                         SEQUENCE LISTING

<110>  SANOFI-AVENTIS
 
<120>  Protine de fusion Robo1-Fc et son utilisation dans le traitement
        des tumeurs.

<130>  FR2009-116 PCT

<160>  24    

<170>  PatentIn version 3.3

<210>  1
<211>  660
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(660)

<400>  1
atg att gcg gag ccc gct cac ttt tac ctg ttt gga tta ata tgt ctc       48
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu         
1               5                   10                  15              

tgt tca ggc tcc cgt ctt cgt cag gaa gat ttt cca cct cgc att gtt       96
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val         
            20                  25                  30                  

gaa cac cct tca gac ctg att gtc tca aaa gga gaa cct gca act ttg      144
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu         
        35                  40                  45                      

aac tgc aaa gct gaa ggc cgc ccc aca ccc act att gaa tgg tac aaa      192
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys         
    50                  55                  60                          

ggg gga gag aga gtg gag aca gac aaa gat gac cct cgc tca cac cga      240
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg         
65                  70                  75                  80          

atg ttg ctg ccg agt gga tct tta ttt ttc tta cgt ata gta cat gga      288
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly         
                85                  90                  95              

cgg aaa agt aga cct gat gaa gga gtc tat gtc tgt gta gca agg aat      336
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn         
            100                 105                 110                 

tac ctt gga gag gct gtg agc cac aat gca tcg ctg gaa gta gcc ata      384
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile         
        115                 120                 125                     

ctt cgg gat gac ttc aga caa aac cct tcg gat gtc atg gtt gca gta      432
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val         
    130                 135                 140                         

gga gag cct gca gta atg gaa tgc caa cct cca cga ggc cat cct gag      480
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu         
145                 150                 155                 160         

ccc acc att tca tgg aag aaa gat ggc tct cca ctg gat gat aaa gat      528
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp         
                165                 170                 175             

gaa aga ata act ata cga gga gga aag ctc atg atc act tac acc cgt      576
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg         
            180                 185                 190                 

aaa agt gac gct ggc aaa tat gtt tgt gtt ggt acc aat atg gtt ggg      624
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly         
        195                 200                 205                     

gaa cgt gag agt gaa gta gcc gag ctg act gtc tta                      660
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu                         
    210                 215                 220                         


<210>  2
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
1               5                   10                  15      


Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
            20                  25                  30          


Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
        35                  40                  45              


Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
    50                  55                  60                  


Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
65                  70                  75                  80  


Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly 
                85                  90                  95      


Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn 
            100                 105                 110         


Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
        115                 120                 125             


Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
    130                 135                 140                 


Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
145                 150                 155                 160 


Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                165                 170                 175     


Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
            180                 185                 190         


Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
        195                 200                 205             


Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu 
    210                 215                 220 


<210>  3
<211>  1365
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1365)

<400>  3
atg att gcg gag ccc gct cac ttt tac ctg ttt gga tta ata tgt ctc       48
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu         
1               5                   10                  15              

tgt tca ggc tcc cgt ctt cgt cag gaa gat ttt cca cct cgc att gtt       96
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val         
            20                  25                  30                  

gaa cac cct tca gac ctg att gtc tca aaa gga gaa cct gca act ttg      144
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu         
        35                  40                  45                      

aac tgc aaa gct gaa ggc cgc ccc aca ccc act att gaa tgg tac aaa      192
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys         
    50                  55                  60                          

ggg gga gag aga gtg gag aca gac aaa gat gac cct cgc tca cac cga      240
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg         
65                  70                  75                  80          

atg ttg ctg ccg agt gga tct tta ttt ttc tta cgt ata gta cat gga      288
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly         
                85                  90                  95              

cgg aaa agt aga cct gat gaa gga gtc tat gtc tgt gta gca agg aat      336
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn         
            100                 105                 110                 

tac ctt gga gag gct gtg agc cac aat gca tcg ctg gaa gta gcc ata      384
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile         
        115                 120                 125                     

ctt cgg gat gac ttc aga caa aac cct tcg gat gtc atg gtt gca gta      432
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val         
    130                 135                 140                         

gga gag cct gca gta atg gaa tgc caa cct cca cga ggc cat cct gag      480
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu         
145                 150                 155                 160         

ccc acc att tca tgg aag aaa gat ggc tct cca ctg gat gat aaa gat      528
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp         
                165                 170                 175             

gaa aga ata act ata cga gga gga aag ctc atg atc act tac acc cgt      576
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg         
            180                 185                 190                 

aaa agt gac gct ggc aaa tat gtt tgt gtt ggt acc aat atg gtt ggg      624
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly         
        195                 200                 205                     

gaa cgt gag agt gaa gta gcc gag ctg act gtc tta gag aga cca tca      672
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser         
    210                 215                 220                         

ttt gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc cct gcc cct      720
Phe Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro         
225                 230                 235                 240         

gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct aag cct aag      768
Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys         
                245                 250                 255             

gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt gtg gtg gtg      816
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val         
            260                 265                 270                 

gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg tac gtg gac      864
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp         
        275                 280                 285                     

ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag gag cag ttc      912
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe         
    290                 295                 300                         

aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg cac cag gac      960
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp         
305                 310                 315                 320         

tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac aag ggc ctg     1008
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu         
                325                 330                 335             

ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc cag cct agg     1056
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg         
            340                 345                 350                 

gag cct cag gtg tac acc ctg cct cct agc cag gaa gag atg acc aag     1104
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys         
        355                 360                 365                     

aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac cct tcc gac     1152
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp         
    370                 375                 380                         

atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac aac tac aag     1200
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys         
385                 390                 395                 400         

acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc ctg tac tcc     1248
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser         
                405                 410                 415             

agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac gtc ttt tcc     1296
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser         
            420                 425                 430                 

tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag tcc     1344
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser         
        435                 440                 445                     

ctg tcc ctg tct ctg ggc tga                                         1365
Leu Ser Leu Ser Leu Gly                                                 
    450                                                                 


<210>  4
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
1               5                   10                  15      


Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
            20                  25                  30          


Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
        35                  40                  45              


Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
    50                  55                  60                  


Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
65                  70                  75                  80  


Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly 
                85                  90                  95      


Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn 
            100                 105                 110         


Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
        115                 120                 125             


Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
    130                 135                 140                 


Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
145                 150                 155                 160 


Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                165                 170                 175     


Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
            180                 185                 190         


Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
        195                 200                 205             


Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser 
    210                 215                 220                 


Phe Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly 
    450                 


<210>  5
<211>  1362
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1362)

<400>  5
atg att gcg gag ccc gct cac ttt tac ctg ttt gga tta ata tgt ctc       48
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu         
1               5                   10                  15              

tgt tca ggc tcc cgt ctt cgt cag gaa gat ttt cca cct cgc att gtt       96
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val         
            20                  25                  30                  

gaa cac cct tca gac ctg att gtc tca aaa gga gaa cct gca act ttg      144
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu         
        35                  40                  45                      

aac tgc aaa gct gaa ggc cgc ccc aca ccc act att gaa tgg tac aaa      192
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys         
    50                  55                  60                          

ggg gga gag aga gtg gag aca gac aaa gat gac cct cgc tca cac cga      240
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg         
65                  70                  75                  80          

atg ttg ctg ccg agt gga tct tta ttt ttc tta cgt ata gta cat gga      288
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly         
                85                  90                  95              

cgg aaa agt aga cct gat gaa gga gtc tat gtc tgt gta gca agg aat      336
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn         
            100                 105                 110                 

tac ctt gga gag gct gtg agc cac aat gca tcg ctg gaa gta gcc ata      384
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile         
        115                 120                 125                     

ctt cgg gat gac ttc aga caa aac cct tcg gat gtc atg gtt gca gta      432
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val         
    130                 135                 140                         

gga gag cct gca gta atg gaa tgc caa cct cca cga ggc cat cct gag      480
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu         
145                 150                 155                 160         

ccc acc att tca tgg aag aaa gat ggc tct cca ctg gat gat aaa gat      528
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp         
                165                 170                 175             

gaa aga ata act ata cga gga gga aag ctc atg atc act tac acc cgt      576
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg         
            180                 185                 190                 

aaa agt gac gct ggc aaa tat gtt tgt gtt ggt acc aat atg gtt ggg      624
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly         
        195                 200                 205                     

gaa cgt gag agt gaa gta gcc gag ctg act gtc tta gga ggc gga gga      672
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Gly Gly Gly Gly         
    210                 215                 220                         

tcc gag tcc aag tac ggc cct cct tgc cct ccc tgc cct gcc cct gag      720
Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu         
225                 230                 235                 240         

ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct aag cct aag gac      768
Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp         
                245                 250                 255             

acc ctg atg atc tcc cgg acc cct gag gtg acc tgt gtg gtg gtg gac      816
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp         
            260                 265                 270                 

gtg tcc cag gag gac cct gag gtc cag ttc aac tgg tac gtg gac ggc      864
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly         
        275                 280                 285                     

gtg gag gtg cac aac gcc aag acc aag cct cgg gag gag cag ttc aat      912
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn         
    290                 295                 300                         

tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg cac cag gac tgg      960
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp         
305                 310                 315                 320         

ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac aag ggc ctg ccc     1008
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro         
                325                 330                 335             

tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc cag cct agg gag     1056
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu         
            340                 345                 350                 

cct cag gtg tac acc ctg cct cct agc cag gaa gag atg acc aag aac     1104
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn         
        355                 360                 365                     

cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac cct tcc gac atc     1152
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile         
    370                 375                 380                         

gcc gtg gag tgg gag tcc aac ggc cag cct gag aac aac tac aag acc     1200
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr         
385                 390                 395                 400         

acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc ctg tac tcc agg     1248
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg         
                405                 410                 415             

ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac gtc ttt tcc tgc     1296
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys         
            420                 425                 430                 

tcc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag tcc ctg     1344
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu         
        435                 440                 445                     

tcc ctg tct ctg ggc tga                                             1362
Ser Leu Ser Leu Gly                                                     
    450                                                                 


<210>  6
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
1               5                   10                  15      


Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
            20                  25                  30          


Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
        35                  40                  45              


Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
    50                  55                  60                  


Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
65                  70                  75                  80  


Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly 
                85                  90                  95      


Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn 
            100                 105                 110         


Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
        115                 120                 125             


Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
    130                 135                 140                 


Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
145                 150                 155                 160 


Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                165                 170                 175     


Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
            180                 185                 190         


Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
        195                 200                 205             


Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Gly Gly Gly Gly 
    210                 215                 220                 


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Leu Gly 
    450             


<210>  7
<211>  1365
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1365)

<400>  7
atg att gcg gag ccc gct cac ttt tac ctg ttt gga tta ata tgt ctc       48
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu         
1               5                   10                  15              

tgt tca ggc tcc cgt ctt cgt cag gaa gat ttt cca cct cgc att gtt       96
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val         
            20                  25                  30                  

gaa cac cct tca gac cag att gtc tca aaa gga gaa cct gca act ttg      144
Glu His Pro Ser Asp Gln Ile Val Ser Lys Gly Glu Pro Ala Thr Leu         
        35                  40                  45                      

aac tgc aaa gct gaa ggc cgc ccc aca ccc act att gaa tgg tac aaa      192
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys         
    50                  55                  60                          

ggg gga gag aga gtg gag aca gac aaa gat gac cct cgc tca cac cga      240
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg         
65                  70                  75                  80          

atg ttg ctg ccg agt gga tct tta tat ttc tta cgt ata gta cat gga      288
Met Leu Leu Pro Ser Gly Ser Leu Tyr Phe Leu Arg Ile Val His Gly         
                85                  90                  95              

cgg aaa agt aga cct gat gaa gga gtc tat gtc tgt gta gca agg aat      336
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn         
            100                 105                 110                 

tac ctt gga gag gct gtg agc cac aat gca tcg ctg gaa gta gcc ata      384
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile         
        115                 120                 125                     

ctt cgg gat gac ttc aga caa aac cct tcg gat gtc atg gtt gca gta      432
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val         
    130                 135                 140                         

gga gag cct gca gta atg gaa tgc caa cct cca cga ggc cat cct gag      480
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu         
145                 150                 155                 160         

ccc acc att tca tgg aag aaa gat ggc tct cca ctg gat gat aaa gat      528
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp         
                165                 170                 175             

gaa aga ata act ata cga gga gga aag ctc atg atc act tac acc cgt      576
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg         
            180                 185                 190                 

aaa agt gac gct ggc aaa tat gtt tgt gtt ggt acc aat atg gtt ggg      624
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly         
        195                 200                 205                     

gaa cgt gag agt gaa gta gcc gag ctg act gtc tta gag aga cca tca      672
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser         
    210                 215                 220                         

ttt gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc cct gcc cct      720
Phe Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro         
225                 230                 235                 240         

gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct aag cct aag      768
Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys         
                245                 250                 255             

gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt gtg gtg gtg      816
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val         
            260                 265                 270                 

gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg tac gtg gac      864
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp         
        275                 280                 285                     

ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag gag cag ttc      912
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe         
    290                 295                 300                         

aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg cac cag gac      960
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp         
305                 310                 315                 320         

tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac aag ggc ctg     1008
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu         
                325                 330                 335             

ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc cag cct agg     1056
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg         
            340                 345                 350                 

gag cct cag gtg tac acc ctg cct cct agc cag gaa gag atg acc aag     1104
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys         
        355                 360                 365                     

aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac cct tcc gac     1152
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp         
    370                 375                 380                         

atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac aac tac aag     1200
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys         
385                 390                 395                 400         

acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc ctg tac tcc     1248
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser         
                405                 410                 415             

agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac gtc ttt tcc     1296
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser         
            420                 425                 430                 

tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag tcc     1344
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser         
        435                 440                 445                     

ctg tcc ctg tct ctg ggc tga                                         1365
Leu Ser Leu Ser Leu Gly                                                 
    450                                                                 


<210>  8
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
1               5                   10                  15      


Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
            20                  25                  30          


Glu His Pro Ser Asp Gln Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
        35                  40                  45              


Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
    50                  55                  60                  


Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
65                  70                  75                  80  


Met Leu Leu Pro Ser Gly Ser Leu Tyr Phe Leu Arg Ile Val His Gly 
                85                  90                  95      


Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn 
            100                 105                 110         


Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
        115                 120                 125             


Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
    130                 135                 140                 


Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
145                 150                 155                 160 


Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                165                 170                 175     


Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
            180                 185                 190         


Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
        195                 200                 205             


Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser 
    210                 215                 220                 


Phe Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly 
    450                 


<210>  9
<211>  1365
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1365)

<400>  9
atg att gcg gag ccc gct cac ttt tac ctg ttt gga tta ata tgt ctc       48
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu         
1               5                   10                  15              

tgt tca ggc tcc cgt ctt cgt cag gaa gat ttt cca cct cgc att gtt       96
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val         
            20                  25                  30                  

gaa cac cct tca gac ctg att gtc tca aaa gga gaa cct gca act ttg      144
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu         
        35                  40                  45                      

aac tgc aaa gct gaa ggc cgc ccc aca ccc act att gaa tgg tac aaa      192
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys         
    50                  55                  60                          

ggg gga gag aga gtg gag aca gac aaa gat gac cct cgc tca cac cga      240
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg         
65                  70                  75                  80          

atg ttg ctg ccg agt gga tct tta ttt ttc tta cgt ata gta cat gga      288
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly         
                85                  90                  95              

gcc gcc agt aga cct gat gaa gga gtc tat gtc tgt gta gca agg aat      336
Ala Ala Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn         
            100                 105                 110                 

tac ctt gga gag gct gtg agc cac aat gca tcg ctg gaa gta gcc ata      384
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile         
        115                 120                 125                     

ctt cgg gat gac ttc aga caa aac cct tcg gat gtc atg gtt gca gta      432
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val         
    130                 135                 140                         

gga gag cct gca gta atg gaa tgc caa cct cca cga ggc cat cct gag      480
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu         
145                 150                 155                 160         

ccc acc att tca tgg aag aaa gat ggc tct cca ctg gat gat aaa gat      528
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp         
                165                 170                 175             

gaa aga ata act ata cga gga gga aag ctc atg atc act tac acc cgt      576
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg         
            180                 185                 190                 

aaa agt gac gct ggc aaa tat gtt tgt gtt ggt acc aat atg gtt ggg      624
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly         
        195                 200                 205                     

gaa cgt gag agt gaa gta gcc gag ctg act gtc tta gag aga cca tca      672
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser         
    210                 215                 220                         

ttt gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc cct gcc cct      720
Phe Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro         
225                 230                 235                 240         

gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct aag cct aag      768
Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys         
                245                 250                 255             

gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt gtg gtg gtg      816
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val         
            260                 265                 270                 

gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg tac gtg gac      864
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp         
        275                 280                 285                     

ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag gag cag ttc      912
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe         
    290                 295                 300                         

aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg cac cag gac      960
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp         
305                 310                 315                 320         

tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac aag ggc ctg     1008
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu         
                325                 330                 335             

ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc cag cct agg     1056
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg         
            340                 345                 350                 

gag cct cag gtg tac acc ctg cct cct agc cag gaa gag atg acc aag     1104
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys         
        355                 360                 365                     

aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac cct tcc gac     1152
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp         
    370                 375                 380                         

atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac aac tac aag     1200
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys         
385                 390                 395                 400         

acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc ctg tac tcc     1248
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser         
                405                 410                 415             

agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac gtc ttt tcc     1296
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser         
            420                 425                 430                 

tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag tcc     1344
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser         
        435                 440                 445                     

ctg tcc ctg tct ctg ggc tga                                         1365
Leu Ser Leu Ser Leu Gly                                                 
    450                                                                 


<210>  10
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
1               5                   10                  15      


Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
            20                  25                  30          


Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
        35                  40                  45              


Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
    50                  55                  60                  


Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
65                  70                  75                  80  


Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly 
                85                  90                  95      


Ala Ala Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn 
            100                 105                 110         


Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
        115                 120                 125             


Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
    130                 135                 140                 


Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
145                 150                 155                 160 


Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                165                 170                 175     


Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
            180                 185                 190         


Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
        195                 200                 205             


Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser 
    210                 215                 220                 


Phe Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly 
    450                 


<210>  11
<211>  717
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(717)

<400>  11
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt       48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu         
1               5                   10                  15              

gtc acg aat tca ttg cac tgc cct gcc gcc tgt acc tgt agc aac aat       96
Val Thr Asn Ser Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn         
            20                  25                  30                  

atc gta gac tgt cgt ggg aaa ggt ctc act gag atc ccc aca aat ctt      144
Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu         
        35                  40                  45                      

cca gag acc atc aca gaa ata cgt ttg gaa cag aac aca atc aaa gtc      192
Pro Glu Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Thr Ile Lys Val         
    50                  55                  60                          

atc cct cct gga gct ttc tca cca tat aaa aag ctt aga cga att gac      240
Ile Pro Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp         
65                  70                  75                  80          

ctg agc aat aat cag atc tct gaa ctt gca cca gat gct ttc caa gga      288
Leu Ser Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly         
                85                  90                  95              

cta cgc tct ctg aat tca ctt gtc ctc tat gga aat aaa atc aca gaa      336
Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu         
            100                 105                 110                 

ctc ccc aaa agt tta ttt gaa gga ctg ttt tcc tta cag ctc cta tta      384
Leu Pro Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu         
        115                 120                 125                     

ttg aat gcc aac aag ata aac tgc ctt cgg gta gat gct ttt cag gat      432
Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp         
    130                 135                 140                         

ctc cac aac ttg aac ctt ctc tcc cta tat gac aac aag ctt cag acc      480
Leu His Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr         
145                 150                 155                 160         

atc gcc aag ggg acc ttt tca cct ctt cgg gcc att caa act atg cat      528
Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met His         
                165                 170                 175             

ttg gcc cag aac ccc ttt att tgt gac tgc cat ctc aag tgg cta gcg      576
Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala         
            180                 185                 190                 

gat tat ctc cat acc aac ccg att gag acc agt ggt gcc cgt tgc acc      624
Asp Tyr Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr         
        195                 200                 205                     

agc ccc cgc cgc ctg gca aac aaa aga att gga cag atc aaa agc aag      672
Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys         
    210                 215                 220                         

aaa ttc cgt tgt tca ggt agc gct cat cac cat cat cat cac tga          717
Lys Phe Arg Cys Ser Gly Ser Ala His His His His His His                 
225                 230                 235                             


<210>  12
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn 
            20                  25                  30          


Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu 
        35                  40                  45              


Pro Glu Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Thr Ile Lys Val 
    50                  55                  60                  


Ile Pro Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp 
65                  70                  75                  80  


Leu Ser Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly 
                85                  90                  95      


Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu 
            100                 105                 110         


Leu Pro Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu 
        115                 120                 125             


Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp 
    130                 135                 140                 


Leu His Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr 
145                 150                 155                 160 


Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met His 
                165                 170                 175     


Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala 
            180                 185                 190         


Asp Tyr Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr 
        195                 200                 205             


Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys 
    210                 215                 220                 


Lys Phe Arg Cys Ser Gly Ser Ala His His His His His His 
225                 230                 235             


<210>  13
<211>  1467
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1467)

<400>  13
atg cgc ggc gtt ggc tgg cag atg ctg tcc ctg tcg ctg ggg tta gtg       48
Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val         
1               5                   10                  15              

ctg gcg atc ctg aac aag gtg gca ccg cag gcg tgc ccg gcg cag tgc       96
Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys         
            20                  25                  30                  

tct tgc tcg ggc agc aca gtg gac tgt cac ggg ctg gcg ctg cgc agc      144
Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser         
        35                  40                  45                      

gtg ccc agg aat atc ccc cgc aac acc gag aga ctg gat tta aat gga      192
Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly         
    50                  55                  60                          

aat aac atc aca aga att acg aag aca gat ttt gct ggt ctt aga cat      240
Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His         
65                  70                  75                  80          

cta aga gtt ctt cag ctt atg gag aat aag att agc acc att gaa aga      288
Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg         
                85                  90                  95              

gga gca ttc cag gat ctt aaa gaa cta gag aga ctg cgt tta aac aga      336
Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg         
            100                 105                 110                 

aat cac ctt cag ctg ttt cct gag ttg ctg ttt ctt ggg act gcg aag      384
Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys         
        115                 120                 125                     

cta tac agg ctt gat ctc agt gaa aac caa att cag gca atc cca agg      432
Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg         
    130                 135                 140                         

aaa gct ttc cgt ggg gca gtt gac ata aaa aat ttg caa ctg gat tac      480
Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr         
145                 150                 155                 160         

aac cag atc agc tgt att gaa gat ggg gca ttc agg gct ctc cgg gac      528
Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp         
                165                 170                 175             

ctg gaa gtg ctc act ctc aac aat aac aac att act aga ctt tct gtg      576
Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val         
            180                 185                 190                 

gca agt ttc aac cat atg cct aaa ctt agg act ttt cga ctg cat tca      624
Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser         
        195                 200                 205                     

aac aac ctg tat tgt gac tgc cac ctg gcc tgg ctc tcc gac tgg ctt      672
Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu         
    210                 215                 220                         

cgc caa agg cct cgg gtt ggt ctg tac act cag tgt atg ggc ccc tcc      720
Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser         
225                 230                 235                 240         

cac ctg aga ggc cat aat gta gcc gag gtt caa aaa cga gaa ttt gtc      768
His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val         
                245                 250                 255             

tgc agt ggt cac cag tca ttt atg gct cct tct tgt agt gtt ttg cac      816
Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His         
            260                 265                 270                 

tgc cct gcc gcc tgt acc tgt agc aac aat atc gta gac tgt cgt ggg      864
Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly         
        275                 280                 285                     

aaa ggt ctc act gag atc ccc aca aat ctt cca gag acc atc aca gaa      912
Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu         
    290                 295                 300                         

ata cgt ttg gaa cag aac aca atc aaa gtc atc cct cct gga gct ttc      960
Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe         
305                 310                 315                 320         

tca cca tat aaa aag ctt aga cga att gac ctg agc aat aat cag atc     1008
Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile         
                325                 330                 335             

tct gaa ctt gca cca gat gct ttc caa gga cta cgc tct ctg aat tca     1056
Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser         
            340                 345                 350                 

ctt gtc ctc tat gga aat aaa atc aca gaa ctc ccc aaa agt tta ttt     1104
Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe         
        355                 360                 365                     

gaa gga ctg ttt tcc tta cag ctc cta tta ttg aat gcc aac aag ata     1152
Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile         
    370                 375                 380                         

aac tgc ctt cgg gta gat gct ttt cag gat ctc cac aac ttg aac ctt     1200
Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu         
385                 390                 395                 400         

ctc tcc cta tat gac aac aag ctt cag acc atc gcc aag ggg acc ttt     1248
Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe         
                405                 410                 415             

tca cct ctt cgg gcc att caa act atg cat ttg gcc cag aac ccc ttt     1296
Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe         
            420                 425                 430                 

att tgt gac tgc cat ctc aag tgg cta gcg gat tat ctc cat acc aac     1344
Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn         
        435                 440                 445                     

ccg att gag acc agt ggt gcc cgt tgc acc agc ccc cgc cgc ctg gca     1392
Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala         
    450                 455                 460                         

aac aaa aga att gga cag atc aaa agc aag aaa ttc cgt tgt tca ggt     1440
Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Gly         
465                 470                 475                 480         

agc gct cat cac cat cat cat cac tga                                 1467
Ser Ala His His His His His His                                         
                485                                                     


<210>  14
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val 
1               5                   10                  15      


Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys 
            20                  25                  30          


Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser 
        35                  40                  45              


Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly 
    50                  55                  60                  


Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His 
65                  70                  75                  80  


Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg 
                85                  90                  95      


Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg 
            100                 105                 110         


Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys 
        115                 120                 125             


Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg 
    130                 135                 140                 


Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr 
145                 150                 155                 160 


Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp 
                165                 170                 175     


Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val 
            180                 185                 190         


Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser 
        195                 200                 205             


Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu 
    210                 215                 220                 


Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser 
225                 230                 235                 240 


His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val 
                245                 250                 255     


Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His 
            260                 265                 270         


Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
        275                 280                 285             


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
    290                 295                 300                 


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
305                 310                 315                 320 


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
                325                 330                 335     


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
            340                 345                 350         


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
        355                 360                 365             


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
    370                 375                 380                 


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
385                 390                 395                 400 


Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
                405                 410                 415     


Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
            420                 425                 430         


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
        435                 440                 445             


Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala 
    450                 455                 460                 


Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Gly 
465                 470                 475                 480 


Ser Ala His His His His His His 
                485             


<210>  15
<211>  3390
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3390)

<400>  15
atg cgc ggc gtt ggc tgg cag atg ctg tcc ctg tcg ctg ggg tta gtg       48
Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val         
1               5                   10                  15              

ctg gcg atc ctg aac aag gtg gca ccg cag gcg tgc ccg gcg cag tgc       96
Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys         
            20                  25                  30                  

tct tgc tcg ggc agc aca gtg gac tgt cac ggg ctg gcg ctg cgc agc      144
Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser         
        35                  40                  45                      

gtg ccc agg aat atc ccc cgc aac acc gag aga ctg gat tta aat gga      192
Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly         
    50                  55                  60                          

aat aac atc aca aga att acg aag aca gat ttt gct ggt ctt aga cat      240
Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His         
65                  70                  75                  80          

cta aga gtt ctt cag ctt atg gag aat aag att agc acc att gaa aga      288
Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg         
                85                  90                  95              

gga gca ttc cag gat ctt aaa gaa cta gag aga ctg cgt tta aac aga      336
Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg         
            100                 105                 110                 

aat cac ctt cag ctg ttt cct gag ttg ctg ttt ctt ggg act gcg aag      384
Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys         
        115                 120                 125                     

cta tac agg ctt gat ctc agt gaa aac caa att cag gca atc cca agg      432
Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg         
    130                 135                 140                         

aaa gct ttc cgt ggg gca gtt gac ata aaa aat ttg caa ctg gat tac      480
Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr         
145                 150                 155                 160         

aac cag atc agc tgt att gaa gat ggg gca ttc agg gct ctc cgg gac      528
Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp         
                165                 170                 175             

ctg gaa gtg ctc act ctc aac aat aac aac att act aga ctt tct gtg      576
Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val         
            180                 185                 190                 

gca agt ttc aac cat atg cct aaa ctt agg act ttt cga ctg cat tca      624
Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser         
        195                 200                 205                     

aac aac ctg tat tgt gac tgc cac ctg gcc tgg ctc tcc gac tgg ctt      672
Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu         
    210                 215                 220                         

cgc caa agg cct cgg gtt ggt ctg tac act cag tgt atg ggc ccc tcc      720
Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser         
225                 230                 235                 240         

cac ctg aga ggc cat aat gta gcc gag gtt caa aaa cga gaa ttt gtc      768
His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val         
                245                 250                 255             

tgc agt ggt cac cag tca ttt atg gct cct tct tgt agt gtt ttg cac      816
Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His         
            260                 265                 270                 

tgc cct gcc gcc tgt acc tgt agc aac aat atc gta gac tgt cgt ggg      864
Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly         
        275                 280                 285                     

aaa ggt ctc act gag atc ccc aca aat ctt cca gag acc atc aca gaa      912
Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu         
    290                 295                 300                         

ata cgt ttg gaa cag aac aca atc aaa gtc atc cct cct gga gct ttc      960
Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe         
305                 310                 315                 320         

tca cca tat aaa aag ctt aga cga att gac ctg agc aat aat cag atc     1008
Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile         
                325                 330                 335             

tct gaa ctt gca cca gat gct ttc caa gga cta cgc tct ctg aat tca     1056
Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser         
            340                 345                 350                 

ctt gtc ctc tat gga aat aaa atc aca gaa ctc ccc aaa agt tta ttt     1104
Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe         
        355                 360                 365                     

gaa gga ctg ttt tcc tta cag ctc cta tta ttg aat gcc aac aag ata     1152
Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile         
    370                 375                 380                         

aac tgc ctt cgg gta gat gct ttt cag gat ctc cac aac ttg aac ctt     1200
Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu         
385                 390                 395                 400         

ctc tcc cta tat gac aac aag ctt cag acc atc gcc aag ggg acc ttt     1248
Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe         
                405                 410                 415             

tca cct ctt cgg gcc att caa act atg cat ttg gcc cag aac ccc ttt     1296
Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe         
            420                 425                 430                 

att tgt gac tgc cat ctc aag tgg cta gcg gat tat ctc cat acc aac     1344
Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn         
        435                 440                 445                     

ccg att gag acc agt ggt gcc cgt tgc acc agc ccc cgc cgc ctg gca     1392
Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala         
    450                 455                 460                         

aac aaa aga att gga cag atc aaa agc aag aaa ttc cgt tgt tca gct     1440
Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala         
465                 470                 475                 480         

aaa gaa cag tat ttc att cca ggt aca gaa gat tat cga tca aaa tta     1488
Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Arg Ser Lys Leu         
                485                 490                 495             

agt gga gac tgc ttt gcg gat ctg gct tgc cct gaa aag tgt cgc tgt     1536
Ser Gly Asp Cys Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys         
            500                 505                 510                 

gaa gga acc aca gta gat tgc tct aat caa aag ctc aac aaa atc ccg     1584
Glu Gly Thr Thr Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro         
        515                 520                 525                     

gag cac att ccc cag tac act gca gag ttg cgt ctc aat aat aat gaa     1632
Glu His Ile Pro Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu         
    530                 535                 540                         

ttt acc gtg ttg gaa gcc aca gga atc ttt aag aaa ctt cct caa tta     1680
Phe Thr Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu         
545                 550                 555                 560         

cgt aaa ata aac ttt agc aac aat aag atc aca gat att gag gag gga     1728
Arg Lys Ile Asn Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly         
                565                 570                 575             

gca ttt gaa gga gca tct ggt gta aat gaa ata ctt ctt acg agt aat     1776
Ala Phe Glu Gly Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn         
            580                 585                 590                 

cgt ttg gaa aat gtg cag cat aag atg ttc aag gga ttg gaa agc ctc     1824
Arg Leu Glu Asn Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu         
        595                 600                 605                     

aaa act ttg atg ttg aga agc aat cga ata acc tgt gtg ggg aat gac     1872
Lys Thr Leu Met Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp         
    610                 615                 620                         

agt ttc ata gga ctc agt tct gtg cgt ttg ctt tct ttg tat gat aat     1920
Ser Phe Ile Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn         
625                 630                 635                 640         

caa att act aca gtt gca cca ggg gca ttt gat act ctc cat tct tta     1968
Gln Ile Thr Thr Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu         
                645                 650                 655             

tct act cta aac ctc ttg gcc aat cct ttt aac tgt aac tgc tac ctg     2016
Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu         
            660                 665                 670                 

gct tgg ttg gga gag tgg ctg aga aag aag aga att gtc acg gga aat     2064
Ala Trp Leu Gly Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn         
        675                 680                 685                     

cct aga tgt caa aaa cca tac ttc ctg aaa gaa ata ccc atc cag gat     2112
Pro Arg Cys Gln Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp         
    690                 695                 700                         

gtg gcc att cag gac ttc act tgt gat gac gga aat gat gac aat agt     2160
Val Ala Ile Gln Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser         
705                 710                 715                 720         

tgc tcc cca ctt tct cgc tgt cct act gaa tgt act tgc ttg gat aca     2208
Cys Ser Pro Leu Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr         
                725                 730                 735             

gtc gtc cga tgt agc aac aag ggt ttg aag gtc ttg ccg aaa ggt att     2256
Val Val Arg Cys Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile         
            740                 745                 750                 

cca aga gat gtc aca gag ttg tat ctg gat gga aac caa ttt aca ctg     2304
Pro Arg Asp Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu         
        755                 760                 765                     

gtt ccc aag gaa ctc tcc aac tac aaa cat tta aca ctt ata gac tta     2352
Val Pro Lys Glu Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu         
    770                 775                 780                         

agt aac aac aga ata agc acg ctt tct aat cag agc ttc agc aac atg     2400
Ser Asn Asn Arg Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met         
785                 790                 795                 800         

acc cag ctc ctc acc tta att ctt agt tac aac cgt ctg aga tgt att     2448
Thr Gln Leu Leu Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile         
                805                 810                 815             

cct cct cgc acc ttt gat gga tta aag tct ctt cga tta ctt tct cta     2496
Pro Pro Arg Thr Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu         
            820                 825                 830                 

cat gga aat gac att tct gtt gtg cct gaa ggt gct ttc aat gat ctt     2544
His Gly Asn Asp Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu         
        835                 840                 845                     

tct gca tta tca cat cta gca att gga gcc aac cct ctt tac tgt gat     2592
Ser Ala Leu Ser His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp         
    850                 855                 860                         

tgt aac atg cag tgg tta tcc gac tgg gtg aag tcg gaa tat aag gag     2640
Cys Asn Met Gln Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu         
865                 870                 875                 880         

cct gga att gct cgt tgt gct ggt cct gga gaa atg gca gat aaa ctt     2688
Pro Gly Ile Ala Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu         
                885                 890                 895             

tta ctc aca act ccc tcc aaa aaa ttt acc tgt caa ggt cct gtg gat     2736
Leu Leu Thr Thr Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp         
            900                 905                 910                 

gtc aat att cta gct aag tgt aac ccc tgc cta tca aat ccg tgt aaa     2784
Val Asn Ile Leu Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys         
        915                 920                 925                     

aat gat ggc aca tgt aat agt gat cca gtt gac ttt tac cga tgc acc     2832
Asn Asp Gly Thr Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr         
    930                 935                 940                         

tgt cca tat ggt ttc aag ggg cag gac tgt gat gtc cca att cat gcc     2880
Cys Pro Tyr Gly Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala         
945                 950                 955                 960         

tgc atc agt aac cca tgt aaa cat gga gga act tgc cac tta aag gaa     2928
Cys Ile Ser Asn Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu         
                965                 970                 975             

gga gaa gaa gat gga ttc tgg tgt att tgt gct gat gga ttt gaa gga     2976
Gly Glu Glu Asp Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly         
            980                 985                 990                 

gaa aat tgt gaa gtc aac gtt gat  gat tgt gaa gat aat  gac tgt gaa   3024
Glu Asn Cys Glu Val Asn Val Asp  Asp Cys Glu Asp Asn  Asp Cys Glu       
        995                 1000                 1005                   

aat aat  tct aca tgt gtc gat  ggc att aat aac tac  aca tgc ctt      3069
Asn Asn  Ser Thr Cys Val Asp  Gly Ile Asn Asn Tyr  Thr Cys Leu          
    1010                 1015                 1020                      

tgc cca  cct gag tat aca ggt  gag ttg tgt gag gag  aag ctg gac      3114
Cys Pro  Pro Glu Tyr Thr Gly  Glu Leu Cys Glu Glu  Lys Leu Asp          
    1025                 1030                 1035                      

ttc tgt  gcc cag gac ctg aac  ccc tgc cag cac gat  tca aag tgc      3159
Phe Cys  Ala Gln Asp Leu Asn  Pro Cys Gln His Asp  Ser Lys Cys          
    1040                 1045                 1050                      

atc cta  act cca aag gga ttc  aaa tgt gac tgc aca  cca ggg tac      3204
Ile Leu  Thr Pro Lys Gly Phe  Lys Cys Asp Cys Thr  Pro Gly Tyr          
    1055                 1060                 1065                      

gta ggt  gaa cac tgc gac atc  gat ttt gac gac tgc  caa gac aac      3249
Val Gly  Glu His Cys Asp Ile  Asp Phe Asp Asp Cys  Gln Asp Asn          
    1070                 1075                 1080                      

aag tgt  aaa aac gga gcc cac  tgc aca gat gca gtg  aac ggc tat      3294
Lys Cys  Lys Asn Gly Ala His  Cys Thr Asp Ala Val  Asn Gly Tyr          
    1085                 1090                 1095                      

acg tgc  ata tgc ccc gaa ggt  tac agt ggc ttg ttc  tgt gag ttt      3339
Thr Cys  Ile Cys Pro Glu Gly  Tyr Ser Gly Leu Phe  Cys Glu Phe          
    1100                 1105                 1110                      

tct cca  ccc atg gtc ctc cct  cgt agc gct cat cac  cat cat cat      3384
Ser Pro  Pro Met Val Leu Pro  Arg Ser Ala His His  His His His          
    1115                 1120                 1125                      

cac tga                                                             3390
His                                                                     
                                                                        


<210>  16
<211>  1129
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val 
1               5                   10                  15      


Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys 
            20                  25                  30          


Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser 
        35                  40                  45              


Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly 
    50                  55                  60                  


Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His 
65                  70                  75                  80  


Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg 
                85                  90                  95      


Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg 
            100                 105                 110         


Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys 
        115                 120                 125             


Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg 
    130                 135                 140                 


Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr 
145                 150                 155                 160 


Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp 
                165                 170                 175     


Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val 
            180                 185                 190         


Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser 
        195                 200                 205             


Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu 
    210                 215                 220                 


Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser 
225                 230                 235                 240 


His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val 
                245                 250                 255     


Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His 
            260                 265                 270         


Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
        275                 280                 285             


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
    290                 295                 300                 


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
305                 310                 315                 320 


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
                325                 330                 335     


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
            340                 345                 350         


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
        355                 360                 365             


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
    370                 375                 380                 


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
385                 390                 395                 400 


Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
                405                 410                 415     


Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
            420                 425                 430         


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
        435                 440                 445             


Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala 
    450                 455                 460                 


Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala 
465                 470                 475                 480 


Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Arg Ser Lys Leu 
                485                 490                 495     


Ser Gly Asp Cys Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys 
            500                 505                 510         


Glu Gly Thr Thr Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro 
        515                 520                 525             


Glu His Ile Pro Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu 
    530                 535                 540                 


Phe Thr Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu 
545                 550                 555                 560 


Arg Lys Ile Asn Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly 
                565                 570                 575     


Ala Phe Glu Gly Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn 
            580                 585                 590         


Arg Leu Glu Asn Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu 
        595                 600                 605             


Lys Thr Leu Met Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp 
    610                 615                 620                 


Ser Phe Ile Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn 
625                 630                 635                 640 


Gln Ile Thr Thr Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu 
                645                 650                 655     


Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu 
            660                 665                 670         


Ala Trp Leu Gly Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn 
        675                 680                 685             


Pro Arg Cys Gln Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp 
    690                 695                 700                 


Val Ala Ile Gln Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser 
705                 710                 715                 720 


Cys Ser Pro Leu Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr 
                725                 730                 735     


Val Val Arg Cys Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile 
            740                 745                 750         


Pro Arg Asp Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu 
        755                 760                 765             


Val Pro Lys Glu Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu 
    770                 775                 780                 


Ser Asn Asn Arg Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met 
785                 790                 795                 800 


Thr Gln Leu Leu Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile 
                805                 810                 815     


Pro Pro Arg Thr Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu 
            820                 825                 830         


His Gly Asn Asp Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu 
        835                 840                 845             


Ser Ala Leu Ser His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp 
    850                 855                 860                 


Cys Asn Met Gln Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu 
865                 870                 875                 880 


Pro Gly Ile Ala Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu 
                885                 890                 895     


Leu Leu Thr Thr Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp 
            900                 905                 910         


Val Asn Ile Leu Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys 
        915                 920                 925             


Asn Asp Gly Thr Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr 
    930                 935                 940                 


Cys Pro Tyr Gly Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala 
945                 950                 955                 960 


Cys Ile Ser Asn Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu 
                965                 970                 975     


Gly Glu Glu Asp Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly 
            980                 985                 990         


Glu Asn Cys Glu Val Asn Val Asp  Asp Cys Glu Asp Asn  Asp Cys Glu 
        995                 1000                 1005             


Asn Asn  Ser Thr Cys Val Asp  Gly Ile Asn Asn Tyr  Thr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Glu Tyr Thr Gly  Glu Leu Cys Glu Glu  Lys Leu Asp 
    1025                 1030                 1035             


Phe Cys  Ala Gln Asp Leu Asn  Pro Cys Gln His Asp  Ser Lys Cys 
    1040                 1045                 1050             


Ile Leu  Thr Pro Lys Gly Phe  Lys Cys Asp Cys Thr  Pro Gly Tyr 
    1055                 1060                 1065             


Val Gly  Glu His Cys Asp Ile  Asp Phe Asp Asp Cys  Gln Asp Asn 
    1070                 1075                 1080             


Lys Cys  Lys Asn Gly Ala His  Cys Thr Asp Ala Val  Asn Gly Tyr 
    1085                 1090                 1095             


Thr Cys  Ile Cys Pro Glu Gly  Tyr Ser Gly Leu Phe  Cys Glu Phe 
    1100                 1105                 1110             


Ser Pro  Pro Met Val Leu Pro  Arg Ser Ala His His  His His His 
    1115                 1120                 1125             


His 
    


<210>  17
<211>  717
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(717)

<400>  17
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt       48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu         
1               5                   10                  15              

gtc acg aat tca ttg cac tgc cct gcc gcc tgt acc tgt agc aac aat       96
Val Thr Asn Ser Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn         
            20                  25                  30                  

atc gta gac tgt cgt ggg aaa ggt ctc act gag atc ccc aca aat ctt      144
Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu         
        35                  40                  45                      

cca gag acc atc aca gaa ata cgt ttg gaa cag aac agc atc aga gtc      192
Pro Glu Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Ser Ile Arg Val         
    50                  55                  60                          

atc cct cct gga gct ttc tca cca tat aaa aag ctt aga cga ctg gac      240
Ile Pro Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Leu Asp         
65                  70                  75                  80          

ctg agc aat aat cag atc tct gaa ctt gca cca gat gct ttc caa gga      288
Leu Ser Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly         
                85                  90                  95              

cta cgc tct ctg aat tca ctt gtc ctc tat gga aat aaa atc aca gaa      336
Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu         
            100                 105                 110                 

ctc ccc aaa agt tta ttt gaa gga ctg ttt tcc tta cag ctc cta tta      384
Leu Pro Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu         
        115                 120                 125                     

ttg aat gcc aac aag ata aac tgc ctt cgg gta gat gct ttt cag gat      432
Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp         
    130                 135                 140                         

ctc cac aac ttg aac ctt ctc tcc cta tat gac aac aag ctt cag acc      480
Leu His Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr         
145                 150                 155                 160         

gtc gcc aag ggg acc ttt tca gct ctt cgg gcc att caa act atg cat      528
Val Ala Lys Gly Thr Phe Ser Ala Leu Arg Ala Ile Gln Thr Met His         
                165                 170                 175             

ttg gcc cag aac ccc ttt att tgt gac tgc cat ctc aag tgg cta gcg      576
Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala         
            180                 185                 190                 

gat tat ctc cat acc aac ccg att gag acc agt ggt gcc cgt tgc acc      624
Asp Tyr Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr         
        195                 200                 205                     

agc ccc cgc cgc ctg gca aac aaa aga att gga cag atc aaa agc aag      672
Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys         
    210                 215                 220                         

aaa ttc cgt tgt tca ggt agc gct cat cac cat cat cat cac tga          717
Lys Phe Arg Cys Ser Gly Ser Ala His His His His His His                 
225                 230                 235                             


<210>  18
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  18

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn 
            20                  25                  30          


Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu 
        35                  40                  45              


Pro Glu Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Ser Ile Arg Val 
    50                  55                  60                  


Ile Pro Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Leu Asp 
65                  70                  75                  80  


Leu Ser Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly 
                85                  90                  95      


Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu 
            100                 105                 110         


Leu Pro Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu 
        115                 120                 125             


Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp 
    130                 135                 140                 


Leu His Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr 
145                 150                 155                 160 


Val Ala Lys Gly Thr Phe Ser Ala Leu Arg Ala Ile Gln Thr Met His 
                165                 170                 175     


Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala 
            180                 185                 190         


Asp Tyr Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr 
        195                 200                 205             


Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys 
    210                 215                 220                 


Lys Phe Arg Cys Ser Gly Ser Ala His His His His His His 
225                 230                 235             


<210>  19
<211>  726
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(726)

<400>  19
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt       48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu         
1               5                   10                  15              

gtc acg aat tca ctg tcc tcc ggc tcc tgc ccg gcc atg tgc acc tgc       96
Val Thr Asn Ser Leu Ser Ser Gly Ser Cys Pro Ala Met Cys Thr Cys         
            20                  25                  30                  

agc aat ggc atc gtg gac tgt cgt gga aaa ggc ctc act gcc atc ccg      144
Ser Asn Gly Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Ala Ile Pro         
        35                  40                  45                      

gcc aac ctg ccc gag acc atg acg gag ata cgc ctg gag ctg aac ggc      192
Ala Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu Glu Leu Asn Gly         
    50                  55                  60                          

atc aag tcc atc cct cct gga gcc ttc tca ccc tac aga aag cta cgg      240
Ile Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr Arg Lys Leu Arg         
65                  70                  75                  80          

agg ata gac ctg agc aac aat cag atc gct gag att gca ccc gac gcc      288
Arg Ile Asp Leu Ser Asn Asn Gln Ile Ala Glu Ile Ala Pro Asp Ala         
                85                  90                  95              

ttc cag ggc ctc cgc tcc ctg aac tcg ctg gtc ctc tat gga aac aag      336
Phe Gln Gly Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys         
            100                 105                 110                 

atc aca gac ctc ccc cgt ggt gtg ttt gga ggc cta tac acc cta cag      384
Ile Thr Asp Leu Pro Arg Gly Val Phe Gly Gly Leu Tyr Thr Leu Gln         
        115                 120                 125                     

ctc ctg ctc ctg aat gcc aac aag atc aac tgc atc cgg ccc gat gcc      432
Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Ile Arg Pro Asp Ala         
    130                 135                 140                         

ttc cag gac ctg cag aac ctc tca ctg ctc tcc ctg tat gac aac aag      480
Phe Gln Asp Leu Gln Asn Leu Ser Leu Leu Ser Leu Tyr Asp Asn Lys         
145                 150                 155                 160         

atc cag agc ctc gcc aag ggc act ttc acc tcc ctg cgg gcc atc cag      528
Ile Gln Ser Leu Ala Lys Gly Thr Phe Thr Ser Leu Arg Ala Ile Gln         
                165                 170                 175             

act ctg cac ctg gcc cag aac cct ttc att tgc gac tgt aac ctc aag      576
Thr Leu His Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys Asn Leu Lys         
            180                 185                 190                 

tgg ctg gca gac ttc ctg cgc acc aat ccc atc gag acg agt ggt gcc      624
Trp Leu Ala Asp Phe Leu Arg Thr Asn Pro Ile Glu Thr Ser Gly Ala         
        195                 200                 205                     

cgc tgt gcc agt ccc cgg cgc ctc gcc aac aag cgc atc ggg cag atc      672
Arg Cys Ala Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile         
    210                 215                 220                         

aag agc aag aag ttc cgg tgc tca ggt agc gct cat cac cat cat cat      720
Lys Ser Lys Lys Phe Arg Cys Ser Gly Ser Ala His His His His His         
225                 230                 235                 240         

cac tga                                                              726
His                                                                     
                                                                        


<210>  20
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Leu Ser Ser Gly Ser Cys Pro Ala Met Cys Thr Cys 
            20                  25                  30          


Ser Asn Gly Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Ala Ile Pro 
        35                  40                  45              


Ala Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu Glu Leu Asn Gly 
    50                  55                  60                  


Ile Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr Arg Lys Leu Arg 
65                  70                  75                  80  


Arg Ile Asp Leu Ser Asn Asn Gln Ile Ala Glu Ile Ala Pro Asp Ala 
                85                  90                  95      


Phe Gln Gly Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys 
            100                 105                 110         


Ile Thr Asp Leu Pro Arg Gly Val Phe Gly Gly Leu Tyr Thr Leu Gln 
        115                 120                 125             


Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Ile Arg Pro Asp Ala 
    130                 135                 140                 


Phe Gln Asp Leu Gln Asn Leu Ser Leu Leu Ser Leu Tyr Asp Asn Lys 
145                 150                 155                 160 


Ile Gln Ser Leu Ala Lys Gly Thr Phe Thr Ser Leu Arg Ala Ile Gln 
                165                 170                 175     


Thr Leu His Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys Asn Leu Lys 
            180                 185                 190         


Trp Leu Ala Asp Phe Leu Arg Thr Asn Pro Ile Glu Thr Ser Gly Ala 
        195                 200                 205             


Arg Cys Ala Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile 
    210                 215                 220                 


Lys Ser Lys Lys Phe Arg Cys Ser Gly Ser Ala His His His His His 
225                 230                 235                 240 


His 
    


<210>  21
<211>  726
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(726)

<400>  21
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt       48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu         
1               5                   10                  15              

gtc acg aat tca gcc aac tcc atc tcc tgc cct tcg ccc tgc acg tgc       96
Val Thr Asn Ser Ala Asn Ser Ile Ser Cys Pro Ser Pro Cys Thr Cys         
            20                  25                  30                  

agc aat aac atc gtg gac tgt cga gga aag ggc ttg atg gag att cct      144
Ser Asn Asn Ile Val Asp Cys Arg Gly Lys Gly Leu Met Glu Ile Pro         
        35                  40                  45                      

gcc aac ttg ccg gag ggc atc gtc gaa ata cgc cta gaa cag aac tcc      192
Ala Asn Leu Pro Glu Gly Ile Val Glu Ile Arg Leu Glu Gln Asn Ser         
    50                  55                  60                          

atc aaa gcc atc cct gca gga gcc ttc acc cag tac aag aaa ctg aag      240
Ile Lys Ala Ile Pro Ala Gly Ala Phe Thr Gln Tyr Lys Lys Leu Lys         
65                  70                  75                  80          

cga ata gac atc agc aag aat cag ata tcg gat att gct cca gat gcc      288
Arg Ile Asp Ile Ser Lys Asn Gln Ile Ser Asp Ile Ala Pro Asp Ala         
                85                  90                  95              

ttc cag ggc ctg aaa tca ctc aca tcg ctg gtc ctg tat ggg aac aag      336
Phe Gln Gly Leu Lys Ser Leu Thr Ser Leu Val Leu Tyr Gly Asn Lys         
            100                 105                 110                 

atc acc gag att gcc aag gga ctg ttt gat ggg ctg gtg tcc cta cag      384
Ile Thr Glu Ile Ala Lys Gly Leu Phe Asp Gly Leu Val Ser Leu Gln         
        115                 120                 125                     

ctg ctc ctc ctc aat gcc aac aag atc aac tgc ctg cgg gtg aac acg      432
Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asn Thr         
    130                 135                 140                         

ttt cag gac ctg cag aac ctc aac ttg ctc tcc ctg tat gac aac aag      480
Phe Gln Asp Leu Gln Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys         
145                 150                 155                 160         

ctg cag acc atc agc aag ggg ctc ttc gcc cct ctg cag tcc atc cag      528
Leu Gln Thr Ile Ser Lys Gly Leu Phe Ala Pro Leu Gln Ser Ile Gln         
                165                 170                 175             

aca ctc cac tta gcc caa aac cca ttt gtg tgc gac tgc cac ttg aag      576
Thr Leu His Leu Ala Gln Asn Pro Phe Val Cys Asp Cys His Leu Lys         
            180                 185                 190                 

tgg ctg gcc gac tac ctc cag gac aac ccc atc gag aca agc ggg gcc      624
Trp Leu Ala Asp Tyr Leu Gln Asp Asn Pro Ile Glu Thr Ser Gly Ala         
        195                 200                 205                     

cgc tgc agc agc ccg cgc cga ctc gcc aac aag cgc atc agc cag atc      672
Arg Cys Ser Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Ser Gln Ile         
    210                 215                 220                         

aag agc aag aag ttc cgg tgc tca ggt agc gct cat cac cat cat cat      720
Lys Ser Lys Lys Phe Arg Cys Ser Gly Ser Ala His His His His His         
225                 230                 235                 240         

cac tga                                                              726
His                                                                     
                                                                        


<210>  22
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Asn Ser Ile Ser Cys Pro Ser Pro Cys Thr Cys 
            20                  25                  30          


Ser Asn Asn Ile Val Asp Cys Arg Gly Lys Gly Leu Met Glu Ile Pro 
        35                  40                  45              


Ala Asn Leu Pro Glu Gly Ile Val Glu Ile Arg Leu Glu Gln Asn Ser 
    50                  55                  60                  


Ile Lys Ala Ile Pro Ala Gly Ala Phe Thr Gln Tyr Lys Lys Leu Lys 
65                  70                  75                  80  


Arg Ile Asp Ile Ser Lys Asn Gln Ile Ser Asp Ile Ala Pro Asp Ala 
                85                  90                  95      


Phe Gln Gly Leu Lys Ser Leu Thr Ser Leu Val Leu Tyr Gly Asn Lys 
            100                 105                 110         


Ile Thr Glu Ile Ala Lys Gly Leu Phe Asp Gly Leu Val Ser Leu Gln 
        115                 120                 125             


Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asn Thr 
    130                 135                 140                 


Phe Gln Asp Leu Gln Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys 
145                 150                 155                 160 


Leu Gln Thr Ile Ser Lys Gly Leu Phe Ala Pro Leu Gln Ser Ile Gln 
                165                 170                 175     


Thr Leu His Leu Ala Gln Asn Pro Phe Val Cys Asp Cys His Leu Lys 
            180                 185                 190         


Trp Leu Ala Asp Tyr Leu Gln Asp Asn Pro Ile Glu Thr Ser Gly Ala 
        195                 200                 205             


Arg Cys Ser Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Ser Gln Ile 
    210                 215                 220                 


Lys Ser Lys Lys Phe Arg Cys Ser Gly Ser Ala His His His His His 
225                 230                 235                 240 


His 
    


<210>  23
<211>  1362
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1362)

<400>  23
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt       48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu         
1               5                   10                  15              

gtc acg aat tca ctt cgt cag gaa gat ttt cca cct cgc att gtt gaa       96
Val Thr Asn Ser Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val Glu         
            20                  25                  30                  

cac cct tca gac ctg att gtc tca aaa gga gaa cct gca act ttg aac      144
His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu Asn         
        35                  40                  45                      

tgc aaa gct gaa ggc cgc ccc aca ccc act att gaa tgg tac aaa ggg      192
Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys Gly         
    50                  55                  60                          

gga gag aga gtg gag aca gac aaa gat gac cct cgc tca cac cga atg      240
Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg Met         
65                  70                  75                  80          

ttg ctg ccg agt gga tct tta ttt ttc tta cgt ata gta cat gga cgg      288
Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly Arg         
                85                  90                  95              

aaa agt aga cct gat gaa gga gtc tat gtc tgt gta gca agg aat tac      336
Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn Tyr         
            100                 105                 110                 

ctt gga gag gct gtg agc cac aat gca tcg ctg gaa gta gcc ata ctt      384
Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile Leu         
        115                 120                 125                     

cgg gat gac ttc aga caa aac cct tcg gat gtc atg gtt gca gta gga      432
Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val Gly         
    130                 135                 140                         

gag cct gca gta atg gaa tgc caa cct cca cga ggc cat cct gag ccc      480
Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu Pro         
145                 150                 155                 160         

acc att tca tgg aag aaa gat ggc tct cca ctg gat gat aaa gat gaa      528
Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp Glu         
                165                 170                 175             

aga ata act ata cga gga gga aag ctc atg atc act tac acc cgt aaa      576
Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg Lys         
            180                 185                 190                 

agt gac gct ggc aaa tat gtt tgt gtt ggt acc aat atg gtt ggg gaa      624
Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly Glu         
        195                 200                 205                     

cgt gag agt gaa gta gcc gag ctg act gtc tta gag aga cca tca ttt      672
Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser Phe         
    210                 215                 220                         

gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc cct gcc cct gag      720
Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu         
225                 230                 235                 240         

ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct aag cct aag gac      768
Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp         
                245                 250                 255             

acc ctg atg atc tcc cgg acc cct gag gtg acc tgt gtg gtg gtg gac      816
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp         
            260                 265                 270                 

gtg tcc cag gag gac cct gag gtc cag ttc aac tgg tac gtg gac ggc      864
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly         
        275                 280                 285                     

gtg gag gtg cac aac gcc aag acc aag cct cgg gag gag cag ttc aat      912
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn         
    290                 295                 300                         

tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg cac cag gac tgg      960
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp         
305                 310                 315                 320         

ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac aag ggc ctg ccc     1008
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro         
                325                 330                 335             

tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc cag cct agg gag     1056
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu         
            340                 345                 350                 

cct cag gtg tac acc ctg cct cct agc cag gaa gag atg acc aag aac     1104
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn         
        355                 360                 365                     

cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac cct tcc gac atc     1152
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile         
    370                 375                 380                         

gcc gtg gag tgg gag tcc aac ggc cag cct gag aac aac tac aag acc     1200
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr         
385                 390                 395                 400         

acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc ctg tac tcc agg     1248
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg         
                405                 410                 415             

ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac gtc ttt tcc tgc     1296
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys         
            420                 425                 430                 

tcc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag tcc ctg     1344
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu         
        435                 440                 445                     

tcc ctg tct ctg ggc tga                                             1362
Ser Leu Ser Leu Gly                                                     
    450                                                                 


<210>  24
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val Glu 
            20                  25                  30          


His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu Asn 
        35                  40                  45              


Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys Gly 
    50                  55                  60                  


Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg Met 
65                  70                  75                  80  


Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly Arg 
                85                  90                  95      


Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn Tyr 
            100                 105                 110         


Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile Leu 
        115                 120                 125             


Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val Gly 
    130                 135                 140                 


Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu Pro 
145                 150                 155                 160 


Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp Glu 
                165                 170                 175     


Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg Lys 
            180                 185                 190         


Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly Glu 
        195                 200                 205             


Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser Phe 
    210                 215                 220                 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Leu Gly 
    450             


