                         SEQUENCE LISTING

<110>  Slack, Jay
       Evans, Jenny
 
<120>  Methods to identify modulators

<130>  30502

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(924)

<400>  1
atg caa gca gca ctg acg gcc ttc ttc gtg ttg ctc ttt agc ctg ctg       48
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu         
1               5                   10                  15              

agt ctt ctg ggg att gca gcg aat ggc ttc att gtg ctg gtg ctg ggc       96
Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly         
            20                  25                  30                  

agg gag tgg ctg cga tat ggc agg ttg ctg ccc ttg gat atg atc ctc      144
Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu         
        35                  40                  45                      

att agc ttg ggt gcc tcc cgc ttc tgc ctg cag ttg gtt ggg aca gtg      192
Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val         
    50                  55                  60                          

cac aac ttc tac tac tct gcc cag aag gtc gag tac tct ggg ggt ctc      240
His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu         
65                  70                  75                  80          

ggc cga cag ttc ttc cat cta cac tgg cac ttc ctg aac tca gcc acc      288
Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr         
                85                  90                  95              

ttc tgg ttt tgc agc tgg ctc agt gtc ctg ttc tgt gtg aag att gct      336
Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala         
            100                 105                 110                 

aac atc aca cac tcc acc ttc ctg tgg ctg aag tgg agg ttc cca ggg      384
Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly         
        115                 120                 125                     

tgg gtg ccc tgg ctc ctg ttg ggc tct gtc ctg atc tcc ttc atc ata      432
Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile         
    130                 135                 140                         

acc ctg ctg ttt ttt tgg gtg aac tac cct gta tat caa gaa ttt tta      480
Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu         
145                 150                 155                 160         

att aga aaa ttt tct ggg aac atg acc tac aag tgg aat aca agg ata      528
Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile         
                165                 170                 175             

gaa aca tac tat ttc cca tcc ctg aaa ctg gtc atc tgg tca att cct      576
Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro         
            180                 185                 190                 

ttt tct gtt ttt ctg gtc tca att atg ctg tta att aat tct ctg agg      624
Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg         
        195                 200                 205                     

agg cat act cag aga atg cag cac aac ggg cac agc ctg cag gac ccc      672
Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro         
    210                 215                 220                         

agc gcc cag gct cac acc aga gct ctg aag tcc ctc atc tcc ttc ctc      720
Ser Ala Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu         
225                 230                 235                 240         

att ctt tat gct ctg tcc ttt ctg tcc ctg atc att gat gcc gca aaa      768
Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys         
                245                 250                 255             

ttt atc tcc atg cag aac gac ttt tac tgg cca tgg caa att gca gtc      816
Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val         
            260                 265                 270                 

tac ctg tgc ata tct gtc cat ccc ttc atc ctc atc ttc agc aac ctc      864
Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu         
        275                 280                 285                     

aag ctt cga agc gtg ttc tcg cag ctc ctg ttg ttg gca agg ggc ttc      912
Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe         
    290                 295                 300                         

tgg gtg gcc tga                                                      924
Trp Val Ala                                                             
305                                                                     


<210>  2
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Ala Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  3
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(924)

<400>  3
atg caa gca gca ctg acg gcc ttc ttc gtg ttg ctc ttt agc ctg ctg       48
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu         
1               5                   10                  15              

agt ctt ctg ggg att gca gcg aat ggc ttc att gtg ctg gtg ctg ggc       96
Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly         
            20                  25                  30                  

agg gag tgg ctg cga tat ggc agg ttg ctg ccc ttg gat atg atc ctc      144
Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu         
        35                  40                  45                      

att agc ttg ggt gcc tcc cgc ttc tgc ctg cag ttg gtt ggg acg gtg      192
Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val         
    50                  55                  60                          

cac aac ttc tac tac tct gcc cag aag gtc gag tac tct ggg ggt ctc      240
His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu         
65                  70                  75                  80          

ggc cga cag ttc ttc cat cta cac tgg cac ttc ctg aac tca gcc acc      288
Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr         
                85                  90                  95              

ttc tgg ttt tgc agc tgg ctc agt gtc ctg ttc tgt gtg aag att gct      336
Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala         
            100                 105                 110                 

aac atc aca cac tcc acc ttc ctg tgg ctg aag tgg agg ttc cca ggg      384
Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly         
        115                 120                 125                     

tgg gtg ccc tgg ctc ctg ttg ggc tct gtc ctg atc tcc ttc atc ata      432
Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile         
    130                 135                 140                         

acc ctg ctg ttt ttt tgg gtg aac tac cct gta tat caa gaa ttt tta      480
Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu         
145                 150                 155                 160         

att aga aaa ttt tct ggg aac atg acc tac aag tgg aat aca agg ata      528
Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile         
                165                 170                 175             

gaa aca tac tat ttc cca tcc ctg aaa ctg gtc atc tgg tca att cct      576
Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro         
            180                 185                 190                 

ttt tct gtt ttt ctg gtc tca att atg ctg tta att aat tct ctg agg      624
Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg         
        195                 200                 205                     

agg cat act cag aga atg cag cac aac ggg cac agc ctg cag gac ccc      672
Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro         
    210                 215                 220                         

agc gcc cag gct cac acc aga gct ctg aag tcc ctc atc tcc ttc ctc      720
Ser Ala Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu         
225                 230                 235                 240         

att ctt tat gct ctg tcc ttt ctg tcc ctg atc att gat gcc gca aaa      768
Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys         
                245                 250                 255             

ttt atc tcc atg cag aac gac ttt tac tgg cca tgg caa att gca gtc      816
Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val         
            260                 265                 270                 

tac ctg tgc ata tct gtc cat ccc ttc atc ctc atc ttc agc aac ctc      864
Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu         
        275                 280                 285                     

aag ctt cga agc gtg ttc tcg cag ctc ctg ttg ttg gca agg ggc ttc      912
Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe         
    290                 295                 300                         

tgg gtg gcc tga                                                      924
Trp Val Ala                                                             
305                                                                     


<210>  4
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Ala Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  5
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(924)

<400>  5
atg caa gca gca ctg acg gcc ttc ttc gtg ttg ctc ttt agc ctg ctg       48
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu         
1               5                   10                  15              

agt ctt ctg ggg att gca gcg aat ggc ttc att gtg ctg gtg ctg ggc       96
Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly         
            20                  25                  30                  

agg gag tgg ctg cga tat ggc agg ttg ctg ccc ttg gat atg atc ctc      144
Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu         
        35                  40                  45                      

att agc ttg ggt gcc tcc cgc ttc tgc ctg cag ttg gtt ggg acg gtg      192
Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val         
    50                  55                  60                          

cac aac ttc tac tac tct gcc cag aag gtc gag tac tct ggg ggt ctc      240
His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu         
65                  70                  75                  80          

ggc cga cag ttc ttc cat cta cac tgg cac ttc ctg aac tca gcc acc      288
Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr         
                85                  90                  95              

ttc tgg ttt tgc agc tgg ctc agt gtc ctg ttc tgt gtg aag att gct      336
Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala         
            100                 105                 110                 

aac atc aca cac tcc acc ttc ctg tgg ctg aag tgg agg ttc cca ggg      384
Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly         
        115                 120                 125                     

tgg gtg ccc tgg ctc ctg ttg ggc tct gtc ctg atc tcc ttc atc ata      432
Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile         
    130                 135                 140                         

acc ctg ctg ttt ttt tgg gtg aac tac cct gta tat caa gaa ttt tta      480
Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu         
145                 150                 155                 160         

att aga aaa ttt tct ggg aac atg acc tac aag tgg aat aca agg ata      528
Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile         
                165                 170                 175             

gaa aca tac tat ttc cca tcc ctg aaa ctg gtc atc tgg tca att cct      576
Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro         
            180                 185                 190                 

ttt tct gtt ttt ctg gtc tca att atg ctg tta att aat tct ctg agg      624
Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg         
        195                 200                 205                     

agg cat act cag aga atg cag cac aac ggg cac agc ctg cag gac ccc      672
Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro         
    210                 215                 220                         

agc acc cag gct cac acc aga gct ctg aag tcc ctc atc tcc ttc ctc      720
Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu         
225                 230                 235                 240         

att ctt tat gct ctg tcc ttt ctg tcc ctg atc att gat gcc gca aaa      768
Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys         
                245                 250                 255             

ttt atc tcc atg cag aac gac ttt tac tgg cca tgg caa att gca gtc      816
Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val         
            260                 265                 270                 

tac ctg tgc ata tct gtc cat ccc ttc atc ctc atc ttc agc aac ctc      864
Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu         
        275                 280                 285                     

aag ctt cga agc gtg ttc tcg cag ctc ctg ttg ttg gca agg ggc ttc      912
Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe         
    290                 295                 300                         

tgg gtg gcc tga                                                      924
Trp Val Ala                                                             
305                                                                     


<210>  6
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  7
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(924)

<400>  7
atg caa gca gca ctg acg gcc ttc ttc gtg ttg ctc ttt agc ctg ctg       48
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu         
1               5                   10                  15              

agt ctt ctg ggg att gca gcg aat ggc ttc att gtg ctg gtg ctg ggc       96
Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly         
            20                  25                  30                  

agg gag tgg ctg cga tat ggc agg ttg ctg ccc ttg gat atg atc ctc      144
Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu         
        35                  40                  45                      

att agc ttg ggt gcc tcc cgc ttc tgc ctg cag ttg gtt ggg aca gtg      192
Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val         
    50                  55                  60                          

cac aac ttc tac tac tct gcc cag aag gtc gag tac tct ggg ggt ctc      240
His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu         
65                  70                  75                  80          

ggc cga cag ttc ttc cat cta cac tgg cac ttc ctg aac tca gcc acc      288
Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr         
                85                  90                  95              

ttc tgg ttt tgc agc tgg ctc agt gtc ctg ttc tgt gtg aag att gct      336
Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala         
            100                 105                 110                 

aac atc aca cac tcc acc ttc ctg tgg ctg aag tgg agg ttc cta ggg      384
Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Leu Gly         
        115                 120                 125                     

tgg gtg ccc tgg ctc ctg ttg ggc tct gtc ctg atc tcc ttc atc ata      432
Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile         
    130                 135                 140                         

acc ctg ctg ttt ttt tgg gtg aac tac cct gta tat caa gaa ttt tta      480
Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu         
145                 150                 155                 160         

att aga aaa ttt tct ggg aac atg acc tac aag tgg aat aca agg ata      528
Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile         
                165                 170                 175             

gaa aca tac tat ttc cca tcc ctg aaa ctg gtc atc tgg tca att cct      576
Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro         
            180                 185                 190                 

ttt tct gtt ttt ctg gtc tca att atg ctg tta att aat tct ctg agg      624
Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg         
        195                 200                 205                     

agg cat act cag aga atg cag cac aac ggg cac agc ctg cag gac ccc      672
Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro         
    210                 215                 220                         

agc acc cag gct cac acc aga gct ctg aag tcc ctc atc tcc ttc ctc      720
Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu         
225                 230                 235                 240         

att ctt tat gct ctg tcc ttt ctg tcc ctg atc att gat gcc gca aaa      768
Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys         
                245                 250                 255             

ttt atc tcc atg cag aac gac ttt tac tgg cca tgg caa att gca gtc      816
Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val         
            260                 265                 270                 

tac ctg tgc ata tct gtc cat ccc ttc atc ctc atc ttc agc aac ctc      864
Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu         
        275                 280                 285                     

aag ctt cga agc gtg ttc tcg cag ctc ctg ttg ttg gca agg ggc ttc      912
Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe         
    290                 295                 300                         

tgg gtg gcc tga                                                      924
Trp Val Ala                                                             
305                                                                     


<210>  8
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Leu Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  9
<211>  141
<212>  DNA
<213>  Rattus rattus


<220>
<221>  CDS
<222>  (1)..(141)

<400>  9
gcc acc atg gcc gct gtt acc tat cct tca tcc gtg cct acg acc ttg       48
Ala Thr Met Ala Ala Val Thr Tyr Pro Ser Ser Val Pro Thr Thr Leu         
1               5                   10                  15              

gac cct ggg aat gca tcc tca gcc tgg ccc ctg gac acg tcc ctg ggg       96
Asp Pro Gly Asn Ala Ser Ser Ala Trp Pro Leu Asp Thr Ser Leu Gly         
            20                  25                  30                  

aat gca tct gct ggc act agc ctg gca gga ctg gct gtc agt ggc          141
Asn Ala Ser Ala Gly Thr Ser Leu Ala Gly Leu Ala Val Ser Gly             
        35                  40                  45                      


<210>  10
<211>  47
<212>  PRT
<213>  Rattus rattus

<400>  10

Ala Thr Met Ala Ala Val Thr Tyr Pro Ser Ser Val Pro Thr Thr Leu 
1               5                   10                  15      


Asp Pro Gly Asn Ala Ser Ser Ala Trp Pro Leu Asp Thr Ser Leu Gly 
            20                  25                  30          


Asn Ala Ser Ala Gly Thr Ser Leu Ala Gly Leu Ala Val Ser Gly 
        35                  40                  45          


<210>  11
<211>  36
<212>  DNA
<213>  herpes simplex virus


<220>
<221>  CDS
<222>  (1)..(36)

<400>  11
cag cct gaa ctc gct cct gaa gac ccg gaa gat taa                       36
Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp                             
1               5                   10                                  


<210>  12
<211>  11
<212>  PRT
<213>  herpes simplex virus

<400>  12

Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10      


