
                                SEQUENCE LISTING

<110> SIRTRIS PHARMACEUTICALS, INC.
      STEIN, Ross L.
      DAI, Han
      RIERA, Thomas V.
      SZCZEPANKIEWICZ, Bruce G.

<120> SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS
  

<130> SIRT062

<140> PCT/US2011/032628   
<141> 2011-04-15  

<150> 61/324,579          
<151> 2010-04-15  

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> (1)...(1)

<220> 
<221> ACETYLATION    
<222> (4)...(4)

<220> 
<221> UNSURE         
<222> (4)...(4)
<223> 7-amido-4-methyl coumarin

<400> 1
Arg His Lys Lys
 1              


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<400> 2
Arg His Lys Lys Phe
 1               5  


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<400> 3
Arg His Lys Lys Trp
 1               5  


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<400> 4
Arg His Lys Lys Ala
 1               5  


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 12

<220> 
<221> MOD_RES        
<222> 13
<223> Nle

<220> 
<221> MOD_RES        
<222> 3
<223> biotin

<220> 
<221> MOD_RES        
<222> 18
<223> tetramethyl-6-carboxyrhodamine


<220> 
<221> AMIDATION      
<222> 20
<223> NH2

<400> 5
Glu Glu Lys Gly Gln Ser Thr Ser Ser His Ser Lys Leu Ser Thr Glu
 1               5                  10                  15      
Gly Lys Glu Glu
            20  


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 12

<220> 
<221> MOD_RES        
<222> 3
<223> biotin

<220> 
<221> MOD_RES        
<222> 13
<223> Nle

<220> 
<221> AMIDATION      
<222> 20
<223> NH2

<400> 6
Glu Glu Lys Gly Gln Ser Thr Ser Ser His Ser Lys Leu Ser Thr Glu
 1               5                  10                  15      
Gly Lys Glu Glu
            20  


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<220> 
<221> AMIDATION      
<222> 5
<223> NH2

<400> 7
Arg His Lys Lys Trp
 1               5  


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<220> 
<221> AMIDATION      
<222> 5
<223> NH2

<400> 8
Arg His Lys Lys Phe
 1               5  


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Any Amino Acid

<400> 9
Arg His Lys Lys Xaa
 1               5  


<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<220> 
<221> AMIDATION      
<222> 5
<223> NH2

<400> 10
Arg His Lys Lys Trp
 1               5  


<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<400> 11
Arg His Lys Lys
 1              


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<220> 
<221> AMIDATION      
<222> 5
<223> NH2

<400> 12
Arg His Lys Lys Phe
 1               5  


<210> 13
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> MOD_RES        
<222> 3
<223> biotin

<220> 
<221> ACETYLATION    
<222> 11

<220> 
<221> MOD_RES        
<222> (12)...(12)
<223> Nle

<220> 
<221> MOD_RES        
<222> 17
<223> tetramethyl-6-carboxyrhodamine

<400> 13
Glu Glu Lys Gly Gln Ser Thr Ser Ser His Lys Leu Ser Thr Glu Gly
 1               5                  10                  15      
Lys Glu Glu
            


<210> 14
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> MOD_RES        
<222> 3
<223> biotin

<220> 
<221> ACETYLATION    
<222> 11

<220> 
<221> MOD_RES        
<222> 12
<223> Nle

<400> 14
Glu Glu Lys Gly Gln Ser Thr Ser Ser His Lys Leu Ser Thr Glu Gly
 1               5                  10                  15      
Lys Glu Glu
            


<210> 15
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 11

<220> 
<221> MOD_RES        
<222> 12
<223> Nle

<400> 15
Glu Glu Lys Gly Gln Ser Thr Ser Ser His Lys Leu Ser Thr Glu Gly
 1               5                  10                  15      
Lys Glu Glu
            


<210> 16
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 12

<220> 
<221> MOD_RES        
<222> 14
<223> Nle

<400> 16
Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Leu Lys Thr
 1               5                  10                  15      
Glu Gly Pro
            


<210> 17
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 4

<220> 
<221> UNSURE         
<222> 4
<223> 7-amido-4-methyl coumarin

<400> 17
Arg His Lys Lys
 1              


<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 4

<400> 18
Arg His Lys Lys
 1              


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 4

<400> 19
Arg His Lys Lys Ala
 1               5  


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 4

<400> 20
Arg His Lys Lys Phe
 1               5  


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 4

<400> 21
Arg His Lys Lys Trp
 1               5  


<210> 22
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> P53 Artificial sequence

<220> 
<221> ACETYLATION    
<222> 1, 4

<220> 
<221> AMIDATION      
<222> 4
<223> NH2

<400> 22
Arg His Lys Lys
 1              

