                         SEQUENCE LISTING

<110>  nLife Therapeutics S.L.
 
<120>  COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF 
       OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES

<130>  P5518PC00

<150>  EP10382087
<151>  2010-04-19

<150>  EP11382031
<151>  2011-02-09

<150>  US61/325515
<151>  2010-04-19

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  70
<212>  RNA
<213>  Mus musculus

<400>  1
ggugguagug gugguaauag ugguggugau ggagaaggaa gaaguggagg aagaguguag       60

ggcuuacagg                                                              70


<210>  2
<211>  110
<212>  RNA
<213>  Mus musculus

<400>  2
caacaccaca acgucccugg agcccuucgg gacaggcggc aacgauacug gccucuccaa       60

cgugaccuuc agcuaccaag ugaucaccuc ucuuuugcug gggacgcuca                 110


<210>  3
<211>  110
<212>  RNA
<213>  Mus musculus

<400>  3
gcccauggcu gcucuguacc aggugcucaa caaguggacu cugggucagg ucaccuguga       60

ccuguuuauc gcccuggaug ugcugugcug cacuucgucc auccugcacc                 110


<210>  4
<211>  2321
<212>  RNA
<213>  Mus musculus

<400>  4
ugauaguugc aauaaccucc ucucuauucg aaaucccaau ucuucacgau ggaaguuuaa       60

accucggcga uucaaggaag aaaacccaaa cagaaaauau aaacuguaug gacaucuacc      120

augcccacua ggacugccac ccucugcccu auaucuggaa cuuugagguu caagacugcu      180

cugucucucc cucccucuug cucuagaaac aucuguuccc uuuggguguc aauguacacu      240

gcugauucug gucuccaugc acucacggcu ggucugggaa aguuggaacu acuuuggguu      300

auggugcccu ggaauuguuu gccuugcuga auagcaaaag aucccuuucc ccaaugcaca      360

gcacccacuu ucuguauuuu guuuguuugu uuguuuuaac ucaaaaucaa gugacaaaga      420

ugucugcugg aguggacuua uaagcaagaa gccaggccca aaaggaagag ccaagaaggc      480

cugcggaugu uuuccugucc uggugucagc acucaccaaa gaaauugaca aucagacuau      540

uuggaaggaa gaguuuuauu ccuguaguuu guuggcuuuu cuguaaguuc uggaaaggcc      600

uuguggacug cagaaggcgc ccacugcugg ccagggaggg cucauugagg gugcugagau      660

gcccgggaug gcucaccuca cccucaguuu cuuuucuagg agugagcuau gccagagcag      720

cucaccuuga guuugcagcc uccggguucc uccacucacc ucucacagua uccaggagcu      780

aguagagaag uuugaguuug ugcaagaggu uggagacuua gaauuucuaa ggaagugugg      840

gugugaggca cguagaggag guaaggagca aaagggcucc uaagugcuuc caacuccugc      900

ggcgugccca gggggugggg gugaccuaaa ggggcaauuu uaagcauagg augcaaaguu      960

ucucaaucua ccccuucccc cuuucaagga acagcauugu guagcauuuc cuaaaaaugc     1020

ccggauuuau ucuccgggac auucugugcu cacacaaauu ucgcagaucu cugggcucuc     1080

auugugaagg guaucaacac cucaccauua ccuaccuagg aucuugaucu cagagaccua     1140

aaagagagag cgaucucugu ggagucccag ccaagucagc ccccaaauuc ugaggguaaa     1200

accaguuuug uguccucuca auuuuuaaag cauuuuucuc cgcuaggggu ucuuuuccug     1260

cuguuauuuu ugcuguccca cccccaccuc agagaagaaa auuauuuagg ugcuuccuuu     1320

gaauguacau uucuagcuaa gugagagggc aucaaauggu uuugcguuau aucugaacuu     1380

cgaauuuucu guugaauaau gguuuccuuu ucaagcaauu auacggagau uuuuuucacc     1440

ccccaucccc uucagcugua ucuuuccaau gucugcaccu gcuguuuuga aaacccgugc     1500

ugcauuuuuu uuuaaauugc caaaguugcu ggugagaucu cccccuugug uuuauaaaca     1560

gggagaaagg acugcccugc cacaugaagc cauuguuuuu auuuguuaaa cugagcaaag     1620

uuucuuuugc ucuacucuaa agugggaaug aguauuacag ucccuugcaa cagagccauu     1680

ucagaaugua agccuguagg guguccacac cugagagacu gacagggggu ucuguggaga     1740

agacgcacug ggcugggcuu cuccaguaca aacaguacuu guuuguaaau uuagcuugcu     1800

uuauuuguuu guuuguuuau uuauuuauca caaaaaugaa guagaacuau auggccaaau     1860

aauauuuuuc uguaugcuuu acuauuuuua gaccagauca uuuacuugaa auaaagauca     1920

uuuacuugaa auaaaucaau cccuaaauuu cagauguuaa auuggaaacc aagaccucua     1980

acuuccaguu cucuguauuu uuuuuuuucc aauuaggaau guuugaccgu gaugggggag     2040

gggcauugcu cuuguuacuu ugagaaagag acuuuaaaca agacuggaaa gggggcaccc     2100

agcuggaaua uaauugccaa guaauagagc aaucagagaa cuaagugcaa caugccgcac     2160

agcucuaaag aaccccugau gcuuguuuua uuuuaaaaua cuuguauuac aguaaaaugu     2220

uaaugcauca aaauuggccu ucacuuuucc uugugauaau aaaggacuuu aguaauggca     2280

augcuguaau aaacuaagac caguaaccua uauguaccuu u                         2321


<210>  5
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Sense strand of mouse 5-HT1A-specific siRNA

<400>  5
ggaagagugu agggcuuac                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Antisense strand of mouse 5-HT1A-specific siRNA

<400>  6
guaagcccua cacucuucc                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Sense strand of a mouse 5-HT1A-specific siRNA

<400>  7
cgauacuggc cucuccaac                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Antisense strand of a mouse 5-HT1A-specific siRNA

<400>  8
guuggagagg ccaguaucg                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Sense strand of a mouse 5-HT1A-specific siRNA

<400>  9
ggugcucaac aaguggacu                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Antisense strand of a mouse 5-HT1A-specific siRNA

<400>  10
aguccacuug uugagcacc                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Sense strand of a mouse 5-HT1A-specific siRNA

<400>  11
cgauggaagu uuaaaccuc                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Antisense strand of a mouse 5-HT1A-specific siRNA

<400>  12
gagguuuaaa cuuccaucg                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sense strand of a SERT-specific siRNA

<400>  13
cuccuggaac acuggcaact t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sense strand synucleic-specific siRNA

<400>  14
gcuagcuaca acaaguucat t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Antisense strand SERT-specific siRNA

<400>  15
ugaacuuguu guagcuagct t                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  alpha-synuclein siRNA

<400>  16
ggaaagacaa aagaggugtt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  alpha-synuclein siRNA

<400>  17
ggaaagacaa aagaggugtt                                                   20


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  alpha-synuclein siRNA

<400>  18
ggaggaauuu uagaagaggt t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  alpha-synucleic siRNA

<400>  19
uguuggagga gcaguggugt t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  GGACCAGUUGGGCAAGAAUTT

<400>  20
ggaccaguug ggcaagaaut t                                                 21


<210>  21
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  alpha-synuclein hairpins antisense

<400>  21
gatccccgga ccagttgggc aagaatttca agagaattct tgccaactgg tcctttttgg       60

aaa                                                                     63


<210>  22
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  alpha-synuclein hairpin antisense

<400>  22
ctagtttcca aaaaggacca gttgggcaag aattctcttg aaattcttgc ccaactggtc       60

cggg                                                                    64


<210>  23
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synuclein siRNA

<400>  23
gguguggcaa caguggcuga g                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  24
aacaguggcu gagaagacca a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  25
auugcagcag ccacuggcuu u                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  26
aagugacaaa uguuggagga g                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  27
gaagaaggag ccccacagga a                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  28
cgggugugac agcaguagct t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  29
uccugacaau gaggcuuaut t                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein SiRNA

<400>  30
uccugacaau gaggcuuaut t                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  31
cuacgaaccu gaagccuaat t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  32
cuacgaaccu gaagccuaat t                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  33
cuacgaaccu gaagccuaat t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  34
cuauuguaga guggucuaut t                                                 21


<210>  35
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  35
cuaugagccu gaagcuaatt                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synuclein siRNA

<400>  36
cuaugagccu gaagccuaat t                                                 21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  dopamine beta-hydroxylase siRNA

<400>  37
gaccacguac uggugcuaca uta                                               23


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  BAX siRNA

<400>  38
ucgauccugg augaaaccct g                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA

<400>  39
aatcacaccc aacgtgcaga a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA

<400>  40
aactggcagt tctggagcaa a                                                 21


<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (sense)

<400>  41
tcgaagtgat ggaagatcac gc                                                22


<210>  42
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (antisense)

<400>  42
cttcactacc ttctagtgcg ac                                                22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (sense)

<400>  43
cagccgggag tcggcaaggt gc                                                22


<210>  44
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (antisense)

<400>  44
cggccctcag cccttccacg tc                                                22


<210>  45
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (sense)

<400>  45
acgtcctcgg cggcggcagt gtgc                                              24


<210>  46
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  tau SiRNA (antisense)

<400>  46
caggcgcctg cggcgtcaca cgtt                                              24


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (sense)

<400>  47
acgtctccat ggcatctcag c                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA antisense

<400>  48
ttgctgagat gccatggaga c                                                 21


<210>  49
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (sense)

<400>  49
gtggccagat ggaagtaaaa tc                                                22


<210>  50
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (antisense)

<400>  50
ccggtctacc ttcattttag ac                                                22


<210>  51
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (sense)

<400>  51
gtggccagat gcaagtaaaa tc                                                22


<210>  52
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA (antisense)

<400>  52
ccggtctacg ttcattttag ac                                                22


<210>  53
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA

<400>  53
ggttcagcca tgctgcttca aagcc                                             25


<210>  54
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  tau siRNA

<400>  54
tgataatcga caggaggcga ggaca                                             25


<210>  55
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Huntingtin siRNA

<400>  55
aagaggagga ggccgacgcc c                                                 21


<210>  56
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  nonsense siRNA

<400>  56
aguacugcuu acgauacgg                                                    19


<210>  57
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  nonsense siRNA

<400>  57
ccguaucgua agcaguacu                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  nNOS-specific siRNA

<400>  58
caaagagatc gacaccatc                                                    19


<210>  59
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  nNOS specific siRNA

<400>  59
gatggtgtcg atctctttgt t                                                 21


<210>  60
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  nNOS-specific siRNA

<400>  60
cacgcatgtc tggaaaggc                                                    19


<210>  61
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  nNOS-specific siRNA

<400>  61
gcctttccag acatgcgtgt t                                                 21


<210>  62
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  nNOS - specific siRNA

<400>  62
ggtctatcca atgtccaca                                                    19


<210>  63
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  nNOS-specific siRNA

<400>  63
tgtggacatt ggatagacct t                                                 21


<210>  64
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  iNOS-specific siRNA

<400>  64
ccaccagtat gcaatgaat                                                    19


<210>  65
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  iNOS-specific siRNA

<400>  65
acaacaggaa ccuaccagct t                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  iNOS-specific siRNA

<400>  66
gcugguaggu uccuguugut t                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  iNOS-specific antisense

<400>  67
acagctcagt cccttcacca a                                                 21


<210>  68
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  iNOS-specific antisense

<400>  68
tttgccttat actgttcc                                                     18


<210>  69
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  nonsense siRNA

<400>  69
aguacugcuu acgauacgg                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  nonsense siRNA

<400>  70
ccguaucgua agcaguacu                                                    19


