                         SEQUENCE LISTING

<110>  ESPERANCE PHARMACEUTICALS, INC.
       ALILA, HECTOR
       LEUSCHNER, CAROLA
       JUBAN,  MARTHA
       COULTER, ANN
 
<120>  Lytic-Peptide-Her2/neu (Human Epidermal growth factor Receptor 2)
        Ligand Conjugates and Methods of Use

<130>  026039-0393024

<140>  PCT/US2011/034338
<141>  2011-04-28

<150>   61/330,005
<151>  2010-04-30

<150>   61/362,603
<151>  2010-07-08

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  1

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys 
1               5                   10                  15  


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  2

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  3

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala 
    


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  4

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys 
        


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  5

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys Phe 
            


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  6

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys Phe Ala 
            20  


<210>  7
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  7

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys 
            20                  25              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  8

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys 
1               5                   10                  15  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  9

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  10

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  11

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys 
        


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  12

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys Phe 
            


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  13

Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala Lys Phe Ala Lys Lys Phe 
1               5                   10                  15      


Ala Lys Phe Ala 
            20  


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker peptide

<400>  14

Gly Ser Gly Gly Ser 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker peptide

<400>  15

Ala Ser Ala Ala Ser 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker peptide

<400>  16

Cys Cys Cys Cys Cys Cys 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker peptide

<400>  17

Gly Ser Gly Arg Ser Ala 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker peptide

<400>  18

Arg Val Arg Arg Ser Val 
1               5       


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Motif

<400>  19

Pro Asn Asn Pro Asn Asn Pro 
1               5           


<210>  20
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  20

Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  21
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  21

Val Asp Asn Lys Phe Asn Lys Glu Leu Arg Gln Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Ala Leu Pro Asn Leu Asn Trp Thr Gln Ser Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  22
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  22

Val Asp Asn Lys Phe Asn Lys Glu Pro Lys Thr Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Val Lys Leu Pro Asn Leu Asn Pro Glu Gln Arg Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  23
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  23

Val Asp Asn Lys Phe Asn Lys Glu Pro Arg Glu Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Gln Arg Leu Pro Asn Leu Asn Asn Lys Gln Lys Ala Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  24
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  24

Val Asp Asn Lys Phe Asn Lys Glu Trp Met Thr Ala Gly Lys Glu Ile 
1               5                   10                  15      


Tyr Arg Leu Pro Asn Leu Asn Gly Thr Gln Val Arg Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  25
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  25

Val Asp Asn Lys Phe Asn Lys Glu Trp Val Gln Ala Gly Ser Glu Ile 
1               5                   10                  15      


Tyr Asn Leu Pro Asn Leu Asn Arg Ala Gln Met Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  26
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  26

Val Asp Asn Lys Phe Asn Lys Glu Ile Lys Gln Ala Phe His Glu Ile 
1               5                   10                  15      


Val Arg Leu Pro Asn Leu Asn Ala Asp Gln Val Arg Ala Phe Ile Tyr 
            20                  25                  30          


Ser Leu Gly Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  27
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  27

Val Asp Asn Lys Phe Asn Lys Glu Met Val Asp Ala Gly Ala Glu Ile 
1               5                   10                  15      


Trp Arg Leu Pro Asn Leu Asn Ala Lys Gln Met Ala Phe Ile Asp Ser 
            20                  25                  30          


Leu Gly Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
        35                  40                  45              


Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55          


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  31
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  43
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence:  Heavy chain mammalian 
       humanized antibody

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  48
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Asp Trp Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  49
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Trp Gly Pro Lys Leu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  50
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Glu Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  51
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  52
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  52

Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
            20                  25                  30          


Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile 
                85                  90                  95      


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  53
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Val Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  54
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Light chain mammalian 
       humanized antibody

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Glu Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  55
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Heavy chain mammalian 
       humanized antibody

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Lytic peptide

<400>  56

Lys Leu Ala Lys Leu Ala Lys Lys Lys Leu Ala Lys 
1               5                   10          


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker

<400>  57

Asn Arg Val Arg Arg Ser 
1               5       


<210>  58
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  58
catatgcatc accaccacca ccacgacgac gacgacaaag atattcaaat gacccagtcc       60

ccgagcagcc tgagtgcctc cgttggcgac cgcgtgacca ttacgtgccg tgcgagccag      120

gatgtcaaca ccgcggtggc ctggtatcag caaaaaccgg gcaaagcgcc gaaactgctg      180

atctattcag cctcgtttct gtacagcggt gttccgtctc gtttcagcgg ctctcgcagt      240

ggtaccgatt ttaccctgac gattagctct ctgcagccgg aagactttgc gacgtattac      300

tgccagcaac attacaccac gccgccgacc ttcggccagg gtacgaaagt ggaaatcaaa      360

ggttccacct caggcggtgg cagtggtggc ggttccggcg gtggcggtag ttccgaagtt      420

cagctggtcg aaagtggcgg tggcctggtt caaccgggtg gctcactgcg tctgtcgtgt      480

gcagcaagcg gtttcaacat caaagatacc tacatccact gggttcgtca ggcgccgggc      540

aaaggtctgg aatgggtcgc ccgcatttac ccgaccaatg gctatacgcg ttacgcagat      600

agcgtgaaag gtcgctttac catctctgcg gacaccagta aaaacacggc ctatctgcag      660

atgaatagcc tgcgtgcgga agatacggcc gtttattact gctctcgctg gggtggcgat      720

ggcttctatg ctatggacta ctggggccag ggtaccctgg tgacggtttc atcgggtcag      780

ccgcgtgaac cgcaagtgta taccctgccg ccgtcacgcg atgaactgac gaaaaaccag      840

gtgtcgctga cgtgtctggt taaaggcttt tacccgagcg acatcgcggt tgaatgggaa      900

tctaatggtc aaccggaaaa caattataaa accacgccgc cggtcctgga tagtgacggc      960

tcctttttcc tgtacagtaa actgaccgtg gataaatccc gttggcagca gggtaacgtc     1020

ttctcgtgta gcgtgatgca tgaagccctg cataatcact atacccagaa atctctgagt     1080

ctgtccccgg gcaaaggttc aacgtcgggt ggcggttccg gcggtggctc aggtggcggt     1140

ggcagctctg gccaaccgcg cgaaccgcag gtttacaccc tgccgccgag ccgtgacgaa     1200

ctgaccaaaa accaagtcag cctgacgtgc ctggtgaaag gcttttaccc gagtgacatt     1260

gcagttgaat gggaatccaa tggtcagccg gaaaataact acaaaacgac gccgccggtt     1320

ctggattcag acggctcgtt tttcctgtac tcaaaactga ccgtcgataa atcgcgctgg     1380

caacagggta acgttttcag ctgctctgtc atgcacgaag ccctgcacaa ccattatacc     1440

cagaaaagtc tgtccctgtc accgggcaaa gaagtgcagc tggttgaatc tggtggcggt     1500

ctggtgcaac cgggcggttc gctgcgtctg agctgtgcag cttctggctt taatattaaa     1560

gacacgtaca tccactgggt gcgtcaggca ccgggtaaag gcctggaatg ggttgctcgt     1620

atctatccga cgaacggtta tacgcgttac gccgatagcg tcaaaggccg ttttaccatc     1680

agtgcagaca cctccaaaaa cacggcttat ctgcagatga atagtctgcg tgcagaagat     1740

accgctgttt attactgcag ccgctggggc ggtgatggct tctatgcaat ggattattgg     1800

ggtcaaggta ccctggtcac cgtgagttcc ggttcgacca gcggcggtgg ctcaggtggc     1860

ggttcgggcg gtggcggttc atcggacatt cagatgacgc aaagcccgag ctctctgtct     1920

gcgagtgttg gcgatcgtgt caccatcacg tgtcgcgcct ctcaggacgt gaataccgca     1980

gttgcttggt accaacaaaa accgggcaaa gcaccgaaac tgctgattta ctccgcttca     2040

ttcctgtaca gcggtgtgcc gtctcgtttt tcgggcagcc gctctggtac cgatttcacc     2100

ctgacgatta gttccctgca accggaagat ttcgccacct actactgcca gcaacactat     2160

acgaccccgc cgacgtttgg tcagggcacg aaagtggaaa ttaaataatg aaagctt        2217


<210>  59
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  59
catatgcatc accaccacca ccacgacgac gacgacaaag atattcaaat gacccagtcc       60

ccgagcagcc tgagtgcctc cgttggcgac cgcgtgacca ttacgtgccg tgcgagccag      120

gatgtcaaca ccgcggtggc ctggtatcag caaaaaccgg gcaaagcgcc gaaactgctg      180

atctattcag cctcgtttct gtacagcggt gttccgtctc gtttcagcgg ctctcgcagt      240

ggtaccgatt ttaccctgac gattagctct ctgcagccgg aagactttgc gacgtattac      300

tgccagcaac attacaccac gccgccgacc ttcggccagg gtacgaaagt ggaaatcaaa      360

ggttccacct caggcggtgg cagtggtggc ggttccggcg gtggcggtag ttccgaagtt      420

cagctggtcg aaagtggcgg tggcctggtt caaccgggtg gctcactgcg tctgtcgtgt      480

gcagcaagcg gtttcaacat caaagatacc tacatccact gggttcgtca ggcgccgggc      540

aaaggtctgg aatgggtcgc ccgcatttac ccgaccaatg gctatacgcg ttacgcagat      600

agcgtgaaag gtcgctttac catctctgcg gacaccagta aaaacacggc ctatctgcag      660

atgaatagcc tgcgtgcgga agatacggcc gtttattact gctctcgctg gggtggcgat      720

ggcttctatg ctatggacta ctggggccag ggtaccctgg tgacggtttc atcgggtcag      780

ccgcgtgaac cgcaagtgta taccctgccg ccgtcacgcg atgaactgac gaaaaaccag      840

gtgtcgctga cgtgtctggt taaaggcttt tacccgagcg acatcgcggt tgaatgggaa      900

tctaatggtc aaccggaaaa caattataaa accacgccgc cggtcctgga tagtgacggc      960

tcctttttcc tgtacagtaa actgaccgtg gataaatccc gttggcagca gggtaacgtc     1020

ttctcgtgta gcgtgatgca tgaagccctg cataatcact atacccagaa atctctgagt     1080

ctgtccccgg gcaaaggttc aacgtcgggt ggcggttccg gcggtggctc aggtggcggt     1140

ggcagctctg gccaaccgcg cgaaccgcag gtttacaccc tgccgccgag ccgtgacgaa     1200

ctgaccaaaa accaagtcag cctgacgtgc ctggtgaaag gcttttaccc gagtgacatt     1260

gcagttgaat gggaatccaa tggtcagccg gaaaataact acaaaacgac gccgccggtt     1320

ctggattcag acggctcgtt tttcctgtac tcaaaactga ccgtcgataa atcgcgctgg     1380

caacagggta acgttttcag ctgctctgtc atgcacgaag ccctgcacaa ccattatacc     1440

cagaaaagtc tgtccctgtc accgggcaaa gaagtgcagc tggttgaatc tggtggcggt     1500

ctggtgcaac cgggcggttc gctgcgtctg agctgtgcag cttctggctt taatattaaa     1560

gacacgtaca tccactgggt gcgtcaggca ccgggtaaag gcctggaatg ggttgctcgt     1620

atctatccga cgaacggtta tacgcgttac gccgatagcg tcaaaggccg ttttaccatc     1680

agtgcagaca cctccaaaaa cacggcttat ctgcagatga atagtctgcg tgcagaagat     1740

accgctgttt attactgcag ccgctggggc ggtgatggct tctatgcaat ggattattgg     1800

ggtcaaggta ccctggtcac cgtgagttcc ggttcgacca gcggcggtgg ctcaggtggc     1860

ggttcgggcg gtggcggttc atcggacatt cagatgacgc aaagcccgag ctctctgtct     1920

gcgagtgttg gcgatcgtgt caccatcacg tgtcgcgcct ctcaggacgt gaataccgca     1980

gttgcttggt accaacaaaa accgggcaaa gcaccgaaac tgctgattta ctccgcttca     2040

ttcctgtaca gcggtgtgcc gtctcgtttt tcgggcagcc gctctggtac cgatttcacc     2100

ctgacgatta gttccctgca accggaagat ttcgccacct actactgcca gcaacactat     2160

acgaccccgc cgacgtttgg tcagggcacg aaagtggaaa ttaaaggcag caaatttgcg     2220

aaattcgcca aaaaattcgc aaaattcgcg aaaaaattcg cgaaataatg aaagctt        2277


<210>  60
<211>  2265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  60
catatggaaa atctgtattt ccaaggtgat attcaaatga cccagtcccc gagcagcctg       60

agtgcctccg ttggcgaccg cgtgaccatt acgtgccgtg cgagccagga tgtcaacacc      120

gcggtggcct ggtatcagca aaaaccgggc aaagcgccga aactgctgat ctattcagcc      180

tcgtttctgt acagcggtgt tccgtctcgt ttcagcggct ctcgcagtgg taccgatttt      240

accctgacga ttagctctct gcagccggaa gactttgcga cgtattactg ccagcaacat      300

tacaccacgc cgccgacctt cggccagggt acgaaagtgg aaatcaaagg ttccacctca      360

ggcggtggca gtggtggcgg ttccggcggt ggcggtagtt ccgaagttca gctggtcgaa      420

agtggcggtg gcctggttca accgggtggc tcactgcgtc tgtcgtgtgc agcaagcggt      480

ttcaacatca aagataccta catccactgg gttcgtcagg cgccgggcaa aggtctggaa      540

tgggtcgccc gcatttaccc gaccaatggc tatacgcgtt acgcagatag cgtgaaaggt      600

cgctttacca tctctgcgga caccagtaaa aacacggcct atctgcagat gaatagcctg      660

cgtgcggaag atacggccgt ttattactgc tctcgctggg gtggcgatgg cttctatgct      720

atggactact ggggccaggg taccctggtg acggtttcat cgggtcagcc gcgtgaaccg      780

caagtgtata ccctgccgcc gtcacgcgat gaactgacga aaaaccaggt gtcgctgacg      840

tgtctggtta aaggctttta cccgagcgac atcgcggttg aatgggaatc taatggtcaa      900

ccggaaaaca attataaaac cacgccgccg gtcctggata gtgacggctc ctttttcctg      960

tacagtaaac tgaccgtgga taaatcccgt tggcagcagg gtaacgtctt ctcgtgtagc     1020

gtgatgcatg aagccctgca taatcactat acccagaaat ctctgagtct gtccccgggc     1080

aaaggttcaa cgtcgggtgg cggttccggc ggtggctcag gtggcggtgg cagctctggc     1140

caaccgcgcg aaccgcaggt ttacaccctg ccgccgagcc gtgacgaact gaccaaaaac     1200

caagtcagcc tgacgtgcct ggtgaaaggc ttttacccga gtgacattgc agttgaatgg     1260

gaatccaatg gtcagccgga aaataactac aaaacgacgc cgccggttct ggattcagac     1320

ggctcgtttt tcctgtactc aaaactgacc gtcgataaat cgcgctggca acagggtaac     1380

gttttcagct gctctgtcat gcacgaagcc ctgcacaacc attataccca gaaaagtctg     1440

tccctgtcac cgggcaaaga agtgcagctg gttgaatctg gtggcggtct ggtgcaaccg     1500

ggcggttcgc tgcgtctgag ctgtgcagct tctggcttta atattaaaga cacgtacatc     1560

cactgggtgc gtcaggcacc gggtaaaggc ctggaatggg ttgctcgtat ctatccgacg     1620

aacggttata cgcgttacgc cgatagcgtc aaaggccgtt ttaccatcag tgcagacacc     1680

tccaaaaaca cggcttatct gcagatgaat agtctgcgtg cagaagatac cgctgtttat     1740

tactgcagcc gctggggcgg tgatggcttc tatgcaatgg attattgggg tcaaggtacc     1800

ctggtcaccg tgagttccgg ttcgaccagc ggcggtggct caggtggcgg ttcgggcggt     1860

ggcggttcat cggacattca gatgacgcaa agcccgagct ctctgtctgc gagtgttggc     1920

gatcgtgtca ccatcacgtg tcgcgcctct caggacgtga ataccgcagt tgcttggtac     1980

caacaaaaac cgggcaaagc accgaaactg ctgatttact ccgcttcatt cctgtacagc     2040

ggtgtgccgt ctcgtttttc gggcagccgc tctggtaccg atttcaccct gacgattagt     2100

tccctgcaac cggaagattt cgccacctac tactgccagc aacactatac gaccccgccg     2160

acgtttggtc agggcacgaa agtggaaatt aaaggcagca aactggcgaa actggccaaa     2220

aaactggcaa aactggcgaa aaaactggcg aaataatgaa agctt                     2265


<210>  61
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  61
catatggaaa atctgtattt ccaaggtgat attcaaatga cccagtcccc gagcagcctg       60

agtgcctccg ttggcgaccg cgtgaccatt acgtgccgtg cgagccagga tgtcaacacc      120

gcggtggcct ggtatcagca aaaaccgggc aaagcgccga aactgctgat ctattcagcc      180

tcgtttctgt acagcggtgt tccgtctcgt ttcagcggct ctcgcagtgg taccgatttt      240

accctgacga ttagctctct gcagccggaa gactttgcga cgtattactg ccagcaacat      300

tacaccacgc cgccgacctt cggccagggt acgaaagtgg aaatcaaagg ttccacctca      360

ggcggtggca gtggtggcgg ttccggcggt ggcggtagtt ccgaagttca gctggtcgaa      420

agtggcggtg gcctggttca accgggtggc tcactgcgtc tgtcgtgtgc agcaagcggt      480

ttcaacatca aagataccta catccactgg gttcgtcagg cgccgggcaa aggtctggaa      540

tgggtcgccc gcatttaccc gaccaatggc tatacgcgtt acgcagatag cgtgaaaggt      600

cgctttacca tctctgcgga caccagtaaa aacacggcct atctgcagat gaatagcctg      660

cgtgcggaag atacggccgt ttattactgc tctcgctggg gtggcgatgg cttctatgct      720

atggactact ggggccaggg taccctggtg acggtttcat cgggtcagcc gcgtgaaccg      780

caagtgtata ccctgccgcc gtcacgcgat gaactgacga aaaaccaggt gtcgctgacg      840

tgtctggtta aaggctttta cccgagcgac atcgcggttg aatgggaatc taatggtcaa      900

ccggaaaaca attataaaac cacgccgccg gtcctggata gtgacggctc ctttttcctg      960

tacagtaaac tgaccgtgga taaatcccgt tggcagcagg gtaacgtctt ctcgtgtagc     1020

gtgatgcatg aagccctgca taatcactat acccagaaat ctctgagtct gtccccgggc     1080

aaaggttcaa cgtcgggtgg cggttccggc ggtggctcag gtggcggtgg cagctctggc     1140

caaccgcgcg aaccgcaggt ttacaccctg ccgccgagcc gtgacgaact gaccaaaaac     1200

caagtcagcc tgacgtgcct ggtgaaaggc ttttacccga gtgacattgc agttgaatgg     1260

gaatccaatg gtcagccgga aaataactac aaaacgacgc cgccggttct ggattcagac     1320

ggctcgtttt tcctgtactc aaaactgacc gtcgataaat cgcgctggca acagggtaac     1380

gttttcagct gctctgtcat gcacgaagcc ctgcacaacc attataccca gaaaagtctg     1440

tccctgtcac cgggcaaaga agtgcagctg gttgaatctg gtggcggtct ggtgcaaccg     1500

ggcggttcgc tgcgtctgag ctgtgcagct tctggcttta atattaaaga cacgtacatc     1560

cactgggtgc gtcaggcacc gggtaaaggc ctggaatggg ttgctcgtat ctatccgacg     1620

aacggttata cgcgttacgc cgatagcgtc aaaggccgtt ttaccatcag tgcagacacc     1680

tccaaaaaca cggcttatct gcagatgaat agtctgcgtg cagaagatac cgctgtttat     1740

tactgcagcc gctggggcgg tgatggcttc tatgcaatgg attattgggg tcaaggtacc     1800

ctggtcaccg tgagttccgg ttcgaccagc ggcggtggct caggtggcgg ttcgggcggt     1860

ggcggttcat cggacattca gatgacgcaa agcccgagct ctctgtctgc gagtgttggc     1920

gatcgtgtca ccatcacgtg tcgcgcctct caggacgtga ataccgcagt tgcttggtac     1980

caacaaaaac cgggcaaagc accgaaactg ctgatttact ccgcttcatt cctgtacagc     2040

ggtgtgccgt ctcgtttttc gggcagccgc tctggtaccg atttcaccct gacgattagt     2100

tccctgcaac cggaagattt cgccacctac tactgccagc aacactatac gaccccgccg     2160

acgtttggtc agggcacgaa agtggaaatt aaaaaccgtg tgcgtcgcag caaatttgcg     2220

aaattcgcca aaaaatttgc aaaattcgct aaaaaatttg cgaaataatg aaagctt        2277


<210>  62
<211>  2289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  62

Cys Ala Thr Ala Thr Gly Cys Ala Thr Cys Ala Cys Cys Ala Cys Cys 
1               5                   10                  15      


Ala Cys Cys Ala Cys Cys Ala Cys Gly Ala Cys Gly Ala Cys Gly Ala 
            20                  25                  30          


Cys Gly Ala Cys Ala Ala Ala Gly Ala Thr Ala Thr Thr Cys Ala Ala 
        35                  40                  45              


Ala Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys Cys Cys Cys Gly Ala 
    50                  55                  60                  


Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Thr Gly Cys Cys Thr Cys 
65                  70                  75                  80  


Cys Gly Thr Thr Gly Gly Cys Gly Ala Cys Cys Gly Cys Gly Thr Gly 
                85                  90                  95      


Ala Cys Cys Ala Thr Thr Ala Cys Gly Thr Gly Cys Cys Gly Thr Gly 
            100                 105                 110         


Cys Gly Ala Gly Cys Cys Ala Gly Gly Ala Thr Gly Thr Cys Ala Ala 
        115                 120                 125             


Cys Ala Cys Cys Gly Cys Gly Gly Thr Gly Gly Cys Cys Thr Gly Gly 
    130                 135                 140                 


Thr Ala Thr Cys Ala Gly Cys Ala Ala Ala Ala Ala Cys Cys Gly Gly 
145                 150                 155                 160 


Gly Cys Ala Ala Ala Gly Cys Gly Cys Cys Gly Ala Ala Ala Cys Thr 
                165                 170                 175     


Gly Cys Thr Gly Ala Thr Cys Thr Ala Thr Thr Cys Ala Gly Cys Cys 
            180                 185                 190         


Thr Cys Gly Thr Thr Thr Cys Thr Gly Thr Ala Cys Ala Gly Cys Gly 
        195                 200                 205             


Gly Thr Gly Thr Thr Cys Cys Gly Thr Cys Thr Cys Gly Thr Thr Thr 
    210                 215                 220                 


Cys Ala Gly Cys Gly Gly Cys Thr Cys Thr Cys Gly Cys Ala Gly Thr 
225                 230                 235                 240 


Gly Gly Thr Ala Cys Cys Gly Ala Thr Thr Thr Thr Ala Cys Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Gly Ala Thr Thr Ala Gly Cys Thr Cys Thr Cys Thr 
            260                 265                 270         


Gly Cys Ala Gly Cys Cys Gly Gly Ala Ala Gly Ala Cys Thr Thr Thr 
        275                 280                 285             


Gly Cys Gly Ala Cys Gly Thr Ala Thr Thr Ala Cys Thr Gly Cys Cys 
    290                 295                 300                 


Ala Gly Cys Ala Ala Cys Ala Thr Thr Ala Cys Ala Cys Cys Ala Cys 
305                 310                 315                 320 


Gly Cys Cys Gly Cys Cys Gly Ala Cys Cys Thr Thr Cys Gly Gly Cys 
                325                 330                 335     


Cys Ala Gly Gly Gly Thr Ala Cys Gly Ala Ala Ala Gly Thr Gly Gly 
            340                 345                 350         


Ala Ala Ala Thr Cys Ala Ala Ala Gly Gly Thr Thr Cys Cys Ala Cys 
        355                 360                 365             


Cys Thr Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Cys Ala Gly Thr 
    370                 375                 380                 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Thr Cys Cys Gly Gly Cys Gly 
385                 390                 395                 400 


Gly Thr Gly Gly Cys Gly Gly Thr Ala Gly Thr Thr Cys Cys Gly Ala 
                405                 410                 415     


Ala Gly Thr Thr Cys Ala Gly Cys Thr Gly Gly Thr Cys Gly Ala Ala 
            420                 425                 430         


Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Cys Thr Gly Gly 
        435                 440                 445             


Thr Thr Cys Ala Ala Cys Cys Gly Gly Gly Thr Gly Gly Cys Thr Cys 
    450                 455                 460                 


Ala Cys Thr Gly Cys Gly Thr Cys Thr Gly Thr Cys Gly Thr Gly Thr 
465                 470                 475                 480 


Gly Cys Ala Gly Cys Ala Ala Gly Cys Gly Gly Thr Thr Thr Cys Ala 
                485                 490                 495     


Ala Cys Ala Thr Cys Ala Ala Ala Gly Ala Thr Ala Cys Cys Thr Ala 
            500                 505                 510         


Cys Ala Thr Cys Cys Ala Cys Thr Gly Gly Gly Thr Thr Cys Gly Thr 
        515                 520                 525             


Cys Ala Gly Gly Cys Gly Cys Cys Gly Gly Gly Cys Ala Ala Ala Gly 
    530                 535                 540                 


Gly Thr Cys Thr Gly Gly Ala Ala Thr Gly Gly Gly Thr Cys Gly Cys 
545                 550                 555                 560 


Cys Cys Gly Cys Ala Thr Thr Thr Ala Cys Cys Cys Gly Ala Cys Cys 
                565                 570                 575     


Ala Ala Thr Gly Gly Cys Thr Ala Thr Ala Cys Gly Cys Gly Thr Thr 
            580                 585                 590         


Ala Cys Gly Cys Ala Gly Ala Thr Ala Gly Cys Gly Thr Gly Ala Ala 
        595                 600                 605             


Ala Gly Gly Thr Cys Gly Cys Thr Thr Thr Ala Cys Cys Ala Thr Cys 
    610                 615                 620                 


Thr Cys Thr Gly Cys Gly Gly Ala Cys Ala Cys Cys Ala Gly Thr Ala 
625                 630                 635                 640 


Ala Ala Ala Ala Cys Ala Cys Gly Gly Cys Cys Thr Ala Thr Cys Thr 
                645                 650                 655     


Gly Cys Ala Gly Ala Thr Gly Ala Ala Thr Ala Gly Cys Cys Thr Gly 
            660                 665                 670         


Cys Gly Thr Gly Cys Gly Gly Ala Ala Gly Ala Thr Ala Cys Gly Gly 
        675                 680                 685             


Cys Cys Gly Thr Thr Thr Ala Thr Thr Ala Cys Thr Gly Cys Thr Cys 
    690                 695                 700                 


Thr Cys Gly Cys Thr Gly Gly Gly Gly Thr Gly Gly Cys Gly Ala Thr 
705                 710                 715                 720 


Gly Gly Cys Thr Thr Cys Thr Ala Thr Gly Cys Thr Ala Thr Gly Gly 
                725                 730                 735     


Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly 
            740                 745                 750         


Thr Ala Cys Cys Cys Thr Gly Gly Thr Gly Ala Cys Gly Gly Thr Thr 
        755                 760                 765             


Thr Cys Ala Thr Cys Gly Gly Gly Thr Cys Ala Gly Cys Cys Gly Cys 
    770                 775                 780                 


Gly Thr Gly Ala Ala Cys Cys Gly Cys Ala Ala Gly Thr Gly Thr Ala 
785                 790                 795                 800 


Thr Ala Cys Cys Cys Thr Gly Cys Cys Gly Cys Cys Gly Thr Cys Ala 
                805                 810                 815     


Cys Gly Cys Gly Ala Thr Gly Ala Ala Cys Thr Gly Ala Cys Gly Ala 
            820                 825                 830         


Ala Ala Ala Ala Cys Cys Ala Gly Gly Thr Gly Thr Cys Gly Cys Thr 
        835                 840                 845             


Gly Ala Cys Gly Thr Gly Thr Cys Thr Gly Gly Thr Thr Ala Ala Ala 
    850                 855                 860                 


Gly Gly Cys Thr Thr Thr Thr Ala Cys Cys Cys Gly Ala Gly Cys Gly 
865                 870                 875                 880 


Ala Cys Ala Thr Cys Gly Cys Gly Gly Thr Thr Gly Ala Ala Thr Gly 
                885                 890                 895     


Gly Gly Ala Ala Thr Cys Thr Ala Ala Thr Gly Gly Thr Cys Ala Ala 
            900                 905                 910         


Cys Cys Gly Gly Ala Ala Ala Ala Cys Ala Ala Thr Thr Ala Thr Ala 
        915                 920                 925             


Ala Ala Ala Cys Cys Ala Cys Gly Cys Cys Gly Cys Cys Gly Gly Thr 
    930                 935                 940                 


Cys Cys Thr Gly Gly Ala Thr Ala Gly Thr Gly Ala Cys Gly Gly Cys 
945                 950                 955                 960 


Thr Cys Cys Thr Thr Thr Thr Thr Cys Cys Thr Gly Thr Ala Cys Ala 
                965                 970                 975     


Gly Thr Ala Ala Ala Cys Thr Gly Ala Cys Cys Gly Thr Gly Gly Ala 
            980                 985                 990         


Thr Ala Ala Ala Thr Cys Cys Cys  Gly Thr Thr Gly Gly  Cys Ala Gly 
        995                 1000                 1005             


Cys Ala  Gly Gly Gly Thr Ala  Ala Cys Gly Thr Cys  Thr Thr Cys 
    1010                 1015                 1020             


Thr Cys  Gly Thr Gly Thr Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1025                 1030                 1035             


Cys Ala  Thr Gly Ala Ala Gly  Cys Cys Cys Thr Gly  Cys Ala Thr 
    1040                 1045                 1050             


Ala Ala  Thr Cys Ala Cys Thr  Ala Thr Ala Cys Cys  Cys Ala Gly 
    1055                 1060                 1065             


Ala Ala  Ala Thr Cys Thr Cys  Thr Gly Ala Gly Thr  Cys Thr Gly 
    1070                 1075                 1080             


Thr Cys  Cys Cys Cys Gly Gly  Gly Cys Ala Ala Ala  Gly Gly Thr 
    1085                 1090                 1095             


Thr Cys  Ala Ala Cys Gly Thr  Cys Gly Gly Gly Thr  Gly Gly Cys 
    1100                 1105                 1110             


Gly Gly  Thr Thr Cys Cys Gly  Gly Cys Gly Gly Thr  Gly Gly Cys 
    1115                 1120                 1125             


Thr Cys  Ala Gly Gly Thr Gly  Gly Cys Gly Gly Thr  Gly Gly Cys 
    1130                 1135                 1140             


Ala Gly  Cys Thr Cys Thr Gly  Gly Cys Cys Ala Ala  Cys Cys Gly 
    1145                 1150                 1155             


Cys Gly  Cys Gly Ala Ala Cys  Cys Gly Cys Ala Gly  Gly Thr Thr 
    1160                 1165                 1170             


Thr Ala  Cys Ala Cys Cys Cys  Thr Gly Cys Cys Gly  Cys Cys Gly 
    1175                 1180                 1185             


Ala Gly  Cys Cys Gly Thr Gly  Ala Cys Gly Ala Ala  Cys Thr Gly 
    1190                 1195                 1200             


Ala Cys  Cys Ala Ala Ala Ala  Ala Cys Cys Ala Ala  Gly Thr Cys 
    1205                 1210                 1215             


Ala Gly  Cys Cys Thr Gly Ala  Cys Gly Thr Gly Cys  Cys Thr Gly 
    1220                 1225                 1230             


Gly Thr  Gly Ala Ala Ala Gly  Gly Cys Thr Thr Thr  Thr Ala Cys 
    1235                 1240                 1245             


Cys Cys  Gly Ala Gly Thr Gly  Ala Cys Ala Thr Thr  Gly Cys Ala 
    1250                 1255                 1260             


Gly Thr  Thr Gly Ala Ala Thr  Gly Gly Gly Ala Ala  Thr Cys Cys 
    1265                 1270                 1275             


Ala Ala  Thr Gly Gly Thr Cys  Ala Gly Cys Cys Gly  Gly Ala Ala 
    1280                 1285                 1290             


Ala Ala  Thr Ala Ala Cys Thr  Ala Cys Ala Ala Ala  Ala Cys Gly 
    1295                 1300                 1305             


Ala Cys  Gly Cys Cys Gly Cys  Cys Gly Gly Thr Thr  Cys Thr Gly 
    1310                 1315                 1320             


Gly Ala  Thr Thr Cys Ala Gly  Ala Cys Gly Gly Cys  Thr Cys Gly 
    1325                 1330                 1335             


Thr Thr  Thr Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Thr Cys Ala 
    1340                 1345                 1350             


Ala Ala  Ala Cys Thr Gly Ala  Cys Cys Gly Thr Cys  Gly Ala Thr 
    1355                 1360                 1365             


Ala Ala  Ala Thr Cys Gly Cys  Gly Cys Thr Gly Gly  Cys Ala Ala 
    1370                 1375                 1380             


Cys Ala  Gly Gly Gly Thr Ala  Ala Cys Gly Thr Thr  Thr Thr Cys 
    1385                 1390                 1395             


Ala Gly  Cys Thr Gly Cys Thr  Cys Thr Gly Thr Cys  Ala Thr Gly 
    1400                 1405                 1410             


Cys Ala  Cys Gly Ala Ala Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1415                 1420                 1425             


Ala Ala  Cys Cys Ala Thr Thr  Ala Thr Ala Cys Cys  Cys Ala Gly 
    1430                 1435                 1440             


Ala Ala  Ala Ala Gly Thr Cys  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1445                 1450                 1455             


Thr Cys  Ala Cys Cys Gly Gly  Gly Cys Ala Ala Ala  Gly Ala Ala 
    1460                 1465                 1470             


Gly Thr  Gly Cys Ala Gly Cys  Thr Gly Gly Thr Thr  Gly Ala Ala 
    1475                 1480                 1485             


Thr Cys  Thr Gly Gly Thr Gly  Gly Cys Gly Gly Thr  Cys Thr Gly 
    1490                 1495                 1500             


Gly Thr  Gly Cys Ala Ala Cys  Cys Gly Gly Gly Cys  Gly Gly Thr 
    1505                 1510                 1515             


Thr Cys  Gly Cys Thr Gly Cys  Gly Thr Cys Thr Gly  Ala Gly Cys 
    1520                 1525                 1530             


Thr Gly  Thr Gly Cys Ala Gly  Cys Thr Thr Cys Thr  Gly Gly Cys 
    1535                 1540                 1545             


Thr Thr  Thr Ala Ala Thr Ala  Thr Thr Ala Ala Ala  Gly Ala Cys 
    1550                 1555                 1560             


Ala Cys  Gly Thr Ala Cys Ala  Thr Cys Cys Ala Cys  Thr Gly Gly 
    1565                 1570                 1575             


Gly Thr  Gly Cys Gly Thr Cys  Ala Gly Gly Cys Ala  Cys Cys Gly 
    1580                 1585                 1590             


Gly Gly  Thr Ala Ala Ala Gly  Gly Cys Cys Thr Gly  Gly Ala Ala 
    1595                 1600                 1605             


Thr Gly  Gly Gly Thr Thr Gly  Cys Thr Cys Gly Thr  Ala Thr Cys 
    1610                 1615                 1620             


Thr Ala  Thr Cys Cys Gly Ala  Cys Gly Ala Ala Cys  Gly Gly Thr 
    1625                 1630                 1635             


Thr Ala  Thr Ala Cys Gly Cys  Gly Thr Thr Ala Cys  Gly Cys Cys 
    1640                 1645                 1650             


Gly Ala  Thr Ala Gly Cys Gly  Thr Cys Ala Ala Ala  Gly Gly Cys 
    1655                 1660                 1665             


Cys Gly  Thr Thr Thr Thr Ala  Cys Cys Ala Thr Cys  Ala Gly Thr 
    1670                 1675                 1680             


Gly Cys  Ala Gly Ala Cys Ala  Cys Cys Thr Cys Cys  Ala Ala Ala 
    1685                 1690                 1695             


Ala Ala  Cys Ala Cys Gly Gly  Cys Thr Thr Ala Thr  Cys Thr Gly 
    1700                 1705                 1710             


Cys Ala  Gly Ala Thr Gly Ala  Ala Thr Ala Gly Thr  Cys Thr Gly 
    1715                 1720                 1725             


Cys Gly  Thr Gly Cys Ala Gly  Ala Ala Gly Ala Thr  Ala Cys Cys 
    1730                 1735                 1740             


Gly Cys  Thr Gly Thr Thr Thr  Ala Thr Thr Ala Cys  Thr Gly Cys 
    1745                 1750                 1755             


Ala Gly  Cys Cys Gly Cys Thr  Gly Gly Gly Gly Cys  Gly Gly Thr 
    1760                 1765                 1770             


Gly Ala  Thr Gly Gly Cys Thr  Thr Cys Thr Ala Thr  Gly Cys Ala 
    1775                 1780                 1785             


Ala Thr  Gly Gly Ala Thr Thr  Ala Thr Thr Gly Gly  Gly Gly Thr 
    1790                 1795                 1800             


Cys Ala  Ala Gly Gly Thr Ala  Cys Cys Cys Thr Gly  Gly Thr Cys 
    1805                 1810                 1815             


Ala Cys  Cys Gly Thr Gly Ala  Gly Thr Thr Cys Cys  Gly Gly Thr 
    1820                 1825                 1830             


Thr Cys  Gly Ala Cys Cys Ala  Gly Cys Gly Gly Cys  Gly Gly Thr 
    1835                 1840                 1845             


Gly Gly  Cys Thr Cys Ala Gly  Gly Thr Gly Gly Cys  Gly Gly Thr 
    1850                 1855                 1860             


Thr Cys  Gly Gly Gly Cys Gly  Gly Thr Gly Gly Cys  Gly Gly Thr 
    1865                 1870                 1875             


Thr Cys  Ala Thr Cys Gly Gly  Ala Cys Ala Thr Thr  Cys Ala Gly 
    1880                 1885                 1890             


Ala Thr  Gly Ala Cys Gly Cys  Ala Ala Ala Gly Cys  Cys Cys Gly 
    1895                 1900                 1905             


Ala Gly  Cys Thr Cys Thr Cys  Thr Gly Thr Cys Thr  Gly Cys Gly 
    1910                 1915                 1920             


Ala Gly  Thr Gly Thr Thr Gly  Gly Cys Gly Ala Thr  Cys Gly Thr 
    1925                 1930                 1935             


Gly Thr  Cys Ala Cys Cys Ala  Thr Cys Ala Cys Gly  Thr Gly Thr 
    1940                 1945                 1950             


Cys Gly  Cys Gly Cys Cys Thr  Cys Thr Cys Ala Gly  Gly Ala Cys 
    1955                 1960                 1965             


Gly Thr  Gly Ala Ala Thr Ala  Cys Cys Gly Cys Ala  Gly Thr Thr 
    1970                 1975                 1980             


Gly Cys  Thr Thr Gly Gly Thr  Ala Cys Cys Ala Ala  Cys Ala Ala 
    1985                 1990                 1995             


Ala Ala  Ala Cys Cys Gly Gly  Gly Cys Ala Ala Ala  Gly Cys Ala 
    2000                 2005                 2010             


Cys Cys  Gly Ala Ala Ala Cys  Thr Gly Cys Thr Gly  Ala Thr Thr 
    2015                 2020                 2025             


Thr Ala  Cys Thr Cys Cys Gly  Cys Thr Thr Cys Ala  Thr Thr Cys 
    2030                 2035                 2040             


Cys Thr  Gly Thr Ala Cys Ala  Gly Cys Gly Gly Thr  Gly Thr Gly 
    2045                 2050                 2055             


Cys Cys  Gly Thr Cys Thr Cys  Gly Thr Thr Thr Thr  Thr Cys Gly 
    2060                 2065                 2070             


Gly Gly  Cys Ala Gly Cys Cys  Gly Cys Thr Cys Thr  Gly Gly Thr 
    2075                 2080                 2085             


Ala Cys  Cys Gly Ala Thr Thr  Thr Cys Ala Cys Cys  Cys Thr Gly 
    2090                 2095                 2100             


Ala Cys  Gly Ala Thr Thr Ala  Gly Thr Thr Cys Cys  Cys Thr Gly 
    2105                 2110                 2115             


Cys Ala  Ala Cys Cys Gly Gly  Ala Ala Gly Ala Thr  Thr Thr Cys 
    2120                 2125                 2130             


Gly Cys  Cys Ala Cys Cys Thr  Ala Cys Thr Ala Cys  Thr Gly Cys 
    2135                 2140                 2145             


Cys Ala  Gly Cys Ala Ala Cys  Ala Cys Thr Ala Thr  Ala Cys Gly 
    2150                 2155                 2160             


Ala Cys  Cys Cys Cys Gly Cys  Cys Gly Ala Cys Gly  Thr Thr Thr 
    2165                 2170                 2175             


Gly Gly  Thr Cys Ala Gly Gly  Gly Cys Ala Cys Gly  Ala Ala Ala 
    2180                 2185                 2190             


Gly Thr  Gly Gly Ala Ala Ala  Thr Thr Ala Ala Ala  Ala Ala Cys 
    2195                 2200                 2205             


Cys Gly  Thr Gly Thr Gly Cys  Gly Thr Cys Gly Cys  Ala Gly Cys 
    2210                 2215                 2220             


Ala Ala  Ala Cys Thr Gly Gly  Cys Gly Ala Ala Ala  Cys Thr Gly 
    2225                 2230                 2235             


Gly Cys  Cys Ala Ala Ala Ala  Ala Ala Cys Thr Gly  Gly Cys Ala 
    2240                 2245                 2250             


Ala Ala  Ala Cys Thr Gly Gly  Cys Thr Ala Ala Ala  Ala Ala Ala 
    2255                 2260                 2265             


Cys Thr  Gly Gly Cys Gly Ala  Ala Ala Thr Ala Ala  Thr Gly Ala 
    2270                 2275                 2280             


Ala Ala  Gly Cys Thr Thr 
    2285                 


<210>  63
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Mammalian humanized antibody

<400>  63
catatggaaa atctgtattt ccaaggtaaa tttgcgaaat tcgccaaaaa attcgcaaaa       60

ttcgcgaaaa aattcgcgaa agatattcaa atgacccagt ccccgagcag cctgagtgcc      120

tccgttggcg accgcgtgac cattacgtgc cgtgcgagcc aggatgtcaa caccgcggtg      180

gcctggtatc agcaaaaacc gggcaaagcg ccgaaactgc tgatctattc agcctcgttt      240

ctgtacagcg gtgttccgtc tcgtttcagc ggctctcgca gtggtaccga ttttaccctg      300

acgattagct ctctgcagcc ggaagacttt gcgacgtatt actgccagca acattacacc      360

acgccgccga ccttcggcca gggtacgaaa gtggaaatca aaggttccac ctcaggcggt      420

ggcagtggtg gcggttccgg cggtggcggt agttccgaag ttcagctggt cgaaagtggc      480

ggtggcctgg ttcaaccggg tggctcactg cgtctgtcgt gtgcagcaag cggtttcaac      540

atcaaagata cctacatcca ctgggttcgt caggcgccgg gcaaaggtct ggaatgggtc      600

gcccgcattt acccgaccaa tggctatacg cgttacgcag atagcgtgaa aggtcgcttt      660

accatctctg cggacaccag taaaaacacg gcctatctgc agatgaatag cctgcgtgcg      720

gaagatacgg ccgtttatta ctgctctcgc tggggtggcg atggcttcta tgctatggac      780

tactggggcc agggtaccct ggtgacggtt tcatcgggtc agccgcgtga accgcaagtg      840

tataccctgc cgccgtcacg cgatgaactg acgaaaaacc aggtgtcgct gacgtgtctg      900

gttaaaggct tttacccgag cgacatcgcg gttgaatggg aatctaatgg tcaaccggaa      960

aacaattata aaaccacgcc gccggtcctg gatagtgacg gctccttttt cctgtacagt     1020

aaactgaccg tggataaatc ccgttggcag cagggtaacg tcttctcgtg tagcgtgatg     1080

catgaagccc tgcataatca ctatacccag aaatctctga gtctgtcccc gggcaaaggt     1140

tcaacgtcgg gtggcggttc cggcggtggc tcaggtggcg gtggcagctc tggccaaccg     1200

cgcgaaccgc aggtttacac cctgccgccg agccgtgacg aactgaccaa aaaccaagtc     1260

agcctgacgt gcctggtgaa aggcttttac ccgagtgaca ttgcagttga atgggaatcc     1320

aatggtcagc cggaaaataa ctacaaaacg acgccgccgg ttctggattc agacggctcg     1380

tttttcctgt actcaaaact gaccgtcgat aaatcgcgct ggcaacaggg taacgttttc     1440

agctgctctg tcatgcacga agccctgcac aaccattata cccagaaaag tctgtccctg     1500

tcaccgggca aagaagtgca gctggttgaa tctggtggcg gtctggtgca accgggcggt     1560

tcgctgcgtc tgagctgtgc agcttctggc tttaatatta aagacacgta catccactgg     1620

gtgcgtcagg caccgggtaa aggcctggaa tgggttgctc gtatctatcc gacgaacggt     1680

tatacgcgtt acgccgatag cgtcaaaggc cgttttacca tcagtgcaga cacctccaaa     1740

aacacggctt atctgcagat gaatagtctg cgtgcagaag ataccgctgt ttattactgc     1800

agccgctggg gcggtgatgg cttctatgca atggattatt ggggtcaagg taccctggtc     1860

accgtgagtt ccggttcgac cagcggcggt ggctcaggtg gcggttcggg cggtggcggt     1920

tcatcggaca ttcagatgac gcaaagcccg agctctctgt ctgcgagtgt tggcgatcgt     1980

gtcaccatca cgtgtcgcgc ctctcaggac gtgaataccg cagttgcttg gtaccaacaa     2040

aaaccgggca aagcaccgaa actgctgatt tactccgctt cattcctgta cagcggtgtg     2100

ccgtctcgtt tttcgggcag ccgctctggt accgatttca ccctgacgat tagttccctg     2160

caaccggaag atttcgccac ctactactgc cagcaacact atacgacccc gccgacgttt     2220

ggtcagggca cgaaagtgga aattaaaaaa tttgcgaaat tcgccaaaaa attcgcaaaa     2280

ttcgcgaaaa aattcgcgaa ataatgaaag ctt                                  2313


<210>  64
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Recombinant anti-Her2 
       antibody

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                165                 170                 175     


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
    210                 215                 220                 


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                485                 490                 495     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            500                 505                 510         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        515                 520                 525             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    530                 535                 540                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
545                 550                 555                 560 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                565                 570                 575     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Cys 
            580                 585                 590         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        595                 600                 605             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    610                 615                 620                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
625                 630                 635                 640 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                645                 650                 655     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            660                 665                 670         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        675                 680                 685             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Glu 
    690                 695                 700                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
705                 710                 715                 720 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
                725                 730                 735     


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            740                 745                 750         


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
        755                 760                 765             


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
    770                 775                 780                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
785                 790                 795                 800 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                805                 810                 815     


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly 
            820                 825                 830         


Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Met Thr Gln Ser 
        835                 840                 845             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    850                 855                 860                 


Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys 
865                 870                 875                 880 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
                885                 890                 895     


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
            900                 905                 910         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        915                 920                 925             


Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
    930                 935                 940                 


Val Glu Ile Lys 
945             


<210>  65
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence:  Lytic peptide conjugate

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                165                 170                 175     


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
    210                 215                 220                 


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                485                 490                 495     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            500                 505                 510         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        515                 520                 525             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    530                 535                 540                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
545                 550                 555                 560 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                565                 570                 575     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Cys 
            580                 585                 590         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        595                 600                 605             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    610                 615                 620                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
625                 630                 635                 640 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                645                 650                 655     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            660                 665                 670         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        675                 680                 685             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Glu 
    690                 695                 700                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
705                 710                 715                 720 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
                725                 730                 735     


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            740                 745                 750         


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
        755                 760                 765             


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
    770                 775                 780                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
785                 790                 795                 800 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                805                 810                 815     


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly 
            820                 825                 830         


Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Met Thr Gln Ser 
        835                 840                 845             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    850                 855                 860                 


Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys 
865                 870                 875                 880 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
                885                 890                 895     


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
            900                 905                 910         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        915                 920                 925             


Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
    930                 935                 940                 


Val Glu Ile Lys Gly Ser Lys Phe Ala Lys Phe Ala Lys Lys Phe Ala 
945                 950                 955                 960 


Lys Phe Ala Lys Lys Phe Ala Lys 
                965             


