                               SEQUENCE LISTING

<110> BIOGEN IDEC MA INC.

<120> LIGHT TARGETING MOLECULES AND USES THEREOF

<130> B2047-7070WO

<140> 
<141>

<150> 61/328,085
<151> 2010-04-26

<150> 61/444,937
<151> 2011-02-21

<160> 199  

<170> PatentIn version 3.5

<210> 1
<211> 240
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210> 2
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro 
225                 230                 235                 240 


Ala Gly Ser Trp Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                245                 250                 255     


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            260                 265                 270         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        275                 280                 285             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    290                 295                 300                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
305                 310                 315                 320 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                325                 330                 335     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            340                 345                 350         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        355                 360                 365             


Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu 
    370                 375                 380                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
385                 390                 395                 400 


<210> 3
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide

<400> 3
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Leu His Trp Arg Leu Gly Glu Met Val Thr Arg 
225                 230                 235                 240 


Leu Pro Asp Gly Pro Ala Gly Ser Trp Gln Glu Arg Arg Ser His Glu 
                245                 250                 255     


Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly 
            260                 265                 270         


Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu 
        275                 280                 285             


Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly 
    290                 295                 300                 


Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro 
305                 310                 315                 320 


Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro 
                325                 330                 335     


Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys 
            340                 345                 350         


Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu 
        355                 360                 365             


Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val 
    370                 375                 380                 


Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe 
385                 390                 395                 400 


Gly Ala Phe Met Val 
                405 


<210> 4
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide

<400> 4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
                245                 250                 255     


Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
            260                 265                 270         


Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
        275                 280                 285             


Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
    290                 295                 300                 


Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
305                 310                 315                 320 


Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
                325                 330                 335     


Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
            340                 345                 350         


Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
        355                 360                 365             


Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
    370                 375                 380                 


Ser Tyr Phe Gly Ala Phe Met Val 
385                 390         


<210> 5
<211> 723
<212> DNA
<213> Homo sapiens

<400> 5
atggaggaga gtgtcgtacg gccctcagtg tttgtggtgg atggacagac cgacatccca     60

ttcacgaggc tgggacgaag ccaccggaga cagtcgtgca gtgtggcccg ggtgggtctg    120

ggtctcttgc tgttgctgat gggggccggg ctggccgtcc aaggctggtt cctcctgcag    180

ctgcactggc gtctaggaga gatggtcacc cgcctgcctg acggacctgc aggctcctgg    240

gagcagctga tacaagagcg aaggtctcac gaggtcaacc cagcagcgca tctcacaggg    300

gccaactcca gcttgaccgg cagcgggggg ccgctgttat gggagactca gctgggcctg    360

gccttcctga ggggcctcag ctaccacgat ggggcccttg tggtcaccaa agctggctac    420

tactacatct actccaaggt gcagctgggc ggtgtgggct gcccgctggg cctggccagc    480

accatcaccc acggcctcta caagcgcaca ccccgctacc ccgaggagct ggagctgttg    540

gtcagccagc agtcaccctg cggacgggcc accagcagct cccgggtctg gtgggacagc    600

agcttcctgg gtggtgtggt acacctggag gctggggaga aggtggtcgt ccgtgtgctg    660

gatgaacgcc tggttcgact gcgtgatggt acccggtctt acttcggggc tttcatggtg    720

tga                                                                  723


<210> 6
<211> 1203
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide

<400> 6
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc    300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa    660

tcttgtgaca aactgcactg gcgtctagga gagatggtca cccgcctgcc tgacggacct    720

gcaggctcct ggcaagagcg aaggtctcac gaggtcaacc cagcagcgca tctcacaggg    780

gccaactcca gcttgaccgg cagcgggggg ccgctgttat gggagactca gctgggcctg    840

gccttcctga ggggcctcag ctaccacgat ggggcccttg tggtcaccaa agctggctac    900

tactacatct actccaaggt gcagctgggc ggtgtgggct gcccgctggg cctggccagc    960

accatcaccc acggcctcta caagcgcaca ccccgctacc ccgaggagct ggagctgttg   1020

gtcagccagc agtcaccctg cggacgggcc accagcagct cccgggtctg gtgggacagc   1080

agcttcctgg gtggtgtggt acacctggag gctggggagg aggtggtcgt ccgtgtgctg   1140

gatgaacgcc tggttcgact gcgtgatggt acccggtctt acttcggggc tttcatggtg   1200

tga                                                                 1203


<210> 7
<211> 1218
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 7
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc    300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa    660

tcttgtgaca aaggcggtgg agggtccctg cactggcgtc taggagagat ggtcacccgc    720

ctgcctgacg gacctgcagg ctcctggcaa gagcgaaggt ctcacgaggt caacccagca    780

gcgcatctca caggggccaa ctccagcttg accggcagcg gggggccgct gttatgggag    840

actcagctgg gcctggcctt cctgaggggc ctcagctacc acgatggggc ccttgtggtc    900

accaaagctg gctactacta catctactcc aaggtgcagc tgggcggtgt gggctgcccg    960

ctgggcctgg ccagcaccat cacccacggc ctctacaagc gcacaccccg ctaccccgag   1020

gagctggagc tgttggtcag ccagcagtca ccctgcggac gggccaccag cagctcccgg   1080

gtctggtggg acagcagctt cctgggtggt gtggtacacc tggaggctgg ggaggaggtg   1140

gtcgtccgtg tgctggatga acgcctggtt cgactgcgtg atggtacccg gtcttacttc   1200

ggggctttca tggtgtga                                                 1218


<210> 8
<211> 1179
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 8
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc    300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa    660

tcttgtgaca aaggcggtgg agggtccggt gggggcggat ctgggggcgg cgggtccggt    720

ggtggtggta gtaacccagc agcgcatctc acaggggcca actccagctt gaccggcagc    780

ggggggccgc tgttatggga gactcagctg ggcctggcct tcctgagggg cctcagctac    840

cacgatgggg cccttgtggt caccaaagct ggctactact acatctactc caaggtgcag    900

ctgggcggtg tgggctgccc gctgggcctg gccagcacca tcacccacgg cctctacaag    960

cgcacacccc gctaccccga ggagctggag ctgttggtca gccagcagtc accctgcgga   1020

cgggccacca gcagctcccg ggtctggtgg gacagcagct tcctgggtgg tgtggtacac   1080

ctggaggctg gggaggaggt ggtcgtccgt gtgctggatg aacgcctggt tcgactgcgt   1140

gatggtaccc ggtcttactt cggggctttc atggtgtga                          1179


<210> 9
<211> 4
<212> PRT
<213> Homo sapiens

<400> 9
Glu Gln Leu Ile 
1               


<210> 10
<211> 4
<212> PRT
<213> Mus sp.

<400> 10
Glu Lys Leu Ile 
1               


<210> 11
<211> 119
<212> PRT
<213> Homo sapiens 

<400> 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 12
<211> 357
<212> DNA
<213> Homo sapiens 

<400> 12
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tcttacggta tggtttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctcttctt ctggtggcct tacttggtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagccctccg    300

ggtatagcag tggcccggga ctactggggc cagggcaccc tggtcaccgt ctcaagc       357


<210> 13
<211> 107
<212> PRT
<213> Homo sapiens 

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Leu Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 14
<211> 321
<212> DNA
<213> Homo sapiens 

<400> 14
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct    180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccctcctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210> 15
<211> 125
<212> PRT
<213> Homo sapiens 

<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Asn Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Arg Ser Ser Gly Gly Tyr Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asn Ser Gly Tyr Ser Tyr Trp Asp Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 16
<211> 375
<212> DNA
<213> Homo sapiens 

<400> 16
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cgttacaata tgtggtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atccgttctt ctggtggcta tactggttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtat attactgtgc gagatggaat    300

agtggataca gctactggga ctactactac ggtatggacg tctggggcca agggaccacg    360

gtcaccgtct caagc                                                     375


<210> 17
<211> 107
<212> PRT
<213> Homo sapiens 

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Thr Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 18
<211> 321
<212> DNA
<213> Homo sapiens 

<400> 18
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacaa tttaatactt acccgattac tttcggccct    300

gggaccaaag tggatatcaa a                                              321


<210> 19
<211> 116
<212> PRT
<213> Homo sapiens 

<400> 19
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Met Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Pro Ser Gly Gly Tyr Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Gly Thr Tyr Pro Leu Thr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 20
<211> 348
<212> DNA
<213> Homo sapiens 

<400> 20
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct ccttacatga tggtttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttgg atctctcctt ctggtggcta tactttttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc atatgggacc    300

tacccgctta catactgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210> 21
<211> 106
<212> PRT
<213> Homo sapiens 

<400> 21
Gln Ser Glu Leu Thr Gln Thr Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Ser Trp Phe Gln Leu Lys Pro Gly Gln Ser Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Trp Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Thr 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ser His Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210> 22
<211> 318
<212> DNA
<213> Homo sapiens 

<400> 22
cagagcgaat tgactcagac accctcagtg tccgtgtccc caggacagac agccagcatc     60

acctgttctg gagataaatt gggggataag tatgtttcct ggttccagct gaagccaggc    120

cagtcccctc ttttggtcat ctatcaagat agtaagtggc cctcagggat ccctgagcga    180

ttctctggct ccaattctgg gaacacagcc actctgacca tcagcgggac ccaggctacg    240

gatgaggctg actactattg tcaggtgtgg gacatcagcc atgtggtatt cggcggaggg    300

accaagctga ccgtccta                                                  318


<210> 23
<211> 130
<212> PRT
<213> Homo sapiens 

<400> 23
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Gly Ser Ser Gly Gly Met Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Pro Thr Gly Tyr Tyr Asp Ser Ser Gly Trp Val Tyr 
            100                 105                 110         


Ser Tyr Tyr Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 24
<211> 390
<212> DNA
<213> Homo sapiens 

<400> 24
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aattactata tgatgtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atcggttctt ctggtggcat gactaattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagaggctac    300

ccgacaggtt actatgatag tagtggctgg gtctactcct actacggtat cgacgtctgg    360

ggccaaggga ccacggtcac cgtctcaagc                                     390


<210> 25
<211> 107
<212> PRT
<213> Homo sapiens 

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Thr Asp Asn Arg 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Val Asn Leu Lys Arg Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asn Phe Ile Leu Thr Ile Thr Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Phe Cys Gln His Ser Asp Gly Leu Ser Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 26
<211> 321
<212> DNA
<213> Homo sapiens 

<400> 26
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc     60

atcacttgcc aggcgagtca ggacactgac aaccgtctac attggtatca gcagaagtca    120

ggtagagccc ctaaactcct catctacgat gcagtcaatt tgaaaagggg ggtcccttca    180

aggttccgtg gaagtggatc tgggacaaat tttattttga ccatcaccaa cctgcagcct    240

gaagatatgg caacatattt ctgtcaacat tctgatggtc tgtcactcgc tttcggcgga    300

gggaccaaac tggagatcaa a                                              321


<210> 27
<211> 123
<212> PRT
<213> Homo sapiens 

<400> 27
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Met Tyr 
            20                  25                  30          


Ser Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Gly Ser Ser Gly Gly Gln Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Leu Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 28
<211> 369
<212> DNA
<213> Homo sapiens 

<400> 28
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct atgtactcta tgcagtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atcggttctt ctggtggcca gactggttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagtacgc    300

gattactatg gttcggggag ttattatctc gacccctggg gccagggcac cctggtcacc    360

gtctcaagc                                                            369


<210> 29
<211> 107
<212> PRT
<213> Homo sapiens 

<400> 29
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 30
<211> 321
<212> DNA
<213> Homo sapiens 

<400> 30
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta cctcgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210> 31
<211> 117
<212> PRT
<213> Homo sapiens 

<400> 31
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Pro Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Tyr Ser Gly Thr Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 32
<211> 351
<212> DNA
<213> Homo sapiens 

<400> 32
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtactcta tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctcttctt ctggtggccc tactcattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagattca    300

tcgtatagtg ggacctcatg gggccaggga accctggtca ccgtctcaag c             351


<210> 33
<211> 110
<212> PRT
<213> Homo sapiens 

<400> 33
Gln Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Glu 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Thr Asp Tyr Tyr Cys Thr Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 34
<211> 330
<212> DNA
<213> Homo sapiens 

<400> 34
cagtacgaat tgactcagcc accctcagtg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagttc caacatcgga agtgagtatg tgtactggtt ccagcagctc    120

ccaggaacgg cccccagact cctcatctat aggaatgatc agcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg agactgatta ttactgtaca acatgggatg acagcctgag tggtccggtg    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210> 35
<211> 120
<212> PRT
<213> Homo sapiens 

<400> 35
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Trp Pro Ser Gly Gly Phe Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Ser Ser Ser Trp Tyr Gly Tyr Leu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 36
<211> 360
<212> DNA
<213> Homo sapiens 

<400> 36
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tattacccta tgatgtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctggcctt ctggtggctt tactaagtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccacgt attactgtgc gagagttagt    300

agcagcagct ggtacgggta tctctactgg ggccagggaa ccctggtcac cgtctcaagc    360


<210> 37
<211> 110
<212> PRT
<213> Homo sapiens 

<400> 37
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ala 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Ala Leu 
            100                 105                 110 


<210> 38
<211> 330
<212> DNA
<213> Homo sapiens 

<400> 38
cagagcgctt tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caacatcgga cgtaatactg taaactggta ccagcagctc    120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct    180

gaccgattcg ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tgcttgggtg    300

ttcggcggag ggaccaagct gaccgcccta                                     330


<210> 39
<211> 119
<212> PRT
<213> Homo sapiens 

<400> 39
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Ser Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Val Ser Ser Gly Gly Gln Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Lys Gly Tyr Tyr Tyr Tyr Ile Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 40
<211> 357
<212> DNA
<213> Homo sapiens 

<400> 40
gaagttcaat tgttagagtc tggtggcggt ctggttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtactcta tgtggtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcgtttctt ctggtggcca gactcgttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggctgtgt attactgtgc gagagttaag    300

ggttactact actacataga cgtctggggc aaagggacca cggtcaccgt ctcaagc       357


<210> 41
<211> 108
<212> PRT
<213> Homo sapiens 

<400> 41
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Gly Tyr Ser Ser 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 42
<211> 324
<212> DNA
<213> Homo sapiens 

<400> 42
gacatccaga tgacccagtc tccaggcacc ctgtctttgt ctccagggga gagagccacc     60

ctctcctgca gggccagtca gagtgttgac agcagctact tatcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggcatccca    180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccgtcag cagactggag    240

cctgaagatt ttgctgtgta ttattgtcag cagcatggtt actcatccag gacgttcggc    300

caagggacca aggtggaaat caaa                                           324


<210> 43
<211> 123
<212> PRT
<213> Homo sapiens 

<400> 43
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ser Ser Gly Gly Pro Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Lys Pro Asp Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 44
<211> 369
<212> DNA
<213> Homo sapiens

<400> 44
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtaccgta tgaattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctattctt ctggtggccc tactaattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctcagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acagccgtgt attactgtac gagagagaaa    300

ccagattact atgatagtag tggttatctt gactactggg gccagggcac cctggtcacc    360

gtctcaagc                                                            369


<210> 45
<211> 107
<212> PRT
<213> Homo sapiens 

<400> 45
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ser Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Gly Val Tyr Tyr Cys His Gln Tyr Gly Arg Pro Pro 
                85                  90                  95      


Val Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 46
<211> 321
<212> DNA
<213> Homo sapiens 

<400> 46
gacatccaga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagatccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttggagtgta ttactgtcac cagtatggta ggccaccggt tttcggcccc    300

gggaccaaag tggacatcaa a                                              321


<210> 47
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 47
Ser Tyr Gly Met Val 
1               5   


<210> 48
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 48
Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 49
<211> 10
<212> PRT
<213> Homo sapiens 

<400> 49
Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr 
1               5                   10  


<210> 50
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 50
Arg Tyr Asn Met Trp 
1               5   


<210> 51
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 51
Val Ile Arg Ser Ser Gly Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 52
<211> 16
<212> PRT
<213> Homo sapiens 

<400> 52
Trp Asn Ser Gly Tyr Ser Tyr Trp Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210> 53
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 53
Pro Tyr Met Met Val 
1               5   


<210> 54
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 54
Trp Ile Ser Pro Ser Gly Gly Tyr Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 55
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 55
Gly Thr Tyr Pro Leu Thr Tyr 
1               5           


<210> 56
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 56
Asn Tyr Tyr Met Met 
1               5   


<210> 57
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 57
Val Ile Gly Ser Ser Gly Gly Met Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 58
<211> 21
<212> PRT
<213> Homo sapiens 

<400> 58
Gly Tyr Pro Thr Gly Tyr Tyr Asp Ser Ser Gly Trp Val Tyr Ser Tyr 
1               5                   10                  15      


Tyr Gly Ile Asp Val 
            20      


<210> 59
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 59
Met Tyr Ser Met Gln 
1               5   


<210> 60
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 60
Val Ile Gly Ser Ser Gly Gly Gln Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 61
<211> 14
<212> PRT
<213> Homo sapiens 

<400> 61
Val Arg Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Leu Asp Pro 
1               5                   10                  


<210> 62
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 62
Trp Tyr Ser Met Ser 
1               5   


<210> 63
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 63
Ser Ile Ser Ser Ser Gly Gly Pro Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 64
<211> 8
<212> PRT
<213> Homo sapiens 

<400> 64
Asp Ser Ser Tyr Ser Gly Thr Ser 
1               5               


<210> 65
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 65
Tyr Tyr Pro Met Met 
1               5   


<210> 66
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 66
Ser Ile Trp Pro Ser Gly Gly Phe Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 67
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 67
Val Ser Ser Ser Ser Trp Tyr Gly Tyr Leu Tyr 
1               5                   10      


<210> 68
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 68
Trp Tyr Ser Met Trp 
1               5   


<210> 69
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 69
Ser Ile Val Ser Ser Gly Gly Gln Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 70
<211> 10
<212> PRT
<213> Homo sapiens 

<400> 70
Val Lys Gly Tyr Tyr Tyr Tyr Ile Asp Val 
1               5                   10  


<210> 71
<211> 5
<212> PRT
<213> Homo sapiens 

<400> 71
Trp Tyr Arg Met Asn 
1               5   


<210> 72
<211> 17
<212> PRT
<213> Homo sapiens 

<400> 72
Ser Ile Tyr Ser Ser Gly Gly Pro Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 73
<211> 14
<212> PRT
<213> Homo sapiens 

<400> 73
Glu Lys Pro Asp Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Tyr 
1               5                   10                  


<210> 74
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 74
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 75
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 75
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 76
<211> 9
<212> PRT
<213> Homo sapiens 

<400> 76
Gln Lys Tyr Asn Ser Ala Leu Leu Thr 
1               5                   


<210> 77
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 77
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 78
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 78
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 79
<211> 9
<212> PRT
<213> Homo sapiens 

<400> 79
Gln Gln Phe Asn Thr Tyr Pro Ile Thr 
1               5                   


<210> 80
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 80
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val Ser 
1               5                   10      


<210> 81
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 81
Gln Asp Ser Lys Trp Pro Ser 
1               5           


<210> 82
<211> 9
<212> PRT
<213> Homo sapiens 

<400> 82
Gln Val Trp Asp Ile Ser His Val Val 
1               5                   


<210> 83
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 83
Gln Ala Ser Gln Asp Thr Asp Asn Arg Leu His 
1               5                   10      


<210> 84
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 84
Asp Ala Val Asn Leu Lys Arg 
1               5           


<210> 85
<211> 9
<212> PRT
<213> Homo sapiens 

<400> 85
Gln His Ser Asp Gly Leu Ser Leu Ala 
1               5                   


<210> 86
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 86
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 87
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 87
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 88
<211> 9
<212> PRT
<213> Homo sapiens 

<400> 88
Gln Gln Ser Tyr Ser Thr Ser Trp Thr 
1               5                   


<210> 89
<211> 13
<212> PRT
<213> Homo sapiens 

<400> 89
Ser Gly Ser Ser Ser Asn Ile Gly Ser Glu Tyr Val Tyr 
1               5                   10              


<210> 90
<211> 7
<212> PRT
<213> Homo sapiens 
	
<400> 90
Arg Asn Asp Gln Arg Pro Ser 
1               5           


<210> 91
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 91
Thr Thr Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 92
<211> 13
<212> PRT
<213> Homo sapiens 

<400> 92
Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Thr Val Asn 
1               5                   10              


<210> 93
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 93
Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210> 94
<211> 11
<212> PRT
<213> Homo sapiens 

<400> 94
Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 
1               5                   10      


<210> 95
<211> 12
<212> PRT
<213> Homo sapiens 

<400> 95
Arg Ala Ser Gln Ser Val Asp Ser Ser Tyr Leu Ser 
1               5                   10          


<210> 96
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 96
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 97
<211> 9
<212> PRT
<213> Homo sapiens 

<400> 97
Gln Gln His Gly Tyr Ser Ser Arg Thr 
1               5                   


<210> 98
<211> 12
<212> PRT
<213> Homo sapiens 

<400> 98
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 99
<211> 7
<212> PRT
<213> Homo sapiens 

<400> 99
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 100
<211> 8
<212> PRT
<213> Homo sapiens 

<400> 100
His Gln Tyr Gly Arg Pro Pro Val 
1               5               


<210> 101
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide

<400> 101
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Pro Ala Ala 
225                 230                 235                 240 


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
                245                 250                 255     


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
            260                 265                 270         


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
        275                 280                 285             


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
    290                 295                 300                 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
305                 310                 315                 320 


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
                325                 330                 335     


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
            340                 345                 350         


Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu 
        355                 360                 365             


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
    370                 375                 380                 


Gly Gly His His His His His His His His His His 
385                 390                 395     


<210> 102
<211> 1191
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 102
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc     60

tcctgcgcag cctccgggtt caggttcacc ttcaataact actacatgga ctgggtccgc    120

caggctccag ggcaggggct ggagtgggtc tcacgtatta gtagtagtgg tgatcccaca    180

tggtacgcag actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca    240

ctgtttcttc aaatgaacag cctgagagct gaggacacgg ctgtctatta ctgtgcgagc    300

ttgactacag ggtctgactc ctggggccag ggagtcctgg tcaccgtctc ctcagctagc    360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca    420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac    480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc    540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc    600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct    660

tgtggcggtg gtgggtccgg cggtggtggg tccggcggtg gtgggtccaa cccagcagcg    720

catctcacag gggccaactc cagcttgacc ggcagcgggg ggccgctgtt atgggagact    780

cagctgggcc tggccttcct gaggggcctc agctaccacg atggggccct tgtggtcacc    840

aaagctggct actactacat ctactccaag gtgcagctgg gcggtgtggg ctgcccgctg    900

ggcctggcca gcaccatcac ccacggcctc tacaagcgca caccccgcta ccccgaggag    960

ctggagctgt tggtcagcca gcagtcaccc tgcggacggg ccaccagcag ctcccgggtc   1020

tggtgggaca gcagcttcct gggtggtgtg gtacacctgg aggctgggga ggaggtggtc   1080

gtccgtgtgc tggatgaacg cctggttcga ctgcgtgatg gtacccggtc ttacttcggg   1140

gctttcatgg tgggaggaca tcatcatcat caccaccatc accatcactg a            1191


<210> 103
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide

<400> 103
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Asp Asn 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 104
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 104
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagattttg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210> 105
<211> 653
<212> PRT
<213> Homo sapiens

<400> 105
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Arg Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser 
                645                 650             


<210> 106
<211> 653
<212> PRT
<213> Macaca mulatta

<400> 106
Met Glu Leu Ala Ala Trp Tyr Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Leu Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Val Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Arg Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Leu Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr Arg Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Thr Cys Gln 
    610                 615                 620                 


Ser Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser 
                645                 650             


<210> 107
<211> 116
<212> PRT
<213> Homo sapiens

<400> 107
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Asp Thr Ala Met Gly Val Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 108
<211> 348
<212> DNA
<213> Homo sapiens

<400> 108
gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacgggat    300

acagctatgg gggtctgggg ccagggaacc ctggtcactg tctcctca                 348


<210> 109
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide

<400> 109
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Leu Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 110
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide

<400> 110
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct    180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccctcctcac tttcggcgga    300

ggtaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca    360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                    645


<210> 111
<211> 204
<212> PRT
<213> Homo sapiens

<400> 111
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile 
        35                  40                  45              


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
    50                  55                  60                  


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
65                  70                  75                  80  


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
                85                  90                  95      


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
            100                 105                 110         


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
        115                 120                 125             


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
    130                 135                 140                 


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
145                 150                 155                 160 


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
                165                 170                 175     


Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
            180                 185                 190         


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
        195                 200                 


<210> 112
<211> 615
<212> DNA
<213> Homo sapiens

<400> 112
atggaggaga gtgtcgtacg gccctcagtg tttgtggtgg atggacagac cgacatccca     60

ttcacgaggc tgggacgaag ccaccggaga cagtcgtgca gtgtggcccg ggacggacct    120

gcaggctcct gggagcagct gatacaagag cgaaggtctc acgaggtcaa cccagcagcg    180

catctcacag gggccaactc cagcttgacc ggcagcgggg ggccgctgtt atgggagact    240

cagctgggcc tggccttcct gaggggcctc agctaccacg atggggccct tgtggtcacc    300

aaagctggct actactacat ctactccaag gtgcagctgg gcggtgtggg ctgcccgctg    360

ggcctggcca gcaccatcac ccacggcctc tacaagcgca caccccgcta ccccgaggag    420

ctggagctgt tggtcagcca gcagtcaccc tgcggacggg ccaccagcag ctcccgggtc    480

tggtgggaca gcagcttcct gggtggtgtg gtacacctgg aggctgggga ggaggtggtc    540

gtccgtgtgc tggatgaacg cctggttcga ctgcgtgatg gtacccggtc ttacttcggg    600

gctttcatgg tgtga                                                     615


<210> 113
<211> 239
<212> PRT
<213> Mus sp.

<400> 113
Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      


Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         


Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             


Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 


Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         


Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             


Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 


Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 


<210> 114
<211> 720
<212> DNA
<213> Mus sp.

<400> 114
atggagagtg tggtacagcc ttcagtgttt gtggtggatg gacagacgga catcccattc     60

aggcggctgg aacagaacca ccggagacgg cgctgtggca ctgtccaggt cagcctggcc    120

ctggtgctgc tgctaggtgc tgggctggcc actcagggct ggtttctcct gagactgcat    180

caacgtcttg gagacatagt agctcatctg ccagatggag gcaaaggctc ctgggagaag    240

ctgatacaag atcaacgatc tcaccaggcc aacccagcag cacatcttac aggagccaac    300

gccagcttga taggtattgg tggacctctg ttatgggaga cacgacttgg cctggccttc    360

ttgaggggct tgacgtatca tgatggggcc ctggtgacca tggagcccgg ttactactat    420

gtgtactcca aagtgcagct gagcggcgtg ggctgccccc aggggctggc caatggcctc    480

cccatcaccc atggactata caagcgcaca tcccgctacc cgaaggagtt agaactgctg    540

gtcagtcggc ggtcaccctg tggccgggcc aacagctccc gagtctggtg ggacagcagc    600

ttcctgggcg gcgtggtaca tctggaggct ggggaagagg tggtggtccg cgtgcctgga    660

aaccgcctgg tcagaccacg tgacggcacc aggtcctatt tcggagcttt catggtctga    720


<210> 115
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide

<400> 115
gatccccggg taccggtcgg cgcgcctcga gatatcttaa ttaag                     45


<210> 116
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 116
aattcttaat taagatatct cgaggcgcgc cgaccggtac ccggg                     45


<210> 117
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 117
gagccatggg gccggagccg cagtgagcac catg                                 34


<210> 118
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 118
ccagatccaa gcaccttcac cttcctcagc tccg                                 34


<210> 119
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 119
gcccaaccag gcgcagatgc ggatcctgaa agag                                 34


<210> 120
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 120
tcggggcttc tgcggacttg gccttctggt tcac                                 34


<210> 121
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 121
ggatccgcgg ccgcaccatg agggtccccg ctcagctcct ggggctcctt ctgctctgg      59


<210> 122
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 122
cctggggctc cttctgctct ggctccctgg agccagatgt gacatccaga tgacccagtc     60


<210> 123
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 123
agccaccgta cgtttgatct ccaccttggt acc                                  33


<210> 124
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 124
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcag                                       89


<210> 125
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 125
tgagacccac tccagcccct tccctggagc ctggcggacc                           40


<210> 126
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 126
tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg     60

tatctgcaaa tgaacagcct gagagccgag gac                                  93


<210> 127
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 127
tctggattca ccttcagtag ctatggcatg gtctgggtcc gccaggctcc                50


<210> 128
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 128
gggctggagt gggtctcatc cattagttct tctggtggcc tgacatggta cgcagactcc     60

gtgaag                                                                66


<210> 129
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 129
tgaggagacg gtgaccaggg ttccctggcc ccagtagtcc cgagcaacgg caataccggg     60

ggggctcgca cagtaataca cggccgtgtc ctcggctctc ag                       102


<210> 130
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 130
gttgctacgc gtgtcctgtc cgaggtgcag ctgttggag                            39


<210> 131
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 131
cttggtgcta gctgaggaga cggtgac                                         27


<210> 132
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 132
Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro 
1               5                   10                  15      


Ala Gly Ser Trp Gln Glu Arg Arg Ser His Glu Val 
            20                  25              


<210> 133
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 133
Gly Gly Gly Gly Ser Leu His Trp Arg Leu Gly Glu Met Val Thr Arg 
1               5                   10                  15      


Leu Pro Asp Gly Pro Ala Gly Ser Trp Gln Glu Arg Arg Ser His Glu 
            20                  25                  30          


Val 
    


<210> 134
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 134
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 135
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 135
cttccccgaa ccggtgacgg tg                                              22


<210> 136
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 136
gggcagggat cctcacacca tgaaagcccc gaagtaag                             38


<210> 137
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 137
gcctgcctga cggacctgca ggctcctggc aagagcgaag gtctcacgag gtcaacccag     60

cagcgcatct c                                                          71


<210> 138
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 138
caggtccgtc aggcaggcgg gtgaccatct ctcctagacg ccagtgcagt ttgtcacaag     60

atttgg                                                                66


<210> 139
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 139
tgcaggtccg tcaggcaggc gggtgaccat ctctcctaga cgccagtgca gggaccctcc     60

accgcctttg tcacaagatt tgg                                             83


<210> 140
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 140
ggcggatctg ggggcggcgg gtccggtggt ggtggtagta acccagcagc gcatctc        57


<210> 141
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 141
ccgccgcccc cagatccgcc cccaccggac cctccaccgc ctttgtcaca agatttgg       58


<210> 142
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 142
tggtgggtcc ggcggtggtg ggtccaaccc agcagcgcat ctcac                     45


<210> 143
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      oligonucleotide 

<400> 143
agagagggat ccgcggccgc tcagtgatgg tgatggtggt gatgatgatg atgtcctccc     60

accatgaaag ccccgaag                                                   78


<210> 144

<400> 144
000

<210> 145
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<220>
<223> This sequence may encompass one to five
      "Gly Gly Gly Gly Ser" repeating units

<400> 145
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 146
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 146
Gly Gly Gly Gly Ser 
1               5   


<210> 147
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 147
Gly Gly Gly Gly Ser 
1               5   


<210> 148
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 148
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 149
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide

<220>
<223> This sequence may encompass one to eight
      "Gly Gly Gly Gly Ser" repeating units

<400> 149
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210> 150
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      6x His tag

<400> 150
His His His His His His 
1               5       


<210> 151
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide

<400> 151
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 152

<400> 152
000

<210> 153
<211> 1350
<212> DNA
<213> Homo sapiens

<400> 153
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc    300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctcagct    360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc    900

gcctaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaatga                                    1350


<210> 154
<211> 449
<212> PRT
<213> Homo sapiens

<400> 154
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Ala Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 155
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 155
gaggagcagt acaacagcgc ctaccgtgtg gtcagcgtc                            39


<210> 156
<211> 357
<212> DNA
<213> Homo sapiens

<400> 156
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc    300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctca       357


<210> 157
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 157
gttgctacgc gtgtcctgtc cgaggtgcag ctgttggag                              39


<210> 158
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 158
gctcttggag gagggtgcca gggggaagac cgatgggccc ttggtgctag cgcttgagac       60

ggtgaccatg gttc                                                         74


<210> 159
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 159
accgtcaccg gttcggggaa gtagtccttc accaggcagc ccagggcggc ggtgccgccg       60

ctggtgctct tgctgctggg ggccagg                                           87


<210> 160
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 160
acgcgt                                                                   6


<210> 161
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 161
accggt                                                                   6


<210> 162
<211> 1182
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 162
gaggtgcagc tgttggagtc cggcggtggc ctggtgcagc ctggggggtc cctgagactc       60

tcctgcgcag ctagcggctt caccttcagc atttaccgta tgcagtgggt gcgccaggct      120

cctggaaagg ggctggagtg ggtttccggt atctctccct ctggtggcac gacgtggtat      180

gctgactccg tgaagggccg gttcacaatc tccagagaca attccaagaa cactctgtac      240

ctgcaaatga acagcctgag agctgaggat actgcagtgt actactgcgc cagatggtcc      300

gggggctccg gatacgcctt cgacatctgg ggacagggaa ccatggtcac cgtctcaagc      360

gcctcaacga aggggcccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaggcgg tggagggtcc ggtgggggcg gatctggggg cggcgggtcc      720

ggtggtggtg gtagtaaccc agcagcgcat ctcacagggg ccaactccag cttgaccggc      780

agcggggggc cgctgttatg ggagactcag ctgggcctgg ccttcctgag gggcctcagc      840

taccacgatg gggcccttgt ggtcaccaaa gctggctact actacatcta ctccaaggtg      900

cagctgggcg gtgtgggctg cccgctgggc ctggccagca ccatcaccca cggcctctac      960

aagcgcacac cccgctaccc cgaggagctg gagctgttgg tcagccagca gtcaccctgc     1020

ggacgggcca ccagcagctc ccgggtctgg tgggacagca gcttcctggg tggtgtggta     1080

cacctggagg ctggggagga ggtggtcgtc cgtgtgctgg atgaacgcct ggttcgactg     1140

cgtgatggta cccggtctta cttcggggct ttcatggtgt ga                        1182


<210> 163
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 163
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Arg Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Pro Ser Gly Gly Thr Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Gly Gly Ser Gly Tyr Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser 
                245                 250                 255     


Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly 
            260                 265                 270         


Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val 
        275                 280                 285             


Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly 
    290                 295                 300                 


Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr 
305                 310                 315                 320 


Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln 
                325                 330                 335     


Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp 
            340                 345                 350         


Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val 
        355                 360                 365             


Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr 
    370                 375                 380                 


Arg Ser Tyr Phe Gly Ala Phe Met Val 
385                 390             


<210> 164
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 164
Ile Tyr Arg Met Gln 
1               5   


<210> 165
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 165
Gly Ile Ser Pro Ser Gly Gly Thr Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 166
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 166
Trp Ser Gly Gly Ser Gly Tyr Ala Phe Asp Ile 
1               5                   10      


<210> 167
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 167
gacatccaga tgacccagtc tccactctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtcg ggacattaga aactatttaa attggtatca acaaaaacca      120

gggaaagccc cgaagctcct gatctacgat gcatccagtt tgcaaacagg ggtcccatca      180

aggttcggtg gcagtggatc tgggacagac tttagtttca ccatcggcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tttgatagtc tccctcacac ttttggccag      300

gggaccaaac tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210> 168
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 168
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Gly Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Asp Ser Leu Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 169
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 169
Gln Ala Ser Arg Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210> 170
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 170
Asp Ala Ser Ser Leu Gln Thr 
1               5           


<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 171
Gln Gln Phe Asp Ser Leu Pro His Thr 
1               5                   


<210> 172
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 172
Thr His Thr Cys Pro Pro Cys Pro 
1               5               


<210> 173
<211> 1176
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 173
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccgggtt caggttcacc ttcaataact actacatgga ctgggtccgc      120

caggctccag ggcaggggct ggagtgggtc tcacgtatta gtagtagtgg tgatcccaca      180

tggtacgcag actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca      240

ctgtttcttc aaatgaacag cctgagagct gaggacacgg ctgtctatta ctgtgcgagc      300

ttgactacag ggtctgactc ctggggccag ggagtcctgg tcaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaag gcggtggagg gtccggtggg ggcggatctg ggggcggcgg gtccggtggt      720

ggtggtagta acccagcagc gcatctcaca ggggccaact ccagcttgac cggcagcggg      780

gggccgctgt tatgggagac tcagctgggc ctggccttcc tgaggggcct cagctaccac      840

gatggggccc ttgtggtcac caaagctggc tactactaca tctactccaa ggtgcagctg      900

ggcggtgtgg gctgcccgct gggcctggcc agcaccatca cccacggcct ctacaagcgc      960

acaccccgct accccgagga gctggagctg ttggtcagcc agcagtcacc ctgcggacgg     1020

gccaccagca gctcccgggt ctggtgggac agcagcttcc tgggtggtgt ggtacacctg     1080

gaggctgggg aggaggtggt cgtccgtgtg ctggatgaac gcctggttcg actgcgtgat     1140

ggtacccggt cttacttcgg ggctttcatg gtgtga                               1176


<210> 174
<211> 391
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 174
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu 
                245                 250                 255     


Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala 
            260                 265                 270         


Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys 
        275                 280                 285             


Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly 
    290                 295                 300                 


Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg 
305                 310                 315                 320 


Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser 
                325                 330                 335     


Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser 
            340                 345                 350         


Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val 
        355                 360                 365             


Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser 
    370                 375                 380                 


Tyr Phe Gly Ala Phe Met Val 
385                 390     


<210> 175
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 175
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccaggcgg tggagggtcc       60

ggtgg                                                                   65


<210> 176
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 176
ccaccggacc ctccaccgcc tgggcacggt gggcatgtgt gagttttgtc acaagatttg       60

ggctc                                                                   65


<210> 177
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 177
ggatcc                                                                   6


<210> 178
<211> 1203
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 178
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc      300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccaggcg gtggagggtc cggtgggggc      720

ggatctgggg gcggcgggtc cggtggtggt ggtagtaacc cagcagcgca tctcacaggg      780

gccaactcca gcttgaccgg cagcgggggg ccgctgttat gggagactca gctgggcctg      840

gccttcctga ggggcctcag ctaccacgat ggggcccttg tggtcaccaa agctggctac      900

tactacatct actccaaggt gcagctgggc ggtgtgggct gcccgctggg cctggccagc      960

accatcaccc acggcctcta caagcgcaca ccccgctacc ccgaggagct ggagctgttg     1020

gtcagccagc agtcaccctg cggacgggcc accagcagct cccgggtctg gtgggacagc     1080

agcttcctgg gtggtgtggt acacctggag gctggggagg aggtggtcgt ccgtgtgctg     1140

gatgaacgcc tggttcgact gcgtgatggt acccggtctt acttcggggc tttcatggtg     1200

tga                                                                   1203


<210> 179
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 179
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Pro Ala Ala 
                245                 250                 255     


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            260                 265                 270         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        275                 280                 285             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    290                 295                 300                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
305                 310                 315                 320 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                325                 330                 335     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            340                 345                 350         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        355                 360                 365             


Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu 
    370                 375                 380                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
385                 390                 395                 400 


<210> 180
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 180
gcggccgc                                                                 8


<210> 181
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 181
cgtacg                                                                   6


<210> 182
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 182
gctagc                                                                   6


<210> 183
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(25)
<223> This region may encompass 1 to 5 "Gly Gly Gly Gly Ser"
      repeating units

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 183
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 184
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> misc_feature
<222> (1)..(25)
<223> This region may encompass 1 to 5 "Gly Gly Gly Gly Ser"
      repeating units

<220>
<221> misc_feature
<222> (26)..(40)
<223> This region may encompass 1 to 5 "Asn Xaa Ser"
      repeating units

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 184
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Xaa Ser Asn Xaa Ser Asn 
            20                  25                  30          


Xaa Ser Asn Xaa Ser Asn Xaa Ser 
        35                  40  


<210> 185
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> misc_feature
<222> (1)..(15)
<223> This region may encompass 1 to 5 "Asn Xaa Ser"
      repeating units

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> misc_feature
<222> (16)..(40)
<223> This region may encompass 1 to 5 "Gly Gly Gly Gly Ser"
      repeating units

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 185
Asn Xaa Ser Asn Xaa Ser Asn Xaa Ser Asn Xaa Ser Asn Xaa Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210> 186
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 186
Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val 
1               5                   10              


<210> 187
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 187
Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val 
1               5                   10                  15  


<210> 188
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 188
Gly Gly Gly Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His 
1               5                   10                  15      


Glu Val Asn Pro Ala 
            20      


<210> 189
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 189
Gly Gly Gly Gly Ser Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg 
1               5                   10                  15      


Ser His Glu Val Asn Pro Ala 
            20              


<210> 190
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 190
Gly Gly Gly Gly Ser Asn Ser Ser Trp Glu Gln Leu Ile Gln Glu Arg 
1               5                   10                  15      


Arg Ser His Glu Val Asn Pro Ala 
            20                  


<210> 191
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 191
Gly Gly Gly Gly Ser Asn Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg 
1               5                   10                  15      


Arg Ser His Glu Val Asn Pro Ala 
            20                  


<210> 192
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 192
Asn Ser Ser Gly Gly Gly Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg 
1               5                   10                  15      


Arg Ser His Glu Val Asn Pro Ala 
            20                  


<210> 193
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 193
Gly Gly Gly Gly Ser Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg 
1               5                   10                  15      


Arg Ser His Glu Val Asn Pro Ala 
            20                  


<210> 194
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 194
Gly Gly Gly Gly Ser Trp Glu Gln Leu Ile Gln Glu Asn Arg Ser His 
1               5                   10                  15      


Glu Val Asn Pro Ala 
            20      


<210> 195
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 195
catggcggcc gcccggagcc gcagtgatca tc                                     32


<210> 196
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 196
cgatgcggcc gcggatgtct gcacatgtga cc                                     32


<210> 197
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 197
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tggtctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagttctt ctggtggcct gacatggtac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagccccccc      300

ggtattgccg ttgctcggga ctactggggc cagggaaccc tggtcaccgt ctcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaatga                                      1350


<210> 198
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 198
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Pro Gly Ile Ala Val Ala Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 199
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 199
Asn Gln Thr Tyr Ile Cys 
1               5                       


