                         SEQUENCE LISTING

<110>  Esoterix Genetic Laboratories, LLC
       Yang, Hai-Su
       Horten, Bruce
       Scholl, Thomas
 
<120>  Methods for Detecting Tumor Origin Based on MUC1, MUC2, and CK-17
        Expression Levels

<130>  57618-803405

<150>  US 61/324,618
<151>  2010-04-15

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  3343
<212>  DNA
<213>  Homo sapiens

<400>  1
gagctcctgg ccagtggtgg agagtggcaa ggaaggaccc tagggttcat cggagcccag       60

gtttactccc ttaagtggaa atttcttccc ccactcccct ccttggcttt ctccaaggag      120

ggaaccccag gctgctggaa agtccggctg gggcggggac tgtgggtttc agggtagaac      180

tgcgtgtgga acgggacagg gagcggttag aagggtgggg ctattccggg aagtggtggt      240

ggggggaggg agcccaaaac tagcacctag tccactcatt atccagccct cttatttctc      300

ggccgcctct gcttcagtgg acccggggag ggcggggaag tggagtggga gacctagggg      360

tgggcttccc gaccttgctg tacaggacct cgacctagct ggctttgttc cccatcccca      420

gttagttgtt gccctgaggc taaaactaga gcccaggggc cccaagttcc agactgcccc      480

tcccccctcc cccggagcca gggagtggtt ggtgaaaggg ggaggccagc tggagaagaa      540

acgggtagtc aggggttgca gcattagagc ccttgtagcc ctagcccagg aatggttgga      600

gagagaagag tagagtaggg aggggggttt gtcacctgtc acctgctcgg ctgtgcctag      660

ggcgggcggg ggggagtggg gggaccggta taaagcggta ggcgcctgtg cccgctccac      720

ctctcaagca gccagcgcct gcctgaatct gttctgcccc ctccccaccc atttcaccac      780

caccatgaca ccgggcaccc agtctccttt cttcctgctg ctgctcctca cagtgcttac      840

aggtgagggg cacgaggtgg ggagtgggct gccctgctta ggtggtcttc gtggtctttc      900

tgtgggtttt gctccctggc agatggcacc agaagttaag gtaagaattg cagacagagg      960

ctgccctgtc tgtgccagaa ggagggagag gctaaggaca ggctgagaag agttgccccc     1020

aaccctgaga gtgggtacca ggggcaagca aatgtcctgt agagaagtct agggggaaga     1080

gagtagggag agggaaggct taagagggga agaaatgcag gggccatgag ccaaggccta     1140

tgggcagaga gaaggaggct gctgcaggaa ggaggcggcc aacccagggg ttactgaggc     1200

tgcccactcc ccagtcctcc tggtattatt tctctggtgg ccaggcttat attttcttct     1260

tgctcttatt tttccttcat aaagacccaa ccctatgact ttaacttctt acagctacca     1320

cagcccctgg gcccgcaaca gttgttacag gttctggtca tgcaagctct accccaggtg     1380

gagaaaagga gacttcggct acccagagaa gttcagtgcc cagctctact gagaagaatg     1440

ctgtgagtat gaccagcagc gtactctcca gccacagccc cggttcaggc tcctccacca     1500

ctcagggaca ggatgtcact ctggccccgg ccacggaacc agcttcaggt tcagctgcca     1560

cctggggaca ggatgtcacc tcggtcccag tcaccaggcc agccctgggc tccaccaccc     1620

cgccagccca cgatgtcacc tcagccccgg acaacaagcc agccccgggc tccaccgccc     1680

ccccagccca gggtgtcacc tcggccccgg agaccaggcc gcccccgggc tccaccgccc     1740

ccccagccca tggtgtcacc tcggcgccgg acaacaggcc cgccttggcg tccaccgccc     1800

ctccagtcca caatgtcacc tcggcctcag gctctgcatc aggctcagct tctactctgg     1860

tgcacaacgg cacctctgcc agggctacca caaccccagc cagcaagagc actccattct     1920

caattcccag ccaccactct gatactccta ccacccttgc cagccatagc accaagactg     1980

atgccagtag cactcaccat agcacggtac ctcctctcac ctcctccaat cacagcactt     2040

ctccccagtt gtctactggg gtctctttct ttttcctgtc ttttcacatt tcaaacctcc     2100

agtttaattc ctctctggaa gatcccagca ccgactacta ccaagagctg cagagagaca     2160

tttctgaaat ggtgagtatc ggcctttcct tccccatgct cccctgaagc agccatcaga     2220

actgtccaca ccctttgcat caagcctgag tcctttccct ctcaccccag tttttgcaga     2280

tttataaaca agggggtttt ctgggcctct ccaatattaa gttcaggtac agttctgggt     2340

gtggacccag tgtggtggtt ggaggggtgg gtggtggtca tgagccgtag ggagggactg     2400

gtgcacttaa ggttggggga agagtgctga gccagagctg ggacccgtgg ctgaagtgcc     2460

catttccctg tgaccaggcc aggatctgtg gtggtacaat tgactctggc cttccgagaa     2520

ggtaccatca atgtccacga cgtggagaca cagttcaatc agtataaaac ggaagcagcc     2580

tctcgatata acctgacgat ctcaagacgt cagcggtgag gctacttccc tgctgcagcc     2640

agcaccatgc cggggcccct ctccttccag tgtctgggtc cccgctcttt ccttagtgct     2700

ggcagcggga ggggcgcctc ctctgggaga ctgccctgac cactgctttt ccttttagtg     2760

agtgatgtgc catttccttt ctctgaccag tctggggctg gggtgccagg ctggggcatc     2820

gcgctgctgg tgctggtctg tgttctggtt gcgctggcca ttgtctatct cattgccttg     2880

gtgagtgcag tccctggccc tgatcagagc cccccggtag aaggcactcc atggcctgcc     2940

ataacctcct atctccccag gctgtctgtc agtgccgccg aaagaactac gggcagctgg     3000

acatctttcc agcccgggat acctaccatc ctatgagcga gtaccccacc taccacaccc     3060

atgggcgcta tgtgccccta gcagtaccga tcgtagcccc tatgagaagg tgagattggg     3120

ccccacaggc aggggaagca gagggtttgg ctgggcaagg attctgaagg gggtacttgg     3180

aaaacccaaa gagcttggaa gaggtgagaa gtggcgtgaa gtgagcaggg gagggctggc     3240

aaggatgagg ggcagaggtc agaggagttt tgggggacag gcctgggagg agactatgga     3300

agaaaggggc ccctcaaaag ggagtgcccc actgccagaa ttc                       3343


<210>  2
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala Gln Gly Val Thr Ser Ala Pro Glu Thr 
    130                 135                 140                 


Arg Pro Pro Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Asn Arg Pro Ala Leu Ala Ser Thr Ala Pro Pro Val His 
                165                 170                 175     


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
            180                 185                 190         


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
        195                 200                 205             


Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 
    210                 215                 220                 


Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 
225                 230                 235                 240 


Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 
                245                 250                 255     


Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 
            260                 265                 270         


Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 
        275                 280                 285             


Leu Gln Arg Asp Ile Ser Glu Met Val Ser Ile Gly Leu Ser Phe Pro 
    290                 295                 300                 


Met Leu Pro 
305         


<210>  3
<211>  3108
<212>  DNA
<213>  Homo sapiens

<400>  3
gggcccccca cccacacaag cacagcaccg attgctgagt tgaccacatc caatcctccg       60

cctgagtcct caacccctca gacctctcgg tccacctctt cccctctcac ggagtcaacc      120

acccttctga gtaccctacc acctgccatt gagatgacca gcacggcccc accctccaca      180

cccacggcac ccacgaccac gagcggaggc cacacactgt ctccaccgcc cagcaccacc      240

acgtcccctc caggcacccc cactcgcggt accacgaccg ggtcatcttc agcccccacc      300

cccagcactg tgcagacgac caccaccagt gcctggaccc caacgccgac cccactctcc      360

acacccagca tcatcaggac cacaggcctg aggccctacc cttcctctgt gcttatctgc      420

tgtgtcctga acgacaccta ctacgcacca ggtgaggagg tgtacaacgg cacatacgga      480

gacacctgtt atttcgtcaa ctgctcactg agctgtacgt tggagttcta taactggtcc      540

tgcccatcca cgccctcccc aacacccacg ccctccaagt cgacgcccac gccttccaag      600

ccatcgtcca cgccctccaa gccgacgccc ggcaccaagc cccccgagtg cccagacttt      660

gatcctccca gacaggagaa cgagacttgg tggctgtgcg actgcttcat ggccacgtgc      720

aagtacaaca acacggtgga gatcgtgaag gtggagtgtg agccgccgcc catgcccacc      780

tgctccaacg gcctccaacc cgtgcgcgtc gaggaccccg acggctgctg ctggcactgg      840

gagtgcgact gctactgcac gggctggggc gacccgcact atgtcacctt cgacggactc      900

tactacagct accagggcaa ctgcacctac gtgctggtgg aggagatcag cccctccgtg      960

gacaacttcg gagtttacat cgacaactac cactgcgatc ccaacgacaa ggtgtcctgt     1020

ccccgcaccc tcatcgtgcg ccacgagacc caggaggtgc tgatcaagac cgtgcatatg     1080

atgcccatgc aggtgcaggt gcaggtgaac aggcaggcgg tggcactgcc ctacaagaag     1140

tacgggctgg aggtgtacca gtctggcatc aactacgtgg tggacatccc cgagctgggt     1200

gtcctcgtct cctacaatgg cctgtccttc tccgtcaggc tgccctacca ccggtttggc     1260

aacaacacca agggccagtg tggcacctgc accaacacca cctccgacga ctgcattctg     1320

cccagcgggg agatcgtctc caactgtgag gctgcggctg accagtggct ggtgaacgac     1380

ccctccaagc cacactgccc ccacagcagc tccacgacca agcgcccggc cgtcactgtg     1440

cccgggggcg gtaaaacgac cccacacaag gactgcaccc catctcccct ctgccagctc     1500

atcaaggaca gcctgtttgc ccagtgccac gcactggtgc ccccgcagca ctactacgat     1560

gcctgcgtgt tcgacagctg cttcatgccg ggctcgagcc tggagtgcgc cagtctgcag     1620

gcctacgcag ccctctgtgc ccagcagaac atctgcctcg actggcggaa ccacacgcat     1680

ggggcctgct tggtggagtg cccatctcac agggagtacc aggcctgtgg ccctgcagaa     1740

gagcccacgt gcaaatccag ctcctcccag cagaacaaca cagtcctggt ggaaggctgc     1800

ttctgtcctg agggcaccat gaactacgct cctggctttg atgtctgcgt gaagacctgc     1860

ggctgtgtgg gacctgacaa tgtgcccaga gagtttgggg agcacttcga gttcgactgc     1920

aagaactgtg tctgcctgga gggtggaagt ggcatcatct gccaacccaa gaggtgcagc     1980

cagaagcccg ttacccactg cgtggaagac ggcacctacc tcgccacgga ggtcaaccct     2040

gccgacacct gctgcaacat taccgtctgc aagtgcaaca ccagcctgtg caaagagaag     2100

ccctccgtgt gcccgctggg attcgaagtg aagagcaaga tggtgcctgg aaggtgctgt     2160

cccttctact ggtgtgagtc caagggggtg tgtgttcacg ggaatgctga gtaccagccc     2220

ggttctccag tttattcctc caagtgccag gactgcgtgt gcacggacaa ggtggacaac     2280

aacaccctgc tcaacgtcat cgcctgcacc cacgtgccct gcaacacctc ctgcagccct     2340

ggcttcgaac tcatggaggc ccccggggag tgctgtaaga agtgtgaaca gacgcactgt     2400

atcatcaaac ggcccgacaa ccagcacgtc atcctgaagc ccggggactt caagagcgac     2460

ccgaagaaca actgcacatt cttcagctgc gtgaagatcc acaaccagct catctcgtcc     2520

gtctccaaca tcacctgccc caactttgat gccagcattt gcatcccggg ctccatcaca     2580

ttcatgccca atggatgctg caagacctgc acccctcgca atgagaccag ggtgccctgc     2640

tccaccgtcc ccgtcaccac ggaggtttcg tacgccggct gcaccaagac cgtcctcatg     2700

aatcattgct ccgggtcctg cgggacattt gtcatgtact cggccaaggc ccaggccctg     2760

gaccacagct gctcctgctg caaagaggag aaaaccagcc agcgtgaggt ggtcctgagc     2820

tgccccaatg gcggctcgct gacacacacc tacacccaca tcgagagctg ccagtgccag     2880

gacaccgtct gcgggctccc caccggcacc tcccgccggg cccggcgctc ccctaggcat     2940

ctggggagcg ggtgagcggg gtgggcacag cccccttcac tgccctcgac agctttacct     3000

cccccggacc ctctgagcct cctaagctcg gcttcctctc ttcagatatt tattgtctga     3060

gtctttgttc agtccttgct ttccaataat aaactcaggg ggacatgc                  3108


<210>  4
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Pro Pro Thr His Thr Ser Thr Ala Pro Ile Ala Glu Leu Thr Thr 
1               5                   10                  15      


Ser Asn Pro Pro Pro Glu Ser Ser Thr Pro Gln Thr Ser Arg Ser Thr 
            20                  25                  30          


Ser Ser Pro Leu Thr Glu Ser Thr Thr Leu Leu Ser Thr Leu Pro Pro 
        35                  40                  45              


Ala Ile Glu Met Thr Ser Thr Ala Pro Pro Ser Thr Pro Thr Ala Pro 
    50                  55                  60                  


Thr Thr Thr Ser Gly Gly His Thr Leu Ser Pro Pro Pro Ser Thr Thr 
65                  70                  75                  80  


Thr Ser Pro Pro Gly Thr Pro Thr Arg Gly Thr Thr Thr Gly Ser Ser 
                85                  90                  95      


Ser Ala Pro Thr Pro Ser Thr Val Gln Thr Thr Thr Thr Ser Ala Trp 
            100                 105                 110         


Thr Pro Thr Pro Thr Pro Leu Ser Thr Pro Ser Ile Ile Arg Thr Thr 
        115                 120                 125             


Gly Leu Arg Pro Tyr Pro Ser Ser Val Leu Ile Cys Cys Val Leu Asn 
    130                 135                 140                 


Asp Thr Tyr Tyr Ala Pro Gly Glu Glu Val Tyr Asn Gly Thr Tyr Gly 
145                 150                 155                 160 


Asp Thr Cys Tyr Phe Val Asn Cys Ser Leu Ser Cys Thr Leu Glu Phe 
                165                 170                 175     


Tyr Asn Trp Ser Cys Pro Ser Thr Pro Ser Pro Thr Pro Thr Pro Ser 
            180                 185                 190         


Lys Ser Thr Pro Thr Pro Ser Lys Pro Ser Ser Thr Pro Ser Lys Pro 
        195                 200                 205             


Thr Pro Gly Thr Lys Pro Pro Glu Cys Pro Asp Phe Asp Pro Pro Arg 
    210                 215                 220                 


Gln Glu Asn Glu Thr Trp Trp Leu Cys Asp Cys Phe Met Ala Thr Cys 
225                 230                 235                 240 


Lys Tyr Asn Asn Thr Val Glu Ile Val Lys Val Glu Cys Glu Pro Pro 
                245                 250                 255     


Pro Met Pro Thr Cys Ser Asn Gly Leu Gln Pro Val Arg Val Glu Asp 
            260                 265                 270         


Pro Asp Gly Cys Cys Trp His Trp Glu Cys Asp Cys Tyr Cys Thr Gly 
        275                 280                 285             


Trp Gly Asp Pro His Tyr Val Thr Phe Asp Gly Leu Tyr Tyr Ser Tyr 
    290                 295                 300                 


Gln Gly Asn Cys Thr Tyr Val Leu Val Glu Glu Ile Ser Pro Ser Val 
305                 310                 315                 320 


Asp Asn Phe Gly Val Tyr Ile Asp Asn Tyr His Cys Asp Pro Asn Asp 
                325                 330                 335     


Lys Val Ser Cys Pro Arg Thr Leu Ile Val Arg His Glu Thr Gln Glu 
            340                 345                 350         


Val Leu Ile Lys Thr Val His Met Met Pro Met Gln Val Gln Val Gln 
        355                 360                 365             


Val Asn Arg Gln Ala Val Ala Leu Pro Tyr Lys Lys Tyr Gly Leu Glu 
    370                 375                 380                 


Val Tyr Gln Ser Gly Ile Asn Tyr Val Val Asp Ile Pro Glu Leu Gly 
385                 390                 395                 400 


Val Leu Val Ser Tyr Asn Gly Leu Ser Phe Ser Val Arg Leu Pro Tyr 
                405                 410                 415     


His Arg Phe Gly Asn Asn Thr Lys Gly Gln Cys Gly Thr Cys Thr Asn 
            420                 425                 430         


Thr Thr Ser Asp Asp Cys Ile Leu Pro Ser Gly Glu Ile Val Ser Asn 
        435                 440                 445             


Cys Glu Ala Ala Ala Asp Gln Trp Leu Val Asn Asp Pro Ser Lys Pro 
    450                 455                 460                 


His Cys Pro His Ser Ser Ser Thr Thr Lys Arg Pro Ala Val Thr Val 
465                 470                 475                 480 


Pro Gly Gly Gly Lys Thr Thr Pro His Lys Asp Cys Thr Pro Ser Pro 
                485                 490                 495     


Leu Cys Gln Leu Ile Lys Asp Ser Leu Phe Ala Gln Cys His Ala Leu 
            500                 505                 510         


Val Pro Pro Gln His Tyr Tyr Asp Ala Cys Val Phe Asp Ser Cys Phe 
        515                 520                 525             


Met Pro Gly Ser Ser Leu Glu Cys Ala Ser Leu Gln Ala Tyr Ala Ala 
    530                 535                 540                 


Leu Cys Ala Gln Gln Asn Ile Cys Leu Asp Trp Arg Asn His Thr His 
545                 550                 555                 560 


Gly Ala Cys Leu Val Glu Cys Pro Ser His Arg Glu Tyr Gln Ala Cys 
                565                 570                 575     


Gly Pro Ala Glu Glu Pro Thr Cys Lys Ser Ser Ser Ser Gln Gln Asn 
            580                 585                 590         


Asn Thr Val Leu Val Glu Gly Cys Phe Cys Pro Glu Gly Thr Met Asn 
        595                 600                 605             


Tyr Ala Pro Gly Phe Asp Val Cys Val Lys Thr Cys Gly Cys Val Gly 
    610                 615                 620                 


Pro Asp Asn Val Pro Arg Glu Phe Gly Glu His Phe Glu Phe Asp Cys 
625                 630                 635                 640 


Lys Asn Cys Val Cys Leu Glu Gly Gly Ser Gly Ile Ile Cys Gln Pro 
                645                 650                 655     


Lys Arg Cys Ser Gln Lys Pro Val Thr His Cys Val Glu Asp Gly Thr 
            660                 665                 670         


Tyr Leu Ala Thr Glu Val Asn Pro Ala Asp Thr Cys Cys Asn Ile Thr 
        675                 680                 685             


Val Cys Lys Cys Asn Thr Ser Leu Cys Lys Glu Lys Pro Ser Val Cys 
    690                 695                 700                 


Pro Leu Gly Phe Glu Val Lys Ser Lys Met Val Pro Gly Arg Cys Cys 
705                 710                 715                 720 


Pro Phe Tyr Trp Cys Glu Ser Lys Gly Val Cys Val His Gly Asn Ala 
                725                 730                 735     


Glu Tyr Gln Pro Gly Ser Pro Val Tyr Ser Ser Lys Cys Gln Asp Cys 
            740                 745                 750         


Val Cys Thr Asp Lys Val Asp Asn Asn Thr Leu Leu Asn Val Ile Ala 
        755                 760                 765             


Cys Thr His Val Pro Cys Asn Thr Ser Cys Ser Pro Gly Phe Glu Leu 
    770                 775                 780                 


Met Glu Ala Pro Gly Glu Cys Cys Lys Lys Cys Glu Gln Thr His Cys 
785                 790                 795                 800 


Ile Ile Lys Arg Pro Asp Asn Gln His Val Ile Leu Lys Pro Gly Asp 
                805                 810                 815     


Phe Lys Ser Asp Pro Lys Asn Asn Cys Thr Phe Phe Ser Cys Val Lys 
            820                 825                 830         


Ile His Asn Gln Leu Ile Ser Ser Val Ser Asn Ile Thr Cys Pro Asn 
        835                 840                 845             


Phe Asp Ala Ser Ile Cys Ile Pro Gly Ser Ile Thr Phe Met Pro Asn 
    850                 855                 860                 


Gly Cys Cys Lys Thr Cys Thr Pro Arg Asn Glu Thr Arg Val Pro Cys 
865                 870                 875                 880 


Ser Thr Val Pro Val Thr Thr Glu Val Ser Tyr Ala Gly Cys Thr Lys 
                885                 890                 895     


Thr Val Leu Met Asn His Cys Ser Gly Ser Cys Gly Thr Phe Val Met 
            900                 905                 910         


Tyr Ser Ala Lys Ala Gln Ala Leu Asp His Ser Cys Ser Cys Cys Lys 
        915                 920                 925             


Glu Glu Lys Thr Ser Gln Arg Glu Val Val Leu Ser Cys Pro Asn Gly 
    930                 935                 940                 


Gly Ser Leu Thr His Thr Tyr Thr His Ile Glu Ser Cys Gln Cys Gln 
945                 950                 955                 960 


Asp Thr Val Cys Gly Leu Pro Thr Gly Thr Ser Arg Arg Ala Arg Arg 
                965                 970                 975     


Ser Pro Arg His Leu Gly Ser Gly 
            980                 


<210>  5
<211>  1574
<212>  DNA
<213>  Homo sapiens

<400>  5
atcgctacgc ccacttggtg gcctataaag gaagcgggcg aaccccggca gccctacaca       60

acttggggcc cctctcctct ccagcccttc tcctgtgtgc ctgcctcctg ccgccgccac      120

catgaccacc tccatccgcc agttcacctc ctccagctcc atcaagggct cctccggcct      180

ggggggcggc tcgtcccgca cctcctgccg gctgtctggc ggcctgggtg ccggctcctg      240

caggctggga tctgctggcg gcctgggcag caccctcggg ggtagcagct actccagctg      300

ctacagcttt ggctctggtg gtggctatgg cagcagcttt gggggtgttg atgggctgct      360

ggctggaggt gagaaggcca ccatgcagaa cctcaatgac cgcctggcct cctacctgga      420

caaggtgcgt gccctggagg aggccaacac tgagctggag gtgaagatcc gtgactggta      480

ccagaggcag gccccggggc ccgcccgtga ctacagccag tactacagga caattgagga      540

gctgcagaac aagatcctca cagccaccgt ggacaatgcc aacatcctgc tacagattga      600

caatgcccgt ctggctgctg atgacttccg caccaagttt gagacagagc aggccctgcg      660

cctgagtgtg gaggccgaca tcaatggcct gcgcagggtg ctggatgagc tgaccctggc      720

cagagccgac ctggagatgc agattgagaa cctcaaggag gagctggcct acctgaagaa      780

gaaccacgag gaggagatga acgccctgcg aggccaggtg ggtggtgaga tcaatgtgga      840

gatggacgct gccccaggcg tggacctgag ccgcatcctc aacgagatgc gtgaccagta      900

tgagaagatg gcagagaaga accgcaagga tgccgaggat tggttcttca gcaagacaga      960

ggaactgaac cgcgaggtgg ccaccaacag tgagctggtg cagagtggca agagtgagat     1020

ctcggagctc cggcgcacca tgcaggcctt ggagatagag ctgcagtccc agctcagcat     1080

gaaagcatcc ctggagggca acctggcgga gacagagaac cgctactgcg tgcagctgtc     1140

ccagatccag gggctgattg gcagcgtgga ggagcagctg gcccagcttc gctgcgagat     1200

ggagcagcag aaccaggaat acaaaatcct gctggatgtg aagacgcggc tggagcagga     1260

gattgccacc taccgccgcc tgctggaggg agaggatgcc cacctgactc agtacaagaa     1320

agaaccggtg accacccgtc aggtgcgtac cattgtggaa gaggtccagg atggcaaggt     1380

catctcctcc cgcgagcagg tccaccagac cacccgctga ggactcagct accccggccg     1440

gccacccagg aggcagggag gcagccgccc catctgcccc acagtctccg gcctctccag     1500

cctcagcccc ctgcttcagt cccttcccca tgcttccttg cctgatgaca ataaagcttg     1560

ttgactcagc tatg                                                       1574


<210>  6
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Thr Ser Ile Arg Gln Phe Thr Ser Ser Ser Ser Ile Lys Gly 
1               5                   10                  15      


Ser Ser Gly Leu Gly Gly Gly Ser Ser Arg Thr Ser Cys Arg Leu Ser 
            20                  25                  30          


Gly Gly Leu Gly Ala Gly Ser Cys Arg Leu Gly Ser Ala Gly Gly Leu 
        35                  40                  45              


Gly Ser Thr Leu Gly Gly Ser Ser Tyr Ser Ser Cys Tyr Ser Phe Gly 
    50                  55                  60                  


Ser Gly Gly Gly Tyr Gly Ser Ser Phe Gly Gly Val Asp Gly Leu Leu 
65                  70                  75                  80  


Ala Gly Gly Glu Lys Ala Thr Met Gln Asn Leu Asn Asp Arg Leu Ala 
                85                  90                  95      


Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Thr Glu Leu 
            100                 105                 110         


Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Ala Pro Gly Pro Ala 
        115                 120                 125             


Arg Asp Tyr Ser Gln Tyr Tyr Arg Thr Ile Glu Glu Leu Gln Asn Lys 
    130                 135                 140                 


Ile Leu Thr Ala Thr Val Asp Asn Ala Asn Ile Leu Leu Gln Ile Asp 
145                 150                 155                 160 


Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu 
                165                 170                 175     


Gln Ala Leu Arg Leu Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg 
            180                 185                 190         


Val Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile 
        195                 200                 205             


Glu Asn Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu 
    210                 215                 220                 


Glu Met Asn Ala Leu Arg Gly Gln Val Gly Gly Glu Ile Asn Val Glu 
225                 230                 235                 240 


Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met 
                245                 250                 255     


Arg Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu 
            260                 265                 270         


Asp Trp Phe Phe Ser Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr 
        275                 280                 285             


Asn Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg 
    290                 295                 300                 


Arg Thr Met Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met 
305                 310                 315                 320 


Lys Ala Ser Leu Glu Gly Asn Leu Ala Glu Thr Glu Asn Arg Tyr Cys 
                325                 330                 335     


Val Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu Glu Gln 
            340                 345                 350         


Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys 
        355                 360                 365             


Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr 
    370                 375                 380                 


Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Thr Gln Tyr Lys Lys 
385                 390                 395                 400 


Glu Pro Val Thr Thr Arg Gln Val Arg Thr Ile Val Glu Glu Val Gln 
                405                 410                 415     


Asp Gly Lys Val Ile Ser Ser Arg Glu Gln Val His Gln Thr Thr Arg 
            420                 425                 430         


