                 315                 320 
Pro Gly Glu Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly
                325                 330                 335     
Trp His Ile Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser
            340                 345                 350         
Met Asp Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
        355                 360                 365             
Ser Thr His His His His His His
    370                 375     


<210> 103
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 103
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly
            20                  25                  30          
Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu
        35                  40                  45              
Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly
    50                  55                  60                  
His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe
65                  70                  75                  80  
Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg
                85                  90                  95      
Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser
            100                 105                 110         
Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe
        115                 120                 125             
Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly
    130                 135                 140                 
Gln Phe Glu Lys Trp
145                 


<210> 104
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 104
Met Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp Leu Arg
 1               5                  10                  15      
Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr Phe Glu
            20                  25                  30          
Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu Thr Ile
        35                  40                  45              
Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr Ile Lys
    50                  55                  60                  
Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala Phe Leu
65                  70                  75                  80  
Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr Met Glu
                85                  90                  95      
Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu Asn Val
            100                 105                 110         
Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys
        115                 120                 125             
Trp Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
    130                 135                 140                 
His His His His His
145                 


<210> 105
<211> 175
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 105
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys
            20                  25                  30          
Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys
        35                  40                  45              
Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val
    50                  55                  60                  
Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala
65                  70                  75                  80  
Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn
                85                  90                  95      
Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu
            100                 105                 110         
Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu
        115                 120                 125             
Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe
    130                 135                 140                 
Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile
145                 150                 155                 160 
Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu
                165                 170                 175 


<210> 106
<211> 175
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 106
Met Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu
 1               5                  10                  15      
Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His
            20                  25                  30          
Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met
        35                  40                  45              
Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala
    50                  55                  60                  
Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr
65                  70                  75                  80  
Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser
                85                  90                  95      
Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala
            100                 105                 110         
Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val
        115                 120                 125             
Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser
    130                 135                 140                 
Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Lys Pro Ile Pro
145                 150                 155                 160 
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                165                 170                 175 


<210> 107
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 107
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Pro Val Asp Ile Thr Gly Gln Phe
            20                  25                  30          
Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp
        35                  40                  45              
Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg
    50                  55                  60                  
Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr
65                  70                  75                  80  
Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu
                85                  90                  95      
Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala
            100                 105                 110         
Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr
        115                 120                 125             
Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser
    130                 135                 140                 
Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro
145                 150                 155                 160 
Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu
                165                 170                 175     
Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys
            180                 185                 190         
Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg
        195                 200                 205             
Val Glu Glu Glu Lys Arg Lys Lys Lys Leu Glu
    210                 215                 


<210> 108
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cysteinyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 108
Met Gly Ser Ala Pro Val Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly
 1               5                  10                  15      
Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala
            20                  25                  30          
Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg Thr Val Met Glu
        35                  40                  45              
Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg
    50                  55                  60                  
Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala
65                  70                  75                  80  
Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala Val Glu Glu Asp
                85                  90                  95      
Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr Ser Leu Ser Leu
            100                 105                 110         
Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu
        115                 120                 125             
Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro Glu Ile Leu Gln
    130                 135                 140                 
Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu Leu Gly Val Arg
145                 150                 155                 160 
Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys Leu Val Asp Arg
                165                 170                 175     
Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg Val Glu Glu Glu
            180                 185                 190         
Lys Arg Lys Lys Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu
        195                 200                 205             
Gly Leu Asp Ser Thr His His His His His His
    210                 215                 


<210> 109
<211> 1464
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Cysteinyl tRNA Synthetase
      polynucleotide

<400> 109
ggatccaaaa aacaaatgct ggagcgtatc caacacgccg ttcagctggc aacagaacca 60
ctggaaaaag ccgtacagtc tcgtctgaca ggcgaagaag tgaattcctg tgtcgaggtg 120
ctgctggagg aggcaaaaga tctgctgtct gattggctgg attctaccct gggttgtgat 180
gttaccgata acagcatctt ctccaaactg ccgaaatttt gggagggcga ctttcaccgt 240
gatatggaag ctctgaatgt gctgccaccg gatgtgctga cacgtgtgag cgaatatgtt 300
ccggaaatcg tgaacttcgt ccagaaaatc gtcgataacg ggtatggcta tgtgagtaac 360
ggttccgtgt attttgatac cgccaaattc gccagtagtg agaaacactc ctatgggaaa 420
ctggtgcctg aagccgttgg tgaccagaaa gctctgcaag aaggtgaggg cgatctgtct 480
attagtgccg atcgtctgag cgaaaaacgt tccccgaacg actttgctct gtggaaagcg 540
tctaaacctg gtgagccttc atggccttgt ccttggggta aagggcgtcc tggttggcat 600
attgaatgct ccgctatggc aggaacactg ctgggagcaa gcatggatat tcacggaggt 660
ggctttgatc tgcgttttcc tcatcacgac aacgaactgg cacaaagcga agcctatttc 720
gagaacgatt gttgggttcg ttatttcctg catacgggcc acctgacaat tgctggctgt 780
aaaatgtcca aatccctgaa aaacttcatt accattaaag atgccctgaa aaaacattct 840
gcccgtcagc tgcgtctggc atttctgatg cattcttgga aagacaccct ggactatagc 900
agtaacacca tggaatcagc cctgcagtat gaaaaattcc tgaatgagtt cttcctgaat 960
gtgaaagaca ttctgcgtgc accggttgat attacgggtc aatttgaaaa atggggcgag 1020
gaggaggccg aactgaataa aaacttttat gacaaaaaaa ccgccatcca taaagcactg 1080
tgtgacaacg tcgatactcg taccgtcatg gaagagatgc gtgccctggt gagtcagtgt 1140
aacctgtata tggccgctcg taaagcggtc cgtaaacgtc ctaaccaagc gctgctggaa 1200
aacattgccc tgtatctgac ccacatgctg aaaatctttg gtgccgtgga agaggattct 1260
tctctggggt ttcctgttgg tggtccgggt acaagtctgt cactggaggc tacagtgatg 1320
ccttatctgc aagttctgag tgagtttcgt gaaggtgtcc gtaaaattgc tcgtgagcag 1380
aaagttcctg agattctgca gctgtctgac gcactgcgtg ataacatcct gcctgaactg 1440
ggagtccgtt ttgaggatct cgag                                        1464

<210> 110
<211> 420
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Cysteinyl tRNA Synthetase
      polynucleotide

<400> 110
ggtcgtcgcg tacagccaca atggagcccg ccagcaggca cccagccgtg tcgtctgcac 60
ctgtacaaca gcctgactcg caacaaagag gtgtttatcc cgcaagacgg taaaaaggtc 120
acgtggtatt gctgcggtcc gaccgtttat gacgcgtccc acatgggcca tgcgcgctct 180
tatatcagct ttgatattct gcgccgtgtt ttgaaggatt acttcaagtt cgacgtgttc 240
tactgtatga acatcaccga cattgatgat aagattatca aacgtgcacg tcagaatcat 300
ttgtttgagc aataccgtga aaagcgtccg gaagcggcgc aactgctgga ggatgtccag 360
gctgccctga aaccgttcag cgttaaactg aatgaaacga ccgacccgta atgactcgag 420


<210> 111
<211> 1065
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Cysteinyl tRNA Synthetase
      polynucleotide

<400> 111
ggatccggac gtcgtgttca gcctcaatgg agtcctccgg ctggtactca accatgtcgt 60
ctgcacctgt ataatagcct gactcgtaat aaagaggtgt tcatcccaca agatggcaaa 120
aaagtgacct ggtattgctg tggtcctacg gtgtatgatg ccagccacat gggtcatgct 180
cgttcctata tctcgtttga tattctgcgc cgtgtgctga aagactattt caaattcgac 240
gtgttctatt gtatgaacat taccgacatc gatgataaaa tcattaaacg tgcccgccag 300
aaccacctgt ttgagcagta tcgtgaaaaa cgcccggaag cagctcaact gctggaagat 360
gtccaagcag ctctgaaacc ttttagcgtg aaactgaatg aaaccaccga tccggataaa 420
aaacaaatgc tggagcgtat tcaacacgct gttcagctgg ctacagaacc gctggaaaaa 480
gcggtccaat ctcgtctgac tggtgaagag gtcaactcct gtgtcgaagt cctgctggaa 540
gaggctaaag acctgctgtc tgactggctg gacagtacac tgggatgtga cgtgacggac 600
aattccatct tttcgaaact gccgaaattc tgggaaggtg atttccaccg tgacatggag 660
gcactgaacg tcctgccgcc agatgttctg actcgtgtgt ccgagtatgt gcctgagatc 720
gtcaactttg ttcaaaaaat tgtggacaac ggttatggct atgtctcaaa tggctcggtg 780
tattttgata cggccaaatt tgcttcgagc gagaaacatt cttatggcaa actggtccct 840
gaggcagtag gcgaccaaaa agctctgcaa gagggcgagg gggatctgtc gattagcgcc 900
gaccgtctga gcgagaaacg ctctcctaat gacttcgccc tgtggaaagc aagcaaaccg 960
ggtgaaccga gttggccttg cccatggggt aaaggccgcc caggatggca catcgagtgt 1020
agtgctatgg ccggtactct gctgggtgct agtatggacc tcgag                 1065

<210> 112
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Cysteinyl tRNA Synthetase
      polynucleotide

<400> 112
ctgggcgcat cgatggacat tcacggcggc ggcttcgatt tgcgttttcc gcaccatgat 60
aatgagctgg cccaatctga ggcgtatttt gagaatgact gctgggttcg ttactttctg 120
cataccggtc acttgaccat cgcgggttgt aagatgagca agagcctgaa gaactttatc 180
acgattaaag acgctctgaa gaaacactcc gcgcgtcaac tgcgcttggc gttcctgatg 240
catagctgga aagacaccct ggactacagc agcaatacga tggaaagcgc cctgcagtat 300
gagaaatttc tgaacgaatt cttcctgaac gtgaaggata tcctgcgcgc accggtcgat 360
attactggtc agttcgaaaa atggtaatga ctcgag                           396

<210> 113
<211> 474
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Cysteinyl tRNA Synthetase
      polynucleotide

<400> 113
gcaccagtag acatcaccgg tcaattcgaa aaatggggcg aggaagaggc agagctgaat 60
aagaactttt acgacaagaa aaccgccatc cataaagcgc tgtgcgataa tgttgatact 120
cgtaccgtta tggaagagat gcgcgcactg gtcagccaat gtaatctgta tatggcggct 180
cgtaaggctg ttcgtaaacg tccgaaccag gccctgctgg agaacatcgc gctgtatctg 240
acccacatgt tgaagatttt tggtgcggtc gaagaagata gcagcctggg cttcccggtg 300
ggcggtccgg gtacgagcct gagcctggaa gcgacggtta tgccgtacct gcaggtgttg 360
tccgagttcc gtgaaggtgt ccgcaagatt gcccgcgagc agaaagtgcc ggagatcctg 420
caattgtctg acgcgctgcg tgacaacatt ctgccggagc tgtaatgact cgag       474

<210> 114
<211> 594
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Cysteinyl tRNA Synthetase
      polynucleotide

<400> 114
ggatccgccc ctgtcgatat tacagggcag ttcgaaaaat ggggtgaaga ggaagcagaa 60
ctgaacaaaa acttctatga caaaaaaacc gccatccata aagcactgtg tgacaacgtc 120
gatacccgta ccgttatgga ggaaatgcgc gcactggttt cacagtgtaa cctgtatatg 180
gcagcccgta aagctgtccg taaacgccca aatcaagccc tgctggagaa tattgctctg 240
tatctgactc acatgctgaa aatctttggc gccgttgaag aggattctag cctgggtttt 300
ccggtaggag gtccgggaac aagtctgagt ctggaagcaa ccgtaatgcc gtatctgcag 360
gtcctgagcg aatttcgtga aggcgtccgt aaaattgccc gtgagcagaa agttcctgag 420
atcctgcaac tgtctgacgc actgcgtgat aacatcctgc ctgaactggg tgttcgcttt 480
gaggaccatg aaggtctgcc aacagtggtc aaactggtgg atcgtaatac tctgctgaaa 540
gaacgtgaag agaaacgtcg tgttgaggag gagaaacgta aaaaaaaact cgag       594
