                         SEQUENCE LISTING

<110>  Glaxo Group Limited
 
<120>  BINDING DOMAINS

<130>  MXG/DB64169 WO

<140>  61/326258
<141>  2010-04-21

<160>  113   

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  PEP1-5-19 (anti-TNFalpha dAb

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Ser Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Val Trp Arg Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  2
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM15-10 (anti-human VEGF dAb)

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Pro Glu 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe Gln Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg 
            100                 105             


<210>  3
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM13-25-3 (anti-CEA dAb)

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Pro Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Phe 
        35                  40                  45              


Tyr Gln Val Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ile Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Leu Ala Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  4
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM9-155-25 (anti-IL-4 anti Fcn dAb)

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asp Trp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ala Trp Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Gly Trp Gly Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM7h-14 (anti-HSA dAb)

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  6
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 Nucleotide-sequence

<400>  6
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatcgg aattcccctt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg ctacgtacta ctgtcaacag acgtataggg tgcctcctac gttcggccaa      300

gggaccaagg tggaaatcaa acgg                                             324


<210>  7
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM7h-8 Amino acid-sequence

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Asn Ser Pro Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Arg Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-14 Nucleotide-sequence

<400>  8
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gggcaagtca gtggattggg tctcagttat cttggtacca gcagaaacca      120

gggaaagccc ctaagctcct gatcatgtgg cgttcctcgt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg ctacgtacta ctgtgctcag ggtgcggcgt tgcctaggac gttcggccaa      300

gggaccaagg tggaaatcaa acgg                                             324


<210>  9
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM7h-14 Amino acid-sequence

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  10
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 Q38 Primer


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  k is g or t

<400>  10
gcagctattt aaattggtat cagnnkaaac cagggaaagc ccc                         43


<210>  11
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 Q38 Primer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<400>  11
ggggctttcc ctggtttmnn ctgataccaa tttaaatagc tgc                         43


<210>  12
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 A43 Primer


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  k is g or t

<400>  12
cagcagaaac cagggaaann kcctaagctc ctgatctatc gg                          42


<210>  13
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 A43 Primer


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  13
ccgatagatc aggagcttag gmnntttccc tggtttctgc tg                          42


<210>  14
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 P44 Primer


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  k is g or t

<400>  14
cagcagaaac cagggaaagc cnnkaagctc ctgatctatc ggaattccc                   49


<210>  15
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 P44 Primer


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<400>  15
gggaattccg atagatcagg agcttmnngg ctttccctgg tttctgctg                   49


<210>  16
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-8 DOM8 Primer

<400>  16
agcggataac aatttcacac agga                                              24


<210>  17
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Q38C DOM7h-8 Primer

<400>  17
gcagctattt aaattggtat cagtgcaaac cagggaaagc ccc                         43


<210>  18
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Q38C DOM7h-8 Primer

<400>  18
ggggctttcc ctggtttgca ctgataccaa tttaaatagc tgc                         43


<210>  19
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Q38K DOM7h-8 Primer

<400>  19
gcagctattt aaattggtat cagaaaaaac cagggaaagc ccc                         43


<210>  20
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Q38K DOM7h-8 Primer

<400>  20
ggggctttcc ctggtttttt ctgataccaa tttaaatagc tgc                         43


<210>  21
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  A43N DOM7h-8 Primer

<400>  21
ggtatcagca gaaaccaggg aaaaacccta agctcctgat ctatcgg                     47


<210>  22
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  A43N DOM7h-8 Primer

<400>  22
ccgatagatc aggagcttag ggtttttccc tggtttctgc tgatacc                     47


<210>  23
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-8 Primer

<400>  23
cagcagaaac cagggaaaga tcctaagctc ctgatctatc                             40


<210>  24
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-8 Primer

<400>  24
gatagatcag gagcttagga tctttccctg gtttctgctg                             40


<210>  25
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  A43C DOM7h-8 Primer

<400>  25
ggtatcagca gaaaccaggg aaatgcccta agctcctgat ctatcgg                     47


<210>  26
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  A43C DOM7h-8 Primer

<400>  26
ccgatagatc aggagcttag ggcatttccc tggtttctgc tgatacc                     47


<210>  27
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  A43I DOM7h-8 Primer

<400>  27
ggtatcagca gaaaccaggg aaaattccta agctcctgat ctatcgg                     47


<210>  28
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  A43I DOM7h-8 Primer

<400>  28
ccgatagatc aggagcttag gaattttccc tggtttctgc tgatacc                     47


<210>  29
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44C DOM7h-8 Primer

<400>  29
cagcagaaac cagggaaagc ctgcaagctc ctgatctatc ggaattccc                   49


<210>  30
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44C DOM7h-8 Primer

<400>  30
gggaattccg atagatcagg agcttgcagg ctttccctgg tttctgctg                   49


<210>  31
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44E DOM7h-8 Primer

<400>  31
cagcagaaac cagggaaagc cgaaaagctc ctgatctatc ggaattccc                   49


<210>  32
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44E DOM7h-8 Primer

<400>  32
cagcagaaac cagggaaagc cgaaaagctc ctgatctatc ggaattccc                   49


<210>  33
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44T DOM7h-8 Primer

<400>  33
cagcagaaac cagggaaagc caccaagctc ctgatctatc ggaattccc                   49


<210>  34
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44T DOM7h-8 Primer

<400>  34
gggaattccg atagatcagg agcttggtgg ctttccctgg tttctgctg                   49


<210>  35
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44W DOM7h-8 Primer

<400>  35
cagcagaaac cagggaaagc ctggaagctc ctgatctatc ggaattccc                   49


<210>  36
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  P44W DOM7h-8 Primer

<400>  36
gggaattccg atagatcagg agcttccagg ctttccctgg tttctgctg                   49


<210>  37
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  DOM 7h-14 Q38 Primer


<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  k is g or t

<400>  37
gggtctcagt tatcttggta ccagnnkaaa ccagggaaag cccc                        44


<210>  38
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  DOM 7h-14 Q38 Primer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<400>  38
ggggctttcc ctggtttmnn ctggtaccaa gataactgag accc                        44


<210>  39
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  DOM 7h-14 A43 Primer


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  k is g or t

<400>  39
cagcagaaac cagggaaann kcctaagctc ctgatcatgt gg                          42


<210>  40
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  DOM 7h-14 A43 Primer


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  40
ccacatgatc aggagcttag gmnntttccc tggtttctgc tg                          42


<210>  41
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  DOM 7h-14 P44 Primer


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  k is g or t

<400>  41
cagcagaaac cagggaaagc cnnkaagctc ctgatcatgt ggcgttcc                    48


<210>  42
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  DOM 7h-14 P44 Primer


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  42
ggaacgccac atgatcagga gcttmnnggc tttccctggt ttctgctg                    48


<210>  43
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-14 Primer

<400>  43
cagcagaaac cagggaaaga tcctaagctc ctgatcatgt gg                          42


<210>  44
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-14 Primer

<400>  44
ccacatgatc aggagcttag gatctttccc tggtttctgc tg                          42


<210>  45
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  A43E DOM7h-14 Primer

<400>  45
cagcagaaac cagggaaaga acctaagctc ctgatcatgt gg                          42


<210>  46
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  A43E DOM7h-14 Primer

<400>  46
ccacatgatc aggagcttag gttctttccc tggtttctgc tg                          42


<210>  47
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44Q DOM7h-14 Primer

<400>  47
cagcagaaac cagggaaagc ccagaagctc ctgatcatgt ggcgttcc                    48


<210>  48
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44Q DOM7h-14 Primer

<400>  48
ggaacgccac atgatcagga gcttctgggc tttccctggt ttctgctg                    48


<210>  49
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44I DOM7h-14 Primer

<400>  49
cagcagaaac cagggaaagc cattaagctc ctgatcatgt ggcgttcc                    48


<210>  50
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44I DOM7h-14 Primer

<400>  50
ggaacgccac atgatcagga gcttaatggc tttccctggt ttctgctg                    48


<210>  51
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44M DOM7h-14 Primer

<400>  51
cagcagaaac cagggaaagc catgaagctc ctgatcatgt ggcgttcc                    48


<210>  52
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44M DOM7h-14 Primer

<400>  52
ggaacgccac atgatcagga gcttcatggc tttccctggt ttctgctg                    48


<210>  53
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44F DOM7h-14 Primer

<400>  53
cagcagaaac cagggaaagc ctttaagctc ctgatcatgt ggcgttcc                    48


<210>  54
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44F DOM7h-14 Primer

<400>  54
ggaacgccac atgatcagga gcttaaaggc tttccctggt ttctgctg                    48


<210>  55
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44W DOM7h-14 Primer

<400>  55
cagcagaaac cagggaaagc ctggaagctc ctgatcatgt ggcgttcc                    48


<210>  56
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  P44W DOM7h-14 Primer

<400>  56
ggaacgccac atgatcagga gcttccaggc tttccctggt ttctgctg                    48


<210>  57
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  pDOM5 Primer


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  k is g or t

<400>  57
gcagaaacca gggaaagccn nkaagctcct gatctatagt gc                          42


<210>  58
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  pDOM5 Primer


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<400>  58
gcactataga tcaggagctt mnnggctttc cctggtttct gc                          42


<210>  59
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  A43A_fwd Primer

<400>  59
gcagaaacca gggaaagccc ctaagctcct gatc                                   34


<210>  60
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  A43A_rev Primer

<400>  60
gatcaggagc ttaggggctt tccctggttt ctgc                                   34


<210>  61
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  A43D_fwd Primer

<400>  61
gcagaaacca gggaaagacc ctaagctcct gatc                                   34


<210>  62
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  A43D_rev Primer

<400>  62
gatcaggagc ttagggtctt tccctggttt ctgc                                   34


<210>  63
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  A43K_fwd Primer

<400>  63
aaattggtac cagcagaaac cagggaaaaa gcctaagctc ctgatc                      46


<210>  64
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  A43K_rev Primer

<400>  64
gatcaggagc ttaggctttt tccctggttt ctgctggtac caattt                      46


<210>  65
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  A43R_fwd Primer

<400>  65
gtaccagcag aaaccaggga aacggcctaa gctcctg                                37


<210>  66
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  A43R_rev Primer

<400>  66
caggagctta ggccgtttcc ctggtttctg ctggtac                                37


<210>  67
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  A43E_fwd Primer

<400>  67
cagcagaaac cagggaaaga gcctaagctc ctgatctatg                             40


<210>  68
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  A43E_rev Primer

<400>  68
catagatcag gagcttaggc tctttccctg gtttctgctg                             40


<210>  69
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  A43I_fwd Primer

<400>  69
ggtaccagca gaaaccaggg aaaatcccta agctcct                                37


<210>  70
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  A43I_rev Primer

<400>  70
aggagcttag ggattttccc tggtttctgc tggtacc                                37


<210>  71
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  A43L_fwd Primer

<400>  71
tggtaccagc agaaaccagg gaaactgcct aagctcctga                             40


<210>  72
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  A43L_rev Primer

<400>  72
tcaggagctt aggcagtttc cctggtttct gctggtacca                             40


<210>  73
<211>  444
<212>  DNA
<213>  Artificial

<220>
<223>  DOM4-130-54 Nucleotide sequence

<400>  73
atgttattta aatcattatc aaaattagca accgcagcag cattttttgc aggcgtggca       60

acagcgtcga cggacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga      120

gaccgtgtca ccatcacttg ccgggcaagt caggatattt acctgaattt agactggtat      180

cagcagaaac cagggaaagc ccctaagctc ctgatcaatt ttggttccga gttgcaaagt      240

ggtgtcccat cacgtttcag tggcagtgga tatgggacag atttcactct caccatcagc      300

agtctgcaac ctgaagattt cgctacgtac tactgtcaac cgtcttttta cttcccttat      360

acgttcggcc aagggaccaa ggtggaaatc aaacgggcgg ccgcagaaca aaaactcatc      420

tcagaagagg atctgaatta ataa                                             444


<210>  74
<211>  133
<212>  PRT
<213>  Artificial

<220>
<223>  DOM4-130-54 Amino Acid sequence

<400>  74

Met Leu Phe Lys Ser Leu Ser Lys Leu Ala Thr Ala Ala Ala Phe Phe 
1               5                   10                  15      


Ala Gly Val Ala Thr Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Tyr Leu Asn Leu Asp Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Asn Phe Gly Ser Glu Leu Gln Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Pro Ser Phe Tyr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Ala 
    130             


<210>  75
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  DOM9 Primer

<400>  75
cgccagggtt ttcccagtca cgac                                              24


<210>  76
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36 DOM7h-8 Primer


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  k is g or t

<400>  76
gcagctattt aaattggnnk cagcagaaac cagggaaagc ccctaag                     47


<210>  77
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36 DOM7h-8 Primer


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  77
cttaggggct ttccctggtt tctgctgmnn ccaatttaaa tagctgc                     47


<210>  78
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  L46 DOM7h-8 Primer


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  k is g or t

<400>  78
ccagggaaag cccctaagnn kctgatctat cggaattccc ctttg                       45


<210>  79
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  L46 DOM7h-8 Primer


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  79
caaaggggaa ttccgataga tcagmnnctt aggggctttc cctgg                       45


<210>  80
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87 DOM7h-8 Primer


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  k is g or t

<400>  80
cctgaagatt ttgctacgta cnnktgtcaa cagacgtata g                           41


<210>  81
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87 DOM7h-8 Primer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<400>  81
ctatacgtct gttgacamnn gtacgtagca aaatcttcag g                           41


<210>  82
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87C DOM7h-8 Primer

<400>  82
cctgaagatt ttgctacgta ctgctgtcaa cagacgtata g                           41


<210>  83
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87C DOM7h-8 Primer

<400>  83
ctatacgtct gttgacagca gtacgtagca aaatcttcag g                           41


<210>  84
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87E DOM7h-8 Primer

<400>  84
cctgaagatt ttgctacgta cgaatgtcaa cagacgtata g                           41


<210>  85
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87E DOM7h-8 Primer

<400>  85
ctatacgtct gttgacattc gtacgtagca aaatcttcag g                           41


<210>  86
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87N DOM7h-8 Primer

<400>  86
cctgaagatt ttgctacgta caactgtcaa cagacgtata g                           41


<210>  87
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87N DOM7h-8 Primer

<400>  87
ctatacgtct gttgacagtt gtacgtagca aaatcttcag g                           41


<210>  88
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87D DOM7h-8 Primer

<400>  88
cctgaagatt ttgctacgta cgattgtcaa cagacgtata g                           41


<210>  89
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87D DOM7h-8 Primer

<400>  89
ctatacgtct gttgacaatc gtacgtagca aaatcttcag g                           41


<210>  90
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87K DOM7h-8 Primer

<400>  90
cctgaagatt ttgctacgta caaatgtcaa cagacgtata g                           41


<210>  91
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87K DOM7h-8 Primer

<400>  91
ctatacgtct gttgacattt gtacgtagca aaatcttcag g                           41


<210>  92
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87P DOM7h-8 Primer

<400>  92
cctgaagatt ttgctacgta cccatgtcaa cagacgtata g                           41


<210>  93
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Y87P DOM7h-8 Primer

<400>  93
ctatacgtct gttgacacgg gtacgtagca aaatcttcag g                           41


<210>  94
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  L46C DOM7h-8 Primer

<400>  94
ccagggaaag cccctaagtg cctgatctat cggaattccc ctttg                       45


<210>  95
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  L46C DOM7h-8 Primer

<400>  95
caaaggggaa ttccgataga tcaggcactt aggggctttc cctgg                       45


<210>  96
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36D DOM7h-8 Primer

<400>  96
gcagctattt aaattgggat cagcagaaac cagggaaagc ccctaag                     47


<210>  97
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36D DOM7h-8 Primer

<400>  97
cttaggggct ttccctggtt tctgctgatc ccaatttaaa tagctgc                     47


<210>  98
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36N DOM7h-8 Primer

<400>  98
gcagctattt aaattggaac cagcagaaac cagggaaagc ccctaag                     47


<210>  99
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36N DOM7h-8 Primer

<400>  99
cttaggggct ttccctggtt tctgctggtt ccaatttaaa tagctgc                     47


<210>  100
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36M DOM7h-8 Primer

<400>  100
gcagctattt aaattggatg cagcagaaac cagggaaagc ccctaag                     47


<210>  101
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Y36M DOM7h-8 Primer

<400>  101
cttaggggct ttccctggtt tctgctgcat ccaatttaaa tagctgc                     47


<210>  102
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43I DOM7h-11-15 Primer

<400>  102
cagcagaaac cagggaaaat tcctaagctc ctgatcctt                              39


<210>  103
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43I DOM7h-11-15 Primer

<400>  103
aaggatcagg agcttaggaa ttttccctgg tttctgctg                              39


<210>  104
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-11-15 Primer

<400>  104
cagcagaaac cagggaaaga tcctaagctc ctgatcctt                              39


<210>  105
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-11-15 Primer

<400>  105
aaggatcagg agcttaggat ctttccctgg tttctgctg                              39


<210>  106
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-11-15 dAb

<400>  106
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca      120

gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa      300

gggaccaagg tggaaatcaa acgg                                             324


<210>  107
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM7h-11-15 dAb

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  108
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43I DOM7h-14-10 Primer

<400>  108
cagcagaaac cagggaaaat tcctaagctc ctgatcatg                              39


<210>  109
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43I DOM7h-14-10 Primer

<400>  109
catgatcagg agcttaggaa ttttccctgg tttctgctg                              39


<210>  110
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-14-10 Primer

<400>  110
cagcagaaac cagggaaaga tcctaagctc ctgatcatg                              39


<210>  111
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  A43D DOM7h-14-10 Primer

<400>  111
catgatcagg agcttaggat ctttccctgg tttctgctg                              39


<210>  112
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  DOM7h-14-10 dAb

<400>  112
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gggcaagtca gtggattggg tctcagttat cttggtacca gcagaaacca      120

gggaaagccc ctaagctcct gatcatgtgg cgttcctcgt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg ctacgtacta ctgtgctcag ggtttgaggc atcctaagac gttcggccaa      300

gggaccaagg tggaaatcaa acgg                                             324


<210>  113
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  DOM7h-14-10 dAb

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Leu Arg His Pro Lys 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


