                         SEQUENCE LISTING

<110>  Medical Research Council
 
<120>  Methods

<130>  MEDBY/P48611PC

<150>  US 12/763005
<151>  2010-04-19

<150>  GB 1006502.7
<151>  2010-04-19

<150>  GB 1011010.4
<151>  2010-06-30

<150>  US 12/828674
<151>  2010-07-01

<160>  38    

<170>  PatentIn version 3.3

<210>  1
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Met Asp Lys Ser Glu Leu Val Gln Lys Ala Lys Leu Ala Glu 
1               5                   10                  15      


Gln Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Ala Val Thr 
            20                  25                  30          


Glu Gln Gly His Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val 
        35                  40                  45              


Ala Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile 
    50                  55                  60                  


Ser Ser Ile Glu Gln Lys Thr Glu Arg Asn Glu Lys Lys Gln Gln Met 
65                  70                  75                  80  


Gly Lys Glu Tyr Arg Glu Lys Ile Glu Ala Glu Leu Gln Asp Ile Cys 
                85                  90                  95      


Asn Asp Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Pro Asn Ala Thr 
            100                 105                 110         


Gln Pro Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe 
        115                 120                 125             


Arg Tyr Leu Ser Glu Val Ala Ser Gly Asp Asn Lys Gln Thr Thr Val 
    130                 135                 140                 


Ser Asn Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser 
            180                 185                 190         


Leu Ala Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu 
        195                 200                 205             


Asn Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ser Glu Asn Gln Gly Asp Glu Gly Asp 
225                 230                 235                 240 


Ala Gly Glu Gly Glu Asn 
                245     


<210>  2
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  2

Met Thr Met Asp Lys Ser Glu Leu Val Gln Lys Ala Lys Leu Ala Glu 
1               5                   10                  15      


Gln Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Ala Val Thr 
            20                  25                  30          


Glu Gln Gly His Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val 
        35                  40                  45              


Ala Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile 
    50                  55                  60                  


Ser Ser Ile Glu Gln Lys Thr Glu Arg Asn Glu Lys Lys Gln Gln Met 
65                  70                  75                  80  


Gly Lys Glu Tyr Arg Glu Lys Ile Glu Ala Glu Leu Gln Asp Ile Cys 
                85                  90                  95      


Asn Asp Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Leu Asn Ala Thr 
            100                 105                 110         


Gln Ala Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe 
        115                 120                 125             


Arg Tyr Leu Ser Glu Val Ala Ser Gly Glu Asn Lys Gln Thr Thr Val 
    130                 135                 140                 


Ser Asn Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser 
            180                 185                 190         


Leu Ala Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu 
        195                 200                 205             


Asn Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ser Glu Asn Gln Gly Asp Glu Gly Asp 
225                 230                 235                 240 


Ala Gly Glu Gly Glu Asn 
                245     


<210>  3
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  4
<211>  255
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Gln Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  5
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Asp Arg Glu Gln Leu Leu Gln Arg Ala Arg Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Asp Met Ala Ser Ala Met Lys Ala Val Thr Glu 
            20                  25                  30          


Leu Asn Glu Pro Leu Ser Asn Glu Asp Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Thr Met Ala Asp Gly Asn Glu Lys Lys Leu Glu 
65                  70                  75                  80  


Lys Val Lys Ala Tyr Arg Glu Lys Ile Glu Lys Glu Leu Glu Thr Val 
                85                  90                  95      


Cys Asn Asp Val Leu Ser Leu Leu Asp Lys Phe Leu Ile Lys Asn Cys 
            100                 105                 110         


Asn Asp Phe Gln Tyr Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly 
        115                 120                 125             


Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala Ser Gly Glu Lys Lys Asn 
    130                 135                 140                 


Ser Val Val Glu Ala Ser Glu Ala Ala Tyr Lys Glu Ala Phe Glu Ile 
145                 150                 155                 160 


Ser Lys Glu Gln Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala 
                165                 170                 175     


Leu Asn Phe Ser Val Phe Tyr Tyr Glu Ile Gln Asn Ala Pro Glu Gln 
            180                 185                 190         


Ala Cys Leu Leu Ala Lys Gln Ala Phe Asp Asp Ala Ile Ala Glu Leu 
        195                 200                 205             


Asp Thr Leu Asn Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln 
    210                 215                 220                 


Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Gln Gln Asp Glu 
225                 230                 235                 240 


Glu Ala Gly Glu Gly Asn 
                245     


<210>  6
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Asp Arg Glu Gln Leu Leu Gln Arg Ala Arg Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Asp Met Ala Ser Ala Met Lys Ala Val Thr Glu 
            20                  25                  30          


Leu Asn Glu Pro Leu Ser Asn Glu Asp Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Thr Met Ala Asp Gly Asn Glu Lys Lys Leu Glu 
65                  70                  75                  80  


Lys Val Lys Ala Tyr Arg Glu Lys Ile Glu Lys Glu Leu Glu Thr Val 
                85                  90                  95      


Cys Asn Asp Val Leu Ala Leu Leu Asp Lys Phe Leu Ile Lys Asn Cys 
            100                 105                 110         


Asn Asp Phe Gln Tyr Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly 
        115                 120                 125             


Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala Ser Gly Glu Lys Lys Asn 
    130                 135                 140                 


Ser Val Val Glu Ala Ser Glu Ala Ala Tyr Lys Glu Ala Phe Glu Ile 
145                 150                 155                 160 


Ser Lys Glu His Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala 
                165                 170                 175     


Leu Asn Phe Ser Val Phe Tyr Tyr Glu Ile Gln Asn Ala Pro Glu Gln 
            180                 185                 190         


Ala Cys Leu Leu Ala Lys Gln Ala Phe Asp Asp Ala Ile Ala Glu Leu 
        195                 200                 205             


Asp Thr Leu Asn Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln 
    210                 215                 220                 


Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Gln Gln Asp Glu 
225                 230                 235                 240 


Glu Ala Gly Glu Gly Asn 
                245     


<210>  7
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Asp Arg Glu Gln Leu Val Gln Lys Ala Arg Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Asn Val Thr Glu 
            20                  25                  30          


Leu Asn Glu Pro Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Thr Ser Ala Asp Gly Asn Glu Lys Lys Ile Glu 
65                  70                  75                  80  


Met Val Arg Ala Tyr Arg Glu Lys Ile Glu Lys Glu Leu Glu Ala Val 
                85                  90                  95      


Cys Gln Asp Val Leu Ser Leu Leu Asp Asn Tyr Leu Ile Lys Asn Cys 
            100                 105                 110         


Ser Glu Thr Gln Tyr Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly 
        115                 120                 125             


Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala Thr Gly Glu Lys Arg Ala 
    130                 135                 140                 


Thr Val Val Glu Ser Ser Glu Lys Ala Tyr Ser Glu Ala His Glu Ile 
145                 150                 155                 160 


Ser Lys Glu His Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala 
                165                 170                 175     


Leu Asn Tyr Ser Val Phe Tyr Tyr Glu Ile Gln Asn Ala Pro Glu Gln 
            180                 185                 190         


Ala Cys His Leu Ala Lys Thr Ala Phe Asp Asp Ala Ile Ala Glu Leu 
        195                 200                 205             


Asp Thr Leu Asn Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln 
    210                 215                 220                 


Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Gln Gln Asp Asp 
225                 230                 235                 240 


Asp Gly Gly Glu Gly Asn Asn 
                245         


<210>  8
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  8

Met Val Asp Arg Glu Gln Leu Val Gln Lys Ala Arg Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Asn Val Thr Glu 
            20                  25                  30          


Leu Asn Glu Pro Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Thr Ser Ala Asp Gly Asn Glu Lys Lys Ile Glu 
65                  70                  75                  80  


Met Val Arg Ala Tyr Arg Glu Lys Ile Glu Lys Glu Leu Glu Ala Val 
                85                  90                  95      


Cys Gln Asp Val Leu Ser Leu Leu Asp Asn Tyr Leu Ile Lys Asn Cys 
            100                 105                 110         


Ser Glu Thr Gln Tyr Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly 
        115                 120                 125             


Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala Thr Gly Glu Lys Arg Ala 
    130                 135                 140                 


Thr Val Val Glu Ser Ser Glu Lys Ala Tyr Ser Glu Ala His Glu Ile 
145                 150                 155                 160 


Ser Lys Glu His Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala 
                165                 170                 175     


Leu Asn Tyr Ser Val Phe Tyr Tyr Glu Ile Gln Asn Ala Pro Glu Gln 
            180                 185                 190         


Ala Cys His Leu Ala Lys Thr Ala Phe Asp Asp Ala Ile Ala Glu Leu 
        195                 200                 205             


Asp Thr Leu Asn Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln 
    210                 215                 220                 


Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Gln Gln Asp Asp 
225                 230                 235                 240 


Asp Gly Gly Glu Gly Asn Asn 
                245         


<210>  9
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                85                  90                  95      


Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Asp Asn 
    130                 135                 140                 


Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
        195                 200                 205             


Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
225                 230                 235                 240 


Glu Gly Ala Glu Asn 
                245 


<210>  10
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                85                  90                  95      


Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Glu Asn 
    130                 135                 140                 


Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
        195                 200                 205             


Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
225                 230                 235                 240 


Glu Gly Ala Glu Asn 
                245 


<210>  11
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  12
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  12

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  13
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Gly Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Arg Glu Tyr Arg Glu Lys Val Glu Thr Glu Leu Gln Gly Val Cys 
                85                  90                  95      


Asp Thr Val Leu Gly Leu Leu Asp Ser His Leu Ile Lys Glu Ala Gly 
            100                 105                 110         


Asp Ala Glu Ser Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
        115                 120                 125             


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
    130                 135                 140                 


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
            180                 185                 190         


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
        195                 200                 205             


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ala Asp Asn Ala Gly Glu Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Pro Gln Glu Pro Gln Ser 
                245             


<210>  14
<211>  248
<212>  PRT
<213>  Mus musculus

<400>  14

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Ser Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Lys Glu Tyr Arg Glu Lys Val Glu Thr Glu Leu Arg Gly Val Cys 
                85                  90                  95      


Asp Thr Val Leu Gly Leu Leu Asp Ser His Leu Ile Lys Gly Ala Gly 
            100                 105                 110         


Asp Ala Glu Ser Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
        115                 120                 125             


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
    130                 135                 140                 


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
            180                 185                 190         


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
        195                 200                 205             


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ala Asp Ser Ala Gly Glu Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Pro Glu Glu Pro Gln Ser 
                245             


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln 
1               5                   10                  15  


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly 
1               5                   10                  15      


Asn Thr Lys Gln Arg 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Leu Gly Trp Trp Arg Phe Tyr Thr Leu Arg Arg Ala Arg Gln Gly 
1               5                   10                  15      


Asn Thr Lys Gln Arg 
            20      


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  PHOSPHORYLATION

<400>  18

Val Lys Lys Lys Ser Asn Ser Ile Ser Val Gly Glu Phe Tyr 
1               5                   10                  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  19

Asn Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His 
1               5                   10                  15  


<210>  20
<211>  22
<212>  PRT
<213>  Mus musculus


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  20

Asn Thr Leu Gln Glu Gly Val Ala Ser Gly Ser Asp Gly Asn Phe Ser 
1               5                   10                  15      


Glu Asp Ala Leu Ala Lys 
            20          


<210>  21
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  21

Ser Asn Ser Ile Ser Val Gly Glu Val Tyr Arg 
1               5                   10      


<210>  22
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  22

Lys Ser Asn Ser Ile Ser Val Gly Glu Val Tyr Arg 
1               5                   10          


<210>  23
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  23

His Ser Asn Ser Leu Gly Pro Val Phe Asp His Glu Asp Leu Leu Arg 
1               5                   10                  15      


<210>  24
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  24

Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe Ser 
1               5                   10                  15      


Glu Asp Val Leu Ser Lys 
            20          


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  25

Ser Asn Ser Ile Ser Val Gly Glu Phe Tyr Arg 
1               5                   10      


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  26

Lys Ser Asn Ser Ile Ser Val Gly Glu Phe Tyr Arg 
1               5                   10          


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  27

His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp Leu Leu Lys 
1               5                   10                  15      


Arg 
    


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  28

Ile Leu Ser Ser Asp Asp Ser Leu Arg 
1               5                   


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  29

His Ser Asp Ser Ile Ser Ser Leu Ala Ser Glu Arg 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  PHOSPHORYLATION

<400>  30

His Ser Asp Ser Ile Ser Ser Leu Ala Ser Glu Arg 
1               5                   10          


<210>  31
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Lys Lys Ser Asn Ser Ile Ser Val Gly Glu Phe Tyr Arg Asp Ala 
1               5                   10                  15      


Val Leu Gln Arg Cys Ser Pro Asn Leu Gln Arg His Ser Asn Ser Leu 
            20                  25                  30          


Gly Pro Ile Phe Asp 
        35          


<210>  32
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  32

Lys Arg Lys Ser Asn Ser Ile Ser Val Gly Glu Val Tyr Arg Asp Leu 
1               5                   10                  15      


Ala Leu Gln Arg Tyr Ser Pro Asn Ala Gln Arg His Ser Asn Ser Leu 
            20                  25                  30          


Gly Pro Val Phe Asp 
        35          


<210>  33
<211>  37
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Lys Lys Lys Ser Asn Ser Val Ser Val Gly Glu Val Tyr Arg Asp Leu 
1               5                   10                  15      


Ala Leu Gln Arg Cys Ser Pro Asn Ala Gln Arg His Ser Ser Ser Leu 
            20                  25                  30          


Gly Pro Val Phe Asp 
        35          


<210>  34
<211>  37
<212>  PRT
<213>  Bos taurus

<400>  34

Lys Thr Lys Ser Asn Ser Ile Ser Val Gly Glu Phe Tyr Gln Asp Pro 
1               5                   10                  15      


Ala Leu Gln Arg Cys Ser Pro Asn Leu Gln Arg His Ser Ser Ser Leu 
            20                  25                  30          


Gly Pro Ile Phe Asp 
        35          


<210>  35
<211>  37
<212>  PRT
<213>  Canis familiaris

<400>  35

Lys Arg Lys Ser Asn Ser Ile Ser Val Gly Glu Phe Tyr His Asp Arg 
1               5                   10                  15      


Ala Leu Gln Arg Cys Ser Pro Asn Leu Gln Arg His Ser Asn Ser Leu 
            20                  25                  30          


Gly Pro Ile Phe Asp 
        35          


<210>  36
<211>  38
<212>  PRT
<213>  Gallus gallus

<400>  36

Lys Lys Lys Ser Asn Ser Ile Ala Val Ala Asp Leu His Cys Arg Glu 
1               5                   10                  15      


Leu Ala Phe Gln Arg Gly Ser Pro Thr Leu Pro Arg His Ser Tyr Ser 
            20                  25                  30          


Val Gly Pro Gly Ser Asp 
        35              


<210>  37
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Lys Lys Lys Ser Asn Ser Ile Ser Val Gly Glu Phe 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  38

Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp 
1               5                   10              


