                         SEQUENCE LISTING

<110>  NETRIS PHARMA
       CNRS (Paris)
       UNIVERSITE DE LA MEDITERRANEE
 
<120>  Antagonists of Sema3E/PlexinD1 interaction as anti-cancer agents

<130>  BET10L0712

<160>  27    

<170>  PatentIn version 3.4

<210>  1
<211>  471
<212>  PRT
<213>  homo sapiens

<400>  1

Asn Asn Phe Ala Leu Asp Gly Ala Ala Gly Thr Val Tyr Leu Ala Ala 
1               5                   10                  15      


Val Asn Arg Leu Tyr Gln Leu Ser Gly Ala Asn Leu Ser Leu Glu Ala 
            20                  25                  30          


Glu Ala Ala Val Gly Pro Val Pro Asp Ser Pro Leu Cys His Ala Pro 
        35                  40                  45              


Gln Leu Pro Gln Ala Ser Cys Glu His Pro Arg Arg Leu Thr Asp Asn 
    50                  55                  60                  


Tyr Asn Lys Ile Leu Gln Leu Asp Pro Gly Gln Gly Leu Val Val Val 
65                  70                  75                  80  


Cys Gly Ser Ile Tyr Gln Gly Phe Cys Gln Leu Arg Arg Arg Gly Asn 
                85                  90                  95      


Ile Ser Ala Val Ala Val Arg Phe Pro Pro Ala Ala Pro Pro Ala Glu 
            100                 105                 110         


Pro Val Thr Val Phe Pro Ser Met Leu Asn Val Ala Ala Asn His Pro 
        115                 120                 125             


Asn Ala Ser Thr Val Gly Leu Val Leu Pro Pro Ala Ala Gly Ala Gly 
    130                 135                 140                 


Gly Ser Arg Leu Leu Val Gly Ala Thr Tyr Thr Gly Tyr Gly Ser Ser 
145                 150                 155                 160 


Phe Phe Pro Arg Asn Arg Ser Leu Glu Asp His Arg Phe Glu Asn Thr 
                165                 170                 175     


Pro Glu Ile Ala Ile Arg Ser Leu Asp Thr Arg Gly Asp Leu Ala Lys 
            180                 185                 190         


Leu Phe Thr Phe Asp Leu Asn Pro Ser Asp Asp Asn Ile Leu Lys Ile 
        195                 200                 205             


Lys Gln Gly Ala Lys Glu Gln His Lys Leu Gly Phe Val Ser Ala Phe 
    210                 215                 220                 


Leu His Pro Ser Asp Pro Pro Pro Gly Ala Gln Ser Tyr Ala Tyr Leu 
225                 230                 235                 240 


Ala Leu Asn Ser Glu Ala Arg Ala Gly Asp Lys Glu Ser Gln Ala Arg 
                245                 250                 255     


Ser Leu Leu Ala Arg Ile Cys Leu Pro His Gly Ala Gly Gly Asp Ala 
            260                 265                 270         


Lys Lys Leu Thr Glu Ser Tyr Ile Gln Leu Gly Leu Gln Cys Ala Gly 
        275                 280                 285             


Gly Ala Gly Arg Gly Asp Leu Tyr Ser Arg Leu Val Ser Val Phe Pro 
    290                 295                 300                 


Ala Arg Glu Arg Leu Phe Ala Val Phe Glu Arg Pro Gln Gly Ser Pro 
305                 310                 315                 320 


Ala Ala Arg Ala Ala Pro Ala Ala Leu Cys Ala Phe Arg Phe Ala Asp 
                325                 330                 335     


Val Arg Ala Ala Ile Arg Ala Ala Arg Thr Ala Cys Phe Val Glu Pro 
            340                 345                 350         


Ala Pro Asp Val Val Ala Val Leu Asp Ser Val Val Gln Gly Thr Gly 
        355                 360                 365             


Pro Ala Cys Glu Arg Lys Leu Asn Ile Gln Leu Gln Pro Glu Gln Leu 
    370                 375                 380                 


Asp Cys Gly Ala Ala His Leu Gln His Pro Leu Ser Ile Leu Gln Pro 
385                 390                 395                 400 


Leu Lys Ala Thr Pro Val Phe Arg Ala Pro Gly Leu Thr Ser Val Ala 
                405                 410                 415     


Val Ala Ser Val Asn Asn Tyr Thr Ala Val Phe Leu Gly Thr Val Asn 
            420                 425                 430         


Gly Arg Leu Leu Lys Ile Asn Leu Asn Glu Ser Met Gln Val Val Ser 
        435                 440                 445             


Arg Arg Val Val Thr Val Ala Tyr Gly Glu Pro Val His His Val Met 
    450                 455                 460                 


Gln Phe Asp Pro Ala Asp Ser 
465                 470     


<210>  2
<211>  1413
<212>  DNA
<213>  homo sapiens

<400>  2
aacaacttcg ccctggacgg cgcggcgggg accgtgtacc tggcggccgt caaccgcctc     60

tatcagctgt cgggcgccaa cctgagcctg gaggccgagg cggccgtggg cccggtgccc    120

gacagcccgc tgtgtcacgc tccgcagctg ccgcaggcct cgtgcgagca cccgcggcgc    180

ctcacggaca actacaacaa gatcctgcag ctggaccccg gccagggcct ggtagtcgtg    240

tgcgggtcca tctaccaggg cttctgccag ctgcggcgcc ggggcaacat ctcggccgtg    300

gccgtgcgct tcccgcccgc cgcgccgccc gccgagcccg tcacggtgtt ccccagcatg    360

ctgaacgtgg cggccaacca cccgaacgcg tccaccgtgg ggctagttct gcctcccgcc    420

gcgggcgcgg ggggcagccg cctgctcgtg ggcgccacgt acaccggtta cggcagctcc    480

ttcttcccgc gcaaccgcag cctggaggac caccgcttcg agaacacgcc cgagatcgcc    540

atccgctccc tggacacgcg cggcgacctg gccaagctct tcaccttcga cctcaacccc    600

tccgacgaca acatcctcaa gatcaagcag ggcgccaagg agcagcacaa gctgggcttc    660

gtgagcgcct tcctgcaccc gtccgacccg ccgccgggtg cacagtccta cgcgtacctg    720

gcgctcaaca gcgaggcgcg cgcgggcgac aaggagagcc aggcgcggag cctgctggcg    780

cgcatctgcc tgccccacgg cgccggcggc gacgccaaga agctcaccga gtcctacatc    840

cagttgggct tgcagtgcgc gggcggcgcg ggccgcggcg acctctacag ccgcctggtg    900

tcggtcttcc cagcccggga gcggctcttt gctgtcttcg agcggcccca ggggtccccc    960

gcggcccgcg ctgctccggc cgcactctgc gccttccgct tcgccgacgt gcgagccgcc   1020

atccgagctg cgcgcaccgc ctgcttcgtg gaaccggcgc ccgacgtggt ggcggtgctc   1080

gacagcgtgg tgcagggcac gggaccggcc tgcgagcgca agctcaacat ccagctccag   1140

ccagagcagc tggactgtgg agctgctcac ctgcagcacc cgctgtccat cctgcagccc   1200

ctgaaggcca cgcccgtgtt ccgcgccccg ggcctcacct ccgtggccgt ggccagcgtc   1260

aacaactaca cagcggtctt cctgggcacg gtcaacggga ggcttctcaa gatcaacctg   1320

aacgagagca tgcaggtggt gagcaggcgg gtggtgactg tggcctatgg ggagcccgtg   1380

caccatgtca tgcagtttga cccagcagac tcc                                1413


<210>  3
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  4
tgtatgggcg aataactcac tg                                              22


<210>  5
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  5
tcattccaaa cacagaggtg ac                                              22


<210>  6
<211>  56
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  6
ggggaccact ttgtacaaga aagctgggtc ctaggagagc agcgtgtgcc tgggca         56


<210>  7
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  7
ggggacaagt ttgtacaaaa agcaggcttc gcgaacccct cctaccccag gct            53


<210>  8
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  8
acccagaaga ctgtggatgg                                                 20


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  9
ggagacaacc tggtcctcag                                                 20


<210>  10
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  10
ccatcgatta atggctcgtc gcgcgcgggc                                      30


<210>  11
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  11
ggatcgatga tccatggggt caaactgcat                                      30


<210>  12
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  12
ccatcgatta atggagacag acacactcct                                      30


<210>  13
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  13
agttaaaacc gtacgcgtca ccagtggaag gt                                   32


<210>  14
<211>  63
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  14
ggggacaagt ttgtacaaaa aagcaggctt cttctgtacc aagagccgac gtgctgagcg     60

tta                                                                   63


<210>  15
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  15
ggggaccact ttgtacaaga aagctgggtc ggcctcactg tagcactcgt agatgttgtc     60

ctccatcaaa                                                            70


<210>  16
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  16
ggacctcatt aacgcctcgg ccgccaagaa ccccaa                               36


<210>  17
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  17
cggccgaggc gttaatgagg tccaccagca gctccttc                             38


<210>  18
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  18
ggacctggac aacacctcag tggtggaaga cggcc                                35


<210>  19
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  19
ccactgaggt gttgtccagg tcccgaagga tgtagctc                             38


<210>  20
<211>  55
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  20
ggggacaagt ttgtacaaaa aagcaggctt cgcctcggcc gccaagaacc ccaag          55


<210>  21
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  21
ggggaccact ttgtacaaga aagctgggtc ctagtcgtcc aggtcccgaa ggatgta        57


<210>  22
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  22
catgctggcc gccacagagt ctgtggtgga gaagatgctc acc                       43


<210>  23
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  23
ctctgtggcg gccagcatga gcttggggtt cttggcggcc                           40


<210>  24
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  24
cctctcgcct tctgggtgaa catcctgaac ccccagt                              37


<210>  25
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  25
ccagaaggcg agaggaaggc tgttggtctt ccagatgtgt                           40


<210>  26
<211>  58
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  26
ccgggctgct gaaagtaatc acaatctcga gattgtgatt actttcagca gctttttg       58


<210>  27
<211>  58
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  27
ccggccttgt ctattccctg aacttctcga gaagttcagg gaatagacaa ggtttttg       58


