                         SEQUENCE LISTING

<110>  Cornell University
 
<120>  METHOD FOR DIAGNOSING MELANOCYTIC PROLIFERATIONS

<130>  707638 (Cornell 5102-02-PC)

<150>  61/326,174
<151>  2010-04-20

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  1610
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  sACfl

<400>  1

Met Asn Thr Pro Lys Glu Glu Phe Gln Asp Trp Pro Ile Val Arg Ile 
1               5                   10                  15      


Ala Ala His Leu Pro Asp Leu Ile Val Tyr Gly His Phe Ser Pro Glu 
            20                  25                  30          


Arg Pro Phe Met Asp Tyr Phe Asp Gly Val Leu Met Phe Val Asp Ile 
        35                  40                  45              


Ser Gly Phe Thr Ala Met Thr Glu Lys Phe Ser Ser Ala Met Tyr Met 
    50                  55                  60                  


Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu Asn Tyr His Ile Ser 
65                  70                  75                  80  


Ala Ile Val Glu Lys Val Leu Ile Phe Gly Gly Asp Ile Leu Lys Phe 
                85                  90                  95      


Ala Gly Asp Ala Leu Leu Ala Leu Trp Arg Val Glu Arg Lys Gln Leu 
            100                 105                 110         


Lys Asn Ile Ile Thr Val Val Ile Lys Cys Ser Leu Glu Ile His Gly 
        115                 120                 125             


Leu Phe Glu Thr Gln Glu Trp Glu Glu Gly Leu Asp Ile Arg Val Lys 
    130                 135                 140                 


Ile Gly Leu Ala Ala Gly His Ile Ser Met Leu Val Phe Gly Asp Glu 
145                 150                 155                 160 


Thr His Ser His Phe Leu Val Ile Gly Gln Ala Val Asp Asp Val Arg 
                165                 170                 175     


Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile Leu Ser Pro Asn 
            180                 185                 190         


Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile Glu Ser Val Pro 
        195                 200                 205             


Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro Pro Pro Asn Phe 
    210                 215                 220                 


Asn Phe Asp Glu Phe Phe Thr Lys Cys Thr Thr Phe Met His Tyr Tyr 
225                 230                 235                 240 


Pro Ser Gly Glu His Lys Asn Leu Leu Arg Leu Ala Cys Thr Leu Lys 
                245                 250                 255     


Pro Asp Pro Glu Leu Glu Met Ser Leu Gln Lys Tyr Val Met Glu Ser 
            260                 265                 270         


Ile Leu Lys Gln Ile Asp Asn Lys Gln Leu Gln Gly Tyr Leu Ser Glu 
        275                 280                 285             


Leu Arg Pro Val Thr Ile Val Phe Val Asn Leu Met Phe Glu Asp Gln 
    290                 295                 300                 


Asp Lys Ala Glu Glu Ile Gly Pro Ala Ile Gln Asp Ala Tyr Met His 
305                 310                 315                 320 


Ile Thr Ser Val Leu Lys Ile Phe Gln Gly Gln Ile Asn Lys Val Phe 
                325                 330                 335     


Met Phe Asp Lys Gly Cys Ser Phe Leu Cys Val Phe Gly Phe Pro Gly 
            340                 345                 350         


Glu Lys Val Pro Asp Glu Leu Thr His Ala Leu Glu Cys Ala Met Asp 
        355                 360                 365             


Ile Phe Asp Phe Cys Ser Gln Val His Lys Ile Gln Thr Val Ser Ile 
    370                 375                 380                 


Gly Val Ala Ser Gly Ile Val Phe Cys Gly Ile Val Gly His Thr Val 
385                 390                 395                 400 


Arg His Glu Tyr Thr Val Ile Gly Gln Lys Val Asn Leu Ala Ala Arg 
                405                 410                 415     


Met Met Met Tyr Tyr Pro Gly Ile Val Thr Cys Asp Ser Val Thr Tyr 
            420                 425                 430         


Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu Leu Pro Lys Lys 
        435                 440                 445             


Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr Gln Tyr Trp Gly 
    450                 455                 460                 


Arg Thr Glu Lys Val Met Phe Gly Met Ala Cys Leu Ile Cys Asn Arg 
465                 470                 475                 480 


Lys Glu Asp Tyr Pro Leu Leu Gly Arg Asn Lys Glu Ile Asn Tyr Phe 
                485                 490                 495     


Met Tyr Thr Met Lys Lys Phe Leu Ile Ser Asn Ser Ser Gln Val Leu 
            500                 505                 510         


Met Tyr Glu Gly Leu Pro Gly Tyr Gly Lys Ser Gln Ile Leu Met Lys 
        515                 520                 525             


Ile Glu Tyr Leu Ala Gln Gly Lys Asn His Arg Ile Ile Ala Ile Ser 
    530                 535                 540                 


Leu Asn Lys Ile Ser Phe His Gln Thr Phe Tyr Thr Ile Gln Met Phe 
545                 550                 555                 560 


Met Ala Asn Val Leu Gly Leu Asp Thr Cys Lys His Tyr Lys Glu Arg 
                565                 570                 575     


Gln Thr Asn Leu Arg Asn Lys Val Met Thr Leu Leu Asp Glu Lys Phe 
            580                 585                 590         


Tyr Cys Leu Leu Asn Asp Ile Phe His Val Gln Phe Pro Ile Ser Arg 
        595                 600                 605             


Glu Ile Ser Arg Met Ser Thr Leu Lys Lys Gln Lys Gln Leu Glu Ile 
    610                 615                 620                 


Leu Phe Met Lys Ile Leu Lys Leu Ile Val Lys Glu Glu Arg Ile Ile 
625                 630                 635                 640 


Phe Ile Ile Asp Glu Ala Gln Phe Val Asp Ser Thr Ser Trp Arg Phe 
                645                 650                 655     


Met Glu Lys Leu Ile Arg Thr Leu Pro Ile Phe Ile Ile Met Ser Leu 
            660                 665                 670         


Cys Pro Phe Val Asn Ile Pro Cys Ala Ala Ala Arg Ala Val Ile Lys 
        675                 680                 685             


Asn Arg Asn Thr Thr Tyr Ile Val Val Gly Ala Val Gln Pro Asn Asp 
    690                 695                 700                 


Ile Ser Asn Lys Ile Cys Leu Asp Leu Asn Val Ser Cys Ile Ser Lys 
705                 710                 715                 720 


Glu Leu Asp Ser Tyr Leu Gly Glu Gly Ser Cys Gly Ile Pro Phe Tyr 
                725                 730                 735     


Cys Glu Glu Leu Leu Lys Asn Leu Glu His His Glu Val Leu Val Phe 
            740                 745                 750         


Gln Gln Thr Glu Ser Glu Glu Lys Thr Asn Arg Thr Trp Asn Asn Leu 
        755                 760                 765             


Phe Lys Tyr Ser Ile Lys Leu Thr Glu Lys Leu Asn Met Val Thr Leu 
    770                 775                 780                 


His Ser Asp Lys Glu Ser Glu Glu Val Cys His Leu Thr Ser Gly Val 
785                 790                 795                 800 


Arg Leu Lys Asn Leu Ser Pro Pro Thr Ser Leu Lys Glu Ile Ser Leu 
                805                 810                 815     


Ile Gln Leu Asp Ser Met Arg Leu Ser His Gln Met Leu Val Arg Cys 
            820                 825                 830         


Ala Ala Ile Ile Gly Leu Thr Phe Thr Thr Glu Leu Leu Phe Glu Ile 
        835                 840                 845             


Leu Pro Cys Trp Asn Met Lys Met Met Ile Lys Thr Leu Ala Thr Leu 
    850                 855                 860                 


Val Glu Ser Asn Ile Phe Tyr Cys Phe Arg Asn Gly Lys Glu Leu Gln 
865                 870                 875                 880 


Lys Ala Leu Lys Gln Asn Asp Pro Ser Phe Glu Val His Tyr Arg Ser 
                885                 890                 895     


Leu Ser Leu Lys Pro Ser Glu Gly Met Asp His Gly Glu Glu Glu Gln 
            900                 905                 910         


Leu Arg Glu Leu Glu Asn Glu Val Ile Glu Cys His Arg Ile Arg Phe 
        915                 920                 925             


Cys Asn Pro Met Met Gln Lys Thr Ala Tyr Glu Leu Trp Leu Lys Asp 
    930                 935                 940                 


Gln Arg Lys Ala Met His Leu Lys Cys Ala Arg Phe Leu Glu Glu Asp 
945                 950                 955                 960 


Ala His Arg Cys Asp His Cys Arg Gly Arg Asp Phe Ile Pro Tyr His 
                965                 970                 975     


His Phe Thr Val Asn Ile Arg Leu Asn Ala Leu Asp Met Asp Ala Ile 
            980                 985                 990         


Lys Lys Met Ala Met Ser His Gly  Phe Lys Thr Glu Glu  Lys Leu Ile 
        995                 1000                 1005             


Leu Ser  Asn Ser Glu Ile Pro  Glu Thr Ser Ala Phe  Phe Pro Glu 
    1010                 1015                 1020             


Asn Arg  Ser Pro Glu Glu Ile  Arg Glu Lys Ile Leu  Asn Phe Phe 
    1025                 1030                 1035             


Asp His  Val Leu Thr Lys Met  Lys Thr Ser Asp Glu  Asp Ile Ile 
    1040                 1045                 1050             


Pro Leu  Glu Ser Cys Gln Cys  Glu Glu Ile Leu Glu  Ile Val Ile 
    1055                 1060                 1065             


Leu Pro  Leu Ala His His Phe  Leu Ala Leu Gly Glu  Asn Asp Lys 
    1070                 1075                 1080             


Ala Leu  Tyr Tyr Phe Leu Glu  Ile Ala Ser Ala Tyr  Leu Ile Phe 
    1085                 1090                 1095             


Cys Asp  Asn Tyr Met Ala Tyr  Met Tyr Leu Asn Glu  Gly Gln Lys 
    1100                 1105                 1110             


Leu Leu  Lys Thr Leu Lys Lys  Asp Lys Ser Trp Ser  Gln Thr Phe 
    1115                 1120                 1125             


Glu Ser  Ala Thr Phe Tyr Ser  Leu Lys Gly Glu Val  Cys Phe Asn 
    1130                 1135                 1140             


Met Gly  Gln Ile Val Leu Ala  Lys Lys Met Leu Arg  Lys Ala Leu 
    1145                 1150                 1155             


Lys Leu  Leu Asn Arg Ile Phe  Pro Tyr Asn Leu Ile  Ser Leu Phe 
    1160                 1165                 1170             


Leu His  Ile His Val Glu Lys  Asn Arg His Phe His  Tyr Val Asn 
    1175                 1180                 1185             


Arg Gln  Ala Gln Glu Ser Pro  Pro Pro Gly Lys Lys  Arg Leu Ala 
    1190                 1195                 1200             


Gln Leu  Tyr Arg Gln Thr Val  Cys Leu Ser Leu Leu  Trp Arg Ile 
    1205                 1210                 1215             


Tyr Ser  Tyr Ser Tyr Leu Phe  His Cys Lys Tyr Tyr  Ala His Leu 
    1220                 1225                 1230             


Ala Val  Met Met Gln Met Asn  Thr Ala Leu Glu Thr  Gln Asn Cys 
    1235                 1240                 1245             


Phe Gln  Ile Ile Lys Ala Tyr  Leu Asp Tyr Ser Leu  Tyr His His 
    1250                 1255                 1260             


Leu Ala  Gly Tyr Lys Gly Val  Trp Phe Lys Tyr Glu  Val Met Ala 
    1265                 1270                 1275             


Met Glu  His Ile Phe Asn Leu  Pro Leu Lys Gly Glu  Gly Ile Glu 
    1280                 1285                 1290             


Ile Val  Ala Tyr Val Ala Glu  Thr Leu Val Phe Asn  Lys Leu Ile 
    1295                 1300                 1305             


Met Gly  His Leu Asp Leu Ala  Ile Glu Leu Gly Ser  Arg Ala Leu 
    1310                 1315                 1320             


Gln Met  Trp Ala Leu Leu Gln  Asn Pro Asn Arg His  Tyr Gln Ser 
    1325                 1330                 1335             


Leu Cys  Arg Leu Ser Arg Cys  Leu Leu Leu Asn Ser  Arg Tyr Pro 
    1340                 1345                 1350             


Gln Leu  Ile Gln Val Leu Gly  Arg Leu Trp Glu Leu  Ser Val Thr 
    1355                 1360                 1365             


Gln Glu  His Ile Phe Ser Lys  Ala Phe Phe Tyr Phe  Val Cys Leu 
    1370                 1375                 1380             


Asp Ile  Leu Leu Tyr Ser Gly  Phe Val Tyr Arg Thr  Phe Glu Glu 
    1385                 1390                 1395             


Cys Leu  Glu Phe Ile His Gln  Tyr Glu Asn Asn Arg  Ile Leu Lys 
    1400                 1405                 1410             


Phe His  Ser Gly Leu Leu Leu  Gly Leu Tyr Ser Ser  Val Ala Ile 
    1415                 1420                 1425             


Trp Tyr  Ala Arg Leu Gln Glu  Trp Asp Asn Phe Tyr  Lys Phe Ser 
    1430                 1435                 1440             


Asn Arg  Ala Lys Asn Leu Leu  Pro Arg Arg Thr Met  Thr Leu Thr 
    1445                 1450                 1455             


Tyr Tyr  Asp Gly Ile Ser Arg  Tyr Met Glu Gly Gln  Val Leu His 
    1460                 1465                 1470             


Leu Gln  Lys Gln Ile Lys Glu  Gln Ser Glu Asn Ala  Gln Ala Ser 
    1475                 1480                 1485             


Gly Glu  Glu Leu Leu Lys Asn  Leu Glu Asn Leu Val  Ala Gln Asn 
    1490                 1495                 1500             


Thr Thr  Gly Pro Val Phe Cys  Pro Arg Leu Tyr His  Leu Met Ala 
    1505                 1510                 1515             


Tyr Val  Cys Ile Leu Met Gly  Asp Gly Gln Lys Cys  Gly Leu Phe 
    1520                 1525                 1530             


Leu Asn  Thr Ala Leu Arg Leu  Ser Glu Thr Gln Gly  Asn Ile Leu 
    1535                 1540                 1545             


Glu Lys  Cys Trp Leu Asn Met  Asn Lys Glu Ser Trp  Tyr Ser Thr 
    1550                 1555                 1560             


Ser Glu  Leu Lys Glu Asp Gln  Trp Leu Gln Thr Ile  Leu Ser Leu 
    1565                 1570                 1575             


Pro Ser  Trp Glu Lys Ile Val  Ala Gly Arg Val Asn  Ile Gln Asp 
    1580                 1585                 1590             


Leu Gln  Lys Asn Lys Phe Leu  Met Arg Ala Asn Thr  Val Asp Asn 
    1595                 1600                 1605             


His Phe  
    1610 


<210>  2
<211>  470
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  sACt

<400>  2

Met Asn Thr Pro Lys Glu Glu Phe Gln Asp Trp Pro Ile Val Arg Ile 
1               5                   10                  15      


Ala Ala His Leu Pro Asp Leu Ile Val Tyr Gly His Phe Ser Pro Glu 
            20                  25                  30          


Arg Pro Phe Met Asp Tyr Phe Asp Gly Val Leu Met Phe Val Asp Ile 
        35                  40                  45              


Ser Gly Phe Thr Ala Met Thr Glu Lys Phe Ser Ser Ala Met Tyr Met 
    50                  55                  60                  


Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu Asn Tyr His Ile Ser 
65                  70                  75                  80  


Ala Ile Val Glu Lys Val Leu Ile Phe Gly Gly Asp Ile Leu Lys Phe 
                85                  90                  95      


Ala Gly Asp Ala Leu Leu Ala Leu Trp Arg Val Glu Arg Lys Gln Leu 
            100                 105                 110         


Lys Asn Ile Ile Thr Val Val Ile Lys Cys Ser Leu Glu Ile His Gly 
        115                 120                 125             


Leu Phe Glu Thr Gln Glu Trp Glu Glu Gly Leu Asp Ile Arg Val Lys 
    130                 135                 140                 


Ile Gly Leu Ala Ala Gly His Ile Ser Met Leu Val Phe Gly Asp Glu 
145                 150                 155                 160 


Thr His Ser His Phe Leu Val Ile Gly Gln Ala Val Asp Asp Val Arg 
                165                 170                 175     


Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile Leu Ser Pro Asn 
            180                 185                 190         


Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile Glu Ser Val Pro 
        195                 200                 205             


Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro Pro Pro Asn Phe 
    210                 215                 220                 


Asn Phe Asp Glu Phe Phe Thr Lys Cys Thr Thr Phe Met His Tyr Tyr 
225                 230                 235                 240 


Pro Ser Gly Glu His Lys Asn Leu Leu Arg Leu Ala Cys Thr Leu Lys 
                245                 250                 255     


Pro Asp Pro Glu Leu Glu Met Ser Leu Gln Lys Tyr Val Met Glu Ser 
            260                 265                 270         


Ile Leu Lys Gln Ile Asp Asn Lys Gln Leu Gln Gly Tyr Leu Ser Glu 
        275                 280                 285             


Leu Arg Pro Val Thr Ile Val Phe Val Asn Leu Met Phe Glu Asp Gln 
    290                 295                 300                 


Asp Lys Ala Glu Glu Ile Gly Pro Ala Ile Gln Asp Ala Tyr Met His 
305                 310                 315                 320 


Ile Thr Ser Val Leu Lys Ile Phe Gln Gly Gln Ile Asn Lys Val Phe 
                325                 330                 335     


Met Phe Asp Lys Gly Cys Ser Phe Leu Cys Val Phe Gly Phe Pro Gly 
            340                 345                 350         


Glu Lys Val Pro Asp Glu Leu Thr His Ala Leu Glu Cys Ala Met Asp 
        355                 360                 365             


Ile Phe Asp Phe Cys Ser Gln Val His Lys Ile Gln Thr Val Ser Ile 
    370                 375                 380                 


Gly Val Ala Ser Gly Ile Val Phe Cys Gly Ile Val Gly His Thr Val 
385                 390                 395                 400 


Arg His Glu Tyr Thr Val Ile Gly Gln Lys Val Asn Leu Ala Ala Arg 
                405                 410                 415     


Met Met Met Tyr Tyr Pro Gly Ile Val Thr Cys Asp Ser Val Thr Tyr 
            420                 425                 430         


Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu Leu Pro Lys Lys 
        435                 440                 445             


Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr Gln Tyr Trp Gly 
    450                 455                 460                 


Arg Thr Glu Lys Val Met 
465                 470 


<210>  3
<211>  50
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitopes of anti-sAC antibodies 
       R40 and R33

<400>  3

Met Phe Val Asp Ile Ser Gly Phe Thr Ala Met Thr Glu Lys Phe Ser 
1               5                   10                  15      


Ser Ala Met Tyr Met Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu 
            20                  25                  30          


Asn Tyr His Ile Ser Ala Ile Val Glu Lys Val Leu Ile Phe Gly Gly 
        35                  40                  45              


Asp Ile 
    50  


<210>  4
<211>  50
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitopes of anti-sAC antibodies 
       R7, R21, and R53

<400>  4

Asp Asp Val Arg Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile 
1               5                   10                  15      


Leu Ser Pro Asn Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile 
            20                  25                  30          


Glu Ser Val Pro Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro 
        35                  40                  45              


Pro Pro 
    50  


<210>  5
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitopes of anti-sAC antibodies 
       R5, R6.2, R14, R37, R41, R47.1, R52, R54, and R59

<400>  5

Ser Val Thr Tyr Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu 
1               5                   10                  15      


Leu Pro Lys Lys Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr 
            20                  25                  30          


Gln Tyr Trp Gly Arg Thr Glu Lys Val Met 
        35                  40          


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitope of antibody R33

<400>  6

Ala Met Tyr Met Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu Asn 
1               5                   10                  15      


<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitopes of anti-sAC antibodies 
       R7, R21, and R53

<400>  7

Glu Ile Glu Ser Val Pro Asp Gln Arg Ala Val Lys Val Asn 
1               5                   10                  


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitope of antibody R37

<400>  8

Glu Leu Pro Lys Lys Val Met Lys Gly Val Ala Asp Ser Gly Pro 
1               5                   10                  15  


<210>  9
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitopes of anti-sAC antibodies 
       R5 and R37

<400>  9

Asn Leu Pro Ala Tyr Phe Phe Lys Glu Leu Pro Lys Lys Val Met Lys 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  peptide sequence containing the epitopes of anti-sAC antibodies 
       R6.2, R14, R37, R41, R41.7, R52, R54, and R59

<400>  10

Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr Gln Tyr Trp Gly Arg 
1               5                   10                  15      


Thr 
    


