                         SEQUENCE LISTING

<110>  Scil Proteins GmbH
 
<120>  Verfahren zur Herstellung von rekombinantem Thrombin

<130>  P29042-WO

<150>  EP10160740.6
<151>  2010-04-22

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe 
1               5                   10                  15      


Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys 
            20                  25                  30          


Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp 
        35                  40                  45              


Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp 
    50                  55                  60                  


Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala 
65                  70                  75                  80  


Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu 
                85                  90                  95      


Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg 
            100                 105                 110         


Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile 
        115                 120                 125             


Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu 
    130                 135                 140                 


Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala 
145                 150                 155                 160 


Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala 
                165                 170                 175     


Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly 
            180                 185                 190         


Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser 
        195                 200                 205             


Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys 
    210                 215                 220                 


Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr 
225                 230                 235                 240 


Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly 
                245                 250                 255     


Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met 
            260                 265                 270         


Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr Gly 
        275                 280                 285             


Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile 
    290                 295                 300                 


Asp Gln Phe Gly Glu 
305                 


<210>  2
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


