                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
       GAERTIG, Jacek
       WLOGA, Dorota
       AKELLA, Shilpa
 
<120>  ALPHA TUBULIN ACETYL TRANSFERASE

<130>  235.01330201

<150>  US 61/325,680
<151>  2010-04-19

<150>  US 61/327,462
<151>  2010-04-23

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  1
attgtgggcc ctagcatttc tggaagattc attc                                   34


<210>  2
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  2
aatacccggg caattgaatg tatgtgctga t                                      31


<210>  3
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  3
aaattctgca gttagtactt tagaagtgat gct                                    33


<210>  4
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  4
aaattgagct ctctagttga ctatattatg cattc                                  35


<210>  5
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  5
atattacgcg tcatggagtt taacttcatc attaatag                               38


<210>  6
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  6
atattggatc ctcatttttt gtagtatgtg tagtgat                                37


<210>  7
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  synthetic morpholino targeting MEC-17 mRNA

<400>  7
cattcaggtc gtaagggaaa tccat                                             25


<210>  8
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  synthetic morpholino targeting MEC-17 mRNA

<400>  8
agagaaagct attttacccg ttctg                                             25


<210>  9
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  synthetic negative control morpholino

<400>  9
cattgacgtc ctaaggcaaa tgcat                                             25


<210>  10
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  10
ggtcggaaag cgcatgggag                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  11
gaagtcgaag agctctgagc c                                                 21


<210>  12
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  12
gattcgctgg agatgatg                                                     18


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  13
gtctttctgt cccataccaa                                                   20


<210>  14
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  14
attatgttta aaccaagctc gagttctcca tc                                     32


<210>  15
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  15
aattatgatc acagcaaagg attcaaggct c                                      31


<210>  16
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  16
ataatgttta aaccggcgag aagagctatc aa                                     32


<210>  17
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  17
aatttggaga actcgagctt ggcc                                              24


<210>  18
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  synthetic siRNA targeting MEC-17

<400>  18
guagcuaggu cccgauaua                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  synthetic siRNA targeting MEC-17

<400>  19
gaguauagcu agaucccuu                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  synthetic siRNA targeting MEC-17

<400>  20
gggaaacuca ccagaacga                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  synthetic siRNA targeting MEC-17

<400>  21
cuugugagau ugucgagau                                                    19


<210>  22
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  synthetic negative control siRNA

<400>  22
gcugacccug aaguucaucu gtt                                               23


<210>  23
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  23
aaattgagct ctggagttcc cgttcgatgt ggat                                   34


<210>  24
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  24
aatagaattc ccgcggacta agctttggcc atggttacc                              39


<210>  25
<211>  191
<212>  PRT
<213>  Drosophila melanogaster

<400>  25

Met Val Glu Phe Arg Phe Asp Ile Lys Pro Leu Phe Ala Gln Pro Ile 
1               5                   10                  15      


Ile Lys Val Thr Ser Asn Leu Leu Pro Asn Thr Phe Arg Gly Asp Arg 
            20                  25                  30          


Arg Gln Cys Leu Asp Ala Thr Ser Lys Met Thr Glu Ile Ile Asp Gln 
        35                  40                  45              


Leu Gly Gln Leu Ser Ala Thr Ser Gln Gly Leu Ser Lys Pro Val Thr 
    50                  55                  60                  


Thr Ala Gln Arg Leu Arg Met Ser Asp Asn Gln Thr Ile Tyr Leu Leu 
65                  70                  75                  80  


Ala Asp Asn Glu Ala Gly His Asn Gly Ala Val Leu Gly Leu Leu Lys 
                85                  90                  95      


Val Gly Thr Lys Asn Leu Tyr Leu Phe Asp Glu Ala Gly Lys Thr Arg 
            100                 105                 110         


Met Val Glu Gln Thr Pro Ser Ile Leu Asp Phe Tyr Val His Glu Ser 
        115                 120                 125             


Arg Gln Arg Ala Gly Leu Gly Lys Arg Leu Phe Gln Thr Met Leu Asn 
    130                 135                 140                 


Glu Glu Gln Trp Thr Ala Arg Lys Cys Ser Val Asp Arg Pro Ser Glu 
145                 150                 155                 160 


Lys Leu Leu Ser Phe Leu Ser Lys His Tyr Gly Leu Lys Arg Ile Ile 
                165                 170                 175     


Pro Gln Ala Asn Asn Phe Val Leu Tyr Glu Gly Phe Phe Asn Asp 
            180                 185                 190     


<210>  26
<211>  198
<212>  PRT
<213>  Drosophila melanogaster

<400>  26

Met Val Glu Phe Ala Phe Asp Ile Lys His Leu Phe Pro Gln Ser Ile 
1               5                   10                  15      


Ile Arg Val Gln Ala His Ser Leu Arg Pro Lys Val Thr Gln Cys Arg 
            20                  25                  30          


Arg Tyr Ala Gln Thr Glu Arg Gly Lys Ser Thr Met Thr Ser Cys Arg 
        35                  40                  45              


Leu Ser Glu Ile Leu Asn Ile Met Gly Lys Leu Ser Ala Asp Ala Gln 
    50                  55                  60                  


Gly Leu Cys His Ala Val Thr Thr Ala Gln Arg Leu Arg Met Ser Asp 
65                  70                  75                  80  


Asn Gln Thr Ile Tyr Leu Leu Ala Asp Asn Glu Ala Gly His Asn Gly 
                85                  90                  95      


Ala Val Leu Gly Leu Leu Lys Val Gly Thr Lys Asn Leu Tyr Leu Phe 
            100                 105                 110         


Asp Glu Ala Gly Lys Thr Arg Met Val Glu Gln Thr Pro Ser Ile Leu 
        115                 120                 125             


Asp Phe Tyr Val His Glu Ser Arg Gln Arg Ala Gly Leu Gly Lys Arg 
    130                 135                 140                 


Leu Phe Gln Thr Met Leu Asn Glu Glu Gln Trp Thr Ala Arg Lys Cys 
145                 150                 155                 160 


Ser Val Asp Arg Pro Ser Glu Lys Leu Leu Ser Phe Leu Ser Lys His 
                165                 170                 175     


Tyr Gly Leu Lys Arg Ile Ile Pro Gln Ala Asn Asn Phe Val Leu Tyr 
            180                 185                 190         


Glu Gly Phe Phe Asn Asp 
        195             


<210>  27
<211>  188
<212>  PRT
<213>  Trypanosome brucei

<400>  27

Met Thr His Asn Val Met Cys Asp Asp Val Leu Pro Gln Leu Asn Leu 
1               5                   10                  15      


Pro Asp Gly Val Thr Arg Trp Asn Ala Asn Leu Leu Glu Glu Glu Arg 
            20                  25                  30          


Arg Leu Arg Asn Ser Asp Gly His Ala Asp Arg Ile Ile Leu Thr Ile 
        35                  40                  45              


Asn Thr Leu Gly Lys Arg Ser Lys Glu Ala Gln Ser Leu Asn Thr Ile 
    50                  55                  60                  


Leu Thr Ser Val Pro Arg Leu Arg Glu Asn Arg Asp Ala Arg Leu Tyr 
65                  70                  75                  80  


Leu Leu Cys His Gly Gly Arg Gly Val Gly Ile Leu Lys Ile Gly Val 
                85                  90                  95      


Lys Arg Leu Phe Val Val Pro Pro Ser His Ala Gly Leu Met Glu Ile 
            100                 105                 110         


Glu Pro Val Cys Val Leu Asp Phe Phe Val Asp Thr Ser Asn Gln Arg 
        115                 120                 125             


Gln Gly Tyr Gly Lys Ile Leu Phe Glu His Met Leu Ala Phe Glu Arg 
    130                 135                 140                 


Leu Ser Pro Gly Asp Val Ala Ile Asp Arg Pro Ser Val Lys Phe Leu 
145                 150                 155                 160 


Ala Phe Leu Arg Lys His Tyr Gly Leu Val Glu Tyr Thr Pro Gln Ser 
                165                 170                 175     


Asn Asn Phe Val Val Phe His Lys Tyr Phe Glu Arg 
            180                 185             


<210>  28
<211>  187
<212>  PRT
<213>  Trypanosoma cruzi

<400>  28

Met Ser Ser Thr Ser Gln Val Ala Leu Leu Pro Lys Leu Ser Leu Pro 
1               5                   10                  15      


Asp Gly Val Thr Val Trp Asp Gly Thr Ala Leu Glu Tyr Glu Arg Arg 
            20                  25                  30          


Cys Asn Asn Val Asp Glu His Ala Val His Leu Met Gln Thr Ile Asn 
        35                  40                  45              


Ile Leu Gly Ile Arg Ser Lys Glu Ala Gln Cys Leu Asn Thr Val Leu 
    50                  55                  60                  


Thr Ser Val Ala Arg Leu Arg Glu Asn Arg Gln Ala Arg Val Tyr Leu 
65                  70                  75                  80  


Leu Cys Gln Asp Gly Tyr Gly Val Gly Ile Leu Lys Met Gly Val Lys 
                85                  90                  95      


Lys Leu Phe Val Thr His Pro Ser Tyr Ser Ser Leu Val Glu Ile Asp 
            100                 105                 110         


Pro Leu Cys Val Leu Asp Phe Phe Val Asp Thr Ser Phe Gln Arg Lys 
        115                 120                 125             


Gly Phe Gly Lys Thr Leu Phe Asp Ala Met Leu Leu Asn Glu Gly Leu 
    130                 135                 140                 


Asn Pro Gly Glu Val Ala Ile Asp Arg Pro Ser Val Lys Phe Leu Ala 
145                 150                 155                 160 


Phe Leu Gln Lys Tyr Tyr Gly Leu Val Glu Tyr Thr Pro Gln Ser Asn 
                165                 170                 175     


Asn Phe Val Val Phe His Arg Tyr Phe Asp Lys 
            180                 185         


<210>  29
<211>  188
<212>  PRT
<213>  Xenopus tropicalis

<400>  29

Met Glu Phe Asp Phe Asp Val His Lys Ile Phe Leu Glu Pro Ile Thr 
1               5                   10                  15      


Lys Leu Asp Ser Ser Leu Ile Pro Ser Arg Arg Pro Leu Ile Ala Ser 
            20                  25                  30          


Ser Glu Ala Gln Lys Gln Ile Met Thr Val Ile Asp Glu Ile Gly Lys 
        35                  40                  45              


Ala Ser Ala Lys Ala Gln Arg Leu Pro Ala Pro Ile Thr Ser Ala Ser 
    50                  55                  60                  


Arg Met Gln Thr Asn Lys His His Leu Tyr Ile Leu Lys Asp Cys Thr 
65                  70                  75                  80  


Pro Lys Thr Ala Gly Arg Gly Ala Val Ile Gly Phe Leu Lys Val Gly 
                85                  90                  95      


Cys Lys Lys Leu Phe Val Leu Asp Gln Lys Gly Ser His Ile Glu Ala 
            100                 105                 110         


Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu Thr Leu Gln Arg 
        115                 120                 125             


His Gly Phe Gly Lys Glu Leu Phe Thr Phe Met Leu Lys Asn Glu Gln 
    130                 135                 140                 


Val Asp Val His His Leu Ala Ile Asp Arg Pro Ser Glu Lys Phe Leu 
145                 150                 155                 160 


Ser Phe Leu Arg Lys His Phe Asn Leu Trp Ser Thr Ile Pro Gln Val 
                165                 170                 175     


Asn Asn Phe Val Val Phe Asp Gly Phe Phe Arg Asp 
            180                 185             


<210>  30
<211>  188
<212>  PRT
<213>  Xenopus laevis

<400>  30

Met Glu Phe Glu Phe Asp Val His Lys Ile Phe Leu Glu Pro Ile Thr 
1               5                   10                  15      


Lys Leu Asp Asn Asn Leu Ile Pro Pro Arg Arg Pro Leu Ile Ser Ser 
            20                  25                  30          


Ser Glu Ala Gln Lys Gln Ile Met Thr Val Ile Asp Glu Ile Gly Lys 
        35                  40                  45              


Ala Ser Ala Lys Ala Gln Arg Leu Pro Ala Ser Ile Thr Ser Ala Ser 
    50                  55                  60                  


Arg Met Gln Ala Asn Lys His His Leu Tyr Ile Leu Lys Asp Cys Thr 
65                  70                  75                  80  


Pro Lys Thr Ala Gly Arg Gly Ala Val Ile Gly Phe Leu Lys Val Gly 
                85                  90                  95      


Tyr Lys Lys Leu Phe Ile Leu Asp Gln Lys Gly Ser His Ile Glu Ala 
            100                 105                 110         


Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu Ser Leu Gln Arg 
        115                 120                 125             


His Gly Phe Gly Lys Glu Leu Phe Ser Phe Met Leu Arg Asn Glu Gln 
    130                 135                 140                 


Val Asp Val Gln His Leu Ala Ile Asp Arg Pro Ser Glu Lys Phe Leu 
145                 150                 155                 160 


Ser Phe Leu Arg Lys His Phe Asn Leu Trp Ser Thr Ile Pro Gln Val 
                165                 170                 175     


Asn Asn Phe Val Val Phe Glu Gly Phe Phe Arg Asp 
            180                 185             


<210>  31
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


<210>  32
<211>  186
<212>  PRT
<213>  Danio rerio

<400>  32

Met Asp Phe Pro Tyr Asp Leu Asn Ala Leu Phe Pro Glu Arg Ile Ser 
1               5                   10                  15      


Val Leu Asp Ser Asn Leu Ser Ala Gly Arg Lys Ala His Gly Arg Pro 
            20                  25                  30          


Asp Pro Leu Pro Gln Val Thr Thr Val Ile Asp Glu Leu Gly Lys Ala 
        35                  40                  45              


Ser Ser Lys Ala Gln Gln Leu Pro Ala Pro Ile Thr Ser Ala Ala Lys 
    50                  55                  60                  


Leu Gln Ala Asn Arg His His Leu Tyr Leu Leu Lys Asp Gly Glu Gln 
65                  70                  75                  80  


Asn Gly Gly Arg Gly Val Ile Val Gly Phe Leu Lys Val Gly Tyr Lys 
                85                  90                  95      


Lys Leu Phe Leu Leu Asp Gln Arg Gly Ala His Leu Glu Thr Glu Pro 
            100                 105                 110         


Leu Cys Val Leu Asp Phe Tyr Val Thr Glu Thr Leu Gln Arg His Gly 
        115                 120                 125             


Tyr Gly Ser Glu Leu Phe Asp Phe Met Leu Lys His Lys Gln Val Glu 
    130                 135                 140                 


Pro Ala Gln Met Ala Tyr Asp Arg Pro Ser Pro Lys Phe Leu Ser Phe 
145                 150                 155                 160 


Leu Glu Lys Arg Tyr Asp Leu Arg Asn Ser Val Pro Gln Val Asn Asn 
                165                 170                 175     


Phe Val Val Phe Ala Gly Phe Phe Gln Ser 
            180                 185     


<210>  33
<211>  185
<212>  PRT
<213>  Ciona intestinalis

<400>  33

Met Glu Phe Asp Phe Asn Ile Asn His Leu Phe Pro Asp Lys Ile Thr 
1               5                   10                  15      


Leu Val Gly Glu Asn Ser Ser Tyr Arg Lys His Ala Asn Ser Lys Ile 
            20                  25                  30          


Leu Gln Arg Asn Leu Gln Ile Val Ile Glu Val Leu Gly Gln Arg Ser 
        35                  40                  45              


Ala Arg Ala Gln Gln Leu Thr Gly Ser Ile Thr Thr Leu Leu Lys Ser 
    50                  55                  60                  


Gln Leu Asn Asn Gln Arg Ile Tyr Val Leu Lys Glu Ala Asn Ala Asn 
65                  70                  75                  80  


Asn Gly Leu Gly Cys Val Ile Gly Phe Leu Lys Thr Gly Lys Lys Arg 
                85                  90                  95      


Leu Phe Val Leu Asp Arg Asp Gly Asn His Asn Glu Met Asn Pro Leu 
            100                 105                 110         


Cys Val Leu Asp Phe Tyr Val His Glu Ser Gln Gln Arg Lys Gly Cys 
        115                 120                 125             


Gly Leu Cys Leu Phe Lys His Met Leu His Val Glu Gly Val Lys Ala 
    130                 135                 140                 


Ser His Leu Ala Ile Asp Arg Pro Ser His Lys Phe Ile Ser Phe Leu 
145                 150                 155                 160 


Lys Lys His Phe Ser Leu Trp Ala Thr Val Pro Gln Val Asn Asn Phe 
                165                 170                 175     


Val Ile Phe Asp Gly Phe Phe Lys Asn 
            180                 185 


<210>  34
<211>  180
<212>  PRT
<213>  Tetrahymena thermophila

<400>  34

Met Glu Phe Asn Phe Ile Ile Asn Lys Leu Val Gln Leu Asp Gln Gln 
1               5                   10                  15      


Gly Leu Gly Val Tyr Ile Pro Arg Ala Ser Arg Ser Lys Val Ser Ser 
            20                  25                  30          


Gln Gln Glu Gln Gln Leu Gly Gln Val Leu Asn Thr Met Gly Glu Arg 
        35                  40                  45              


Ser Ala Ile Ala Gln Gly Leu Lys Gln Val Ile Thr Asn Tyr Asp Lys 
    50                  55                  60                  


Val Gln Gly Thr Asp Gln Arg Val Tyr Ile Val Ala Glu Gly Arg Thr 
65                  70                  75                  80  


Cys Gln Gly Phe Leu Lys Val Gly Gln Lys Asn Leu Phe Tyr Arg Asp 
                85                  90                  95      


Met Met Gly Asn Ile Lys Glu Ile Lys Pro Leu Cys Val Leu Asp Phe 
            100                 105                 110         


Tyr Val His Glu Ser Cys Gln Arg Gln Gly Tyr Gly Lys Leu Leu Phe 
        115                 120                 125             


Glu Tyr Met Ile Gln Cys Glu Gln Thr Ser Pro Glu Lys Leu Ala Tyr 
    130                 135                 140                 


Asp Arg Pro Ser Pro Lys Leu Ile Ala Phe Leu Lys Lys His Tyr Asn 
145                 150                 155                 160 


Leu Val Lys Tyr Ile Ala Gln Asn Asn Asn Phe Val Val Phe Asp Gln 
                165                 170                 175     


Tyr Phe Arg Ser 
            180 


<210>  35
<211>  174
<212>  PRT
<213>  Paramecium tetraurelia

<400>  35

Met Gln Phe Gln Phe Pro Leu Gln Lys Ala Leu Gln Thr Ser Gln Asn 
1               5                   10                  15      


Gly Ile Ser Val Ile Ser Ala Ser Asn Ser Arg Arg Asn Cys Tyr Leu 
            20                  25                  30          


Asp Glu Val Ile Asp Arg Met Gly Glu Ala Ser Ala Ile Ala Gln Gln 
        35                  40                  45              


Leu Lys Gln Ile Ile Thr Thr Ala Ser Lys Phe Tyr Gly Ser Asp Gln 
    50                  55                  60                  


Arg Ile Tyr Leu Lys Ala Asp Gly Lys Asn Cys Leu Gly Leu Leu Lys 
65                  70                  75                  80  


Val Gly Lys Lys Asn Leu Phe Tyr Arg Asp Tyr Ser Gly Ser Ile Lys 
                85                  90                  95      


Glu Met Gln Pro Leu Cys Val Leu Asp Phe Tyr Val His Glu Ser Val 
            100                 105                 110         


Gln Arg Met Gly Val Gly Lys Glu Leu Phe Glu Glu Met Leu Lys Ser 
        115                 120                 125             


Glu Gln Ile Lys Pro Glu Lys Leu Ala Tyr Asp Arg Pro Ser Gln Lys 
    130                 135                 140                 


Leu Ile Gly Phe Leu Asn Lys His Tyr Asn Leu Asn Gln Tyr Val Pro 
145                 150                 155                 160 


Gln Asn Asn Asn Phe Val Ile Phe Asn Gln Tyr Phe Gly Gln 
                165                 170                 


<210>  36
<211>  179
<212>  PRT
<213>  Caenorhabditis elegans

<400>  36

Met Gln Val Asp Ala Asp Leu Arg Pro Ile Leu Gly Pro Gln Leu Val 
1               5                   10                  15      


Arg Leu Asp Pro Met Arg Val Lys Gln Leu Gln Asp Pro Ile Val Tyr 
            20                  25                  30          


Glu Ala Ile Asp Asn Leu Ala Lys Leu Ser Ala His Cys Leu Gln Leu 
        35                  40                  45              


Arg Thr Pro Leu Thr Thr Cys Glu Lys Leu Ile Asn Ser Asp Ser Thr 
    50                  55                  60                  


Leu Tyr Leu Ser Trp Lys Tyr Asp Glu Glu Glu Lys Val Ser Arg Leu 
65                  70                  75                  80  


Met Gly Phe Ala Lys Val Gly Arg Lys Lys Leu Phe Leu Tyr Asp Ser 
                85                  90                  95      


Gln Met Gln Thr Tyr Glu Gly Glu Ile Leu Cys Leu Leu Asp Phe Tyr 
            100                 105                 110         


Val His Phe Ser Cys Gln Arg Gln Gly Val Gly Gln Gln Ile Leu Asp 
        115                 120                 125             


Tyr Met Phe Ser Gln Glu His Thr Glu Pro Tyr Gln Leu Ala Leu Asp 
    130                 135                 140                 


Asn Pro Ser Val Thr Leu Leu Gly Phe Met Ser Gln Lys Tyr Gly Leu 
145                 150                 155                 160 


Ile Lys Pro Val Trp Gln Asn Thr Asn Phe Val Val Phe Glu Glu Leu 
                165                 170                 175     


Phe Leu Ala 
            


<210>  37
<211>  179
<212>  PRT
<213>  Giardia lamblia

<400>  37

Met Gln Phe Gly Cys Asn Val Ala Glu Ala Phe Gly Leu Arg Arg Ser 
1               5                   10                  15      


Gly Val Val Leu Leu Thr Asp Gln Ser Leu Arg Ser Met Pro Leu Ser 
            20                  25                  30          


Gln Gln Lys Lys Val Glu Ile Ile Leu Asp Gly Met Gly Arg Gly Ser 
        35                  40                  45              


Gln Ala Ala Gln Gly Leu Pro Ser Pro Ile Thr Ser Leu Ala Phe Ile 
    50                  55                  60                  


Arg Asp Ser His His Phe Leu Phe Leu Ala Val Asp Glu Asp Gln Cys 
65                  70                  75                  80  


Leu Gly Ile Leu Lys Gly Gly Ile Lys His Leu Phe Met Leu Asp Ser 
                85                  90                  95      


Gln Asn Glu Thr His Glu Met Asp Ala Met Cys Cys Leu Asp Phe Tyr 
            100                 105                 110         


Thr His Glu Thr Val Gln Arg Arg Gly Ile Gly Thr Arg Leu Phe Arg 
        115                 120                 125             


Ala Met Glu Leu His Thr His Ile Ser Ala Gln Gly Trp Ala Phe Asp 
    130                 135                 140                 


Arg Pro Ser Pro Lys Leu Leu Ala Phe Leu Ser Lys Val Tyr Asp Met 
145                 150                 155                 160 


His Asp Phe Lys Ala Gln Pro Asn Asn Phe Leu Met Leu Asp Ala Ser 
                165                 170                 175     


Ile Arg Leu 
            


<210>  38
<211>  183
<212>  PRT
<213>  Caenorhabditis elegans

<400>  38

Met Glu Ile Ala Phe Asp Leu Ser Thr Ile Phe Thr Asp Asn Ile Gln 
1               5                   10                  15      


Arg Leu Thr Arg Thr Asp Leu Leu Lys Tyr Gly Pro Lys Arg Tyr Trp 
            20                  25                  30          


Ala Val Ala Gln Ser Ile Asp Cys Leu Gly Glu Met Ser Ser Lys Phe 
        35                  40                  45              


His Gly Trp Lys Arg Val Ile Thr Met Tyr Asp Lys Ile Val Asp His 
    50                  55                  60                  


Asp Glu Glu Gln Thr Thr Tyr Ile Met Trp Glu Lys Val Asn Gly Ser 
65                  70                  75                  80  


Lys Ser Ile Leu Lys Gly Leu Leu Arg Val Gly Tyr Lys Thr Leu Tyr 
                85                  90                  95      


Leu Thr Asp Asn Glu Gln Asn Gln Tyr Met Glu Lys Ala Met Cys Ile 
            100                 105                 110         


Leu Asp Phe Phe Val Val Pro Thr Glu Gln Arg Ser Gly Asn Gly Phe 
        115                 120                 125             


Lys Met Phe Asp Glu Met Leu Lys Ala Glu Asn Val Thr Val Asp Gln 
    130                 135                 140                 


Cys Ala Phe Asp Lys Pro Ser Ala Ala Leu Gln Gln Phe Leu Glu Lys 
145                 150                 155                 160 


Tyr Tyr Asp Arg Lys Asp Leu Val Trp Gln Ser Asn Lys Tyr Ala Leu 
                165                 170                 175     


Cys Ser Asn Phe Phe Ile Gly 
            180             


<210>  39
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  39
acgataaggt ataaggaaca g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide primer

<400>  40
aagttatcta tcttatccag g                                                 21


<210>  41
<211>  262
<212>  PRT
<213>  Caenorhabditis elegans

<400>  41

Met Gln Val Asp Ala Asp Leu Arg Pro Ile Leu Gly Pro Gln Leu Val 
1               5                   10                  15      


Arg Leu Asp Pro Met Arg Val Lys Gln Leu Gln Asp Pro Ile Val Tyr 
            20                  25                  30          


Glu Ala Ile Asp Asn Leu Ala Lys Leu Ser Ala His Cys Leu Gln Leu 
        35                  40                  45              


Arg Thr Pro Leu Thr Thr Cys Glu Lys Leu Ile Asn Ser Asp Ser Thr 
    50                  55                  60                  


Leu Tyr Leu Ser Trp Lys Tyr Asp Glu Glu Glu Lys Val Ser Arg Leu 
65                  70                  75                  80  


Met Gly Phe Ala Lys Val Gly Arg Lys Lys Leu Phe Leu Tyr Asp Ser 
                85                  90                  95      


Gln Met Gln Thr Tyr Glu Gly Glu Ile Leu Cys Leu Leu Asp Phe Tyr 
            100                 105                 110         


Val His Phe Ser Cys Gln Arg Gln Gly Val Gly Gln Gln Ile Leu Asp 
        115                 120                 125             


Tyr Met Phe Ser Gln Glu His Thr Glu Pro Tyr Gln Leu Ala Leu Asp 
    130                 135                 140                 


Asn Pro Ser Val Thr Leu Leu Gly Phe Met Ser Gln Lys Tyr Gly Leu 
145                 150                 155                 160 


Ile Lys Pro Val Trp Gln Asn Thr Asn Phe Val Val Phe Glu Glu Leu 
                165                 170                 175     


Phe Leu Ala Leu Ser Ala Glu Asn Gly Ile Glu Lys Pro Pro Pro Asp 
            180                 185                 190         


Gly Trp Arg Arg Pro Met Thr Pro Arg Arg Leu Gly Thr Gly Met Thr 
        195                 200                 205             


Asp Thr Arg Trp Leu Gln His Ala Val Ser Gly His Gln Ser Lys Gly 
    210                 215                 220                 


Asn Ala Met Ala Ala Pro Val Asp Ala Asp Met Thr Pro Gln Gly Ala 
225                 230                 235                 240 


Leu Ser Asn Arg Ala His Gln Ala Lys Ala Arg Lys Ala His Ile Leu 
                245                 250                 255     


Ser Ser Lys Pro Leu Trp 
            260         


<210>  42
<211>  263
<212>  PRT
<213>  Caenorhabditis elegans

<400>  42

Met Glu Ile Ala Phe Asp Leu Ser Thr Ile Phe Thr Asp Asn Ile Gln 
1               5                   10                  15      


Arg Leu Thr Arg Thr Asp Leu Leu Lys Tyr Gly Pro Lys Arg Tyr Trp 
            20                  25                  30          


Ala Val Ala Gln Ser Ile Asp Cys Leu Gly Glu Met Ser Ser Lys Phe 
        35                  40                  45              


His Gly Trp Lys Arg Val Ile Thr Met Tyr Asp Lys Ile Val Asp His 
    50                  55                  60                  


Asp Glu Glu Gln Thr Thr Tyr Ile Met Trp Glu Lys Val Asn Gly Ser 
65                  70                  75                  80  


Lys Ser Ile Leu Lys Gly Leu Leu Arg Val Gly Tyr Lys Thr Leu Tyr 
                85                  90                  95      


Leu Thr Asp Asn Glu Gln Asn Gln Tyr Met Glu Lys Ala Met Cys Ile 
            100                 105                 110         


Leu Asp Phe Phe Val Val Pro Thr Glu Gln Arg Ser Gly Asn Gly Phe 
        115                 120                 125             


Lys Met Phe Asp Glu Met Leu Lys Ala Glu Asn Val Thr Val Asp Gln 
    130                 135                 140                 


Cys Ala Phe Asp Lys Pro Ser Ala Ala Leu Gln Gln Phe Leu Glu Lys 
145                 150                 155                 160 


Tyr Tyr Asp Arg Lys Asp Leu Val Trp Gln Ser Asn Lys Tyr Ala Leu 
                165                 170                 175     


Cys Ser Asn Phe Phe Ile Gly Arg His Pro Thr Val Pro Phe Thr Pro 
            180                 185                 190         


Arg Gln Thr Lys Arg Ala Ser Arg Ala Ser Ser Ala Val Ser Ser His 
        195                 200                 205             


Ala Ser Ser Arg Asn Thr Ser Pro Ile Gly Arg Asn Arg Pro Arg His 
    210                 215                 220                 


Asp Ser Val Ala Asp Leu Met Arg Gln Asp Met Leu Ala Gly Val Arg 
225                 230                 235                 240 


Ala Glu Val Asp Pro Asn Ser Pro Thr Gly Leu Lys Asn Ala Arg Asp 
                245                 250                 255     


Phe Gly His Arg Arg Ile Trp 
            260             


<210>  43
<211>  410
<212>  PRT
<213>  Ciona intestinalis

<400>  43

Met Glu Phe Asp Phe Asn Ile Asn His Leu Phe Pro Asp Lys Ile Thr 
1               5                   10                  15      


Leu Val Gly Glu Asn Ser Ser Tyr Arg Lys His Ala Asn Ser Lys Ile 
            20                  25                  30          


Leu Gln Arg Asn Leu Gln Ile Val Ile Glu Val Leu Gly Gln Arg Ser 
        35                  40                  45              


Ala Arg Ala Gln Gln Leu Thr Gly Ser Ile Thr Thr Leu Leu Lys Ser 
    50                  55                  60                  


Gln Leu Asn Asn Gln Arg Ile Tyr Val Leu Lys Glu Ala Asn Ala Asn 
65                  70                  75                  80  


Asn Gly Leu Gly Cys Val Ile Gly Phe Leu Lys Thr Gly Lys Lys Arg 
                85                  90                  95      


Leu Phe Val Leu Asp Arg Asp Gly Asn His Asn Glu Met Asn Pro Leu 
            100                 105                 110         


Cys Val Leu Asp Phe Tyr Val His Glu Ser Gln Gln Arg Lys Gly Cys 
        115                 120                 125             


Gly Leu Cys Leu Phe Lys His Met Leu His Val Glu Gly Val Lys Ala 
    130                 135                 140                 


Ser His Leu Ala Ile Asp Arg Pro Ser His Lys Phe Ile Ser Phe Leu 
145                 150                 155                 160 


Lys Lys His Phe Ser Leu Trp Ala Thr Val Pro Gln Val Asn Asn Phe 
                165                 170                 175     


Val Ile Phe Asp Gly Phe Phe Lys Asn Arg Ser Asp Thr Val Arg Asn 
            180                 185                 190         


Asn Asn Ala Lys Ser Glu Trp Asn Asn Arg Gln Phe Arg Pro Leu Ser 
        195                 200                 205             


Arg Ala Val Ser Asp Asp Ile Ile Lys Arg Asn Arg Phe Ser His Asp 
    210                 215                 220                 


Val Pro Asn Lys Val Asn Gly Leu Pro Pro Leu Pro Pro Asn Arg Arg 
225                 230                 235                 240 


Asp Arg Tyr Gly Asp Asn Asp Val Val Thr Asn Pro Tyr Arg Arg Asn 
                245                 250                 255     


Ser Thr Asn Gln Asn Gly His Val Lys Gly Asp Val Leu Gln Gly Ser 
            260                 265                 270         


His Met Ala Asp Lys Lys Asp Ile Gly Glu Glu Arg Ala Lys Asp Asn 
        275                 280                 285             


Ala Leu Pro Gly Ile Ala Thr Asn Gln Leu Glu Glu Ser Arg Val Gln 
    290                 295                 300                 


Thr Asn Pro Gln Glu Val Thr Glu Asn Ala Tyr Asn Gly Met Asn Lys 
305                 310                 315                 320 


His Ser Ser Pro Val Asp Gln Leu Lys Cys Asn Ser Leu Ser Gln Asp 
                325                 330                 335     


Gln Lys Ser Ser Pro Lys Ile Ala Arg Lys Pro Ala Thr Pro Pro His 
            340                 345                 350         


Leu Lys Pro Ser Ser Ile Ile Asp Glu Leu Lys Ala Lys Asp Ala Ala 
        355                 360                 365             


Tyr Leu Ser Asn Arg Asn Leu Ser Thr Gln Asn Gln Ser Arg Leu Trp 
    370                 375                 380                 


Tyr Gln Arg Gln Leu Gln Gly Thr Arg Ser Ser Trp Asn Val Leu Gly 
385                 390                 395                 400 


Val Pro Thr Arg Pro Phe Trp Asn Ala Gln 
                405                 410 


<210>  44
<211>  461
<212>  PRT
<213>  Drosophila melanogaster

<400>  44

Met Val Glu Phe Arg Phe Asp Ile Lys Pro Leu Phe Ala Gln Pro Ile 
1               5                   10                  15      


Ile Lys Val Thr Ser Asn Leu Leu Pro Asn Thr Phe Arg Gly Asp Arg 
            20                  25                  30          


Arg Gln Cys Leu Asp Ala Thr Ser Lys Met Thr Glu Ile Ile Asp Gln 
        35                  40                  45              


Leu Gly Gln Leu Ser Ala Thr Ser Gln Gly Leu Ser Lys Pro Val Thr 
    50                  55                  60                  


Thr Ala Gln Arg Leu Arg Met Ser Asp Asn Gln Thr Ile Tyr Leu Leu 
65                  70                  75                  80  


Ala Asp Asn Glu Ala Gly His Asn Gly Ala Val Leu Gly Leu Leu Lys 
                85                  90                  95      


Val Gly Thr Lys Asn Leu Tyr Leu Phe Asp Glu Ala Gly Lys Thr Arg 
            100                 105                 110         


Met Val Glu Gln Thr Pro Ser Ile Leu Asp Phe Tyr Val His Glu Ser 
        115                 120                 125             


Arg Gln Arg Ala Gly Leu Gly Lys Arg Leu Phe Gln Thr Met Leu Asn 
    130                 135                 140                 


Glu Glu Gln Trp Thr Ala Arg Lys Cys Ser Val Asp Arg Pro Ser Glu 
145                 150                 155                 160 


Lys Leu Leu Ser Phe Leu Ser Lys His Tyr Gly Leu Lys Arg Ile Ile 
                165                 170                 175     


Pro Gln Ala Asn Asn Phe Val Leu Tyr Glu Gly Phe Phe Asn Asp Gly 
            180                 185                 190         


Glu Ser Gly Asn Gly Gly Gly Asn Gly His Ala Asn Gly Thr Pro Asn 
        195                 200                 205             


Gly Leu His Ile Thr Asn Ser Pro Asn Thr His Leu Phe Gly Ala Thr 
    210                 215                 220                 


Tyr Leu Gly Glu Asp Ser Asn Gln Arg Arg Gly Ser Gln Gln Gln Thr 
225                 230                 235                 240 


Thr Pro Asn Ala Arg Leu Gln Gln Ile Thr Gln Ile Ser Pro Ser Gly 
                245                 250                 255     


Arg Tyr Gly Ala Lys Arg Pro Thr Cys Ser Met Ala Glu Ile Ile His 
            260                 265                 270         


Ala Gly Asn Ser Lys Gly Gly Asn Gly Asn Gly Ser Ala Glu Ala Asn 
        275                 280                 285             


Ser Gly Asn Gly Asn His Asp Ile Pro Glu Ile Ala Glu Gln Leu Gln 
    290                 295                 300                 


Arg Gln Ser Leu Ala Asp Leu Glu Ala Asn Ser Tyr Glu Pro Glu Pro 
305                 310                 315                 320 


Glu Val Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
                325                 330                 335     


Glu Val Ile Thr Pro Pro Ser Pro Pro Pro Lys Ser His Thr Pro Thr 
            340                 345                 350         


Pro Pro Ser Val Arg Ser Pro Glu Val Ala Glu Ser Ile Val Gly Asp 
        355                 360                 365             


Asn Arg Arg Ala Pro Ala Phe Gln Leu Ser Lys Gln His Thr Gly Met 
    370                 375                 380                 


Lys Asn Arg Ser Phe Gly Val Gly Met Ala Val Met Pro Ser Ser Lys 
385                 390                 395                 400 


Met Glu Phe Asp Gln Met Glu Arg Glu Asp Phe Gly Val Val Lys Ile 
                405                 410                 415     


Asn Arg Pro Pro Gly His Glu Val Thr Ser Pro Gly Gln Asp Asn Thr 
            420                 425                 430         


Asp Ala Met Ser Thr Val Ser Ser Gly Gly Gly Gly Leu Thr Asp Gln 
        435                 440                 445             


Gly Tyr Tyr Asp Leu Lys Phe Tyr His Asn Lys Leu Trp 
    450                 455                 460     


<210>  45
<211>  287
<212>  PRT
<213>  Drosophila melanogaster

<400>  45

Met Val Glu Phe Ala Phe Asp Ile Lys His Leu Phe Pro Gln Ser Ile 
1               5                   10                  15      


Ile Arg Val Gln Ala His Ser Leu Arg Pro Lys Val Thr Gln Cys Arg 
            20                  25                  30          


Arg Tyr Ala Gln Thr Glu Arg Gly Lys Ser Thr Met Thr Ser Cys Arg 
        35                  40                  45              


Leu Ser Glu Ile Leu Asn Ile Met Gly Lys Leu Ser Ala Asp Ala Gln 
    50                  55                  60                  


Gly Leu Cys His Ala Val Thr Ser Ala Asp Lys Leu Ala Ser Asp Gln 
65                  70                  75                  80  


Val Val Tyr Leu Met Ala Asp Lys Ala Ala Gly His Trp Glu Ile Thr 
                85                  90                  95      


Gly Leu Leu Lys Val Gly Thr Lys Asp Leu Phe Val Phe Asp Gln Gly 
            100                 105                 110         


Gly Cys Tyr Arg Arg Leu Asn Gln Thr Pro Ala Ile Leu Asp Phe Tyr 
        115                 120                 125             


Val His Glu Ser Arg Gln Arg Cys Gly Gln Gly Lys Leu Leu Phe Glu 
    130                 135                 140                 


Trp Met Leu Glu Lys Gln Gly Trp Ser Ala His Lys Cys Thr Val Asp 
145                 150                 155                 160 


Arg Pro Ser Asn Lys Met Leu Ala Phe Met Ala Lys His Tyr Gly Leu 
                165                 170                 175     


Val Arg Thr Ile Pro Gln Gly Asn Asn Phe Val Leu Tyr Glu Gly Phe 
            180                 185                 190         


Phe Asp Asp Pro Ile Thr Thr Cys Lys Ser Ala Ser Gly Leu Gln Ala 
        195                 200                 205             


Thr Gly Ser Gly Cys Arg Ser Arg Ser Gln Gly His Tyr Val Arg Gln 
    210                 215                 220                 


Glu Gln Asp Gln Ala Gln Ile Lys His Gly Gln Ala Asn Arg Asn Thr 
225                 230                 235                 240 


Val Gln Asn Asp Ala Asn Ser Gly Pro Phe Arg Gln Asp Gln Lys Ile 
                245                 250                 255     


Val Val Gly Thr Ser Ile Tyr Arg Arg Arg Trp Lys Ser Pro Arg Thr 
            260                 265                 270         


Leu Ala Arg Ala Gly Cys Arg Glu Val Ser Gly Gly Arg Arg Phe 
        275                 280                 285         


<210>  46
<211>  297
<212>  PRT
<213>  Danio rerio

<400>  46

Met Asp Phe Pro Tyr Asp Leu Asn Ala Leu Phe Pro Glu Arg Ile Ser 
1               5                   10                  15      


Val Leu Asp Ser Asn Leu Ser Ala Gly Arg Lys Ala His Gly Arg Pro 
            20                  25                  30          


Asp Pro Leu Pro Gln Val Thr Thr Val Ile Asp Glu Leu Gly Lys Ala 
        35                  40                  45              


Ser Ser Lys Ala Gln Gln Leu Pro Ala Pro Ile Thr Ser Ala Ala Lys 
    50                  55                  60                  


Leu Gln Ala Asn Arg His His Leu Tyr Leu Leu Lys Asp Gly Glu Gln 
65                  70                  75                  80  


Asn Gly Gly Arg Gly Val Ile Val Gly Phe Leu Lys Val Gly Tyr Lys 
                85                  90                  95      


Lys Leu Phe Leu Leu Asp Gln Arg Gly Ala His Leu Glu Thr Glu Pro 
            100                 105                 110         


Leu Cys Val Leu Asp Phe Tyr Val Thr Glu Thr Leu Gln Arg His Gly 
        115                 120                 125             


Tyr Gly Ser Glu Leu Phe Asp Phe Met Leu Lys His Lys Gln Val Glu 
    130                 135                 140                 


Pro Ala Gln Met Ala Tyr Asp Arg Pro Ser Pro Lys Phe Leu Ser Phe 
145                 150                 155                 160 


Leu Glu Lys Arg Tyr Asp Leu Arg Asn Ser Val Pro Gln Val Asn Asn 
                165                 170                 175     


Phe Val Val Phe Ala Gly Phe Phe Gln Ser Arg Ser Ala Val Gln Leu 
            180                 185                 190         


Arg Lys Val Pro Pro Arg Lys Pro Glu Gly Glu Ile Lys Pro Tyr Ser 
        195                 200                 205             


Leu Met Glu Arg Glu Val Val Arg Glu Glu Gln Arg Val Leu Pro Trp 
    210                 215                 220                 


Pro Phe Val Arg Pro Gly Gly Pro Pro His Ser Pro Pro Leu Leu Pro 
225                 230                 235                 240 


Ser Ser Pro Gln Ser Arg Ser Leu Ser Val Gly Ser Ser Pro Ser Arg 
                245                 250                 255     


Ala Pro Leu Arg Pro Ala Ala Ala Thr Val Leu Gln Gln Gly Gln Thr 
            260                 265                 270         


Pro Ser Ser Pro Leu Asn Asp Ser Cys Arg Ala Lys Arg Thr Ser Ser 
        275                 280                 285             


Leu Asn Arg Ser Arg Leu Ser Phe His 
    290                 295         


<210>  47
<211>  362
<212>  PRT
<213>  Giardia lamblia

<400>  47

Met Gln Phe Gly Cys Asn Val Ala Glu Ala Phe Gly Leu Arg Arg Ser 
1               5                   10                  15      


Gly Val Val Leu Leu Thr Asp Gln Ser Leu Arg Ser Met Pro Leu Ser 
            20                  25                  30          


Gln Gln Lys Lys Val Glu Ile Ile Leu Asp Gly Met Gly Arg Gly Ser 
        35                  40                  45              


Gln Ala Ala Gln Gly Leu Pro Ser Pro Ile Thr Ser Leu Ala Phe Ile 
    50                  55                  60                  


Arg Asp Ser His His Phe Leu Phe Leu Ala Val Asp Glu Asp Gln Cys 
65                  70                  75                  80  


Leu Gly Ile Leu Lys Gly Gly Ile Lys His Leu Phe Met Leu Asp Ser 
                85                  90                  95      


Gln Asn Glu Thr His Glu Met Asp Ala Met Cys Cys Leu Asp Phe Tyr 
            100                 105                 110         


Thr His Glu Thr Val Gln Arg Arg Gly Ile Gly Thr Arg Leu Phe Arg 
        115                 120                 125             


Ala Met Glu Leu His Thr His Ile Ser Ala Gln Gly Trp Ala Phe Asp 
    130                 135                 140                 


Arg Pro Ser Pro Lys Leu Leu Ala Phe Leu Ser Lys Val Tyr Asp Met 
145                 150                 155                 160 


His Asp Phe Lys Ala Gln Pro Asn Asn Phe Leu Met Leu Asp Ala Ser 
                165                 170                 175     


Ile Arg Leu Trp Gly Ala Glu Phe Lys Gln Tyr Arg Arg Ser Lys Lys 
            180                 185                 190         


His Tyr Ile Pro Asp Ala Tyr Leu Leu Pro Glu Thr Arg Glu Ser Glu 
        195                 200                 205             


Tyr Leu Gly Glu Ala Glu Leu Thr Lys Arg Thr Leu Ile Arg Lys Ser 
    210                 215                 220                 


Thr Ala Val Ile Pro Gln Thr Lys Thr Thr Gln Ser Glu Asp Ala Pro 
225                 230                 235                 240 


Ala Arg Ala Leu Thr Ala Asp Glu Leu Leu Ser Lys Arg Ser Val Val 
                245                 250                 255     


Leu Pro Thr Ala Ser Arg Thr Pro Ser Leu Pro Asp Gln Pro Gln Ser 
            260                 265                 270         


Val Ala Ala Ala Tyr Met Asn Lys Arg Ile Glu Gly Ala Gly Pro Ser 
        275                 280                 285             


Phe Glu Gln Tyr Met Arg Asp His Tyr Gly Ala Lys Ser Leu Ile Val 
    290                 295                 300                 


Pro Ser Glu Ile Gln Thr Ser Leu Asn His Ser Lys Asp Ser Val Ser 
305                 310                 315                 320 


Gln Glu Asp Met Ile Gln Arg Gln Arg Gln Leu Asp Arg Met Ala Phe 
                325                 330                 335     


Thr Leu Ala Arg Glu Ala Asn Ala Arg Gly Ser Ile His Asn Thr Val 
            340                 345                 350         


Gly Arg Gly Val Ile Cys Gly Arg Arg Gly 
        355                 360         


<210>  48
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr Arg His Ser Arg 
        195                 200                 205             


Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala Arg Lys Leu Pro 
    210                 215                 220                 


Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser Ser Ser Asp Arg 
225                 230                 235                 240 


Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro Leu Asn Arg Ala 
                245                 250                 255     


Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro Arg Ser Ser Ser 
            260                 265                 270         


Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro Phe Val Pro Glu 
        275                 280                 285             


Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro His Pro Thr Ala 
    290                 295                 300                 


Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro Ala Gln Arg Arg 
305                 310                 315                 320 


Arg Thr Arg 
            


<210>  49
<211>  184
<212>  PRT
<213>  Micromonas sp. RCC299

<400>  49

Met Gln His Pro Arg Gly Val Ala Gly Leu Thr Pro Gly Gly Val Ser 
1               5                   10                  15      


Val Trp Thr Arg Asp Ala Ile Val Arg Leu Pro Pro Asp Glu Tyr Arg 
            20                  25                  30          


Ala Ile Ser Ala Leu Ile Asp Glu Ala Gly Ala Arg Ser Ala Arg Ala 
        35                  40                  45              


Gln Gly Leu Pro Ala Pro Ile Thr Ser Thr Asp Arg Leu Leu Glu Asp 
    50                  55                  60                  


Gln Arg Leu Tyr Leu Ala Cys Ser Asp Ala Thr Arg Pro Arg Gly Gly 
65                  70                  75                  80  


Pro Ser Val Leu Val Gly Ile Leu Lys Val Gly Pro Lys Arg Leu Phe 
                85                  90                  95      


Val Ala Lys Pro Ser Gly Gly Met Glu Glu Met Glu Pro Cys Cys Val 
            100                 105                 110         


Leu Asp Phe Tyr Val His Glu Ser Ser Gln Arg Gly Gly Trp Gly Ser 
        115                 120                 125             


Leu Leu Phe Asp Ala Phe Leu Gln Arg Glu Asp Arg His Pro Ala Arg 
    130                 135                 140                 


Leu Ala Tyr Asp Arg Pro Ser Pro Lys Leu Val Ala Phe Met Ala Lys 
145                 150                 155                 160 


His His Asn Leu Arg Ala Phe Ala Lys Gln Asn Asn Asn Phe Val Val 
                165                 170                 175     


Phe Asp Glu Tyr Trp Ser Glu Glu 
            180                 


<210>  50
<211>  564
<212>  PRT
<213>  Physcomitrella patens

<400>  50

Met Val Glu Phe Val Cys Ser Ile Pro Ser Leu Lys Thr Phe Thr Glu 
1               5                   10                  15      


Val Pro Lys Ile Thr Ala Trp Asn Ser Tyr Gln Leu Met Asn Leu Met 
            20                  25                  30          


Arg Gly Lys Asp Gly Glu Glu Met Gln Ile Ile Ile Asn Tyr Met Gly 
        35                  40                  45              


Glu Leu Ser Ala Ile Ala Gln Gly Leu Arg Gly Pro Ile Thr Ser Val 
    50                  55                  60                  


Asp Arg Leu Leu Gln Ser Phe Gln Lys Ile Tyr Leu Leu Thr Ser Ser 
65                  70                  75                  80  


Val Pro Gly Asn Ser Gly His Ile Leu Ala Gln Gly Ile Leu Lys Val 
                85                  90                  95      


Gly Gln Lys His Leu Phe Ile Arg Arg Thr Pro Asn Ala Pro Leu Val 
            100                 105                 110         


Glu Ile Ser Pro Leu Cys Val Leu Asp Phe Tyr Ala Gly Thr Gly Ala 
        115                 120                 125             


Tyr Val Ile Gln Val His Ala Arg Ala Gly Glu Glu Glu Ala Met Ser 
    130                 135                 140                 


Ala Trp Val Arg Leu Ser Ser Phe Pro Ser Pro Val Pro Val Pro Val 
145                 150                 155                 160 


Glu Ile Thr Ser Asn Tyr Asp Lys Pro Ser Asn Lys Leu Leu Ser Phe 
                165                 170                 175     


Met Ser Lys Tyr Tyr Asn Leu Arg Ser Tyr Asn Asp Gln Ala Asn Gln 
            180                 185                 190         


Phe Val Val Tyr Asn Asp Tyr Phe Val Asp Ala Lys Asn Glu Ala Gln 
        195                 200                 205             


Lys Glu Lys Glu Asn Arg Asp Lys Glu Leu Asn Gly Thr Pro Asp Ile 
    210                 215                 220                 


Gly Thr Asn Pro Arg Lys Asp Glu Val Leu His Asp Ser Gln Ala Asn 
225                 230                 235                 240 


Leu Gln Val Ile Asp Val Asp Asp Gln Cys Ser Ser Asn Arg Ser Asp 
                245                 250                 255     


Ile Ser Arg Leu Thr Thr Ala Glu Ala Arg Pro Pro Asn Leu His Val 
            260                 265                 270         


Lys Glu Pro Pro Lys Gln Pro Leu Phe Arg Gly Gly Arg Lys Lys Ile 
        275                 280                 285             


Trp Gln Ser Lys Gln Gly Tyr Ser Glu Lys Pro Pro Asn Ser Ala Asp 
    290                 295                 300                 


Thr Leu His Thr Thr Asp Ala Arg Ser Ser Leu Gln Ser Pro Thr Lys 
305                 310                 315                 320 


Ala Thr Leu Ser Leu Lys Asp Ala Tyr Arg Gln Gly Leu Asn Asp Gln 
                325                 330                 335     


Gly Ile Ser Leu His Ala Arg Lys Ser Ser Asn Ser Leu Ser Ser Glu 
            340                 345                 350         


Pro Lys Arg Cys Gln Glu Asn His Gly Ala Asn Asn Leu His Glu Pro 
        355                 360                 365             


Gly Val Thr Leu Leu Tyr Ser Val Ile Gly Glu Glu Glu Arg Leu Lys 
    370                 375                 380                 


Ile Gln Ser Met Cys Thr Pro Ser Leu Ala Gln Lys Met Asn Val Lys 
385                 390                 395                 400 


His Pro Thr Arg Ala Asn His Lys Asp Pro Lys Pro Ile Lys Pro Arg 
                405                 410                 415     


Pro Asn Met Gly Ser Pro Val Thr Arg Pro Thr Arg Gln Leu Thr Gln 
            420                 425                 430         


Lys Asp Pro Pro Pro Ser Cys Pro Leu Trp Ala Asp Ala Lys Glu Leu 
        435                 440                 445             


Ser Glu Ser Gln His Trp Gln Glu Arg Asn Pro Val Asp Tyr Lys Arg 
    450                 455                 460                 


Thr Gly Lys Thr Met Pro Val Arg Asn Thr Arg Ala Glu Lys Ile Arg 
465                 470                 475                 480 


Ser Ser Ile Asn Arg Met Gly Asp Ala Arg Asn Leu Ala Lys Ala Leu 
                485                 490                 495     


Val His Leu Ser Glu Gln Ser Gly Trp Phe His Cys Gln Trp Ile Asn 
            500                 505                 510         


Asp Ile Cys Asp Thr Trp Cys Val Pro His Tyr Leu Ile Lys Met His 
        515                 520                 525             


Ser Thr Val Asn Trp Ser Ser Gln Ser Trp Lys Asn Arg His Ala Tyr 
    530                 535                 540                 


Thr Glu Leu Ala Val Thr Gly Leu Leu Ala Asn Gly His Tyr Ser Gln 
545                 550                 555                 560 


Met Gly Ser Ala 
                


<210>  51
<211>  249
<212>  PRT
<213>  Paramecium tetraurelia

<400>  51

Met Gln Phe Gln Phe Pro Leu Gln Lys Ala Leu Gln Thr Ser Gln Asn 
1               5                   10                  15      


Gly Ile Ser Val Ile Ser Ala Ser Asn Ser Arg Arg Asn Cys Tyr Leu 
            20                  25                  30          


Asp Glu Val Ile Asp Arg Met Gly Glu Ala Ser Ala Ile Ala Gln Gln 
        35                  40                  45              


Leu Lys Gln Ile Ile Thr Thr Ala Ser Lys Phe Tyr Gly Ser Asp Gln 
    50                  55                  60                  


Arg Ile Tyr Leu Lys Ala Asp Gly Lys Asn Cys Leu Gly Leu Leu Lys 
65                  70                  75                  80  


Val Gly Lys Lys Asn Leu Phe Tyr Arg Asp Tyr Ser Gly Ser Ile Lys 
                85                  90                  95      


Glu Met Gln Pro Leu Cys Val Leu Asp Phe Tyr Val His Glu Ser Val 
            100                 105                 110         


Gln Arg Met Gly Val Gly Lys Glu Leu Phe Glu Glu Met Leu Lys Ser 
        115                 120                 125             


Glu Gln Ile Lys Pro Glu Lys Leu Ala Tyr Asp Arg Pro Ser Gln Lys 
    130                 135                 140                 


Leu Ile Gly Phe Leu Asn Lys His Tyr Asn Leu Asn Gln Tyr Val Pro 
145                 150                 155                 160 


Gln Asn Asn Asn Phe Val Ile Phe Asn Gln Tyr Phe Gly Gln Gly Thr 
                165                 170                 175     


Gln Pro Ile Ala Gln Gly Arg Ser Gln Lys Tyr Ser Arg Asn Ser Gln 
            180                 185                 190         


Ile Asp Gln Leu Asp Ile Met Val Gln Gln Ile Ser Gln Asn Lys Thr 
        195                 200                 205             


Asn Gln Gln Gln Leu Pro Gln Gln Lys Leu Gly Tyr Gln Met Ser Thr 
    210                 215                 220                 


Pro Trp Ala Ile Asp Asn His Thr Asn Ile Tyr Asn Asn Ile Asn Ser 
225                 230                 235                 240 


Gln Arg Thr Asn Val Tyr Lys Ile Asn 
                245                 


<210>  52
<211>  267
<212>  PRT
<213>  Schistosoma japonicum

<400>  52

Met Asp Phe Arg Ala Gly Leu Glu Asn Val Leu Gln Gln Glu Val Thr 
1               5                   10                  15      


Val Ile His Gly Glu Glu Thr Arg Lys Leu Cys Ile Ala Asn Asn Lys 
            20                  25                  30          


Tyr Leu Asn Gly Lys Asp Ala Asp Thr Phe Arg Asn Leu Ala Val Leu 
        35                  40                  45              


Leu Asp His Leu Gly Glu Arg Ser Ala Lys Ala Gln Lys Leu Pro Lys 
    50                  55                  60                  


Pro Val Thr Ser Phe Ile Lys Phe Arg Asn Ser Asp Gln Ser Ile Phe 
65                  70                  75                  80  


Leu Leu Ser Asp Ile Pro Val Lys Lys Phe Val Ile Leu Ile Tyr Met 
                85                  90                  95      


Phe Phe Arg Val Leu Gly Phe Leu Lys Val Gly Arg Lys Arg Leu Phe 
            100                 105                 110         


Val His Asp Ser Lys Gly Val Cys Val Glu Cys Ile Pro Leu Cys Ile 
        115                 120                 125             


Leu Asp Phe Tyr Ile His Glu Ser His Gln Arg Lys Gly Tyr Gly Lys 
    130                 135                 140                 


Lys Leu Phe Asp Phe Met Leu Lys Thr Glu Asn Ile Gln Pro Ser Tyr 
145                 150                 155                 160 


Leu Ala Ile Asp Leu Pro Ser Met Lys Met Ile Gln Phe Leu His Lys 
                165                 170                 175     


His Tyr His Leu Ile Asn Pro Ile Tyr Ser Pro Asn Asn Phe Val Val 
            180                 185                 190         


Tyr Ser Glu Phe Phe Asn Asn Leu Asn Asn Ser Asn Tyr Ser Ile Val 
        195                 200                 205             


Gln Ser Lys Leu Thr Thr Thr Asn Cys Phe Leu Lys Ser Asn Ser Ser 
    210                 215                 220                 


Arg Ile His Gln Asn Lys His Asn His Ser Ile Val Ser Asn Asn Asn 
225                 230                 235                 240 


Asn Asn Asn Asn Asn Asn Ile Ile Ile Ile Ile Ile Ile Gln Asn Ile 
                245                 250                 255     


Thr His His Asn Asn Gln Leu Thr Ile Glu Gln 
            260                 265         


<210>  53
<211>  334
<212>  PRT
<213>  Trypanosoma brucei

<400>  53

Met Thr His Asn Val Met Cys Asp Asp Val Leu Pro Gln Leu Asn Leu 
1               5                   10                  15      


Pro Asp Gly Val Thr Arg Trp Asn Ala Asn Leu Leu Glu Glu Glu Arg 
            20                  25                  30          


Arg Leu Arg Asn Ser Asp Gly His Ala Asp Arg Ile Ile Leu Thr Ile 
        35                  40                  45              


Asn Thr Leu Gly Lys Arg Ser Lys Glu Ala Gln Ser Leu Asn Thr Ile 
    50                  55                  60                  


Leu Thr Ser Val Pro Arg Leu Arg Glu Asn Arg Asp Ala Arg Leu Tyr 
65                  70                  75                  80  


Leu Leu Cys His Gly Gly Arg Gly Val Gly Ile Leu Lys Ile Gly Val 
                85                  90                  95      


Lys Arg Leu Phe Val Val Pro Pro Ser His Ala Gly Leu Met Glu Ile 
            100                 105                 110         


Glu Pro Val Cys Val Leu Asp Phe Phe Val Asp Thr Ser Asn Gln Arg 
        115                 120                 125             


Gln Gly Tyr Gly Lys Ile Leu Phe Glu His Met Leu Ala Phe Glu Arg 
    130                 135                 140                 


Leu Ser Pro Gly Asp Val Ala Ile Asp Arg Pro Ser Val Lys Phe Leu 
145                 150                 155                 160 


Ala Phe Leu Arg Lys His Tyr Gly Leu Val Glu Tyr Thr Pro Gln Ser 
                165                 170                 175     


Asn Asn Phe Val Val Phe His Lys Tyr Phe Glu Arg His Gln Gln Gln 
            180                 185                 190         


Arg Arg Gly Val Gly Gly Ser Gly Arg Ser Gly Tyr Gln His Cys Asn 
        195                 200                 205             


Glu Thr Thr Thr Gln Gln Leu Gly Thr Gln Ser Gly Leu Leu Glu Asp 
    210                 215                 220                 


Ile Asn Gln Thr His Pro Ala Pro Ser Tyr Ala Leu Arg Gly Val Val 
225                 230                 235                 240 


Met Gly His Thr Gly Pro Pro Leu Asp Leu Thr Asn Val Thr Gln Gln 
                245                 250                 255     


Gln Lys Pro Tyr His Gln Pro Phe Ala Thr Gly Arg Lys Thr Ser Tyr 
            260                 265                 270         


Glu Leu Gln Tyr Glu Arg Tyr Leu Gln Ser Gln Asn Cys Arg Pro Thr 
        275                 280                 285             


Gly Asn Ala Gly Tyr Gly Gly Gly Asn Gly Pro Ala Ser Ser Ala Glu 
    290                 295                 300                 


Val Arg Ala Thr Asn Cys Gln Ala Arg Arg Arg Thr Ser Pro Thr Arg 
305                 310                 315                 320 


Ser Gly Val Pro Tyr Asn Ile Ile Asn Gly Ser Thr Gly Ser 
                325                 330                 


<210>  54
<211>  328
<212>  PRT
<213>  Trypanosoma cruzi

<400>  54

Met Ser Ser Thr Ser Gln Val Ala Leu Leu Pro Lys Leu Ser Leu Pro 
1               5                   10                  15      


Asp Gly Val Thr Val Trp Asp Gly Thr Ala Leu Glu Tyr Glu Arg Arg 
            20                  25                  30          


Cys Asn Asn Ile Asp Glu His Ala Val His Leu Met Gln Thr Ile Asn 
        35                  40                  45              


Ile Leu Gly Ile Arg Ser Lys Glu Ala Gln Cys Leu Asn Thr Val Leu 
    50                  55                  60                  


Thr Ser Val Ala Arg Leu Arg Glu Asn Arg Gln Ala Arg Val Tyr Leu 
65                  70                  75                  80  


Leu Cys Gln Asp Gly Tyr Gly Val Gly Ile Leu Lys Met Gly Val Lys 
                85                  90                  95      


Lys Leu Phe Val Thr His Pro Ser Tyr Ser Ser Leu Val Glu Ile Asp 
            100                 105                 110         


Pro Leu Cys Val Leu Asp Phe Phe Val Asp Thr Ser Phe Gln Arg Lys 
        115                 120                 125             


Gly Phe Gly Lys Thr Leu Phe Asp Ala Met Leu Leu Asn Glu Gly Leu 
    130                 135                 140                 


Asn Pro Gly Glu Val Ala Ile Asp Arg Pro Ser Val Lys Phe Leu Ala 
145                 150                 155                 160 


Phe Leu Arg Lys Tyr Tyr Gly Leu Val Glu Tyr Thr Pro Gln Ser Asn 
                165                 170                 175     


Asn Phe Val Val Phe His Arg Tyr Phe Asp Lys Trp Gln Pro Gln Arg 
            180                 185                 190         


Gly Lys Gly His Arg Gly Gly Asn Ala Val Pro Thr Arg Ser Ile Val 
        195                 200                 205             


Arg Pro Gln Asn Cys Leu Arg Val Tyr Pro Glu Tyr Gln Ser Thr Thr 
    210                 215                 220                 


Gly Pro Asn Asp Asn Phe Glu Glu Asp Ala Thr His Arg Thr Pro Pro 
225                 230                 235                 240 


Pro Pro Leu Pro Pro Pro Leu Val Pro Gln Gly Ser Val Asn Ser Pro 
                245                 250                 255     


Gly Pro Gly Lys Lys Thr Ala Tyr Glu Leu Gln Tyr Glu Glu Tyr Leu 
            260                 265                 270         


Arg Glu Gln Ala Tyr Arg Arg Arg Gln Gly Gly Asp Pro Arg Leu Gln 
        275                 280                 285             


Pro Val Pro Asn Pro Val Ser Ser Ser Glu Ile Ala Ala Ala Ser Cys 
    290                 295                 300                 


Gly Ala Arg Arg Arg Met Ser Pro Thr Arg Ser Gly Val Gln Tyr Asn 
305                 310                 315                 320 


Ile Ile Ser Gly Thr Pro Glu His 
                325             


<210>  55
<211>  359
<212>  PRT
<213>  Tribolium castaneum

<400>  55

Met Glu Phe Lys Phe Ala Val Asn Asp Val Phe Lys Gln Pro Ile Val 
1               5                   10                  15      


Lys Ile Gly Asn Asn Leu Leu Pro Pro Gly Phe Thr Gly Asp Arg Arg 
            20                  25                  30          


Ala Phe Trp Asp Val Val Gly Lys Val Ser Glu Val Val Asn Ala Met 
        35                  40                  45              


Gly Glu Ala Ser Ala Ala Ala Gln Gly Leu Thr Lys Pro Ile Thr Thr 
    50                  55                  60                  


Ala Glu Arg Leu Arg Asn Ser Glu His Ser Val Tyr Leu Leu Ile Asp 
65                  70                  75                  80  


Gln Asn Ala Gly Asn Gly Arg Gly Ala Val Thr Gly Met Leu Lys Thr 
                85                  90                  95      


Gly Met Lys Gly Leu Tyr Val Phe Asp Arg Asn Gly Gln His Tyr Gln 
            100                 105                 110         


Val Ser Pro Pro Cys Val Leu Asp Phe Tyr Val His Glu Ser Arg Gln 
        115                 120                 125             


Arg Thr Gly Leu Gly Lys Arg Leu Phe Glu His Met Leu Gln Thr Glu 
    130                 135                 140                 


Ser Ile Glu Pro Val Lys Met Ala Ile Asp Arg Pro Ser Glu Lys Phe 
145                 150                 155                 160 


Leu Gly Phe Leu Asn Lys His Tyr Ser Leu Asn Asn Pro Val Lys Gln 
                165                 170                 175     


Met Asn Asn Tyr Val Val Phe Asp Gly Phe Phe Pro Gly Ala Gln Asp 
            180                 185                 190         


Lys Asn Gly Thr Val Glu Ser His Ser Ser His Ser Asn Thr Pro Val 
        195                 200                 205             


Gly Lys Lys Gln Ser Ala Asn Gly Leu Gln Thr Ser Thr Tyr Ala Ser 
    210                 215                 220                 


Pro Leu Gly Arg Tyr Gly Ala Pro Arg Pro Pro Cys Ser Met Gly Gln 
225                 230                 235                 240 


Ile Ile His Asn Gln Thr Ser Thr Ile Ala Lys Thr Pro Glu Pro Thr 
                245                 250                 255     


Gly Glu Thr Gln Val Met Asp Glu Lys Val Asn Ser Ser Pro Lys Leu 
            260                 265                 270         


Glu Arg Pro Arg Ser Leu Ser Ile Gln Pro Ser Asp Glu Pro Thr Glu 
        275                 280                 285             


Asp Asn Asn Gln Asn Glu Asn Asp Val Glu Ser Glu Val Leu Glu Glu 
    290                 295                 300                 


Val Glu Ile Ile Glu Asn Leu Thr Ile Glu Asn Gly Ala Asp Val Val 
305                 310                 315                 320 


Asp Thr Lys Asn Glu Lys Ile Ala Thr Pro Glu Ala Lys Thr Pro Gly 
                325                 330                 335     


Lys Arg Thr Pro Ser His Leu Thr Glu Gln Gly Phe Phe Asp Leu Lys 
            340                 345                 350         


Phe Tyr His Asn Lys Leu Trp 
        355                 


<210>  56
<211>  488
<212>  PRT
<213>  Tetrahymena thermophila

<400>  56

Met Phe Lys Asn Gln Leu Leu Ser Leu Ser Leu Arg Ile Gln Lys Leu 
1               5                   10                  15      


Arg Leu Cys Arg Gln Gly Asn Gln Leu Lys Val Leu Gln Lys Ser Ile 
            20                  25                  30          


Asn Gln Leu Leu Phe Lys Thr Gln Ser Ile Asp Gln Ile Leu Gln Tyr 
        35                  40                  45              


Leu Gln Gln Lys Lys Lys Thr His Gln Ser Ile Leu Glu Asn Gln Asn 
    50                  55                  60                  


Gln His Ile His Ser Ile Gly Leu Val Ser Gln Leu Thr Asn Gln Lys 
65                  70                  75                  80  


Ile Asn Lys Gln Lys Asn Gln Lys Ala Met Glu Phe Asn Phe Ile Ile 
                85                  90                  95      


Asn Lys Leu Val Gln Leu Asp Gln Gln Gly Leu Gly Val Tyr Ile Pro 
            100                 105                 110         


Arg Ala Ser Arg Ser Lys Val Ser Ser Gln Gln Glu Gln Gln Leu Gly 
        115                 120                 125             


Gln Val Leu Asn Thr Met Gly Glu Arg Ser Ala Ile Ala Gln Gly Leu 
    130                 135                 140                 


Lys Gln Val Ile Thr Asn Tyr Asp Lys Val Gln Gly Thr Asp Gln Arg 
145                 150                 155                 160 


Val Tyr Ile Val Ala Glu Gly Arg Thr Cys Gln Gly Phe Leu Lys Val 
                165                 170                 175     


Gly Gln Lys Asn Leu Phe Tyr Arg Asp Met Met Gly Asn Ile Lys Glu 
            180                 185                 190         


Ile Lys Pro Leu Cys Val Leu Asp Phe Tyr Val His Glu Ser Cys Gln 
        195                 200                 205             


Arg Gln Gly Tyr Gly Lys Leu Leu Phe Glu Tyr Met Ile Gln Cys Glu 
    210                 215                 220                 


Gln Thr Ser Pro Glu Lys Leu Ala Tyr Asp Arg Pro Ser Pro Lys Leu 
225                 230                 235                 240 


Ile Ala Phe Leu Lys Lys His Tyr Asn Leu Val Lys Tyr Ile Ala Gln 
                245                 250                 255     


Asn Asn Asn Phe Val Val Phe Asp Gln Tyr Phe Arg Ser Asp Ala Ser 
            260                 265                 270         


Ser Gln Asn Lys Gln Asn Gln Asn Thr Arg Ser Tyr Ser Gln Pro Tyr 
        275                 280                 285             


Ser Asp Tyr Ser Ser Gln Ile Pro Thr Asn Tyr Pro Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gln Ser Asn Ser Lys Ser Tyr Pro Tyr Lys Gln Glu Asn Asn Ile 
305                 310                 315                 320 


Asp Leu Met Gln His Ser Ser Ser Arg Asn Asn Lys Glu Phe Leu Asn 
                325                 330                 335     


Ala Gly Arg Ala Ile Leu Ser Lys Glu Glu Ile Tyr Lys Lys Asp Asn 
            340                 345                 350         


Leu Ser Gln Gln Asn Ile Glu Asn Thr Leu Asn Asn Ile Asn Asn Ser 
        355                 360                 365             


Gln Tyr Ser Thr Lys Ser Gln Gln Gln Gln Gln Tyr Gln Lys Asp Tyr 
    370                 375                 380                 


Gln Leu Asp Lys Tyr Glu Asn Asn Trp Gly Ala Asp Lys Asn Ile Lys 
385                 390                 395                 400 


Lys Pro Pro Phe Pro Gly Gln Asp Arg Gln Leu Asp Lys Ile Gln Gln 
                405                 410                 415     


Lys Ile Gln Gln Thr Glu Arg Glu Leu Asp Val Val Asn Gln Gln Ile 
            420                 425                 430         


Ile Lys Gln Arg Gln Asn Leu Ser Gln Asp Pro Leu Thr Gln Asn His 
        435                 440                 445             


Arg Ala Gln Asn Val Tyr Asn Thr Asn Gln Phe Gly Thr Ser Pro Trp 
    450                 455                 460                 


Ala Gln Thr Gly Phe Asn Tyr Tyr Ser Thr Ser Ser Ser Asn Tyr Gly 
465                 470                 475                 480 


Asn His Tyr Thr Tyr Tyr Lys Lys 
                485             


<210>  57
<211>  418
<212>  PRT
<213>  Xenopus laevis

<400>  57

Met Glu Phe Glu Phe Asp Val His Lys Ile Phe Leu Glu Pro Ile Thr 
1               5                   10                  15      


Lys Leu Asp Asn Asn Leu Ile Pro Pro Arg Arg Pro Leu Ile Ser Ser 
            20                  25                  30          


Ser Glu Ala Gln Lys Gln Ile Met Thr Val Ile Asp Glu Ile Gly Lys 
        35                  40                  45              


Ala Ser Ala Lys Ala Gln Arg Leu Pro Ala Ser Ile Thr Ser Ala Ser 
    50                  55                  60                  


Arg Met Gln Ala Asn Lys His His Leu Tyr Ile Leu Lys Asp Cys Thr 
65                  70                  75                  80  


Pro Lys Thr Ala Gly Arg Gly Ala Val Ile Gly Phe Leu Lys Val Gly 
                85                  90                  95      


Tyr Lys Lys Leu Phe Ile Leu Asp Gln Lys Gly Ser His Ile Glu Ala 
            100                 105                 110         


Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu Ser Leu Gln Arg 
        115                 120                 125             


His Gly Phe Gly Lys Glu Leu Phe Ser Phe Met Leu Arg Asn Glu Gln 
    130                 135                 140                 


Val Asp Val Gln His Leu Ala Ile Asp Arg Pro Ser Glu Lys Phe Leu 
145                 150                 155                 160 


Ser Phe Leu Arg Lys His Phe Asn Leu Trp Ser Thr Ile Pro Gln Val 
                165                 170                 175     


Asn Asn Phe Val Val Phe Glu Gly Phe Phe Arg Asp Arg Lys Ala Ser 
            180                 185                 190         


Val Lys Lys Thr Pro Ala Lys Arg Thr Glu Gly Glu Ile Lys Pro Tyr 
        195                 200                 205             


Ser Leu Thr Asp Arg Asp Phe Leu Lys Gln Glu Glu Gly Leu Pro Trp 
    210                 215                 220                 


Pro Leu Ser Gln Ala Gln Ile Asn Leu Asn Arg Ala Ser Ser Leu Gly 
225                 230                 235                 240 


Ser Ser Pro Thr Arg Ala Cys Ser Arg Pro Pro Pro Gly Glu Glu Asp 
                245                 250                 255     


Phe Val Lys Ser Leu Arg Asn Cys Arg Pro His Ser Leu Gln Arg Ala 
            260                 265                 270         


Ala Ser Ser Glu Gln Glu Asp His Ser Gln Arg Arg Arg Thr Ser Glu 
        275                 280                 285             


Met Asn Leu Ser Arg Gly Leu Leu Ala Gln Lys Asn Gly Tyr Ser Arg 
    290                 295                 300                 


Tyr Leu Ser Pro Pro Pro Pro Leu Leu Thr Gln Gly Pro Tyr Ala Ala 
305                 310                 315                 320 


Ala Gln Ile Lys Glu Gln Gln Ser Arg Thr Asp Ser Ser Ala Gln Glu 
                325                 330                 335     


Gly Arg Thr Gln Asp Arg Pro Asn Gly Ser Asn Ser Gln His Gln Asn 
            340                 345                 350         


Asp Leu Ile Ser Ser Lys Gln His Val Gln Asp Leu His Met Glu Leu 
        355                 360                 365             


Ala Ala Gly Arg Thr Met Ser Asp Leu Lys Glu Gly Gln Asn Ala Thr 
    370                 375                 380                 


Lys Ser Pro Trp Cys Asp His Pro Ser Tyr Thr Val Leu Gly Thr Val 
385                 390                 395                 400 


Leu Asn Ala Ala Trp Val Lys Lys Lys Gln Glu Leu Arg Ser Thr Arg 
                405                 410                 415     


Pro Trp 
        


<210>  58
<211>  297
<212>  PRT
<213>  Xenopus (Silurana) tropicalis

<400>  58

Met Glu Phe Asp Phe Asp Val His Lys Ile Phe Leu Glu Pro Ile Thr 
1               5                   10                  15      


Lys Leu Asp Ser Ser Leu Ile Pro Ser Arg Arg Pro Leu Ile Ala Ser 
            20                  25                  30          


Ser Glu Ala Gln Lys Gln Ile Met Thr Val Ile Asp Glu Ile Gly Lys 
        35                  40                  45              


Ala Ser Ala Lys Ala Gln Arg Leu Pro Ala Pro Ile Thr Ser Ala Ser 
    50                  55                  60                  


Arg Met Gln Thr Asn Lys His His Leu Tyr Ile Leu Lys Asp Cys Thr 
65                  70                  75                  80  


Pro Lys Thr Ala Gly Arg Gly Ala Val Ile Gly Phe Leu Lys Val Gly 
                85                  90                  95      


Cys Lys Lys Leu Phe Val Leu Asp Gln Lys Gly Ser His Ile Glu Ala 
            100                 105                 110         


Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu Thr Leu Gln Arg 
        115                 120                 125             


His Gly Phe Gly Lys Glu Leu Phe Thr Phe Met Leu Lys Asn Glu Gln 
    130                 135                 140                 


Val Asp Val His His Leu Ala Ile Asp Arg Pro Ser Glu Lys Phe Leu 
145                 150                 155                 160 


Ser Phe Leu Arg Lys His Phe Asn Leu Trp Ser Thr Ile Pro Gln Val 
                165                 170                 175     


Asn Asn Phe Val Val Phe Asp Gly Phe Phe Arg Asp Trp Lys Ala Ser 
            180                 185                 190         


Val Lys Lys Thr Pro Ala Lys Arg Thr Glu Gly Glu Ile Lys Pro Tyr 
        195                 200                 205             


Ser Leu Thr Asp Arg Asp Phe Leu Lys Gln Glu Glu Gly Leu Pro Trp 
    210                 215                 220                 


Pro Phe Ser Gln Ser Gln Leu Asn Leu Asn Arg Ala Ser Ser Leu Gly 
225                 230                 235                 240 


Ser Ser Pro Thr Arg Ala Cys Ser Arg His Ser Pro Gly Glu Glu Asp 
                245                 250                 255     


Phe Val Lys Ser Leu Arg Asn Cys Arg Pro His Ser Leu His Arg Thr 
            260                 265                 270         


Ala Asn Ser Glu Gln Glu Asp His Ser Gln Arg Arg Arg Thr Ser Ser 
        275                 280                 285             


Leu Asn Arg Pro Gln Ser Ile His His 
    290                 295         


<210>  59
<211>  639
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  59

Met Glu Phe Asp Phe Ala Ser Leu Ala Phe Gly Gly Glu Gln His Ile 
1               5                   10                  15      


Ser Phe Trp Asp Ser Lys Arg Ile Ala Thr Leu Lys Pro Asp Asp Gln 
            20                  25                  30          


Glu Leu Leu Thr Lys Leu Leu Asp Val Phe Gly Lys Lys Ser Ala Val 
        35                  40                  45              


Ala Gln Gly Leu Gly Ala Pro Val Thr Asp Ile Tyr Arg Leu Arg Ser 
    50                  55                  60                  


Thr Asp Gln Arg Leu Tyr Leu Tyr Met Tyr Arg Glu Ser Arg Lys Thr 
65                  70                  75                  80  


Val Val Leu Gly Gly Leu Lys Val Gly Ser Lys Arg Leu Phe Val Arg 
                85                  90                  95      


Thr Gly Thr Ala Asp Leu Arg Glu Ile Glu Pro Val Cys Val Leu Asp 
            100                 105                 110         


Phe Tyr Val His Glu Ser Cys Gln Arg Gln Gly Val Gly Lys Ala Leu 
        115                 120                 125             


Phe Glu His Phe Leu Met Ala Glu Gly His Asp Pro Ala Thr Leu Ala 
    130                 135                 140                 


Tyr Asp Arg Pro Ser Pro Lys Leu Leu Ala Phe Leu Arg Lys His Tyr 
145                 150                 155                 160 


Gly Leu Glu Gln Tyr Val Pro Gln Ser Asn Asn Tyr Val Val Phe Asp 
                165                 170                 175     


Arg Tyr Trp Glu Leu Cys Pro Pro Gly Ser Arg Gln Pro His Arg Gly 
            180                 185                 190         


Pro Gly Ser Met Pro Pro Gly Ala Ser Gly Gln Leu Gln Gly Arg Asn 
        195                 200                 205             


Ala Ser Arg Gly Ser Val Ala Ser Ile Ser Thr Pro Ser Gly His Gly 
    210                 215                 220                 


Gly His Gly Pro Arg Ala Thr Pro Leu Met Gly Met Met Pro Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Gly Gly Tyr Pro Pro His Trp Thr Pro Ser Ala Leu Gly 
                245                 250                 255     


Ser Pro Ser Gly Gly His Pro Gly Gly Pro Pro Ala Pro Ile Gly Asn 
            260                 265                 270         


Ser Pro Ser Phe Gly Arg Arg Trp Ala Ser Asn Asn Phe Gly Gln Gly 
        275                 280                 285             


Pro Pro Gln Ala Ala Pro Pro Tyr Pro Ala Pro Gly Thr Ala Gly Gly 
    290                 295                 300                 


Pro Ala Phe Ser Ile Pro Pro Ala Gly Gly Asp Ala Gln Gly Gly Ile 
305                 310                 315                 320 


Val Asp Ala Leu Asp Ala Phe Ala Arg Gln Gln Gln Gln Gln Gly Ser 
                325                 330                 335     


Gly Ala Ser Ser Pro Gln Arg Gly Gly Ala Gly Ala Pro Trp Glu Gly 
            340                 345                 350         


Gly Ala Ala Gly Pro Ala Gly Thr Gly Ala Ser Gly Phe Gly Gly Gly 
        355                 360                 365             


Ala Gly Thr Trp Pro Pro Gln Gly Ala Pro Glu Leu Pro Pro Ala Gly 
    370                 375                 380                 


Ala Pro Ser Gly Met Gln Pro Pro Gly Ser Arg Gly Ala Tyr Ser Tyr 
385                 390                 395                 400 


Arg Pro Pro Trp Ala Thr Asp Glu Ala Ala Gly Pro Ser Gly Gly Ser 
                405                 410                 415     


Ala Ser Gly Gly Val Asp Ala Gly Pro Gly Ala Gly Pro Gly Ala Ala 
            420                 425                 430         


Gly Tyr Ala Gly Phe Asn Ser Pro Pro Pro Pro Met Arg Thr Pro Ser 
        435                 440                 445             


Lys Asp Arg Phe Gly Met Gly Pro Gly Asn Gly Gly Pro Ala Pro Val 
    450                 455                 460                 


Gln Arg Ser Pro Met His Ser Ile Leu Gly Gly Gly Gly Gly Tyr Asp 
465                 470                 475                 480 


Ala Val Ala Gly Gly Arg Ser Gly Ala Ala Gln Thr Arg Ala Leu Gln 
                485                 490                 495     


Gln Gln Leu Leu Ser Met Gln Ala Gly Asp Gly Ala Val Ala Ala Ala 
            500                 505                 510         


Ala Ala Gly Gly Pro Val Leu Gly Gly Gly Tyr Gly Gly Gly Gly Gly 
        515                 520                 525             


His Pro Gly Ser Tyr Gln Gln Gln Gln Gln His Ala Pro Pro Ser Leu 
    530                 535                 540                 


Tyr Ser Gly Ala Pro Pro Ala His Gly Ala Gly Gln Gly Gly Asp Glu 
545                 550                 555                 560 


Asp Gly Gly Arg Leu Pro Gly Met Met Gly His Gly Ser Leu Ala Leu 
                565                 570                 575     


Gly Met Leu Gly Ala Ala Pro Ser Gly Arg His Gly Ala Gly Ser Gly 
            580                 585                 590         


Gly His Ala Gly Gly Pro Gly Gly Gly Pro Pro Gly Gly Thr Ser Ala 
        595                 600                 605             


Gly Thr Pro Pro Ala Ala Gly Gly His Ser Ala Ala Lys Leu Met Ala 
    610                 615                 620                 


Val Lys Gln Arg Ser Gly Ala Gly Ala Ala Asp Cys Leu Val Trp 
625                 630                 635                 


