                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Mnchen
       ZEIDLER, Reinhard
 
<120>  NOVEL ANTIBODY TO A CARBONIC ANHYDRASE

<130>  S1687 PCT

<150>  EP10004646.5
<151>  2010-05-03

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Arg Ala Ser Gln Gly Ile Ser Thr Ser Ile His 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Phe Ala Ser Gln Ser Ile Ser 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Gln Gln Thr Tyr Ser Leu Pro Tyr Thr Phe 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Gly Phe Ser Leu Thr Thr Tyr Ser Val Ser 
1               5                   10  


<210>  5
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Arg Met Trp Tyr Asp Gly Asp Thr Val 
1               5                   


<210>  6
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Asp Phe Gly Tyr Phe Asp Gly Ser Ser Pro Phe Asp Tyr 
1               5                   10              


<210>  7
<211>  173
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Ala Arg Val Phe Gln Gln Asp Asp Ile Val Met Thr Gln Thr Pro 
1               5                   10                  15      


Ala Thr Leu Ser Val Thr Pro Gly Glu Ser Val Ser Leu Ser Cys Arg 
            20                  25                  30          


Ala Ser Gln Gly Ile Ser Thr Ser Ile His Trp Tyr Gln Gln Lys Ser 
        35                  40                  45              


Asn Glu Ser Pro Arg Leu Leu Ile Lys Phe Ala Ser Gln Ser Ile Ser 
    50                  55                  60                  


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Ser Ile Asn Arg Val Glu Ser Glu Asp Phe Ser Val Tyr Phe Cys 
                85                  90                  95      


Gln Gln Thr Tyr Ser Leu Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu 
            100                 105                 110         


Glu Leu Lys Arg Ala Asp Gly Cys Thr Asn Cys Ile His Leu Ser Arg 
        115                 120                 125             


Arg Ser Pro Thr Ile Phe Ser Ala Ala Met Glu Asn Arg Cys Ser Ser 
    130                 135                 140                 


Phe Ile Leu Ser Arg Phe Ser Gly Cys Ile Leu Lys Leu Ile Leu Arg 
145                 150                 155                 160 


Thr Met Leu Thr Thr Ser Ser Gly Thr Val Val Gly Gly 
                165                 170             


<210>  8
<211>  197
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Ser Val Ser Trp Val Arg Gln Pro Ser Gly Lys Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Arg Met Trp Tyr Asp Gly Asp Thr Val Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Glu Thr Asp Glu Thr Gly Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Phe Gly Tyr Phe Asp Gly Ser Ser Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Val Met Val Thr Val Ser Ser Ala Glu Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Thr Ala Leu Lys Ser Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Ile Leu Leu Lys Asn Ser Ser His Pro 
145                 150                 155                 160 


Glu Asp Leu Ala Ala Ala Leu Pro Ile Val Ser Arg Ile Thr Pro Asp 
                165                 170                 175     


Gly Tyr Gly Val Gln Ala Gln Val Leu Lys Gln Leu Ile Leu Phe Thr 
            180                 185                 190         


Met Arg Lys Lys Gln 
        195         


<210>  9
<211>  33
<212>  DNA
<213>  Rattus norvegicus

<400>  9
agggccagtc agggtattag cactagcata cac                                  33


<210>  10
<211>  21
<212>  DNA
<213>  Rattus norvegicus

<400>  10
tttgcttccc agtccatctc t                                               21


<210>  11
<211>  30
<212>  DNA
<213>  Rattus norvegicus

<400>  11
caacagactt acagcttgcc ctacacgttt                                      30


<210>  12
<211>  519
<212>  DNA
<213>  Rattus norvegicus

<400>  12
atggctcgag tttttcagca agatgatatt gtgatgaccc agactccagc caccctgtct     60

gtgactccag gagagagtgt cagtctctcc tgcagggcca gtcagggtat tagcactagc    120

atacactggt atcagcaaaa atcaaatgag tctccaaggc ttctcatcaa atttgcttcc    180

cagtccatct ctggaatccc ctccaggttc agtggcagtg gatcagggac agatttcact    240

ctcagtatca acagagtaga atctgaagat ttttcagttt atttctgtca acagacttac    300

agcttgccct acacgtttgg agctgggacc aagctggaac tgaaacgggc tgatggctgc    360

accaactgta tccatctttc tagaagatct cctacaatat tctcagctgc catggaaaat    420

cgatgttctt cttttattct ctcaagattt tcaggctgta tattaaaact tatattaaga    480

actatgctaa ccacctcatc aggaaccgtt gtaggtggc                           519


<210>  13
<211>  30
<212>  DNA
<213>  Rattus norvegicus

<400>  13
gggttctcac taaccaccta tagtgtaagt                                      30


<210>  14
<211>  27
<212>  DNA
<213>  Rattus norvegicus

<400>  14
agaatgtggt atgatggaga cacagtg                                         27


<210>  15
<211>  39
<212>  DNA
<213>  Rattus norvegicus

<400>  15
gatttcggat actttgatgg tagttccccc tttgattac                            39


<210>  16
<211>  592
<212>  DNA
<213>  Rattus norvegicus

<400>  16
gaggtaaagc tggaggagtc aggacctggt ctggtgcagc cctcagagac cctgtccctc     60

acctgcactg tctctgggtt ctcactaacc acctatagtg taagttgggt tcgccagcct    120

tcaggaaaag gtcctgagtg gatgggaaga atgtggtatg atggagacac agtgtataat    180

tcagctctca aatcccgact gagcatcagc agggacacct ccaagaacca agttttctta    240

aaaatgaaca gtctggaaac tgatgaaaca ggcacttact actgtaccag agatttcgga    300

tactttgatg gtagttcccc ctttgattac tggggccaag gagtcatggt cacagtctcc    360

tcagctgaaa caacagcccc atctgtctat ccactggctc ctggaactgc tctcaaaagt    420

aactccatgg tgaccctggg atgcctggtc aagatcttgc tgaaaaactc gagccatccg    480

gaagatctgg cggccgctct ccctatagtg agtcgtatta cgccggatgg atatggtgtt    540

caggcacaag tgttaaagca gttgatttta ttcactatga gaaaaaaaca at            592


<210>  17
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Arg Arg Ser Leu His Ala Ala Ala Val Leu Leu Leu Val Ile 
1               5                   10                  15      


Leu Lys Glu Gln Pro Ser Ser Pro Ala Pro Val Asn Gly Ser Lys Trp 
            20                  25                  30          


Thr Tyr Phe Gly Pro Asp Gly Glu Asn Ser Trp Ser Lys Lys Tyr Pro 
        35                  40                  45              


Ser Cys Gly Gly Leu Leu Gln Ser Pro Ile Asp Leu His Ser Asp Ile 
    50                  55                  60                  


Leu Gln Tyr Asp Ala Ser Leu Thr Pro Leu Glu Phe Gln Gly Tyr Asn 
65                  70                  75                  80  


Leu Ser Ala Asn Lys Gln Phe Leu Leu Thr Asn Asn Gly His Ser Val 
                85                  90                  95      


Lys Leu Asn Leu Pro Ser Asp Met His Ile Gln Gly Leu Gln Ser Arg 
            100                 105                 110         


Tyr Ser Ala Thr Gln Leu His Leu His Trp Gly Asn Pro Asn Asp Pro 
        115                 120                 125             


His Gly Ser Glu His Thr Val Ser Gly Gln His Phe Ala Ala Glu Leu 
    130                 135                 140                 


His Ile Val His Tyr Asn Ser Asp Leu Tyr Pro Asp Ala Ser Thr Ala 
145                 150                 155                 160 


Ser Asn Lys Ser Glu Gly Leu Ala Val Leu Ala Val Leu Ile Glu Met 
                165                 170                 175     


Gly Ser Phe Asn Pro Ser Tyr Asp Lys Ile Phe Ser His Leu Gln His 
            180                 185                 190         


Val Lys Tyr Lys Gly Gln Glu Ala Phe Val Pro Gly Phe Asn Ile Glu 
        195                 200                 205             


Glu Leu Leu Pro Glu Arg Thr Ala Glu Tyr Tyr Arg Tyr Arg Gly Ser 
    210                 215                 220                 


Leu Thr Thr Pro Pro Cys Asn Pro Thr Val Leu Trp Thr Val Phe Arg 
225                 230                 235                 240 


Asn Pro Val Gln Ile Ser Gln Glu Gln Leu Leu Ala Leu Glu Thr Ala 
                245                 250                 255     


Leu Tyr Cys Thr His Met Asp Asp Pro Ser Pro Arg Glu Met Ile Asn 
            260                 265                 270         


Asn Phe Arg Gln Val Gln Lys Phe Asp Glu Arg Leu Val Tyr Thr Ser 
        275                 280                 285             


Phe Ser Gln Val Gln Val Cys Thr Ala Ala Gly Leu Ser Leu Gly Ile 
    290                 295                 300                 


Ile Leu Ser Leu Ala Leu Ala Gly Ile Leu Gly Ile Cys Ile Val Val 
305                 310                 315                 320 


Val Val Ser Ile Trp Leu Phe Arg Arg Lys Ser Ile Lys Lys Gly Asp 
                325                 330                 335     


Asn Lys Gly Val Ile Tyr Lys Pro Ala Thr Lys Met Glu Thr Glu Ala 
            340                 345                 350         


His Ala 
        


<210>  18
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  18
atgccccggc gcagcctgca cgcggcggcc gtgctcctgc tggtgatctt aaaggaacag     60

ccttccagcc cggccccagt gaacggttcc aagtggactt attttggtcc tgatggggag    120

aatagctggt ccaagaagta cccgtcgtgt gggggcctgc tgcagtcccc catagacctg    180

cacagtgaca tcctccagta tgacgccagc ctcacgcccc tcgagttcca aggctacaat    240

ctgtctgcca acaagcagtt tctcctgacc aacaatggcc attcagtgaa gctgaacctg    300

ccctcggaca tgcacatcca gggcctccag tctcgctaca gtgccacgca gctgcacctg    360

cactggggga acccgaatga cccgcacggc tctgagcaca ccgtcagcgg acagcacttc    420

gccgccgagc tgcacattgt ccattataac tcagaccttt atcctgacgc cagcactgcc    480

agcaacaagt cagaaggcct cgctgtcctg gctgttctca ttgagatggg ctccttcaat    540

ccgtcctatg acaagatctt cagtcacctt caacatgtaa agtacaaagg ccaggaagca    600

ttcgtcccgg gattcaacat tgaagagctg cttccggaga ggaccgctga atattaccgc    660

taccgggggt ccctgaccac acccccttgc aaccccactg tgctctggac agttttccga    720

aaccccgtgc aaatttccca ggagcagctg ctggctttgg agacagccct gtactgcaca    780

cacatggacg acccttcccc cagagaaatg atcaacaact tccggcaggt ccagaagttc    840

gatgagaggc tggtatacac ctccttctcc caagtgcaag tctgtactgc ggcaggactg    900

agtctgggca tcatcctctc actggccctg gctggcattc ttggcatctg tattgtggtg    960

gtggtgtcca tttggctttt cagaaggaag agtatcaaaa aaggtgataa caagggagtc   1020

atttacaagc cagccaccaa gatggagact gaggcccacg cttga                   1065


