
                                SEQUENCE LISTING

<110> Reed, Eddie
      Figg, William
      Gao, Rui

<120> PROGNOSTIC MARKERS AND METHODS FOR
  PROSTATE CANCER

<130> USA.003VPC

<150> 61/342,520          
<151> 2010-04-15  

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 20
<212> DNA
<213> Homo Sapien

<220> 
<223> ERCC1

<400> 1
tggatcagag gatcagggac                                             20

<210> 2
<211> 20
<212> DNA
<213> Homo Sapien

<220> 
<223> ERCC1

<400> 2
ttcctgagac ccaggagttc                                             20

<210> 3
<211> 24
<212> DNA
<213> Homo Sapien

<220> 
<223> XPD

<400> 3
ccttctcctg cgattaaagg ctgt                                        24

<210> 4
<211> 24
<212> DNA
<213> Homo Sapien

<220> 
<223> XPD

<400> 4
tcagccccat cttatgttga cagg                                        24

<210> 5
<211> 20
<212> DNA
<213> Homo Sapien

<220> 
<223> XRCC1

<400> 5
agacaaagat gaggcagagg                                             20

<210> 6
<211> 21
<212> DNA
<213> Homo Sapien

<220> 
<223> XRCC1

<400> 6
tcaaccctca ggacacaaga g                                           21

<210> 7
<211> 21
<212> DNA
<213> Homo Sapien

<220> 
<223> XRCC1

<400> 7
tgcatctctc ccttggtctc c                                           21

<210> 8
<211> 21
<212> DNA
<213> Homo Sapien

<220> 
<223> XRCC1

<400> 8
tgcacaaact gctcctccag c                                           21

<210> 9
<211> 22
<212> DNA
<213> Homo Sapien

<220> 
<223> PARP1

<400> 9
tcccaaatgt cagcatgtac ga                                          22

<210> 10
<211> 24
<212> DNA
<213> Homo Sapien

<220> 
<223> PARP1

<400> 10
tccaggagat cctaacacac atgg                                        24

<210> 11
<211> 21
<212> DNA
<213> Homo Sapien

<220> 
<223> PARP1

<400> 11
aggtaacagg ctggccctga c                                           21

<210> 12
<211> 22
<212> DNA
<213> Homo Sapien

<220> 
<223> PARP1

<400> 12
aggaaggcct gaccctgtta cc                                          22

<210> 13
<211> 3328
<212> DNA
<213> Homo Sapien

<220> 
<221> mRNA           
<222> (1)...(3328)
<223> ERCC1

<400> 13
ccggaagtgc tgcgagccct gggccacgct ggccgtgctg gcagtgggcc gcctcgatcc 60
ctctgcagtc tttcccttga ggctccaaga ccagcaggtg aggcctcgcg gcgctgaaac 120
cgtgaggccc ggaccacagg ctccagatgg accctgggaa ggacaaagag ggggtgcccc 180
agccctcagg gccgccagca aggaagaaat ttgtgatacc cctcgacgag gatgaggtcc 240
ctcctggagt ggccaagccc ttattccgat ctacacagag ccttcccact gtggacacct 300
cggcccaggc ggcccctcag acctacgccg aatatgccat ctcacagcct ctggaagggg 360
ctggggccac gtgccccaca gggtcagagc ccctggcagg agagacgccc aaccaggccc 420
tgaaacccgg ggcaaaatcc aacagcatca ttgtgagccc tcggcagagg ggcaatcccg 480
tactgaagtt cgtgcgcaat gtgccctggg aatttggcga cgtaattccc gactatgtgc 540
tgggccagag cacctgtgcc ctgttcctca gcctccgcta ccacaacctg cacccagact 600
acatccatgg gcggctgcag agcctgggga agaacttcgc cttgcgggtc ctgcttgtcc 660
aggtggatgt gaaagatccc cagcaggccc tcaaggagct ggctaagatg tgtatcctgg 720
ccgactgcac attgatcctc gcctggagcc ccgaggaagc tgggcggtac ctggagacct 780
acaaggccta tgagcagaaa ccagcggacc tcctgatgga gaagctagag caggacttcg 840
tctcccggtc tctggaacag ctcatcgccg catcaagaga agatctggcc ttatgcccag 900
gcctgggccc tcagaaagcc cggaggctgt ttgatgtcct gcacgagccc ttcttgaaag 960
taccctgatg accccagctg ccaaggaaac ccccagtgta ataataaatc gtcctcccag 1020
gccaggctcc tgctggctgc gctggtgcag tctctgggga gggattctgg gggtgtcacc 1080
ttctggtggc ccaggtgggc accttcagct ttctttagtt cctcagtttc ccgggggcag 1140
actacacagg ctgctgctgc tgctgcttcc gcttcttgtc ccggcctgtg ggagcctcct 1200
ccccagactc tgaattcagt ggcggccctg gcatctcctc ttggggcact gtctctggca 1260
tccggctttc ctgactctgc ttcttcctct tcttggtgga tcccggagtt gccctggctt 1320
caggctgtcc ctcccctggc agttcaggct ctagtggctg aattggctca gtcactgtgt 1380
gacctctctc tttcttcttc ttcttcttct tggtggatgt gggagctgcc tgaggctcaa 1440
ggtcatccgg cagctcaggc cccaccacct ctgtctctgg ctccactgtg gcatcttgct 1500
gtttttcttt cttcgtcttc tttttgggag ctgccagagc tgcctgggcc tgaggcttcg 1560
ctccttctgg ctgttgaggc gccatggtcc cccctgggga ctccagaggc ttcatctccg 1620
gctccactgg ctccatcgcc tccgtccctg gctccatcat tgccatctgt cccttttctt 1680
ttttcctctt cttcgtaggg ggcagaggga tggcttcctc cagtggctcc accttcacct 1740
gtggctgaga ctcaactgtc accccctcct ctggctccat cccttccgtc cccttttgcc 1800
tctttctctt tttggtcggg gacaggactg tgtcttctag aggctcagtg ttaatctgtt 1860
cctgcttcac tgtcttgtct tctggctcga aggtttcttt ccctttgggc ttcttcctct 1920
tcttggtggt ggacgggaac agcactccca gaggctccag tgtctccact gtgggctctg 1980
tccccacagg ccctgctgcc tctggttctt tcagctgctg attttttttc ttcttcttct 2040
tccgcacatc catttctggc gaccccaaag ccatgtccac ctccagggcc ccgtgcccat 2100
tcactgcctc ctgagtgact ggggcctctg tcacctgcat ctcctttttc ttcttccctg 2160
aggtgagcag gttgggggcc aaggctgacc taggccctgt gactggtggg ttgcccccaa 2220
aggcacagaa ccgaggcctc aggccaggag ggatctgtgg tgggggactt gctgggatgg 2280
gctgcagagg gctccctgac agggattgct ggggaccctc aaggatcctt agggtgccct 2340
ggggggctga ggcacaggtg agtccacctc ctgcctccgt tgagggggcc agcagggtcg 2400
cttctccagc ttggggacag ctgctgagga ctcgatagcg gtgccgcttg cctgccaatt 2460
tgcccttgac gatctgggag ccagagagag gcacatgccg cccattgaag ctacagagag 2520
aaacagggag ggcagaggct taagtggaac aggagaggga aggttttttg attttttttt 2580
tgtttttttt tgagagagtc ttgctctgtt gcctaggctg gagtgcagtg gcatgatctc 2640
ggctcactgc aatgtccacc tcctgggttc aagcgattct cctgcctcag cctctcaagt 2700
agctgggatt acaggcacct gccaccacgc ccagccaatt tttgtatttt tagtagagac 2760
aatttcacta tgttggccag gctggtcttg aactcctgac ctcaagtgat ctgctcgcct 2820
cggcctccca aaggatggga ttacaggcac cagccactgc gcctggctgg cctctggttt 2880
ttaataaaac atgactagag tgactccatc ttaaagtgag tagctaggca cttacaaggt 2940
tcatgcttat ggcctgaaaa taaccacatc ccaggctgac caccaattat aattacagaa 3000
tatttatggc catacagaac atgttccacc aagcctgcag aatgtccaaa tgtcctaaga 3060
atgcagcccc cattacttaa atataacata aatgagcaag cttaggttgc aggattaatg 3120
gtcgtggata acaccaatag cccctacctt tagtgagctt atctgcacac tccaagttta 3180
actatagttc cttatagttt cttataagta gaaatactaa caaagggctg tgggtttctc 3240
cccctgcttt ctgaggacac tctactctgt aaaggagtag tttccaataa acttgtttct 3300
ttcactgtgc aaaaaaaaaa aaaaaaaa                                    3328

<210> 14
<211> 273
<212> PRT
<213> Homo Sapien

<220> 
<221> PEPTIDE        
<222> (1)...(270)
<223> ERCC1

<400> 14
Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro
 1               5                  10                  15      
Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro
            20                  25                  30          
Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr
        35                  40                  45              
Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala
    50                  55                  60                  
Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser
65                  70                  75                  80  
Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala
                85                  90                  95      
Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val
            100                 105                 110         
Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro
        115                 120                 125             
Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg
    130                 135                 140                 
Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu
145                 150                 155                 160 
Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys
                165                 170                 175     
Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala
            180                 185                 190         
Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr
        195                 200                 205             
Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met
    210                 215                 220                 
Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Ser Leu Glu Gln Leu Ile
225                 230                 235                 240 
Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln
                245                 250                 255     
Lys Ala Arg Arg Leu Phe Asp Val Leu His Glu Pro Phe Leu Lys Val
            260                 265                 270         
Pro
    


<210> 15
<211> 2568
<212> DNA
<213> Homo Sapien

<220> 
<221> mRNA           
<222> (1)...(2568)
<223> XPD

<400> 15
ttcatgaggg aggcgggtcg accccgctgc acagtccggc cggcgccatg aagctcaacg 60
tggacgggct cctggtctac ttcccgtacg actacatcta ccccgagcag ttctcctaca 120
tgcgggagct caaacgcacg ctggacgcca agggtcatgg agtcctggag atgccctcag 180
gcaccgggaa gacagtatcc ctgttggccc tgatcatggc ataccagaga gcatatccgc 240
tggaggtgac caaactcatc tactgctcaa gaactgtgcc agagattgag aaggtgattg 300
aagagcttcg aaagttgctc aacttctatg agaagcagga gggcgagaag ctgccgtttc 360
tgggactggc tctgagctcc cgcaaaaact tgtgtattca ccctgaggtg acacccctgc 420
gctttgggaa ggacgtcgat gggaaatgcc acagcctcac agcctcctat gtgcgggcgc 480
agtaccagca tgacaccagc ctgccccact gccgattcta tgaggaattt gatgcccatg 540
ggcgtgaggt gcccctcccc gctggcatct acaacctgga tgacctgaag gccctggggc 600
ggcgccaggg ctggtgccca tacttccttg ctcgatactc aatcctgcat gccaatgtgg 660
tggtttatag ctaccactac ctcctggacc ccaagattgc agacctggtg tccaaggaac 720
tggcccgcaa ggccgtcgtg gtcttcgacg aggcccacaa cattgacaac gtctgcatcg 780
actccatgag cgtcaacctc acccgccgga cccttgaccg gtgccagggc aacctggaga 840
ccctgcagaa gacggtgctc aggatcaaag agacagacga gcagcgcctg cgggacgagt 900
accggcgtct ggtggagggg ctgcgggagg ccagcgccgc ccgggagacg gacgcccacc 960
tggccaaccc cgtgctgccc gacgaagtgc tgcaggaggc agtgcctggc tccatccgca 1020
cggccgagca tttcctgggc ttcctgaggc ggctgctgga gtacgtgaag tggcggctgc 1080
gtgtgcagca tgtggtgcag gagagcccgc ccgccttcct gagcggcctg gcccagcgcg 1140
tgtgcatcca gcgcaagccc ctcagattct gtgctgaacg cctccggtcc ctgctgcata 1200
ctctggagat caccgacctt gctgacttct ccccgctcac cctccttgct aactttgcca 1260
cccttgtcag cacctacgcc aaaggcttca ccatcatcat cgagcccttt gacgacagaa 1320
ccccgaccat tgccaacccc atcctgcact tcagctgcat ggacgcctcg ctggccatca 1380
aacccgtatt tgagcgtttc cagtctgtca tcatcacatc tgggacactg tccccgctgg 1440
acatctaccc caagatcctg gacttccacc ccgtcaccat ggcaaccttc accatgacgc 1500
tggcacgggt ctgcctctgc cctatgatca tcggccgtgg caatgaccag gtggccatca 1560
gctccaaatt tgagacccgg gaggatattg ctgtgatccg gaactatggg aacctcctgc 1620
tggagatgtc cgctgtggtc cctgatggca tcgtggcctt cttcaccagc taccagtaca 1680
tggagagcac cgtggcctcc tggtatgagc aggggatcct tgagaacatc cagaggaaca 1740
agctgctctt tattgagacc caggatggtg ccgaaaccag tgtcgccctg gagaagtacc 1800
aggaggcctg cgagaatggc cgcggggcca tcctgctgtc agtggcccgg ggcaaagtgt 1860
ccgagggaat cgactttgtg caccactacg ggcgggccgt catcatgttt ggcgtcccct 1920
acgtctacac acagagccgc attctcaagg cgcggctgga atacctgcgg gaccagttcc 1980
agattcgtga gaatgacttt cttaccttcg atgccatgcg ccacgcggcc cagtgtgtgg 2040
gtcgggccat caggggcaag acggactacg gcctcatggt ctttgccgac aagcggtttg 2100
cccgtgggga caagcggggg aagctgcccc gctggatcca ggagcacctc acagatgcca 2160
acctcaacct gaccgtggac gagggtgtcc aggtggccaa gtacttcctg cggcagatgg 2220
cacagccctt ccaccgggag gatcagctgg gcctgtccct gctcagcctg gagcagctag 2280
aatcagagga gacgctgaag aggatagagc agattgctca gcagctctga gtggggcggg 2340
tggggccata aacggttcct ggtgactcct gagtcttgcc tggccctggt tcccagcggc 2400
ggtggtgcta gaaggtctta tgaagtcagg tgacatttct cactgtcacg tccacagcct 2460
ttaatcgcag gagaaggcag ctatccacca ggtacccaga ggcaaggggg ggccaggaga 2520
tgatagaccc cctctcaccc caccagccca tccctcctgc actgttcc              2568

<210> 16
<211> 760
<212> PRT
<213> Homo Sapien

<220> 
<221> PEPTIDE        
<222> (1)...(760)
<223> XPD

<400> 16
Met Lys Leu Asn Val Asp Gly Leu Leu Val Tyr Phe Pro Tyr Asp Tyr
 1               5                  10                  15      
Ile Tyr Pro Glu Gln Phe Ser Tyr Met Arg Glu Leu Lys Arg Thr Leu
            20                  25                  30          
Asp Ala Lys Gly His Gly Val Leu Glu Met Pro Ser Gly Thr Gly Lys
        35                  40                  45              
Thr Val Ser Leu Leu Ala Leu Ile Met Ala Tyr Gln Arg Ala Tyr Pro
    50                  55                  60                  
Leu Glu Val Thr Lys Leu Ile Tyr Cys Ser Arg Thr Val Pro Glu Ile
65                  70                  75                  80  
Glu Lys Val Ile Glu Glu Leu Arg Lys Leu Leu Asn Phe Tyr Glu Lys
                85                  90                  95      
Gln Glu Gly Glu Lys Leu Pro Phe Leu Gly Leu Ala Leu Ser Ser Arg
            100                 105                 110         
Lys Asn Leu Cys Ile His Pro Glu Val Thr Pro Leu Arg Phe Gly Lys
        115                 120                 125             
Asp Val Asp Gly Lys Cys His Ser Leu Thr Ala Ser Tyr Val Arg Ala
    130                 135                 140                 
Gln Tyr Gln His Asp Thr Ser Leu Pro His Cys Arg Phe Tyr Glu Glu
145                 150                 155                 160 
Phe Asp Ala His Gly Arg Glu Val Pro Leu Pro Ala Gly Ile Tyr Asn
                165                 170                 175     
Leu Asp Asp Leu Lys Ala Leu Gly Arg Arg Gln Gly Trp Cys Pro Tyr
            180                 185                 190         
Phe Leu Ala Arg Tyr Ser Ile Leu His Ala Asn Val Val Val Tyr Ser
        195                 200                 205             
Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Asp Leu Val Ser Lys Glu
    210                 215                 220                 
Leu Ala Arg Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp
225                 230                 235                 240 
Asn Val Cys Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg Thr Leu
                245                 250                 255     
Asp Arg Cys Gln Gly Asn Leu Glu Thr Leu Gln Lys Thr Val Leu Arg
            260                 265                 270         
Ile Lys Glu Thr Asp Glu Gln Arg Leu Arg Asp Glu Tyr Arg Arg Leu
        275                 280                 285             
Val Glu Gly Leu Arg Glu Ala Ser Ala Ala Arg Glu Thr Asp Ala His
    290                 295                 300                 
Leu Ala Asn Pro Val Leu Pro Asp Glu Val Leu Gln Glu Ala Val Pro
305                 310                 315                 320 
Gly Ser Ile Arg Thr Ala Glu His Phe Leu Gly Phe Leu Arg Arg Leu
                325                 330                 335     
Leu Glu Tyr Val Lys Trp Arg Leu Arg Val Gln His Val Val Gln Glu
            340                 345                 350         
Ser Pro Pro Ala Phe Leu Ser Gly Leu Ala Gln Arg Val Cys Ile Gln
        355                 360                 365             
Arg Lys Pro Leu Arg Phe Cys Ala Glu Arg Leu Arg Ser Leu Leu His
    370                 375                 380                 
Thr Leu Glu Ile Thr Asp Leu Ala Asp Phe Ser Pro Leu Thr Leu Leu
385                 390                 395                 400 
Ala Asn Phe Ala Thr Leu Val Ser Thr Tyr Ala Lys Gly Phe Thr Ile
                405                 410                 415     
Ile Ile Glu Pro Phe Asp Asp Arg Thr Pro Thr Ile Ala Asn Pro Ile
            420                 425                 430         
Leu His Phe Ser Cys Met Asp Ala Ser Leu Ala Ile Lys Pro Val Phe
        435                 440                 445             
Glu Arg Phe Gln Ser Val Ile Ile Thr Ser Gly Thr Leu Ser Pro Leu
    450                 455                 460                 
Asp Ile Tyr Pro Lys Ile Leu Asp Phe His Pro Val Thr Met Ala Thr
465                 470                 475                 480 
Phe Thr Met Thr Leu Ala Arg Val Cys Leu Cys Pro Met Ile Ile Gly
                485                 490                 495     
Arg Gly Asn Asp Gln Val Ala Ile Ser Ser Lys Phe Glu Thr Arg Glu
            500                 505                 510         
Asp Ile Ala Val Ile Arg Asn Tyr Gly Asn Leu Leu Leu Glu Met Ser
        515                 520                 525             
Ala Val Val Pro Asp Gly Ile Val Ala Phe Phe Thr Ser Tyr Gln Tyr
    530                 535                 540                 
Met Glu Ser Thr Val Ala Ser Trp Tyr Glu Gln Gly Ile Leu Glu Asn
545                 550                 555                 560 
Ile Gln Arg Asn Lys Leu Leu Phe Ile Glu Thr Gln Asp Gly Ala Glu
                565                 570                 575     
Thr Ser Val Ala Leu Glu Lys Tyr Gln Glu Ala Cys Glu Asn Gly Arg
            580                 585                 590         
Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Ile
        595                 600                 605             
Asp Phe Val His His Tyr Gly Arg Ala Val Ile Met Phe Gly Val Pro
    610                 615                 620                 
Tyr Val Tyr Thr Gln Ser Arg Ile Leu Lys Ala Arg Leu Glu Tyr Leu
625                 630                 635                 640 
Arg Asp Gln Phe Gln Ile Arg Glu Asn Asp Phe Leu Thr Phe Asp Ala
                645                 650                 655     
Met Arg His Ala Ala Gln Cys Val Gly Arg Ala Ile Arg Gly Lys Thr
            660                 665                 670         
Asp Tyr Gly Leu Met Val Phe Ala Asp Lys Arg Phe Ala Arg Gly Asp
        675                 680                 685             
Lys Arg Gly Lys Leu Pro Arg Trp Ile Gln Glu His Leu Thr Asp Ala
    690                 695                 700                 
Asn Leu Asn Leu Thr Val Asp Glu Gly Val Gln Val Ala Lys Tyr Phe
705                 710                 715                 720 
Leu Arg Gln Met Ala Gln Pro Phe His Arg Glu Asp Gln Leu Gly Leu
                725                 730                 735     
Ser Leu Leu Ser Leu Glu Gln Leu Glu Ser Glu Glu Thr Leu Lys Arg
            740                 745                 750         
Ile Glu Gln Ile Ala Gln Gln Leu
        755                 760 


<210> 17
<211> 2102
<212> DNA
<213> Homo Sapien

<220> 
<223> XRCC1

<400> 17
ctcgcgcgct tgcgcacttt agccagcgca gggcgcaccc cgccccctcc cactctccct 60
gcccctcgga ccccatactc tacctcatcc ttctggccag gcgaagccca cgacgttgac 120
atgccggaga tccgcctccg ccatgtcgtg tcctgcagca gccaggactc gactcactgt 180
gcagaaaatc ttctcaaggc agacacttac cgaaaatggc gggcagccaa ggcaggcgag 240
aagaccatct ctgtggtcct acagttggag aaggaggagc agatacacag tgtggacatt 300
gggaatgatg gctcagcttt cgtggaggtg ctggtgggca gttcagctgg aggcgctggg 360
gagcaagact atgaggtcct tctggtcacc tcatctttca tgtccccttc cgagagccgc 420
agtggctcaa accccaaccg cgttcgcatg tttgggcctg acaagctggt ccgggcagcc 480
gccgagaagc gctgggaccg ggtcaaaatt gtttgcagcc agccctacag caaggactcc 540
ccctttggct tgagttttgt acggtttcat agccccccag acaaagatga ggcagaggcc 600
ccgtcccaga aggtgacagt gaccaagctt ggccagttcc gtgtgaagga ggaggatgag 660
agcgccaact ctctgaggcc gggggctctc ttcttcagcc ggatcaacaa gacatcccca 720
gtcacagcca gcgacccagc aggacctagc tatgcagctg ctaccctcca ggcttctagt 780
gctgcctcct cagcctctcc agtctccagg gccataggca gcacctccaa gccccaggag 840
tctcccaaag ggaagaggaa gttggatttg aaccaagaag aaaagaagac ccccagcaaa 900
ccaccagccc agctgtcgcc atctgttccc aagagaccta aattgccagc tccaactcgt 960
accccagcca cagccccagt ccctgcccga gcacaggggg cagtgacagg caaaccccga 1020
ggagaaggca ccgagcccag acgaccccga gctggcccag aggagctggg gaagatcctt 1080
cagggtgtgg tagtggtgct gagtggcttc cagaacccct tccgctccga gctgcgagat 1140
aaggccctag agcttggggc caagtatcgg ccagactgga cccgggacag cacgcacctc 1200
atctgtgcct ttgccaacac ccccaagtac agccaggtcc taggcctggg aggccgcatc 1260
gtgcgtaagg agtgggtgct ggactgtcac cgcatgcgtc ggcggctgcc ctcccagagg 1320
tacctcatgg cagggccagg ttccagcagt gaggaggatg aggcctctca cagcggtggc 1380
agcggagatg aagcccccaa gcttcctcag aagcaacccc agaccaaaac caagcccact 1440
caggcagctg gacccagctc accccagaag cccccaaccc ctgaagagac caaagcagcc 1500
tcaccagtgc tccaggaaga tatagacatt gagggggtac agtcagaagg acaggacaat 1560
ggggcggaag attctgggga cacagaggat gagctgagga gggtggcaga gcagaaggaa 1620
cacagactgc cccctggcca ggaggagaat ggggaagacc cgtatgcagg ctccacggat 1680
gagaacacgg acagtgagga acaccaggag cctcctgatc tgccagtccc tgagctccca 1740
gatttcttcc agggcaagca cttctttctt tacggggagt tccctgggga cgagcggcgg 1800
aaactcatcc gatacgtcac agccttcaat ggggagctcg aggactatat gagtgaccgg 1860
gttcagtttg tgatcacagc acaggaatgg gatcccagct ttgaggaggc cctgatggac 1920
aacccctccc tggcattcgt tcgtccccga tggatctaca gttgcaatga gaagcagaag 1980
ttacttcctc accagctcta tggggtggtg ccgcaagcct gaagtatgtg ctatacacac 2040
acacacacac acacacacac acacacacac acgatgcatt taataaagat gagttggttc 2100
tc                                                                2102

<210> 18
<211> 633
<212> PRT
<213> Homo Sapien

<220> 
<221> PEPTIDE        
<222> (1)...(630)
<223> XRCC1

<400> 18
Met Pro Glu Ile Arg Leu Arg His Val Val Ser Cys Ser Ser Gln Asp
 1               5                  10                  15      
Ser Thr His Cys Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg Lys
            20                  25                  30          
Trp Arg Ala Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu Gln
        35                  40                  45              
Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp Gly
    50                  55                  60                  
Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala Gly
65                  70                  75                  80  
Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met Ser Pro
                85                  90                  95      
Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Met Phe Gly
            100                 105                 110         
Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp Arg Val
        115                 120                 125             
Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Phe Gly Leu
    130                 135                 140                 
Ser Phe Val Arg Phe His Ser Pro Pro Asp Lys Asp Glu Ala Glu Ala
145                 150                 155                 160 
Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg Val Lys
                165                 170                 175     
Glu Glu Asp Glu Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu Phe Phe
            180                 185                 190         
Ser Arg Ile Asn Lys Thr Ser Pro Val Thr Ala Ser Asp Pro Ala Gly
        195                 200                 205             
Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala Ser Ser
    210                 215                 220                 
Ala Ser Pro Val Ser Arg Ala Ile Gly Ser Thr Ser Lys Pro Gln Glu
225                 230                 235                 240 
Ser Pro Lys Gly Lys Arg Lys Leu Asp Leu Asn Gln Glu Glu Lys Lys
                245                 250                 255     
Thr Pro Ser Lys Pro Pro Ala Gln Leu Ser Pro Ser Val Pro Lys Arg
            260                 265                 270         
Pro Lys Leu Pro Ala Pro Thr Arg Thr Pro Ala Thr Ala Pro Val Pro
        275                 280                 285             
Ala Arg Ala Gln Gly Ala Val Thr Gly Lys Pro Arg Gly Glu Gly Thr
    290                 295                 300                 
Glu Pro Arg Arg Pro Arg Ala Gly Pro Glu Glu Leu Gly Lys Ile Leu
305                 310                 315                 320 
Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg Ser
                325                 330                 335     
Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro Asp
            340                 345                 350         
Trp Thr Arg Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr Pro
        355                 360                 365             
Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys Glu
    370                 375                 380                 
Trp Val Leu Asp Cys His Arg Met Arg Arg Arg Leu Pro Ser Gln Arg
385                 390                 395                 400 
Tyr Leu Met Ala Gly Pro Gly Ser Ser Ser Glu Glu Asp Glu Ala Ser
                405                 410                 415     
His Ser Gly Gly Ser Gly Asp Glu Ala Pro Lys Leu Pro Gln Lys Gln
            420                 425                 430         
Pro Gln Thr Lys Thr Lys Pro Thr Gln Ala Ala Gly Pro Ser Ser Pro
        435                 440                 445             
Gln Lys Pro Pro Thr Pro Glu Glu Thr Lys Ala Ala Ser Pro Val Leu
    450                 455                 460                 
Gln Glu Asp Ile Asp Ile Glu Gly Val Gln Ser Glu Gly Gln Asp Asn
465                 470                 475                 480 
Gly Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val Ala
                485                 490                 495     
Glu Gln Lys Glu His Arg Leu Pro Pro Gly Gln Glu Glu Asn Gly Glu
            500                 505                 510         
Asp Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Glu His
        515                 520                 525             
Gln Glu Pro Pro Asp Leu Pro Val Pro Glu Leu Pro Asp Phe Phe Gln
    530                 535                 540                 
Gly Lys His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg Arg
545                 550                 555                 560 
Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp Tyr
                565                 570                 575     
Met Ser Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp Pro
            580                 585                 590         
Ser Phe Glu Glu Ala Leu Met Asp Asn Pro Ser Leu Ala Phe Val Arg
        595                 600                 605             
Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro His
    610                 615                 620                 
Gln Leu Tyr Gly Val Val Pro Gln Ala
625                 630             


<210> 19
<211> 4001
<212> DNA
<213> Homo Sapien

<220> 
<223> PARP1

<400> 19
aggcatcagc aatctatcag ggaacggcgg tggccggtgc ggcgtgttcg gtggcggctc 60
tggccgctca ggcgcctgcg gctgggtgag cgcacgcgag gcggcgaggc ggcagcgtgt 120
ttctaggtcg tggcgtcggg cttccggagc tttggcggca gctaggggag gatggcggag 180
tcttcggata agctctatcg agtcgagtac gccaagagcg ggcgcgcctc ttgcaagaaa 240
tgcagcgaga gcatccccaa ggactcgctc cggatggcca tcatggtgca gtcgcccatg 300
tttgatggaa aagtcccaca ctggtaccac ttctcctgct tctggaaggt gggccactcc 360
atccggcacc ctgacgttga ggtggatggg ttctctgagc ttcggtggga tgaccagcag 420
aaagtcaaga agacagcgga agctggagga gtgacaggca aaggccagga tggaattggt 480
agcaaggcag agaagactct gggtgacttt gcagcagagt atgccaagtc caacagaagt 540
acgtgcaagg ggtgtatgga gaagatagaa aagggccagg tgcgcctgtc caagaagatg 600
gtggacccgg agaagccaca gctaggcatg attgaccgct ggtaccatcc aggctgcttt 660
gtcaagaaca gggaggagct gggtttccgg cccgagtaca gtgcgagtca gctcaagggc 720
ttcagcctcc ttgctacaga ggataaagaa gccctgaaga agcagctccc aggagtcaag 780
agtgaaggaa agagaaaagg cgatgaggtg gatggagtgg atgaagtggc gaagaagaaa 840
tctaaaaaag aaaaagacaa ggatagtaag cttgaaaaag ccctaaaggc tcagaacgac 900
ctgatctgga acatcaagga cgagctaaag aaagtgtgtt caactaatga cctgaaggag 960
ctactcatct tcaacaagca gcaagtgcct tctggggagt cggcgatctt ggaccgagta 1020
gctgatggca tggtgttcgg tgccctcctt ccctgcgagg aatgctcggg tcagctggtc 1080
ttcaagagcg atgcctatta ctgcactggg gacgtcactg cctggaccaa gtgtatggtc 1140
aagacacaga cacccaaccg gaaggagtgg gtaaccccaa aggaattccg agaaatctct 1200
tacctcaaga aattgaaggt taaaaaacag gaccgtatat tccccccaga aaccagcgcc 1260
tccgtggcgg ccacgcctcc gccctccaca gcctcggctc ctgctgctgt gaactcctct 1320
gcttcagcag ataagccatt atccaacatg aagatcctga ctctcgggaa gctgtcccgg 1380
aacaaggatg aagtgaaggc catgattgag aaactcgggg ggaagttgac ggggacggcc 1440
aacaaggctt ccctgtgcat cagcaccaaa aaggaggtgg aaaagatgaa taagaagatg 1500
gaggaagtaa aggaagccaa catccgagtt gtgtctgagg acttcctcca ggacgtctcc 1560
gcctccacca agagccttca ggagttgttc ttagcgcaca tcttgtcccc ttggggggca 1620
gaggtgaagg cagagcctgt tgaagttgtg gccccaagag ggaagtcagg ggctgcgctc 1680
tccaaaaaaa gcaagggcca ggtcaaggag gaaggtatca acaaatctga aaagagaatg 1740
aaattaactc ttaaaggagg agcagctgtg gatcctgatt ctggactgga acactctgcg 1800
catgtcctgg agaaaggtgg gaaggtcttc agtgccaccc ttggcctggt ggacatcgtt 1860
aaaggaacca actcctacta caagctgcag cttctggagg acgacaagga aaacaggtat 1920
tggatattca ggtcctgggg ccgtgtgggt acggtgatcg gtagcaacaa actggaacag 1980
atgccgtcca aggaggatgc cattgagcac ttcatgaaat tatatgaaga aaaaaccggg 2040
aacgcttggc actccaaaaa tttcacgaag tatcccaaaa agttctaccc cctggagatt 2100
gactatggcc aggatgaaga ggcagtgaag aagctgacag taaatcctgg caccaagtcc 2160
aagctcccca agccagttca ggacctcatc aagatgatct ttgatgtgga aagtatgaag 2220
aaagccatgg tggagtatga gatcgacctt cagaagatgc ccttggggaa gctgagcaaa 2280
aggcagatcc aggccgcata ctccatcctc agtgaggtcc agcaggcggt gtctcagggc 2340
agcagcgact ctcagatcct ggatctctca aatcgctttt acaccctgat cccccacgac 2400
tttgggatga agaagcctcc gctcctgaac aatgcagaca gtgtgcaggc caaggtggaa 2460
atgcttgaca acctgctgga catcgaggtg gcctacagtc tgctcagggg agggtctgat 2520
gatagcagca aggatcccat cgatgtcaac tatgagaagc tcaaaactga cattaaggtg 2580
gttgacagag attctgaaga agccgagatc atcaggaagt atgttaagaa cactcatgca 2640
accacacaca atgcgtatga cttggaagtc atcgatatct ttaagataga gcgtgaaggc 2700
gaatgccagc gttacaagcc ctttaagcag cttcataacc gaagattgct gtggcacggg 2760
tccaggacca ccaactttgc tgggatcctg tcccagggtc ttcggatagc cccgcctgaa 2820
gcgcccgtga caggctacat gtttggtaaa gggatctatt tcgctgacat ggtctccaag 2880
agtgccaact actgccatac gtctcaggga gacccaatag gcttaatcct gttgggagaa 2940
gttgcccttg gaaacatgta tgaactgaag cacgcttcac atatcagcaa gttacccaag 3000
ggcaagcaca gtgtcaaagg tttgggcaaa actacccctg atccttcagc taacattagt 3060
ctggatggtg tagacgttcc tcttgggacc gggatttcat ctggtgtgaa tgacacctct 3120
ctactatata acgagtacat tgtctatgat attgctcagg taaatctgaa gtatctgctg 3180
aaactgaaat tcaattttaa gacctccctg tggtaattgg gagaggtagc cgagtcacac 3240
ccggtggctc tggtatgaat tcacccgaag cgcttctgca ccaactcacc tggccgctaa 3300
gttgctgatg ggtagtacct gtactaaacc acctcagaaa ggattttaca gaaacgtgtt 3360
aaaggttttc tctaacttct caagtccctt gttttgtgtt gtgtctgtgg ggaggggttg 3420
ttttggggtt gtttttgttt tttcttgcca ggtagataaa actgacatag agaaaaggct 3480
ggagagagat tctgttgcat agactagtcc tatggaaaaa accaagcttc gttagaatgt 3540
ctgccttact ggtttcccca gggaaggaaa aatacacttc cacccttttt tctaagtgtt 3600
cgtctttagt tttgattttg gaaagatgtt aagcatttat ttttagttaa aaataaaaac 3660
taatttcata ctatttagat tttctttttt atcttgcact tattgtcccc tttttagttt 3720
tttttgtttg cctcttgtgg tgaggggtgt gggaagacca aaggaaggaa cgctaacaat 3780
ttctcatact tagaaacaaa aagagctttc cttctccagg aatactgaac atgggagctc 3840
ttgaaatatg tagtattaaa agttgcattt gaaattcttg actttcttat gggcactttt 3900
gtcttccaaa ttaaaactct accacaaata tacttaccca agggctaata gtaatactcg 3960
attaaaaatg cagatgcctt ctctaaaaaa aaaaaaaaaa a                     4001

<210> 20
<211> 1014
<212> PRT
<213> Homo Sapien

<220> 
<221> PEPTIDE        
<222> (1)...(1010)
<223> PARP1

<400> 20
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15      
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30          
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45              
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60                  
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80  
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95      
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110         
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125             
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140                 
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160 
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175     
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190         
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205             
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220                 
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240 
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255     
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270         
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285             
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300                 
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320 
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335     
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350         
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365             
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380                 
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400 
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415     
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430         
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445             
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460                 
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480 
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495     
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510         
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525             
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540                 
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560 
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575     
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590         
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605             
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620                 
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640 
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655     
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670         
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685             
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700                 
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720 
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735     
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750         
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765             
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780                 
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800 
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815     
Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830         
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845             
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860                 
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880 
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895     
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910         
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925             
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940                 
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960 
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975     
Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990         
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005            
Phe Lys Thr Ser Leu Trp
    1010                


<210> 21
<211> 601
<212> DNA
<213> Homo Sapien

<220> 
<223> XPD

<220> 
<221> misc_feature   
<222> 150, 444
<223> N = any nucleotide

<220> 
<221> misc_feature   
<222> 554
<223> R = g or a

<220> 
<221> misc_feature   
<222> 558
<223> M = a or c

<400> 21
ccagtgaact gcgctggccg cagcttcttg ggaacagtgc aggagggatg ggctggtggg 60
gtgagagggg gtctatcatc tcctggcccc cccttgcstc tgggtacctg gtggatagct 120
gccttctcct gcgattaaag gctgtggacn tgacagtgag aaatgtcacc tgacttcata 180
agaccttcta gcaccaccrc cgctgggaac cagggccagg caagactcag gagtcaccag 240
gaaccgttta tggccccacc cgccccactc agagctgctg agcaatctgc tctatcctct 300
acagcgtctc ctctgattct agctgctcca ggctgagcag ggacaggccc agctgatcct 360
cctgcagaga acagaggaaa gggagagggg ggcactgttg ggcaggggcc caggcagctg 420
ctgcacttcc ccaaccaccc cscngaatgg ccagtaggga caggatgttt gaatgaattt 480
ggagatgtcc gtataatcca gagcgggcca tccctgtcaa cataagatgg ggctgaggga 540
ggagccagct aggragtmgg agaaggaccg gctttctcca ggccagcacc gtctctcctg 600
a                                                                 601

<210> 22
<211> 601
<212> DNA
<213> Homo Sapien

<220> 
<223> PARP1

<400> 22
gacccatttg tctaaagtac cttcactgta ggtcccaaat gtcagcatgt acgagaggaa 60
agacagttct tccacctctc aactccccca ggccacaagg ccttgttaac attccagaaa 120
gtccttatga gctctcaata tgtgcagcag gtaacaggct ggccctgacc agcaggaggg 180
tttgccattc actgtgttgg accttctctg catgtaggtt ttctctgcca cctgggtgag 240
tctgtctcat tcaccatgat acctaagtcg ggggctttct tttgctcctc caggccaagg 300
yggaaatgct tgacaacctg ctggacatcg aggtggccta cagtctgctc aggggagggt 360
ctgatgatag cagcaaggat cccatcgatg tcaactatga gaagctcaaa actgacatta 420
aggtaacagg gtcaggcctt cctcaagcat cttaacctct catcctgaga gcagcggtcc 480
caaacttcca tgtgtgttag gatctcctgg aaagcttgtt aaaacacagg tggctggcgc 540
ccaataattc acttttctaa caagttcccg gacattgctg ctggtggtcc tttgagaacc 600
t                                                                 601
