                         SEQUENCE LISTING

<110>  Crine, Philippe
       Leonard, Pierre
 
<120>  METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MATRIX 
       MINERALIZATION DISORDERS

<130>  765/12944.9

<150>  61/329,877
<151>  2010-04-30

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hsTNALP-Fc with N-terminal signal sequence

<400>  1

Met Val Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                565                 570                 575     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            580                 585                 590         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730     


<210>  2
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hsTNALP 1-502

<400>  2

Met Val Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser 
            500         


<210>  3
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-1 Fc fragment

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hsTNALP-Fc without N-terminal signal sequence

<400>  4

Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 
1               5                   10                  15      


Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 
            20                  25                  30          


Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 
        35                  40                  45              


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 
    50                  55                  60                  


Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 
65                  70                  75                  80  


Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 
                85                  90                  95      


Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 
            100                 105                 110         


Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 
        115                 120                 125             


Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 
    130                 135                 140                 


Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 
145                 150                 155                 160 


Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 
                165                 170                 175     


Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 
            180                 185                 190         


His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 
        195                 200                 205             


Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 
    210                 215                 220                 


Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 
225                 230                 235                 240 


Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 
                245                 250                 255     


Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 
            260                 265                 270         


Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 
        275                 280                 285             


Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 
    290                 295                 300                 


Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 
305                 310                 315                 320 


His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 
                325                 330                 335     


Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 
            340                 345                 350         


Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 
        355                 360                 365             


Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 
    370                 375                 380                 


Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 
385                 390                 395                 400 


Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 
                405                 410                 415     


Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 
            420                 425                 430         


Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 
        435                 440                 445             


Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 
    450                 455                 460                 


His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 
465                 470                 475                 480 


Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
                485                 490                 495     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            500                 505                 510         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        515                 520                 525             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    530                 535                 540                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
545                 550                 555                 560 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                565                 570                 575     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            580                 585                 590         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        595                 600                 605             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    610                 615                 620                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
625                 630                 635                 640 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                645                 650                 655     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            660                 665                 670         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        675                 680                 685             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    690                 695                 700                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 


<210>  5
<211>  485
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hsTNALP without N-terminal signal sequence

<400>  5

Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 
1               5                   10                  15      


Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 
            20                  25                  30          


Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 
        35                  40                  45              


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 
    50                  55                  60                  


Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 
65                  70                  75                  80  


Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 
                85                  90                  95      


Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 
            100                 105                 110         


Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 
        115                 120                 125             


Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 
    130                 135                 140                 


Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 
145                 150                 155                 160 


Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 
                165                 170                 175     


Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 
            180                 185                 190         


His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 
        195                 200                 205             


Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 
    210                 215                 220                 


Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 
225                 230                 235                 240 


Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 
                245                 250                 255     


Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 
            260                 265                 270         


Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 
        275                 280                 285             


Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 
    290                 295                 300                 


Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 
305                 310                 315                 320 


His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 
                325                 330                 335     


Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 
            340                 345                 350         


Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 
        355                 360                 365             


Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 
    370                 375                 380                 


Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 
385                 390                 395                 400 


Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 
                405                 410                 415     


Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 
            420                 425                 430         


Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 
        435                 440                 445             


Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 
    450                 455                 460                 


His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 
465                 470                 475                 480 


Ala Pro Ala Ser Ser 
                485 


<210>  6
<211>  524
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TNALP

<400>  6

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
            500                 505                 510         


Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        515                 520                 


<210>  7
<211>  524
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<223>  TNALP

<400>  7

Met Ile Ser Pro Phe Leu Leu Leu Ala Ile Gly Thr Cys Phe Ala Ser 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Gln Thr Leu Lys Asn Ala Leu Arg Leu Gln Thr Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Ser 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Lys Leu Glu Met Asp Lys Phe Pro Tyr Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Gln Arg Ser Gln Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ser Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Lys Asp Ile Glu Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asn Leu Ile Asp Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Lys His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Asp Leu Leu Ala Leu Asp Pro His Ser Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Ala 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Met Ala Ile Arg Ile Leu 
305                 310                 315                 320 


Asn Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Gln Ala Ile Gly Gln Ala Gly Ala Met Thr Ser Val 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Arg Asp His 
                485                 490                 495     


Cys Ala Ser Ala Ser Ser Ser Gly Ser Pro Ser Pro Gly Pro Leu Leu 
            500                 505                 510         


Leu Leu Leu Ala Leu Leu Pro Leu Gly Ser Leu Phe 
        515                 520                 


<210>  8
<211>  524
<212>  PRT
<213>  Felis catus


<220>
<221>  MISC_FEATURE
<223>  TNALP

<400>  8

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Gln Thr Leu Lys Asn Ala Leu Arg Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Val Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Tyr Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Gln Arg Thr Gln Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ser Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Val Arg Asp Ile Glu Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Met Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asn Leu Val Asp Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro Tyr Gly Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Ser Thr 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Ile Ala Ile Lys Ile Leu 
305                 310                 315                 320 


Ser Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Gln Ala Ile Gly Arg Ala Gly Ala Met Thr Ser Val 
        355                 360                 365             


Glu Asp Thr Leu Thr Ile Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ser Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Asp His 
                485                 490                 495     


Cys Ala Ser Ala Ser Ser Ala Gly Gly Pro Ser Pro Gly Pro Leu Phe 
            500                 505                 510         


Leu Leu Leu Ala Leu Pro Ser Leu Gly Ile Leu Phe 
        515                 520                 


<210>  9
<211>  524
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  TNALP

<400>  9

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Phe Val Pro Glu Lys Glu Arg Asp Pro Ser Tyr Trp Arg Gln Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Asn Ala Leu Lys Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Thr Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Thr Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Lys Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Ile Ser Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Ala Leu Asp Pro Ser Arg Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Leu 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Val Ala Leu Arg Ile Leu 
305                 310                 315                 320 


Thr Lys Asn Leu Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Gln Ala Ile Gly Lys Ala Gly Ala Met Thr Ser Gln 
        355                 360                 365             


Lys Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Asp Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ser Cys Ile Gly Ala Asn Leu Asp His 
                485                 490                 495     


Cys Ala Trp Ala Gly Ser Gly Ser Ala Pro Ser Pro Gly Ala Leu Leu 
            500                 505                 510         


Leu Pro Leu Ala Val Leu Ser Leu Pro Thr Leu Phe 
        515                 520                 


<210>  10
<211>  524
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<223>  TNALP

<400>  10

Met Ile Leu Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Phe Val Pro Glu Lys Glu Lys Asp Pro Ser Tyr Trp Arg Gln Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Asn Ala Leu Lys Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Ile Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Thr Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Thr Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Lys Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Ile Ser Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Ala Leu Asp Pro Ser Arg Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Leu 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Val Ala Leu Arg Ile Leu 
305                 310                 315                 320 


Thr Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Glu Ala Ile Gly Lys Ala Gly Thr Met Thr Ser Gln 
        355                 360                 365             


Lys Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Asp Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ser Cys Ile Gly Ala Asn Leu Asp His 
                485                 490                 495     


Cys Ala Trp Ala Ser Ser Ala Ser Ser Pro Ser Pro Gly Ala Leu Leu 
            500                 505                 510         


Leu Pro Leu Ala Leu Phe Pro Leu Arg Thr Leu Phe 
        515                 520                 


<210>  11
<211>  502
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<223>  TNALP

<400>  11

Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala Gln Gln Thr Leu Lys 
1               5                   10                  15      


Tyr Ala Leu Arg Leu Gln Asn Leu Asn Thr Asn Val Ala Lys Asn Val 
            20                  25                  30          


Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser Thr Val Thr Ala Thr 
        35                  40                  45              


Arg Ile Leu Lys Gly Gln Leu His His Asn Pro Gly Glu Glu Thr Arg 
    50                  55                  60                  


Leu Glu Met Asp Lys Phe Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn 
65                  70                  75                  80  


Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr Ala Thr Ala Tyr Leu 
                85                  90                  95      


Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly Val Ser Ala Ala Thr 
            100                 105                 110         


Gln Arg Thr His Cys Asn Thr Thr Gln Gly Asn Glu Val Thr Ser Ile 
        115                 120                 125             


Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val Gly Ile Val Thr Thr 
    130                 135                 140                 


Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala Tyr Ala His Ser Ala 
145                 150                 155                 160 


Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro Pro Glu Ala Leu Ser 
                165                 170                 175     


Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met His Asn Val Lys Asp 
            180                 185                 190         


Ile Glu Val Ile Met Gly Gly Gly Arg Lys Tyr Met Phe Pro Lys Asn 
        195                 200                 205             


Arg Thr Asp Val Glu Tyr Glu Met Asp Glu Lys Ser Thr Gly Ala Arg 
    210                 215                 220                 


Leu Asp Gly Leu Asn Leu Ile Asp Ile Trp Lys Asn Phe Lys Pro Arg 
225                 230                 235                 240 


His Lys His Ser His Tyr Val Trp Asn Arg Thr Glu Leu Leu Ala Leu 
                245                 250                 255     


Asp Pro Tyr Thr Val Asp Tyr Leu Leu Gly Leu Phe Asp Pro Gly Asp 
            260                 265                 270         


Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr Asp Pro Ser Leu Ser 
        275                 280                 285             


Glu Met Val Glu Ile Ala Ile Lys Ile Leu Ser Lys Lys Pro Arg Gly 
    290                 295                 300                 


Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp His Gly His His Glu 
305                 310                 315                 320 


Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val Glu Met Asp Arg Ala 
                325                 330                 335     


Ile Gly Lys Ala Gly Val Met Thr Ser Leu Glu Asp Thr Leu Thr Val 
            340                 345                 350         


Val Thr Ala Asp His Ser His Val Phe Thr Phe Gly Gly Tyr Thr Pro 
        355                 360                 365             


Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met Val Ser Asp Thr Asp 
    370                 375                 380                 


Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn Gly Pro Gly Tyr Lys 
385                 390                 395                 400 


Val Val Gly Gly Glu Arg Glu Asn Val Ser Met Val Asp Tyr Ala His 
                405                 410                 415     


Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu Arg His Glu Thr His 
            420                 425                 430         


Gly Gly Glu Asp Val Ala Val Phe Ala Lys Gly Pro Met Ala His Leu 
        435                 440                 445             


Leu His Gly Val His Glu Gln Asn Tyr Ile Pro His Val Met Ala Tyr 
    450                 455                 460                 


Ala Ala Cys Ile Gly Ala Asn Gln Asp His Cys Ala Ser Ala Ser Ser 
465                 470                 475                 480 


Ala Gly Gly Pro Ser Pro Gly Pro Leu Leu Leu Leu Leu Ala Leu Leu 
                485                 490                 495     


Pro Val Gly Ile Leu Phe 
            500         


<210>  12
<211>  528
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IALP

<400>  12

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


<210>  13
<211>  532
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GCALP

<400>  13

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Phe Leu Ala Met Asp Arg Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Ser Val Asp Lys His Val Pro Asp Ser Gly 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr 
225                 230                 235                 240 


Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Leu Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Gly 
        435                 440                 445             


Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Arg Ala Gly Thr Thr Asp Ala Ala His Pro Gly Pro Ser Val Val 
            500                 505                 510         


Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Thr 
        515                 520                 525             


Ala Thr Ala Pro 
    530         


<210>  14
<211>  535
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PLALP

<400>  14

Met Leu Gly Pro Cys Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg 
1               5                   10                  15      


Leu Gln Leu Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp 
            20                  25                  30          


Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu 
        35                  40                  45              


Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp 
    50                  55                  60                  


Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln 
65                  70                  75                  80  


Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe 
                85                  90                  95      


Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro 
            100                 105                 110         


Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn 
        115                 120                 125             


Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn 
    130                 135                 140                 


Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys 
145                 150                 155                 160 


Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala 
                165                 170                 175     


Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser 
            180                 185                 190         


Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile 
        195                 200                 205             


Ala Thr Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly 
    210                 215                 220                 


Gly Arg Lys Tyr Met Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro 
225                 230                 235                 240 


Asp Asp Tyr Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val 
                245                 250                 255     


Gln Glu Trp Leu Ala Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Met Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met 
        275                 280                 285             


Gly Leu Phe Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser 
    290                 295                 300                 


Thr Leu Asp Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu 
305                 310                 315                 320 


Leu Ser Arg Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg 
                325                 330                 335     


Ile Asp His Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu 
            340                 345                 350         


Thr Ile Met Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser 
        355                 360                 365             


Glu Glu Asp Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe 
    370                 375                 380                 


Ser Phe Gly Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala 
385                 390                 395                 400 


Pro Gly Lys Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr 
            420                 425                 430         


Glu Ser Glu Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Asp Glu Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg 
    450                 455                 460                 


Gly Pro Gln Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile 
465                 470                 475                 480 


Ala His Val Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys 
                485                 490                 495     


Asp Leu Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Gly Arg 
            500                 505                 510         


Ser Val Val Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu 
        515                 520                 525             


Leu Glu Thr Ala Thr Ala Pro 
    530                 535 


<210>  15
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus ALP


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (5)..(9)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid except 
       phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid except cysteine

<220>
<221>  MISC_FEATURE
<222>  (35)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (46)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (50)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid except serine or 
       valine

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid except leucine, 
       isoleucine or valine

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (82)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (90)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (116)..(116)
<223>  Xaa can be any naturally occurring amino acid except threonine

<220>
<221>  VARIANT
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid except serine

<220>
<221>  VARIANT
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid except aspartate

<220>
<221>  MISC_FEATURE
<222>  (130)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (133)..(133)
<223>  Xaa can be any naturally occurring amino acid except methionine

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid except histidine or
       asparagine

<220>
<221>  MISC_FEATURE
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (141)..(141)
<223>  Xaa can be any naturally occurring amino acid except histidine

<220>
<221>  MISC_FEATURE
<222>  (142)..(143)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (153)..(153)
<223>  Xaa can be any naturally occurring amino acid except alanine or 
       isoleucine

<220>
<221>  MISC_FEATURE
<222>  (155)..(158)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (161)..(162)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid except aspartate

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (180)..(180)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (181)..(181)
<223>  Xaa can be any naturally occurring amino acid except threonine

<220>
<221>  VARIANT
<222>  (182)..(182)
<223>  Xaa can be any naturally occurring amino acid except threonine

<220>
<221>  VARIANT
<222>  (186)..(186)
<223>  Xaa can be any naturally occurring amino acid except leucine

<220>
<221>  MISC_FEATURE
<222>  (187)..(188)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (195)..(195)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (196)..(196)
<223>  Xaa can be any naturally occurring amino acid except lysine or 
       glycine

<220>
<221>  VARIANT
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid except threonine

<220>
<221>  MISC_FEATURE
<222>  (199)..(200)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (202)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (214)..(215)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (217)..(217)
<223>  Xaa can be any naturally occurring amino acid except 
       phenylalanine

<220>
<221>  VARIANT
<222>  (218)..(218)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (232)..(237)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (239)..(239)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (240)..(240)
<223>  Xaa can be any naturally occurring amino acid except glycine

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (245)..(248)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (255)..(256)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (258)..(260)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (263)..(265)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (266)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (269)..(269)
<223>  Xaa can be any naturally occurring amino acid except arginine

<220>
<221>  MISC_FEATURE
<222>  (270)..(274)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (279)..(279)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (281)..(286)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (287)..(287)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (290)..(291)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid except lysine

<220>
<221>  VARIANT
<222>  (301)..(301)
<223>  Xaa can be any naturally occurring amino acid except valine, 
       threonine or isoleucine

<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (305)..(305)
<223>  Xaa can be any naturally occurring amino acid except proline

<220>
<221>  MISC_FEATURE
<222>  (306)..(306)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (308)..(311)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (316)..(316)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (319)..(321)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (323)..(325)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (327)..(331)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (334)..(334)
<223>  Xaa can be any naturally occurring amino acid except leucine

<220>
<221>  MISC_FEATURE
<222>  (336)..(336)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (349)..(350)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (352)..(353)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (356)..(356)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (358)..(359)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (360)..(360)
<223>  Xaa can be any naturally occurring amino acid except aspartate

<220>
<221>  VARIANT
<222>  (361)..(361)
<223>  Xaa can be any naturally occurring amino acid except threonine or
       isoleucine

<220>
<221>  MISC_FEATURE
<222>  (363)..(363)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (366)..(367)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (370)..(371)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (374)..(375)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (379)..(379)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (380)..(380)
<223>  Xaa can be any naturally occurring amino acid except methionine

<220>
<221>  MISC_FEATURE
<222>  (390)..(390)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (395)..(395)
<223>  Xaa can be any naturally occurring amino acid except leucine

<220>
<221>  MISC_FEATURE
<222>  (396)..(396)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (399)..(399)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (407)..(410)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (411)..(411)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (413)..(413)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (415)..(415)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (416)..(416)
<223>  Xaa can be any naturally occurring amino acid except leucine

<220>
<221>  MISC_FEATURE
<222>  (418)..(419)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (428)..(428)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (429)..(429)
<223>  Xaa can be any naturally occurring amino acid except alanine

<220>
<221>  VARIANT
<222>  (430)..(430)
<223>  Xaa can be any naturally occurring amino acid except methionine

<220>
<221>  MISC_FEATURE
<222>  (431)..(431)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (433)..(433)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (435)..(435)
<223>  Xaa can be any naturally occurring amino acid except lysine

<220>
<221>  MISC_FEATURE
<222>  (436)..(436)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (438)..(441)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (442)..(442)
<223>  Xaa can be any naturally occurring amino acid except histidine

<220>
<221>  MISC_FEATURE
<222>  (443)..(446)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (448)..(449)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (451)..(451)
<223>  Xaa can be any naturally occurring amino acid except proline

<220>
<221>  VARIANT
<222>  (456)..(456)
<223>  Xaa can be any naturally occurring amino acid except histidine or
       cysteine

<220>
<221>  MISC_FEATURE
<222>  (457)..(457)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (461)..(461)
<223>  Xaa can be any naturally occurring amino acid except serine or 
       aspartate

<220>
<221>  MISC_FEATURE
<222>  (469)..(470)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (473)..(473)
<223>  Xaa can be any naturally occurring amino acid except threonine

<220>
<221>  MISC_FEATURE
<222>  (477)..(477)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (481)..(481)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (484)..(484)
<223>  Xaa can be any naturally occurring amino acid except leucine

<220>
<221>  MISC_FEATURE
<222>  (485)..(487)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (494)..(494)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (496)..(496)
<223>  Xaa can be any naturally occurring amino acid except 
       phenylalanine

<220>
<221>  VARIANT
<222>  (497)..(497)
<223>  Xaa can be any naturally occurring amino acid except arginine

<220>
<221>  VARIANT
<222>  (498)..(501)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (502)..(507)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (509)..(516)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (517)..(520)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (521)..(524)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (526)..(532)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (534)..(534)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (535)..(541)
<223>  Xaa can be any naturally occurring amino acid or absent

<400>  15

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Pro Xaa 
            20                  25                  30          


Xaa Trp Xaa Xaa Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Ala Xaa Xaa Leu 
        35                  40                  45              


Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Asn Xaa Ile Xaa Phe Leu Gly 
    50                  55                  60                  


Asp Gly Xaa Gly Val Xaa Thr Val Thr Ala Xaa Arg Ile Leu Lys Gly 
65                  70                  75                  80  


Gln Xaa Xaa Xaa Xaa Xaa Gly Xaa Glu Xaa Xaa Leu Xaa Met Asp Xaa 
                85                  90                  95      


Phe Pro Xaa Xaa Ala Leu Ser Lys Thr Tyr Xaa Xaa Xaa Xaa Xaa Val 
            100                 105                 110         


Pro Asp Ser Xaa Xaa Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Xaa 
        115                 120                 125             


Asn Xaa Xaa Thr Xaa Gly Xaa Ser Ala Ala Xaa Xaa Xaa Xaa Xaa Cys 
    130                 135                 140                 


Asn Thr Thr Xaa Gly Asn Glu Val Xaa Ser Xaa Xaa Xaa Xaa Ala Lys 
145                 150                 155                 160 


Xaa Xaa Gly Lys Ser Val Gly Xaa Val Thr Thr Thr Arg Val Xaa His 
                165                 170                 175     


Ala Xaa Pro Xaa Xaa Xaa Tyr Ala His Xaa Xaa Xaa Arg Xaa Trp Tyr 
            180                 185                 190         


Ser Asp Xaa Xaa Xaa Pro Xaa Xaa Ala Xaa Xaa Xaa Gly Cys Xaa Asp 
        195                 200                 205             


Ile Ala Xaa Gln Leu Xaa Xaa Asn Xaa Xaa Asp Ile Xaa Val Ile Xaa 
    210                 215                 220                 


Gly Gly Gly Arg Lys Tyr Met Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Glu 
225                 230                 235                 240 


Tyr Xaa Xaa Asp Xaa Xaa Xaa Xaa Gly Xaa Arg Leu Asp Gly Xaa Xaa 
                245                 250                 255     


Leu Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Trp Asn Arg Thr Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Val Xaa Xaa Leu Xaa Gly Leu Phe Xaa Pro Gly Asp Xaa Xaa Tyr Glu 
    290                 295                 300                 


Xaa Xaa Arg Xaa Xaa Xaa Xaa Asp Pro Ser Leu Xaa Glu Met Xaa Xaa 
305                 310                 315                 320 


Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Gly Phe Xaa Leu Xaa 
                325                 330                 335     


Val Glu Gly Gly Arg Ile Asp His Gly His His Glu Xaa Xaa Ala Xaa 
            340                 345                 350         


Xaa Ala Leu Xaa Glu Xaa Xaa Xaa Xaa Asp Xaa Ala Ile Xaa Xaa Ala 
        355                 360                 365             


Gly Xaa Xaa Thr Ser Xaa Xaa Asp Thr Leu Xaa Xaa Val Thr Ala Asp 
    370                 375                 380                 


His Ser His Val Phe Xaa Phe Gly Gly Tyr Xaa Xaa Arg Gly Xaa Ser 
385                 390                 395                 400 


Ile Phe Gly Leu Ala Pro Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Xaa Xaa 
                405                 410                 415     


Thr Xaa Xaa Leu Tyr Gly Asn Gly Pro Gly Tyr Xaa Xaa Xaa Xaa Gly 
            420                 425                 430         


Xaa Arg Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa 
        435                 440                 445             


Xaa Gln Xaa Ala Val Pro Leu Xaa Xaa Glu Thr His Xaa Gly Glu Asp 
    450                 455                 460                 


Val Ala Val Phe Xaa Xaa Gly Pro Xaa Ala His Leu Xaa His Gly Val 
465                 470                 475                 480 


Xaa Glu Gln Xaa Xaa Xaa Xaa His Val Met Ala Xaa Ala Xaa Cys Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540     


<210>  16
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus ALP


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid except serine or 
       valine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (80)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (137)..(138)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  Xaa can be any naturally occurring amino acid except threonine

<220>
<221>  VARIANT
<222>  (212)..(212)
<223>  Xaa can be any naturally occurring amino acid except 
       phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (213)..(213)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (253)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (262)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (268)..(269)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (274)..(274)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (281)..(282)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (291)..(291)
<223>  Xaa can be any naturally occurring amino acid except lysine

<220>
<221>  MISC_FEATURE
<222>  (303)..(304)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (314)..(315)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (317)..(318)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (321)..(321)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (323)..(325)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (364)..(365)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (368)..(369)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (374)..(374)
<223>  Xaa can be any naturally occurring amino acid except methionine

<220>
<221>  MISC_FEATURE
<222>  (402)..(402)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (425)..(425)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (463)..(463)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (480)..(480)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (488)..(488)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (494)..(495)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (499)..(499)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (503)..(508)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (514)..(514)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (517)..(522)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Ile Xaa Pro Phe Leu Xaa Leu Ala Ile Gly Thr Cys Xaa Xaa Xaa 
1               5                   10                  15      


Ser Xaa Val Pro Glu Lys Glu Xaa Asp Pro Xaa Tyr Trp Arg Xaa Gln 
            20                  25                  30          


Ala Gln Xaa Thr Leu Lys Xaa Ala Leu Xaa Leu Gln Xaa Leu Asn Thr 
        35                  40                  45              


Asn Val Xaa Lys Asn Xaa Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Xaa Arg Ile Leu Lys Gly Gln Leu His His Xaa 
65                  70                  75                  80  


Xaa Gly Glu Glu Thr Xaa Leu Glu Met Asp Lys Phe Pro Xaa Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Xaa Arg Xaa Xaa Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Xaa Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Xaa Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Xaa Xaa Asp Ile Xaa Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Xaa Pro Lys Asn Xaa Thr Asp Val Glu Tyr Glu Xaa Asp Glu 
225                 230                 235                 240 


Lys Xaa Xaa Gly Xaa Arg Leu Asp Gly Leu Xaa Leu Xaa Xaa Xaa Trp 
                245                 250                 255     


Lys Xaa Phe Lys Pro Xaa Xaa Lys His Ser His Xaa Xaa Trp Asn Arg 
            260                 265                 270         


Thr Xaa Leu Leu Xaa Leu Asp Pro Xaa Xaa Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Xaa Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Xaa Xaa 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Xaa Xaa Ala Xaa Xaa Ile Leu 
305                 310                 315                 320 


Xaa Lys Xaa Xaa Xaa Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Xaa Ala Ile Gly Xaa Ala Gly Xaa Xaa Thr Ser Xaa 
        355                 360                 365             


Xaa Asp Thr Leu Thr Xaa Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Xaa Ser Asp Thr Asp Lys Lys Pro Phe Thr Xaa Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Xaa Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Xaa Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Xaa 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Xaa Cys Ile Gly Ala Asn Xaa Xaa His 
                485                 490                 495     


Cys Ala Xaa Ala Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Leu Xaa 
            500                 505                 510         


Leu Xaa Leu Ala Xaa Xaa Xaa Xaa Xaa Xaa Leu Phe 
        515                 520                 


<210>  17
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hsTNALP-Fc

<400>  17
atggtttcac cattcttagt actggccatt ggcacctgcc ttactaactc cttagtgcca       60

gagaaagaga aagaccccaa gtactggcga gaccaagcgc aagagacact gaaatatgcc      120

ctggagcttc agaagctcaa caccaacgtg gctaagaatg tcatcatgtt cctgggagat      180

gggatgggtg tctccacagt gacggctgcc cgcatcctca agggtcagct ccaccacaac      240

cctggggagg agaccaggct ggagatggac aagttcccct tcgtggccct ctccaagacg      300

tacaacacca atgcccaggt ccctgacagc gccggcaccg ccaccgccta cctgtgtggg      360

gtgaaggcca atgagggcac cgtgggggta agcgcagcca ctgagcgttc ccggtgcaac      420

accacccagg ggaacgaggt cacctccatc ctgcgctggg ccaaggacgc tgggaaatct      480

gtgggcattg tgaccaccac gagagtgaac catgccaccc ccagcgccgc ctacgcccac      540

tcggctgacc gggactggta ctcagacaac gagatgcccc ctgaggcctt gagccagggc      600

tgtaaggaca tcgcctacca gctcatgcat aacatcaggg acattgacgt gatcatgggg      660

ggtggccgga aatacatgta ccccaagaat aaaactgatg tggagtatga gagtgacgag      720

aaagccaggg gcacgaggct ggacggcctg gacctcgttg acacctggaa gagcttcaaa      780

ccgagataca agcactccca cttcatctgg aaccgcacgg aactcctgac ccttgacccc      840

cacaatgtgg actacctatt gggtctcttc gagccagggg acatgcagta cgagctgaac      900

aggaacaacg tgacggaccc gtcactctcc gagatggtgg tggtggccat ccagatcctg      960

cggaagaacc ccaaaggctt cttcttgctg gtggaaggag gcagaattga ccacgggcac     1020

catgaaggaa aagccaagca ggccctgcat gaggcggtgg agatggaccg ggccatcggg     1080

caggcaggca gcttgacctc ctcggaagac actctgaccg tggtcactgc ggaccattcc     1140

cacgtcttca catttggtgg atacaccccc cgtggcaact ctatctttgg tctggccccc     1200

atgctgagtg acacagacaa gaagcccttc actgccatcc tgtatggcaa tgggcctggc     1260

tacaaggtgg tgggcggtga acgagagaat gtctccatgg tggactatgc tcacaacaac     1320

taccaggcgc agtctgctgt gcccctgcgc cacgagaccc acggcgggga ggacgtggcc     1380

gtcttctcca agggccccat ggcgcacctg ctgcacggcg tccacgagca gaactacgtc     1440

ccccacgtga tggcgtatgc agcctgcatc ggggccaacc tcggccactg tgctcctgcc     1500

agctcgctta aggacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1560

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1620

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1680

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1740

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1800

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1860

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1920

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1980

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     2040

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     2100

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2160

acgcagaaga gcctctccct gtctccgggt aaa                                  2193


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
gtccgtgggc attgtgacta ccac                                              24


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
tgctgctcca ctcacgtcg                                                    19


