                         SEQUENCE LISTING

<110>  Universit Joseph Fourier
 
<120>  Utilisation de peptide comme transporteurs destins  
       l'internalisation de molcules d'intrt dans des cellules cibles

<130>  09 BH UJF ZEBR

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  51
<212>  PRT
<213>  Epstein Barr virus

<400>  1

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln 
    50      


<210>  2
<211>  298
<212>  PRT
<213>  Xenopus

<400>  2

Met Arg His Met Gln Ser Ala Thr Arg Ala Thr Leu Val Cys Gly Ser 
1               5                   10                  15      


Gly Val Lys Gln Ile Ile Ala Lys Gly His Pro Asn Thr Arg Val Phe 
            20                  25                  30          


Gly Ala Arg Lys Ala Arg Ile Pro Glu Arg Glu Val Leu Ala Ala Lys 
        35                  40                  45              


Pro Lys Ile Thr Arg Ile Thr His Leu Asn Leu Gln Pro Gln Glu Arg 
    50                  55                  60                  


Gln Ala Phe Tyr Arg Leu Leu Glu Asn Glu Leu Ile Gln Glu Phe Leu 
65                  70                  75                  80  


Ser Met Asp Ser Cys Leu Lys Ile Ser Asp Lys Tyr Leu Ile Ala Met 
                85                  90                  95      


Val Leu Ala Tyr Phe Lys Arg Ala Gly Leu Tyr Thr Gly Glu Tyr Thr 
            100                 105                 110         


Thr Met Asn Phe Phe Val Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu 
        115                 120                 125             


Asp Glu Glu Asp Tyr Lys Tyr Glu Ile Phe Pro Trp Ala Leu Gly Asp 
    130                 135                 140                 


Ser Trp Arg Glu Phe Phe Pro Gln Phe Leu Arg Leu Arg Asp Asn Phe 
145                 150                 155                 160 


Trp Ala Lys Met Asn Tyr Arg Ala Val Val Ser Arg Arg Cys Cys Asp 
                165                 170                 175     


Glu Val Met Ala Lys Asp Pro Thr His Trp Ala Trp Leu Arg Asp Arg 
            180                 185                 190         


Pro Ile His His Ser Gly Ala Leu Arg Gly Tyr Leu Arg Asn Glu Asp 
        195                 200                 205             


Asp Phe Phe Pro Arg Gly Pro Gly Leu Thr Pro Ala Ser Cys Ala Leu 
    210                 215                 220                 


Cys His Lys Ala Ser Val Cys Asp Ser Gly Gly Val Ala His Asp Asn 
225                 230                 235                 240 


Ser Ser Pro Glu Gln Glu Ile Phe His Tyr Thr Asn Arg Glu Trp Ser 
                245                 250                 255     


Gln Glu Leu Leu Ile Leu Pro Pro Glu Leu Leu Leu Asp Pro Glu Ser 
            260                 265                 270         


Thr Tyr Asp Ile His Ile Phe Gln Glu Pro Leu Val Gly Leu Glu Pro 
        275                 280                 285             


Asp Gly Ala Ala Leu Glu Trp His His Leu 
    290                 295             


<210>  3
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Glu Val Gln Ala Phe Leu Ser Leu Leu Glu Asp Ser Phe Val Gln 
1               5                   10                  15      


Glu Phe Leu Ser Lys Asp Pro Cys Phe Gln Ile Ser Asp Lys Tyr Leu 
            20                  25                  30          


Leu Ala Met Val Leu Val Tyr Phe Gln Arg Ala His Leu Lys Leu Ser 
        35                  40                  45              


Glu Tyr Thr His Ser Ser Leu Phe Leu Ala Leu Tyr Leu Ala Asn Asp 
    50                  55                  60                  


Met Glu Glu Asp Leu Glu Gly Pro Lys Cys Glu Ile Phe Pro Trp Ala 
65                  70                  75                  80  


Leu Gly Lys Asp Trp Cys Leu Arg Val Gly Lys Phe Leu His Gln Arg 
                85                  90                  95      


Asp Lys Leu Trp Ala Arg Met Gly Phe Arg Ala Val Val Ser Arg Gln 
            100                 105                 110         


Cys Cys Glu Glu Val Met Ala Lys Glu Pro Phe His Trp Ala Trp Thr 
        115                 120                 125             


Arg Asp Arg 
    130     


<210>  4
<211>  131
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Glu Met Thr Ala Phe Phe Lys Leu Phe Asp Asp Asp Leu Ile Gln 
1               5                   10                  15      


Asp Phe Leu Trp Met Asp Cys Cys Cys Lys Ile Ala Asp Lys Tyr Leu 
            20                  25                  30          


Leu Ala Met Thr Phe Val Tyr Phe Lys Arg Ala Lys Phe Thr Ile Asn 
        35                  40                  45              


Glu His Thr Arg Ile Asn Phe Phe Ile Ala Leu Tyr Leu Ala Asn Thr 
    50                  55                  60                  


Val Glu Glu Asp Glu Glu Glu Ala Lys Tyr Glu Ile Phe Pro Trp Ala 
65                  70                  75                  80  


Leu Gly Lys Asn Trp Arg Lys Leu Phe Pro Asn Phe Leu Lys Leu Arg 
                85                  90                  95      


Asp Gln Leu Trp Asp Arg Ile Asp Tyr Arg Ala Ile Val Ser Arg Arg 
            100                 105                 110         


Cys Cys Glu Glu Val Met Ala Ile Ala Pro Thr His Tyr Ile Trp Gln 
        115                 120                 125             


Arg Glu Arg 
    130     


<210>  5
<211>  133
<212>  PRT
<213>  Xenopus

<400>  5

Pro Gln Glu Arg Gln Ala Phe Tyr Arg Leu Leu Glu Asn Glu Leu Ile 
1               5                   10                  15      


Gln Glu Phe Leu Ser Met Asp Ser Cys Leu Lys Ile Ser Asp Lys Tyr 
            20                  25                  30          


Leu Ile Ala Met Val Leu Ala Tyr Phe Lys Arg Ala Gly Leu Tyr Thr 
        35                  40                  45              


Gly Glu Tyr Thr Thr Met Asn Phe Phe Val Ala Leu Tyr Leu Ala Asn 
    50                  55                  60                  


Asp Met Glu Glu Asp Glu Glu Asp Tyr Lys Tyr Glu Ile Phe Pro Trp 
65                  70                  75                  80  


Ala Leu Gly Asp Ser Trp Arg Glu Phe Phe Pro Gln Phe Leu Arg Leu 
                85                  90                  95      


Arg Asp Asn Phe Trp Ala Lys Met Asn Tyr Arg Ala Val Val Ser Arg 
            100                 105                 110         


Arg Cys Cys Asp Glu Val Met Ala Lys Asp Pro Thr His Trp Ala Trp 
        115                 120                 125             


Leu Arg Asp Arg Pro 
    130             


<210>  6
<211>  133
<212>  PRT
<213>  Xenopus

<400>  6

Pro Gln Glu Arg Gln Ala Phe Tyr Arg Leu Leu Glu Asn Glu Leu Ile 
1               5                   10                  15      


Gln Glu Phe Leu Ser Met Asp Ser Cys Leu Lys Ile Ser Asp Lys Tyr 
            20                  25                  30          


Leu Ile Ala Met Val Leu Ala Tyr Phe Lys Arg Ala Gly Leu Tyr Thr 
        35                  40                  45              


Gly Glu Tyr Thr Thr Met Asn Phe Phe Val Ala Leu Tyr Leu Ala Asn 
    50                  55                  60                  


Asp Met Glu Glu Asp Glu Glu Asp Tyr Lys Tyr Glu Ile Phe Pro Trp 
65                  70                  75                  80  


Ala Leu Gly Asp Ser Trp Arg Glu Phe Phe Pro Gln Phe Leu Arg Leu 
                85                  90                  95      


Arg Asp Asn Phe Trp Ala Lys Met Asn Tyr Arg Ala Val Val Ser Arg 
            100                 105                 110         


Arg Cys Cys Asp Glu Val Met Ala Lys Asp Pro Thr His Trp Ala Trp 
        115                 120                 125             


Leu Arg Asp Arg Pro 
    130             


<210>  7
<211>  131
<212>  PRT
<213>  Drosophila

<400>  7

Gln Glu Met Thr Ala Phe Phe Lys Leu Phe Asp Asp Asp Leu Ile Gln 
1               5                   10                  15      


Asp Phe Leu Trp Met Asp Cys Cys Cys Lys Ile Ala Asp Lys Tyr Leu 
            20                  25                  30          


Leu Ala Met Thr Phe Val Tyr Phe Lys Arg Ala Lys Phe Thr Ile Asn 
        35                  40                  45              


Glu His Thr Arg Ile Asn Phe Phe Ile Ala Leu Tyr Leu Ala Asn Thr 
    50                  55                  60                  


Val Glu Glu Asp Glu Glu Glu Ala Lys Tyr Glu Ile Phe Pro Trp Ala 
65                  70                  75                  80  


Leu Gly Lys Asn Trp Arg Lys Leu Phe Pro Asn Phe Leu Lys Leu Arg 
                85                  90                  95      


Asp Gln Leu Trp Asp Arg Ile Asp Tyr Arg Ala Ile Val Ser Arg Arg 
            100                 105                 110         


Cys Cys Glu Glu Val Met Ala Ile Ala Pro Thr His Tyr Ile Trp Gln 
        115                 120                 125             


Arg Glu Arg 
    130     


<210>  8
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(17)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(28)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (33)..(34)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (36)..(38)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (44)..(55)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (64)..(66)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (68)..(72)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (74)..(75)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  MISC_FEATURE
<222>  (78)..(81)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (84)..(93)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (95)..(97)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(110)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (114)..(115)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (119)..(128)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<220>
<221>  misc_feature
<222>  (133)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  X est choisi parmi A, R, N, D, C, E, S, Q, G, H, I, L, K, M, F, 
       P, S, T, W, Y, V,

<400>  8

Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Leu Phe Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Tyr 
            20                  25                  30          


Leu Xaa Xaa Met Xaa Xaa Xaa Tyr Phe Xaa Arg Ala Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Ala Leu Tyr Leu Ala Asn 
    50                  55                  60                  


Xaa Xaa Xaa Glu Asp Xaa Xaa Xaa Xaa Lys Xaa Ile Phe Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa 
                85                  90                  95      


Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Ser Arg 
            100                 105                 110         


Xaa Xaa Cys Xaa Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp 
        115                 120                 125             


Xaa Arg Xaa Arg Xaa 
    130             


<210>  9
<211>  411
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Pro Arg Glu Arg Lys Glu Arg Asp Ser Lys Asp His Ser Asn Met 
1               5                   10                  15      


Lys Glu Glu Gly Gly Ser Asp Leu Ser Val Arg Ser Arg Lys Arg Lys 
            20                  25                  30          


Ala Asn Val Ala Val Phe Leu Gln Asp Pro Asp Glu Glu Ile Ala Lys 
        35                  40                  45              


Ile Asp Lys Thr Val Lys Ser Gln Asp Ser Ser Gln Pro Trp Asp Asp 
    50                  55                  60                  


Asp Ser Ala Cys Val Asp Pro Cys Ser Phe Ile Pro Thr Pro Asn Lys 
65                  70                  75                  80  


Glu Glu Asp Asn Glu Leu Glu Tyr Pro Lys Thr Ala Phe Gln Pro Arg 
                85                  90                  95      


Lys Ile Arg Pro Pro Arg Ala Ser Pro Leu Pro Val Leu Asn Trp Gly 
            100                 105                 110         


Asn Arg Glu Glu Val Trp Arg Ile Met Leu Asn Lys Glu Lys Thr Tyr 
        115                 120                 125             


Leu Arg Asp Glu His Phe Leu Gln Arg His Pro Leu Leu Gln Ala Arg 
    130                 135                 140                 


Met Arg Ala Val Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr 
145                 150                 155                 160 


Lys Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg 
                165                 170                 175     


Tyr Met Ala Ser Gln Gln Asn Ile Ile Lys Thr Leu Leu Gln Leu Ile 
            180                 185                 190         


Gly Ile Ser Ala Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Pro 
        195                 200                 205             


Pro Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Gly 
    210                 215                 220                 


Asp Glu Ile Leu Thr Met Glu Leu Met Met Met Lys Ala Leu Lys Trp 
225                 230                 235                 240 


Arg Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Val Gln 
                245                 250                 255     


Val Ala Tyr Val Asn Asp Thr Gly Glu Val Leu Met Pro Gln Tyr Pro 
            260                 265                 270         


Gln Gln Val Phe Val Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu 
        275                 280                 285             


Asp Val Gly Cys Leu Glu Phe Pro Tyr Gly Val Leu Ala Ala Ser Ala 
    290                 295                 300                 


Leu Tyr His Phe Ser Ser Leu Glu Leu Met Gln Lys Val Ser Gly Tyr 
305                 310                 315                 320 


Gln Trp Cys Asp Ile Glu Lys Cys Val Lys Trp Met Val Pro Phe Ala 
                325                 330                 335     


Met Val Ile Arg Glu Met Gly Ser Ser Lys Leu Lys His Phe Arg Gly 
            340                 345                 350         


Val Pro Met Glu Asp Ser His Asn Ile Gln Thr His Thr Asn Ser Leu 
        355                 360                 365             


Asp Leu Leu Asp Lys Ala Gln Ala Lys Lys Ala Ile Leu Ser Glu Gln 
    370                 375                 380                 


Asn Arg Ile Ser Pro Pro Pro Ser Gly Val Leu Thr Pro Pro His Ser 
385                 390                 395                 400 


Ser Lys Lys Gln Ser Ser Glu Gln Glu Thr Glu 
                405                 410     


<210>  10
<211>  20
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Glu Leu Met Met Met Lys Ala Leu Lys Trp Arg Leu Ser Pro Leu Thr 
1               5                   10                  15      


Ile Val Ser Trp 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  11

Glu Leu Met Met Met Lys Ala Leu Lys Trp Arg Leu Ser Pro Leu Thr 
1               5                   10                  15      


Ile Val Ser Trp 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  12

Glu Leu Met Met Met Lys Ala Leu Lys Trp Arg Leu Ser Pro Leu Thr 
1               5                   10                  15      


Ile Val Ser Trp 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg Leu Ser Pro Leu Thr 
1               5                   10                  15      


Ile Val Ser Trp 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg Leu Ser Pro Leu Thr 
1               5                   10                  15      


Ile Val Ser Trp 
            20  


<210>  15
<211>  319
<212>  PRT
<213>  Mus musculus

<400>  15

Met Asp Leu Ser Ala Ile Tyr Glu Ser Leu Gln Ser Met Ser His Asp 
1               5                   10                  15      


Leu Ser Ser Asp His Gly Gly Thr Glu Ser Leu Gly Gly Leu Trp Asn 
            20                  25                  30          


Ile Asn Ser Asp Ser Ile Pro Ser Gly Val Thr Ser Arg Leu Thr Gly 
        35                  40                  45              


Arg Ser Thr Ser Leu Val Glu Gly Arg Ser Cys Gly Trp Val Pro Pro 
    50                  55                  60                  


Pro Pro Gly Phe Ala Pro Leu Ala Pro Arg Pro Gly Pro Glu Leu Ser 
65                  70                  75                  80  


Pro Ser Pro Thr Ser Pro Thr Ala Thr Pro Thr Thr Ser Ser Arg Tyr 
                85                  90                  95      


Lys Thr Glu Leu Cys Arg Thr Tyr Ser Glu Ser Gly Arg Cys Arg Tyr 
            100                 105                 110         


Gly Ala Lys Cys Gln Phe Ala His Gly Leu Gly Glu Leu Arg Gln Ala 
        115                 120                 125             


Asn Arg His Pro Lys Tyr Lys Thr Glu Leu Cys His Lys Phe Tyr Leu 
    130                 135                 140                 


Gln Gly Arg Cys Pro Tyr Gly Ser Arg Cys His Phe Ile His Asn Pro 
145                 150                 155                 160 


Thr Glu Asp Leu Ala Leu Pro Gly Gln Pro His Val Leu Arg Gln Ser 
                165                 170                 175     


Ile Ser Phe Ser Gly Leu Pro Ser Gly Arg Arg Ser Ser Pro Pro Pro 
            180                 185                 190         


Pro Gly Phe Ser Gly Pro Ser Leu Ser Ser Cys Ser Phe Ser Pro Ser 
        195                 200                 205             


Ser Ser Pro Pro Pro Pro Gly Asp Leu Pro Leu Ser Pro Ser Ala Phe 
    210                 215                 220                 


Ser Ala Ala Pro Gly Thr Pro Val Thr Arg Arg Asp Pro Asn Gln Ala 
225                 230                 235                 240 


Cys Cys Pro Ser Cys Arg Arg Ser Thr Thr Pro Ser Thr Ile Trp Gly 
                245                 250                 255     


Pro Leu Gly Gly Leu Ala Arg Ser Pro Ser Ala His Ser Leu Gly Ser 
            260                 265                 270         


Asp Pro Asp Asp Tyr Ala Ser Ser Gly Ser Ser Leu Gly Gly Ser Asp 
        275                 280                 285             


Ser Pro Val Phe Glu Ala Gly Val Phe Gly Pro Pro Gln Thr Pro Ala 
    290                 295                 300                 


Pro Pro Arg Arg Leu Pro Ile Phe Asn Arg Ile Ser Val Ser Glu 
305                 310                 315                 


<210>  16
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Leu Thr Ala Ile Tyr Glu Ser Leu Leu Ser Leu Ser Pro Asp 
1               5                   10                  15      


Val Pro Val Pro Ser Asp His Gly Gly Thr Glu Ser Ser Pro Gly Trp 
            20                  25                  30          


Gly Ser Ser Gly Pro Trp Ser Leu Ser Pro Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Gly Val Thr Ser Arg Leu Pro Gly Arg Ser Thr Ser Leu Val Glu Gly 
    50                  55                  60                  


Arg Ser Cys Gly Trp Val Pro Pro Pro Pro Gly Phe Ala Pro Leu Ala 
65                  70                  75                  80  


Pro Arg Leu Gly Pro Glu Leu Ser Pro Ser Pro Thr Ser Pro Thr Ala 
                85                  90                  95      


Thr Ser Thr Thr Pro Ser Arg Tyr Lys Thr Glu Leu Cys Arg Thr Phe 
            100                 105                 110         


Ser Glu Ser Gly Arg Cys Arg Tyr Gly Ala Lys Cys Gln Phe Ala His 
        115                 120                 125             


Gly Leu Gly Glu Leu Arg Gln Ala Asn Arg His Pro Lys Tyr Lys Thr 
    130                 135                 140                 


Glu Leu Cys His Lys Phe Tyr Leu Gln Gly Arg Cys Pro Tyr Gly Ser 
145                 150                 155                 160 


Arg Cys His Phe Ile His Asn Pro Ser Glu Asp Leu Ala Ala Pro Gly 
                165                 170                 175     


His Pro Pro Val Leu Arg Gln Ser Ile Ser Phe Ser Gly Leu Pro Ser 
            180                 185                 190         


Gly Arg Arg Thr Ser Pro Pro Pro Pro Gly Leu Ala Gly Pro Ser Leu 
        195                 200                 205             


Ser Ser Ser Ser Phe Ser Pro Ser Ser Ser Pro Pro Pro Pro Gly Asp 
    210                 215                 220                 


Leu Pro Leu Ser Pro Ser Ala Phe Ser Ala Ala Pro Gly Thr Pro Leu 
225                 230                 235                 240 


Ala Arg Arg Asp Pro Thr Pro Val Cys Cys Pro Ser Cys Arg Arg Ala 
                245                 250                 255     


Thr Pro Ile Ser Val Trp Gly Pro Leu Gly Gly Leu Val Arg Thr Pro 
            260                 265                 270         


Ser Val Gln Ser Leu Gly Ser Asp Pro Asp Glu Tyr Ala Ser Ser Gly 
        275                 280                 285             


Ser Ser Leu Gly Gly Ser Asp Ser Pro Val Phe Glu Ala Gly Val Phe 
    290                 295                 300                 


Ala Pro Pro Gln Pro Val Ala Ala Pro Arg Arg Leu Pro Ile Phe Asn 
305                 310                 315                 320 


Arg Ile Ser Val Ser Glu 
                325     


<210>  17
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Phe Leu Gly Gln Asp Trp Arg Ser Pro Gly Gln Asn Trp Val 
1               5                   10                  15      


Lys Thr Ala Asp Gly Trp Lys Arg Phe Leu Asp Glu Lys Ser Gly Ser 
            20                  25                  30          


Phe Val Ser Asp Leu Ser Ser Tyr Cys Asn Lys Glu Val Tyr Asn Lys 
        35                  40                  45              


Glu Asn Leu Phe Asn Ser Leu Asn Tyr Asp Val Ala Ala Lys Lys Arg 
    50                  55                  60                  


Lys Lys Asp Met Leu Asn Ser Lys Thr Lys Thr Gln Tyr Phe His Gln 
65                  70                  75                  80  


Glu Lys Trp Ile Tyr Val His Lys Gly Ser Thr Lys Glu Arg His Gly 
                85                  90                  95      


Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu Asp Phe Ser Thr Ala 
            100                 105                 110         


Ile Leu Asp Ser Arg Arg Phe Asn Tyr Val Val Arg Leu Leu Glu Leu 
        115                 120                 125             


Ile Ala Lys Ser Gln Leu Thr Ser Leu Ser Gly Ile Ala Gln Lys Asn 
    130                 135                 140                 


Phe Met Asn Ile Leu Glu Lys Val Val Leu Lys Val Leu Glu Asp Gln 
145                 150                 155                 160 


Gln Asn Ile Arg Leu Ile Arg Glu Leu Leu Gln Thr Leu Tyr Thr Ser 
                165                 170                 175     


Leu Cys Thr Leu Val Gln Arg Val Gly Lys Ser Val Leu Val Gly Asn 
            180                 185                 190         


Ile Asn Met Trp Val Tyr Arg Met Glu Thr Ile Leu His Trp Gln Gln 
        195                 200                 205             


Gln Leu Asn Asn Ile Gln Ile Thr Arg Pro Ala Phe Lys Gly Leu Thr 
    210                 215                 220                 


Phe Thr Asp Leu Pro Leu Cys Leu Gln Leu Asn Ile Met Gln Arg Leu 
225                 230                 235                 240 


Ser Asp Gly Arg Asp Leu Val Ser Leu Gly Gln Ala Ala Pro Asp Leu 
                245                 250                 255     


His Val Leu Ser Glu Asp Arg Leu Leu Trp Lys Lys Leu Cys Gln Tyr 
            260                 265                 270         


His Phe Ser Glu Arg Gln Ile Arg Lys Arg Leu Ile Leu Ser Asp Lys 
        275                 280                 285             


Gly Gln Leu Asp Trp Lys Lys Met Tyr Phe Lys Leu Val Arg Cys Tyr 
    290                 295                 300                 


Pro Arg Lys Glu Gln Tyr Gly Asp Thr Leu Gln Leu Cys Lys His Cys 
305                 310                 315                 320 


His Ile Leu Ser Trp Lys Gly Thr Asp His Pro Cys Thr Ala Asn Asn 
                325                 330                 335     


Pro Glu Ser Cys Ser Val Ser Leu Ser Pro Gln Asp Phe Ile Asn Leu 
            340                 345                 350         


Phe Lys Phe 
        355 


<210>  18
<211>  355
<212>  PRT
<213>  Mus musculus

<400>  18

Met Pro Phe Leu Gly Gln Asp Trp Arg Ser Pro Gly Gln Ser Trp Val 
1               5                   10                  15      


Lys Thr Ala Asp Gly Trp Lys Arg Phe Leu Asp Glu Lys Ser Gly Ser 
            20                  25                  30          


Phe Val Ser Asp Leu Ser Ser Tyr Cys Asn Lys Glu Val Tyr Ser Lys 
        35                  40                  45              


Glu Asn Leu Phe Ser Ser Leu Asn Tyr Asp Val Ala Ala Lys Lys Arg 
    50                  55                  60                  


Lys Lys Asp Ile Gln Asn Ser Lys Thr Lys Thr Gln Tyr Phe His Gln 
65                  70                  75                  80  


Glu Lys Trp Ile Tyr Val His Lys Gly Ser Thr Lys Glu Arg His Gly 
                85                  90                  95      


Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu Asp Phe Ser Thr Ala 
            100                 105                 110         


Ile Leu Asp Ser Arg Arg Phe Asn Tyr Val Val Arg Leu Leu Glu Leu 
        115                 120                 125             


Ile Ala Lys Ser Gln Leu Thr Ser Leu Ser Gly Ile Ala Gln Lys Asn 
    130                 135                 140                 


Phe Met Asn Ile Leu Glu Lys Val Val Leu Lys Val Leu Glu Asp Gln 
145                 150                 155                 160 


Gln Asn Ile Arg Leu Ile Arg Glu Leu Leu Gln Thr Leu Tyr Thr Ser 
                165                 170                 175     


Leu Cys Thr Leu Val Gln Arg Val Gly Lys Ser Val Leu Val Gly Asn 
            180                 185                 190         


Ile Asn Met Trp Val Tyr Arg Met Glu Thr Ile Leu His Trp Gln Gln 
        195                 200                 205             


Gln Leu Asn Ser Ile Gln Ile Ser Arg Pro Ala Phe Lys Gly Leu Thr 
    210                 215                 220                 


Ile Thr Asp Leu Pro Val Cys Leu Gln Leu Asn Ile Met Gln Arg Leu 
225                 230                 235                 240 


Ser Asp Gly Arg Asp Leu Val Ser Leu Gly Gln Ala Ala Pro Asp Leu 
                245                 250                 255     


His Val Leu Ser Glu Asp Arg Leu Leu Trp Lys Arg Leu Cys Gln Tyr 
            260                 265                 270         


His Phe Ser Glu Arg Gln Ile Arg Lys Arg Leu Ile Leu Ser Asp Lys 
        275                 280                 285             


Gly Gln Leu Asp Trp Lys Lys Met Tyr Phe Lys Leu Val Arg Cys Tyr 
    290                 295                 300                 


Pro Arg Arg Glu Gln Tyr Gly Val Thr Leu Gln Leu Cys Lys His Cys 
305                 310                 315                 320 


His Ile Leu Ser Trp Lys Gly Thr Asp His Pro Cys Thr Ala Asn Asn 
                325                 330                 335     


Pro Glu Ser Cys Ser Val Ser Leu Ser Pro Gln Asp Phe Ile Asn Leu 
            340                 345                 350         


Phe Lys Phe 
        355 


<210>  19
<211>  361
<212>  PRT
<213>  Mus musculus

<400>  19

Met Ala Ser Pro Ala Val Pro Ala Asn Val Pro Pro Ala Thr Ala Ala 
1               5                   10                  15      


Ala Ala Pro Ala Pro Val Val Thr Ala Ala Pro Ala Ser Ala Pro Thr 
            20                  25                  30          


Pro Ser Thr Pro Ala Pro Thr Pro Ala Ala Thr Pro Ala Ala Ser Pro 
        35                  40                  45              


Ala Pro Val Ser Ser Asp Pro Ala Val Ala Ala Pro Ala Ala Pro Gly 
    50                  55                  60                  


Gln Thr Pro Ala Ser Ala Pro Ala Pro Ala Gln Thr Pro Ala Pro Ser 
65                  70                  75                  80  


Gln Pro Gly Pro Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val 
                85                  90                  95      


Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg 
            100                 105                 110         


Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val 
        115                 120                 125             


Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Pro His Asn 
    130                 135                 140                 


Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn Met 
145                 150                 155                 160 


Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp 
                165                 170                 175     


Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val Leu Ile His Glu 
            180                 185                 190         


Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr 
        195                 200                 205             


Gly Leu Gln His Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu 
    210                 215                 220                 


Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr 
225                 230                 235                 240 


Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile 
                245                 250                 255     


Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp 
            260                 265                 270         


Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser 
        275                 280                 285             


Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala 
    290                 295                 300                 


Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro 
305                 310                 315                 320 


Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn 
                325                 330                 335     


Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile 
            340                 345                 350         


Ala Leu Asn Glu Lys Leu Val Asn Leu 
        355                 360     


<210>  20
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Gln Thr Pro Ala Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro 
1               5                   10                  15      


Ala Leu Pro Gly Pro Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val 
            20                  25                  30          


Val Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu 
        35                  40                  45              


Arg Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr 
    50                  55                  60                  


Val Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Pro His 
65                  70                  75                  80  


Asn Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn 
                85                  90                  95      


Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly 
            100                 105                 110         


Trp Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val Leu Ile His 
        115                 120                 125             


Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp 
    130                 135                 140                 


Thr Ser Leu Gln Asn Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr 
145                 150                 155                 160 


Leu Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu 
                165                 170                 175     


Thr Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu 
            180                 185                 190         


Ile Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser 
        195                 200                 205             


Asp Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu 
    210                 215                 220                 


Ser Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser 
225                 230                 235                 240 


Ala Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val 
                245                 250                 255     


Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile 
            260                 265                 270         


Asn Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln 
        275                 280                 285             


Ile Ala Leu Asn Glu Lys Leu Val Asn Leu 
    290                 295             


<210>  21
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Arg Pro 
1               5                   10                  15      


Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val Val 
            20                  25                  30          


Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser Gly 
        35                  40                  45              


Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val 
    50                  55                  60                  


Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met 
65                  70                  75                  80  


Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val 
                85                  90                  95      


Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu 
            100                 105                 110         


Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr 
        115                 120                 125             


Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe 
    130                 135                 140                 


Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe 
145                 150                 155                 160 


Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala 
                165                 170                 175     


Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu 
            180                 185                 190         


Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205     


<210>  22
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  22

Trp Asn Gln Val Pro Gly Leu Glu Gly Gln Glu Phe Arg Phe Gly Ser 
1               5                   10                  15      


Cys Gln Val Thr Gly Val Val Leu Pro Glu Leu Trp Glu Ala Phe Trp 
            20                  25                  30          


Thr Val Lys Asn Thr Val Gln Thr Gln Asp Asp Ile Thr Ser Ile Arg 
        35                  40                  45              


Leu Leu Lys Pro Gln Val Leu Arg Asn Val Ser Gly Ala Glu Ser Cys 
    50                  55                  60                  


Tyr Leu Ala His Ser Leu Leu Lys Phe Tyr Leu Asn Thr Val Phe Lys 
65                  70                  75                  80  


Asn Tyr His Ser Lys Ile Ala Lys Phe Lys Val Leu Arg Ser Phe Ser 
                85                  90                  95      


Thr Leu Ala Asn Asn Phe Ile Val Ile Met Ser Gln Leu Gln Pro Ser 
            100                 105                 110         


Lys Asp Asn Ser Met Leu Pro Ile Ser Glu Ser Ala His Gln Arg Phe 
        115                 120                 125             


Leu Leu Phe Arg Arg Ala Phe Lys Gln Leu Asp Thr Glu Val Ala Leu 
    130                 135                 140                 


Val Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys 
145                 150                 155                 160 


Phe Tyr His Leu 
                


<210>  23
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Gln Glu Asn Glu Met Phe Ser Ile Arg Asp 
            100                 105                 110         


Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala Phe Lys Gln Leu 
        115                 120                 125             


Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu Val Asp Ile Leu 
    130                 135                 140                 


Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
145                 150                 


<210>  24
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (5)..(5)
<223>  la tyrosine Y685 est phosphoryle par la src kinase

<400>  25

Arg Pro Ser Leu Tyr Ala Gln Val Gln 
1               5                   


<210>  26
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  27
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


<210>  28
<211>  200
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  28

Met His His His His His His His His Lys Arg Tyr Lys Asn Arg Val 
1               5                   10                  15      


Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr 
            20                  25                  30          


Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 
        35                  40                  45              


Leu Leu Lys Gln Met Cys Lys Leu Ala Lys Phe Val Ala Ala Trp Thr 
    50                  55                  60                  


Leu Lys Ala Ala Ala Gly Ser Asp Glu Val Ser Gly Leu Glu Gln Leu 
65                  70                  75                  80  


Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr Ser Ser Asn 
                85                  90                  95      


Val Met Glu Glu Arg Lys Ile Lys Val Tyr Leu Pro Arg Met Lys Met 
            100                 105                 110         


Glu Glu Lys Tyr Asn Leu Thr Ser Val Leu Met Ala Met Gly Ile Thr 
        115                 120                 125             


Asp Val Phe Ser Ser Ser Ala Asn Leu Ser Gly Ile Ser Ser Ala Glu 
    130                 135                 140                 


Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn 
145                 150                 155                 160 


Glu Ala Gly Arg Glu Val Val Gly Ser Ala Glu Ala Gly Val Asp Ala 
                165                 170                 175     


Ala Ser Val Ser Glu Glu Phe Arg Ala Asp His Pro Phe Leu Phe Cys 
            180                 185                 190         


Ile Lys His Ile Ala Thr Asn Ala 
        195                 200 


<210>  29
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  29

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Arg His Met Gln Ser Ala Thr Arg Ala Thr Leu Val 
    50                  55                  60                  


Cys Gly Ser Gly Val Lys Gln Ile Ile Ala Lys Gly His Pro Asn Thr 
65                  70                  75                  80  


Arg Val Phe Gly Ala Arg Lys Ala Arg Ile Pro Glu Arg Glu Val Leu 
                85                  90                  95      


Ala Ala Lys Pro Lys Ile Thr Arg Ile Thr His Leu Asn Leu Gln Pro 
            100                 105                 110         


Gln Glu Arg Gln Ala Phe Tyr Arg Leu Leu Glu Asn Glu Leu Ile Gln 
        115                 120                 125             


Glu Phe Leu Ser Met Asp Ser Cys Leu Lys Ile Ser Asp Lys Tyr Leu 
    130                 135                 140                 


Ile Ala Met Val Leu Ala Tyr Phe Lys Arg Ala Gly Leu Tyr Thr Gly 
145                 150                 155                 160 


Glu Tyr Thr Thr Met Asn Phe Phe Val Ala Leu Tyr Leu Ala Asn Asp 
                165                 170                 175     


Met Glu Glu Asp Glu Glu Asp Tyr Lys Tyr Glu Ile Phe Pro Trp Ala 
            180                 185                 190         


Leu Gly Asp Ser Trp Arg Glu Phe Phe Pro Gln Phe Leu Arg Leu Arg 
        195                 200                 205             


Asp Asn Phe Trp Ala Lys Met Asn Tyr Arg Ala Val Val Ser Arg Arg 
    210                 215                 220                 


Cys Cys Asp Glu Val Met Ala Lys Asp Pro Thr His Trp Ala Trp Leu 
225                 230                 235                 240 


Arg Asp Arg Pro Ile His His Ser Gly Ala Leu Arg Gly Tyr Leu Arg 
                245                 250                 255     


Asn Glu Asp Asp Phe Phe Pro Arg Gly Pro Gly Leu Thr Pro Ala Ser 
            260                 265                 270         


Cys Ala Leu Cys His Lys Ala Ser Val Cys Asp Ser Gly Gly Val Ala 
        275                 280                 285             


His Asp Asn Ser Ser Pro Glu Gln Glu Ile Phe His Tyr Thr Asn Arg 
    290                 295                 300                 


Glu Trp Ser Gln Glu Leu Leu Ile Leu Pro Pro Glu Leu Leu Leu Asp 
305                 310                 315                 320 


Pro Glu Ser Thr Tyr Asp Ile His Ile Phe Gln Glu Pro Leu Val Gly 
                325                 330                 335     


Leu Glu Pro Asp Gly Ala Ala Leu Glu Trp His His Leu 
            340                 345                 


<210>  30
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  30

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Gln Glu Val Gln Ala Phe Leu Ser Leu Leu Glu Asp Ser 
    50                  55                  60                  


Phe Val Gln Glu Phe Leu Ser Lys Asp Pro Cys Phe Gln Ile Ser Asp 
65                  70                  75                  80  


Lys Tyr Leu Leu Ala Met Val Leu Val Tyr Phe Gln Arg Ala His Leu 
                85                  90                  95      


Lys Leu Ser Glu Tyr Thr His Ser Ser Leu Phe Leu Ala Leu Tyr Leu 
            100                 105                 110         


Ala Asn Asp Met Glu Glu Asp Leu Glu Gly Pro Lys Cys Glu Ile Phe 
        115                 120                 125             


Pro Trp Ala Leu Gly Lys Asp Trp Cys Leu Arg Val Gly Lys Phe Leu 
    130                 135                 140                 


His Gln Arg Asp Lys Leu Trp Ala Arg Met Gly Phe Arg Ala Val Val 
145                 150                 155                 160 


Ser Arg Gln Cys Cys Glu Glu Val Met Ala Lys Glu Pro Phe His Trp 
                165                 170                 175     


Ala Trp Thr Arg Asp Arg 
            180         


<210>  31
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  31

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Pro Arg Glu Arg Lys Glu Arg Asp Ser Lys Asp His 
    50                  55                  60                  


Ser Asn Met Lys Glu Glu Gly Gly Ser Asp Leu Ser Val Arg Ser Arg 
65                  70                  75                  80  


Lys Arg Lys Ala Asn Val Ala Val Phe Leu Gln Asp Pro Asp Glu Glu 
                85                  90                  95      


Ile Ala Lys Ile Asp Lys Thr Val Lys Ser Gln Asp Ser Ser Gln Pro 
            100                 105                 110         


Trp Asp Asp Asp Ser Ala Cys Val Asp Pro Cys Ser Phe Ile Pro Thr 
        115                 120                 125             


Pro Asn Lys Glu Glu Asp Asn Glu Leu Glu Tyr Pro Lys Thr Ala Phe 
    130                 135                 140                 


Gln Pro Arg Lys Ile Arg Pro Pro Arg Ala Ser Pro Leu Pro Val Leu 
145                 150                 155                 160 


Asn Trp Gly Asn Arg Glu Glu Val Trp Arg Ile Met Leu Asn Lys Glu 
                165                 170                 175     


Lys Thr Tyr Leu Arg Asp Glu His Phe Leu Gln Arg His Pro Leu Leu 
            180                 185                 190         


Gln Ala Arg Met Arg Ala Val Leu Leu Asp Trp Leu Met Glu Val Cys 
        195                 200                 205             


Glu Val Tyr Lys Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe 
    210                 215                 220                 


Phe Asp Arg Tyr Met Ala Ser Gln Gln Asn Ile Ile Lys Thr Leu Leu 
225                 230                 235                 240 


Gln Leu Ile Gly Ile Ser Ala Leu Phe Ile Ala Ser Lys Leu Glu Glu 
                245                 250                 255     


Ile Tyr Pro Pro Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala 
            260                 265                 270         


Cys Ser Gly Asp Glu Ile Leu Thr Met Glu Leu Met Met Met Lys Ala 
        275                 280                 285             


Leu Lys Trp Arg Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val 
    290                 295                 300                 


Tyr Val Gln Val Ala Tyr Val Asn Asp Thr Gly Glu Val Leu Met Pro 
305                 310                 315                 320 


Gln Tyr Pro Gln Gln Val Phe Val Gln Ile Ala Glu Leu Leu Asp Leu 
                325                 330                 335     


Cys Val Leu Asp Val Gly Cys Leu Glu Phe Pro Tyr Gly Val Leu Ala 
            340                 345                 350         


Ala Ser Ala Leu Tyr His Phe Ser Ser Leu Glu Leu Met Gln Lys Val 
        355                 360                 365             


Ser Gly Tyr Gln Trp Cys Asp Ile Glu Lys Cys Val Lys Trp Met Val 
    370                 375                 380                 


Pro Phe Ala Met Val Ile Arg Glu Met Gly Ser Ser Lys Leu Lys His 
385                 390                 395                 400 


Phe Arg Gly Val Pro Met Glu Asp Ser His Asn Ile Gln Thr His Thr 
                405                 410                 415     


Asn Ser Leu Asp Leu Leu Asp Lys Ala Gln Ala Lys Lys Ala Ile Leu 
            420                 425                 430         


Ser Glu Gln Asn Arg Ile Ser Pro Pro Pro Ser Gly Val Leu Thr Pro 
        435                 440                 445             


Pro His Ser Ser Lys Lys Gln Ser Ser Glu Gln Glu Thr Glu 
    450                 455                 460         


<210>  32
<211>  71
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  32

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg Leu Ser 
    50                  55                  60                  


Pro Leu Thr Ile Val Ser Trp 
65                  70      


<210>  33
<211>  377
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  33

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Asp Leu Thr Ala Ile Tyr Glu Ser Leu Leu Ser Leu 
    50                  55                  60                  


Ser Pro Asp Val Pro Val Pro Ser Asp His Gly Gly Thr Glu Ser Ser 
65                  70                  75                  80  


Pro Gly Trp Gly Ser Ser Gly Pro Trp Ser Leu Ser Pro Ser Asp Ser 
                85                  90                  95      


Ser Pro Ser Gly Val Thr Ser Arg Leu Pro Gly Arg Ser Thr Ser Leu 
            100                 105                 110         


Val Glu Gly Arg Ser Cys Gly Trp Val Pro Pro Pro Pro Gly Phe Ala 
        115                 120                 125             


Pro Leu Ala Pro Arg Leu Gly Pro Glu Leu Ser Pro Ser Pro Thr Ser 
    130                 135                 140                 


Pro Thr Ala Thr Ser Thr Thr Pro Ser Arg Tyr Lys Thr Glu Leu Cys 
145                 150                 155                 160 


Arg Thr Phe Ser Glu Ser Gly Arg Cys Arg Tyr Gly Ala Lys Cys Gln 
                165                 170                 175     


Phe Ala His Gly Leu Gly Glu Leu Arg Gln Ala Asn Arg His Pro Lys 
            180                 185                 190         


Tyr Lys Thr Glu Leu Cys His Lys Phe Tyr Leu Gln Gly Arg Cys Pro 
        195                 200                 205             


Tyr Gly Ser Arg Cys His Phe Ile His Asn Pro Ser Glu Asp Leu Ala 
    210                 215                 220                 


Ala Pro Gly His Pro Pro Val Leu Arg Gln Ser Ile Ser Phe Ser Gly 
225                 230                 235                 240 


Leu Pro Ser Gly Arg Arg Thr Ser Pro Pro Pro Pro Gly Leu Ala Gly 
                245                 250                 255     


Pro Ser Leu Ser Ser Ser Ser Phe Ser Pro Ser Ser Ser Pro Pro Pro 
            260                 265                 270         


Pro Gly Asp Leu Pro Leu Ser Pro Ser Ala Phe Ser Ala Ala Pro Gly 
        275                 280                 285             


Thr Pro Leu Ala Arg Arg Asp Pro Thr Pro Val Cys Cys Pro Ser Cys 
    290                 295                 300                 


Arg Arg Ala Thr Pro Ile Ser Val Trp Gly Pro Leu Gly Gly Leu Val 
305                 310                 315                 320 


Arg Thr Pro Ser Val Gln Ser Leu Gly Ser Asp Pro Asp Glu Tyr Ala 
                325                 330                 335     


Ser Ser Gly Ser Ser Leu Gly Gly Ser Asp Ser Pro Val Phe Glu Ala 
            340                 345                 350         


Gly Val Phe Ala Pro Pro Gln Pro Val Ala Ala Pro Arg Arg Leu Pro 
        355                 360                 365             


Ile Phe Asn Arg Ile Ser Val Ser Glu 
    370                 375         


<210>  34
<211>  406
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  34

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Pro Phe Leu Gly Gln Asp Trp Arg Ser Pro Gly Gln 
    50                  55                  60                  


Asn Trp Val Lys Thr Ala Asp Gly Trp Lys Arg Phe Leu Asp Glu Lys 
65                  70                  75                  80  


Ser Gly Ser Phe Val Ser Asp Leu Ser Ser Tyr Cys Asn Lys Glu Val 
                85                  90                  95      


Tyr Asn Lys Glu Asn Leu Phe Asn Ser Leu Asn Tyr Asp Val Ala Ala 
            100                 105                 110         


Lys Lys Arg Lys Lys Asp Met Leu Asn Ser Lys Thr Lys Thr Gln Tyr 
        115                 120                 125             


Phe His Gln Glu Lys Trp Ile Tyr Val His Lys Gly Ser Thr Lys Glu 
    130                 135                 140                 


Arg His Gly Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu Asp Phe 
145                 150                 155                 160 


Ser Thr Ala Ile Leu Asp Ser Arg Arg Phe Asn Tyr Val Val Arg Leu 
                165                 170                 175     


Leu Glu Leu Ile Ala Lys Ser Gln Leu Thr Ser Leu Ser Gly Ile Ala 
            180                 185                 190         


Gln Lys Asn Phe Met Asn Ile Leu Glu Lys Val Val Leu Lys Val Leu 
        195                 200                 205             


Glu Asp Gln Gln Asn Ile Arg Leu Ile Arg Glu Leu Leu Gln Thr Leu 
    210                 215                 220                 


Tyr Thr Ser Leu Cys Thr Leu Val Gln Arg Val Gly Lys Ser Val Leu 
225                 230                 235                 240 


Val Gly Asn Ile Asn Met Trp Val Tyr Arg Met Glu Thr Ile Leu His 
                245                 250                 255     


Trp Gln Gln Gln Leu Asn Asn Ile Gln Ile Thr Arg Pro Ala Phe Lys 
            260                 265                 270         


Gly Leu Thr Phe Thr Asp Leu Pro Leu Cys Leu Gln Leu Asn Ile Met 
        275                 280                 285             


Gln Arg Leu Ser Asp Gly Arg Asp Leu Val Ser Leu Gly Gln Ala Ala 
    290                 295                 300                 


Pro Asp Leu His Val Leu Ser Glu Asp Arg Leu Leu Trp Lys Lys Leu 
305                 310                 315                 320 


Cys Gln Tyr His Phe Ser Glu Arg Gln Ile Arg Lys Arg Leu Ile Leu 
                325                 330                 335     


Ser Asp Lys Gly Gln Leu Asp Trp Lys Lys Met Tyr Phe Lys Leu Val 
            340                 345                 350         


Arg Cys Tyr Pro Arg Lys Glu Gln Tyr Gly Asp Thr Leu Gln Leu Cys 
        355                 360                 365             


Lys His Cys His Ile Leu Ser Trp Lys Gly Thr Asp His Pro Cys Thr 
    370                 375                 380                 


Ala Asn Asn Pro Glu Ser Cys Ser Val Ser Leu Ser Pro Gln Asp Phe 
385                 390                 395                 400 


Ile Asn Leu Phe Lys Phe 
                405     


<210>  35
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  35

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Gly Gln Thr Pro Ala Ser Ala Gln Ala Pro Ala Gln Thr 
    50                  55                  60                  


Pro Ala Pro Ala Leu Pro Gly Pro Ala Leu Pro Gly Pro Phe Pro Gly 
65                  70                  75                  80  


Gly Arg Val Val Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp 
                85                  90                  95      


Ser Tyr Glu Arg Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu 
            100                 105                 110         


Leu Gly Thr Val Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser 
        115                 120                 125             


Val Pro His Asn Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe 
    130                 135                 140                 


Ala Lys Asn Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu 
145                 150                 155                 160 


Ile Leu Gly Trp Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val 
                165                 170                 175     


Leu Ile His Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu 
            180                 185                 190         


Thr Val Asp Thr Ser Leu Gln Asn Gly Arg Met Ser Ile Lys Ala Tyr 
        195                 200                 205             


Val Ser Thr Leu Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe 
    210                 215                 220                 


Thr Pro Leu Thr Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly 
225                 230                 235                 240 


Val Asp Leu Ile Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly 
                245                 250                 255     


Leu Ser Ser Asp Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln 
            260                 265                 270         


Asp Ala Leu Ser Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly 
        275                 280                 285             


Lys Val Ser Ala Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val 
    290                 295                 300                 


Asn Gln Val Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn 
305                 310                 315                 320 


Ser Asn Ile Asn Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr 
                325                 330                 335     


Gln Ser Gln Ile Ala Leu Asn Glu Lys Leu Val Asn Leu 
            340                 345                 


<210>  36
<211>  257
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  36

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu 
    50                  55                  60                  


Ala Arg Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln 
65                  70                  75                  80  


Met Val Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln 
                85                  90                  95      


Val Ser Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val 
            100                 105                 110         


Lys Gly Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys 
        115                 120                 125             


Asp Thr Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln 
    130                 135                 140                 


Gln Glu Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val 
145                 150                 155                 160 


His Thr Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His 
                165                 170                 175     


Asn Arg Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala 
            180                 185                 190         


Asn Asn Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn 
        195                 200                 205             


Glu Met Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe 
    210                 215                 220                 


Arg Arg Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala 
225                 230                 235                 240 


Leu Gly Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys 
                245                 250                 255     


Leu 
    


<210>  37
<211>  835
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  37

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala 
    50                  55                  60                  


Cys Leu Gly Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn 
65                  70                  75                  80  


Pro Ala Gln Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln 
                85                  90                  95      


Lys Arg Asp Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn 
            100                 105                 110         


Thr Ser Leu Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg 
        115                 120                 125             


Lys Asn Ala Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe 
    130                 135                 140                 


Arg Val Asp Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp 
145                 150                 155                 160 


Arg Glu Asn Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys 
                165                 170                 175     


Asp Thr Gly Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val 
            180                 185                 190         


His Asp Val Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn 
        195                 200                 205             


Ala Ser Val Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val 
    210                 215                 220                 


Thr Ala Val Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val 
225                 230                 235                 240 


Met Tyr Gln Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser 
                245                 250                 255     


Gly Arg Ile Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala 
            260                 265                 270         


Arg Tyr Glu Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly 
        275                 280                 285             


Asp Ser Gly Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp 
    290                 295                 300                 


Asn Phe Pro Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu 
305                 310                 315                 320 


Asp Thr Arg Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro 
                325                 330                 335     


Asp Glu Pro Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp 
            340                 345                 350         


Tyr Gln Asp Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly 
        355                 360                 365             


Ile Ile Lys Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr 
    370                 375                 380                 


Ser Phe Ile Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met 
385                 390                 395                 400 


Ser Pro Pro Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp 
                405                 410                 415     


Val Asp Glu Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu 
            420                 425                 430         


Lys Glu Asn Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp 
        435                 440                 445             


Pro Asp Ala Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser 
    450                 455                 460                 


Asp Lys Gly Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn 
465                 470                 475                 480 


Glu Lys Glu Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val 
                485                 490                 495     


Glu Ala Lys Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser 
            500                 505                 510         


Ile Val Gln Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro 
        515                 520                 525             


Glu Phe Ala Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His 
    530                 535                 540                 


Gly Gln Leu Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro 
545                 550                 555                 560 


Arg Asn Val Lys Phe Lys Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr 
                565                 570                 575     


Leu Thr Asp Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly 
            580                 585                 590         


Gln Phe Asp Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile 
        595                 600                 605             


Ser Asp Asn Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val 
    610                 615                 620                 


Ala Val Cys Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp 
625                 630                 635                 640 


Met Ala Ala Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu 
                645                 650                 655     


Leu Cys Ile Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg 
            660                 665                 670         


Arg Arg Leu Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu 
        675                 680                 685             


Ile His Glu Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met 
    690                 695                 700                 


Asp Thr Thr Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly 
705                 710                 715                 720 


Gly Ala Lys Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr 
                725                 730                 735     


Ala Gln Val Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly 
            740                 745                 750         


Pro Gly Glu Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp 
        755                 760                 765             


His Asp Gly Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr 
    770                 775                 780                 


Glu Gly Ser Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp 
785                 790                 795                 800 


Ser Ser Asp Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro 
                805                 810                 815     


Arg Phe Lys Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu 
            820                 825                 830         


Leu Leu Tyr 
        835 


<210>  38
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine


<220>
<221>  SITE
<222>  (56)..(56)
<223>  la tyrosine Y56 est phosphoryle par la src kinase

<400>  38

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Arg Pro Ser Leu Tyr Ala Gln Val Gln 
    50                  55                  60  


<210>  39
<211>  444
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  39

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro 
    50                  55                  60                  


Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
65                  70                  75                  80  


Asn Val Leu Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu 
                85                  90                  95      


Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp 
            100                 105                 110         


Glu Ala Pro Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro 
        115                 120                 125             


Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu 
    130                 135                 140                 


Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe 
145                 150                 155                 160 


Arg Leu Gly Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr 
                165                 170                 175     


Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys 
            180                 185                 190         


Pro Val Gln Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val 
        195                 200                 205             


Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val 
    210                 215                 220                 


Arg Arg Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala 
225                 230                 235                 240 


Pro Pro Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr 
                245                 250                 255     


Leu Asp Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu 
            260                 265                 270         


Pro Pro Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met 
        275                 280                 285             


Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr 
    290                 295                 300                 


Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser 
305                 310                 315                 320 


Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu 
                325                 330                 335     


Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro 
            340                 345                 350         


Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln 
        355                 360                 365             


Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg 
    370                 375                 380                 


Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu 
385                 390                 395                 400 


Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His 
                405                 410                 415     


Ser Ser His Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys 
            420                 425                 430         


Lys Leu Met Phe Lys Thr Glu Gly Pro Asp Ser Asp 
        435                 440                 


<210>  40
<211>  371
<212>  PRT
<213>  Squence artificielle

<400>  40

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
                325                 330                 335     


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            340                 345                 350         


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        355                 360                 365             


Leu Lys Gln 
    370     


<210>  41
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  41

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met His His His His His His His His Lys Arg Tyr Lys 
    50                  55                  60                  


Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu 
65                  70                  75                  80  


Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg 
                85                  90                  95      


Leu Arg Leu Leu Leu Lys Gln Met Cys Lys Leu Ala Lys Phe Val Ala 
            100                 105                 110         


Ala Trp Thr Leu Lys Ala Ala Ala Gly Ser Asp Glu Val Ser Gly Leu 
        115                 120                 125             


Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr 
    130                 135                 140                 


Ser Ser Asn Val Met Glu Glu Arg Lys Ile Lys Val Tyr Leu Pro Arg 
145                 150                 155                 160 


Met Lys Met Glu Glu Lys Tyr Asn Leu Thr Ser Val Leu Met Ala Met 
                165                 170                 175     


Gly Ile Thr Asp Val Phe Ser Ser Ser Ala Asn Leu Ser Gly Ile Ser 
            180                 185                 190         


Ser Ala Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala 
        195                 200                 205             


Glu Ile Asn Glu Ala Gly Arg Glu Val Val Gly Ser Ala Glu Ala Gly 
    210                 215                 220                 


Val Asp Ala Ala Ser Val Ser Glu Glu Phe Arg Ala Asp His Pro Phe 
225                 230                 235                 240 


Leu Phe Cys Ile Lys His Ile Ala Thr Asn Ala 
                245                 250     


<210>  42
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  42

Met Arg His Met Gln Ser Ala Thr Arg Ala Thr Leu Val Cys Gly Ser 
1               5                   10                  15      


Gly Val Lys Gln Ile Ile Ala Lys Gly His Pro Asn Thr Arg Val Phe 
            20                  25                  30          


Gly Ala Arg Lys Ala Arg Ile Pro Glu Arg Glu Val Leu Ala Ala Lys 
        35                  40                  45              


Pro Lys Ile Thr Arg Ile Thr His Leu Asn Leu Gln Pro Gln Glu Arg 
    50                  55                  60                  


Gln Ala Phe Tyr Arg Leu Leu Glu Asn Glu Leu Ile Gln Glu Phe Leu 
65                  70                  75                  80  


Ser Met Asp Ser Cys Leu Lys Ile Ser Asp Lys Tyr Leu Ile Ala Met 
                85                  90                  95      


Val Leu Ala Tyr Phe Lys Arg Ala Gly Leu Tyr Thr Gly Glu Tyr Thr 
            100                 105                 110         


Thr Met Asn Phe Phe Val Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu 
        115                 120                 125             


Asp Glu Glu Asp Tyr Lys Tyr Glu Ile Phe Pro Trp Ala Leu Gly Asp 
    130                 135                 140                 


Ser Trp Arg Glu Phe Phe Pro Gln Phe Leu Arg Leu Arg Asp Asn Phe 
145                 150                 155                 160 


Trp Ala Lys Met Asn Tyr Arg Ala Val Val Ser Arg Arg Cys Cys Asp 
                165                 170                 175     


Glu Val Met Ala Lys Asp Pro Thr His Trp Ala Trp Leu Arg Asp Arg 
            180                 185                 190         


Pro Ile His His Ser Gly Ala Leu Arg Gly Tyr Leu Arg Asn Glu Asp 
        195                 200                 205             


Asp Phe Phe Pro Arg Gly Pro Gly Leu Thr Pro Ala Ser Cys Ala Leu 
    210                 215                 220                 


Cys His Lys Ala Ser Val Cys Asp Ser Gly Gly Val Ala His Asp Asn 
225                 230                 235                 240 


Ser Ser Pro Glu Gln Glu Ile Phe His Tyr Thr Asn Arg Glu Trp Ser 
                245                 250                 255     


Gln Glu Leu Leu Ile Leu Pro Pro Glu Leu Leu Leu Asp Pro Glu Ser 
            260                 265                 270         


Thr Tyr Asp Ile His Ile Phe Gln Glu Pro Leu Val Gly Leu Glu Pro 
        275                 280                 285             


Asp Gly Ala Ala Leu Glu Trp His His Leu Glu Cys Asp Ser Glu Leu 
    290                 295                 300                 


Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala 
305                 310                 315                 320 


Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 
                325                 330                 335     


Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
            340                 345                 


<210>  43
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  43

Gln Glu Val Gln Ala Phe Leu Ser Leu Leu Glu Asp Ser Phe Val Gln 
1               5                   10                  15      


Glu Phe Leu Ser Lys Asp Pro Cys Phe Gln Ile Ser Asp Lys Tyr Leu 
            20                  25                  30          


Leu Ala Met Val Leu Val Tyr Phe Gln Arg Ala His Leu Lys Leu Ser 
        35                  40                  45              


Glu Tyr Thr His Ser Ser Leu Phe Leu Ala Leu Tyr Leu Ala Asn Asp 
    50                  55                  60                  


Met Glu Glu Asp Leu Glu Gly Pro Lys Cys Glu Ile Phe Pro Trp Ala 
65                  70                  75                  80  


Leu Gly Lys Asp Trp Cys Leu Arg Val Gly Lys Phe Leu His Gln Arg 
                85                  90                  95      


Asp Lys Leu Trp Ala Arg Met Gly Phe Arg Ala Val Val Ser Arg Gln 
            100                 105                 110         


Cys Cys Glu Glu Val Met Ala Lys Glu Pro Phe His Trp Ala Trp Thr 
        115                 120                 125             


Arg Asp Arg Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn 
    130                 135                 140                 


Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln 
145                 150                 155                 160 


His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu 
                165                 170                 175     


Arg Leu Leu Leu Lys Gln 
            180         


<210>  44
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  44

Met Pro Arg Glu Arg Lys Glu Arg Asp Ser Lys Asp His Ser Asn Met 
1               5                   10                  15      


Lys Glu Glu Gly Gly Ser Asp Leu Ser Val Arg Ser Arg Lys Arg Lys 
            20                  25                  30          


Ala Asn Val Ala Val Phe Leu Gln Asp Pro Asp Glu Glu Ile Ala Lys 
        35                  40                  45              


Ile Asp Lys Thr Val Lys Ser Gln Asp Ser Ser Gln Pro Trp Asp Asp 
    50                  55                  60                  


Asp Ser Ala Cys Val Asp Pro Cys Ser Phe Ile Pro Thr Pro Asn Lys 
65                  70                  75                  80  


Glu Glu Asp Asn Glu Leu Glu Tyr Pro Lys Thr Ala Phe Gln Pro Arg 
                85                  90                  95      


Lys Ile Arg Pro Pro Arg Ala Ser Pro Leu Pro Val Leu Asn Trp Gly 
            100                 105                 110         


Asn Arg Glu Glu Val Trp Arg Ile Met Leu Asn Lys Glu Lys Thr Tyr 
        115                 120                 125             


Leu Arg Asp Glu His Phe Leu Gln Arg His Pro Leu Leu Gln Ala Arg 
    130                 135                 140                 


Met Arg Ala Val Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr 
145                 150                 155                 160 


Lys Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg 
                165                 170                 175     


Tyr Met Ala Ser Gln Gln Asn Ile Ile Lys Thr Leu Leu Gln Leu Ile 
            180                 185                 190         


Gly Ile Ser Ala Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Pro 
        195                 200                 205             


Pro Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Gly 
    210                 215                 220                 


Asp Glu Ile Leu Thr Met Glu Leu Met Met Met Lys Ala Leu Lys Trp 
225                 230                 235                 240 


Arg Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Val Gln 
                245                 250                 255     


Val Ala Tyr Val Asn Asp Thr Gly Glu Val Leu Met Pro Gln Tyr Pro 
            260                 265                 270         


Gln Gln Val Phe Val Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu 
        275                 280                 285             


Asp Val Gly Cys Leu Glu Phe Pro Tyr Gly Val Leu Ala Ala Ser Ala 
    290                 295                 300                 


Leu Tyr His Phe Ser Ser Leu Glu Leu Met Gln Lys Val Ser Gly Tyr 
305                 310                 315                 320 


Gln Trp Cys Asp Ile Glu Lys Cys Val Lys Trp Met Val Pro Phe Ala 
                325                 330                 335     


Met Val Ile Arg Glu Met Gly Ser Ser Lys Leu Lys His Phe Arg Gly 
            340                 345                 350         


Val Pro Met Glu Asp Ser His Asn Ile Gln Thr His Thr Asn Ser Leu 
        355                 360                 365             


Asp Leu Leu Asp Lys Ala Gln Ala Lys Lys Ala Ile Leu Ser Glu Gln 
    370                 375                 380                 


Asn Arg Ile Ser Pro Pro Pro Ser Gly Val Leu Thr Pro Pro His Ser 
385                 390                 395                 400 


Ser Lys Lys Gln Ser Ser Glu Gln Glu Thr Glu Glu Cys Asp Ser Glu 
                405                 410                 415     


Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg 
            420                 425                 430         


Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala 
        435                 440                 445             


Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
    450                 455                 460         


<210>  45
<211>  71
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  45

Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg Leu Ser Pro Leu Thr 
1               5                   10                  15      


Ile Val Ser Trp Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys 
            20                  25                  30          


Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu 
        35                  40                  45              


Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg 
    50                  55                  60                  


Leu Arg Leu Leu Leu Lys Gln 
65                  70      


<210>  46
<211>  377
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  46

Met Asp Leu Thr Ala Ile Tyr Glu Ser Leu Leu Ser Leu Ser Pro Asp 
1               5                   10                  15      


Val Pro Val Pro Ser Asp His Gly Gly Thr Glu Ser Ser Pro Gly Trp 
            20                  25                  30          


Gly Ser Ser Gly Pro Trp Ser Leu Ser Pro Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Gly Val Thr Ser Arg Leu Pro Gly Arg Ser Thr Ser Leu Val Glu Gly 
    50                  55                  60                  


Arg Ser Cys Gly Trp Val Pro Pro Pro Pro Gly Phe Ala Pro Leu Ala 
65                  70                  75                  80  


Pro Arg Leu Gly Pro Glu Leu Ser Pro Ser Pro Thr Ser Pro Thr Ala 
                85                  90                  95      


Thr Ser Thr Thr Pro Ser Arg Tyr Lys Thr Glu Leu Cys Arg Thr Phe 
            100                 105                 110         


Ser Glu Ser Gly Arg Cys Arg Tyr Gly Ala Lys Cys Gln Phe Ala His 
        115                 120                 125             


Gly Leu Gly Glu Leu Arg Gln Ala Asn Arg His Pro Lys Tyr Lys Thr 
    130                 135                 140                 


Glu Leu Cys His Lys Phe Tyr Leu Gln Gly Arg Cys Pro Tyr Gly Ser 
145                 150                 155                 160 


Arg Cys His Phe Ile His Asn Pro Ser Glu Asp Leu Ala Ala Pro Gly 
                165                 170                 175     


His Pro Pro Val Leu Arg Gln Ser Ile Ser Phe Ser Gly Leu Pro Ser 
            180                 185                 190         


Gly Arg Arg Thr Ser Pro Pro Pro Pro Gly Leu Ala Gly Pro Ser Leu 
        195                 200                 205             


Ser Ser Ser Ser Phe Ser Pro Ser Ser Ser Pro Pro Pro Pro Gly Asp 
    210                 215                 220                 


Leu Pro Leu Ser Pro Ser Ala Phe Ser Ala Ala Pro Gly Thr Pro Leu 
225                 230                 235                 240 


Ala Arg Arg Asp Pro Thr Pro Val Cys Cys Pro Ser Cys Arg Arg Ala 
                245                 250                 255     


Thr Pro Ile Ser Val Trp Gly Pro Leu Gly Gly Leu Val Arg Thr Pro 
            260                 265                 270         


Ser Val Gln Ser Leu Gly Ser Asp Pro Asp Glu Tyr Ala Ser Ser Gly 
        275                 280                 285             


Ser Ser Leu Gly Gly Ser Asp Ser Pro Val Phe Glu Ala Gly Val Phe 
    290                 295                 300                 


Ala Pro Pro Gln Pro Val Ala Ala Pro Arg Arg Leu Pro Ile Phe Asn 
305                 310                 315                 320 


Arg Ile Ser Val Ser Glu Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg 
                325                 330                 335     


Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln 
            340                 345                 350         


Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn 
        355                 360                 365             


Asp Arg Leu Arg Leu Leu Leu Lys Gln 
    370                 375         


<210>  47
<211>  406
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  47

Met Pro Phe Leu Gly Gln Asp Trp Arg Ser Pro Gly Gln Asn Trp Val 
1               5                   10                  15      


Lys Thr Ala Asp Gly Trp Lys Arg Phe Leu Asp Glu Lys Ser Gly Ser 
            20                  25                  30          


Phe Val Ser Asp Leu Ser Ser Tyr Cys Asn Lys Glu Val Tyr Asn Lys 
        35                  40                  45              


Glu Asn Leu Phe Asn Ser Leu Asn Tyr Asp Val Ala Ala Lys Lys Arg 
    50                  55                  60                  


Lys Lys Asp Met Leu Asn Ser Lys Thr Lys Thr Gln Tyr Phe His Gln 
65                  70                  75                  80  


Glu Lys Trp Ile Tyr Val His Lys Gly Ser Thr Lys Glu Arg His Gly 
                85                  90                  95      


Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu Asp Phe Ser Thr Ala 
            100                 105                 110         


Ile Leu Asp Ser Arg Arg Phe Asn Tyr Val Val Arg Leu Leu Glu Leu 
        115                 120                 125             


Ile Ala Lys Ser Gln Leu Thr Ser Leu Ser Gly Ile Ala Gln Lys Asn 
    130                 135                 140                 


Phe Met Asn Ile Leu Glu Lys Val Val Leu Lys Val Leu Glu Asp Gln 
145                 150                 155                 160 


Gln Asn Ile Arg Leu Ile Arg Glu Leu Leu Gln Thr Leu Tyr Thr Ser 
                165                 170                 175     


Leu Cys Thr Leu Val Gln Arg Val Gly Lys Ser Val Leu Val Gly Asn 
            180                 185                 190         


Ile Asn Met Trp Val Tyr Arg Met Glu Thr Ile Leu His Trp Gln Gln 
        195                 200                 205             


Gln Leu Asn Asn Ile Gln Ile Thr Arg Pro Ala Phe Lys Gly Leu Thr 
    210                 215                 220                 


Phe Thr Asp Leu Pro Leu Cys Leu Gln Leu Asn Ile Met Gln Arg Leu 
225                 230                 235                 240 


Ser Asp Gly Arg Asp Leu Val Ser Leu Gly Gln Ala Ala Pro Asp Leu 
                245                 250                 255     


His Val Leu Ser Glu Asp Arg Leu Leu Trp Lys Lys Leu Cys Gln Tyr 
            260                 265                 270         


His Phe Ser Glu Arg Gln Ile Arg Lys Arg Leu Ile Leu Ser Asp Lys 
        275                 280                 285             


Gly Gln Leu Asp Trp Lys Lys Met Tyr Phe Lys Leu Val Arg Cys Tyr 
    290                 295                 300                 


Pro Arg Lys Glu Gln Tyr Gly Asp Thr Leu Gln Leu Cys Lys His Cys 
305                 310                 315                 320 


His Ile Leu Ser Trp Lys Gly Thr Asp His Pro Cys Thr Ala Asn Asn 
                325                 330                 335     


Pro Glu Ser Cys Ser Val Ser Leu Ser Pro Gln Asp Phe Ile Asn Leu 
            340                 345                 350         


Phe Lys Phe Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn 
        355                 360                 365             


Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln 
    370                 375                 380                 


His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu 
385                 390                 395                 400 


Arg Leu Leu Leu Lys Gln 
                405     


<210>  48
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  48

Gly Gln Thr Pro Ala Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro 
1               5                   10                  15      


Ala Leu Pro Gly Pro Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val 
            20                  25                  30          


Val Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu 
        35                  40                  45              


Arg Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr 
    50                  55                  60                  


Val Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Pro His 
65                  70                  75                  80  


Asn Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn 
                85                  90                  95      


Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly 
            100                 105                 110         


Trp Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val Leu Ile His 
        115                 120                 125             


Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp 
    130                 135                 140                 


Thr Ser Leu Gln Asn Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr 
145                 150                 155                 160 


Leu Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu 
                165                 170                 175     


Thr Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu 
            180                 185                 190         


Ile Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser 
        195                 200                 205             


Asp Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu 
    210                 215                 220                 


Ser Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser 
225                 230                 235                 240 


Ala Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val 
                245                 250                 255     


Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile 
            260                 265                 270         


Asn Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln 
        275                 280                 285             


Ile Ala Leu Asn Glu Lys Leu Val Asn Leu Glu Cys Asp Ser Glu Leu 
    290                 295                 300                 


Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala 
305                 310                 315                 320 


Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 
                325                 330                 335     


Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
            340                 345                 


<210>  49
<211>  257
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  49

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Arg Pro 
1               5                   10                  15      


Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val Val 
            20                  25                  30          


Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser Gly 
        35                  40                  45              


Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val 
    50                  55                  60                  


Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met 
65                  70                  75                  80  


Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val 
                85                  90                  95      


Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu 
            100                 105                 110         


Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr 
        115                 120                 125             


Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe 
    130                 135                 140                 


Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe 
145                 150                 155                 160 


Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala 
                165                 170                 175     


Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu 
            180                 185                 190         


Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu Glu Cys 
        195                 200                 205             


Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg 
    210                 215                 220                 


Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val 
225                 230                 235                 240 


Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 
                245                 250                 255     


Gln 
    


<210>  50
<211>  835
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  50

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
785                 790                 795                 800 


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
                805                 810                 815     


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
            820                 825                 830         


Leu Lys Gln 
        835 


<210>  51
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine


<220>
<221>  SITE
<222>  (5)..(5)
<223>  la tyrosine Y5 est phosphoryle par la src kinase

<400>  51

Arg Pro Ser Leu Tyr Ala Gln Val Gln Glu Cys Asp Ser Glu Leu Glu 
1               5                   10                  15      


Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys 
            20                  25                  30          


Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 
        35                  40                  45              


Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
    50                  55                  60  


<210>  52
<211>  444
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  52

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp Glu Cys Asp Ser Glu Leu Glu 
385                 390                 395                 400 


Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys 
                405                 410                 415     


Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 
            420                 425                 430         


Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
        435                 440                 


<210>  53
<211>  371
<212>  PRT
<213>  squence artificielle

<400>  53

Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 
1               5                   10                  15      


Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 
            20                  25                  30          


Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 
        35                  40                  45              


Leu Lys Gln Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp 
    50                  55                  60                  


Ala Glu Leu Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu 
65                  70                  75                  80  


Phe Asp Gln Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe 
                85                  90                  95      


Gly Leu His Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu 
            100                 105                 110         


Asp Lys Lys Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln 
        115                 120                 125             


Phe Lys Phe Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu 
    130                 135                 140                 


Ile Gln Asp Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly 
145                 150                 155                 160 


Ile Leu Ser Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu 
                165                 170                 175     


Gly Ser Tyr Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val 
            180                 185                 190         


His Lys Ser Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val 
        195                 200                 205             


Met Asp Gln His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln 
    210                 215                 220                 


Val Trp His Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu 
225                 230                 235                 240 


Glu Tyr Leu Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr 
                245                 250                 255     


Phe Glu Ile Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp 
            260                 265                 270         


Ala Leu Gly Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys 
        275                 280                 285             


Ile Gly Phe Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys 
    290                 295                 300                 


Lys Phe Val Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe 
305                 310                 315                 320 


Tyr Ala Pro Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met 
                325                 330                 335     


Gly Asn His Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu 
            340                 345                 350         


Val Gln Gln Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln 
        355                 360                 365             


Leu Glu Arg 
    370     


<210>  54
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  driv de protine humaine

<400>  54

Met His His His His His His His His Lys Arg Tyr Lys Asn Arg Val 
1               5                   10                  15      


Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr 
            20                  25                  30          


Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 
        35                  40                  45              


Leu Leu Lys Gln Met Cys Lys Leu Ala Lys Phe Val Ala Ala Trp Thr 
    50                  55                  60                  


Leu Lys Ala Ala Ala Gly Ser Asp Glu Val Ser Gly Leu Glu Gln Leu 
65                  70                  75                  80  


Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr Ser Ser Asn 
                85                  90                  95      


Val Met Glu Glu Arg Lys Ile Lys Val Tyr Leu Pro Arg Met Lys Met 
            100                 105                 110         


Glu Glu Lys Tyr Asn Leu Thr Ser Val Leu Met Ala Met Gly Ile Thr 
        115                 120                 125             


Asp Val Phe Ser Ser Ser Ala Asn Leu Ser Gly Ile Ser Ser Ala Glu 
    130                 135                 140                 


Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn 
145                 150                 155                 160 


Glu Ala Gly Arg Glu Val Val Gly Ser Ala Glu Ala Gly Val Asp Ala 
                165                 170                 175     


Ala Ser Val Ser Glu Glu Phe Arg Ala Asp His Pro Phe Leu Phe Cys 
            180                 185                 190         


Ile Lys His Ile Ala Thr Asn Ala Glu Cys Asp Ser Glu Leu Glu Ile 
        195                 200                 205             


Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe 
    210                 215                 220                 


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
225                 230                 235                 240 


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
                245                 250     


<210>  55
<211>  105
<212>  PRT
<213>  Squence artificielle

<400>  55

Leu Ala Asp Ile Gly Val Pro Gln Pro Ala Pro Val Ala Ala Pro Ala 
1               5                   10                  15      


Arg Arg Thr Arg Lys Pro Gln Gln Pro Glu Ser Leu Glu Glu Cys Asp 
            20                  25                  30          


Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys 
        35                  40                  45              


Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala 
    50                  55                  60                  


Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 
65                  70                  75                  80  


Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp 
                85                  90                  95      


Val Leu His Glu Asp Leu Leu Asn Phe 
            100                 105 


<210>  56
<211>  75
<212>  PRT
<213>  Squence artificelle

<400>  56

Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser 
1               5                   10                  15      


Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu 
            20                  25                  30          


Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu 
        35                  40                  45              


Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr 
    50                  55                  60                  


Pro Asp Val Leu His Glu Asp Leu Leu Asn Phe 
65                  70                  75  


