                         SEQUENCE LISTING

<110>  Addex Pharma SA
       Gjoni, Tina
       Dominik, Schelshorn
       Hampe, Cornelia
       Gouiller, Aurlie
       Ltjens, Robert
 
<120>  Chimeric Polypeptides Useful in Proximal and Dynamic 
       High-Throughput Screening Methods

<130>  ADD-2P-EP

<150>  EP10160519.4
<151>  2010-04-20

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  963
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated Luciferase

<400>  1
atgaccagca aggtgtacga ccccgagcag aggaagagga tgatcaccgg cccccagtgg       60

tgggccaggt gcaagcagat gaacgtgctg gacagcttca tcaactacta cgacagcgag      120

aagcacgccg agaacgccgt gatcttcctg cacggcaacg ccaccagcag ctacctgtgg      180

aggcacgtgg tgccccacat cgagcccgtg gccaggtgca tcatccccga tctgatcggc      240

atgggcaaga gcggcaagag cggcaacggc agctacaggc tgctggacca ctacaagtac      300

ctgaccgcct ggttcgagct cctgaacctg cccaagaaga tcatcttcgt gggccacgac      360

tggggagctg cactggcctt ccactacgcc tacgagcacc aggacagaat caaggccatc      420

gtgcacatgg agagcgtggt ggacgtgatc gagagctggg acgagtggcc agacatcgag      480

gaggacatcg ccctgatcaa gagcgaggag ggcgagaaga tggtgctgga gaacaacttc      540

ttcgtggaga ccgtcctgcc cagcaagatc atgagaaagc tggagcccga ggagttcgcc      600

gcctacctgg agcccttcaa ggagaagggc gaggtgagaa gacccaccct gagctggccc      660

agagagatcc ccctggtgaa gggcggcaag cccgacgtgg tgcagatcgt gagaaactac      720

aacgcctacc tgagagccag cgacgacctg cccaagctgt tcatcgagag cgaccccggc      780

ttcttcagca acgccatcgt ggagggcgcc aagaagttcc ccaacaccga gttcgtgaag      840

gtgaagggcc tgcactttct ccaggaagac gcccccgacg agatgggcaa gtacatcaag      900

agcttcgtgg agagagtgct gaagaacgag caagccgact acaaggatga cgatgacaag      960

taa                                                                    963


<210>  2
<211>  714
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated fluorescent protein

<400>  2
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagct gctgtgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgggcta cggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagct accagtccgc cctgttcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcctgaccgc cgccgggatc actgagggca tgaacgagct gtac            714


<210>  3
<211>  924
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein FP-Gg9 encoding DNA

<400>  3
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagct gctgtgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgggcta cggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagct accagtccgc cctgttcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcctgaccgc cgccgggatc actgagggca tgaacgagct gtacatggcc      720

caggatctca gcgagaagga cctgttgaag atggaggtgg agcagctgaa gaaagaagtg      780

aaaaacacaa gaattccgat ttccaaagcg ggaaaggaaa tcaaggagta cgtggaggcc      840

caagcaggaa acgatccttt tctcaaaggc atccctgagg acaagaatcc cttcaaggag      900

aaaggtggct gtctgataag ctga                                             924


<210>  4
<211>  307
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein FP-Gg9

<400>  4

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Leu 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Phe Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Leu Thr Ala Ala Gly Ile Thr Glu Gly Met Asn Glu Leu Tyr Met Ala 
225                 230                 235                 240 


Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val Glu Gln Leu 
                245                 250                 255     


Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala Gly Lys 
            260                 265                 270         


Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro Phe Leu 
        275                 280                 285             


Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly Gly Cys 
    290                 295                 300                 


Leu Ile Ser 
305         


<210>  5
<211>  924
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein Gg9-FP encoding DNA

<400>  5
atggcccagg atctcagcga gaaggacctg ttgaagatgg aggtggagca gctgaagaaa       60

gaagtgaaaa acacaagaat tccgatttcc aaagcgggaa aggaaatcaa ggagtacgtg      120

gaggcccaag caggaaacga tccttttctc aaaggcatcc ctgaggacaa gaatcccttc      180

aaggagaaag gtggctgtct gataagcatg gtgagcaagg gcgaggagct gttcaccggg      240

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc      300

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagctgct gtgcaccacc      360

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgggctacgg cgtgcagtgc      420

ttcgcccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa      480

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc      540

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc      600

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc      660

tatatcaccg ccgacaagca gaagaacggc atcaaggcca acttcaagat ccgccacaac      720

atcgaggacg gcggcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac      780

ggccccgtgc tgctgcccga caaccactac ctgagctacc agtccgccct gttcaaagac      840

cccaacgaga agcgcgatca catggtcctg ctggagttcc tgaccgccgc cgggatcact      900

gagggcatga acgagctgta ctga                                             924


<210>  6
<211>  307
<212>  PRT
<213>  Artificial

<220>
<223>  Gg9-FP fusion protein

<400>  6

Met Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val Glu 
1               5                   10                  15      


Gln Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala 
            20                  25                  30          


Gly Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro 
        35                  40                  45              


Phe Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly 
    50                  55                  60                  


Gly Cys Leu Ile Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
65                  70                  75                  80  


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
                85                  90                  95      


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
            100                 105                 110         


Thr Leu Lys Leu Leu Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
        115                 120                 125             


Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr 
    130                 135                 140                 


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
145                 150                 155                 160 


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
                165                 170                 175     


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
            180                 185                 190         


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
        195                 200                 205             


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala 
    210                 215                 220                 


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
225                 230                 235                 240 


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
                245                 250                 255     


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
            260                 265                 270         


Tyr Gln Ser Ala Leu Phe Lys Asp Pro Asn Glu Lys Arg Asp His Met 
        275                 280                 285             


Val Leu Leu Glu Phe Leu Thr Ala Ala Gly Ile Thr Glu Gly Met Asn 
    290                 295                 300                 


Glu Leu Tyr 
305         


<210>  7
<211>  3555
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein GLP1R-L-G (RLG) encoding DNA

<400>  7
atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg       60

gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga      120

gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg      180

ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc      240

gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg      300

taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg      360

agggacttgt cggagtgcga ggagtccaag cgaggggaga gaagctcccc ggaggagcag      420

ctcctgttcc tctacatcat ctacacggtg ggctacgcac tctccttctc tgctctggtt      480

atcgcctctg cgatcctcct cggcttcaga cacctgcact gcaccaggaa ctacatccac      540

ctgaacctgt ttgcatcctt catcctgcga gcattgtccg tcttcatcaa ggacgcagcc      600

ctgaagtgga tgtatagcac agccgcccag cagcaccagt gggatgggct cctctcctac      660

caggactctc tgagctgccg cctggtgttt ctgctcatgc agtactgtgt ggcggccaat      720

tactactggc tcttggtgga gggcgtgtac ctgtacacac tgctggcctt ctcggtctta      780

tctgagcaat ggatcttcag gctctacgtg agcataggct ggggtgttcc cctgctgttt      840

gttgtcccct ggggcattgt caagtacctc tatgaggacg agggctgctg gaccaggaac      900

tccaacatga actactggct cattatccgg ctgcccattc tctttgccat tggggtgaac      960

ttcctcatct ttgttcgggt catctgcatc gtggtatcca aactgaaggc caatctcatg     1020

tgcaagacag acatcaaatg cagacttgcc aagtccacgc tgacactcat ccccctgctg     1080

gggactcatg aggtcatctt tgcctttgtg atggacgagc acgcccgggg gaccctgcgc     1140

ttcatcaagc tgtttacaga gctctccttc acctccttcc aggggctgat ggtggccata     1200

ttatactgct ttgtcaacaa tgaggtccag ctggaatttc ggaagagctg ggagcgctgg     1260

cggcttgagc acttgcacat ccagagggac agcagcatga agcccctcaa gtgtcccacc     1320

agcagcctga gcagtggagc cacggcgggc agcagcatgt acacagccac ttgccaggcc     1380

tcctgcagcc acccaacttt tctatacaaa gttgccatga ccagcaaggt gtacgacccc     1440

gagcagagga agaggatgat caccggcccc cagtggtggg ccaggtgcaa gcagatgaac     1500

gtgctggaca gcttcatcaa ctactacgac agcgagaagc acgccgagaa cgccgtgatc     1560

ttcctgcacg gcaacgccac cagcagctac ctgtggaggc acgtggtgcc ccacatcgag     1620

cccgtggcca ggtgcatcat ccccgatctg atcggcatgg gcaagagcgg caagagcggc     1680

aacggcagct acaggctgct ggaccactac aagtacctga ccgcctggtt cgagctcctg     1740

aacctgccca agaagatcat cttcgtgggc cacgactggg gagctgcact ggccttccac     1800

tacgcctacg agcaccagga cagaatcaag gccatcgtgc acatggagag cgtggtggac     1860

gtgatcgaga gctgggacga gtggccagac atcgaggagg acatcgccct gatcaagagc     1920

gaggagggcg agaagatggt gctggagaac aacttcttcg tggagaccgt cctgcccagc     1980

aagatcatga gaaagctgga gcccgaggag ttcgccgcct acctggagcc cttcaaggag     2040

aagggcgagg tgagaagacc caccctgagc tggcccagag agatccccct ggtgaagggc     2100

ggcaagcccg acgtggtgca gatcgtgaga aactacaacg cctacctgag agccagcgac     2160

gacctgccca agctgttcat cgagagcgac cccggcttct tcagcaacgc catcgtggag     2220

ggcgccaaga agttccccaa caccgagttc gtgaaggtga agggcctgca ctttctccag     2280

gaagacgccc ccgacgagat gggcaagtac atcaagagct tcgtggagag agtgctgaag     2340

aacgagacaa ctttgtataa taaagttgcc atgggctgcc tcgggaacag taagaccgag     2400

gaccagcgca acgaggagaa ggcgcagcgt gaggccaaca aaaagatcga gaagcagctg     2460

cagaaggaca agcaggtcta ccgggccacg caccgcctgc tgctgctggg tgctggagaa     2520

tctggtaaaa gcaccattgt gaagcagatg aggatcctgc atgttaatgg gtttaatgga     2580

gagggcggcg aagaggaccc gcaggctgca aggagcaaca gcgatggtga gaaggcaacc     2640

aaagtgcagg acatcaaaaa caacctgaaa gaggcgattg aaaccattgt ggccgccatg     2700

agcaacctgg tgccccccgt ggagctggcc aaccccgaga accagttcag agtggactac     2760

attctgagtg tgatgaacgt gcctgacttt gacttccctc ccgaattcta tgagcatgcc     2820

aaggctctgt gggaggatga aggagtgcgt gcctgctacg aacgctccaa cgagtaccag     2880

ctgattgact gtgcccagta cttcctggac aagatcgacg tgatcaagca ggctgactat     2940

gtgccgagcg atcaggacct gcttcgctgc cgtgtcctga cttctggaat ctttgagacc     3000

aagttccagg tggacaaagt caacttccac atgtttgacg tgggtggcca gcgcgatgaa     3060

cgccgcaagt ggatccagtg cttcaacgat gtgactgcca tcatcttcgt ggtggccagc     3120

agcagctaca acatggtcat ccgggaggac aaccagacca accgcctgca ggaggctctg     3180

aacctcttca agagcatctg gaacaacaga tggctgcgca ccatctctgt gatcctgttc     3240

ctcaacaagc aagatctgct cgctgagaaa gtccttgctg ggaaatcgaa gattgaggac     3300

tactttccag aatttgctcg ctacactact cctgaggatg ctactcccga gcccggagag     3360

gacccacgcg tgacccgggc caagtacttc attcgagatg agtttctgag gatcagcact     3420

gccagtggag atgggcgtca ctactgctac cctcatttca cctgcgctgt ggacactgag     3480

aacatccgcc gtgtgttcaa cgactgccgt gacatcattc agcgcatgca ccttcgtcag     3540

tacgagctgc tctaa                                                      3555


<210>  8
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  GLP1R-L-G (RLG)  fusion protein

<400>  8

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser His 
    450                 455                 460                 


Pro Thr Phe Leu Tyr Lys Val Ala Met Thr Ser Lys Val Tyr Asp Pro 
465                 470                 475                 480 


Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys 
                485                 490                 495     


Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu 
            500                 505                 510         


Lys His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala Thr Ser 
        515                 520                 525             


Ser Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro Val Ala Arg 
    530                 535                 540                 


Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly 
545                 550                 555                 560 


Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp 
                565                 570                 575     


Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp 
            580                 585                 590         


Trp Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu His Gln Asp Arg 
        595                 600                 605             


Ile Lys Ala Ile Val His Met Glu Ser Val Val Asp Val Ile Glu Ser 
    610                 615                 620                 


Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser 
625                 630                 635                 640 


Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr 
                645                 650                 655     


Val Leu Pro Ser Lys Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala 
            660                 665                 670         


Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr 
        675                 680                 685             


Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp 
    690                 695                 700                 


Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp 
705                 710                 715                 720 


Asp Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn 
                725                 730                 735     


Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys 
            740                 745                 750         


Val Lys Gly Leu His Phe Leu Gln Glu Asp Ala Pro Asp Glu Met Gly 
        755                 760                 765             


Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn Glu Thr Thr 
    770                 775                 780                 


Leu Tyr Asn Lys Val Ala Met Gly Cys Leu Gly Asn Ser Lys Thr Glu 
785                 790                 795                 800 


Asp Gln Arg Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile 
                805                 810                 815     


Glu Lys Gln Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg 
            820                 825                 830         


Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys 
        835                 840                 845             


Gln Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu 
    850                 855                 860                 


Glu Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr 
865                 870                 875                 880 


Lys Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile 
                885                 890                 895     


Val Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro 
            900                 905                 910         


Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro 
        915                 920                 925             


Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp 
    930                 935                 940                 


Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln 
945                 950                 955                 960 


Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys 
                965                 970                 975     


Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val 
            980                 985                 990         


Leu Thr Ser Gly Ile Phe Glu Thr  Lys Phe Gln Val Asp  Lys Val Asn 
        995                 1000                 1005             


Phe His  Met Phe Asp Val Gly  Gly Gln Arg Asp Glu  Arg Arg Lys 
    1010                 1015                 1020             


Trp Ile  Gln Cys Phe Asn Asp  Val Thr Ala Ile Ile  Phe Val Val 
    1025                 1030                 1035             


Ala Ser  Ser Ser Tyr Asn Met  Val Ile Arg Glu Asp  Asn Gln Thr 
    1040                 1045                 1050             


Asn Arg  Leu Gln Glu Ala Leu  Asn Leu Phe Lys Ser  Ile Trp Asn 
    1055                 1060                 1065             


Asn Arg  Trp Leu Arg Thr Ile  Ser Val Ile Leu Phe  Leu Asn Lys 
    1070                 1075                 1080             


Gln Asp  Leu Leu Ala Glu Lys  Val Leu Ala Gly Lys  Ser Lys Ile 
    1085                 1090                 1095             


Glu Asp  Tyr Phe Pro Glu Phe  Ala Arg Tyr Thr Thr  Pro Glu Asp 
    1100                 1105                 1110             


Ala Thr  Pro Glu Pro Gly Glu  Asp Pro Arg Val Thr  Arg Ala Lys 
    1115                 1120                 1125             


Tyr Phe  Ile Arg Asp Glu Phe  Leu Arg Ile Ser Thr  Ala Ser Gly 
    1130                 1135                 1140             


Asp Gly  Arg His Tyr Cys Tyr  Pro His Phe Thr Cys  Ala Val Asp 
    1145                 1150                 1155             


Thr Glu  Asn Ile Arg Arg Val  Phe Asn Asp Cys Arg  Asp Ile Ile 
    1160                 1165                 1170             


Gln Arg  Met His Leu Arg Gln  Tyr Glu Leu Leu 
    1175                 1180                 


<210>  9
<211>  3564
<212>  DNA
<213>  Artificial

<220>
<223>  GIPR-L-G (RLG) fusion protein encoding DNA

<400>  9
atgactacct ctccgatcct gcagctgctg ctgcggctct cactgtgcgg gctgctgctc       60

cagagggcgg agacaggctc taaggggcag acggcggggg agctgtacca gcgctgggaa      120

cggtaccgca gggagtgcca ggagaccttg gcagccgcgg aaccgccttc aggcctcgcc      180

tgtaacgggt ccttcgatat gtacgtctgc tgggactatg ctgcacccaa tgccactgcc      240

cgtgcgtcct gcccctggta cctgccctgg caccaccatg tggctgcagg tttcgtcctc      300

cgccagtgtg gtagtgatgg ccaatgggga ctttggagag accatacaca atgtgagaac      360

ccagagaaga atgaggcctt tctggaccaa aggctcatct tggagcggtt gcaggtcatg      420

tacactgtcg gctactccct gtctctcgcc acactgctgc tagccctgct catcttgagt      480

ttgttcaggc ggctacattg cactagaaac tatatccaca tcaacctgtt cacgtctttc      540

atgctgcgag ctgcggccat tctcagccga gaccgtctgc tacctcgacc tggcccctac      600

cttggggacc aggcccttgc gctgtggaac caggccctcg ctgcctgccg cacggcccag      660

atcgtgaccc agtactgcgt gggtgccaac tacacgtggc tgctggtgga gggcgtctac      720

ctgcacagtc tcctggtgct cgtgggaggc tccgaggagg gccacttccg ctactacctg      780

ctcctcggct ggggggcccc cgcgcttttc gtcattccct gggtgatcgt caggtacctg      840

tacgagaaca cgcagtgctg ggagcgcaac gaagtcaagg ccatttggtg gattatacgg      900

acccccatcc tcatgaccat cttgattaat ttcctcattt ttatccgcat tcttggcatt      960

ctcctgtcca agctgaggac acggcaaatg cgctgccggg attaccggct gaggctggct     1020

cgctccacgc tgacgctggt gcccctgctg ggtgtccacg aggtggtgtt tgctcccgtg     1080

acagaggaac aggcccgggg cgccctgcgc ttcgccaagc tcggctttga gatcttcctc     1140

agctccttcc agggcttcct ggtcagcgtc ctctactgct tcatcaacaa ggaggtgcag     1200

tcggagatcc gccgtggctg gcaccactgc cgcctgcgcc gcagcctggg cgaggagcaa     1260

cgccagctcc cggagcgcgc cttccgggcc ctgccctccg gctccggccc gggcgaggtc     1320

cccaccagcc gcggcttgtc ctcggggacc ctcccagggc ctgggaatga ggccagccgg     1380

gagttggaaa gttactgcca cccaactttt ctatacaaag ttgccatgac cagcaaggtg     1440

tacgaccccg agcagaggaa gaggatgatc accggccccc agtggtgggc caggtgcaag     1500

cagatgaacg tgctggacag cttcatcaac tactacgaca gcgagaagca cgccgagaac     1560

gccgtgatct tcctgcacgg caacgccacc agcagctacc tgtggaggca cgtggtgccc     1620

cacatcgagc ccgtggccag gtgcatcatc cccgatctga tcggcatggg caagagcggc     1680

aagagcggca acggcagcta caggctgctg gaccactaca agtacctgac cgcctggttc     1740

gagctcctga acctgcccaa gaagatcatc ttcgtgggcc acgactgggg agctgcactg     1800

gccttccact acgcctacga gcaccaggac agaatcaagg ccatcgtgca catggagagc     1860

gtggtggacg tgatcgagag ctgggacgag tggccagaca tcgaggagga catcgccctg     1920

atcaagagcg aggagggcga gaagatggtg ctggagaaca acttcttcgt ggagaccgtc     1980

ctgcccagca agatcatgag aaagctggag cccgaggagt tcgccgccta cctggagccc     2040

ttcaaggaga agggcgaggt gagaagaccc accctgagct ggcccagaga gatccccctg     2100

gtgaagggcg gcaagcccga cgtggtgcag atcgtgagaa actacaacgc ctacctgaga     2160

gccagcgacg acctgcccaa gctgttcatc gagagcgacc ccggcttctt cagcaacgcc     2220

atcgtggagg gcgccaagaa gttccccaac accgagttcg tgaaggtgaa gggcctgcac     2280

tttctccagg aagacgcccc cgacgagatg ggcaagtaca tcaagagctt cgtggagaga     2340

gtgctgaaga acgagacaac tttgtataat aaagttgcca tgggctgcct cgggaacagt     2400

aagaccgagg accagcgcaa cgaggagaag gcgcagcgtg aggccaacaa aaagatcgag     2460

aagcagctgc agaaggacaa gcaggtctac cgggccacgc accgcctgct gctgctgggt     2520

gctggagaat ctggtaaaag caccattgtg aagcagatga ggatcctgca tgttaatggg     2580

tttaatggag agggcggcga agaggacccg caggctgcaa ggagcaacag cgatggtgag     2640

aaggcaacca aagtgcagga catcaaaaac aacctgaaag aggcgattga aaccattgtg     2700

gccgccatga gcaacctggt gccccccgtg gagctggcca accccgagaa ccagttcaga     2760

gtggactaca ttctgagtgt gatgaacgtg cctgactttg acttccctcc cgaattctat     2820

gagcatgcca aggctctgtg ggaggatgaa ggagtgcgtg cctgctacga acgctccaac     2880

gagtaccagc tgattgactg tgcccagtac ttcctggaca agatcgacgt gatcaagcag     2940

gctgactatg tgccgagcga tcaggacctg cttcgctgcc gtgtcctgac ttctggaatc     3000

tttgagacca agttccaggt ggacaaagtc aacttccaca tgtttgacgt gggtggccag     3060

cgcgatgaac gccgcaagtg gatccagtgc ttcaacgatg tgactgccat catcttcgtg     3120

gtggccagca gcagctacaa catggtcatc cgggaggaca accagaccaa ccgcctgcag     3180

gaggctctga acctcttcaa gagcatctgg aacaacagat ggctgcgcac catctctgtg     3240

atcctgttcc tcaacaagca agatctgctc gctgagaaag tccttgctgg gaaatcgaag     3300

attgaggact actttccaga atttgctcgc tacactactc ctgaggatgc tactcccgag     3360

cccggagagg acccacgcgt gacccgggcc aagtacttca ttcgagatga gtttctgagg     3420

atcagcactg ccagtggaga tgggcgtcac tactgctacc ctcatttcac ctgcgctgtg     3480

gacactgaga acatccgccg tgtgttcaac gactgccgtg acatcattca gcgcatgcac     3540

cttcgtcagt acgagctgct ctaa                                            3564


<210>  10
<211>  1187
<212>  PRT
<213>  Artificial

<220>
<223>  GIPR-L-G (RLG) fusion protein

<400>  10

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys His Pro Thr Phe Leu Tyr Lys Val Ala Met Thr Ser Lys Val 
465                 470                 475                 480 


Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp 
                485                 490                 495     


Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr 
            500                 505                 510         


Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn 
        515                 520                 525             


Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro 
    530                 535                 540                 


Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly 
545                 550                 555                 560 


Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu 
                565                 570                 575     


Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val 
            580                 585                 590         


Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu His 
        595                 600                 605             


Gln Asp Arg Ile Lys Ala Ile Val His Met Glu Ser Val Val Asp Val 
    610                 615                 620                 


Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu 
625                 630                 635                 640 


Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn Phe Phe 
                645                 650                 655     


Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu Glu Pro Glu 
            660                 665                 670         


Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu Val Arg 
        675                 680                 685             


Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys Gly Gly 
    690                 695                 700                 


Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg 
705                 710                 715                 720 


Ala Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro Gly Phe 
                725                 730                 735     


Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu 
            740                 745                 750         


Phe Val Lys Val Lys Gly Leu His Phe Leu Gln Glu Asp Ala Pro Asp 
        755                 760                 765             


Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn 
    770                 775                 780                 


Glu Thr Thr Leu Tyr Asn Lys Val Ala Met Gly Cys Leu Gly Asn Ser 
785                 790                 795                 800 


Lys Thr Glu Asp Gln Arg Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn 
                805                 810                 815     


Lys Lys Ile Glu Lys Gln Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala 
            820                 825                 830         


Thr His Arg Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        835                 840                 845             


Ile Val Lys Gln Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu 
    850                 855                 860                 


Gly Gly Glu Glu Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu 
865                 870                 875                 880 


Lys Ala Thr Lys Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile 
                885                 890                 895     


Glu Thr Ile Val Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu 
            900                 905                 910         


Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met 
        915                 920                 925             


Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys 
    930                 935                 940                 


Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn 
945                 950                 955                 960 


Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp 
                965                 970                 975     


Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg 
            980                 985                 990         


Cys Arg Val Leu Thr Ser Gly Ile  Phe Glu Thr Lys Phe  Gln Val Asp 
        995                 1000                 1005             


Lys Val  Asn Phe His Met Phe  Asp Val Gly Gly Gln  Arg Asp Glu 
    1010                 1015                 1020             


Arg Arg  Lys Trp Ile Gln Cys  Phe Asn Asp Val Thr  Ala Ile Ile 
    1025                 1030                 1035             


Phe Val  Val Ala Ser Ser Ser  Tyr Asn Met Val Ile  Arg Glu Asp 
    1040                 1045                 1050             


Asn Gln  Thr Asn Arg Leu Gln  Glu Ala Leu Asn Leu  Phe Lys Ser 
    1055                 1060                 1065             


Ile Trp  Asn Asn Arg Trp Leu  Arg Thr Ile Ser Val  Ile Leu Phe 
    1070                 1075                 1080             


Leu Asn  Lys Gln Asp Leu Leu  Ala Glu Lys Val Leu  Ala Gly Lys 
    1085                 1090                 1095             


Ser Lys  Ile Glu Asp Tyr Phe  Pro Glu Phe Ala Arg  Tyr Thr Thr 
    1100                 1105                 1110             


Pro Glu  Asp Ala Thr Pro Glu  Pro Gly Glu Asp Pro  Arg Val Thr 
    1115                 1120                 1125             


Arg Ala  Lys Tyr Phe Ile Arg  Asp Glu Phe Leu Arg  Ile Ser Thr 
    1130                 1135                 1140             


Ala Ser  Gly Asp Gly Arg His  Tyr Cys Tyr Pro His  Phe Thr Cys 
    1145                 1150                 1155             


Ala Val  Asp Thr Glu Asn Ile  Arg Arg Val Phe Asn  Asp Cys Arg 
    1160                 1165                 1170             


Asp Ile  Ile Gln Arg Met His  Leu Arg Gln Tyr Glu  Leu Leu 
    1175                 1180                 1185         


<210>  11
<211>  3402
<212>  DNA
<213>  Artificial

<220>
<223>  A2AR-L-G (RLG) fusion protein encoding DNA

<400>  11
atgcccatca tgggctcctc ggtgtacatc acggtggagc tggccattgc tgtgctggcc       60

atcctgggca atgtgctggt gtgctgggcc gtgtggctca acagcaacct gcagaacgtc      120

accaactact ttgtggtgtc actggcggcg gccgacatcg cagtgggtgt gctcgccatc      180

ccctttgcca tcaccatcag caccgggttc tgcgctgcct gccacggctg cctcttcatt      240

gcctgcttcg tcctggtcct cacgcagagc tccatcttca gtctcctggc catcgccatt      300

gaccgctaca ttgccatccg catcccgctc cggtacaatg gcttggtgac cggcacgagg      360

gctaagggca tcattgccat ctgctgggtg ctgtcgtttg ccatcggcct gactcccatg      420

ctaggttgga acaactgcgg tcagccaaag gagggcaaga accactccca gggctgcggg      480

gagggccaag tggcctgtct ctttgaggat gtggtcccca tgaactacat ggtgtacttc      540

aacttctttg cctgtgtgct ggtgcccctg ctgctcatgc tgggtgtcta tttgcggatc      600

ttcctggcgg cgcgacgaca gctgaagcag atggagagcc agcctctgcc gggggagcgg      660

gcacggtcca cactgcagaa ggaggtccat gctgccaagt cactggccat cattgtgggg      720

ctctttgccc tctgctggct gcccctacac atcatcaact gcttcacttt cttctgcccc      780

gactgcagcc acgcccctct ctggctcatg tacctggcca tcgtcctctc ccacaccaat      840

tcggttgtga atcccttcat ctacgcctac cgtatccgcg agttccgcca gaccttccgc      900

aagatcattc gcagccacgt cctgaggcag caagaacctt tcaaggcagc tggcaccagt      960

gcccgggtct tggcagctca tggcagtgac ggagagcagg tcagcctccg tctcaacggc     1020

cacccgccag gagtgtgggc caacggcagt gctccccacc ctgagcggag gcccaatggc     1080

tatgccctgg ggctggtgag tggagggagt gcccaagagt cccaggggaa cacgggcctc     1140

ccagacgtgg agctccttag ccatgagctc aagggagtgt gcccagagcc ccctggccta     1200

gatgaccccc tggcccagga tggagcagga gtgtcccacc caacttttct atacaaagtt     1260

gccatgacca gcaaggtgta cgaccccgag cagaggaaga ggatgatcac cggcccccag     1320

tggtgggcca ggtgcaagca gatgaacgtg ctggacagct tcatcaacta ctacgacagc     1380

gagaagcacg ccgagaacgc cgtgatcttc ctgcacggca acgccaccag cagctacctg     1440

tggaggcacg tggtgcccca catcgagccc gtggccaggt gcatcatccc cgatctgatc     1500

ggcatgggca agagcggcaa gagcggcaac ggcagctaca ggctgctgga ccactacaag     1560

tacctgaccg cctggttcga gctcctgaac ctgcccaaga agatcatctt cgtgggccac     1620

gactggggag ctgcactggc cttccactac gcctacgagc accaggacag aatcaaggcc     1680

atcgtgcaca tggagagcgt ggtggacgtg atcgagagct gggacgagtg gccagacatc     1740

gaggaggaca tcgccctgat caagagcgag gagggcgaga agatggtgct ggagaacaac     1800

ttcttcgtgg agaccgtcct gcccagcaag atcatgagaa agctggagcc cgaggagttc     1860

gccgcctacc tggagccctt caaggagaag ggcgaggtga gaagacccac cctgagctgg     1920

cccagagaga tccccctggt gaagggcggc aagcccgacg tggtgcagat cgtgagaaac     1980

tacaacgcct acctgagagc cagcgacgac ctgcccaagc tgttcatcga gagcgacccc     2040

ggcttcttca gcaacgccat cgtggagggc gccaagaagt tccccaacac cgagttcgtg     2100

aaggtgaagg gcctgcactt tctccaggaa gacgcccccg acgagatggg caagtacatc     2160

aagagcttcg tggagagagt gctgaagaac gagacaactt tgtataataa agttgccatg     2220

ggctgcctcg ggaacagtaa gaccgaggac cagcgcaacg aggagaaggc gcagcgtgag     2280

gccaacaaaa agatcgagaa gcagctgcag aaggacaagc aggtctaccg ggccacgcac     2340

cgcctgctgc tgctgggtgc tggagaatct ggtaaaagca ccattgtgaa gcagatgagg     2400

atcctgcatg ttaatgggtt taatggagag ggcggcgaag aggacccgca ggctgcaagg     2460

agcaacagcg atggtgagaa ggcaaccaaa gtgcaggaca tcaaaaacaa cctgaaagag     2520

gcgattgaaa ccattgtggc cgccatgagc aacctggtgc cccccgtgga gctggccaac     2580

cccgagaacc agttcagagt ggactacatc ctgagtgtga tgaacgtgcc tgactttgac     2640

ttccctcccg aattctatga gcatgccaag gctctgtggg aggatgaagg agtgcgtgcc     2700

tgctacgaac gctccaacga gtaccagctg attgactgtg cccagtactt cctggacaag     2760

atcgacgtga tcaagcaggc tgactatgtg ccgagcgatc aggacctgct tcgctgccgt     2820

gtcctgactt ctggaatctt tgagaccaag ttccaggtgg acaaagtcaa cttccacatg     2880

tttgacgtgg gtggccagcg cgatgaacgc cgcaagtgga tccagtgctt caacgatgtg     2940

actgccatca tcttcgtggt ggccagcagc agctacaaca tggtcatccg ggaggacaac     3000

cagaccaacc gcctgcagga ggctctgaac ctcttcaaga gcatctggaa caacagatgg     3060

ctgcgcacca tctctgtgat cctgttcctc aacaagcaag atctgctcgc tgagaaagtc     3120

cttgctggga aatcgaagat tgaggactac tttccagaat ttgctcgcta cactactcct     3180

gaggatgcta ctcccgagcc cggagaggac ccacgcgtga cccgggccaa gtacttcatt     3240

cgagatgagt ttctgaggat cagcactgcc agtggagatg ggcgtcacta ctgctaccct     3300

catttcacct gcgctgtgga cactgagaac atccgccgtg tgttcaacga ctgccgtgac     3360

atcattcagc gcatgcacct tcgtcagtac gagctgctct aa                        3402


<210>  12
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  A2AR-L-G (RLG) fusion protein

<400>  12

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Thr Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser His Pro Thr Phe 
                405                 410                 415     


Leu Tyr Lys Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg 
            420                 425                 430         


Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met 
        435                 440                 445             


Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala 
    450                 455                 460                 


Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser Tyr Leu 
465                 470                 475                 480 


Trp Arg His Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile 
                485                 490                 495     


Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser 
            500                 505                 510         


Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu 
        515                 520                 525             


Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala 
    530                 535                 540                 


Ala Leu Ala Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile Lys Ala 
545                 550                 555                 560 


Ile Val His Met Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu 
                565                 570                 575     


Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly 
            580                 585                 590         


Glu Lys Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro 
        595                 600                 605             


Ser Lys Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu 
    610                 615                 620                 


Glu Pro Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp 
625                 630                 635                 640 


Pro Arg Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln 
                645                 650                 655     


Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro 
            660                 665                 670         


Lys Leu Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val 
        675                 680                 685             


Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly 
    690                 695                 700                 


Leu His Phe Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile 
705                 710                 715                 720 


Lys Ser Phe Val Glu Arg Val Leu Lys Asn Glu Thr Thr Leu Tyr Asn 
                725                 730                 735     


Lys Val Ala Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg 
            740                 745                 750         


Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln 
        755                 760                 765             


Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu 
    770                 775                 780                 


Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg 
785                 790                 795                 800 


Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro 
                805                 810                 815     


Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln 
            820                 825                 830         


Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala 
        835                 840                 845             


Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln 
    850                 855                 860                 


Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp 
865                 870                 875                 880 


Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu 
                885                 890                 895     


Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
            900                 905                 910         


Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp 
        915                 920                 925             


Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
    930                 935                 940                 


Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met 
945                 950                 955                 960 


Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
                965                 970                 975     


Phe Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr 
            980                 985                 990         


Asn Met Val Ile Arg Glu Asp Asn  Gln Thr Asn Arg Leu  Gln Glu Ala 
        995                 1000                 1005             


Leu Asn  Leu Phe Lys Ser Ile  Trp Asn Asn Arg Trp  Leu Arg Thr 
    1010                 1015                 1020             


Ile Ser  Val Ile Leu Phe Leu  Asn Lys Gln Asp Leu  Leu Ala Glu 
    1025                 1030                 1035             


Lys Val  Leu Ala Gly Lys Ser  Lys Ile Glu Asp Tyr  Phe Pro Glu 
    1040                 1045                 1050             


Phe Ala  Arg Tyr Thr Thr Pro  Glu Asp Ala Thr Pro  Glu Pro Gly 
    1055                 1060                 1065             


Glu Asp  Pro Arg Val Thr Arg  Ala Lys Tyr Phe Ile  Arg Asp Glu 
    1070                 1075                 1080             


Phe Leu  Arg Ile Ser Thr Ala  Ser Gly Asp Gly Arg  His Tyr Cys 
    1085                 1090                 1095             


Tyr Pro  His Phe Thr Cys Ala  Val Asp Thr Glu Asn  Ile Arg Arg 
    1100                 1105                 1110             


Val Phe  Asn Asp Cys Arg Asp  Ile Ile Gln Arg Met  His Leu Arg 
    1115                 1120                 1125             


Gln Tyr  Glu Leu Leu 
    1130             


<210>  13
<211>  3585
<212>  DNA
<213>  Artificial

<220>
<223>  GLP1R-G-L (RGL) fusion protein encoding DNA

<400>  13
atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg       60

gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga      120

gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg      180

ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc      240

gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg      300

taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg      360

agggacttgt cggagtgcga ggagtccaag cgaggggaga gaagctcccc ggaggagcag      420

ctcctgttcc tctacatcat ctacacggtg ggctacgcac tctccttctc tgctctggtt      480

atcgcctctg cgatcctcct cggcttcaga cacctgcact gcaccaggaa ctacatccac      540

ctgaacctgt ttgcatcctt catcctgcga gcattgtccg tcttcatcaa ggacgcagcc      600

ctgaagtgga tgtatagcac agccgcccag cagcaccagt gggatgggct cctctcctac      660

caggactctc tgagctgccg cctggtgttt ctgctcatgc agtactgtgt ggcggccaat      720

tactactggc tcttggtgga gggcgtgtac ctgtacacac tgctggcctt ctcggtctta      780

tctgagcaat ggatcttcag gctctacgtg agcataggct ggggtgttcc cctgctgttt      840

gttgtcccct ggggcattgt caagtacctc tatgaggacg agggctgctg gaccaggaac      900

tccaacatga actactggct cattatccgg ctgcccattc tctttgccat tggggtgaac      960

ttcctcatct ttgttcgggt catctgcatc gtggtatcca aactgaaggc caatctcatg     1020

tgcaagacag acatcaaatg cagacttgcc aagtccacgc tgacactcat ccccctgctg     1080

gggactcatg aggtcatctt tgcctttgtg atggacgagc acgcccgggg gaccctgcgc     1140

ttcatcaagc tgtttacaga gctctccttc acctccttcc aggggctgat ggtggccata     1200

ttatactgct ttgtcaacaa tgaggtccag ctggaatttc ggaagagctg ggagcgctgg     1260

cggcttgagc acttgcacat ccagagggac agcagcatga agcccctcaa gtgtcccacc     1320

agcagcctga gcagtggagc cacggcgggc agcagcatgt acacagccac ttgccaggcc     1380

tcctgcagcc acccaacttt tctatacaaa gttgccatgg gctgcctcgg gaacagtaag     1440

accgaggacc agcgcaacga ggagaaggcg cagcgtgagg ccaacaaaaa gatcgagaag     1500

cagctgcaga aggacaagca ggtctaccgg gccacgcacc gcctgctgct gctgggtgct     1560

ggagaatctg gtaaaagcac cattgtgaag cagatgagga tcctgcatgt taatgggttt     1620

aatggagagg gcggcgaaga ggacccgcag gctgcaagga gcaacagcga tggtgagaag     1680

gcaaccaaag tgcaggacat caaaaacaac ctgaaagagg cgattgaaac cattgtggcc     1740

gccatgagca acctggtgcc ccccgtggag ctggccaacc ccgagaacca gttcagagtg     1800

gactacattc tgagtgtgat gaacgtgcct gactttgact tccctcccga attctatgag     1860

catgccaagg ctctgtggga ggatgaagga gtgcgtgcct gctacgaacg ctccaacgag     1920

taccagctga ttgactgtgc ccagtacttc ctggacaaga tcgacgtgat caagcaggct     1980

gactatgtgc cgagcgatca ggacctgctt cgctgccgtg tcctgacttc tggaatcttt     2040

gagaccaagt tccaggtgga caaagtcaac ttccacatgt ttgacgtggg tggccagcgc     2100

gatgaacgcc gcaagtggat ccagtgcttc aacgatgtga ctgccatcat cttcgtggtg     2160

gccagcagca gctacaacat ggtcatccgg gaggacaacc agaccaaccg cctgcaggag     2220

gctctgaacc tcttcaagag catctggaac aacagatggc tgcgcaccat ctctgtgatc     2280

ctgttcctca acaagcaaga tctgctcgct gagaaagtcc ttgctgggaa atcgaagatt     2340

gaggactact ttccagaatt tgctcgctac actactcctg aggatgctac tcccgagccc     2400

ggagaggacc cacgcgtgac ccgggccaag tacttcattc gagatgagtt tctgaggatc     2460

agcactgcca gtggagatgg gcgtcactac tgctaccctc atttcacctg cgctgtggac     2520

actgagaaca tccgccgtgt gttcaacgac tgccgtgaca tcattcagcg catgcacctt     2580

cgtcagtacg agctgctcac aactttgtat aataaagttg ccatgaccag caaggtgtac     2640

gaccccgagc agaggaagag gatgatcacc ggcccccagt ggtgggccag gtgcaagcag     2700

atgaacgtgc tggacagctt catcaactac tacgacagcg agaagcacgc cgagaacgcc     2760

gtgatcttcc tgcacggcaa cgccaccagc agctacctgt ggaggcacgt ggtgccccac     2820

atcgagcccg tggccaggtg catcatcccc gatctgatcg gcatgggcaa gagcggcaag     2880

agcggcaacg gcagctacag gctgctggac cactacaagt acctgaccgc ctggttcgag     2940

ctcctgaacc tgcccaagaa gatcatcttc gtgggccacg actggggagc tgcactggcc     3000

ttccactacg cctacgagca ccaggacaga atcaaggcca tcgtgcacat ggagagcgtg     3060

gtggacgtga tcgagagctg ggacgagtgg ccagacatcg aggaggacat cgccctgatc     3120

aagagcgagg agggcgagaa gatggtgctg gagaacaact tcttcgtgga gaccgtcctg     3180

cccagcaaga tcatgagaaa gctggagccc gaggagttcg ccgcctacct ggagcccttc     3240

aaggagaagg gcgaggtgag aagacccacc ctgagctggc ccagagagat ccccctggtg     3300

aagggcggca agcccgacgt ggtgcagatc gtgagaaact acaacgccta cctgagagcc     3360

agcgacgacc tgcccaagct gttcatcgag agcgaccccg gcttcttcag caacgccatc     3420

gtggagggcg ccaagaagtt ccccaacacc gagttcgtga aggtgaaggg cctgcacttt     3480

ctccaggaag acgcccccga cgagatgggc aagtacatca agagcttcgt ggagagagtg     3540

ctgaagaacg agcaagccga ctacaaggac gacgatgaca agtaa                     3585


<210>  14
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  GLP1R-G-L (RGL) fusion protein

<400>  14

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser His 
    450                 455                 460                 


Pro Thr Phe Leu Tyr Lys Val Ala Met Gly Cys Leu Gly Asn Ser Lys 
465                 470                 475                 480 


Thr Glu Asp Gln Arg Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys 
                485                 490                 495     


Lys Ile Glu Lys Gln Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr 
            500                 505                 510         


His Arg Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
        515                 520                 525             


Val Lys Gln Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly 
    530                 535                 540                 


Gly Glu Glu Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys 
545                 550                 555                 560 


Ala Thr Lys Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu 
                565                 570                 575     


Thr Ile Val Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala 
            580                 585                 590         


Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn 
        595                 600                 605             


Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala 
    610                 615                 620                 


Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu 
625                 630                 635                 640 


Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val 
                645                 650                 655     


Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys 
            660                 665                 670         


Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys 
        675                 680                 685             


Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg 
    690                 695                 700                 


Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile Ile Phe Val Val 
705                 710                 715                 720 


Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp Asn Gln Thr Asn 
                725                 730                 735     


Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg 
            740                 745                 750         


Trp Leu Arg Thr Ile Ser Val Ile Leu Phe Leu Asn Lys Gln Asp Leu 
        755                 760                 765             


Leu Ala Glu Lys Val Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe 
    770                 775                 780                 


Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro 
785                 790                 795                 800 


Gly Glu Asp Pro Arg Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu 
                805                 810                 815     


Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr 
            820                 825                 830         


Pro His Phe Thr Cys Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe 
        835                 840                 845             


Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His Leu Arg Gln Tyr Glu 
    850                 855                 860                 


Leu Leu Thr Thr Leu Tyr Asn Lys Val Ala Met Thr Ser Lys Val Tyr 
865                 870                 875                 880 


Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala 
                885                 890                 895     


Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp 
            900                 905                 910         


Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala 
        915                 920                 925             


Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro Val 
    930                 935                 940                 


Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys 
945                 950                 955                 960 


Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr 
                965                 970                 975     


Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly 
            980                 985                 990         


His Asp Trp Gly Ala Ala Leu Ala  Phe His Tyr Ala Tyr  Glu His Gln 
        995                 1000                 1005             


Asp Arg  Ile Lys Ala Ile Val  His Met Glu Ser Val  Val Asp Val 
    1010                 1015                 1020             


Ile Glu  Ser Trp Asp Glu Trp  Pro Asp Ile Glu Glu  Asp Ile Ala 
    1025                 1030                 1035             


Leu Ile  Lys Ser Glu Glu Gly  Glu Lys Met Val Leu  Glu Asn Asn 
    1040                 1045                 1050             


Phe Phe  Val Glu Thr Val Leu  Pro Ser Lys Ile Met  Arg Lys Leu 
    1055                 1060                 1065             


Glu Pro  Glu Glu Phe Ala Ala  Tyr Leu Glu Pro Phe  Lys Glu Lys 
    1070                 1075                 1080             


Gly Glu  Val Arg Arg Pro Thr  Leu Ser Trp Pro Arg  Glu Ile Pro 
    1085                 1090                 1095             


Leu Val  Lys Gly Gly Lys Pro  Asp Val Val Gln Ile  Val Arg Asn 
    1100                 1105                 1110             


Tyr Asn  Ala Tyr Leu Arg Ala  Ser Asp Asp Leu Pro  Lys Leu Phe 
    1115                 1120                 1125             


Ile Glu  Ser Asp Pro Gly Phe  Phe Ser Asn Ala Ile  Val Glu Gly 
    1130                 1135                 1140             


Ala Lys  Lys Phe Pro Asn Thr  Glu Phe Val Lys Val  Lys Gly Leu 
    1145                 1150                 1155             


His Phe  Leu Gln Glu Asp Ala  Pro Asp Glu Met Gly  Lys Tyr Ile 
    1160                 1165                 1170             


Lys Ser  Phe Val Glu Arg Val  Leu Lys Asn Glu Gln  Ala Asp Tyr 
    1175                 1180                 1185             


Lys Asp  Asp Asp Asp Lys 
    1190                 


<210>  15
<211>  3594
<212>  DNA
<213>  Artificial

<220>
<223>  GIPR-G-L (RGL) fusion protein encoding DNA

<400>  15
atgactacct ctccgatcct gcagctgctg ctgcggctct cactgtgcgg gctgctgctc       60

cagagggcgg agacaggctc taaggggcag acggcggggg agctgtacca gcgctgggaa      120

cggtaccgca gggagtgcca ggagaccttg gcagccgcgg aaccgccttc aggcctcgcc      180

tgtaacgggt ccttcgatat gtacgtctgc tgggactatg ctgcacccaa tgccactgcc      240

cgtgcgtcct gcccctggta cctgccctgg caccaccatg tggctgcagg tttcgtcctc      300

cgccagtgtg gtagtgatgg ccaatgggga ctttggagag accatacaca atgtgagaac      360

ccagagaaga atgaggcctt tctggaccaa aggctcatct tggagcggtt gcaggtcatg      420

tacactgtcg gctactccct gtctctcgcc acactgctgc tagccctgct catcttgagt      480

ttgttcaggc ggctacattg cactagaaac tatatccaca tcaacctgtt cacgtctttc      540

atgctgcgag ctgcggccat tctcagccga gaccgtctgc tacctcgacc tggcccctac      600

cttggggacc aggcccttgc gctgtggaac caggccctcg ctgcctgccg cacggcccag      660

atcgtgaccc agtactgcgt gggtgccaac tacacgtggc tgctggtgga gggcgtctac      720

ctgcacagtc tcctggtgct cgtgggaggc tccgaggagg gccacttccg ctactacctg      780

ctcctcggct ggggggcccc cgcgcttttc gtcattccct gggtgatcgt caggtacctg      840

tacgagaaca cgcagtgctg ggagcgcaac gaagtcaagg ccatttggtg gattatacgg      900

acccccatcc tcatgaccat cttgattaat ttcctcattt ttatccgcat tcttggcatt      960

ctcctgtcca agctgaggac acggcaaatg cgctgccggg attaccggct gaggctggct     1020

cgctccacgc tgacgctggt gcccctgctg ggtgtccacg aggtggtgtt tgctcccgtg     1080

acagaggaac aggcccgggg cgccctgcgc ttcgccaagc tcggctttga gatcttcctc     1140

agctccttcc agggcttcct ggtcagcgtc ctctactgct tcatcaacaa ggaggtgcag     1200

tcggagatcc gccgtggctg gcaccactgc cgcctgcgcc gcagcctggg cgaggagcaa     1260

cgccagctcc cggagcgcgc cttccgggcc ctgccctccg gctccggccc gggcgaggtc     1320

cccaccagcc gcggcttgtc ctcggggacc ctcccagggc ctgggaatga ggccagccgg     1380

gagttggaaa gttactgcca cccaactttt ctatacaaag ttgccatggg ctgcctcggg     1440

aacagtaaga ccgaggacca gcgcaacgag gagaaggcgc agcgtgaggc caacaaaaag     1500

atcgagaagc agctgcagaa ggacaagcag gtctaccggg ccacgcaccg cctgctgctg     1560

ctgggtgctg gagaatctgg taaaagcacc attgtgaagc agatgaggat cctgcatgtt     1620

aatgggttta atggagaggg cggcgaagag gacccgcagg ctgcaaggag caacagcgat     1680

ggtgagaagg caaccaaagt gcaggacatc aaaaacaacc tgaaagaggc gattgaaacc     1740

attgtggccg ccatgagcaa cctggtgccc cccgtggagc tggccaaccc cgagaaccag     1800

ttcagagtgg actacattct gagtgtgatg aacgtgcctg actttgactt ccctcccgaa     1860

ttctatgagc atgccaaggc tctgtgggag gatgaaggag tgcgtgcctg ctacgaacgc     1920

tccaacgagt accagctgat tgactgtgcc cagtacttcc tggacaagat cgacgtgatc     1980

aagcaggctg actatgtgcc gagcgatcag gacctgcttc gctgccgtgt cctgacttct     2040

ggaatctttg agaccaagtt ccaggtggac aaagtcaact tccacatgtt tgacgtgggt     2100

ggccagcgcg atgaacgccg caagtggatc cagtgcttca acgatgtgac tgccatcatc     2160

ttcgtggtgg ccagcagcag ctacaacatg gtcatccggg aggacaacca gaccaaccgc     2220

ctgcaggagg ctctgaacct cttcaagagc atctggaaca acagatggct gcgcaccatc     2280

tctgtgatcc tgttcctcaa caagcaagat ctgctcgctg agaaagtcct tgctgggaaa     2340

tcgaagattg aggactactt tccagaattt gctcgctaca ctactcctga ggatgctact     2400

cccgagcccg gagaggaccc acgcgtgacc cgggccaagt acttcattcg agatgagttt     2460

ctgaggatca gcactgccag tggagatggg cgtcactact gctaccctca tttcacctgc     2520

gctgtggaca ctgagaacat ccgccgtgtg ttcaacgact gccgtgacat cattcagcgc     2580

atgcaccttc gtcagtacga gctgctcaca actttgtata ataaagttgc catgaccagc     2640

aaggtgtacg accccgagca gaggaagagg atgatcaccg gcccccagtg gtgggccagg     2700

tgcaagcaga tgaacgtgct ggacagcttc atcaactact acgacagcga gaagcacgcc     2760

gagaacgccg tgatcttcct gcacggcaac gccaccagca gctacctgtg gaggcacgtg     2820

gtgccccaca tcgagcccgt ggccaggtgc atcatccccg atctgatcgg catgggcaag     2880

agcggcaaga gcggcaacgg cagctacagg ctgctggacc actacaagta cctgaccgcc     2940

tggttcgagc tcctgaacct gcccaagaag atcatcttcg tgggccacga ctggggagct     3000

gcactggcct tccactacgc ctacgagcac caggacagaa tcaaggccat cgtgcacatg     3060

gagagcgtgg tggacgtgat cgagagctgg gacgagtggc cagacatcga ggaggacatc     3120

gccctgatca agagcgagga gggcgagaag atggtgctgg agaacaactt cttcgtggag     3180

accgtcctgc ccagcaagat catgagaaag ctggagcccg aggagttcgc cgcctacctg     3240

gagcccttca aggagaaggg cgaggtgaga agacccaccc tgagctggcc cagagagatc     3300

cccctggtga agggcggcaa gcccgacgtg gtgcagatcg tgagaaacta caacgcctac     3360

ctgagagcca gcgacgacct gcccaagctg ttcatcgaga gcgaccccgg cttcttcagc     3420

aacgccatcg tggagggcgc caagaagttc cccaacaccg agttcgtgaa ggtgaagggc     3480

ctgcactttc tccaggaaga cgcccccgac gagatgggca agtacatcaa gagcttcgtg     3540

gagagagtgc tgaagaacga gcaagccgac tacaaggacg acgatgacaa gtaa           3594


<210>  16
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  GIPR-G-L (RGL) fusion protein

<400>  16

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys His Pro Thr Phe Leu Tyr Lys Val Ala Met Gly Cys Leu Gly 
465                 470                 475                 480 


Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu Lys Ala Gln Arg Glu 
                485                 490                 495     


Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys Asp Lys Gln Val Tyr 
            500                 505                 510         


Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys 
        515                 520                 525             


Ser Thr Ile Val Lys Gln Met Arg Ile Leu His Val Asn Gly Phe Asn 
    530                 535                 540                 


Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp 
545                 550                 555                 560 


Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys Asn Asn Leu Lys Glu 
                565                 570                 575     


Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn Leu Val Pro Pro Val 
            580                 585                 590         


Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser 
        595                 600                 605             


Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu His 
    610                 615                 620                 


Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg 
625                 630                 635                 640 


Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys 
                645                 650                 655     


Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu 
            660                 665                 670         


Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln 
        675                 680                 685             


Val Asp Lys Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg Asp 
    690                 695                 700                 


Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile Ile 
705                 710                 715                 720 


Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp Asn 
                725                 730                 735     


Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys Ser Ile Trp 
            740                 745                 750         


Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile Leu Phe Leu Asn Lys 
        755                 760                 765             


Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly Lys Ser Lys Ile Glu 
    770                 775                 780                 


Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu Asp Ala Thr 
785                 790                 795                 800 


Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg Ala Lys Tyr Phe Ile 
                805                 810                 815     


Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp Gly Arg His 
            820                 825                 830         


Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp Thr Glu Asn Ile Arg 
        835                 840                 845             


Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His Leu Arg 
    850                 855                 860                 


Gln Tyr Glu Leu Leu Thr Thr Leu Tyr Asn Lys Val Ala Met Thr Ser 
865                 870                 875                 880 


Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln 
                885                 890                 895     


Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn 
            900                 905                 910         


Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His 
        915                 920                 925             


Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile 
    930                 935                 940                 


Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys 
945                 950                 955                 960 


Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys 
                965                 970                 975     


Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile 
            980                 985                 990         


Phe Val Gly His Asp Trp Gly Ala  Ala Leu Ala Phe His  Tyr Ala Tyr 
        995                 1000                 1005             


Glu His  Gln Asp Arg Ile Lys  Ala Ile Val His Met  Glu Ser Val 
    1010                 1015                 1020             


Val Asp  Val Ile Glu Ser Trp  Asp Glu Trp Pro Asp  Ile Glu Glu 
    1025                 1030                 1035             


Asp Ile  Ala Leu Ile Lys Ser  Glu Glu Gly Glu Lys  Met Val Leu 
    1040                 1045                 1050             


Glu Asn  Asn Phe Phe Val Glu  Thr Val Leu Pro Ser  Lys Ile Met 
    1055                 1060                 1065             


Arg Lys  Leu Glu Pro Glu Glu  Phe Ala Ala Tyr Leu  Glu Pro Phe 
    1070                 1075                 1080             


Lys Glu  Lys Gly Glu Val Arg  Arg Pro Thr Leu Ser  Trp Pro Arg 
    1085                 1090                 1095             


Glu Ile  Pro Leu Val Lys Gly  Gly Lys Pro Asp Val  Val Gln Ile 
    1100                 1105                 1110             


Val Arg  Asn Tyr Asn Ala Tyr  Leu Arg Ala Ser Asp  Asp Leu Pro 
    1115                 1120                 1125             


Lys Leu  Phe Ile Glu Ser Asp  Pro Gly Phe Phe Ser  Asn Ala Ile 
    1130                 1135                 1140             


Val Glu  Gly Ala Lys Lys Phe  Pro Asn Thr Glu Phe  Val Lys Val 
    1145                 1150                 1155             


Lys Gly  Leu His Phe Leu Gln  Glu Asp Ala Pro Asp  Glu Met Gly 
    1160                 1165                 1170             


Lys Tyr  Ile Lys Ser Phe Val  Glu Arg Val Leu Lys  Asn Glu Gln 
    1175                 1180                 1185             


Ala Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1190                 1195         


<210>  17
<211>  6864
<212>  DNA
<213>  Artificial

<220>
<223>  A2AR-G-L (RGL) fusion protein encoding DNA

<400>  17
atgcccatca tgggctcctc ggtgtacatc acggtggagc tggccattgc tgtgctggcc       60

atcctgggca atgtgctggt gtgctgggcc gtgtggctca acagcaacct gcagaacgtc      120

accaactact ttgtggtgtc actggcggcg gccgacatcg cagtgggtgt gctcgccatc      180

ccctttgcca tcaccatcag caccgggttc tgcgctgcct gccacggctg cctcttcatt      240

gcctgcttcg tcctggtcct cacgcagagc tccatcttca gtctcctggc catcgccatt      300

gaccgctaca ttgccatccg catcccgctc cggtacaatg gcttggtgac cggcacgagg      360

gctaagggca tcattgccat ctgctgggtg ctgtcgtttg ccatcggcct gactcccatg      420

ctaggttgga acaactgcgg tcagccaaag gagggcaaga accactccca gggctgcggg      480

gagggccaag tggcctgtct ctttgaggat gtggtcccca tgaactacat ggtgtacttc      540

aacttctttg cctgtgtgct ggtgcccctg ctgctcatgc tgggtgtcta tttgcggatc      600

ttcctggcgg cgcgacgaca gctgaagcag atggagagcc agcctctgcc gggggagcgg      660

gcacggtcca cactgcagaa ggaggtccat gctgccaagt cactggccat cattgtgggg      720

ctctttgccc tctgctggct gcccctacac atcatcaact gcttcacttt cttctgcccc      780

gactgcagcc acgcccctct ctggctcatg tacctggcca tcgtcctctc ccacaccaat      840

tcggttgtga atcccttcat ctacgcctac cgtatccgcg agttccgcca gaccttccgc      900

aagatcattc gcagccacgt cctgaggcag caagaacctt tcaaggcagc tggcaccagt      960

gcccgggtct tggcagctca tggcagtgac ggagagcagg tcagcctccg tctcaacggc     1020

cacccgccag gagtgtgggc caacggcagt gctccccacc ctgagcggag gcccaatggc     1080

tatgccctgg ggctggtgag tggagggagt gcccaagagt cccaggggaa cacgggcctc     1140

ccagacgtgg agctccttag ccatgagctc aagggagtgt gcccagagcc ccctggccta     1200

gatgaccccc tggcccagga tggagcagga gtgtcccacc caacttttct atacaaagtt     1260

gccatgggct gcctcgggaa cagtaagacc gaggaccagc gcaacgagga gaaggcgcag     1320

cgtgaggcca acaaaaagat cgagaagcag ctgcagaagg acaagcaggt ctaccgggcc     1380

acgcaccgcc tgctgctgct gggtgctgga gaatctggta aaagcaccat tgtgaagcag     1440

atgaggatcc tgcatgttaa tgggtttaat ggagagggcg gcgaagagga cccgcaggct     1500

gcaaggagca acagcgatgg tgagaaggca accaaagtgc aggacatcaa aaacaacctg     1560

aaagaggcga ttgaaaccat tgtggccgcc atgagcaacc tggtgccccc cgtggagctg     1620

gccaaccccg agaaccagtt cagagtggac tacatcctga gtgtgatgaa cgtgcctgac     1680

tttgacttcc ctcccgaatt ctatgagcat gccaaggctc tgtgggagga tgaaggagtg     1740

cgtgcctgct acgaacgctc caacgagtac cagctgattg actgtgccca gtacttcctg     1800

gacaagatcg acgtgatcaa gcaggctgac tatgtgccga gcgatcagga cctgcttcgc     1860

tgccgtgtcc tgacttctgg aatctttgag accaagttcc aggtggacaa agtcaacttc     1920

cacatgtttg acgtgggtgg ccagcgcgat gaacgccgca agtggatcca gtgcttcaac     1980

gatgtgactg ccatcatctt cgtggtggcc agcagcagct acaacatggt catccgggag     2040

gacaaccaga ccaaccgcct gcaggaggct ctgaacctct tcaagagcat ctggaacaac     2100

agatggctgc gcaccatctc tgtgatcctg ttcctcaaca agcaagatct gctcgctgag     2160

aaagtccttg ctgggaaatc gaagattgag gactactttc cagaatttgc tcgctacact     2220

actcctgagg atgctactcc cgagcccgga gaggacccac gcgtgacccg ggccaagtac     2280

ttcattcgag atgagtttct gaggatcagc actgccagtg gagatgggcg tcactactgc     2340

taccctcatt tcacctgcgc tgtggacact gagaacatcc gccgtgtgtt caacgactgc     2400

cgtgacatca ttcagcgcat gcaccttcgt cagtacgagc tgctcacaac tttgtataat     2460

aaagttgcca tgaccagcaa ggtgtacgac cccgagcaga ggaagaggat gatcaccggc     2520

ccccagtggt gggccaggtg caagcagatg aacgtgctgg acagcttcat caactactac     2580

gacagcgaga agcacgccga gaacgccgtg atcttcctgc acggcaacgc caccagcagc     2640

tacctgtgga ggcacgtggt gccccacatc gagcccgtgg ccaggtgcat catccccgat     2700

ctgatcggca tgggcaagag cggcaagagc ggcaacggca gctacaggct gctggaccac     2760

tacaagtacc tgaccgcctg gttcgagctc ctgaacctgc ccaagaagat catcttcgtg     2820

ggccacgact ggggagctgc actggccttc cactacgcct acgagcacca ggacagaatc     2880

aaggccatcg tgcacatgga gagcgtggtg gacgtgatcg agagctggga cgagtggcca     2940

gacatcgagg aggacatcgc cctgatcaag agcgaggagg gcgagaagat ggtgctggag     3000

aacaacttct tcgtggagac cgtcctgccc agcaagatca tgagaaagct ggagcccgag     3060

gagttcgccg cctacctgga gcccttcaag gagaagggcg aggtgagaag acccaccctg     3120

agctggccca gagagatccc cctggtgaag ggcggcaagc ccgacgtggt gcagatcgtg     3180

agaaactaca acgcctacct gagagccagc gacgacctgc ccaagctgtt catcgagagc     3240

gaccccggct tcttcagcaa cgccatcgtg gagggcgcca agaagttccc caacaccgag     3300

ttcgtgaagg tgaagggcct gcactttctc caggaagacg cccccgacga gatgggcaag     3360

tacatcaaga gcttcgtgga gagagtgctg aagaacgagc aagccgacta caaggatgac     3420

gatgacaagt aaatgcccat catgggctcc tcggtgtaca tcacggtgga gctggccatt     3480

gctgtgctgg ccatcctggg caatgtgctg gtgtgctggg ccgtgtggct caacagcaac     3540

ctgcagaacg tcaccaacta ctttgtggtg tcactggcgg cggccgacat cgcagtgggt     3600

gtgctcgcca tcccctttgc catcaccatc agcaccgggt tctgcgctgc ctgccacggc     3660

tgcctcttca ttgcctgctt cgtcctggtc ctcacgcaga gctccatctt cagtctcctg     3720

gccatcgcca ttgaccgcta cattgccatc cgcatcccgc tccggtacaa tggcttggtg     3780

accggcacga gggctaaggg catcattgcc atctgctggg tgctgtcgtt tgccatcggc     3840

ctgactccca tgctaggttg gaacaactgc ggtcagccaa aggagggcaa gaaccactcc     3900

cagggctgcg gggagggcca agtggcctgt ctctttgagg atgtggtccc catgaactac     3960

atggtgtact tcaacttctt tgcctgtgtg ctggtgcccc tgctgctcat gctgggtgtc     4020

tatttgcgga tcttcctggc ggcgcgacga cagctgaagc agatggagag ccagcctctg     4080

ccgggggagc gggcacggtc cacactgcag aaggaggtcc atgctgccaa gtcactggcc     4140

atcattgtgg ggctctttgc cctctgctgg ctgcccctac acatcatcaa ctgcttcact     4200

ttcttctgcc ccgactgcag ccacgcccct ctctggctca tgtacctggc catcgtcctc     4260

tcccacacca attcggttgt gaatcccttc atctacgcct accgtatccg cgagttccgc     4320

cagaccttcc gcaagatcat tcgcagccac gtcctgaggc agcaagaacc tttcaaggca     4380

gctggcacca gtgcccgggt cttggcagct catggcagtg acggagagca ggtcagcctc     4440

cgtctcaacg gccacccgcc aggagtgtgg gccaacggca gtgctcccca ccctgagcgg     4500

aggcccaatg gctatgccct ggggctggtg agtggaggga gtgcccaaga gtcccagggg     4560

aacacgggcc tcccagacgt ggagctcctt agccatgagc tcaagggagt gtgcccagag     4620

ccccctggcc tagatgaccc cctggcccag gatggagcag gagtgtccca cccaactttt     4680

ctatacaaag ttgccatggg ctgcctcggg aacagtaaga ccgaggacca gcgcaacgag     4740

gagaaggcgc agcgtgaggc caacaaaaag atcgagaagc agctgcagaa ggacaagcag     4800

gtctaccggg ccacgcaccg cctgctgctg ctgggtgctg gagaatctgg taaaagcacc     4860

attgtgaagc agatgaggat cctgcatgtt aatgggttta atggagaggg cggcgaagag     4920

gacccgcagg ctgcaaggag caacagcgat ggtgagaagg caaccaaagt gcaggacatc     4980

aaaaacaacc tgaaagaggc gattgaaacc attgtggccg ccatgagcaa cctggtgccc     5040

cccgtggagc tggccaaccc cgagaaccag ttcagagtgg actacatcct gagtgtgatg     5100

aacgtgcctg actttgactt ccctcccgaa ttctatgagc atgccaaggc tctgtgggag     5160

gatgaaggag tgcgtgcctg ctacgaacgc tccaacgagt accagctgat tgactgtgcc     5220

cagtacttcc tggacaagat cgacgtgatc aagcaggctg actatgtgcc gagcgatcag     5280

gacctgcttc gctgccgtgt cctgacttct ggaatctttg agaccaagtt ccaggtggac     5340

aaagtcaact tccacatgtt tgacgtgggt ggccagcgcg atgaacgccg caagtggatc     5400

cagtgcttca acgatgtgac tgccatcatc ttcgtggtgg ccagcagcag ctacaacatg     5460

gtcatccggg aggacaacca gaccaaccgc ctgcaggagg ctctgaacct cttcaagagc     5520

atctggaaca acagatggct gcgcaccatc tctgtgatcc tgttcctcaa caagcaagat     5580

ctgctcgctg agaaagtcct tgctgggaaa tcgaagattg aggactactt tccagaattt     5640

gctcgctaca ctactcctga ggatgctact cccgagcccg gagaggaccc acgcgtgacc     5700

cgggccaagt acttcattcg agatgagttt ctgaggatca gcactgccag tggagatggg     5760

cgtcactact gctaccctca tttcacctgc gctgtggaca ctgagaacat ccgccgtgtg     5820

ttcaacgact gccgtgacat cattcagcgc atgcaccttc gtcagtacga gctgctcaca     5880

actttgtata ataaagttgc catgaccagc aaggtgtacg accccgagca gaggaagagg     5940

atgatcaccg gcccccagtg gtgggccagg tgcaagcaga tgaacgtgct ggacagcttc     6000

atcaactact acgacagcga gaagcacgcc gagaacgccg tgatcttcct gcacggcaac     6060

gccaccagca gctacctgtg gaggcacgtg gtgccccaca tcgagcccgt ggccaggtgc     6120

atcatccccg atctgatcgg catgggcaag agcggcaaga gcggcaacgg cagctacagg     6180

ctgctggacc actacaagta cctgaccgcc tggttcgagc tcctgaacct gcccaagaag     6240

atcatcttcg tgggccacga ctggggagct gcactggcct tccactacgc ctacgagcac     6300

caggacagaa tcaaggccat cgtgcacatg gagagcgtgg tggacgtgat cgagagctgg     6360

gacgagtggc cagacatcga ggaggacatc gccctgatca agagcgagga gggcgagaag     6420

atggtgctgg agaacaactt cttcgtggag accgtcctgc ccagcaagat catgagaaag     6480

ctggagcccg aggagttcgc cgcctacctg gagcccttca aggagaaggg cgaggtgaga     6540

agacccaccc tgagctggcc cagagagatc cccctggtga agggcggcaa gcccgacgtg     6600

gtgcagatcg tgagaaacta caacgcctac ctgagagcca gcgacgacct gcccaagctg     6660

ttcatcgaga gcgaccccgg cttcttcagc aacgccatcg tggagggcgc caagaagttc     6720

cccaacaccg agttcgtgaa ggtgaagggc ctgcactttc tccaggaaga cgcccccgac     6780

gagatgggca agtacatcaa gagcttcgtg gagagagtgc tgaagaacga gcaagccgac     6840

tacaaggatg acgatgacaa gtaa                                            6864


<210>  18
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  A2AR-G-L (RGL) fusion protein

<400>  18

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Thr Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser His Pro Thr Phe 
                405                 410                 415     


Leu Tyr Lys Val Ala Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp 
            420                 425                 430         


Gln Arg Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu 
        435                 440                 445             


Lys Gln Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu 
    450                 455                 460                 


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
465                 470                 475                 480 


Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu 
                485                 490                 495     


Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys 
            500                 505                 510         


Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val 
        515                 520                 525             


Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu 
    530                 535                 540                 


Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp 
545                 550                 555                 560 


Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu 
                565                 570                 575     


Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu 
            580                 585                 590         


Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln 
        595                 600                 605             


Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu 
    610                 615                 620                 


Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe 
625                 630                 635                 640 


His Met Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile 
                645                 650                 655     


Gln Cys Phe Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser 
            660                 665                 670         


Ser Tyr Asn Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln 
        675                 680                 685             


Glu Ala Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg 
    690                 695                 700                 


Thr Ile Ser Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu 
705                 710                 715                 720 


Lys Val Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe 
                725                 730                 735     


Ala Arg Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp 
            740                 745                 750         


Pro Arg Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg 
        755                 760                 765             


Ile Ser Thr Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe 
    770                 775                 780                 


Thr Cys Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys 
785                 790                 795                 800 


Arg Asp Ile Ile Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu Thr 
                805                 810                 815     


Thr Leu Tyr Asn Lys Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu 
            820                 825                 830         


Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys 
        835                 840                 845             


Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys 
    850                 855                 860                 


His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser 
865                 870                 875                 880 


Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro Val Ala Arg Cys 
                885                 890                 895     


Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn 
            900                 905                 910         


Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe 
        915                 920                 925             


Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp 
    930                 935                 940                 


Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile 
945                 950                 955                 960 


Lys Ala Ile Val His Met Glu Ser Val Val Asp Val Ile Glu Ser Trp 
                965                 970                 975     


Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu 
            980                 985                 990         


Glu Gly Glu Lys Met Val Leu Glu  Asn Asn Phe Phe Val  Glu Thr Val 
        995                 1000                 1005             


Leu Pro  Ser Lys Ile Met Arg  Lys Leu Glu Pro Glu  Glu Phe Ala 
    1010                 1015                 1020             


Ala Tyr  Leu Glu Pro Phe Lys  Glu Lys Gly Glu Val  Arg Arg Pro 
    1025                 1030                 1035             


Thr Leu  Ser Trp Pro Arg Glu  Ile Pro Leu Val Lys  Gly Gly Lys 
    1040                 1045                 1050             


Pro Asp  Val Val Gln Ile Val  Arg Asn Tyr Asn Ala  Tyr Leu Arg 
    1055                 1060                 1065             


Ala Ser  Asp Asp Leu Pro Lys  Leu Phe Ile Glu Ser  Asp Pro Gly 
    1070                 1075                 1080             


Phe Phe  Ser Asn Ala Ile Val  Glu Gly Ala Lys Lys  Phe Pro Asn 
    1085                 1090                 1095             


Thr Glu  Phe Val Lys Val Lys  Gly Leu His Phe Leu  Gln Glu Asp 
    1100                 1105                 1110             


Ala Pro  Asp Glu Met Gly Lys  Tyr Ile Lys Ser Phe  Val Glu Arg 
    1115                 1120                 1125             


Val Leu  Lys Asn Glu Gln Ala  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1130                 1135                 1140             


<210>  19
<211>  3528
<212>  DNA
<213>  Artificial

<220>
<223>  GLP1R-G(1-71)-L-G(82-394) (RGLG-1) fusion protein encoding DNA

<400>  19
atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg       60

gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga      120

gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg      180

ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc      240

gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg      300

taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg      360

agggacttgt cggagtgcga ggagtccaag cgaggggaga gaagctcccc ggaggagcag      420

ctcctgttcc tctacatcat ctacacggtg ggctacgcac tctccttctc tgctctggtt      480

atcgcctctg cgatcctcct cggcttcaga cacctgcact gcaccaggaa ctacatccac      540

ctgaacctgt ttgcatcctt catcctgcga gcattgtccg tcttcatcaa ggacgcagcc      600

ctgaagtgga tgtatagcac agccgcccag cagcaccagt gggatgggct cctctcctac      660

caggactctc tgagctgccg cctggtgttt ctgctcatgc agtactgtgt ggcggccaat      720

tactactggc tcttggtgga gggcgtgtac ctgtacacac tgctggcctt ctcggtctta      780

tctgagcaat ggatcttcag gctctacgtg agcataggct ggggtgttcc cctgctgttt      840

gttgtcccct ggggcattgt caagtacctc tatgaggacg agggctgctg gaccaggaac      900

tccaacatga actactggct cattatccgg ctgcccattc tctttgccat tggggtgaac      960

ttcctcatct ttgttcgggt catctgcatc gtggtatcca aactgaaggc caatctcatg     1020

tgcaagacag acatcaaatg cagacttgcc aagtccacgc tgacactcat ccccctgctg     1080

gggactcatg aggtcatctt tgcctttgtg atggacgagc acgcccgggg gaccctgcgc     1140

ttcatcaagc tgtttacaga gctctccttc acctccttcc aggggctgat ggtggccata     1200

ttatactgct ttgtcaacaa tgaggtccag ctggaatttc ggaagagctg ggagcgctgg     1260

cggcttgagc acttgcacat ccagagggac agcagcatga agcccctcaa gtgtcccacc     1320

agcagcctga gcagtggagc cacggcgggc agcagcatgt acacagccac ttgccaggcc     1380

tcctgcagca tgggctgcct cgggaacagt aagaccgagg accagcgcaa cgaggagaag     1440

gcgcagcgtg aggccaacaa aaagatcgag aagcagctgc agaaggacaa gcaggtctac     1500

cgggccacgc accgcctgct gctgctgggt gctggagaat ctggtaaaag caccattgtg     1560

aagcagatga ggatcctgca tgttaatggg tttaatggag agcacccaac ttttctatac     1620

aaagttgcca tgaccagcaa ggtgtacgac cccgagcaga ggaagaggat gatcaccggc     1680

ccccagtggt gggccaggtg caagcagatg aacgtgctgg acagcttcat caactactac     1740

gacagcgaga agcacgccga gaacgccgtg atcttcctgc acggcaacgc caccagcagc     1800

tacctgtgga ggcacgtggt gccccacatc gagcccgtgg ccaggtgcat catccccgat     1860

ctgatcggca tgggcaagag cggcaagagc ggcaacggca gctacaggct gctggaccac     1920

tacaagtacc tgaccgcctg gttcgagctc ctgaacctgc ccaagaagat catcttcgtg     1980

ggccacgact ggggagctgc actggccttc cactacgcct acgagcacca ggacagaatc     2040

aaggccatcg tgcacatgga gagcgtggtg gacgtgatcg agagctggga cgagtggcca     2100

gacatcgagg aggacatcgc cctgatcaag agcgaggagg gcgagaagat ggtgctggag     2160

aacaacttct tcgtggagac cgtcctgccc agcaagatca tgagaaagct ggagcccgag     2220

gagttcgccg cctacctgga gcccttcaag gagaagggcg aggtgagaag acccaccctg     2280

agctggccca gagagatccc cctggtgaag ggcggcaagc ccgacgtggt gcagatcgtg     2340

agaaactaca acgcctacct gagagccagc gacgacctgc ccaagctgtt catcgagagc     2400

gaccccggct tcttcagcaa cgccatcgtg gagggcgcca agaagttccc caacaccgag     2460

ttcgtgaagg tgaagggcct gcactttctc caggaagacg cccccgacga gatgggcaag     2520

tacatcaaga gcttcgtgga gagagtgctg aagaacgagc aaacaacttt gtataataaa     2580

gttgccagca acagcgatgg tgagaaggca accaaagtgc aggacatcaa aaacaacctg     2640

aaagaggcga ttgaaaccat tgtggccgcc atgagcaacc tggtgccccc cgtggagctg     2700

gccaaccccg agaaccagtt cagagtggac tacattctga gtgtgatgaa cgtgcctgac     2760

tttgacttcc ctcccgaatt ctatgagcat gccaaggctc tgtgggagga tgaaggagtg     2820

cgtgcctgct acgaacgctc caacgagtac cagctgattg actgtgccca gtacttcctg     2880

gacaagatcg acgtgatcaa gcaggctgac tatgtgccga gcgatcagga cctgcttcgc     2940

tgccgtgtcc tgacttctgg aatctttgag accaagttcc aggtggacaa agtcaacttc     3000

cacatgtttg acgtgggtgg ccagcgcgat gaacgccgca agtggatcca gtgcttcaac     3060

gatgtgactg ccatcatctt cgtggtggcc agcagcagct acaacatggt catccgggag     3120

gacaaccaga ccaaccgcct gcaggaggct ctgaacctct tcaagagcat ctggaacaac     3180

agatggctgc gcaccatctc tgtgatcctg ttcctcaaca agcaagatct gctcgctgag     3240

aaagtccttg ctgggaaatc gaagattgag gactactttc cagaatttgc tcgctacact     3300

actcctgagg atgctactcc cgagcccgga gaggacccac gcgtgacccg ggccaagtac     3360

ttcattcgag atgagtttct gaggatcagc actgccagtg gagatgggcg tcactactgc     3420

taccctcatt tcacctgcgc tgtggacact gagaacatcc gccgtgtgtt caacgactgc     3480

cgtgacatca ttcagcgcat gcaccttcgt cagtacgagc tgctctaa                  3528


<210>  20
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  GLP1R-G(1-71)-L-G(82-394) (RGLG-1) fusion protein

<400>  20

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser Met 
    450                 455                 460                 


Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu Lys 
465                 470                 475                 480 


Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys Asp 
                485                 490                 495     


Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala Gly 
            500                 505                 510         


Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His Val 
        515                 520                 525             


Asn Gly Phe Asn Gly Glu His Pro Thr Phe Leu Tyr Lys Val Ala Met 
    530                 535                 540                 


Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
545                 550                 555                 560 


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
                565                 570                 575     


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
            580                 585                 590         


Leu His Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro 
        595                 600                 605             


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
    610                 615                 620                 


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
625                 630                 635                 640 


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
                645                 650                 655     


Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr 
            660                 665                 670         


Ala Tyr Glu His Gln Asp Arg Ile Lys Ala Ile Val His Met Glu Ser 
        675                 680                 685             


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
    690                 695                 700                 


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
705                 710                 715                 720 


Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys 
                725                 730                 735     


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
            740                 745                 750         


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
        755                 760                 765             


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
    770                 775                 780                 


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser 
785                 790                 795                 800 


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
                805                 810                 815     


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Leu Gln Glu 
            820                 825                 830         


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
        835                 840                 845             


Val Leu Lys Asn Glu Gln Thr Thr Leu Tyr Asn Lys Val Ala Ser Asn 
    850                 855                 860                 


Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys Asn Asn Leu 
865                 870                 875                 880 


Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn Leu Val Pro 
                885                 890                 895     


Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile 
            900                 905                 910         


Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr 
        915                 920                 925             


Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr 
    930                 935                 940                 


Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu 
945                 950                 955                 960 


Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln 
                965                 970                 975     


Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys 
            980                 985                 990         


Phe Gln Val Asp Lys Val Asn Phe  His Met Phe Asp Val  Gly Gly Gln 
        995                 1000                 1005             


Arg Asp  Glu Arg Arg Lys Trp  Ile Gln Cys Phe Asn  Asp Val Thr 
    1010                 1015                 1020             


Ala Ile  Ile Phe Val Val Ala  Ser Ser Ser Tyr Asn  Met Val Ile 
    1025                 1030                 1035             


Arg Glu  Asp Asn Gln Thr Asn  Arg Leu Gln Glu Ala  Leu Asn Leu 
    1040                 1045                 1050             


Phe Lys  Ser Ile Trp Asn Asn  Arg Trp Leu Arg Thr  Ile Ser Val 
    1055                 1060                 1065             


Ile Leu  Phe Leu Asn Lys Gln  Asp Leu Leu Ala Glu  Lys Val Leu 
    1070                 1075                 1080             


Ala Gly  Lys Ser Lys Ile Glu  Asp Tyr Phe Pro Glu  Phe Ala Arg 
    1085                 1090                 1095             


Tyr Thr  Thr Pro Glu Asp Ala  Thr Pro Glu Pro Gly  Glu Asp Pro 
    1100                 1105                 1110             


Arg Val  Thr Arg Ala Lys Tyr  Phe Ile Arg Asp Glu  Phe Leu Arg 
    1115                 1120                 1125             


Ile Ser  Thr Ala Ser Gly Asp  Gly Arg His Tyr Cys  Tyr Pro His 
    1130                 1135                 1140             


Phe Thr  Cys Ala Val Asp Thr  Glu Asn Ile Arg Arg  Val Phe Asn 
    1145                 1150                 1155             


Asp Cys  Arg Asp Ile Ile Gln  Arg Met His Leu Arg  Gln Tyr Glu 
    1160                 1165                 1170             


Leu Leu  
    1175 


<210>  21
<211>  3537
<212>  DNA
<213>  Artificial

<220>
<223>  GIPR-G(1-71)-L-G(82-394) (RGLG-1) fusion protein encoding DNA

<400>  21
atgactacct ctccgatcct gcagctgctg ctgcggctct cactgtgcgg gctgctgctc       60

cagagggcgg agacaggctc taaggggcag acggcggggg agctgtacca gcgctgggaa      120

cggtaccgca gggagtgcca ggagaccttg gcagccgcgg aaccgccttc aggcctcgcc      180

tgtaacgggt ccttcgatat gtacgtctgc tgggactatg ctgcacccaa tgccactgcc      240

cgtgcgtcct gcccctggta cctgccctgg caccaccatg tggctgcagg tttcgtcctc      300

cgccagtgtg gtagtgatgg ccaatgggga ctttggagag accatacaca atgtgagaac      360

ccagagaaga atgaggcctt tctggaccaa aggctcatct tggagcggtt gcaggtcatg      420

tacactgtcg gctactccct gtctctcgcc acactgctgc tagccctgct catcttgagt      480

ttgttcaggc ggctacattg cactagaaac tatatccaca tcaacctgtt cacgtctttc      540

atgctgcgag ctgcggccat tctcagccga gaccgtctgc tacctcgacc tggcccctac      600

cttggggacc aggcccttgc gctgtggaac caggccctcg ctgcctgccg cacggcccag      660

atcgtgaccc agtactgcgt gggtgccaac tacacgtggc tgctggtgga gggcgtctac      720

ctgcacagtc tcctggtgct cgtgggaggc tccgaggagg gccacttccg ctactacctg      780

ctcctcggct ggggggcccc cgcgcttttc gtcattccct gggtgatcgt caggtacctg      840

tacgagaaca cgcagtgctg ggagcgcaac gaagtcaagg ccatttggtg gattatacgg      900

acccccatcc tcatgaccat cttgattaat ttcctcattt ttatccgcat tcttggcatt      960

ctcctgtcca agctgaggac acggcaaatg cgctgccggg attaccggct gaggctggct     1020

cgctccacgc tgacgctggt gcccctgctg ggtgtccacg aggtggtgtt tgctcccgtg     1080

acagaggaac aggcccgggg cgccctgcgc ttcgccaagc tcggctttga gatcttcctc     1140

agctccttcc agggcttcct ggtcagcgtc ctctactgct tcatcaacaa ggaggtgcag     1200

tcggagatcc gccgtggctg gcaccactgc cgcctgcgcc gcagcctggg cgaggagcaa     1260

cgccagctcc cggagcgcgc cttccgggcc ctgccctccg gctccggccc gggcgaggtc     1320

cccaccagcc gcggcttgtc ctcggggacc ctcccagggc ctgggaatga ggccagccgg     1380

gagttggaaa gttactgcat gggctgcctc gggaacagta agaccgagga ccagcgcaac     1440

gaggagaagg cgcagcgtga ggccaacaaa aagatcgaga agcagctgca gaaggacaag     1500

caggtctacc gggccacgca ccgcctgctg ctgctgggtg ctggagaatc tggtaaaagc     1560

accattgtga agcagatgag gatcctgcat gttaatgggt ttaatggaga gcacccaact     1620

tttctataca aagttgccat gaccagcaag gtgtacgacc ccgagcagag gaagaggatg     1680

atcaccggcc cccagtggtg ggccaggtgc aagcagatga acgtgctgga cagcttcatc     1740

aactactacg acagcgagaa gcacgccgag aacgccgtga tcttcctgca cggcaacgcc     1800

accagcagct acctgtggag gcacgtggtg ccccacatcg agcccgtggc caggtgcatc     1860

atccccgatc tgatcggcat gggcaagagc ggcaagagcg gcaacggcag ctacaggctg     1920

ctggaccact acaagtacct gaccgcctgg ttcgagctcc tgaacctgcc caagaagatc     1980

atcttcgtgg gccacgactg gggagctgca ctggccttcc actacgccta cgagcaccag     2040

gacagaatca aggccatcgt gcacatggag agcgtggtgg acgtgatcga gagctgggac     2100

gagtggccag acatcgagga ggacatcgcc ctgatcaaga gcgaggaggg cgagaagatg     2160

gtgctggaga acaacttctt cgtggagacc gtcctgccca gcaagatcat gagaaagctg     2220

gagcccgagg agttcgccgc ctacctggag cccttcaagg agaagggcga ggtgagaaga     2280

cccaccctga gctggcccag agagatcccc ctggtgaagg gcggcaagcc cgacgtggtg     2340

cagatcgtga gaaactacaa cgcctacctg agagccagcg acgacctgcc caagctgttc     2400

atcgagagcg accccggctt cttcagcaac gccatcgtgg agggcgccaa gaagttcccc     2460

aacaccgagt tcgtgaaggt gaagggcctg cactttctcc aggaagacgc ccccgacgag     2520

atgggcaagt acatcaagag cttcgtggag agagtgctga agaacgagca aacaactttg     2580

tataataaag ttgccagcaa cagcgatggt gagaaggcaa ccaaagtgca ggacatcaaa     2640

aacaacctga aagaggcgat tgaaaccatt gtggccgcca tgagcaacct ggtgcccccc     2700

gtggagctgg ccaaccccga gaaccagttc agagtggact acatcctgag tgtgatgaac     2760

gtgcctgact ttgacttccc tcccgaattc tatgagcatg ccaaggctct gtgggaggat     2820

gaaggagtgc gtgcctgcta cgaacgctcc aacgagtacc agctgattga ctgtgcccag     2880

tacttcctgg acaagatcga cgtgatcaag caggctgact atgtgccgag cgatcaggac     2940

ctgcttcgct gccgtgtcct gacttctgga atctttgaga ccaagttcca ggtggacaaa     3000

gtcaacttcc acatgtttga cgtgggtggc cagcgcgatg aacgccgcaa gtggatccag     3060

tgcttcaacg atgtgactgc catcatcttc gtggtggcca gcagcagcta caacatggtc     3120

atccgggagg acaaccagac caaccgcctg caggaggctc tgaacctctt caagagcatc     3180

tggaacaaca gatggctgcg caccatctct gtgatcctgt tcctcaacaa gcaagatctg     3240

ctcgctgaga aagtccttgc tgggaaatcg aagattgagg actactttcc agaatttgct     3300

cgctacacta ctcctgagga tgctactccc gagcccggag aggacccacg cgtgacccgg     3360

gccaagtact tcattcgaga tgagtttctg aggatcagca ctgccagtgg agatgggcgt     3420

cactactgct accctcattt cacctgcgct gtggacactg agaacatccg ccgtgtgttc     3480

aacgactgcc gtgacatcat tcagcgcatg caccttcgtc agtacgagct gctctaa        3537


<210>  22
<211>  1178
<212>  PRT
<213>  Artificial

<220>
<223>  GIPR-G(1-71)-L-G(82-394) (RGLG-1) fusion protein

<400>  22

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn 
465                 470                 475                 480 


Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu 
                485                 490                 495     


Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu 
            500                 505                 510         


Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile 
        515                 520                 525             


Leu His Val Asn Gly Phe Asn Gly Glu His Pro Thr Phe Leu Tyr Lys 
    530                 535                 540                 


Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met 
545                 550                 555                 560 


Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu 
                565                 570                 575     


Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala 
            580                 585                 590         


Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His 
        595                 600                 605             


Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu 
    610                 615                 620                 


Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu 
625                 630                 635                 640 


Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu 
                645                 650                 655     


Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala 
            660                 665                 670         


Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile Lys Ala Ile Val His 
        675                 680                 685             


Met Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp 
    690                 695                 700                 


Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met 
705                 710                 715                 720 


Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile 
                725                 730                 735     


Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe 
            740                 745                 750         


Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu 
        755                 760                 765             


Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg 
    770                 775                 780                 


Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe 
785                 790                 795                 800 


Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala 
                805                 810                 815     


Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe 
            820                 825                 830         


Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe 
        835                 840                 845             


Val Glu Arg Val Leu Lys Asn Glu Gln Thr Thr Leu Tyr Asn Lys Val 
    850                 855                 860                 


Ala Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
865                 870                 875                 880 


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
                885                 890                 895     


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
            900                 905                 910         


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
        915                 920                 925             


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
    930                 935                 940                 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
945                 950                 955                 960 


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
                965                 970                 975     


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
            980                 985                 990         


Glu Thr Lys Phe Gln Val Asp Lys  Val Asn Phe His Met  Phe Asp Val 
        995                 1000                 1005             


Gly Gly  Gln Arg Asp Glu Arg  Arg Lys Trp Ile Gln  Cys Phe Asn 
    1010                 1015                 1020             


Asp Val  Thr Ala Ile Ile Phe  Val Val Ala Ser Ser  Ser Tyr Asn 
    1025                 1030                 1035             


Met Val  Ile Arg Glu Asp Asn  Gln Thr Asn Arg Leu  Gln Glu Ala 
    1040                 1045                 1050             


Leu Asn  Leu Phe Lys Ser Ile  Trp Asn Asn Arg Trp  Leu Arg Thr 
    1055                 1060                 1065             


Ile Ser  Val Ile Leu Phe Leu  Asn Lys Gln Asp Leu  Leu Ala Glu 
    1070                 1075                 1080             


Lys Val  Leu Ala Gly Lys Ser  Lys Ile Glu Asp Tyr  Phe Pro Glu 
    1085                 1090                 1095             


Phe Ala  Arg Tyr Thr Thr Pro  Glu Asp Ala Thr Pro  Glu Pro Gly 
    1100                 1105                 1110             


Glu Asp  Pro Arg Val Thr Arg  Ala Lys Tyr Phe Ile  Arg Asp Glu 
    1115                 1120                 1125             


Phe Leu  Arg Ile Ser Thr Ala  Ser Gly Asp Gly Arg  His Tyr Cys 
    1130                 1135                 1140             


Tyr Pro  His Phe Thr Cys Ala  Val Asp Thr Glu Asn  Ile Arg Arg 
    1145                 1150                 1155             


Val Phe  Asn Asp Cys Arg Asp  Ile Ile Gln Arg Met  His Leu Arg 
    1160                 1165                 1170             


Gln Tyr  Glu Leu Leu 
    1175             


<210>  23
<211>  3375
<212>  DNA
<213>  Artificial

<220>
<223>  A2AR-G(1-71)-L-G(82-394) (RGLG-1) fusion protein encoding DNA

<400>  23
atgcccatca tgggctcctc ggtgtacatc acggtggagc tggccattgc tgtgctggcc       60

atcctgggca atgtgctggt gtgctgggcc gtgtggctca acagcaacct gcagaacgtc      120

accaactact ttgtggtgtc actggcggcg gccgacatcg cagtgggtgt gctcgccatc      180

ccctttgcca tcaccatcag caccgggttc tgcgctgcct gccacggctg cctcttcatt      240

gcctgcttcg tcctggtcct cacgcagagc tccatcttca gtctcctggc catcgccatt      300

gaccgctaca ttgccatccg catcccgctc cggtacaatg gcttggtgac cggcacgagg      360

gctaagggca tcattgccat ctgctgggtg ctgtcgtttg ccatcggcct gactcccatg      420

ctaggttgga acaactgcgg tcagccaaag gagggcaaga accactccca gggctgcggg      480

gagggccaag tggcctgtct ctttgaggat gtggtcccca tgaactacat ggtgtacttc      540

aacttctttg cctgtgtgct ggtgcccctg ctgctcatgc tgggtgtcta tttgcggatc      600

ttcctggcgg cgcgacgaca gctgaagcag atggagagcc agcctctgcc gggggagcgg      660

gcacggtcca cactgcagaa ggaggtccat gctgccaagt cactggccat cattgtgggg      720

ctctttgccc tctgctggct gcccctacac atcatcaact gcttcacttt cttctgcccc      780

gactgcagcc acgcccctct ctggctcatg tacctggcca tcgtcctctc ccacaccaat      840

tcggttgtga atcccttcat ctacgcctac cgtatccgcg agttccgcca gaccttccgc      900

aagatcattc gcagccacgt cctgaggcag caagaacctt tcaaggcagc tggcaccagt      960

gcccgggtct tggcagctca tggcagtgac ggagagcagg tcagcctccg tctcaacggc     1020

cacccgccag gagtgtgggc caacggcagt gctccccacc ctgagcggag gcccaatggc     1080

tatgccctgg ggctggtgag tggagggagt gcccaagagt cccaggggaa cacgggcctc     1140

ccagacgtgg agctccttag ccatgagctc aagggagtgt gcccagagcc ccctggccta     1200

gatgaccccc tggcccagga tggagcagga gtgtccatgg gctgcctcgg gaacagtaag     1260

accgaggacc agcgcaacga ggagaaggcg cagcgtgagg ccaacaaaaa gatcgagaag     1320

cagctgcaga aggacaagca ggtctaccgg gccacgcacc gcctgctgct gctgggtgct     1380

ggagaatctg gtaaaagcac cattgtgaag cagatgagga tcctgcatgt taatgggttt     1440

aatggagagc acccaacttt tctatacaaa gttgccatga ccagcaaggt gtacgacccc     1500

gagcagagga agaggatgat caccggcccc cagtggtggg ccaggtgcaa gcagatgaac     1560

gtgctggaca gcttcatcaa ctactacgac agcgagaagc acgccgagaa cgccgtgatc     1620

ttcctgcacg gcaacgccac cagcagctac ctgtggaggc acgtggtgcc ccacatcgag     1680

cccgtggcca ggtgcatcat ccccgatctg atcggcatgg gcaagagcgg caagagcggc     1740

aacggcagct acaggctgct ggaccactac aagtacctga ccgcctggtt cgagctcctg     1800

aacctgccca agaagatcat cttcgtgggc cacgactggg gagctgcact ggccttccac     1860

tacgcctacg agcaccagga cagaatcaag gccatcgtgc acatggagag cgtggtggac     1920

gtgatcgaga gctgggacga gtggccagac atcgaggagg acatcgccct gatcaagagc     1980

gaggagggcg agaagatggt gctggagaac aacttcttcg tggagaccgt cctgcccagc     2040

aagatcatga gaaagctgga gcccgaggag ttcgccgcct acctggagcc cttcaaggag     2100

aagggcgagg tgagaagacc caccctgagc tggcccagag agatccccct ggtgaagggc     2160

ggcaagcccg acgtggtgca gatcgtgaga aactacaacg cctacctgag agccagcgac     2220

gacctgccca agctgttcat cgagagcgac cccggcttct tcagcaacgc catcgtggag     2280

ggcgccaaga agttccccaa caccgagttc gtgaaggtga agggcctgca ctttctccag     2340

gaagacgccc ccgacgagat gggcaagtac atcaagagct tcgtggagag agtgctgaag     2400

aacgagcaaa caactttgta taataaagtt gccagcaaca gcgatggtga gaaggcaacc     2460

aaagtgcagg acatcaaaaa caacctgaaa gaggcgattg aaaccattgt ggccgccatg     2520

agcaacctgg tgccccccgt ggagctggcc aaccccgaga accagttcag agtggactac     2580

atcctgagtg tgatgaacgt gcctgacttt gacttccctc ccgaattcta tgagcatgcc     2640

aaggctctgt gggaggatga aggagtgcgt gcctgctacg aacgctccaa cgagtaccag     2700

ctgattgact gtgcccagta cttcctggac aagatcgacg tgatcaagca ggctgactat     2760

gtgccgagcg atcaggacct gcttcgctgc cgtgtcctga cttctggaat ctttgagacc     2820

aagttccagg tggacaaagt caacttccac atgtttgacg tgggtggcca gcgcgatgaa     2880

cgccgcaagt ggatccagtg cttcaacgat gtgactgcca tcatcttcgt ggtggccagc     2940

agcagctaca acatggtcat ccgggaggac aaccagacca accgcctgca ggaggctctg     3000

aacctcttca agagcatctg gaacaacaga tggctgcgca ccatctctgt gatcctgttc     3060

ctcaacaagc aagatctgct cgctgagaaa gtccttgctg ggaaatcgaa gattgaggac     3120

tactttccag aatttgctcg ctacactact cctgaggatg ctactcccga gcccggagag     3180

gacccacgcg tgacccgggc caagtacttc attcgagatg agtttctgag gatcagcact     3240

gccagtggag atgggcgtca ctactgctac cctcatttca cctgcgctgt ggacactgag     3300

aacatccgcc gtgtgttcaa cgactgccgt gacatcattc agcgcatgca ccttcgtcag     3360

tacgagctgc tctaa                                                      3375


<210>  24
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  A2AR-G(1-71)-L-G(82-394) (RGLG-1) fusion protein

<400>  24

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Thr Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser Met Gly Cys Leu 
                405                 410                 415     


Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu Lys Ala Gln Arg 
            420                 425                 430         


Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys Asp Lys Gln Val 
        435                 440                 445             


Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly 
    450                 455                 460                 


Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His Val Asn Gly Phe 
465                 470                 475                 480 


Asn Gly Glu His Pro Thr Phe Leu Tyr Lys Val Ala Met Thr Ser Lys 
                485                 490                 495     


Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp 
            500                 505                 510         


Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr 
        515                 520                 525             


Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His Gly 
    530                 535                 540                 


Asn Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile Glu 
545                 550                 555                 560 


Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser 
                565                 570                 575     


Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr 
            580                 585                 590         


Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe 
        595                 600                 605             


Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu 
    610                 615                 620                 


His Gln Asp Arg Ile Lys Ala Ile Val His Met Glu Ser Val Val Asp 
625                 630                 635                 640 


Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala 
                645                 650                 655     


Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn Phe 
            660                 665                 670         


Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu Glu Pro 
        675                 680                 685             


Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu Val 
    690                 695                 700                 


Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys Gly 
705                 710                 715                 720 


Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu 
                725                 730                 735     


Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro Gly 
            740                 745                 750         


Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr 
        755                 760                 765             


Glu Phe Val Lys Val Lys Gly Leu His Phe Leu Gln Glu Asp Ala Pro 
    770                 775                 780                 


Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys 
785                 790                 795                 800 


Asn Glu Gln Thr Thr Leu Tyr Asn Lys Val Ala Ser Asn Ser Asp Gly 
                805                 810                 815     


Glu Lys Ala Thr Lys Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala 
            820                 825                 830         


Ile Glu Thr Ile Val Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu 
        835                 840                 845             


Leu Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val 
    850                 855                 860                 


Met Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala 
865                 870                 875                 880 


Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser 
                885                 890                 895     


Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile 
            900                 905                 910         


Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu 
        915                 920                 925             


Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val 
    930                 935                 940                 


Asp Lys Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg Asp Glu 
945                 950                 955                 960 


Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile Ile Phe 
                965                 970                 975     


Val Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp Asn Gln 
            980                 985                 990         


Thr Asn Arg Leu Gln Glu Ala Leu  Asn Leu Phe Lys Ser  Ile Trp Asn 
        995                 1000                 1005             


Asn Arg  Trp Leu Arg Thr Ile  Ser Val Ile Leu Phe  Leu Asn Lys 
    1010                 1015                 1020             


Gln Asp  Leu Leu Ala Glu Lys  Val Leu Ala Gly Lys  Ser Lys Ile 
    1025                 1030                 1035             


Glu Asp  Tyr Phe Pro Glu Phe  Ala Arg Tyr Thr Thr  Pro Glu Asp 
    1040                 1045                 1050             


Ala Thr  Pro Glu Pro Gly Glu  Asp Pro Arg Val Thr  Arg Ala Lys 
    1055                 1060                 1065             


Tyr Phe  Ile Arg Asp Glu Phe  Leu Arg Ile Ser Thr  Ala Ser Gly 
    1070                 1075                 1080             


Asp Gly  Arg His Tyr Cys Tyr  Pro His Phe Thr Cys  Ala Val Asp 
    1085                 1090                 1095             


Thr Glu  Asn Ile Arg Arg Val  Phe Asn Asp Cys Arg  Asp Ile Ile 
    1100                 1105                 1110             


Gln Arg  Met His Leu Arg Gln  Tyr Glu Leu Leu 
    1115                 1120                 


<210>  25
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 1

<400>  25
ggggacaagt ttgtacaaaa aagcaggctt cgccaccatg gtgagcaagg gcgag            55


<210>  26
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 2

<400>  26
ctgagatcct gggccatgta cagctcgttc atgccctc                               38


<210>  27
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 3

<400>  27
gagggcatga acgagctgta catggcccag gatctcag                               38


<210>  28
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 4

<400>  28
ggggaccact ttgtacaaga aagctgggta tcagcttatc agacagccac                  50


<210>  29
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 5

<400>  29
gaaaggtggc tgtctgataa gcatggtgag caagggcgag                             40


<210>  30
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 6

<400>  30
ggggaccact ttgtacaaga aagctgggta tcagtacagc tcgttcatgc cct              53


<210>  31
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 7

<400>  31
ggggacaagt ttgtacaaaa aagcaggctt cgccaccatg gcccaggatc tcagcga          57


<210>  32
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 8

<400>  32
ctcgcccttg ctcaccatgc ttatcagaca gccacctttc                             40


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 9

<400>  33
agtctcagct gcaggaggcc a                                                 21


<210>  34
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 10

<400>  34
gtcctgaact ccccgccat                                                    19


<210>  35
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 11

<400>  35
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgg ccggcgcccc       60

cggcccgct                                                               69


<210>  36
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 12

<400>  36
ggggacaact ttgtatagaa aagttgggtg gctgcaggag gcctggcaag tg               52


<210>  37
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 13

<400>  37
ggggacaact tttctataca aagttgccat gaccagcaag gtgtacgacc c                51


<210>  38
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 14

<400>  38
ggggacaact ttattataca aagttgtctc gttcttcagc actctctcc                   49


<210>  39
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 15

<400>  39
atgggctgcc tcgggaa                                                      17


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 16

<400>  40
ttagagcagc tcgtactgac                                                   20


<210>  41
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 17

<400>  41
ggggacaact ttgtataata aagttgccat gggctgcctc gggaac                      46


<210>  42
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 18

<400>  42
ggggaccact ttgtacaaga aagctgggta ttagagcagc tcgtactgac                  50


<210>  43
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 19

<400>  43
atcccgcccc ctagcagt                                                     18


<210>  44
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 20

<400>  44
acgaaccaga cccttcgc                                                     18


<210>  45
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 21

<400>  45
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga ctacctctcc       60

gatcctgcag ct                                                           72


<210>  46
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 22

<400>  46
ggggacaact ttgtatagaa aagttgggtg gcagtaactt tccaactc                    48


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 23

<400>  47
atgcccatca tgggctcctc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 24

<400>  48
tcaggacact cctgctccat                                                   20


<210>  49
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 25

<400>  49
ggggacaagt ttgtacaaaa aagcaggctt catgcccatc atgggctcct cg               52


<210>  50
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 26

<400>  50
ggggacaact ttgtatagaa aagttgggtg ggacactcct gctccatcct g                51


<210>  51
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 27

<400>  51
ggggacaact tttctataca aagttgccat gggctgcctc gggaa                       45


<210>  52
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 28

<400>  52
ggggacaact ttattataca aagttgtgag cagctcgtac tgacg                       45


<210>  53
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 29

<400>  53
ggggacaact ttgtataata aagttgccat gaccagcaag gtgtac                      46


<210>  54
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 30

<400>  54
ggggaccact ttgtacaaga aagctgggta ttacttgtca tcgtcgtcct                  50


<210>  55
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 31

<400>  55
ggggacaagt ttgtacaaaa aagcaggctt cgccaccatg ggctgcctcg ggaacagtaa       60

g                                                                       61


<210>  56
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 32

<400>  56
ggggacaact ttgtatagaa aagttgggtg ctctccatta aacccattaa catg             54


<210>  57
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 33

<400>  57
ggggacaact ttattataca aagttgtttg ctcgttcttc agcactctct c                51


<210>  58
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 34

<400>  58
ggggacaact tttctataca aagttgccat gaccagcaag gtgtacgacc c                51


<210>  59
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 35

<400>  59
ggggacaact ttgtataata aagttgccag caacagcgat ggtgagaagg                  50


<210>  60
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 36

<400>  60
ggggaccact ttgtacaaga aagctgggta ttagagcagc tcgtactgac                  50


<210>  61
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 37

<400>  61
ggggacaagt ttgtacaaaa aagcaggctt cgccaccatg gccggcgccc ccggcccgct       60

g                                                                       61


<210>  62
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 38

<400>  62
ttcccgaggc agcccatgct gcaggaggcc tg                                     32


<210>  63
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 39

<400>  63
caggcctcct gcagcatggg ctgcctcggg aa                                     32


<210>  64
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 40

<400>  64
ttcccgaggc agcccatgca gtaactttcc aactcc                                 36


<210>  65
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 41

<400>  65
tggaaagtta ctgcatgggc tgcctcggga a                                      31


<210>  66
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 42

<400>  66
ggggacaagt ttgtacaaaa aagcaggctt catgcccatc atgggctcct cg               52


<210>  67
<211>  33
<212>  DNA
<213>  Artificial 44

<220>
<223>  Primer 43

<400>  67
ttcccgaggc agcccatgga cactcctgct cca                                    33


<210>  68
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 44

<400>  68
tggagcagga gtgtccatgg gctgcctcgg gaa                                    33


<210>  69
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 45

<400>  69
ggggaccact ttgtacaaga aagctgggta ttagagcagc tcgtactgac                  50


<210>  70
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 46

<400>  70
ggggacaagt ttgtacaaaa aagcaggctt catgcccatc atgggctcct cg               52


<210>  71
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 47

<400>  71
ggggaccact ttgtacaaga aagctgggta ttagagcagc tcgtactgac                  50


<210>  72
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Linker motif 1 in fusion proteins

<400>  72

His Pro Thr Phe Leu Tyr Lys Val Gly 
1               5                   


<210>  73
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Linker motif 2 in fusion proteins

<400>  73

Thr Thr Leu Tyr Asn Lys Val Ala 
1               5               


<210>  74
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 48

<400>  74
atgggatgta ctctgagcgc agag                                              24


<210>  75
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 49

<400>  75
tcagtacaag ccgcagcc                                                     18


<210>  76
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 50

<400>  76
ggggacaagt ttgtacaaaa aagcaggctc tggaggcgga ggatctatgg gatgtactct       60

gagcgcagag                                                              70


<210>  77
<211>  73
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 51

<400>  77
ggggacaact ttgtatagaa aagttgggtg agatccgcct cctccagaca aagtgtccat       60

ggcccggacg atg                                                          73


<210>  78
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 52

<400>  78
ggggacaact ttgtataata aagttgcctc tggaggagga ggctctggca tcgaatatgg       60

tgataaggag                                                              70


<210>  79
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 53

<400>  79
ggggaccact ttgtacaaga aagctgggta tcagtacaag ccgcagcc                    48


<210>  80
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 54

<400>  80
ggggacaagt ttgtacaaaa aagcaggctt cgccaccatg gccaacttca cacctgtc         58


<210>  81
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 55

<400>  81
agtacatccc atagatcctc cgcctccaga cctggcagtg ccgatgttcc gatactggca       60


<210>  82
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Primer 56

<400>  82
tgccagtatc ggaacatcgg cactgccagg tctggaggcg gaggatctat gggatgtact       60


<210>  83
<211>  3540
<212>  DNA
<213>  Artificial

<220>
<223>  hM4R-Go(1-91)-L-Go(92-354) (RGLG-2)) fusion protein encoding DNA

<400>  83
atggccaact tcacacctgt caatggcagc tcgggcaatc agtccgtgcg cctggtcacg       60

tcatcatccc acaatcgcta tgagacggtg gaaatggtct tcattgccac agtgacaggc      120

tccctgagcc tggtgactgt cgtgggcaac atcctggtga tgctgtccat caaggtcaac      180

aggcagctgc agacagtcaa caactacttc ctcttcagcc tggcgtgtgc tgatctcatc      240

ataggcgcct tctccatgaa cctctacacc gtgtacatca tcaagggcta ctggcccctg      300

ggcgccgtgg tctgcgacct gtggctggcc ctggactacg tggtgagcaa cgcctccgtc      360

atgaaccttc tcatcatcag ctttgaccgc tacttctgcg tcaccaagcc tctcacctac      420

cctgcccggc gcaccaccaa gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc      480

ttcgtgctct gggcgcctgc catcttgttc tggcagtttg tggtgggtaa gcggacggtg      540

cccgacaacc agtgcttcat ccagttcctg tccaacccag cagtgacctt tggcacagcc      600

attgctgcct tctacctgcc tgtggtcatc atgacggtgc tgtacatcca catctccctg      660

gccagtcgca gccgagtcca caagcaccgg cccgagggcc cgaaggagaa gaaagccaag      720

acgctggcct tcctcaagag cccactaatg aagcagagcg tcaagaagcc cccgcccggg      780

gaggccgccc gggaggagct gcgcaatggc aagctggagg aggccccccc gccagcgctg      840

ccaccgccac cgcgccccgt ggctgataag gacacttcca atgagtccag ctcaggcagt      900

gccacccaga acaccaagga acgcccagcc acagagctgt ccaccacaga ggccaccacg      960

cccgccatgc ccgcccctcc cctgcagccg cgggccctca acccagcctc cagatggtcc     1020

aagatccaga ttgtgacgaa gcagacaggc aatgagtgtg tgacagccat tgagattgtg     1080

cctgccacgc cggctggcat gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc     1140

gctcgcaacc aggtgcgcaa gaagcggcag atggcggccc gggagcgcaa agtgacacga     1200

acgatctttg ccattctgct agccttcatc ctcacctgga cgccctacaa cgtcatggtc     1260

ctggtgaaca ccttctgcca gagctgcatc cctgacacgg tgtggtccat tggctactgg     1320

ctctgctacg tcaacagcac catcaaccct gcctgctatg ctctgtgcaa cgccaccttt     1380

aaaaagacct tccggcacct gctgctgtgc cagtatcgga acatcggcac tgccaggtct     1440

ggaggcggag gatctatggg atgtactctg agcgcagagg agagagccgc cctcgagcgg     1500

agcaaggcga ttgagaaaaa cctcaaagag gatggcatca gcgccgccaa agacgtgaaa     1560

ttactcctgc tcggggctgg agaatcagga aaaagcacca ttgtgaagca gatgaagatc     1620

atccatgaag atggcttctc cggagaagac gtgaaacagt acaagcctgt tgtctacagc     1680

aacactatcc agtccctggc agccatcgtc cgggccatgg acactttgtc tggaggaggc     1740

ggatctcacc caacttttct atacaaagtt gccatgacca gcaaggtgta cgaccccgag     1800

cagaggaaga ggatgatcac cggcccccag tggtgggcca ggtgcaagca gatgaacgtg     1860

ctggacagct tcatcaacta ctacgacagc gagaagcacg ccgagaacgc cgtgatcttc     1920

ctgcacggca acgccaccag cagctacctg tggaggcacg tggtgcccca catcgagccc     1980

gtggccaggt gcatcatccc cgatctgatc ggcatgggca agagcggcaa gagcggcaac     2040

ggcagctaca ggctgctgga ccactacaag tacctgaccg cctggttcga gctcctgaac     2100

ctgcccaaga agatcatctt cgtgggccac gactggggag ctgcactggc cttccactac     2160

gcctacgagc accaggacag aatcaaggcc atcgtgcaca tggagagcgt ggtggacgtg     2220

atcgagagct gggacgagtg gccagacatc gaggaggaca tcgccctgat caagagcgag     2280

gagggcgaga agatggtgct ggagaacaac ttcttcgtgg agaccgtcct gcccagcaag     2340

atcatgagaa agctggagcc cgaggagttc gccgcctacc tggagccctt caaggagaag     2400

ggcgaggtga gaagacccac cctgagctgg cccagagaga tccccctggt gaagggcggc     2460

aagcccgacg tggtgcagat cgtgagaaac tacaacgcct acctgagagc cagcgacgac     2520

ctgcccaagc tgttcatcga gagcgacccc ggcttcttca gcaacgccat cgtggagggc     2580

gccaagaagt tccccaacac cgagttcgtg aaggtgaagg gcctgcactt tctccaggaa     2640

gacgcccccg acgagatggg caagtacatc aagagcttcg tggagagagt gctgaagaac     2700

gagcaaacaa ctttgtataa taaagttgcc tctggaggag gaggctctgg catcgaatat     2760

ggtgataagg agagaaaggc tgacgccaag atggtgtgtg atgtggtgag tcggatggaa     2820

gacaccgagc ccttctctgc agagctgctt tctgccatga tgcggctctg gggcgactca     2880

ggaatccaag agtgcttcaa ccggtcccgg gagtatcagc tcaacgactc tgccaaatac     2940

tacctggaca gcctggatcg gattggggcc gccgactacc agcccactga gcaggacatc     3000

ctccgaacca gggtcaaaac cactggcatc gtagaaaccc acttcacatt caagaacctc     3060

cacttcaggc tgtttgacgt cggaggccag cgatctgaac gcaagaagtg gatccattgc     3120

ttcgaggacg tcacggccat cattttctgt gtcgcgctca gcggctatga ccaggtgctc     3180

cacgaagacg aaaccacgaa ccgcatgcac gagtctctca tgctcttcga ctccatctgt     3240

aacaacaagt tcttcatcga tacctccatc attctcttcc tcaacaagaa agatctcttt     3300

ggcgagaaga tcaagaagtc acctttgacc atctgctttc ctgaatacac aggccccaat     3360

acctatgaag acgcagccgc ctacatccaa gcacaatttg aaagcaaaaa ccgctcaccc     3420

aacaaagaaa tatattgtca catgacttgt gccacagaca cgaataacat ccaggtggtg     3480

ttcgacgccg tcaccgacat catcattgcc aacaacctcc ggggctgcgg cttgtactga     3540


<210>  84
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  hM4R-Go(1-91)-L-Go(92-354) (RGLG-2)) fusion protein

<400>  84

Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val 
1               5                   10                  15      


Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met 
            20                  25                  30          


Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val 
        35                  40                  45              


Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln 
    50                  55                  60                  


Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile 
65                  70                  75                  80  


Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly 
                85                  90                  95      


Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp 
            100                 105                 110         


Tyr Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe 
        115                 120                 125             


Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg 
    130                 135                 140                 


Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser 
145                 150                 155                 160 


Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly 
                165                 170                 175     


Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn 
            180                 185                 190         


Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro Val 
        195                 200                 205             


Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser 
    210                 215                 220                 


Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys 
                245                 250                 255     


Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu 
            260                 265                 270         


Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala 
        275                 280                 285             


Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn 
    290                 295                 300                 


Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr 
305                 310                 315                 320 


Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala 
                325                 330                 335     


Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu 
            340                 345                 350         


Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg 
        355                 360                 365             


Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln 
    370                 375                 380                 


Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg 
385                 390                 395                 400 


Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr 
                405                 410                 415     


Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp 
            420                 425                 430         


Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile 
        435                 440                 445             


Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe 
    450                 455                 460                 


Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala 
                485                 490                 495     


Ala Leu Glu Arg Ser Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly 
            500                 505                 510         


Ile Ser Ala Ala Lys Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu 
        515                 520                 525             


Ser Gly Lys Ser Thr Ile Val Lys Gln Met Lys Ile Ile His Glu Asp 
    530                 535                 540                 


Gly Phe Ser Gly Glu Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser 
545                 550                 555                 560 


Asn Thr Ile Gln Ser Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser His Pro Thr Phe Leu Tyr Lys Val Ala Met 
            580                 585                 590         


Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
        595                 600                 605             


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
    610                 615                 620                 


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
625                 630                 635                 640 


Leu His Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro 
                645                 650                 655     


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
            660                 665                 670         


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
        675                 680                 685             


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
    690                 695                 700                 


Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr 
705                 710                 715                 720 


Ala Tyr Glu His Gln Asp Arg Ile Lys Ala Ile Val His Met Glu Ser 
                725                 730                 735     


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
            740                 745                 750         


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
        755                 760                 765             


Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys 
    770                 775                 780                 


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
785                 790                 795                 800 


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
                805                 810                 815     


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
            820                 825                 830         


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser 
        835                 840                 845             


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
    850                 855                 860                 


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Leu Gln Glu 
865                 870                 875                 880 


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
                885                 890                 895     


Val Leu Lys Asn Glu Gln Thr Thr Leu Tyr Asn Lys Val Ala Ser Gly 
            900                 905                 910         


Gly Gly Gly Ser Gly Ile Glu Tyr Gly Asp Lys Glu Arg Lys Ala Asp 
        915                 920                 925             


Ala Lys Met Val Cys Asp Val Val Ser Arg Met Glu Asp Thr Glu Pro 
    930                 935                 940                 


Phe Ser Ala Glu Leu Leu Ser Ala Met Met Arg Leu Trp Gly Asp Ser 
945                 950                 955                 960 


Gly Ile Gln Glu Cys Phe Asn Arg Ser Arg Glu Tyr Gln Leu Asn Asp 
                965                 970                 975     


Ser Ala Lys Tyr Tyr Leu Asp Ser Leu Asp Arg Ile Gly Ala Ala Asp 
            980                 985                 990         


Tyr Gln Pro Thr Glu Gln Asp Ile  Leu Arg Thr Arg Val  Lys Thr Thr 
        995                 1000                 1005             


Gly Ile  Val Glu Thr His Phe  Thr Phe Lys Asn Leu  His Phe Arg 
    1010                 1015                 1020             


Leu Phe  Asp Val Gly Gly Gln  Arg Ser Glu Arg Lys  Lys Trp Ile 
    1025                 1030                 1035             


His Cys  Phe Glu Asp Val Thr  Ala Ile Ile Phe Cys  Val Ala Leu 
    1040                 1045                 1050             


Ser Gly  Tyr Asp Gln Val Leu  His Glu Asp Glu Thr  Thr Asn Arg 
    1055                 1060                 1065             


Met His  Glu Ser Leu Met Leu  Phe Asp Ser Ile Cys  Asn Asn Lys 
    1070                 1075                 1080             


Phe Phe  Ile Asp Thr Ser Ile  Ile Leu Phe Leu Asn  Lys Lys Asp 
    1085                 1090                 1095             


Leu Phe  Gly Glu Lys Ile Lys  Lys Ser Pro Leu Thr  Ile Cys Phe 
    1100                 1105                 1110             


Pro Glu  Tyr Thr Gly Pro Asn  Thr Tyr Glu Asp Ala  Ala Ala Tyr 
    1115                 1120                 1125             


Ile Gln  Ala Gln Phe Glu Ser  Lys Asn Arg Ser Pro  Asn Lys Glu 
    1130                 1135                 1140             


Ile Tyr  Cys His Met Thr Cys  Ala Thr Asp Thr Asn  Asn Ile Gln 
    1145                 1150                 1155             


Val Val  Phe Asp Ala Val Thr  Asp Ile Ile Ile Ala  Asn Asn Leu 
    1160                 1165                 1170             


Arg Gly  Cys Gly Leu Tyr 
    1175                 


<210>  85
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  85

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  86
<211>  3498
<212>  DNA
<213>  Artificial

<220>
<223>  hM1R-Gq[1-124]-L-Gq(125-359) (RGLG-3) fusion protein encoding DNA

<400>  86
atgaacactt cagccccacc tgctgtcagc cccaacatca ccgtcctggc accaggaaag       60

ggtccctggc aagtggcctt cattgggatc accacgggcc tcctgtcgct agccacagtg      120

acaggcaacc tgctggtact catctctttc aaggtcaaca cggagctcaa gacagtcaat      180

aactacttcc tgctgagcct ggcctgtgct gacctcatca tcggtacctt ctccatgaac      240

ctctatacca cgtacctgct catgggccac tgggctctgg gcacgctggc ttgtgacctc      300

tggctggccc tggactatgt ggccagcaat gcctccgtca tgaatctgct gctcatcagc      360

tttgaccgct acttctccgt gactcggccc ctgagctacc gtgccaagcg cacaccccgc      420

cgggcagctc tgatgatcgg cctggcctgg ctggtttcct ttgtgctctg ggccccagcc      480

atcctcttct ggcagtacct ggtaggggag cggacagtgc tagctgggca gtgctacatc      540

cagttcctct cccagcccat catcaccttt ggcacagcca tggctgcctt ctacctccct      600

gtcacagtca tgtgcacgct ctactggcgc atctaccggg agacagagaa ccgagcacgg      660

gagctggcag cccttcaggg ctccgagacg ccaggcaaag ggggtggcag cagcagcagc      720

tcagagaggt ctcagccagg ggctgagggc tcaccagaga ctcctccagg ccgctgctgt      780

cgctgctgcc gggcccccag gctgctgcag gcctacagct ggaaggaaga agaggaagag      840

gacgaaggct ccatggagtc cctcacatcc tcagagggag aggagcctgg ctccgaagtg      900

gtgatcaaga tgccaatggt ggaccccgag gcacaggccc ccaccaagca gcccccacgg      960

agctccccaa atacagtcaa gaggccgact aagaaagggc gtgatcgagc tggcaagggc     1020

cagaagcccc gtggaaagga gcagctggcc aagcggaaga ccttctcgct ggtcaaggag     1080

aagaaggcgg ctcggaccct gagtgccatc ctcctggcct tcatcctcac ctggacaccg     1140

tacaacatca tggtgctggt gtccaccttc tgcaaggact gtgttcccga gaccctgtgg     1200

gagctgggct actggctgtg ctacgtcaac agcaccatca accccatgtg ctacgcactc     1260

tgcaacaaag ccttccggga cacctttcgc ctgctgctgc tttgccgctg ggacaagaga     1320

cgctggcgca agatccccaa gcgccctggc tccgtgcacc gcactccctc ccgccaatgc     1380

tctggaggcg gaggatctat gactctggag tccatcatgg cgtgctgcct gagcgaggag     1440

gccaaggaag cccggcggat caacgacgag atcgagcggc agctccgcag ggacaagcgg     1500

gacgcccgcc gggagctcaa gctgctgctg ctcgggacag gagagagtgg caagagtacg     1560

tttatcaagc agatgagaat catccatggg tcaggatact ctgatgaaga taaaaggggc     1620

ttcaccaagc tggtgtatca gaacatcttc acggccatgc aggccatgat cagagccatg     1680

gacacactca agatcccata caagtatgag cacaataagg ctcatgcaca attagttcga     1740

gaagttgatg tggagaaggt gtctgctttt tctggaggag gcggatctca cccaactttt     1800

ctatacaaag ttgccatgac cagcaaggtg tacgaccccg agcagaggaa gaggatgatc     1860

accggccccc agtggtgggc caggtgcaag cagatgaacg tgctggacag cttcatcaac     1920

tactacgaca gcgagaagca cgccgagaac gccgtgatct tcctgcacgg caacgccacc     1980

agcagctacc tgtggaggca cgtggtgccc cacatcgagc ccgtggccag gtgcatcatc     2040

cccgatctga tcggcatggg caagagcggc aagagcggca acggcagcta caggctgctg     2100

gaccactaca agtacctgac cgcctggttc gagctcctga acctgcccaa gaagatcatc     2160

ttcgtgggcc acgactgggg agctgcactg gccttccact acgcctacga gcaccaggac     2220

agaatcaagg ccatcgtgca catggagagc gtggtggacg tgatcgagag ctgggacgag     2280

tggccagaca tcgaggagga catcgccctg atcaagagcg aggagggcga gaagatggtg     2340

ctggagaaca acttcttcgt ggagaccgtc ctgcccagca agatcatgag aaagctggag     2400

cccgaggagt tcgccgccta cctggagccc ttcaaggaga agggcgaggt gagaagaccc     2460

accctgagct ggcccagaga gatccccctg gtgaagggcg gcaagcccga cgtggtgcag     2520

atcgtgagaa actacaacgc ctacctgaga gccagcgacg acctgcccaa gctgttcatc     2580

gagagcgacc ccggcttctt cagcaacgcc atcgtggagg gcgccaagaa gttccccaac     2640

accgagttcg tgaaggtgaa gggcctgcac tttctccagg aagacgcccc cgacgagatg     2700

ggcaagtaca tcaagagctt cgtggagaga gtgctgaaga acgagcaaac aactttgtat     2760

aataaagttg cctctggagg aggaggctct gagaatccat atgtagatgc aataaagagt     2820

ttatggaatg atcctggaat ccaggaatgc tatgatagac gacgagaata tcaattatct     2880

gactctacca aatactatct taatgacttg gaccgcgtag ctgaccctgc ctacctgcct     2940

acgcaacaag atgtgcttag agttcgagtc cccaccacag ggatcatcga ataccccttt     3000

gacttacaaa gtgtcatttt cagaatggtc gatgtagggg gccaaaggtc agagagaaga     3060

aaatggatac actgctttga aaatgtcacc tctatcatgt ttctagtagc gcttagtgaa     3120

tatgatcaag ttctcgtgga gtcagacaat gagaaccgaa tggaggaaag caaggctctc     3180

tttagaacaa ttatcacata cccctggttc cagaactcct cggttattct gttcttaaac     3240

aagaaagatc ttctagagga gaaaatcatg tattcccatc tagtcgacta cttcccagaa     3300

tatgatggac cccagagaga tgcccaggca gcccgagaat tcattctgaa gatgttcgtg     3360

gacctgaacc cagacagtga caaaattatc tactcccact tcacgtgcgc cacagacacc     3420

gagaatatcc gctttgtctt tgctgccgtc aaggacacca tcctccagtt gaacctgaag     3480

gagtacaatc tggtctaa                                                   3498


<210>  87
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  hM1R-Gq[1-124]-L-Gq(125-359) (RGLG-3) fusion protein

<400>  87

Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu 
465                 470                 475                 480 


Ala Lys Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg 
                485                 490                 495     


Arg Asp Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly 
            500                 505                 510         


Thr Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile 
        515                 520                 525             


His Gly Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu 
    530                 535                 540                 


Val Tyr Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met 
545                 550                 555                 560 


Asp Thr Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala 
                565                 570                 575     


Gln Leu Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser His Pro Thr Phe Leu Tyr Lys Val Ala Met Thr Ser 
        595                 600                 605             


Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln 
    610                 615                 620                 


Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn 
625                 630                 635                 640 


Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His 
                645                 650                 655     


Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile 
            660                 665                 670         


Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys 
        675                 680                 685             


Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys 
    690                 695                 700                 


Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile 
705                 710                 715                 720 


Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr 
                725                 730                 735     


Glu His Gln Asp Arg Ile Lys Ala Ile Val His Met Glu Ser Val Val 
            740                 745                 750         


Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile 
        755                 760                 765             


Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn 
    770                 775                 780                 


Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu Glu 
785                 790                 795                 800 


Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu 
                805                 810                 815     


Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys 
            820                 825                 830         


Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr 
        835                 840                 845             


Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro 
    850                 855                 860                 


Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn 
865                 870                 875                 880 


Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Leu Gln Glu Asp Ala 
                885                 890                 895     


Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu 
            900                 905                 910         


Lys Asn Glu Gln Thr Thr Leu Tyr Asn Lys Val Ala Ser Gly Gly Gly 
        915                 920                 925             


Gly Ser Glu Asn Pro Tyr Val Asp Ala Ile Lys Ser Leu Trp Asn Asp 
    930                 935                 940                 


Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser 
945                 950                 955                 960 


Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu Asp Arg Val Ala Asp Pro 
                965                 970                 975     


Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu Arg Val Arg Val Pro Thr 
            980                 985                 990         


Thr Gly Ile Ile Glu Tyr Pro Phe  Asp Leu Gln Ser Val  Ile Phe Arg 
        995                 1000                 1005             


Met Val  Asp Val Gly Gly Gln  Arg Ser Glu Arg Arg  Lys Trp Ile 
    1010                 1015                 1020             


His Cys  Phe Glu Asn Val Thr  Ser Ile Met Phe Leu  Val Ala Leu 
    1025                 1030                 1035             


Ser Glu  Tyr Asp Gln Val Leu  Val Glu Ser Asp Asn  Glu Asn Arg 
    1040                 1045                 1050             


Met Glu  Glu Ser Lys Ala Leu  Phe Arg Thr Ile Ile  Thr Tyr Pro 
    1055                 1060                 1065             


Trp Phe  Gln Asn Ser Ser Val  Ile Leu Phe Leu Asn  Lys Lys Asp 
    1070                 1075                 1080             


Leu Leu  Glu Glu Lys Ile Met  Tyr Ser His Leu Val  Asp Tyr Phe 
    1085                 1090                 1095             


Pro Glu  Tyr Asp Gly Pro Gln  Arg Asp Ala Gln Ala  Ala Arg Glu 
    1100                 1105                 1110             


Phe Ile  Leu Lys Met Phe Val  Asp Leu Asn Pro Asp  Ser Asp Lys 
    1115                 1120                 1125             


Ile Ile  Tyr Ser His Phe Thr  Cys Ala Thr Asp Thr  Glu Asn Ile 
    1130                 1135                 1140             


Arg Phe  Val Phe Ala Ala Val  Lys Asp Thr Ile Leu  Gln Leu Asn 
    1145                 1150                 1155             


Leu Lys  Glu Tyr Asn Leu Val  
    1160                 1165 


<210>  88
<211>  3501
<212>  DNA
<213>  Artificial

<220>
<223>  hM2R-Go[1-91]-L-Go(92-354) (RGLG-2) fusion protein encoding DNA

<400>  88
atgaataact caacaaactc ctctaacaat agcctggctc ttacaagtcc ttataagaca       60

tttgaagtgg tgtttattgt cctggtggct ggatccctca gtttggtgac cattatcggg      120

aacatcctag tcatggtttc cattaaagtc aaccgccacc tccagaccgt caacaattac      180

tttttattca gcttggcctg tgctgacctt atcataggtg ttttctccat gaacttgtac      240

accctctaca ctgtgattgg ttactggcct ttgggacctg tggtgtgtga cctttggcta      300

gccctggact atgtggtcag caatgcctca gttatgaatc tgctcatcat cagctttgac      360

aggtacttct gtgtcacaaa acctctgacc tacccagtca agcggaccac aaaaatggca      420

ggtatgatga ttgcagctgc ctgggtcctc tctttcatcc tctgggctcc agccattctc      480

ttctggcagt tcattgtagg ggtgagaact gtggaggatg gggagtgcta cattcagttt      540

ttttccaatg ctgctgtcac ctttggtacg gctattgcag ccttctattt gccagtgatc      600

atcatgactg tgctatattg gcacatatcc cgagccagca agagcaggat aaagaaggac      660

aagaaggagc ctgttgccaa ccaagacccc gtttctccaa gtctggtaca aggaaggata      720

gtgaagccaa acaataacaa catgcccagc agtgacgatg gcctggagca caacaaaatc      780

cagaatggca aagcccccag ggatcctgtg actgaaaact gtgttcaggg agaggagaag      840

gagagctcca atgactccac ctcagtcagt gctgttgcct ctaatatgag agatgatgaa      900

ataacccagg atgaaaacac agtttccact tccctgggcc attccaaaga tgagaactct      960

aagcaaacat gcatcagaat tggcaccaag accccaaaaa gtgactcatg taccccaact     1020

aataccaccg tggaggtagt ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt     1080

gtagcccgca agattgtgaa gatgactaag cagcctgcaa aaaagaagcc tcctccttcc     1140

cgggaaaaga aagtcaccag gacaatcttg gctattctgt tggctttcat catcacttgg     1200

gccccataca atgtcatggt gctcattaac accttttgtg caccttgcat ccccaacact     1260

gtgtggacaa ttggttactg gctttgttac atcaacagca ctatcaaccc tgcctgctat     1320

gcactttgca atgccacctt caagaagacc tttaaacacc ttctcatgtg tcattataag     1380

aacataggcg ctacaaggtc tggaggcgga ggatctatgg gatgtactct gagcgcagag     1440

gagagagccg ccctcgagcg gagcaaggcg attgagaaaa acctcaaaga ggatggcatc     1500

agcgccgcca aagacgtgaa attactcctg ctcggggctg gagaatcagg aaaaagcacc     1560

attgtgaagc agatgaagat catccatgaa gatggcttct ccggagaaga cgtgaaacag     1620

tacaagcctg ttgtctacag caacactatc cagtccctgg cagccatcgt ccgggccatg     1680

gacactttgt ctggaggagg cggatctcac ccaacttttc tatacaaagt tgccatgacc     1740

agcaaggtgt acgaccccga gcagaggaag aggatgatca ccggccccca gtggtgggcc     1800

aggtgcaagc agatgaacgt gctggacagc ttcatcaact actacgacag cgagaagcac     1860

gccgagaacg ccgtgatctt cctgcacggc aacgccacca gcagctacct gtggaggcac     1920

gtggtgcccc acatcgagcc cgtggccagg tgcatcatcc ccgatctgat cggcatgggc     1980

aagagcggca agagcggcaa cggcagctac aggctgctgg accactacaa gtacctgacc     2040

gcctggttcg agctcctgaa cctgcccaag aagatcatct tcgtgggcca cgactgggga     2100

gctgcactgg ccttccacta cgcctacgag caccaggaca gaatcaaggc catcgtgcac     2160

atggagagcg tggtggacgt gatcgagagc tgggacgagt ggccagacat cgaggaggac     2220

atcgccctga tcaagagcga ggagggcgag aagatggtgc tggagaacaa cttcttcgtg     2280

gagaccgtcc tgcccagcaa gatcatgaga aagctggagc ccgaggagtt cgccgcctac     2340

ctggagccct tcaaggagaa gggcgaggtg agaagaccca ccctgagctg gcccagagag     2400

atccccctgg tgaagggcgg caagcccgac gtggtgcaga tcgtgagaaa ctacaacgcc     2460

tacctgagag ccagcgacga cctgcccaag ctgttcatcg agagcgaccc cggcttcttc     2520

agcaacgcca tcgtggaggg cgccaagaag ttccccaaca ccgagttcgt gaaggtgaag     2580

ggcctgcact ttctccagga agacgccccc gacgagatgg gcaagtacat caagagcttc     2640

gtggagagag tgctgaagaa cgagcaaaca actttgtata ataaagttgc ctctggagga     2700

ggaggctctg gcatcgaata tggtgataag gagagaaagg ctgacgccaa gatggtgtgt     2760

gatgtggtga gtcggatgga agacaccgag cccttctctg cagagctgct ttctgccatg     2820

atgcggctct ggggcgactc aggaatccaa gagtgcttca accggtcccg ggagtatcag     2880

ctcaacgact ctgccaaata ctacctggac agcctggatc ggattggggc cgccgactac     2940

cagcccactg agcaggacat cctccgaacc agggtcaaaa ccactggcat cgtagaaacc     3000

cacttcacat tcaagaacct ccacttcagg ctgtttgacg tcggaggcca gcgatctgaa     3060

cgcaagaagt ggatccattg cttcgaggac gtcacggcca tcattttctg tgtcgcgctc     3120

agcggctatg accaggtgct ccacgaagac gaaaccacga accgcatgca cgagtctctc     3180

atgctcttcg actccatctg taacaacaag ttcttcatcg atacctccat cattctcttc     3240

ctcaacaaga aagatctctt tggcgagaag atcaagaagt cacctttgac catctgcttt     3300

cctgaataca caggccccaa tacctatgaa gacgcagccg cctacatcca agcacaattt     3360

gaaagcaaaa accgctcacc caacaaagaa atatattgtc acatgacttg tgccacagac     3420

acgaataaca tccaggtggt gttcgacgcc gtcaccgaca tcatcattgc caacaacctc     3480

cggggctgcg gcttgtactg a                                               3501


<210>  89
<211>  1166
<212>  PRT
<213>  Artificial

<220>
<223>  hM2R-Go[1-91]-L-Go(92-354) (RGLG-2) fusion protein

<400>  89

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg Ser Gly Gly Gly Gly Ser Met Gly Cys Thr Leu Ser Ala Glu 
465                 470                 475                 480 


Glu Arg Ala Ala Leu Glu Arg Ser Lys Ala Ile Glu Lys Asn Leu Lys 
                485                 490                 495     


Glu Asp Gly Ile Ser Ala Ala Lys Asp Val Lys Leu Leu Leu Leu Gly 
            500                 505                 510         


Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Lys Ile Ile 
        515                 520                 525             


His Glu Asp Gly Phe Ser Gly Glu Asp Val Lys Gln Tyr Lys Pro Val 
    530                 535                 540                 


Val Tyr Ser Asn Thr Ile Gln Ser Leu Ala Ala Ile Val Arg Ala Met 
545                 550                 555                 560 


Asp Thr Leu Ser Gly Gly Gly Gly Ser His Pro Thr Phe Leu Tyr Lys 
                565                 570                 575     


Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met 
            580                 585                 590         


Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu 
        595                 600                 605             


Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala 
    610                 615                 620                 


Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His 
625                 630                 635                 640 


Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu 
                645                 650                 655     


Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu 
            660                 665                 670         


Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu 
        675                 680                 685             


Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala 
    690                 695                 700                 


Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile Lys Ala Ile Val His 
705                 710                 715                 720 


Met Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp 
                725                 730                 735     


Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met 
            740                 745                 750         


Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile 
        755                 760                 765             


Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe 
    770                 775                 780                 


Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu 
785                 790                 795                 800 


Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg 
                805                 810                 815     


Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe 
            820                 825                 830         


Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala 
        835                 840                 845             


Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe 
    850                 855                 860                 


Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe 
865                 870                 875                 880 


Val Glu Arg Val Leu Lys Asn Glu Gln Thr Thr Leu Tyr Asn Lys Val 
                885                 890                 895     


Ala Ser Gly Gly Gly Gly Ser Gly Ile Glu Tyr Gly Asp Lys Glu Arg 
            900                 905                 910         


Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser Arg Met Glu Asp 
        915                 920                 925             


Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met Met Arg Leu Trp 
    930                 935                 940                 


Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser Arg Glu Tyr Gln 
945                 950                 955                 960 


Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu Asp Arg Ile Gly 
                965                 970                 975     


Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu Arg Thr Arg Val 
            980                 985                 990         


Lys Thr Thr Gly Ile Val Glu Thr  His Phe Thr Phe Lys  Asn Leu His 
        995                 1000                 1005             


Phe Arg  Leu Phe Asp Val Gly  Gly Gln Arg Ser Glu  Arg Lys Lys 
    1010                 1015                 1020             


Trp Ile  His Cys Phe Glu Asp  Val Thr Ala Ile Ile  Phe Cys Val 
    1025                 1030                 1035             


Ala Leu  Ser Gly Tyr Asp Gln  Val Leu His Glu Asp  Glu Thr Thr 
    1040                 1045                 1050             


Asn Arg  Met His Glu Ser Leu  Met Leu Phe Asp Ser  Ile Cys Asn 
    1055                 1060                 1065             


Asn Lys  Phe Phe Ile Asp Thr  Ser Ile Ile Leu Phe  Leu Asn Lys 
    1070                 1075                 1080             


Lys Asp  Leu Phe Gly Glu Lys  Ile Lys Lys Ser Pro  Leu Thr Ile 
    1085                 1090                 1095             


Cys Phe  Pro Glu Tyr Thr Gly  Pro Asn Thr Tyr Glu  Asp Ala Ala 
    1100                 1105                 1110             


Ala Tyr  Ile Gln Ala Gln Phe  Glu Ser Lys Asn Arg  Ser Pro Asn 
    1115                 1120                 1125             


Lys Glu  Ile Tyr Cys His Met  Thr Cys Ala Thr Asp  Thr Asn Asn 
    1130                 1135                 1140             


Ile Gln  Val Val Phe Asp Ala  Val Thr Asp Ile Ile  Ile Ala Asn 
    1145                 1150                 1155             


Asn Leu  Arg Gly Cys Gly Leu  Tyr 
    1160                 1165     


<210>  90
<211>  3195
<212>  DNA
<213>  Artificial

<220>
<223>  GHSR-L-G (RLG) fusion protein encoding DNA

<400>  90
atgtggaacg cgacgcccag cgaagagccg gggttcaacc tcacactggc cgacctggac       60

tgggatgctt cccccggcaa cgactcgctg ggcgacgagc tgctgcagct cttccccgcg      120

ccgctgctgg cgggcgtcac agccacctgc gtggcactct tcgtggtggg tatcgctggc      180

aacctgctca ccatgctggt ggtgtcgcgc ttccgcgagc tgcgcaccac caccaacctc      240

tacctgtcca gcatggcctt ctccgatctg ctcatcttcc tctgcatgcc cctggacctc      300

gttcgcctct ggcagtaccg gccctggaac ttcggcgacc tcctctgcaa actcttccaa      360

ttcgtcagtg agagctgcac ctacgccacg gtgctcacca tcacagcgct gagcgtcgag      420

cgctacttcg ccatctgctt cccactccgg gccaaggtgg tggtcaccaa ggggcgggtg      480

aagctggtca tcttcgtcat ctgggccgtg gccttctgca gcgccgggcc catcttcgtg      540

ctagtcgggg tggagcacga gaacggcacc gacccttggg acaccaacga gtgccgcccc      600

accgagtttg cggtgcgctc tggactgctc acggtcatgg tgtgggtgtc cagcatcttc      660

ttcttccttc ctgtcttctg tctcacggtc ctctacagtc tcatcggcag gaagctgtgg      720

cggaggaggc gcggcgatgc tgtcgtgggt gcctcgctca gggaccagaa ccacaagcaa      780

accgtgaaaa tgctggctgt agtggtgttt gccttcatcc tctgctggct ccccttccac      840

gtagggcgat atttattttc caaatccttt gagcctggct ccttggagat tgctcagatc      900

agccagtact gcaacctcgt gtcctttgtc ctcttctacc tcagtgctgc catcaacccc      960

attctgtaca acatcatgtc caagaagtac cgggtggcag tgttcagact tctgggattc     1020

gaacccttct cccagagaaa gctctccact ctgaaagatg aaagttctcg ggcctggaca     1080

gaatctagta ttaatacatc tggaggaggc ggatctcacc caacttttct atacaaagtt     1140

ggaatgacca gcaaggtgta cgaccccgag cagaggaaga ggatgatcac cggcccccag     1200

tggtgggcca ggtgcaagca gatgaacgtg ctggacagct tcatcaacta ctacgacagc     1260

gagaagcacg ccgagaacgc cgtgatcttc ctgcacggca acgccaccag cagctacctg     1320

tggaggcacg tggtgcccca catcgagccc gtggccaggt gcatcatccc cgatctgatc     1380

ggcatgggca agagcggcaa gagcggcaac ggcagctaca ggctgctgga ccactacaag     1440

tacctgaccg cctggttcga gctcctgaac ctgcccaaga agatcatctt cgtgggccac     1500

gactggggag ctgcactggc cttccactac gcctacgagc accaggacag aatcaaggcc     1560

atcgtgcaca tggagagcgt ggtggacgtg atcgagagct gggacgagtg gccagacatc     1620

gaggaggaca tcgccctgat caagagcgag gagggcgaga agatggtgct ggagaacaac     1680

ttcttcgtgg agaccgtcct gcccagcaag atcatgagaa agctggagcc cgaggagttc     1740

gccgcctacc tggagccctt caaggagaag ggcgaggtga gaagacccac cctgagctgg     1800

cccagagaga tccccctggt gaagggcggc aagcccgacg tggtgcagat cgtgagaaac     1860

tacaacgcct acctgagagc cagcgacgac ctgcccaagc tgttcatcga gagcgacccc     1920

ggcttcttca gcaacgccat cgtggagggc gccaagaagt tccccaacac cgagttcgtg     1980

aaggtgaagg gcctgcactt tctccaggaa gacgcccccg acgagatggg caagtacatc     2040

aagagcttcg tggagagagt gctgaagaac gagacaactt tgtataataa agttgcctct     2100

ggaggcggag gatctatgac tctggagtcc atcatggcgt gctgcctgag cgaggaggcc     2160

aaggaagccc ggcggatcaa cgacgagatc gagcggcagc tccgcaggga caagcgggac     2220

gcccgccggg agctcaagct gctgctgctc gggacaggag agagtggcaa gagtacgttt     2280

atcaagcaga tgagaatcat ccatgggtca ggatactctg atgaagataa aaggggcttc     2340

accaagctgg tgtatcagaa catcttcacg gccatgcagg ccatgatcag agccatggac     2400

acactcaaga tcccatacaa gtatgagcac aataaggctc atgcacaatt agttcgagaa     2460

gttgatgtgg agaaggtgtc tgcttttgag aatccatatg tagatgcaat aaagagttta     2520

tggaatgatc ctggaatcca ggaatgctat gatagacgac gagaatatca attatctgac     2580

tctaccaaat actatcttaa tgacttggac cgcgtagctg accctgccta cctgcctacg     2640

caacaagatg tgcttagagt tcgagtcccc accacaggga tcatcgaata cccctttgac     2700

ttacaaagtg tcattttcag aatggtcgat gtagggggcc aaaggtcaga gagaagaaaa     2760

tggatacact gctttgaaaa tgtcacctct atcatgtttc tagtagcgct tagtgaatat     2820

gatcaagttc tcgtggagtc agacaatgag aaccgaatgg aggaaagcaa ggctctcttt     2880

agaacaatta tcacataccc ctggttccag aactcctcgg ttattctgtt cttaaacaag     2940

aaagatcttc tagaggagaa aatcatgtat tcccatctag tcgactactt cccagaatat     3000

gatggacccc agagagatgc ccaggcagcc cgagaattca ttctgaagat gttcgtggac     3060

ctgaacccag acagtgacaa aattatctac tcccacttca cgtgcgccac agacaccgag     3120

aatatccgct ttgtctttgc tgccgtcaag gacaccatcc tccagttgaa cctgaaggag     3180

tacaatctgg tctaa                                                      3195


<210>  91
<211>  1064
<212>  PRT
<213>  Artificial

<220>
<223>  GHSR-L-G (RLG) fusion protein

<400>  91

Met Trp Asn Ala Thr Pro Ser Glu Glu Pro Gly Phe Asn Leu Thr Leu 
1               5                   10                  15      


Ala Asp Leu Asp Trp Asp Ala Ser Pro Gly Asn Asp Ser Leu Gly Asp 
            20                  25                  30          


Glu Leu Leu Gln Leu Phe Pro Ala Pro Leu Leu Ala Gly Val Thr Ala 
        35                  40                  45              


Thr Cys Val Ala Leu Phe Val Val Gly Ile Ala Gly Asn Leu Leu Thr 
    50                  55                  60                  


Met Leu Val Val Ser Arg Phe Arg Glu Leu Arg Thr Thr Thr Asn Leu 
65                  70                  75                  80  


Tyr Leu Ser Ser Met Ala Phe Ser Asp Leu Leu Ile Phe Leu Cys Met 
                85                  90                  95      


Pro Leu Asp Leu Val Arg Leu Trp Gln Tyr Arg Pro Trp Asn Phe Gly 
            100                 105                 110         


Asp Leu Leu Cys Lys Leu Phe Gln Phe Val Ser Glu Ser Cys Thr Tyr 
        115                 120                 125             


Ala Thr Val Leu Thr Ile Thr Ala Leu Ser Val Glu Arg Tyr Phe Ala 
    130                 135                 140                 


Ile Cys Phe Pro Leu Arg Ala Lys Val Val Val Thr Lys Gly Arg Val 
145                 150                 155                 160 


Lys Leu Val Ile Phe Val Ile Trp Ala Val Ala Phe Cys Ser Ala Gly 
                165                 170                 175     


Pro Ile Phe Val Leu Val Gly Val Glu His Glu Asn Gly Thr Asp Pro 
            180                 185                 190         


Trp Asp Thr Asn Glu Cys Arg Pro Thr Glu Phe Ala Val Arg Ser Gly 
        195                 200                 205             


Leu Leu Thr Val Met Val Trp Val Ser Ser Ile Phe Phe Phe Leu Pro 
    210                 215                 220                 


Val Phe Cys Leu Thr Val Leu Tyr Ser Leu Ile Gly Arg Lys Leu Trp 
225                 230                 235                 240 


Arg Arg Arg Arg Gly Asp Ala Val Val Gly Ala Ser Leu Arg Asp Gln 
                245                 250                 255     


Asn His Lys Gln Thr Val Lys Met Leu Ala Val Val Val Phe Ala Phe 
            260                 265                 270         


Ile Leu Cys Trp Leu Pro Phe His Val Gly Arg Tyr Leu Phe Ser Lys 
        275                 280                 285             


Ser Phe Glu Pro Gly Ser Leu Glu Ile Ala Gln Ile Ser Gln Tyr Cys 
    290                 295                 300                 


Asn Leu Val Ser Phe Val Leu Phe Tyr Leu Ser Ala Ala Ile Asn Pro 
305                 310                 315                 320 


Ile Leu Tyr Asn Ile Met Ser Lys Lys Tyr Arg Val Ala Val Phe Arg 
                325                 330                 335     


Leu Leu Gly Phe Glu Pro Phe Ser Gln Arg Lys Leu Ser Thr Leu Lys 
            340                 345                 350         


Asp Glu Ser Ser Arg Ala Trp Thr Glu Ser Ser Ile Asn Thr Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser His Pro Thr Phe Leu Tyr Lys Val Gly Met Thr Ser 
    370                 375                 380                 


Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln 
385                 390                 395                 400 


Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn 
                405                 410                 415     


Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His 
            420                 425                 430         


Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile 
        435                 440                 445             


Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys 
    450                 455                 460                 


Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys 
465                 470                 475                 480 


Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile 
                485                 490                 495     


Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr 
            500                 505                 510         


Glu His Gln Asp Arg Ile Lys Ala Ile Val His Met Glu Ser Val Val 
        515                 520                 525             


Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile 
    530                 535                 540                 


Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn 
545                 550                 555                 560 


Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu Glu 
                565                 570                 575     


Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu 
            580                 585                 590         


Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys 
        595                 600                 605             


Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr 
    610                 615                 620                 


Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro 
625                 630                 635                 640 


Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn 
                645                 650                 655     


Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Leu Gln Glu Asp Ala 
            660                 665                 670         


Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu 
        675                 680                 685             


Lys Asn Glu Thr Thr Leu Tyr Asn Lys Val Ala Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala 
705                 710                 715                 720 


Lys Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg 
                725                 730                 735     


Asp Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr 
            740                 745                 750         


Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His 
        755                 760                 765             


Gly Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val 
    770                 775                 780                 


Tyr Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp 
785                 790                 795                 800 


Thr Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln 
                805                 810                 815     


Leu Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro 
            820                 825                 830         


Tyr Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu 
        835                 840                 845             


Cys Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr 
    850                 855                 860                 


Tyr Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr 
865                 870                 875                 880 


Gln Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu 
                885                 890                 895     


Tyr Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly 
            900                 905                 910         


Gly Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val 
        915                 920                 925             


Thr Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu 
    930                 935                 940                 


Val Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe 
945                 950                 955                 960 


Arg Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu 
                965                 970                 975     


Phe Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His 
            980                 985                 990         


Leu Val Asp Tyr Phe Pro Glu Tyr  Asp Gly Pro Gln Arg  Asp Ala Gln 
        995                 1000                 1005             


Ala Ala  Arg Glu Phe Ile Leu  Lys Met Phe Val Asp  Leu Asn Pro 
    1010                 1015                 1020             


Asp Ser  Asp Lys Ile Ile Tyr  Ser His Phe Thr Cys  Ala Thr Asp 
    1025                 1030                 1035             


Thr Glu  Asn Ile Arg Phe Val  Phe Ala Ala Val Lys  Asp Thr Ile 
    1040                 1045                 1050             


Leu Gln  Leu Asn Leu Lys Glu  Tyr Asn Leu Val 
    1055                 1060                 


<210>  92
<211>  3825
<212>  DNA
<213>  Artificial

<220>
<223>  Glp2R-L-G (RLG) fusion protein encoding DNA

<400>  92
atgaagctgg gatcgagcag ggcagggcct gggagaggaa gcgcgggact cctgcctggc       60

gtccacgagc tgcccatggg catccctgcc ccctggggga ccagtcctct ctccttccac      120

aggaagtgct ctctctgggc ccctgggagg cccttcctca ctctggtcct gctggtttcc      180

atcaagcaag ttacaggatc cctccttgag gaaacgactc ggaagtgggc tcagtacaaa      240

caggcatgtc tgagagactt actcaaggaa ccttctggca tattttgtaa cgggacattt      300

gatcagtacg tgtgttggcc tcattcttct cctggaaatg tctctgtacc ctgcccttca      360

tacttacctt ggtggagtga agagagctca ggaagggcct acagacactg cttggctcag      420

gggacttggc agacgataga gaacgccacg gatatttggc aggatgactc cgaatgctcc      480

gagaaccaca gcttcaagca aaacgtggat cgttatgcct tgctgtcaac cttgcagctg      540

atgtacaccg tgggatactc cttctctctt atctccctct tcctggctct caccctcctc      600

ttgtttcttc gaaaactcca ctgcacgcgc aactacatcc acatgaactt gtttgcttct      660

ttcatcctga gaaccctggc tgtactggtg aaggacgtcg tcttctacaa ctcttactcc      720

aagaggcctg acaatgagaa tgggtggatg tcctacctgt cagagatgtc cacctcctgc      780

cgctcagtcc aggttctctt gcattacttt gtgggtgcca attacttatg gctgctggtc      840

gaaggcctct acctccacac gctgctggag cccacagtgc ttcctgagag gcggctgtgg      900

cccagatacc tgctgttggg ttgggccttc cctgtgctat ttgttgtacc ctggggtttc      960

gcccgtgcac acctggagaa cacagggtgc tggacaacaa atgggaataa gaaaatctgg     1020

tggatcatcc gaggacccat gatgctctgt gtaacagtca atttcttcat cttcctgaaa     1080

attctcaagc ttctcatttc taagctcaaa gctcatcaaa tgtgcttcag agattataaa     1140

tacagattgg caaaatcaac actggtcctc attcctttat tgggcgttca tgagatcctc     1200

ttctctttca tcactgatga tcaagttgaa ggatttgcaa aacttatacg acttttcatt     1260

cagttgacac tgagctcctt tcatgggttc ctggtggcct tgcagtatgg ttttgccaat     1320

ggagaggtga aggctgagct gcggaaatac tgggtccgct tcttgctagc ccgccactca     1380

ggctgcagag cctgtgtcct ggggaaggac ttccggttcc taggaaaatg tcccaagaag     1440

ctctcggaag gagatggcgc tgagaagctt cggaagctgc agccctcact taacagtggg     1500

cggctcctac atctagccat gcgaggtctt ggggagctgg gcgcccagcc ccaacaggac     1560

catgcacgct ggccccgggg cagcagcctg tccgagtgca gtgaggggga tgtcaccatg     1620

gccaacacca tggaggagat tctggaagag agtgagatcc acccaacttt tctatacaaa     1680

gttgccatga ccagcaaggt gtacgacccc gagcagagga agaggatgat caccggcccc     1740

cagtggtggg ccaggtgcaa gcagatgaac gtgctggaca gcttcatcaa ctactacgac     1800

agcgagaagc acgccgagaa cgccgtgatc ttcctgcacg gcaacgccac cagcagctac     1860

ctgtggaggc acgtggtgcc ccacatcgag cccgtggcca ggtgcatcat ccccgatctg     1920

atcggcatgg gcaagagcgg caagagcggc aacggcagct acaggctgct ggaccactac     1980

aagtacctga ccgcctggtt cgagctcctg aacctgccca agaagatcat cttcgtgggc     2040

cacgactggg gagctgcact ggccttccac tacgcctacg agcaccagga cagaatcaag     2100

gccatcgtgc acatggagag cgtggtggac gtgatcgaga gctgggacga gtggccagac     2160

atcgaggagg acatcgccct gatcaagagc gaggagggcg agaagatggt gctggagaac     2220

aacttcttcg tggagaccgt cctgcccagc aagatcatga gaaagctgga gcccgaggag     2280

ttcgccgcct acctggagcc cttcaaggag aagggcgagg tgagaagacc caccctgagc     2340

tggcccagag agatccccct ggtgaagggc ggcaagcccg acgtggtgca gatcgtgaga     2400

aactacaacg cctacctgag agccagcgac gacctgccca agctgttcat cgagagcgac     2460

cccggcttct tcagcaacgc catcgtggag ggcgccaaga agttccccaa caccgagttc     2520

gtgaaggtga agggcctgca ctttctccag gaagacgccc ccgacgagat gggcaagtac     2580

atcaagagct tcgtggagag agtgctgaag aacgagacaa ctttgtataa taaagttgcc     2640

atgggctgcc tcgggaacag taagaccgag gaccagcgca acgaggagaa ggcgcagcgt     2700

gaggccaaca aaaagatcga gaagcagctg cagaaggaca agcaggtcta ccgggccacg     2760

caccgcctgc tgctgctggg tgctggagaa tctggtaaaa gcaccattgt gaagcagatg     2820

aggatcctgc atgttaatgg gtttaatgga gagggcggcg aagaggaccc gcaggctgca     2880

aggagcaaca gcgatggtga gaaggcaacc aaagtgcagg acatcaaaaa caacctgaaa     2940

gaggcgattg aaaccattgt ggccgccatg agcaacctgg tgccccccgt ggagctggcc     3000

aaccccgaga accagttcag agtggactac attctgagtg tgatgaacgt gcctgacttt     3060

gacttccctc ccgaattcta tgagcatgcc aaggctctgt gggaggatga aggagtgcgt     3120

gcctgctacg aacgctccaa cgagtaccag ctgattgact gtgcccagta cttcctggac     3180

aagatcgacg tgatcaagca ggctgactat gtgccgagcg atcaggacct gcttcgctgc     3240

cgtgtcctga cttctggaat ctttgagacc aagttccagg tggacaaagt caacttccac     3300

atgtttgacg tgggtggcca gcgcgatgaa cgccgcaagt ggatccagtg cttcaacgat     3360

gtgactgcca tcatcttcgt ggtggccagc agcagctaca acatggtcat ccgggaggac     3420

aaccagacca accgcctgca ggaggctctg aacctcttca agagcatctg gaacaacaga     3480

tggctgcgca ccatctctgt gatcctgttc ctcaacaagc aagatctgct cgctgagaaa     3540

gtccttgctg ggaaatcgaa gattgaggac tactttccag aatttgctcg ctacactact     3600

cctgaggatg ctactcccga gcccggagag gacccacgcg tgacccgggc caagtacttc     3660

attcgagatg agtttctgag gatcagcact gccagtggag atgggcgtca ctactgctac     3720

cctcatttca cctgcgctgt ggacactgag aacatccgcc gtgtgttcaa cgactgccgt     3780

gacatcattc agcgcatgca ccttcgtcag tacgagctgc tctaa                     3825


<210>  93
<211>  1274
<212>  PRT
<213>  Artificial

<220>
<223>  Glp2R-L-G (RLG) fusion protein

<400>  93

Met Lys Leu Gly Ser Ser Arg Ala Gly Pro Gly Arg Gly Ser Ala Gly 
1               5                   10                  15      


Leu Leu Pro Gly Val His Glu Leu Pro Met Gly Ile Pro Ala Pro Trp 
            20                  25                  30          


Gly Thr Ser Pro Leu Ser Phe His Arg Lys Cys Ser Leu Trp Ala Pro 
        35                  40                  45              


Gly Arg Pro Phe Leu Thr Leu Val Leu Leu Val Ser Ile Lys Gln Val 
    50                  55                  60                  


Thr Gly Ser Leu Leu Glu Glu Thr Thr Arg Lys Trp Ala Gln Tyr Lys 
65                  70                  75                  80  


Gln Ala Cys Leu Arg Asp Leu Leu Lys Glu Pro Ser Gly Ile Phe Cys 
                85                  90                  95      


Asn Gly Thr Phe Asp Gln Tyr Val Cys Trp Pro His Ser Ser Pro Gly 
            100                 105                 110         


Asn Val Ser Val Pro Cys Pro Ser Tyr Leu Pro Trp Trp Ser Glu Glu 
        115                 120                 125             


Ser Ser Gly Arg Ala Tyr Arg His Cys Leu Ala Gln Gly Thr Trp Gln 
    130                 135                 140                 


Thr Ile Glu Asn Ala Thr Asp Ile Trp Gln Asp Asp Ser Glu Cys Ser 
145                 150                 155                 160 


Glu Asn His Ser Phe Lys Gln Asn Val Asp Arg Tyr Ala Leu Leu Ser 
                165                 170                 175     


Thr Leu Gln Leu Met Tyr Thr Val Gly Tyr Ser Phe Ser Leu Ile Ser 
            180                 185                 190         


Leu Phe Leu Ala Leu Thr Leu Leu Leu Phe Leu Arg Lys Leu His Cys 
        195                 200                 205             


Thr Arg Asn Tyr Ile His Met Asn Leu Phe Ala Ser Phe Ile Leu Arg 
    210                 215                 220                 


Thr Leu Ala Val Leu Val Lys Asp Val Val Phe Tyr Asn Ser Tyr Ser 
225                 230                 235                 240 


Lys Arg Pro Asp Asn Glu Asn Gly Trp Met Ser Tyr Leu Ser Glu Met 
                245                 250                 255     


Ser Thr Ser Cys Arg Ser Val Gln Val Leu Leu His Tyr Phe Val Gly 
            260                 265                 270         


Ala Asn Tyr Leu Trp Leu Leu Val Glu Gly Leu Tyr Leu His Thr Leu 
        275                 280                 285             


Leu Glu Pro Thr Val Leu Pro Glu Arg Arg Leu Trp Pro Arg Tyr Leu 
    290                 295                 300                 


Leu Leu Gly Trp Ala Phe Pro Val Leu Phe Val Val Pro Trp Gly Phe 
305                 310                 315                 320 


Ala Arg Ala His Leu Glu Asn Thr Gly Cys Trp Thr Thr Asn Gly Asn 
                325                 330                 335     


Lys Lys Ile Trp Trp Ile Ile Arg Gly Pro Met Met Leu Cys Val Thr 
            340                 345                 350         


Val Asn Phe Phe Ile Phe Leu Lys Ile Leu Lys Leu Leu Ile Ser Lys 
        355                 360                 365             


Leu Lys Ala His Gln Met Cys Phe Arg Asp Tyr Lys Tyr Arg Leu Ala 
    370                 375                 380                 


Lys Ser Thr Leu Val Leu Ile Pro Leu Leu Gly Val His Glu Ile Leu 
385                 390                 395                 400 


Phe Ser Phe Ile Thr Asp Asp Gln Val Glu Gly Phe Ala Lys Leu Ile 
                405                 410                 415     


Arg Leu Phe Ile Gln Leu Thr Leu Ser Ser Phe His Gly Phe Leu Val 
            420                 425                 430         


Ala Leu Gln Tyr Gly Phe Ala Asn Gly Glu Val Lys Ala Glu Leu Arg 
        435                 440                 445             


Lys Tyr Trp Val Arg Phe Leu Leu Ala Arg His Ser Gly Cys Arg Ala 
    450                 455                 460                 


Cys Val Leu Gly Lys Asp Phe Arg Phe Leu Gly Lys Cys Pro Lys Lys 
465                 470                 475                 480 


Leu Ser Glu Gly Asp Gly Ala Glu Lys Leu Arg Lys Leu Gln Pro Ser 
                485                 490                 495     


Leu Asn Ser Gly Arg Leu Leu His Leu Ala Met Arg Gly Leu Gly Glu 
            500                 505                 510         


Leu Gly Ala Gln Pro Gln Gln Asp His Ala Arg Trp Pro Arg Gly Ser 
        515                 520                 525             


Ser Leu Ser Glu Cys Ser Glu Gly Asp Val Thr Met Ala Asn Thr Met 
    530                 535                 540                 


Glu Glu Ile Leu Glu Glu Ser Glu Ile His Pro Thr Phe Leu Tyr Lys 
545                 550                 555                 560 


Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met 
                565                 570                 575     


Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu 
            580                 585                 590         


Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala 
        595                 600                 605             


Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser Tyr Leu Trp Arg His 
    610                 615                 620                 


Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu 
625                 630                 635                 640 


Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu 
                645                 650                 655     


Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu 
            660                 665                 670         


Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala 
        675                 680                 685             


Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile Lys Ala Ile Val His 
    690                 695                 700                 


Met Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp 
705                 710                 715                 720 


Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met 
                725                 730                 735     


Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile 
            740                 745                 750         


Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe 
        755                 760                 765             


Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu 
    770                 775                 780                 


Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg 
785                 790                 795                 800 


Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Leu Phe 
                805                 810                 815     


Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala 
            820                 825                 830         


Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe 
        835                 840                 845             


Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe 
    850                 855                 860                 


Val Glu Arg Val Leu Lys Asn Glu Thr Thr Leu Tyr Asn Lys Val Ala 
865                 870                 875                 880 


Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
                885                 890                 895     


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            900                 905                 910         


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        915                 920                 925             


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    930                 935                 940                 


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
945                 950                 955                 960 


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                965                 970                 975     


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            980                 985                 990         


Leu Val Pro Pro Val Glu Leu Ala  Asn Pro Glu Asn Gln  Phe Arg Val 
        995                 1000                 1005             


Asp Tyr  Ile Leu Ser Val Met  Asn Val Pro Asp Phe  Asp Phe Pro 
    1010                 1015                 1020             


Pro Glu  Phe Tyr Glu His Ala  Lys Ala Leu Trp Glu  Asp Glu Gly 
    1025                 1030                 1035             


Val Arg  Ala Cys Tyr Glu Arg  Ser Asn Glu Tyr Gln  Leu Ile Asp 
    1040                 1045                 1050             


Cys Ala  Gln Tyr Phe Leu Asp  Lys Ile Asp Val Ile  Lys Gln Ala 
    1055                 1060                 1065             


Asp Tyr  Val Pro Ser Asp Gln  Asp Leu Leu Arg Cys  Arg Val Leu 
    1070                 1075                 1080             


Thr Ser  Gly Ile Phe Glu Thr  Lys Phe Gln Val Asp  Lys Val Asn 
    1085                 1090                 1095             


Phe His  Met Phe Asp Val Gly  Gly Gln Arg Asp Glu  Arg Arg Lys 
    1100                 1105                 1110             


Trp Ile  Gln Cys Phe Asn Asp  Val Thr Ala Ile Ile  Phe Val Val 
    1115                 1120                 1125             


Ala Ser  Ser Ser Tyr Asn Met  Val Ile Arg Glu Asp  Asn Gln Thr 
    1130                 1135                 1140             


Asn Arg  Leu Gln Glu Ala Leu  Asn Leu Phe Lys Ser  Ile Trp Asn 
    1145                 1150                 1155             


Asn Arg  Trp Leu Arg Thr Ile  Ser Val Ile Leu Phe  Leu Asn Lys 
    1160                 1165                 1170             


Gln Asp  Leu Leu Ala Glu Lys  Val Leu Ala Gly Lys  Ser Lys Ile 
    1175                 1180                 1185             


Glu Asp  Tyr Phe Pro Glu Phe  Ala Arg Tyr Thr Thr  Pro Glu Asp 
    1190                 1195                 1200             


Ala Thr  Pro Glu Pro Gly Glu  Asp Pro Arg Val Thr  Arg Ala Lys 
    1205                 1210                 1215             


Tyr Phe  Ile Arg Asp Glu Phe  Leu Arg Ile Ser Thr  Ala Ser Gly 
    1220                 1225                 1230             


Asp Gly  Arg His Tyr Cys Tyr  Pro His Phe Thr Cys  Ala Val Asp 
    1235                 1240                 1245             


Thr Glu  Asn Ile Arg Arg Val  Phe Asn Asp Cys Arg  Asp Ile Ile 
    1250                 1255                 1260             


Gln Arg  Met His Leu Arg Gln  Tyr Glu Leu Leu 
    1265                 1270                 


<210>  94
<211>  3597
<212>  DNA
<213>  Artificial

<220>
<223>  GlucR-L-G (RLG) fusion protein encoding DNA

<400>  94
atgcccccct gccagccaca gcgacccctg ctgctgttgc tgctgctgct ggcctgccag       60

ccacaggtcc cctccgctca ggtgatggac ttcctgtttg agaagtggaa gctctacggt      120

gaccagtgtc accacaacct gagcctgctg ccccctccca cggagctggt gtgcaacaga      180

accttcgaca agtattcctg ctggccggac acccccgcca ataccacggc caacatctcc      240

tgcccctggt acctgccttg gcaccacaaa gtgcaacacc gcttcgtgtt caagagatgc      300

gggcccgacg gtcagtgggt gcgtggaccc cgggggcagc cttggcgtga tgcctcccag      360

tgccagatgg atggcgagga gattgaggtc cagaaggagg tggccaagat gtacagcagc      420

ttccaggtga tgtacacagt gggctacagc ctgtccctgg gggccctgct cctcgccttg      480

gccatcctgg ggggcctcag caagctgcac tgcacccgca atgccatcca cgcgaatctg      540

tttgcgtcct tcgtgctgaa agccagctcc gtgctggtca ttgatgggct gctcaggacc      600

cgctacagcc agaaaattgg cgacgacctc agtgtcagca cctggctcag tgatggagcg      660

gtggctggct gccgtgtggc cgcggtgttc atgcaatatg gcatcgtggc caactactgc      720

tggctgctgg tggagggcct gtacctgcac aacctgctgg gcctggccac cctccccgag      780

aggagcttct tcagcctcta cctgggcatc ggctggggtg cccccatgct gttcgtcgtc      840

ccctgggcag tggtcaagtg tctgttcgag aacgtccagt gctggaccag caatgacaac      900

atgggcttct ggtggatcct gcggttcccc gtcttcctgg ccatcctgat caacttcttc      960

atcttcgtcc gcatcgttca gctgctcgtg gccaagctgc gggcacggca gatgcaccac     1020

acagactaca agttccggct ggccaagtcc acgctgaccc tcatccctct gctgggcgtc     1080

cacgaagtgg tcttcgcctt cgtgacggac gagcacgccc agggcaccct gcgctccgcc     1140

aagctcttct tcgacctctt cctcagctcc ttccagggcc tgctggtggc tgtcctctac     1200

tgcttcctca acaaggaggt gcagtcggag ctgcggcggc gttggcaccg ctggcgcctg     1260

ggcaaagtgc tatgggagga gcggaacacc agcaaccaca gggcctcatc ttcgcccggc     1320

cacggccctc ccagcaagga gctgcagttt gggaggggtg gtggcagcca ggattcatct     1380

gcggagaccc ccttggctgg tggcctccct agattggctg agagcccctt ccacccaact     1440

tttctataca aagttgccat gaccagcaag gtgtacgacc ccgagcagag gaagaggatg     1500

atcaccggcc cccagtggtg ggccaggtgc aagcagatga acgtgctgga cagcttcatc     1560

aactactacg acagcgagaa gcacgccgag aacgccgtga tcttcctgca cggcaacgcc     1620

accagcagct acctgtggag gcacgtggtg ccccacatcg agcccgtggc caggtgcatc     1680

atccccgatc tgatcggcat gggcaagagc ggcaagagcg gcaacggcag ctacaggctg     1740

ctggaccact acaagtacct gaccgcctgg ttcgagctcc tgaacctgcc caagaagatc     1800

atcttcgtgg gccacgactg gggagctgca ctggccttcc actacgccta cgagcaccag     1860

gacagaatca aggccatcgt gcacatggag agcgtggtgg acgtgatcga gagctgggac     1920

gagtggccag acatcgagga ggacatcgcc ctgatcaaga gcgaggaggg cgagaagatg     1980

gtgctggaga acaacttctt cgtggagacc gtcctgccca gcaagatcat gagaaagctg     2040

gagcccgagg agttcgccgc ctacctggag cccttcaagg agaagggcga ggtgagaaga     2100

cccaccctga gctggcccag agagatcccc ctggtgaagg gcggcaagcc cgacgtggtg     2160

cagatcgtga gaaactacaa cgcctacctg agagccagcg acgacctgcc caagctgttc     2220

atcgagagcg accccggctt cttcagcaac gccatcgtgg agggcgccaa gaagttcccc     2280

aacaccgagt tcgtgaaggt gaagggcctg cactttctcc aggaagacgc ccccgacgag     2340

atgggcaagt acatcaagag cttcgtggag agagtgctga agaacgagac aactttgtat     2400

aataaagttg ccatgggctg cctcgggaac agtaagaccg aggaccagcg caacgaggag     2460

aaggcgcagc gtgaggccaa caaaaagatc gagaagcagc tgcagaagga caagcaggtc     2520

taccgggcca cgcaccgcct gctgctgctg ggtgctggag aatctggtaa aagcaccatt     2580

gtgaagcaga tgaggatcct gcatgttaat gggtttaatg gagagggcgg cgaagaggac     2640

ccgcaggctg caaggagcaa cagcgatggt gagaaggcaa ccaaagtgca ggacatcaaa     2700

aacaacctga aagaggcgat tgaaaccatt gtggccgcca tgagcaacct ggtgcccccc     2760

gtggagctgg ccaaccccga gaaccagttc agagtggact acattctgag tgtgatgaac     2820

gtgcctgact ttgacttccc tcccgaattc tatgagcatg ccaaggctct gtgggaggat     2880

gaaggagtgc gtgcctgcta cgaacgctcc aacgagtacc agctgattga ctgtgcccag     2940

tacttcctgg acaagatcga cgtgatcaag caggctgact atgtgccgag cgatcaggac     3000

ctgcttcgct gccgtgtcct gacttctgga atctttgaga ccaagttcca ggtggacaaa     3060

gtcaacttcc acatgtttga cgtgggtggc cagcgcgatg aacgccgcaa gtggatccag     3120

tgcttcaacg atgtgactgc catcatcttc gtggtggcca gcagcagcta caacatggtc     3180

atccgggagg acaaccagac caaccgcctg caggaggctc tgaacctctt caagagcatc     3240

tggaacaaca gatggctgcg caccatctct gtgatcctgt tcctcaacaa gcaagatctg     3300

ctcgctgaga aagtccttgc tgggaaatcg aagattgagg actactttcc agaatttgct     3360

cgctacacta ctcctgagga tgctactccc gagcccggag aggacccacg cgtgacccgg     3420

gccaagtact tcattcgaga tgagtttctg aggatcagca ctgccagtgg agatgggcgt     3480

cactactgct accctcattt cacctgcgct gtggacactg agaacatccg ccgtgtgttc     3540

aacgactgcc gtgacatcat tcagcgcatg caccttcgtc agtacgagct gctctaa        3597


<210>  95
<211>  1198
<212>  PRT
<213>  Artificial

<220>
<223>  GlucR-L-G (RLG) fusion protein

<400>  95

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 


Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 


Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     


Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         


Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             


Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 


Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 


Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     


Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         


Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             


Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 


Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     


Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         


His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             


Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 


Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe His Pro Thr 
465                 470                 475                 480 


Phe Leu Tyr Lys Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu Gln 
                485                 490                 495     


Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln 
            500                 505                 510         


Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His 
        515                 520                 525             


Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser Tyr 
    530                 535                 540                 


Leu Trp Arg His Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile 
545                 550                 555                 560 


Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly 
                565                 570                 575     


Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu 
            580                 585                 590         


Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly 
        595                 600                 605             


Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile Lys 
    610                 615                 620                 


Ala Ile Val His Met Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp 
625                 630                 635                 640 


Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu 
                645                 650                 655     


Gly Glu Lys Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu 
            660                 665                 670         


Pro Ser Lys Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr 
        675                 680                 685             


Leu Glu Pro Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser 
    690                 695                 700                 


Trp Pro Arg Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val 
705                 710                 715                 720 


Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu 
                725                 730                 735     


Pro Lys Leu Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile 
            740                 745                 750         


Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys 
        755                 760                 765             


Gly Leu His Phe Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr 
    770                 775                 780                 


Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn Glu Thr Thr Leu Tyr 
785                 790                 795                 800 


Asn Lys Val Ala Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln 
                805                 810                 815     


Arg Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys 
            820                 825                 830         


Gln Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu 
        835                 840                 845             


Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met 
    850                 855                 860                 


Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp 
865                 870                 875                 880 


Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val 
                885                 890                 895     


Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala 
            900                 905                 910         


Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn 
        915                 920                 925             


Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe 
    930                 935                 940                 


Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp 
945                 950                 955                 960 


Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile 
                965                 970                 975     


Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala 
            980                 985                 990         


Asp Tyr Val Pro Ser Asp Gln Asp  Leu Leu Arg Cys Arg  Val Leu Thr 
        995                 1000                 1005             


Ser Gly  Ile Phe Glu Thr Lys  Phe Gln Val Asp Lys  Val Asn Phe 
    1010                 1015                 1020             


His Met  Phe Asp Val Gly Gly  Gln Arg Asp Glu Arg  Arg Lys Trp 
    1025                 1030                 1035             


Ile Gln  Cys Phe Asn Asp Val  Thr Ala Ile Ile Phe  Val Val Ala 
    1040                 1045                 1050             


Ser Ser  Ser Tyr Asn Met Val  Ile Arg Glu Asp Asn  Gln Thr Asn 
    1055                 1060                 1065             


Arg Leu  Gln Glu Ala Leu Asn  Leu Phe Lys Ser Ile  Trp Asn Asn 
    1070                 1075                 1080             


Arg Trp  Leu Arg Thr Ile Ser  Val Ile Leu Phe Leu  Asn Lys Gln 
    1085                 1090                 1095             


Asp Leu  Leu Ala Glu Lys Val  Leu Ala Gly Lys Ser  Lys Ile Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Pro Glu Phe Ala  Arg Tyr Thr Thr Pro  Glu Asp Ala 
    1115                 1120                 1125             


Thr Pro  Glu Pro Gly Glu Asp  Pro Arg Val Thr Arg  Ala Lys Tyr 
    1130                 1135                 1140             


Phe Ile  Arg Asp Glu Phe Leu  Arg Ile Ser Thr Ala  Ser Gly Asp 
    1145                 1150                 1155             


Gly Arg  His Tyr Cys Tyr Pro  His Phe Thr Cys Ala  Val Asp Thr 
    1160                 1165                 1170             


Glu Asn  Ile Arg Arg Val Phe  Asn Asp Cys Arg Asp  Ile Ile Gln 
    1175                 1180                 1185             


Arg Met  His Leu Arg Gln Tyr  Glu Leu Leu 
    1190                 1195             


<210>  96
<211>  4719
<212>  DNA
<213>  Artificial

<220>
<223>  hmGluR2-Go[1-91]-L-Go(92-354) (RGLG-2) fusion protein encoding 
       DNA

<400>  96
atgggatcgc tgcttgcgct cctggcactg ctgctgctgt ggggtgctgt ggctgagggc       60

ccagccaaga aggtgctgac cctggaggga gacttggtgc tgggtgggct gttcccagtg      120

caccagaagg gcggcccagc agaggactgt ggtcctgtca atgagcaccg tggcatccag      180

cgcctggagg ccatgctttt tgcactggac cgcatcaacc gtgacccgca cctgctgcct      240

ggcgtgcgcc tgggtgcaca catcctcgac agttgctcca aggacacaca tgcgctggag      300

caggcactgg actttgtgcg tgcctcactc agccgtggtg ctgatggctc acgccacatc      360

tgccccgacg gctcttatgc gacccatggt gatgctccca ctgccatcac tggtgttatt      420

ggcggttcct acagtgatgt ctccatccag gtggccaacc tcttgaggct atttcagatc      480

ccacagatta gctacgcctc taccagtgcc aagctgagtg acaagtcccg ctatgactac      540

tttgcccgca cagtgcctcc tgacttcttc caagccaagg ccatggctga gattctccgc      600

ttcttcaact ggacctatgt gtccactgtg gcgtctgagg gcgactatgg cgagacaggc      660

attgaggcct ttgagctaga ggctcgtgcc cgcaacatct gtgtggccac ctcggagaaa      720

gtgggccgtg ccatgagccg cgcggccttt gagggtgtgg tgcgagccct gctgcagaag      780

cccagtgccc gcgtggctgt cctgttcacc cgttctgagg atgcccggga gctgcttgct      840

gccagccagc gcctcaatgc cagcttcacc tgggtggcca gtgatggttg gggggccctg      900

gagagtgtgg tggcaggcag tgagggggct gctgagggtg ctatcaccat cgagctggcc      960

tcctacccca tcagtgactt tgcctcctac ttccagagcc tggacccttg gaacaacagc     1020

cggaacccct ggttccgtga attctgggag cagaggttcc gctgcagctt ccggcagcga     1080

gactgcgcag cccactctct ccgggctgtg ccctttgagc aggagtccaa gatcatgttt     1140

gtggtcaatg cagtgtacgc catggcccat gcgctccaca acatgcaccg tgccctctgc     1200

cccaacacca cccggctctg tgacgcgatg cggccagtta acgggcgccg cctctacaag     1260

gactttgtgc tcaacgtcaa gtttgatgcc ccctttcgcc cagctgacac ccacaatgag     1320

gtccgctttg accgctttgg tgatggtatt ggccgctaca acatcttcac ctatctgcgt     1380

gcaggcagtg ggcgctatcg ctaccagaag gtgggctact gggcagaagg cttgactctg     1440

gacaccagcc tcatcccatg ggcctcaccc tcagccggcc ccctgcccgc ctctcgctgc     1500

agtgagccct gcctccagaa tgaggtgaag agtgtgcagc cgggcgaagt ctgctgctgg     1560

ctctgcattc cgtgccagcc ctatgagtac cgattggacg aattcacttg cgctgattgt     1620

ggcctgggct actggcccaa tgccagcctg actggctgct tcgaactgcc ccaggagtac     1680

atccgctggg gcgatgcctg ggctgtggga cctgtcacca tcgcctgcct cggtgccctg     1740

gccaccctct ttgtgctggg tgtctttgtg cggcacaatg ccacaccagt ggtcaaggcc     1800

tcaggtcggg agctctgcta catcctgctg ggtggtgtct tcctctgcta ctgcatgacc     1860

ttcatcttca ttgccaagcc atccacggca gtgtgtacct tacggcgtct tggtttgggc     1920

actgccttct ctgtctgcta ctcagccctg ctcaccaaga ccaaccgcat tgcacgcatc     1980

ttcggtgggg cccgggaggg tgcccagcgg ccacgcttca tcagtcctgc ctcacaggtg     2040

gccatctgcc tggcacttat ctcgggccag ctgctcatcg tggtcgcctg gctggtggtg     2100

gaggcaccgg gcacaggcaa ggagacagcc cccgaacggc gggaggtggt gacactgcgc     2160

tgcaaccacc gcgatgcaag tatgttgggc tcgctggcct acaatgtgct cctcatcgcg     2220

ctctgcacgc tttatgcctt caagactcgc aagtgccccg aaaacttcaa cgaggccaag     2280

ttcattggct tcaccatgta caccacctgc atcatctggc tggcattcct gcccatcttc     2340

tatgtcacct ccagtgacta ccgggtacag accaccacca tgtgcgtgtc agtcagcctc     2400

agcggctccg tggtgcttgg ctgcctcttt gcgcccaagc tgcacatcat cctcttccag     2460

ccgcagaaga acgtggttag ccaccgggca cccaccagcc gctttggcag tgctgctgcc     2520

agggccagct ccagccttgg ccaagggtct ggctcccagt ttgtccccac tgtttgcaat     2580

ggccgtgagg tggtggactc gacaacgtca tcgctttctg gaggcggagg atctatggga     2640

tgtactctga gcgcagagga gagagccgcc ctcgagcgga gcaaggcgat tgagaaaaac     2700

ctcaaagagg atggcatcag cgccgccaaa gacgtgaaat tactcctgct cggggctgga     2760

gaatcaggaa aaagcaccat tgtgaagcag atgaagatca tccatgaaga tggcttctcc     2820

ggagaagacg tgaaacagta caagcctgtt gtctacagca acactatcca gtccctggca     2880

gccatcgtcc gggccatgga cactttgtct ggaggaggcg gatctcaccc aacttttcta     2940

tacaaagttg ccatgaccag caaggtgtac gaccccgagc agaggaagag gatgatcacc     3000

ggcccccagt ggtgggccag gtgcaagcag atgaacgtgc tggacagctt catcaactac     3060

tacgacagcg agaagcacgc cgagaacgcc gtgatcttcc tgcacggcaa cgccaccagc     3120

agctacctgt ggaggcacgt ggtgccccac atcgagcccg tggccaggtg catcatcccc     3180

gatctgatcg gcatgggcaa gagcggcaag agcggcaacg gcagctacag gctgctggac     3240

cactacaagt acctgaccgc ctggttcgag ctcctgaacc tgcccaagaa gatcatcttc     3300

gtgggccacg actggggagc tgcactggcc ttccactacg cctacgagca ccaggacaga     3360

atcaaggcca tcgtgcacat ggagagcgtg gtggacgtga tcgagagctg ggacgagtgg     3420

ccagacatcg aggaggacat cgccctgatc aagagcgagg agggcgagaa gatggtgctg     3480

gagaacaact tcttcgtgga gaccgtcctg cccagcaaga tcatgagaaa gctggagccc     3540

gaggagttcg ccgcctacct ggagcccttc aaggagaagg gcgaggtgag aagacccacc     3600

ctgagctggc ccagagagat ccccctggtg aagggcggca agcccgacgt ggtgcagatc     3660

gtgagaaact acaacgccta cctgagagcc agcgacgacc tgcccaagct gttcatcgag     3720

agcgaccccg gcttcttcag caacgccatc gtggagggcg ccaagaagtt ccccaacacc     3780

gagttcgtga aggtgaaggg cctgcacttt ctccaggaag acgcccccga cgagatgggc     3840

aagtacatca agagcttcgt ggagagagtg ctgaagaacg agcaaacaac tttgtataat     3900

aaagttgcct ctggaggagg aggctctggc atcgaatatg gtgataagga gagaaaggct     3960

gacgccaaga tggtgtgtga tgtggtgagt cggatggaag acaccgagcc cttctctgca     4020

gagctgcttt ctgccatgat gcggctctgg ggcgactcag gaatccaaga gtgcttcaac     4080

cggtcccggg agtatcagct caacgactct gccaaatact acctggacag cctggatcgg     4140

attggggccg ccgactacca gcccactgag caggacatcc tccgaaccag ggtcaaaacc     4200

actggcatcg tagaaaccca cttcacattc aagaacctcc acttcaggct gtttgacgtc     4260

ggaggccagc gatctgaacg caagaagtgg atccattgct tcgaggacgt cacggccatc     4320

attttctgtg tcgcgctcag cggctatgac caggtgctcc acgaagacga aaccacgaac     4380

cgcatgcacg agtctctcat gctcttcgac tccatctgta acaacaagtt cttcatcgat     4440

acctccatca ttctcttcct caacaagaaa gatctctttg gcgagaagat caagaagtca     4500

cctttgacca tctgctttcc tgaatacaca ggccccaata cctatgaaga cgcagccgcc     4560

tacatccaag cacaatttga aagcaaaaac cgctcaccca acaaagaaat atattgtcac     4620

atgacttgtg ccacagacac gaataacatc caggtggtgt tcgacgccgt caccgacatc     4680

atcattgcca acaacctccg gggctgcggc ttgtactga                            4719


<210>  97
<211>  1572
<212>  PRT
<213>  Artificial

<220>
<223>  hmGluR2-Go[1-91]-L-Go(92-354) (RGLG-2) fusion protein

<400>  97

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Val Gly Tyr Trp Ala Glu Gly Leu Thr Leu 
465                 470                 475                 480 


Asp Thr Ser Leu Ile Pro Trp Ala Ser Pro Ser Ala Gly Pro Leu Pro 
                485                 490                 495     


Ala Ser Arg Cys Ser Glu Pro Cys Leu Gln Asn Glu Val Lys Ser Val 
            500                 505                 510         


Gln Pro Gly Glu Val Cys Cys Trp Leu Cys Ile Pro Cys Gln Pro Tyr 
        515                 520                 525             


Glu Tyr Arg Leu Asp Glu Phe Thr Cys Ala Asp Cys Gly Leu Gly Tyr 
    530                 535                 540                 


Trp Pro Asn Ala Ser Leu Thr Gly Cys Phe Glu Leu Pro Gln Glu Tyr 
545                 550                 555                 560 


Ile Arg Trp Gly Asp Ala Trp Ala Val Gly Pro Val Thr Ile Ala Cys 
                565                 570                 575     


Leu Gly Ala Leu Ala Thr Leu Phe Val Leu Gly Val Phe Val Arg His 
            580                 585                 590         


Asn Ala Thr Pro Val Val Lys Ala Ser Gly Arg Glu Leu Cys Tyr Ile 
        595                 600                 605             


Leu Leu Gly Gly Val Phe Leu Cys Tyr Cys Met Thr Phe Ile Phe Ile 
    610                 615                 620                 


Ala Lys Pro Ser Thr Ala Val Cys Thr Leu Arg Arg Leu Gly Leu Gly 
625                 630                 635                 640 


Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg 
                645                 650                 655     


Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu Gly Ala Gln Arg Pro Arg 
            660                 665                 670         


Phe Ile Ser Pro Ala Ser Gln Val Ala Ile Cys Leu Ala Leu Ile Ser 
        675                 680                 685             


Gly Gln Leu Leu Ile Val Val Ala Trp Leu Val Val Glu Ala Pro Gly 
    690                 695                 700                 


Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg Glu Val Val Thr Leu Arg 
705                 710                 715                 720 


Cys Asn His Arg Asp Ala Ser Met Leu Gly Ser Leu Ala Tyr Asn Val 
                725                 730                 735     


Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala Phe Lys Thr Arg Lys Cys 
            740                 745                 750         


Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr 
        755                 760                 765             


Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser 
    770                 775                 780                 


Ser Asp Tyr Arg Val Gln Thr Thr Thr Met Cys Val Ser Val Ser Leu 
785                 790                 795                 800 


Ser Gly Ser Val Val Leu Gly Cys Leu Phe Ala Pro Lys Leu His Ile 
                805                 810                 815     


Ile Leu Phe Gln Pro Gln Lys Asn Val Val Ser His Arg Ala Pro Thr 
            820                 825                 830         


Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln 
        835                 840                 845             


Gly Ser Gly Ser Gln Phe Val Pro Thr Val Cys Asn Gly Arg Glu Val 
    850                 855                 860                 


Val Asp Ser Thr Thr Ser Ser Leu Ser Gly Gly Gly Gly Ser Met Gly 
865                 870                 875                 880 


Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser Lys Ala 
                885                 890                 895     


Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys Asp Val 
            900                 905                 910         


Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val 
        915                 920                 925             


Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu Asp Val 
    930                 935                 940                 


Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser Leu Ala 
945                 950                 955                 960 


Ala Ile Val Arg Ala Met Asp Thr Leu Ser Gly Gly Gly Gly Ser His 
                965                 970                 975     


Pro Thr Phe Leu Tyr Lys Val Ala Met Thr Ser Lys Val Tyr Asp Pro 
            980                 985                 990         


Glu Gln Arg Lys Arg Met Ile Thr  Gly Pro Gln Trp Trp  Ala Arg Cys 
        995                 1000                 1005             


Lys Gln  Met Asn Val Leu Asp  Ser Phe Ile Asn Tyr  Tyr Asp Ser 
    1010                 1015                 1020             


Glu Lys  His Ala Glu Asn Ala  Val Ile Phe Leu His  Gly Asn Ala 
    1025                 1030                 1035             


Thr Ser  Ser Tyr Leu Trp Arg  His Val Val Pro His  Ile Glu Pro 
    1040                 1045                 1050             


Val Ala  Arg Cys Ile Ile Pro  Asp Leu Ile Gly Met  Gly Lys Ser 
    1055                 1060                 1065             


Gly Lys  Ser Gly Asn Gly Ser  Tyr Arg Leu Leu Asp  His Tyr Lys 
    1070                 1075                 1080             


Tyr Leu  Thr Ala Trp Phe Glu  Leu Leu Asn Leu Pro  Lys Lys Ile 
    1085                 1090                 1095             


Ile Phe  Val Gly His Asp Trp  Gly Ala Ala Leu Ala  Phe His Tyr 
    1100                 1105                 1110             


Ala Tyr  Glu His Gln Asp Arg  Ile Lys Ala Ile Val  His Met Glu 
    1115                 1120                 1125             


Ser Val  Val Asp Val Ile Glu  Ser Trp Asp Glu Trp  Pro Asp Ile 
    1130                 1135                 1140             


Glu Glu  Asp Ile Ala Leu Ile  Lys Ser Glu Glu Gly  Glu Lys Met 
    1145                 1150                 1155             


Val Leu  Glu Asn Asn Phe Phe  Val Glu Thr Val Leu  Pro Ser Lys 
    1160                 1165                 1170             


Ile Met  Arg Lys Leu Glu Pro  Glu Glu Phe Ala Ala  Tyr Leu Glu 
    1175                 1180                 1185             


Pro Phe  Lys Glu Lys Gly Glu  Val Arg Arg Pro Thr  Leu Ser Trp 
    1190                 1195                 1200             


Pro Arg  Glu Ile Pro Leu Val  Lys Gly Gly Lys Pro  Asp Val Val 
    1205                 1210                 1215             


Gln Ile  Val Arg Asn Tyr Asn  Ala Tyr Leu Arg Ala  Ser Asp Asp 
    1220                 1225                 1230             


Leu Pro  Lys Leu Phe Ile Glu  Ser Asp Pro Gly Phe  Phe Ser Asn 
    1235                 1240                 1245             


Ala Ile  Val Glu Gly Ala Lys  Lys Phe Pro Asn Thr  Glu Phe Val 
    1250                 1255                 1260             


Lys Val  Lys Gly Leu His Phe  Leu Gln Glu Asp Ala  Pro Asp Glu 
    1265                 1270                 1275             


Met Gly  Lys Tyr Ile Lys Ser  Phe Val Glu Arg Val  Leu Lys Asn 
    1280                 1285                 1290             


Glu Gln  Thr Thr Leu Tyr Asn  Lys Val Ala Ser Gly  Gly Gly Gly 
    1295                 1300                 1305             


Ser Gly  Ile Glu Tyr Gly Asp  Lys Glu Arg Lys Ala  Asp Ala Lys 
    1310                 1315                 1320             


Met Val  Cys Asp Val Val Ser  Arg Met Glu Asp Thr  Glu Pro Phe 
    1325                 1330                 1335             


Ser Ala  Glu Leu Leu Ser Ala  Met Met Arg Leu Trp  Gly Asp Ser 
    1340                 1345                 1350             


Gly Ile  Gln Glu Cys Phe Asn  Arg Ser Arg Glu Tyr  Gln Leu Asn 
    1355                 1360                 1365             


Asp Ser  Ala Lys Tyr Tyr Leu  Asp Ser Leu Asp Arg  Ile Gly Ala 
    1370                 1375                 1380             


Ala Asp  Tyr Gln Pro Thr Glu  Gln Asp Ile Leu Arg  Thr Arg Val 
    1385                 1390                 1395             


Lys Thr  Thr Gly Ile Val Glu  Thr His Phe Thr Phe  Lys Asn Leu 
    1400                 1405                 1410             


His Phe  Arg Leu Phe Asp Val  Gly Gly Gln Arg Ser  Glu Arg Lys 
    1415                 1420                 1425             


Lys Trp  Ile His Cys Phe Glu  Asp Val Thr Ala Ile  Ile Phe Cys 
    1430                 1435                 1440             


Val Ala  Leu Ser Gly Tyr Asp  Gln Val Leu His Glu  Asp Glu Thr 
    1445                 1450                 1455             


Thr Asn  Arg Met His Glu Ser  Leu Met Leu Phe Asp  Ser Ile Cys 
    1460                 1465                 1470             


Asn Asn  Lys Phe Phe Ile Asp  Thr Ser Ile Ile Leu  Phe Leu Asn 
    1475                 1480                 1485             


Lys Lys  Asp Leu Phe Gly Glu  Lys Ile Lys Lys Ser  Pro Leu Thr 
    1490                 1495                 1500             


Ile Cys  Phe Pro Glu Tyr Thr  Gly Pro Asn Thr Tyr  Glu Asp Ala 
    1505                 1510                 1515             


Ala Ala  Tyr Ile Gln Ala Gln  Phe Glu Ser Lys Asn  Arg Ser Pro 
    1520                 1525                 1530             


Asn Lys  Glu Ile Tyr Cys His  Met Thr Cys Ala Thr  Asp Thr Asn 
    1535                 1540                 1545             


Asn Ile  Gln Val Val Phe Asp  Ala Val Thr Asp Ile  Ile Ile Ala 
    1550                 1555                 1560             


Asn Asn  Leu Arg Gly Cys Gly  Leu Tyr 
    1565                 1570         


<210>  98
<211>  3369
<212>  DNA
<213>  Artificial

<220>
<223>  Ox1R-L-G (RLG) fusion protein encoding DNA

<400>  98
atggagccct cagccacccc aggggcccag atgggggtcc cccctggcag cagagagccg       60

tcccctgtgc ctccagacta tgaagatgag tttctccgct atctgtggcg cgattatctg      120

tacccaaaac agtatgagtg ggtcctcatc gcagcctatg tggctgtgtt cgtcgtggcc      180

ctggtgggca acacgctggt ctgcctggcc gtgtggcgga accaccacat gaggacagtc      240

accaactact tcattgtcaa cctgtccctg gctgacgttc tggtgactgc tatctgcctg      300

ccggccagcc tgctggtgga catcactgag tcctggctgt tcggccatgc cctctgcaag      360

gtcatcccct atctacaggc tgtgtccgtg tcagtggcag tgctaactct cagcttcatc      420

gccctggacc gctggtatgc catctgccac ccactattgt tcaagagcac agcccggcgg      480

gcccgtggct ccatcctggg catctgggct gtgtcgctgg ccatcatggt gccccaggct      540

gcagtcatgg aatgcagcag tgtgctgcct gagctagcca accgcacacg gctcttctca      600

gtctgtgatg aacgctgggc agatgacctc tatcccaaga tctaccacag ttgcttcttt      660

attgtcacct acctggcccc actgggcctc atggccatgg cctatttcca gatattccgc      720

aagctctggg gccgccagat ccccggcacc acctcagcac tggtgcggaa ctggaagcgc      780

ccctcagacc agctggggga cctggagcag ggcctgagtg gagagcccca gccccggggc      840

cgcgccttcc tggctgaagt gaagcagatg cgtgcacgga ggaagacagc caagatgctg      900

atggtggtgc tgctggtctt cgccctctgc tacctgccca tcagcgtcct caatgtcctt      960

aagagggtgt tcgggatgtt ccgccaagcc agtgaccgcg aagctgtcta cgcctgcttc     1020

accttctccc actggctggt gtacgccaac agcgctgcca accccatcat ctacaacttc     1080

ctcagtggca aattccggga gcagtttaag gctgccttct cctgctgcct gcctggcctg     1140

ggtccctgcg gctctctgaa ggcccctagt ccccgctcct ctgccagcca caagtccttg     1200

tccttgcaga gccgatgctc catctccaaa atctctgagc atgtggtgct caccagcgtc     1260

accacagtgc tgccctctgg aggaggcgga tctacaactt tgtatacaaa agttgccatg     1320

accagcaagg tgtacgaccc cgagcagagg aagaggatga tcaccggccc ccagtggtgg     1380

gccaggtgca agcagatgaa cgtgctggac agcttcatca actactacga cagcgagaag     1440

cacgccgaga acgccgtgat cttcctgcac ggcaacgcca ccagcagcta cctgtggagg     1500

cacgtggtgc cccacatcga gcccgtggcc aggtgcatca tccccgatct gatcggcatg     1560

ggcaagagcg gcaagagcgg caacggcagc tacaggctgc tggaccacta caagtacctg     1620

accgcctggt tcgagctcct gaacctgccc aagaagatca tcttcgtggg ccacgactgg     1680

ggagctgcac tggccttcca ctacgcctac gagcaccagg acagaatcaa ggccatcgtg     1740

cacatggaga gcgtggtgga cgtgatcgag agctgggacg agtggccaga catcgaggag     1800

gacatcgccc tgatcaagag cgaggagggc gagaagatgg tgctggagaa caacttcttc     1860

gtggagaccg tcctgcccag caagatcatg agaaagctgg agcccgagga gttcgccgcc     1920

tacctggagc ccttcaagga gaagggcgag gtgagaagac ccaccctgag ctggcccaga     1980

gagatccccc tggtgaaggg cggcaagccc gacgtggtgc agatcgtgag aaactacaac     2040

gcctacctga gagccagcga cgacctgccc aagctgttca tcgagagcga ccccggcttc     2100

ttcagcaacg ccatcgtgga gggcgccaag aagttcccca acaccgagtt cgtgaaggtg     2160

aagggcctgc actttctcca ggaagacgcc cccgacgaga tgggcaagta catcaagagc     2220

ttcgtggaga gagtgctgaa gaacgagaca actttgtata ataaagttgc ctctggaggc     2280

ggaggatcta tgactctgga gtccatcatg gcgtgctgcc tgagcgagga ggccaaggaa     2340

gcccggcgga tcaacgacga gatcgagcgg cagctccgca gggacaagcg ggacgcccgc     2400

cgggagctca agctgctgct gctcgggaca ggagagagtg gcaagagtac gtttatcaag     2460

cagatgagaa tcatccatgg gtcaggatac tctgatgaag ataaaagggg cttcaccaag     2520

ctggtgtatc agaacatctt cacggccatg caggccatga tcagagccat ggacacactc     2580

aagatcccat acaagtatga gcacaataag gctcatgcac aattagttcg agaagttgat     2640

gtggagaagg tgtctgcttt tgagaatcca tatgtagatg caataaagag tttatggaat     2700

gatcctggaa tccaggaatg ctatgataga cgacgagaat atcaattatc tgactctacc     2760

aaatactatc ttaatgactt ggaccgcgta gctgaccctg cctacctgcc tacgcaacaa     2820

gatgtgctta gagttcgagt ccccaccaca gggatcatcg aatacccctt tgacttacaa     2880

agtgtcattt tcagaatggt cgatgtaggg ggccaaaggt cagagagaag aaaatggata     2940

cactgctttg aaaatgtcac ctctatcatg tttctagtag cgcttagtga atatgatcaa     3000

gttctcgtgg agtcagacaa tgagaaccga atggaggaaa gcaaggctct ctttagaaca     3060

attatcacat acccctggtt ccagaactcc tcggttattc tgttcttaaa caagaaagat     3120

cttctagagg agaaaatcat gtattcccat ctagtcgact acttcccaga atatgatgga     3180

ccccagagag atgcccaggc agcccgagaa ttcattctga agatgttcgt ggacctgaac     3240

ccagacagtg acaaaattat ctactcccac ttcacgtgcg ccacagacac cgagaatatc     3300

cgctttgtct ttgctgccgt caaggacacc atcctccagt tgaacctgaa ggagtacaat     3360

ctggtctaa                                                             3369


<210>  99
<211>  1122
<212>  PRT
<213>  Artificial

<220>
<223>  Ox1R-L-G (RLG) fusion protein

<400>  99

Met Glu Pro Ser Ala Thr Pro Gly Ala Gln Met Gly Val Pro Pro Gly 
1               5                   10                  15      


Ser Arg Glu Pro Ser Pro Val Pro Pro Asp Tyr Glu Asp Glu Phe Leu 
            20                  25                  30          


Arg Tyr Leu Trp Arg Asp Tyr Leu Tyr Pro Lys Gln Tyr Glu Trp Val 
        35                  40                  45              


Leu Ile Ala Ala Tyr Val Ala Val Phe Val Val Ala Leu Val Gly Asn 
    50                  55                  60                  


Thr Leu Val Cys Leu Ala Val Trp Arg Asn His His Met Arg Thr Val 
65                  70                  75                  80  


Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala Asp Val Leu Val Thr 
                85                  90                  95      


Ala Ile Cys Leu Pro Ala Ser Leu Leu Val Asp Ile Thr Glu Ser Trp 
            100                 105                 110         


Leu Phe Gly His Ala Leu Cys Lys Val Ile Pro Tyr Leu Gln Ala Val 
        115                 120                 125             


Ser Val Ser Val Ala Val Leu Thr Leu Ser Phe Ile Ala Leu Asp Arg 
    130                 135                 140                 


Trp Tyr Ala Ile Cys His Pro Leu Leu Phe Lys Ser Thr Ala Arg Arg 
145                 150                 155                 160 


Ala Arg Gly Ser Ile Leu Gly Ile Trp Ala Val Ser Leu Ala Ile Met 
                165                 170                 175     


Val Pro Gln Ala Ala Val Met Glu Cys Ser Ser Val Leu Pro Glu Leu 
            180                 185                 190         


Ala Asn Arg Thr Arg Leu Phe Ser Val Cys Asp Glu Arg Trp Ala Asp 
        195                 200                 205             


Asp Leu Tyr Pro Lys Ile Tyr His Ser Cys Phe Phe Ile Val Thr Tyr 
    210                 215                 220                 


Leu Ala Pro Leu Gly Leu Met Ala Met Ala Tyr Phe Gln Ile Phe Arg 
225                 230                 235                 240 


Lys Leu Trp Gly Arg Gln Ile Pro Gly Thr Thr Ser Ala Leu Val Arg 
                245                 250                 255     


Asn Trp Lys Arg Pro Ser Asp Gln Leu Gly Asp Leu Glu Gln Gly Leu 
            260                 265                 270         


Ser Gly Glu Pro Gln Pro Arg Gly Arg Ala Phe Leu Ala Glu Val Lys 
        275                 280                 285             


Gln Met Arg Ala Arg Arg Lys Thr Ala Lys Met Leu Met Val Val Leu 
    290                 295                 300                 


Leu Val Phe Ala Leu Cys Tyr Leu Pro Ile Ser Val Leu Asn Val Leu 
305                 310                 315                 320 


Lys Arg Val Phe Gly Met Phe Arg Gln Ala Ser Asp Arg Glu Ala Val 
                325                 330                 335     


Tyr Ala Cys Phe Thr Phe Ser His Trp Leu Val Tyr Ala Asn Ser Ala 
            340                 345                 350         


Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser Gly Lys Phe Arg Glu Gln 
        355                 360                 365             


Phe Lys Ala Ala Phe Ser Cys Cys Leu Pro Gly Leu Gly Pro Cys Gly 
    370                 375                 380                 


Ser Leu Lys Ala Pro Ser Pro Arg Ser Ser Ala Ser His Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Gln Ser Arg Cys Ser Ile Ser Lys Ile Ser Glu His Val Val 
                405                 410                 415     


Leu Thr Ser Val Thr Thr Val Leu Pro Ser Gly Gly Gly Gly Ser Thr 
            420                 425                 430         


Thr Leu Tyr Thr Lys Val Ala Met Thr Ser Lys Val Tyr Asp Pro Glu 
        435                 440                 445             


Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys 
    450                 455                 460                 


Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys 
465                 470                 475                 480 


His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala Thr Ser Ser 
                485                 490                 495     


Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro Val Ala Arg Cys 
            500                 505                 510         


Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn 
        515                 520                 525             


Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe 
    530                 535                 540                 


Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp 
545                 550                 555                 560 


Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu His Gln Asp Arg Ile 
                565                 570                 575     


Lys Ala Ile Val His Met Glu Ser Val Val Asp Val Ile Glu Ser Trp 
            580                 585                 590         


Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu 
        595                 600                 605             


Glu Gly Glu Lys Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val 
    610                 615                 620                 


Leu Pro Ser Lys Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala 
625                 630                 635                 640 


Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu 
                645                 650                 655     


Ser Trp Pro Arg Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val 
            660                 665                 670         


Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp 
        675                 680                 685             


Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala 
    690                 695                 700                 


Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val 
705                 710                 715                 720 


Lys Gly Leu His Phe Leu Gln Glu Asp Ala Pro Asp Glu Met Gly Lys 
                725                 730                 735     


Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn Glu Thr Thr Leu 
            740                 745                 750         


Tyr Asn Lys Val Ala Ser Gly Gly Gly Gly Ser Met Thr Leu Glu Ser 
        755                 760                 765             


Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala Arg Arg Ile 
    770                 775                 780                 


Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg Asp Ala Arg 
785                 790                 795                 800 


Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys Ser 
                805                 810                 815     


Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser Asp 
            820                 825                 830         


Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe Thr 
        835                 840                 845             


Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Lys Ile Pro Tyr 
    850                 855                 860                 


Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg Glu Val Asp 
865                 870                 875                 880 


Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp Ala Ile Lys 
                885                 890                 895     


Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg 
            900                 905                 910         


Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu Asp 
        915                 920                 925             


Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu Arg 
    930                 935                 940                 


Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu Gln 
945                 950                 955                 960 


Ser Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg 
                965                 970                 975     


Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe Leu 
            980                 985                 990         


Val Ala Leu Ser Glu Tyr Asp Gln  Val Leu Val Glu Ser  Asp Asn Glu 
        995                 1000                 1005             


Asn Arg  Met Glu Glu Ser Lys  Ala Leu Phe Arg Thr  Ile Ile Thr 
    1010                 1015                 1020             


Tyr Pro  Trp Phe Gln Asn Ser  Ser Val Ile Leu Phe  Leu Asn Lys 
    1025                 1030                 1035             


Lys Asp  Leu Leu Glu Glu Lys  Ile Met Tyr Ser His  Leu Val Asp 
    1040                 1045                 1050             


Tyr Phe  Pro Glu Tyr Asp Gly  Pro Gln Arg Asp Ala  Gln Ala Ala 
    1055                 1060                 1065             


Arg Glu  Phe Ile Leu Lys Met  Phe Val Asp Leu Asn  Pro Asp Ser 
    1070                 1075                 1080             


Asp Lys  Ile Ile Tyr Ser His  Phe Thr Cys Ala Thr  Asp Thr Glu 
    1085                 1090                 1095             


Asn Ile  Arg Phe Val Phe Ala  Ala Val Lys Asp Thr  Ile Leu Gln 
    1100                 1105                 1110             


Leu Asn  Leu Lys Glu Tyr Asn  Leu Val 
    1115                 1120         


<210>  100
<211>  3426
<212>  DNA
<213>  Artificial

<220>
<223>  Ox2R-L-G (RLG) fusion protein encoding DNA

<400>  100
atgtccggca ccaaattgga ggactccccc ccttgtcgca actggtcatc tgcttcggag       60

ctgaatgaaa ctcaagagcc ctttttaaac cccaccgact atgacgacga ggaattcctg      120

cggtacctgt ggagggaata cctgcacccg aaagaatatg agtgggtcct gatcgccggg      180

tacatcatcg tgttcgtcgt ggctctcatt gggaacgtcc tggtttgtgt ggcagtgtgg      240

aagaaccacc acatgaggac ggtaaccaac tacttcatag tcaatctttc tctggctgat      300

gtgctcgtga ccatcacctg ccttccagcc acactggtcg tggatatcac tgagacctgg      360

ttttttggac agtccctttg caaagtgatt ccttatctac agaccgtgtc ggtgtctgtg      420

tctgtcctca cactgagctg tatcgccttg gatcggtggt atgcaatctg tcaccctttg      480

atgtttaaga gcacagcaaa gcgggcccgt aacagcattg tcatcatctg gattgtctcc      540

tgcattataa tgattcctca ggccatcgtc atggagtgca gcaccgtgtt cccaggctta      600

gccaataaaa ccaccctctt tacggtgtgt gatgagcgct ggggtggtga aatttatccc      660

aagatgtacc acatctgttt ctttctggtg acatacatgg caccactgtg tctcatggtg      720

ttggcttatc tgcaaatatt tcgcaaactc tggtgtcgac agatccctgg aacatcatct      780

gtagttcaga gaaaatggaa gcccctgcag cctgtttcac agcctcgagg gccaggacag      840

ccaacgaagt cccggatgag cgctgtggcg gctgaaataa agcagatccg agccagaagg      900

aaaacagccc ggatgttgat ggttgtgctt ttggtatttg caatttgcta tctaccaatt      960

agcatcctca atgtgctaaa gagagtattt gggatgtttg cccatactga agacagagag     1020

actgtgtatg cctggtttac cttttcacac tggcttgtat atgccaatag tgctgcgaat     1080

ccaattattt ataattttct cagtggaaaa tttcgagagg aatttaaagc tgcgttttct     1140

tgctgttgcc ttggagttca ccatcgccag gaggatcggc tcaccagggg acgaactagc     1200

acagagagcc ggaagtcctt gaccactcaa atcagcaact ttgataacat atcaaaactt     1260

tctgaacaag ttgtgctcac tagcataagc acactcccag cagccaatgg agcaggacca     1320

cttcaaaact ggtctggagg aggcggatct acaactttgt atacaaaagt tgccatgacc     1380

agcaaggtgt acgaccccga gcagaggaag aggatgatca ccggccccca gtggtgggcc     1440

aggtgcaagc agatgaacgt gctggacagc ttcatcaact actacgacag cgagaagcac     1500

gccgagaacg ccgtgatctt cctgcacggc aacgccacca gcagctacct gtggaggcac     1560

gtggtgcccc acatcgagcc cgtggccagg tgcatcatcc ccgatctgat cggcatgggc     1620

aagagcggca agagcggcaa cggcagctac aggctgctgg accactacaa gtacctgacc     1680

gcctggttcg agctcctgaa cctgcccaag aagatcatct tcgtgggcca cgactgggga     1740

gctgcactgg ccttccacta cgcctacgag caccaggaca gaatcaaggc catcgtgcac     1800

atggagagcg tggtggacgt gatcgagagc tgggacgagt ggccagacat cgaggaggac     1860

atcgccctga tcaagagcga ggagggcgag aagatggtgc tggagaacaa cttcttcgtg     1920

gagaccgtcc tgcccagcaa gatcatgaga aagctggagc ccgaggagtt cgccgcctac     1980

ctggagccct tcaaggagaa gggcgaggtg agaagaccca ccctgagctg gcccagagag     2040

atccccctgg tgaagggcgg caagcccgac gtggtgcaga tcgtgagaaa ctacaacgcc     2100

tacctgagag ccagcgacga cctgcccaag ctgttcatcg agagcgaccc cggcttcttc     2160

agcaacgcca tcgtggaggg cgccaagaag ttccccaaca ccgagttcgt gaaggtgaag     2220

ggcctgcact ttctccagga agacgccccc gacgagatgg gcaagtacat caagagcttc     2280

gtggagagag tgctgaagaa cgagacaact ttgtataata aagttgcctc tggaggcgga     2340

ggatctatga ctctggagtc catcatggcg tgctgcctga gcgaggaggc caaggaagcc     2400

cggcggatca acgacgagat cgagcggcag ctccgcaggg acaagcggga cgcccgccgg     2460

gagctcaagc tgctgctgct cgggacagga gagagtggca agagtacgtt tatcaagcag     2520

atgagaatca tccatgggtc aggatactct gatgaagata aaaggggctt caccaagctg     2580

gtgtatcaga acatcttcac ggccatgcag gccatgatca gagccatgga cacactcaag     2640

atcccataca agtatgagca caataaggct catgcacaat tagttcgaga agttgatgtg     2700

gagaaggtgt ctgcttttga gaatccatat gtagatgcaa taaagagttt atggaatgat     2760

cctggaatcc aggaatgcta tgatagacga cgagaatatc aattatctga ctctaccaaa     2820

tactatctta atgacttgga ccgcgtagct gaccctgcct acctgcctac gcaacaagat     2880

gtgcttagag ttcgagtccc caccacaggg atcatcgaat acccctttga cttacaaagt     2940

gtcattttca gaatggtcga tgtagggggc caaaggtcag agagaagaaa atggatacac     3000

tgctttgaaa atgtcacctc tatcatgttt ctagtagcgc ttagtgaata tgatcaagtt     3060

ctcgtggagt cagacaatga gaaccgaatg gaggaaagca aggctctctt tagaacaatt     3120

atcacatacc cctggttcca gaactcctcg gttattctgt tcttaaacaa gaaagatctt     3180

ctagaggaga aaatcatgta ttcccatcta gtcgactact tcccagaata tgatggaccc     3240

cagagagatg cccaggcagc ccgagaattc attctgaaga tgttcgtgga cctgaaccca     3300

gacagtgaca aaattatcta ctcccacttc acgtgcgcca cagacaccga gaatatccgc     3360

tttgtctttg ctgccgtcaa ggacaccatc ctccagttga acctgaagga gtacaatctg     3420

gtctaa                                                                3426


<210>  101
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Ox2R-L-G (RLG) fusion protein

<400>  101

Met Ser Gly Thr Lys Leu Glu Asp Ser Pro Pro Cys Arg Asn Trp Ser 
1               5                   10                  15      


Ser Ala Ser Glu Leu Asn Glu Thr Gln Glu Pro Phe Leu Asn Pro Thr 
            20                  25                  30          


Asp Tyr Asp Asp Glu Glu Phe Leu Arg Tyr Leu Trp Arg Glu Tyr Leu 
        35                  40                  45              


His Pro Lys Glu Tyr Glu Trp Val Leu Ile Ala Gly Tyr Ile Ile Val 
    50                  55                  60                  


Phe Val Val Ala Leu Ile Gly Asn Val Leu Val Cys Val Ala Val Trp 
65                  70                  75                  80  


Lys Asn His His Met Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu 
                85                  90                  95      


Ser Leu Ala Asp Val Leu Val Thr Ile Thr Cys Leu Pro Ala Thr Leu 
            100                 105                 110         


Val Val Asp Ile Thr Glu Thr Trp Phe Phe Gly Gln Ser Leu Cys Lys 
        115                 120                 125             


Val Ile Pro Tyr Leu Gln Thr Val Ser Val Ser Val Ser Val Leu Thr 
    130                 135                 140                 


Leu Ser Cys Ile Ala Leu Asp Arg Trp Tyr Ala Ile Cys His Pro Leu 
145                 150                 155                 160 


Met Phe Lys Ser Thr Ala Lys Arg Ala Arg Asn Ser Ile Val Ile Ile 
                165                 170                 175     


Trp Ile Val Ser Cys Ile Ile Met Ile Pro Gln Ala Ile Val Met Glu 
            180                 185                 190         


Cys Ser Thr Val Phe Pro Gly Leu Ala Asn Lys Thr Thr Leu Phe Thr 
        195                 200                 205             


Val Cys Asp Glu Arg Trp Gly Gly Glu Ile Tyr Pro Lys Met Tyr His 
    210                 215                 220                 


Ile Cys Phe Phe Leu Val Thr Tyr Met Ala Pro Leu Cys Leu Met Val 
225                 230                 235                 240 


Leu Ala Tyr Leu Gln Ile Phe Arg Lys Leu Trp Cys Arg Gln Ile Pro 
                245                 250                 255     


Gly Thr Ser Ser Val Val Gln Arg Lys Trp Lys Pro Leu Gln Pro Val 
            260                 265                 270         


Ser Gln Pro Arg Gly Pro Gly Gln Pro Thr Lys Ser Arg Met Ser Ala 
        275                 280                 285             


Val Ala Ala Glu Ile Lys Gln Ile Arg Ala Arg Arg Lys Thr Ala Arg 
    290                 295                 300                 


Met Leu Met Val Val Leu Leu Val Phe Ala Ile Cys Tyr Leu Pro Ile 
305                 310                 315                 320 


Ser Ile Leu Asn Val Leu Lys Arg Val Phe Gly Met Phe Ala His Thr 
                325                 330                 335     


Glu Asp Arg Glu Thr Val Tyr Ala Trp Phe Thr Phe Ser His Trp Leu 
            340                 345                 350         


Val Tyr Ala Asn Ser Ala Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser 
        355                 360                 365             


Gly Lys Phe Arg Glu Glu Phe Lys Ala Ala Phe Ser Cys Cys Cys Leu 
    370                 375                 380                 


Gly Val His His Arg Gln Glu Asp Arg Leu Thr Arg Gly Arg Thr Ser 
385                 390                 395                 400 


Thr Glu Ser Arg Lys Ser Leu Thr Thr Gln Ile Ser Asn Phe Asp Asn 
                405                 410                 415     


Ile Ser Lys Leu Ser Glu Gln Val Val Leu Thr Ser Ile Ser Thr Leu 
            420                 425                 430         


Pro Ala Ala Asn Gly Ala Gly Pro Leu Gln Asn Trp Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Thr Thr Leu Tyr Thr Lys Val Ala Met Thr Ser Lys Val Tyr 
    450                 455                 460                 


Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro Gln Trp Trp Ala 
465                 470                 475                 480 


Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile Asn Tyr Tyr Asp 
                485                 490                 495     


Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu His Gly Asn Ala 
            500                 505                 510         


Thr Ser Ser Tyr Leu Trp Arg His Val Val Pro His Ile Glu Pro Val 
        515                 520                 525             


Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly Lys Ser Gly Lys 
    530                 535                 540                 


Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr Lys Tyr Leu Thr 
545                 550                 555                 560 


Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile Ile Phe Val Gly 
                565                 570                 575     


His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ala Tyr Glu His Gln 
            580                 585                 590         


Asp Arg Ile Lys Ala Ile Val His Met Glu Ser Val Val Asp Val Ile 
        595                 600                 605             


Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp Ile Ala Leu Ile 
    610                 615                 620                 


Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn Asn Phe Phe Val 
625                 630                 635                 640 


Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu Glu Pro Glu Glu 
                645                 650                 655     


Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly Glu Val Arg Arg 
            660                 665                 670         


Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val Lys Gly Gly Lys 
        675                 680                 685             


Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg Ala 
    690                 695                 700                 


Ser Asp Asp Leu Pro Lys Leu Phe Ile Glu Ser Asp Pro Gly Phe Phe 
705                 710                 715                 720 


Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu Phe 
                725                 730                 735     


Val Lys Val Lys Gly Leu His Phe Leu Gln Glu Asp Ala Pro Asp Glu 
            740                 745                 750         


Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn Glu 
        755                 760                 765             


Thr Thr Leu Tyr Asn Lys Val Ala Ser Gly Gly Gly Gly Ser Met Thr 
    770                 775                 780                 


Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala 
785                 790                 795                 800 


Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg 
                805                 810                 815     


Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser 
            820                 825                 830         


Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly 
        835                 840                 845             


Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn 
    850                 855                 860                 


Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Lys 
865                 870                 875                 880 


Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg 
                885                 890                 895     


Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp 
            900                 905                 910         


Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp 
        915                 920                 925             


Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn 
    930                 935                 940                 


Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp 
945                 950                 955                 960 


Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe 
                965                 970                 975     


Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg 
            980                 985                 990         


Ser Glu Arg Arg Lys Trp Ile His  Cys Phe Glu Asn Val  Thr Ser Ile 
        995                 1000                 1005             


Met Phe  Leu Val Ala Leu Ser  Glu Tyr Asp Gln Val  Leu Val Glu 
    1010                 1015                 1020             


Ser Asp  Asn Glu Asn Arg Met  Glu Glu Ser Lys Ala  Leu Phe Arg 
    1025                 1030                 1035             


Thr Ile  Ile Thr Tyr Pro Trp  Phe Gln Asn Ser Ser  Val Ile Leu 
    1040                 1045                 1050             


Phe Leu  Asn Lys Lys Asp Leu  Leu Glu Glu Lys Ile  Met Tyr Ser 
    1055                 1060                 1065             


His Leu  Val Asp Tyr Phe Pro  Glu Tyr Asp Gly Pro  Gln Arg Asp 
    1070                 1075                 1080             


Ala Gln  Ala Ala Arg Glu Phe  Ile Leu Lys Met Phe  Val Asp Leu 
    1085                 1090                 1095             


Asn Pro  Asp Ser Asp Lys Ile  Ile Tyr Ser His Phe  Thr Cys Ala 
    1100                 1105                 1110             


Thr Asp  Thr Glu Asn Ile Arg  Phe Val Phe Ala Ala  Val Lys Asp 
    1115                 1120                 1125             


Thr Ile  Leu Gln Leu Asn Leu  Lys Glu Tyr Asn Leu  Val 
    1130                 1135                 1140     


<210>  102
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Pro Val Ile Asn Ile Glu Asp Leu Thr Glu Lys Asp Lys Leu Lys 
1               5                   10                  15      


Met Glu Val Asp Gln Leu Lys Lys Glu Val Thr Leu Glu Arg Met Leu 
            20                  25                  30          


Val Ser Lys Cys Cys Glu Glu Val Arg Asp Tyr Val Glu Glu Arg Ser 
        35                  40                  45              


Gly Glu Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe 
    50                  55                  60                  


Lys Glu Leu Lys Gly Gly Cys Val Ile Ser 
65                  70                  


<210>  103
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Ser Asn Asn Thr Ala Ser Ile Ala Gln Ala Arg Lys Leu Val 
1               5                   10                  15      


Glu Gln Leu Lys Met Glu Ala Asn Ile Asp Arg Ile Lys Val Ser Lys 
            20                  25                  30          


Ala Ala Ala Asp Leu Met Ala Tyr Cys Glu Ala His Ala Lys Glu Asp 
        35                  40                  45              


Pro Leu Leu Thr Pro Val Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys 
    50                  55                  60                  


Lys Phe Phe Cys Ala Ile Leu 
65                  70      


<210>  104
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Lys Gly Glu Thr Pro Val Asn Ser Thr Met Ser Ile Gly Gln Ala 
1               5                   10                  15      


Arg Lys Met Val Glu Gln Leu Lys Ile Glu Ala Ser Leu Cys Arg Ile 
            20                  25                  30          


Lys Val Ser Lys Ala Ala Ala Asp Leu Met Thr Tyr Cys Asp Ala His 
        35                  40                  45              


Ala Cys Glu Asp Pro Leu Ile Thr Pro Val Pro Thr Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Ala Leu Leu 
65                  70                  75  


<210>  105
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  106
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ser Gly Ser Ser Ser Val Ala Ala Met Lys Lys Val Val Gln Gln 
1               5                   10                  15      


Leu Arg Leu Glu Ala Gly Leu Asn Arg Val Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Asp Leu Lys Gln Phe Cys Leu Gln Asn Ala Gln His Asp Pro Leu 
        35                  40                  45              


Leu Thr Gly Val Ser Ser Ser Thr Asn Pro Phe Arg Pro Gln Lys Val 
    50                  55                  60                  


Cys Ser Phe Leu 
65              


<210>  107
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ser Ala Thr Asn Asn Ile Ala Gln Ala Arg Lys Leu Val Glu Gln 
1               5                   10                  15      


Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala Ala 
            20                  25                  30          


Ser Asp Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro Leu 
        35                  40                  45              


Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys Pro 
    50                  55                  60                  


Cys Ile Ile Leu 
65              


<210>  108
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ser Asn Asn Met Ala Lys Ile Ala Glu Ala Arg Lys Thr Val Glu 
1               5                   10                  15      


Gln Leu Lys Leu Glu Val Asn Ile Asp Arg Met Lys Val Ser Gln Ala 
            20                  25                  30          


Ala Ala Glu Leu Leu Ala Phe Cys Glu Thr His Ala Lys Asp Asp Pro 
        35                  40                  45              


Leu Val Thr Pro Val Pro Ala Ala Glu Asn Pro Phe Arg Asp Lys Arg 
    50                  55                  60                  


Leu Phe Cys Val Leu Leu 
65                  70  


<210>  109
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ser Ser Gly Ala Ser Ala Ser Ala Leu Gln Arg Leu Val Glu Gln 
1               5                   10                  15      


Leu Lys Leu Glu Ala Gly Val Glu Arg Ile Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala Cys Lys Asp Ala Leu 
        35                  40                  45              


Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe Arg Glu Pro Arg Ser 
    50                  55                  60                  


Cys Ala Leu Leu 
65              


<210>  110
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Pro Ala Leu His Ile Glu Asp Leu Pro Glu Lys Glu Lys Leu Lys 
1               5                   10                  15      


Met Glu Val Glu Gln Leu Arg Lys Glu Val Lys Leu Gln Arg Gln Gln 
            20                  25                  30          


Val Ser Lys Cys Ser Glu Glu Ile Lys Asn Tyr Ile Glu Glu Arg Ser 
        35                  40                  45              


Gly Glu Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe 
    50                  55                  60                  


Lys Glu Lys Gly Ser Cys Val Ile Ser 
65                  70              


<210>  111
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ser Ser Lys Thr Ala Ser Thr Asn Asn Ile Ala Gln Ala Arg Arg 
1               5                   10                  15      


Thr Val Gln Gln Leu Arg Leu Glu Ala Ser Ile Glu Arg Ile Lys Val 
            20                  25                  30          


Ser Lys Ala Ser Ala Asp Leu Met Ser Tyr Cys Glu Glu His Ala Arg 
        35                  40                  45              


Ser Asp Pro Leu Leu Ile Gly Ile Pro Thr Ser Glu Asn Pro Phe Lys 
    50                  55                  60                  


Asp Lys Lys Thr Cys Ile Ile Leu 
65                  70          


<210>  112
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Glu Glu Trp Asp Val Pro Gln Met Lys Lys Glu Val Glu Ser Leu 
1               5                   10                  15      


Lys Tyr Gln Leu Ala Phe Gln Arg Glu Met Ala Ser Lys Thr Ile Pro 
            20                  25                  30          


Glu Leu Leu Lys Trp Ile Glu Asp Gly Ile Pro Lys Asp Pro Phe Leu 
        35                  40                  45              


Asn Pro Asp Leu Met Lys Asn Asn Pro Trp Val Glu Lys Gly Lys Cys 
    50                  55                  60                  


Thr Ile Leu 
65          


