                         SEQUENCE LISTING

<110>  INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL
       MOROY, Tarik
       KHANDANPOUR, Cyrus
       VASSEN, Lothar
       SHARIF-ASKARI, Ehssan
 
<120>  GFI1B MODULATION AND USES THEREOF

<130>  12810.406

<150>  US 61/332,311
<151>  2010-05-07

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  1801
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (152)..(1144)

<400>  1
aaaaaggaga agtatctatt tgtgcaaaga gtcacacagt tgacagagtg gaggccagtc       60

ccgagagagg ctttgcagtt cccacctcgg gaagctccgg cagaacccag gcgagggaca      120

gctccggaca ggtgtggggt gcacactgaa a atg cca cgc tcc ttc ctg gtg         172
                                   Met Pro Arg Ser Phe Leu Val            
                                   1               5                      

aag agc aag aag gct cac acc tac cac cag ccc cgt gtg cag gaa gat        220
Lys Ser Lys Lys Ala His Thr Tyr His Gln Pro Arg Val Gln Glu Asp           
        10                  15                  20                        

gaa ccg ctc tgg cct cct gcc ctt acc ccg gtg ccc aga gac cag gct        268
Glu Pro Leu Trp Pro Pro Ala Leu Thr Pro Val Pro Arg Asp Gln Ala           
    25                  30                  35                            

cca agc aac agc cct gtc ctt agc act cta ttc cca aac cag tgc ctg        316
Pro Ser Asn Ser Pro Val Leu Ser Thr Leu Phe Pro Asn Gln Cys Leu           
40                  45                  50                  55            

gac tgg acc aac ctc aaa cga gag ccg gag ctg gag cag gac cag aac        364
Asp Trp Thr Asn Leu Lys Arg Glu Pro Glu Leu Glu Gln Asp Gln Asn           
                60                  65                  70                

ttg gcc agg atg gcc ccg gca cca gag ggc ccc att gtg ctg tcc cga        412
Leu Ala Arg Met Ala Pro Ala Pro Glu Gly Pro Ile Val Leu Ser Arg           
            75                  80                  85                    

ccc cag gat ggg gac tct cca ctg tcc gac tca ccc cca ttc tac aag        460
Pro Gln Asp Gly Asp Ser Pro Leu Ser Asp Ser Pro Pro Phe Tyr Lys           
        90                  95                  100                       

cct agc ttc tcc tgg gac acc ttg gcc aca acc tat ggc cac agc tac        508
Pro Ser Phe Ser Trp Asp Thr Leu Ala Thr Thr Tyr Gly His Ser Tyr           
    105                 110                 115                           

cgg cag gcc ccc tcc acc atg cag tca gcc ttc ctg gag cac tcc gtc        556
Arg Gln Ala Pro Ser Thr Met Gln Ser Ala Phe Leu Glu His Ser Val           
120                 125                 130                 135           

agc ctg tac ggc agt cct ctt gtg ccc agc act gag ccc gcc ttg gac        604
Ser Leu Tyr Gly Ser Pro Leu Val Pro Ser Thr Glu Pro Ala Leu Asp           
                140                 145                 150               

ttc agc ctc cgc tac tcc cca ggc atg gat gcg tac cac tgt gtg aag        652
Phe Ser Leu Arg Tyr Ser Pro Gly Met Asp Ala Tyr His Cys Val Lys           
            155                 160                 165                   

tgc aac aag gtc ttc tcc acc cct cac ggg ctc gaa gtg cat gtg cga        700
Cys Asn Lys Val Phe Ser Thr Pro His Gly Leu Glu Val His Val Arg           
        170                 175                 180                       

cgc tcc cat agt ggg acc cgg ccc ttc gcc tgt gac atc tgc ggc aaa        748
Arg Ser His Ser Gly Thr Arg Pro Phe Ala Cys Asp Ile Cys Gly Lys           
    185                 190                 195                           

acc ttc ggc cac gct gtg agc ctg gag cag cac acg cac gtc cac tcc        796
Thr Phe Gly His Ala Val Ser Leu Glu Gln His Thr His Val His Ser           
200                 205                 210                 215           

cag gag cgc agc ttc gag tgc cgc atg tgc ggc aag gcc ttc aag cgc        844
Gln Glu Arg Ser Phe Glu Cys Arg Met Cys Gly Lys Ala Phe Lys Arg           
                220                 225                 230               

tcg tcc acg ctg tcc acc cac ctg ctc atc cac tca gac acg cgg ccc        892
Ser Ser Thr Leu Ser Thr His Leu Leu Ile His Ser Asp Thr Arg Pro           
            235                 240                 245                   

tac ccc tgc cag ttc tgc ggc aag cgt ttc cac cag aag tcc gac atg        940
Tyr Pro Cys Gln Phe Cys Gly Lys Arg Phe His Gln Lys Ser Asp Met           
        250                 255                 260                       

aag aag cac acc tac atc cac aca ggt gag aag ccg cac aag tgc cag        988
Lys Lys His Thr Tyr Ile His Thr Gly Glu Lys Pro His Lys Cys Gln           
    265                 270                 275                           

gtg tgc gga aag gcc ttc agc cag agc tcc aac ctc atc acc cac agc       1036
Val Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ile Thr His Ser           
280                 285                 290                 295           

cgc aag cac aca ggc ttc aag ccc ttc agc tgt gag ctg tgc acc aaa       1084
Arg Lys His Thr Gly Phe Lys Pro Phe Ser Cys Glu Leu Cys Thr Lys           
                300                 305                 310               

ggc ttc cag cgc aag gtg gac ctg cgg cgg cac cgc gag agc cag cac       1132
Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg Glu Ser Gln His           
            315                 320                 325                   

aat ctc aag tga ggctgcgccg gctcccagct cctggccagc ctgccctgcg           1184
Asn Leu Lys                                                               
        330                                                               

gtcctgtcac ctggaggcca gcctcacatg cccaaatctc cagtctcctg gaggtgggac     1244

tggacaggag tctaccagct tgttttgaga ctcatgaaat tgctgtgtga ccttgggcaa     1304

gtcacttacc ctgtctggat caacatttct cctgctgcca agtgtgggag cctggctggg     1364

tctttctcag cagaagttgt ttccaggtgt gctcaagtgc cttcctctag cagagcacag     1424

aaagctagaa tacccccagg gagacaggga tgccaagagt agaccagagc tgggacccac     1484

agacagaacc tccacctgcc tgctgcccac tgagctggga cctggtcacc ttggatttta     1544

gccggcctct ttctggctat aacaggcaga gtcggagctg cctcccaccc cagtcagaag     1604

cctggcaccc cctctgcttc ggccagatgt gctggctgac tccgacttcc gaccagcact     1664

cagctggcct ctggggattc tagctccaca accaggccgt gaggctggag aaactggcag     1724

ttattgctgt caaaagcctg ttctctcaac tgctgtcaat aaaattaaag atacagattt     1784

gctgccaaaa aaaaaaa                                                    1801


<210>  2
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Thr Tyr His 
1               5                   10                  15      


Gln Pro Arg Val Gln Glu Asp Glu Pro Leu Trp Pro Pro Ala Leu Thr 
            20                  25                  30          


Pro Val Pro Arg Asp Gln Ala Pro Ser Asn Ser Pro Val Leu Ser Thr 
        35                  40                  45              


Leu Phe Pro Asn Gln Cys Leu Asp Trp Thr Asn Leu Lys Arg Glu Pro 
    50                  55                  60                  


Glu Leu Glu Gln Asp Gln Asn Leu Ala Arg Met Ala Pro Ala Pro Glu 
65                  70                  75                  80  


Gly Pro Ile Val Leu Ser Arg Pro Gln Asp Gly Asp Ser Pro Leu Ser 
                85                  90                  95      


Asp Ser Pro Pro Phe Tyr Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala 
            100                 105                 110         


Thr Thr Tyr Gly His Ser Tyr Arg Gln Ala Pro Ser Thr Met Gln Ser 
        115                 120                 125             


Ala Phe Leu Glu His Ser Val Ser Leu Tyr Gly Ser Pro Leu Val Pro 
    130                 135                 140                 


Ser Thr Glu Pro Ala Leu Asp Phe Ser Leu Arg Tyr Ser Pro Gly Met 
145                 150                 155                 160 


Asp Ala Tyr His Cys Val Lys Cys Asn Lys Val Phe Ser Thr Pro His 
                165                 170                 175     


Gly Leu Glu Val His Val Arg Arg Ser His Ser Gly Thr Arg Pro Phe 
            180                 185                 190         


Ala Cys Asp Ile Cys Gly Lys Thr Phe Gly His Ala Val Ser Leu Glu 
        195                 200                 205             


Gln His Thr His Val His Ser Gln Glu Arg Ser Phe Glu Cys Arg Met 
    210                 215                 220                 


Cys Gly Lys Ala Phe Lys Arg Ser Ser Thr Leu Ser Thr His Leu Leu 
225                 230                 235                 240 


Ile His Ser Asp Thr Arg Pro Tyr Pro Cys Gln Phe Cys Gly Lys Arg 
                245                 250                 255     


Phe His Gln Lys Ser Asp Met Lys Lys His Thr Tyr Ile His Thr Gly 
            260                 265                 270         


Glu Lys Pro His Lys Cys Gln Val Cys Gly Lys Ala Phe Ser Gln Ser 
        275                 280                 285             


Ser Asn Leu Ile Thr His Ser Arg Lys His Thr Gly Phe Lys Pro Phe 
    290                 295                 300                 


Ser Cys Glu Leu Cys Thr Lys Gly Phe Gln Arg Lys Val Asp Leu Arg 
305                 310                 315                 320 


Arg His Arg Glu Ser Gln His Asn Leu Lys 
                325                 330 


<210>  3
<211>  1663
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (152)..(1006)

<400>  3
aaaaaggaga agtatctatt tgtgcaaaga gtcacacagt tgacagagtg gaggccagtc       60

ccgagagagg ctttgcagtt cccacctcgg gaagctccgg cagaacccag gcgagggaca      120

gctccggaca ggtgtggggt gcacactgaa a atg cca cgc tcc ttc ctg gtg         172
                                   Met Pro Arg Ser Phe Leu Val            
                                   1               5                      

aag agc aag aag gct cac acc tac cac cag ccc cgt gtg cag gaa gat        220
Lys Ser Lys Lys Ala His Thr Tyr His Gln Pro Arg Val Gln Glu Asp           
        10                  15                  20                        

gaa ccg ctc tgg cct cct gcc ctt acc ccg gtg ccc aga gac cag gct        268
Glu Pro Leu Trp Pro Pro Ala Leu Thr Pro Val Pro Arg Asp Gln Ala           
    25                  30                  35                            

cca agc aac agc cct gtc ctt agc act cta ttc cca aac cag tgc ctg        316
Pro Ser Asn Ser Pro Val Leu Ser Thr Leu Phe Pro Asn Gln Cys Leu           
40                  45                  50                  55            

gac tgg acc aac ctc aaa cga gag ccg gag ctg gag cag gac cag aac        364
Asp Trp Thr Asn Leu Lys Arg Glu Pro Glu Leu Glu Gln Asp Gln Asn           
                60                  65                  70                

ttg gcc agg atg gcc ccg gca cca gag ggc ccc att gtg ctg tcc cga        412
Leu Ala Arg Met Ala Pro Ala Pro Glu Gly Pro Ile Val Leu Ser Arg           
            75                  80                  85                    

ccc cag gat ggg gac tct cca ctg tcc gac tca ccc cca ttc tac aag        460
Pro Gln Asp Gly Asp Ser Pro Leu Ser Asp Ser Pro Pro Phe Tyr Lys           
        90                  95                  100                       

cct agc ttc tcc tgg gac acc ttg gcc aca acc tat ggc cac agc tac        508
Pro Ser Phe Ser Trp Asp Thr Leu Ala Thr Thr Tyr Gly His Ser Tyr           
    105                 110                 115                           

cgg cag gcc ccc tcc acc atg cag tca gcc ttc ctg gag cac tcc gtc        556
Arg Gln Ala Pro Ser Thr Met Gln Ser Ala Phe Leu Glu His Ser Val           
120                 125                 130                 135           

agc ctg tac ggc agt cct ctt gtg ccc agc act gag ccc gcc ttg gac        604
Ser Leu Tyr Gly Ser Pro Leu Val Pro Ser Thr Glu Pro Ala Leu Asp           
                140                 145                 150               

ttc agc ctc cgc tac tcc cca ggc atg gat gcg tac cac tgt gtg aag        652
Phe Ser Leu Arg Tyr Ser Pro Gly Met Asp Ala Tyr His Cys Val Lys           
            155                 160                 165                   

tgc aac aag gag cgc agc ttc gag tgc cgc atg tgc ggc aag gcc ttc        700
Cys Asn Lys Glu Arg Ser Phe Glu Cys Arg Met Cys Gly Lys Ala Phe           
        170                 175                 180                       

aag cgc tcg tcc acg ctg tcc acc cac ctg ctc atc cac tca gac acg        748
Lys Arg Ser Ser Thr Leu Ser Thr His Leu Leu Ile His Ser Asp Thr           
    185                 190                 195                           

cgg ccc tac ccc tgc cag ttc tgc ggc aag cgt ttc cac cag aag tcc        796
Arg Pro Tyr Pro Cys Gln Phe Cys Gly Lys Arg Phe His Gln Lys Ser           
200                 205                 210                 215           

gac atg aag aag cac acc tac atc cac aca ggt gag aag ccg cac aag        844
Asp Met Lys Lys His Thr Tyr Ile His Thr Gly Glu Lys Pro His Lys           
                220                 225                 230               

tgc cag gtg tgc gga aag gcc ttc agc cag agc tcc aac ctc atc acc        892
Cys Gln Val Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ile Thr           
            235                 240                 245                   

cac agc cgc aag cac aca ggc ttc aag ccc ttc agc tgt gag ctg tgc        940
His Ser Arg Lys His Thr Gly Phe Lys Pro Phe Ser Cys Glu Leu Cys           
        250                 255                 260                       

acc aaa ggc ttc cag cgc aag gtg gac ctg cgg cgg cac cgc gag agc        988
Thr Lys Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg Glu Ser           
    265                 270                 275                           

cag cac aat ctc aag tga ggctgcgccg gctcccagct cctggccagc              1036
Gln His Asn Leu Lys                                                       
280                                                                       

ctgccctgcg gtcctgtcac ctggaggcca gcctcacatg cccaaatctc cagtctcctg     1096

gaggtgggac tggacaggag tctaccagct tgttttgaga ctcatgaaat tgctgtgtga     1156

ccttgggcaa gtcacttacc ctgtctggat caacatttct cctgctgcca agtgtgggag     1216

cctggctggg tctttctcag cagaagttgt ttccaggtgt gctcaagtgc cttcctctag     1276

cagagcacag aaagctagaa tacccccagg gagacaggga tgccaagagt agaccagagc     1336

tgggacccac agacagaacc tccacctgcc tgctgcccac tgagctggga cctggtcacc     1396

ttggatttta gccggcctct ttctggctat aacaggcaga gtcggagctg cctcccaccc     1456

cagtcagaag cctggcaccc cctctgcttc ggccagatgt gctggctgac tccgacttcc     1516

gaccagcact cagctggcct ctggggattc tagctccaca accaggccgt gaggctggag     1576

aaactggcag ttattgctgt caaaagcctg ttctctcaac tgctgtcaat aaaattaaag     1636

atacagattt gctgccaaaa aaaaaaa                                         1663


<210>  4
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Thr Tyr His 
1               5                   10                  15      


Gln Pro Arg Val Gln Glu Asp Glu Pro Leu Trp Pro Pro Ala Leu Thr 
            20                  25                  30          


Pro Val Pro Arg Asp Gln Ala Pro Ser Asn Ser Pro Val Leu Ser Thr 
        35                  40                  45              


Leu Phe Pro Asn Gln Cys Leu Asp Trp Thr Asn Leu Lys Arg Glu Pro 
    50                  55                  60                  


Glu Leu Glu Gln Asp Gln Asn Leu Ala Arg Met Ala Pro Ala Pro Glu 
65                  70                  75                  80  


Gly Pro Ile Val Leu Ser Arg Pro Gln Asp Gly Asp Ser Pro Leu Ser 
                85                  90                  95      


Asp Ser Pro Pro Phe Tyr Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala 
            100                 105                 110         


Thr Thr Tyr Gly His Ser Tyr Arg Gln Ala Pro Ser Thr Met Gln Ser 
        115                 120                 125             


Ala Phe Leu Glu His Ser Val Ser Leu Tyr Gly Ser Pro Leu Val Pro 
    130                 135                 140                 


Ser Thr Glu Pro Ala Leu Asp Phe Ser Leu Arg Tyr Ser Pro Gly Met 
145                 150                 155                 160 


Asp Ala Tyr His Cys Val Lys Cys Asn Lys Glu Arg Ser Phe Glu Cys 
                165                 170                 175     


Arg Met Cys Gly Lys Ala Phe Lys Arg Ser Ser Thr Leu Ser Thr His 
            180                 185                 190         


Leu Leu Ile His Ser Asp Thr Arg Pro Tyr Pro Cys Gln Phe Cys Gly 
        195                 200                 205             


Lys Arg Phe His Gln Lys Ser Asp Met Lys Lys His Thr Tyr Ile His 
    210                 215                 220                 


Thr Gly Glu Lys Pro His Lys Cys Gln Val Cys Gly Lys Ala Phe Ser 
225                 230                 235                 240 


Gln Ser Ser Asn Leu Ile Thr His Ser Arg Lys His Thr Gly Phe Lys 
                245                 250                 255     


Pro Phe Ser Cys Glu Leu Cys Thr Lys Gly Phe Gln Arg Lys Val Asp 
            260                 265                 270         


Leu Arg Arg His Arg Glu Ser Gln His Asn Leu Lys 
        275                 280                 


<210>  5
<211>  1724
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (156)..(1148)

<400>  5
cacagaaacg aaaaggagaa gtgtctgtct gtgcagagac tcataacgtt gaccgagccg       60

agagcagtcc ccagggacag tgtggaggtt cgtggctctc gggcagaact cagaagaggg      120

acagctccct gacggtgtgg cgtgcacgca gaaaa atg cca cgg tcc ttt cta         173
                                       Met Pro Arg Ser Phe Leu            
                                       1               5                  

gtg aag agt aag aag gca cac act tac cac cag ccc cgg gca cag ggt        221
Val Lys Ser Lys Lys Ala His Thr Tyr His Gln Pro Arg Ala Gln Gly           
            10                  15                  20                    

gat gag ctg gtc tgg cct cct gct gta att cct gtg gca aaa gag cat        269
Asp Glu Leu Val Trp Pro Pro Ala Val Ile Pro Val Ala Lys Glu His           
        25                  30                  35                        

agc cag agt gcc agc cct ctt ctc agc aca ccg ctt cca agc cag acc        317
Ser Gln Ser Ala Ser Pro Leu Leu Ser Thr Pro Leu Pro Ser Gln Thr           
    40                  45                  50                            

ttg gac tgg aac aca atc aaa cag gag cgg gag atg ttg ctg aac cag        365
Leu Asp Trp Asn Thr Ile Lys Gln Glu Arg Glu Met Leu Leu Asn Gln           
55                  60                  65                  70            

agc ctt ccc aag atg gcc tca gcc cca gag ggg cct ctc gtg aca ccc        413
Ser Leu Pro Lys Met Ala Ser Ala Pro Glu Gly Pro Leu Val Thr Pro           
                75                  80                  85                

caa ccc cag gat ggg gaa tca cca ctc tct gag tca ccc cct ttc tac        461
Gln Pro Gln Asp Gly Glu Ser Pro Leu Ser Glu Ser Pro Pro Phe Tyr           
            90                  95                  100                   

aag ccc agc ttc tcc tgg gat acc ttg gcc tcc tcc tac agc cac agc        509
Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala Ser Ser Tyr Ser His Ser           
        105                 110                 115                       

tac aca cag acc ccc tcc acc atg cag tcc gcc ttc ctg gag cgc tcc        557
Tyr Thr Gln Thr Pro Ser Thr Met Gln Ser Ala Phe Leu Glu Arg Ser           
    120                 125                 130                           

gtg agg ctg tac ggc agc ccc ctc gtg ccc agc aca gag tct ccc ttg        605
Val Arg Leu Tyr Gly Ser Pro Leu Val Pro Ser Thr Glu Ser Pro Leu           
135                 140                 145                 150           

gac ttc cgc ctc cgc tac tct cca ggc atg gac act tac cac tgt gtc        653
Asp Phe Arg Leu Arg Tyr Ser Pro Gly Met Asp Thr Tyr His Cys Val           
                155                 160                 165               

aag tgc aac aag gtg ttc tcc acc cct cat ggg cta gaa gtg cat gtc        701
Lys Cys Asn Lys Val Phe Ser Thr Pro His Gly Leu Glu Val His Val           
            170                 175                 180                   

cgc cgc tct cac agc gga acc cgg ccc ttt gcc tgt gat gtc tgt ggc        749
Arg Arg Ser His Ser Gly Thr Arg Pro Phe Ala Cys Asp Val Cys Gly           
        185                 190                 195                       

aaa acc ttt ggc cac gct gtg agc ttg gag cag cat act cac gtc cac        797
Lys Thr Phe Gly His Ala Val Ser Leu Glu Gln His Thr His Val His           
    200                 205                 210                           

tca cag gag cga agc ttc gag tgc cgg atg tgt ggc aaa gcc ttc aag        845
Ser Gln Glu Arg Ser Phe Glu Cys Arg Met Cys Gly Lys Ala Phe Lys           
215                 220                 225                 230           

cgt tca tcc acc ctg tcc acc cac ctg ctc atc cac tcg gac act cgg        893
Arg Ser Ser Thr Leu Ser Thr His Leu Leu Ile His Ser Asp Thr Arg           
                235                 240                 245               

ccc tac ccc tgc cag ttc tgt ggg aag cgc ttc cac cag aag tcg gac        941
Pro Tyr Pro Cys Gln Phe Cys Gly Lys Arg Phe His Gln Lys Ser Asp           
            250                 255                 260                   

atg aag aaa cac acc tac atc cac aca ggt gag aag ccc cac aag tgc        989
Met Lys Lys His Thr Tyr Ile His Thr Gly Glu Lys Pro His Lys Cys           
        265                 270                 275                       

cag gtg tgt ggg aaa gcc ttc agc cag agc tcc aac ctc atc acc cac       1037
Gln Val Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ile Thr His           
    280                 285                 290                           

agc cgc aag cac aca ggc ttc aag ccg ttc agc tgt gag ctg tgc acc       1085
Ser Arg Lys His Thr Gly Phe Lys Pro Phe Ser Cys Glu Leu Cys Thr           
295                 300                 305                 310           

aag ggc ttc cag cgc aag gtg gac ctg cga cgt cac cgt gag agt caa       1133
Lys Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg Glu Ser Gln           
                315                 320                 325               

cac aat ctc aag tga gacggttggc cgcctgcttt agtgtgtctc gcctgaaggc       1188
His Asn Leu Lys                                                           
            330                                                           

cagcctctcc tttccaatcc tgatcccagt cctcctggaa gcagcattgc ccatgagcct     1248

ctctgcttct tttgagactg gatgacctca accaagccac actcctcctc tgaccacagc     1308

tgatgtggga gtcagttcgg gcctttctga actgaggcag tcacagacat gctctggtct     1368

cattcaatgc cagagcacag acagctacaa agccctcgtg gacatggcaa aaccaggcaa     1428

gagccaggat ccacagagaa accctcttgc ttgcttctct gggtctagtg actgaatttt     1488

tagggattct ctttttggct gccacagtca gagttgtccc ctggcctaga ggtctggcgc     1548

ccctctgctt cggccagatg tgctctctgt cccccacctc tcaccacatc catccgccca     1608

ctgggagtca ggctcctgag gtgagccacg aggctatgaa atcagccatg atagtagaag     1668

cctgctccta tcagttgatg taaatgtaaa taaaggtggg tttatttaca tgtgaa         1724


<210>  6
<211>  330
<212>  PRT
<213>  Mus musculus

<400>  6

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Thr Tyr His 
1               5                   10                  15      


Gln Pro Arg Ala Gln Gly Asp Glu Leu Val Trp Pro Pro Ala Val Ile 
            20                  25                  30          


Pro Val Ala Lys Glu His Ser Gln Ser Ala Ser Pro Leu Leu Ser Thr 
        35                  40                  45              


Pro Leu Pro Ser Gln Thr Leu Asp Trp Asn Thr Ile Lys Gln Glu Arg 
    50                  55                  60                  


Glu Met Leu Leu Asn Gln Ser Leu Pro Lys Met Ala Ser Ala Pro Glu 
65                  70                  75                  80  


Gly Pro Leu Val Thr Pro Gln Pro Gln Asp Gly Glu Ser Pro Leu Ser 
                85                  90                  95      


Glu Ser Pro Pro Phe Tyr Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala 
            100                 105                 110         


Ser Ser Tyr Ser His Ser Tyr Thr Gln Thr Pro Ser Thr Met Gln Ser 
        115                 120                 125             


Ala Phe Leu Glu Arg Ser Val Arg Leu Tyr Gly Ser Pro Leu Val Pro 
    130                 135                 140                 


Ser Thr Glu Ser Pro Leu Asp Phe Arg Leu Arg Tyr Ser Pro Gly Met 
145                 150                 155                 160 


Asp Thr Tyr His Cys Val Lys Cys Asn Lys Val Phe Ser Thr Pro His 
                165                 170                 175     


Gly Leu Glu Val His Val Arg Arg Ser His Ser Gly Thr Arg Pro Phe 
            180                 185                 190         


Ala Cys Asp Val Cys Gly Lys Thr Phe Gly His Ala Val Ser Leu Glu 
        195                 200                 205             


Gln His Thr His Val His Ser Gln Glu Arg Ser Phe Glu Cys Arg Met 
    210                 215                 220                 


Cys Gly Lys Ala Phe Lys Arg Ser Ser Thr Leu Ser Thr His Leu Leu 
225                 230                 235                 240 


Ile His Ser Asp Thr Arg Pro Tyr Pro Cys Gln Phe Cys Gly Lys Arg 
                245                 250                 255     


Phe His Gln Lys Ser Asp Met Lys Lys His Thr Tyr Ile His Thr Gly 
            260                 265                 270         


Glu Lys Pro His Lys Cys Gln Val Cys Gly Lys Ala Phe Ser Gln Ser 
        275                 280                 285             


Ser Asn Leu Ile Thr His Ser Arg Lys His Thr Gly Phe Lys Pro Phe 
    290                 295                 300                 


Ser Cys Glu Leu Cys Thr Lys Gly Phe Gln Arg Lys Val Asp Leu Arg 
305                 310                 315                 320 


Arg His Arg Glu Ser Gln His Asn Leu Lys 
                325                 330 


<210>  7
<211>  1823
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (156)..(1247)

<400>  7
cacagaaacg aaaaggagaa gtgtctgtct gtgcagagac tcataacgtt gaccgagccg       60

agagcagtcc ccagggacag tgtggaggtt cgtggctctc gggcagaact cagaagaggg      120

acagctccct gacggtgtgg cgtgcacgca gaaaa atg cca cgg tcc ttt cta         173
                                       Met Pro Arg Ser Phe Leu            
                                       1               5                  

gtg aag agt aag aag gca cac act tac cac cag ccc cgg gca cag ggt        221
Val Lys Ser Lys Lys Ala His Thr Tyr His Gln Pro Arg Ala Gln Gly           
            10                  15                  20                    

gat gag ctg gtc tgg cct cct gct gta att cct gtg gca aaa gag cat        269
Asp Glu Leu Val Trp Pro Pro Ala Val Ile Pro Val Ala Lys Glu His           
        25                  30                  35                        

agc cag agt gcc agc cct ctt ctc agc aca ccg ctt cca agc cag acc        317
Ser Gln Ser Ala Ser Pro Leu Leu Ser Thr Pro Leu Pro Ser Gln Thr           
    40                  45                  50                            

ttg gac tgg aac aca atc aaa cag gag cgg gag atg ttg ctg aac cag        365
Leu Asp Trp Asn Thr Ile Lys Gln Glu Arg Glu Met Leu Leu Asn Gln           
55                  60                  65                  70            

agc ctt ccc aag atg gcc tca gcc cca gag ggg cct ctc gtg aca ccc        413
Ser Leu Pro Lys Met Ala Ser Ala Pro Glu Gly Pro Leu Val Thr Pro           
                75                  80                  85                

caa ccc cag gat ggg gaa tca cca ctc tct gag tca ccc cct ttc tac        461
Gln Pro Gln Asp Gly Glu Ser Pro Leu Ser Glu Ser Pro Pro Phe Tyr           
            90                  95                  100                   

aag ccc agc ttc tcc tgg gat acc ttg gcc tcc tcc tac agc cac agc        509
Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala Ser Ser Tyr Ser His Ser           
        105                 110                 115                       

tac aca cag acc ccc tcc acc atg cag tcc gcc ttc ctg gag cgc tcc        557
Tyr Thr Gln Thr Pro Ser Thr Met Gln Ser Ala Phe Leu Glu Arg Ser           
    120                 125                 130                           

gtg agg ctg tac ggc agc ccc ctc gtg ccc agc aca gag tct ccc ttg        605
Val Arg Leu Tyr Gly Ser Pro Leu Val Pro Ser Thr Glu Ser Pro Leu           
135                 140                 145                 150           

gac ttc cgc ctc cgc tac tct cca ggc atg gac act tac cac tgt gtc        653
Asp Phe Arg Leu Arg Tyr Ser Pro Gly Met Asp Thr Tyr His Cys Val           
                155                 160                 165               

aag tgc aac aag gtg ttc tcc acc cct cat ggg cta gaa gtg cat gtc        701
Lys Cys Asn Lys Val Phe Ser Thr Pro His Gly Leu Glu Val His Val           
            170                 175                 180                   

cgc cgc tct cac agc gga acc cgg ccc ttt gcc tgt gat gtc tgt ggc        749
Arg Arg Ser His Ser Gly Thr Arg Pro Phe Ala Cys Asp Val Cys Gly           
        185                 190                 195                       

aaa acc ttt ggc cac gct gtg agc ttg gag cag cat act cac gtc cac        797
Lys Thr Phe Gly His Ala Val Ser Leu Glu Gln His Thr His Val His           
    200                 205                 210                           

tca cag ggc gtc cca gcc ggg tcc agt cct acg ccc acc ttg gct gtc        845
Ser Gln Gly Val Pro Ala Gly Ser Ser Pro Thr Pro Thr Leu Ala Val           
215                 220                 225                 230           

ccg ggc ctt gag gcc cca cct gca cct gac ccc cca ggg cct cgt ttc        893
Pro Gly Leu Glu Ala Pro Pro Ala Pro Asp Pro Pro Gly Pro Arg Phe           
                235                 240                 245               

ctc cgg cag gag cga agc ttc gag tgc cgg atg tgt ggc aaa gcc ttc        941
Leu Arg Gln Glu Arg Ser Phe Glu Cys Arg Met Cys Gly Lys Ala Phe           
            250                 255                 260                   

aag cgt tca tcc acc ctg tcc acc cac ctg ctc atc cac tcg gac act        989
Lys Arg Ser Ser Thr Leu Ser Thr His Leu Leu Ile His Ser Asp Thr           
        265                 270                 275                       

cgg ccc tac ccc tgc cag ttc tgt ggg aag cgc ttc cac cag aag tcg       1037
Arg Pro Tyr Pro Cys Gln Phe Cys Gly Lys Arg Phe His Gln Lys Ser           
    280                 285                 290                           

gac atg aag aaa cac acc tac atc cac aca ggt gag aag ccc cac aag       1085
Asp Met Lys Lys His Thr Tyr Ile His Thr Gly Glu Lys Pro His Lys           
295                 300                 305                 310           

tgc cag gtg tgt ggg aaa gcc ttc agc cag agc tcc aac ctc atc acc       1133
Cys Gln Val Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ile Thr           
                315                 320                 325               

cac agc cgc aag cac aca ggc ttc aag ccg ttc agc tgt gag ctg tgc       1181
His Ser Arg Lys His Thr Gly Phe Lys Pro Phe Ser Cys Glu Leu Cys           
            330                 335                 340                   

acc aag ggc ttc cag cgc aag gtg gac ctg cga cgt cac cgt gag agt       1229
Thr Lys Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg Glu Ser           
        345                 350                 355                       

caa cac aat ctc aag tga gacggttggc cgcctgcttt agtgtgtctc              1277
Gln His Asn Leu Lys                                                       
    360                                                                   

gcctgaaggc cagcctctcc tttccaatcc tgatcccagt cctcctggaa gcagcattgc     1337

ccatgagcct ctctgcttct tttgagactg gatgacctca accaagccac actcctcctc     1397

tgaccacagc tgatgtggga gtcagttcgg gcctttctga actgaggcag tcacagacat     1457

gctctggtct cattcaatgc cagagcacag acagctacaa agccctcgtg gacatggcaa     1517

aaccaggcaa gagccaggat ccacagagaa accctcttgc ttgcttctct gggtctagtg     1577

actgaatttt tagggattct ctttttggct gccacagtca gagttgtccc ctggcctaga     1637

ggtctggcgc ccctctgctt cggccagatg tgctctctgt cccccacctc tcaccacatc     1697

catccgccca ctgggagtca ggctcctgag gtgagccacg aggctatgaa atcagccatg     1757

atagtagaag cctgctccta tcagttgatg taaatgtaaa taaaggtggg tttatttaca     1817

tgtgaa                                                                1823


<210>  8
<211>  363
<212>  PRT
<213>  Mus musculus

<400>  8

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Thr Tyr His 
1               5                   10                  15      


Gln Pro Arg Ala Gln Gly Asp Glu Leu Val Trp Pro Pro Ala Val Ile 
            20                  25                  30          


Pro Val Ala Lys Glu His Ser Gln Ser Ala Ser Pro Leu Leu Ser Thr 
        35                  40                  45              


Pro Leu Pro Ser Gln Thr Leu Asp Trp Asn Thr Ile Lys Gln Glu Arg 
    50                  55                  60                  


Glu Met Leu Leu Asn Gln Ser Leu Pro Lys Met Ala Ser Ala Pro Glu 
65                  70                  75                  80  


Gly Pro Leu Val Thr Pro Gln Pro Gln Asp Gly Glu Ser Pro Leu Ser 
                85                  90                  95      


Glu Ser Pro Pro Phe Tyr Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala 
            100                 105                 110         


Ser Ser Tyr Ser His Ser Tyr Thr Gln Thr Pro Ser Thr Met Gln Ser 
        115                 120                 125             


Ala Phe Leu Glu Arg Ser Val Arg Leu Tyr Gly Ser Pro Leu Val Pro 
    130                 135                 140                 


Ser Thr Glu Ser Pro Leu Asp Phe Arg Leu Arg Tyr Ser Pro Gly Met 
145                 150                 155                 160 


Asp Thr Tyr His Cys Val Lys Cys Asn Lys Val Phe Ser Thr Pro His 
                165                 170                 175     


Gly Leu Glu Val His Val Arg Arg Ser His Ser Gly Thr Arg Pro Phe 
            180                 185                 190         


Ala Cys Asp Val Cys Gly Lys Thr Phe Gly His Ala Val Ser Leu Glu 
        195                 200                 205             


Gln His Thr His Val His Ser Gln Gly Val Pro Ala Gly Ser Ser Pro 
    210                 215                 220                 


Thr Pro Thr Leu Ala Val Pro Gly Leu Glu Ala Pro Pro Ala Pro Asp 
225                 230                 235                 240 


Pro Pro Gly Pro Arg Phe Leu Arg Gln Glu Arg Ser Phe Glu Cys Arg 
                245                 250                 255     


Met Cys Gly Lys Ala Phe Lys Arg Ser Ser Thr Leu Ser Thr His Leu 
            260                 265                 270         


Leu Ile His Ser Asp Thr Arg Pro Tyr Pro Cys Gln Phe Cys Gly Lys 
        275                 280                 285             


Arg Phe His Gln Lys Ser Asp Met Lys Lys His Thr Tyr Ile His Thr 
    290                 295                 300                 


Gly Glu Lys Pro His Lys Cys Gln Val Cys Gly Lys Ala Phe Ser Gln 
305                 310                 315                 320 


Ser Ser Asn Leu Ile Thr His Ser Arg Lys His Thr Gly Phe Lys Pro 
                325                 330                 335     


Phe Ser Cys Glu Leu Cys Thr Lys Gly Phe Gln Arg Lys Val Asp Leu 
            340                 345                 350         


Arg Arg His Arg Glu Ser Gln His Asn Leu Lys 
        355                 360             


<210>  9
<211>  15084
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gfi1b conditional knock-out plasmid construct

<400>  9
gagctcagtg ggagacagaa tcctgttggt taagagtgat ctgtactggc ccaggatcca       60

agagctttaa acacaggggc ccctctaatg cctcagcgag aaagtgtgtg atggtggaat      120

ctaggagagg agaagcaaga ggaagaaggg agaaaaagag gagagaggag gaggagagga      180

aggagagggg gaagaaaagg aagatggatg gggaaagaag agaaaagggg aagaggggga      240

agggagggaa agaaggaagg gaaagaaata aaatctaaag caaggatgag ggactgtaag      300

tcaatgctag acttttacat tttaataagt tagccactct ctttcaccca aatgctactg      360

aaagtttctg gagaaatttc cagtgggtta gaagcttctg tgaagttttg ataagcaaat      420

gtggctgcac tttcgcgctc tggtcattgg ctgacgctgc agccgccaga ttttgacaca      480

aataatcaga ttgaaaatca gggaggggaa cagaaggggg gcgggaaaca cagaaacgaa      540

aaggagaagt gtctgtctgt gcagagactc ataacgttga ccgagccgag agcagtcccc      600

agggacagtg tggaggttcg tggctctcgg gcagaactca gaagagggac agctccctga      660

cggtgagtgc tgccagaccc gtgctggctg ggctccgctg aaaagttcgt cctgggtgcc      720

caaggcaggg agggtgtctg cttcccttta aggtgagagg aagaatactg tggtagtctc      780

tcttctggat gcagtgctca tcaccagggg agagaagaag gaaggaacat ggaccagtcc      840

cgatacccca agatagcgca aacaccgagc tttcctcctg cgaattctgt gaaacttcat      900

tgtagggggc taggcttcac ccagatacac aaagtcaatc ccccccttca cacacacaca      960

cacacacaca cacacacaca cacacacaca cacacacaga gcacttttct aggggcacca     1020

gaggagccca aattggtgtc cccctgggct agagctgccc tgtgccagga tctcagaagg     1080

gattggtagc tctgatgacc ctctcaaaag ttcctggaag caccggggag gggagtcaga     1140

caccctttcc ttgggaattt actgaaggga aatgacaagg tgaggcagac cacaggatga     1200

tggaggggag gcactgccaa aggctcttgg ctccttgagc atctgtagct cttctcacct     1260

agaggaaaag gtgagtttga gttgtggttt tcttagaaaa cagggctcat tgcagagatg     1320

cccacggatg gatgctgtgg tctgtgactg ggtcctggga aagccagcat ttttatgaga     1380

ctactgtggg gaaagccaag tcaccctagc tgtggagttg gacagcctgg gtactggcag     1440

agctgtgcct atccacctgt gctcttccaa gtctgcaaag ccctccatca ggagaggggt     1500

aacattttga tttgggggtc aacctgtaga aagtccctcg gggagttggg tggctctgga     1560

tgatttaggt ctgatggaat cgccccagtg gtgctcacca ttcccagaac ttcaaaaagg     1620

tgggtgcagg tcccaggtct cccttcaccg gggcacagag cctgctcgca ggcagaaata     1680

gcaggagact cctccgtctg aaggcgtttg cattgaatcc tttctggtgt cagtcccagc     1740

cggccgtggg gagtgtgggg gctgtttgcc cagttttgtt tccattgtgg taaaacaagt     1800

ccatagaact gacctttttt tttttttttt tttttgcttt tgagttacgt ggtgttcttc     1860

ggcatgggca tgggacgtac actctggtcc cgactccttc cttctctcct ttctcactac     1920

atagtaaaaa aacaacaaca acaacaacaa aaaaaaaatc aaccaaacaa caaacaaatg     1980

aacaaacaaa aacttaattt ctgatccttc tgcctccacc ctctgtcact gtgtcctgag     2040

ctacatcccc agtcctttct tcttttcttt cattattttt ttaatctctc ctttctgttt     2100

ttttttttgg ggggggggtc gagacagggt ttctctgtgt agccctggat gtcctggaac     2160

tcactttgta gaccaggctg gcctcgaact cagaaatcca cctgcctctg cctccctggt     2220

gctgggatta aaggcgtgcg ccaccatgcc tggctccttt ctgtttttaa tttaagatta     2280

ctatcactaa ctaggcatgg aggcgcatgc ctttaatcct agcatttggg agccagaggc     2340

aggtagattt ctgtgagttt gaggccagtc tgatctacat agagagttcc agaacagcca     2400

gtgtctcaaa agaactacaa aagtattgtt gttgttgttg tttgtttttc gtgtaagaga     2460

gatgtggggc tcacatgcca cagcacgcat gtggaggtca gagaactact ttacagtgtc     2520

tgctctcttt ctgccccgtg ggttctggga actgaacgta agtcatcagg cctgcatggc     2580

aagtgtctca cccactgaga tagctcactg acccacttta ttccattttt gaccaggctg     2640

acccagaact catgggctca agcaatcctg acttcctcga acttatccag gactcaagat     2700

gcttggccct aggccgagca catcttaaga gctgttcatt aactatcgag aagattcatc     2760

ttgttcaacc gtgtgttaat ccccaaggcc gtgtcctttt gtgaaactga gaccccatcc     2820

ttattaacca ataactgttc tcctgcaccc agcccctgct agcctcaaat ctagtcctgt     2880

gagtttgcct attctgcaca actagatatt tgtccttctg tggctagctt atcttgctcc     2940

ctatgtttgt ggggtgcatc gtgccacaca tgctgaagtt tccttcagtt ggatgtctgg     3000

atcacattgt gtgctttggc ctggctatat tccttgctca tccatcctgc ctagatggac     3060

acttgtacct ctcagctctt gcagatggtg ctgctgtgaa cgtagacggt caggggctct     3120

gaactctgtg ctttggtgta tgcctgaaag tcatcgctca ctttatttat atatttattt     3180

ggtggtaatg gctactgaac cctgggcttc ccacctgcca ggcactgact ttaggttccc     3240

taaggtgacc caggctcctg gccgtgactc catgacgtgg ccctgcagct tgtttgttgc     3300

ctccctccct tctgtcttga cacataagga agtccaaagg gtcccctgta gctgaccctg     3360

agaatcagcc cagtcttgcc caaccctcct gaaaagggaa cctaactgac cagtgtctca     3420

gacaaggtag gtcagtcctt agctgaaggt caacagattg tacatgggat tttagagtaa     3480

aggggaagtt tagaaatctc ttagcccaac ggtctcctct gagagatagg aaaaccaaac     3540

ccaggttagt ggtgcacgcg gtcacagaat cagactcatc tcccgtgggt tgcacaaggt     3600

tcctggagtc aggaaatcct gatgaagcca ctgtgctcaa aacctgggtg tgcaggatgt     3660

tccagccttc caggcagctc tggctgcagt tccagcctgg gtccattgac taagtctgga     3720

tagaaggttt atgaaggatg atgacaaggg gcacaagggg cctcttgctg gagcccagat     3780

accatcactg tctctgtttt atgaagaaat ccgagtgcct ttcacaatct ctgccctgag     3840

ctctttctca gaatggttcg tgtgaatcaa aaccgagtgg ttgttaatta actacattat     3900

aggtaattgg ttcccctttc tttctttctt aactcagcta acaagggcca aaagcaaact     3960

ctctggatac tcttggctac tgctgtaggc ttgggggagg gggtgtgtgt ctgaccaagg     4020

ctcagctgtc ctgatggaaa agaatgctct agaagggaaa ggatagagct aaggcaaccc     4080

agttggagga agcaagacgc ccaggacctc ttgcttccca cgtaagcata aagcattcag     4140

taagtgctca tgaatgtagg atggaggtcc tggtcctgtg ttgctctggg tttgggtcag     4200

ctgacctagg gtcacctcta actggaccac gggcaaaact gcctttaagg aagtctgttc     4260

caggtgaagc tagttgggac tctgtgtggg gtctttgggg atcagaggaa taagaccttt     4320

tgtcctcgcg cccagctgct tttgatacaa tcatctatac cagaggccgc tgtgaggagc     4380

acagatggtg tggtggggat acagggtgag tcagaagtca aatccaaaca ggacagtagc     4440

cctgggcctg cctctgtcct gacttcagag tcagtaccct ctctaagcct tgagatcccc     4500

acctgcaacc aaggacactt cctacttccc tgccccctgg gacacaatgc acagagtagg     4560

gcagccaccg tggcttggtt tcctctttgg tgtactgtgt agtgactgtc tcagtgagga     4620

cctggcatga aaggcctggg atagcctgtg gcacacagac cacactgagt aactgttgtc     4680

cctctgcagt gagtatggaa ggcctgggcc tagacatatc cactccccct ccctctgctc     4740

aggatttaga gtccctcaag tgaagactgg gggggggggc agaagggaga aacccaggga     4800

gggagggggc aggagaggaa ggctggccca ggaagataag gtctcggctg ctatatgtac     4860

caggatgagc aggggtcctt ccaaatgtct tgtttagaga actaagaatc tgtcagtgga     4920

aaagatcaaa gagtctaagt cccatccttc attttagagt tcagagactt gaacttatgc     4980

cagctctctg gttcatcctt aaaagtgcac ctgctgggtt gagcctggcc tccctcctgg     5040

ccccttcagc tcttccttag tggatggaga tgccttgtga tggcttagcc taggcatctg     5100

ccatgcacct tatatgctca aggctatttc ttgctcccag cattgactga cattgaatca     5160

ggccccctct tagctgatct aaatataggc ttcacagcaa ggagtgctgg ttctagctac     5220

cctgcaaaca atcccaaccc ctgctactcc ccagcggact taaggcctct cctgcctggt     5280

ttaggttcag ctcctgggac agaggtgact caagcgccct tgtcacaggc taaactctaa     5340

gctgtctttc ctaatcttgc ctcccaccct ggtctgagct gaggtcttat cgcctagcct     5400

tcactgttgt tcagaggcgg ccaaatccgt tttcccgcct ttgccgggca tatcacagat     5460

gtagccttca gtgagtggct ggtcatgggt gggtctggga ctcctcccag gctttctgag     5520

cctgaagagt ctggagtgcg gggaagataa aggactccac gggggttctc tgtctcccag     5580

ggccatggga cactgcacag gctaggacag ggataggaac cattaatggg agaggaatca     5640

gatgctgttc tagaggactg ggcaggagac atctagcgag gtaggcatgc ttcccacctt     5700

aggaactggg cagacccttt gactcatttg ggcctccggt tctctcccag tccctgacta     5760

agaagttaaa tgttgatgcc caacaccgga gttgatagac attcacctct ctctgtcttc     5820

atccacacag agaccgaatg tccagatgaa gtggttgggt ctcctcatgt ctctttccat     5880

gattaataga cggaaatgcc ccaccatttc tggagagggg actgcgggct taggtgctga     5940

ctgcagcagc tccccctgca ggacaataca ggcttcaatt aagtctctac ttgcctcact     6000

agcctcaagt ccctttaagc acagccccac cccctacccc acccccctgc tacatctggg     6060

ttgtgagaac ctgggatgct caccagcctt ccaggctggg tagcacacct taaagtaaag     6120

gaaattagcc tggggaagtg gcgagtctgc ccaaatctcc cccatgagct tctcttttag     6180

agagtactgt tgtttagttt ggtttgcttt gttgggacag ggtctttcta tgtttgtcct     6240

ggctggcctg aaacatgatc tatagaccag gctggccttg aactcaggga ggttctactg     6300

tccctgcctc ctgagagctg ggactaaagg cacgcaccac cacacctggc tttttcatga     6360

gccatcaatc taaaatctaa gctcagattg tgtggtgtct tgagtgtgtt gaactggcct     6420

caagaacaac ttttaaaatt tgttgtttga ggcagggttt ctaccagtct ggccctgaac     6480

tcatattagc tgaggatgac ttcgaattgt ggcttctcct gtgtccactt tccaagagct     6540

ggactataag aaggcaccgc cataattggt cataagctta taacttcgta tagcatacat     6600

tatacgaagt tatcatatgc agtggagctg caccccagcc cttcaagtag cactaactgg     6660

ggtccacaag tgcctgcttc agggacccta gccagccctt ccttctcttt gccaaaacag     6720

tccaggctga ctcaagtttc taagcatgaa tgtactctgc ctgtgactaa ctcaccgttc     6780

ttgggggagc cagatgatca aagttaaagc gtcaataagt ttggttcctt ctggaagttc     6840

caaaaaaatc agttcatgga tctctctgag ctcttggtag caggaaccta gagaggcctg     6900

gctctactcc ctgcttttga tacacaagtc actctccctg cgcccagctt tccctcttct     6960

tgtagggagg gacatctggg gagcaaggcc tatcttatct tcaggcacat cttaacttga     7020

tgtgatattc acaggtgtca ggtggatgtg aactttgggg aacgttatac aagccagcat     7080

gggatagtgt gcctttgatc caaaggacta gcgcttgtca ctcttagtca ctcccattgc     7140

ccctcctccc ccgcaggtgt ggcgtgcacg cagaaaaatg ccacggtcct ttctagtgaa     7200

gagtaagaag gcacacactt accaccagcc ccgggcacag ggtgatgagc tggtctggcc     7260

tcctgctgta attcctggtg agtctgagct taggctatat ggcccacctc atgcctgctt     7320

ggcactgtct tgatgatgct gtggcatttc ttctgtatct aactgtcact gaatgaatga     7380

atggacaagt gaataaatga atgaatgaaa taaatactca tctcctctag cctttggagt     7440

tgagggagca tcggactcag agcctggaaa ggactatggc tccagttgag atctgaagtc     7500

agggtgctct gggtttcccc cacctctgcc tgttctgaac agaggtgtca gcagcagcag     7560

gctggtgtcc ctgggtcccc tctccatgat atggtacccc ttgctctctg agggcattcc     7620

agagcttctg gtggtgactc ttgggtcttg tctcctcaca gtggcaaaag agcatagcca     7680

gagtgccagc cctcttctca gcacaccgct tccaagccag accttggact ggaacacaat     7740

caaacaggag cgggagatgt tgctgaacca gagccttccc aagatggcct cagccccagg     7800

tacccagcca gggtcatcac gtcccctgca ggtgccacag aggaaagtgg tagcacctac     7860

agaggctctg gagtagcact tcttaggata atgatattgg ggagcatcag tcactggaca     7920

ctgtctggac tctcagcatc tgctggacac ttctggacag gcatttgctc taaatgaggg     7980

tgtttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtagc aactgggggg     8040

tccatagggc agtggcctgg tggtccccca ggggagggag ctgaaactgc agtgaagact     8100

cacaccaatg gtacacagta gggctgcata ctggaaccct caacaggagg tcaccaggag     8160

agatacagca cccgggcaac ttatttcaaa attaataacc tgaaccaggt gtgccggttc     8220

atgcctctaa tcccagcact tgggacgcag aggcaagcag atctctgtca gttgaaggcc     8280

agtctggtct acatagagag ttctaggaca gcaaagggta tagaaagaga ccctatttag     8340

aaagaaagag agagaaagaa aggaagggaa gggaaggaaa gggaagaggt ggagaaagag     8400

agagagagac cactggtggc agttaggaat ggtcactgag caccacaagg cagcttacag     8460

ttgcctgtgg ctccatctgg ggagtccaac accatcttct agcctctgag ggcacccgca     8520

cacacacggt atacacaggt acaacatata tagagagttg aaggcaaatc gttaaaataa     8580

attaccctca catgtctttg tacagagggg cctctcgtga caccccaacc ccaggatggg     8640

gaatcaccac tctctgagtc accccctttc tacaagccca gcttctcctg ggataccttg     8700

gcctcctcct acagccacag ctacacacag accccctcca ccatgcagtc cgccttcctg     8760

gagcgctccg tgaggctgta cggcagcccc ctcgtgccca gcacagagtc tcccttggac     8820

ttccgcctcc gctactctcc aggcatggac acttaccact gtgtcaagtg caacaaggtg     8880

agcaatgggc atgcaggccc cgttcagctc agcatctatt ctctccagga tgctgtccct     8940

gctattattt atggctttgg gtggtcctta tgctgggaat cttgaggcca tgctggattc     9000

agaccaagcc ctaactgtct tgcctttgca tcttgccttt gcttgacatg aataagttct     9060

tgggggatat agagagagca aaacacctac cctagtccac aacaaggaga tgggtcgagt     9120

accgggcccc ccctcgacga agttcctata ctttctagag aataggaact tcctcgacgg     9180

tatcgataag ctacttagaa ccacaaagtg ggaatcaaga gaaaaacaat gatcccacga     9240

gagatctata gatctataga tcatgagtgg gaggaatgag ctggccctta atttggtttt     9300

gcttgtttaa attatgatat ccaactatga aacattatca taaagcaata gtaaagagcc     9360

ttcagtaaag agcaggcatt tatctaatcc caccccaccc ccacccccgt agctccaatc     9420

cttccattca aaatgtaggt actctgttct cacccttctt aacaaagtat gacaggaaaa     9480

acttccattt tagtggacat ctttattgtt taatagatca tcaatttctg cagacttaca     9540

gcggatcgat cccctcagaa gaactcgtca agaaggcgat agaaggcgat gcgctgcgaa     9600

tcgggagcgg cgataccgta aagcacgagg aagcggtcag cccattcgcc gccaagctct     9660

tcagcaatat cacgggtagc caacgctatg tcctgatagc ggtccgccac acccagccgg     9720

ccacagtcga tgaatccaga aaagcggcca ttttccacca tgatattcgg caagcaggca     9780

tcgccatggg tcacgacgag atcctcgccg tcgggcatgc gcgccttgag cctggcgaac     9840

agttcggctg gcgcgagccc ctgatgctct tcgtccagat catcctgatc gacaagaccg     9900

gcttccatcc gagtacgtgc tcgctcgatg cgatgtttcg cttggtggtc gaatgggcag     9960

gtagccggat caagcgtatg cagccgccgc attgcatcag ccatgatgga tactttctcg    10020

gcaggagcaa ggtgagatga caggagatcc tgccccggca cttcgcccaa tagcagccag    10080

tcccttcccg cttcagtgac aacgtcgagc acagctgcgc aaggaacgcc cgtcgtggcc    10140

agccacgata gccgcgctgc ctcgtcctgc agttcattca gggcaccgga caggtcggtc    10200

ttgacaaaaa gaaccgggcg cccctgcgct gacagccgga acacggcggc atcagagcag    10260

ccgattgtct gttgtgccca gtcatagccg aatagcctct cccaaggcgg ccggagaacc    10320

tgcgtgcaat ccatcttgtt caatggccga tcccattatg acctgcaggt cgaaaggccc    10380

ggagatgagg aagaggagaa cagcgcggca gacgtgcgct tttgaagcgt gcagaatgcc    10440

gggctccgga ggaccttcgc gcccgccccg cccctgagcc cgcccctgag cccgcccccg    10500

gacccacccc ttcccagcct ctgagcccag aaagcgaagg agccaagctg ctattggccg    10560

ctgccccaaa ggcctacccg cttccattgc tcagcggtgc tgtccatctg cacgagacta    10620

gtgagacgtg ctacttccat ttgtcacgtc ctgcacgacg cgagctgcgg ggcggggggg    10680

aacttcctga ctaggggagg agtagaaggt ggcgcgaagg ggccaccaaa gaagggagcc    10740

ggttggcgct accggtggat gtggaatgtg tgcgaggcca gaggccactt gtgtagcgcc    10800

aagtgccagc ggggctgcta aagcgcatgc tccagactgc cttgggaaaa gcgcctcccc    10860

tacccggtag aattggccgc gaagttccta tactttctag agaataggaa cttcggccgc    10920

caccgcggtg agagcttata acttcgtata gcatacatta tacgaagtta ttctagagaa    10980

ttcctgcagc ccatcagaaa cagcatctac gtggtcctag atagctttgg cattcttttt    11040

tttttttttt tttttttttt ttttgagaca aggtctcatg tagctcaggc tggacctgag    11100

ctctctttgt agccaaggat aaccctgaac tctttatctt tctccctcca cctcctcaag    11160

tattcaccac cacagctagt tttgcctgct ttaatgcagt actagggcct catgtgtaat    11220

atacaagcgc tctatcaact gagctacctc tcagtcccct agccctgaga tcttacccat    11280

gggttattcg tcctccagat gttcatggag gagccttctg gttccctccc acagccccat    11340

tttatagata ggaaactgcc acagagaggt gagcgactcc ctgggatgtg cagcagaaca    11400

gccggaccgc ctgaggtgcc cttctcctgc tctatcctgc tctggagtta ggcccatggc    11460

cagggtgacc acaggcctgc ctccttccag ggacctgact ctttgctctg ccccaggtgt    11520

tctccacccc tcatgggcta gaagtgcatg tccgccgctc tcacagcgga acccggccct    11580

ttgcctgtga tgtctgtggc aaaacctttg gccacgctgt gagcttggag cagcatactc    11640

acgtccactc acaggtgagt aactgacaaa ggctgaaggg gacaaaggtg ggggaggagc    11700

aaaggtggag gaggagcaaa ggtggaggag gagcaaaggt gggggaggag caaaggtggg    11760

ggaggagcaa aggtggggga ggagtaaagg tgggggagga gcagactccc tgacttgtct    11820

ccctgggtct gagtcatcta acatactggg tctctgattg gctgaaatgg tttcacatct    11880

agttggaagg aactggggat ttaggggtgg gagctgggtt atgtcagtga gaagccatcc    11940

tatgctctgt gtggccccgc aggcatcctc aattcttaga gttttagagt tcaatttaaa    12000

tacacgtcct ccctcccacc cccaccccat ctctgtttgg gacccattcc tttccagagc    12060

agaacaggta actaaccagc actctgtctg ggtcacacag gccggttacc aacacctggg    12120

gaggtgggaa aggtggtggg aggtgaccct cgaaccttcc gtccctcggc aacaggctgg    12180

aagctggctc tgtcttctac ttcgaagcct cccacagacc aaccaggcca ggctagaact    12240

gccccagtgc acagatgagg aaaacaatgg gcttgcccca agcatacggc tgctgggctg    12300

ctgggagtag ggtctcagct ggtagagtgc ttgcctagta cacagaagcc ctaacaccag    12360

atgaaccagg aatggcaggc ctagaacagc actcaggagg tggaagctca aagttatcac    12420

tgcctacata ataagttcaa ggccaaactg ggctacccaa gaacctatcc taactaaatt    12480

gagtcagcat gtcactagct aagaggaact cactctgcgt tactggtgaa tccctgaaaa    12540

acttagttgc ttcatcaatc agtcaccaaa cacaccctga ggcttatttt gaaaagtata    12600

ctgtgaaagg cacagggaga gatttcagag gaagcaaatc aggcccaaag cctcagtcct    12660

cagttgagga agcaggaatg gggcggggtt cttcctgctt ctctggaccc ctgttctcga    12720

ggccacccca acggagtgtc ctctttctca gggcgtccca gccgggtcca gtcctacgcc    12780

caccttggct gtcccgggcc ttgaggcccc acctgcacct gaccccccag ggcctcgttt    12840

cctccggcag gagcgaagct tcgagtgccg gatgtgtggc aaagccttca agcgttcatc    12900

caccctgtcc acccacctgc tcatccactc ggacactcgg ccctacccct gccagttctg    12960

tgggaagcgc ttccaccaga agtcggacat gaagaaacac acctacatcc acacaggtga    13020

gcacccaggc cgagttcgag ggaaggccat aggatcgcct gcctggcttc ccccatcatt    13080

tgccaagagg cccccttgag gagggtctgg agggctgcac aatcactcaa agtaaagaaa    13140

cactggcagg aaagccaagc caacaaaggc ctgagggcag aaggccagcg tgggcgtgga    13200

ttctccaccc cctgtcgctc actctgtcca ctctacagag tgagcggcct tgcgcagcca    13260

aggaatcaag gaagggccag cctgtgccag cttggaccag ctgagaaagc cagaaatcta    13320

gagaaagact gtaccagtaa cctgacacat tatggtgaca tagatgcctg acaaaatgtc    13380

actgggcctc acagtttgag acggagtcca tcacggcagg actgctcagt ggtaggagca    13440

tgaggcagct ggtcacactg ctttaggaag gagagggcgg aatgctggtg tgcagcttgc    13500

tctccccctt ttattctgtc agtcccagcc catgggacag tgccagctgc catatttagg    13560

atgaaccttc agttagcccc cgcccccccc aaattcctca cagacattcc cagcagtgtg    13620

tctcctgggt gacctaagtc ccatcaagta gacagtgttg cccatcagaa aagcattttg    13680

cttgtttgtg tgcttgcttg cttattgaga caaatactca ggtagctgag gctagccttg    13740

gagttaatat gtagttgagg ctgacctcaa cctctaactt gcaatttctc tccctcagga    13800

tgagagggtt acagatgtat gcatttcctt cctttcttcc tccccccttc cttccctccc    13860

ccccttcctt ccctcccttc ctcccttcct tccttccttc cttttttgtt gttgttgttt    13920

tgttctgttt tggtttggtt tagggttatt tgttattttt ttttcttttt gtttttgggg    13980

gatagggttt ctctgtgtgt aggcctggct gtcctggaac tcactctata aatcaagctg    14040

gccttgaact cagagatcca tctgcctctg tctcccaagg gctgggatca aaggtgtggc    14100

catcacactt aactactttc caccattttc taaggttggc cataaaaacc cagtagcgaa    14160

tgtgtgacag ggtggtggct gcacgcctag cactgccacc tgaacccacc tgcggtttgt    14220

cccttcccca ggtgagaagc cccacaagtg ccaggtgtgt gggaaagcct tcagccagag    14280

ctccaacctc atcacccaca gccgcaagca cacaggcttc aagccgttca gctgtgagct    14340

gtgcaccaag ggcttccagc gcaaggtgga cctgcgacgt caccgtgaga gtcaacacaa    14400

tctcaagtga gacggttggc cgcctgcttt agtgtgtctc gcctgaaggc cagcctctcc    14460

tttccaatcc tgatcccagt cctcctggaa gcagcattgc ccatgagcct ctctgcttct    14520

tttgagactg gatgacctca accaagccac actcctcctc tgaccacagc tgatgtggga    14580

gtcagttcgg gcctttctga actgaggcag tcacagacat gctctggtct cattcaatgc    14640

cagagcacag acagctacaa agccctcgtg gacatggcaa aaccaggcaa gagccaggat    14700

ccacagagaa accctcttgc ttgcttctct gggtctagtg actgaatttt tagggattct    14760

ctttttggct gccacagtca gagttgtccc ctggcctaga ggtctggcgc ccctctgctt    14820

cggccagatg tgctctctgt cccccacctc tcaccacatc catccgccca ctgggagtca    14880

ggctcctgag gtgagccacg aggctatgaa atcagccatg atagtagaag cctgctccta    14940

tcagttgatg taaatgtaaa taaaggtggg tttatttaca tgtgaccttg tttgtaaaac    15000

tcctactagg tccccaggac tgcctgagga cttgagggcc ttgacaggga gctaacagag    15060

agaagcacca tgacaggtgt ccag                                           15084


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
ggtttctacc agtctggccc tgaactc                                           27


<210>  11
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
ctcacctctc tgtggcagtt tcctatc                                           27


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
tacattcatg cttagaaact tgagtc                                            26


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRIAD1 siRNA

<400>  13
uugugaggaa gaggaagaa                                                    19


<210>  14
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRIAD1 siRNA

<400>  14
aauugugagg aagaggaaga a                                                 21


<210>  15
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFI1B shRNA

<400>  15
gcctagcttc tcctgggact tcaagagagt cccaggagaa gctag                       45


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFI1B shRNA

<400>  16
cccattctac aagcctagct t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFI1B shRNA

<400>  17
ccttagcact ctattcccaa a                                                 21


<210>  18
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Thr Tyr His 
1               5                   10                  15      


Gln Pro Arg Val 
            20  


<210>  19
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  19
taaatcacwg ca                                                           12


