                               SEQUENCE LISTING	

<110> JN BIOSCIENCES, LLC
 
<120> ANTIBODIES TO CD122

<130> 057761-404154

<140>
<141>

<150> 61/360,405
<151> 2010-06-30

<150> 61/322,229
<151> 2010-04-08

<160> 77    

<170> PatentIn version 3.5

<210> 1
<211> 420
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (1)..(420)

<400> 1
atg aag ttg tgg tta aac tgg gtt ttt ctt tta aca ctt tta cat ggt         48
Met Lys Leu Trp Leu Asn Trp Val Phe Leu Leu Thr Leu Leu His Gly           
1               5                   10                  15                

atc cag tgt gag gtg aag ctg gtg gaa tct gga gga ggc ttg gta cag         96
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln           
            20                  25                  30                    

cct ggg ggt tct ctg aga ctc tcc tgt gca act tct ggg ttc acc ttc        144
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe           
        35                  40                  45                        

agt gat ttc tac atg gag tgg gtc cgc cag cct cca ggg aag aga ctg        192
Ser Asp Phe Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu           
    50                  55                  60                            

gag tgg att gct gca agt aga aac aaa gct aat gat tat aca aca gag        240
Glu Trp Ile Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu           
65                  70                  75                  80            

tac agt gca tct gtg aag ggt cgg ttc atc gtc tcc aga gac act tcc        288
Tyr Ser Ala Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser           
                85                  90                  95                

caa agc atc ctc tac ctt cag atg aat gcc ctg aga gct gag gac act        336
Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr           
            100                 105                 110                   

gcc att tat tac tgt gca aga tcc tac tat agg tac gac ggt atg gac        384
Ala Ile Tyr Tyr Cys Ala Arg Ser Tyr Tyr Arg Tyr Asp Gly Met Asp           
        115                 120                 125                       

tac tgg ggt caa gga acc tca gtc acc gtc tcc tca                        420
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser                           
    130                 135                 140                           


<210> 2
<211> 140
<212> PRT
<213> Mus sp.

<400> 2
Met Lys Leu Trp Leu Asn Trp Val Phe Leu Leu Thr Leu Leu His Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Phe Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu 
    50                  55                  60                  


Glu Trp Ile Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Ile Tyr Tyr Cys Ala Arg Ser Tyr Tyr Arg Tyr Asp Gly Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210> 3
<211> 384
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (1)..(384)

<400> 3
atg gat ttt caa gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata gtg tcc aga gga caa gtt gtt ctc acc cag tct cca gta atc         96
Val Ile Val Ser Arg Gly Gln Val Val Leu Thr Gln Ser Pro Val Ile           
            20                  25                  30                    

atg tct gca tct cca ggg gag aag gtc acc atg acc tgc agt gcc atc        144
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ile           
        35                  40                  45                        

tca agt gta agt tac atg tac tgg tac cag cag aag cca gga tcc tcc        192
Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser           
    50                  55                  60                            

ccc aga ctc ctg att tat gac aca tcc aac ctg gtt tct gga gtc cct        240
Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Val Ser Gly Val Pro           
65                  70                  75                  80            

gtt cgc ttc agt ggc agt ggg tct ggg acc tct tac tct ctc aca atc        288
Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile           
                85                  90                  95                

agc cga atg gag gct gaa gat gct gcc act tat tac tgc cag cag tgg        336
Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp           
            100                 105                 110                   

aat act tac ccg tac acg ttc gga ggg ggg acc aag ctg gaa ata aaa        384
Asn Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
        115                 120                 125                       


<210> 4
<211> 128
<212> PRT
<213> Mus sp.

<400> 4
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Val Ser Arg Gly Gln Val Val Leu Thr Gln Ser Pro Val Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ile 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Val Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210> 5
<211> 417
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (1)..(417)

<400> 5
atg aga gtg ttg att ctt gtg tac ctg ttg aca gtc ctt cct ggt ata         48
Met Arg Val Leu Ile Leu Val Tyr Leu Leu Thr Val Leu Pro Gly Ile           
1               5                   10                  15                

ctg tct gat gta cag ctt cag gag tca gga cct ggc ctg gtg aag cct         96
Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro           
            20                  25                  30                    

tct cag aca gtg tcc ctc acc tgc act gtc act ggc tac tct atc act        144
Ser Gln Thr Val Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr           
        35                  40                  45                        

aat gat aat cac tgg tgg aac tgg atc cgg cag gtt tca gga agc aaa        192
Asn Asp Asn His Trp Trp Asn Trp Ile Arg Gln Val Ser Gly Ser Lys           
    50                  55                  60                            

ctg gag tgg atg ggg tac ata gac tcc agt ggt agt tct gac aac aat        240
Leu Glu Trp Met Gly Tyr Ile Asp Ser Ser Gly Ser Ser Asp Asn Asn           
65                  70                  75                  80            

cca tct ctc aaa agt caa atc tcc atc act aga gac act tcc aag aac        288
Pro Ser Leu Lys Ser Gln Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn           
                85                  90                  95                

cag tta ttc ctg cag ttg aac tct gtg act att gaa gat ata ggc aca        336
Gln Leu Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Ile Gly Thr           
            100                 105                 110                   

tat tac tgt gca aga ggc ggt ggt agg gat tac tat ggc atg gac tac        384
Tyr Tyr Cys Ala Arg Gly Gly Gly Arg Asp Tyr Tyr Gly Met Asp Tyr           
        115                 120                 125                       

tgg ggt caa gga acc tca gtc acc gtc tcc tca                            417
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser                               
    130                 135                                               


<210> 6
<211> 139
<212> PRT
<213> Mus sp.

<400> 6
Met Arg Val Leu Ile Leu Val Tyr Leu Leu Thr Val Leu Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Thr Val Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Asn Asp Asn His Trp Trp Asn Trp Ile Arg Gln Val Ser Gly Ser Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Asp Ser Ser Gly Ser Ser Asp Asn Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Gln Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Leu Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Ile Gly Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Gly Arg Asp Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210> 7
<211> 393
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (1)..(393)

<400> 7
atg gag aca gac aca ctc ctg cta tgg gtg ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggt tcc act ggt gac att gtg ctg aca cag tct cct gct tcc tta gct         96
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala           
            20                  25                  30                    

gta tct ctg ggg cag agg gcc acc atc tca tgc agg gcc agc caa agt        144
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser           
        35                  40                  45                        

gtc agt aca tct agc tat agt tat gtt cac tgg tac caa cag aaa cca        192
Val Ser Thr Ser Ser Tyr Ser Tyr Val His Trp Tyr Gln Gln Lys Pro           
    50                  55                  60                            

gga cag cca ccc aaa ctc ctc atc aag tat gca tcc aac cta gaa tct        240
Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser           
65                  70                  75                  80            

ggg gtc cct gcc agg ttc agt ggc agt ggg tct ggg aca gac ttc acc        288
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr           
                85                  90                  95                

ctc aac atc cat cct gtg gag gag gag gat act gca aca tat tac tgt        336
Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys           
            100                 105                 110                   

cag cac agt tgg gac att ccg ttc acg ttc gga ggg ggg acc aag ctg        384
Gln His Ser Trp Asp Ile Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu           
        115                 120                 125                       

gaa ata aaa                                                            393
Glu Ile Lys                                                               
    130                                                                   


<210> 8
<211> 131
<212> PRT
<213> Mus sp.

<400> 8
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Thr Ser Ser Tyr Ser Tyr Val His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ser Trp Asp Ile Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210> 9
<211> 455
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (13)..(432)

<400> 9
actagtacca cc atg aag ttg tgg ttg aac tgg gtt ttt ctt ttg aca ctt       51
              Met Lys Leu Trp Leu Asn Trp Val Phe Leu Leu Thr Leu         
              1               5                   10                      

ttg cat gga atc cag tgt gaa gtg cag ctc gtg gaa tct gga gga ggc         99
Leu His Gly Ile Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly           
    15                  20                  25                            

ttg gtt cag cct ggg gga tct ctg aga ctc tcc tgt gca gcc tct ggg        147
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly           
30                  35                  40                  45            

ttc acc ttc agt gat ttc tac atg gag tgg gtc cgc cag gct cca ggg        195
Phe Thr Phe Ser Asp Phe Tyr Met Glu Trp Val Arg Gln Ala Pro Gly           
                50                  55                  60                

aag ggg ctc gag tgg att gct gca agt aga aac aaa gct aat gat tat        243
Lys Gly Leu Glu Trp Ile Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr           
            65                  70                  75                    

aca aca gag tac agt gca tct gtg aag ggt cgg ttc atc gtc tcc aga        291
Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Ile Val Ser Arg           
        80                  85                  90                        

gac gat tcc aag aac tca ctc tac ctt cag atg aat agc ctg aaa acc        339
Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr           
    95                  100                 105                           

gag gac act gcc gtg tat tac tgt gca aga tcc tac tat agg tac gac        387
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Arg Tyr Asp           
110                 115                 120                 125           

ggt atg gac tac tgg ggt caa gga acc aca gtc acc gtc tcc tca            432
Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser               
                130                 135                 140               

ggtaagttgg cttttttaag ctt                                              455


<210> 10
<211> 140
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Lys Leu Trp Leu Asn Trp Val Phe Leu Leu Thr Leu Leu His Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Phe Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Tyr Arg Tyr Asp Gly Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140 


<210> 11
<211> 418
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (13)..(396)

<400> 11
gctagcacca cc atg gat ttt caa gtg cag att ttc agc ttc ctg ctg atc       51
              Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile         
              1               5                   10                      

agt gcc tca gtc atc gtg tcc aga gga gaa att gtg ctc acc cag tct         99
Ser Ala Ser Val Ile Val Ser Arg Gly Glu Ile Val Leu Thr Gln Ser           
    15                  20                  25                            

cca gcc acc ctg tct ttg tct cca ggg gag aga gcc acc ctc tcc tgc        147
Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys           
30                  35                  40                  45            

agt gcc atc tca agt gtg agt tac atg tac tgg tac cag cag aag cca        195
Ser Ala Ile Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro           
                50                  55                  60                

gga cag gct ccc aga ctc ctg att tat gac aca tcc aac ctg gtg tct        243
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Val Ser           
            65                  70                  75                    

gga gtc cct gcc cgc ttc agt ggc agt gga tct ggg acc gac tac act        291
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr           
        80                  85                  90                        

ctc aca atc agc agc ctg gag cct gaa gat ttt gcc gtt tat tac tgc        339
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys           
    95                  100                 105                           

cag cag tgg aat act tac ccc tac acc ttc gga ggg ggg acc aaa gtg        387
Gln Gln Trp Asn Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val           
110                 115                 120                 125           

gaa atc aaa cgtaagtaga atccaagaat tc                                   418
Glu Ile Lys                                                               
                                                                          


<210> 12
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Val Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ile 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Val Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210> 13
<211> 452
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (13)..(429)

<400> 13
actagtacca cc atg aga gtg ttg att ctt gtg tac ctg ttg aca gtc ctt       51
              Met Arg Val Leu Ile Leu Val Tyr Leu Leu Thr Val Leu         
              1               5                   10                      

cct ggt att ctg tct cag gta cag ctt cag gag tca gga cct ggc ctg         99
Pro Gly Ile Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu           
    15                  20                  25                            

gtc aag cct tct cag aca ctg tcc ctc acc tgc act gtc tct ggc tac        147
Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr           
30                  35                  40                  45            

tct atc act aat gat aat cac tgg tgg aac tgg atc cgg cag cac cca        195
Ser Ile Thr Asn Asp Asn His Trp Trp Asn Trp Ile Arg Gln His Pro           
                50                  55                  60                

gga aag ggc ctg gaa tgg atg ggg tac atc gac tcc agt ggt tcc tct        243
Gly Lys Gly Leu Glu Trp Met Gly Tyr Ile Asp Ser Ser Gly Ser Ser           
            65                  70                  75                    

gac aac aat cca tct ctc aaa agt caa atc acc atc tca aga gac act        291
Asp Asn Asn Pro Ser Leu Lys Ser Gln Ile Thr Ile Ser Arg Asp Thr           
        80                  85                  90                        

tcc aag aac cag ctc tcc ctg aag ttg agc tct gtg act gcc gcc gat        339
Ser Lys Asn Gln Leu Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp           
    95                  100                 105                           

aca gcc gtg tat tac tgt gca aga ggc gga ggc agg gat tac tat ggc        387
Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gly Arg Asp Tyr Tyr Gly           
110                 115                 120                 125           

atg gac tac tgg ggt caa gga acc acc gtc acc gtc tcc tca                429
Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                   
                130                 135                                   

ggtaagaatg gcctctcaag ctt                                              452


<210> 14
<211> 139
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Arg Val Leu Ile Leu Val Tyr Leu Leu Thr Val Leu Pro Gly Ile 
1               5                   10                  15      


Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr 
        35                  40                  45              


Asn Asp Asn His Trp Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Asp Ser Ser Gly Ser Ser Asp Asn Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Gln Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Leu Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Gly Arg Asp Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 


<210> 15
<211> 428
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (13)..(405)

<400> 15
gctagcacca cc atg gag aca gac aca ctc ctg cta tgg gtg ctg ctg ctc       51
              Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu         
              1               5                   10                      

tgg gtt cca ggt tcc act ggt gac att gtg atg aca cag tct cct gac         99
Trp Val Pro Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp           
    15                  20                  25                            

tcc tta ggc gta tct ctg ggg gag agg gcc acc atc aac tgc agg gcc        147
Ser Leu Gly Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala           
30                  35                  40                  45            

agc caa agt gtc agc aca tct agc tat agt tat gtt cac tgg tac caa        195
Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Val His Trp Tyr Gln           
                50                  55                  60                

cag aaa cca gga cag cca ccc aaa ctc ctc atc aag tat gca tcc aac        243
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn           
            65                  70                  75                    

cta gaa tct ggg gtc cct gac agg ttc agc ggc tct ggg tct ggg aca        291
Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr           
        80                  85                  90                        

gac ttc acc ctc acc atc agc agc ctg cag gct gag gat gtg gca gtc        339
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val           
    95                  100                 105                           

tat tac tgt cag cac agt tgg gac att ccc ttc aca ttc gga cag ggg        387
Tyr Tyr Cys Gln His Ser Trp Asp Ile Pro Phe Thr Phe Gly Gln Gly           
110                 115                 120                 125           

acc aaa ctc gaa atc aaa cgtaagtagt cttctcagaa ttc                      428
Thr Lys Leu Glu Ile Lys                                                   
                130                                                       


<210> 16
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Gly 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Thr Ser Ser Tyr Ser Tyr Val His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            100                 105                 110         


Gln His Ser Trp Asp Ile Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
gccagtggat agacagatgg                                                   20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
gccagtggat agaccgatgg                                                   20


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
gccagtggat agactgatgg                                                   20


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
gatggataca gttggtgcag c                                                 21


<210> 21
<211> 19
<212> PRT
<213> Mus sp.

<400> 21
Met Lys Leu Trp Leu Asn Trp Val Phe Leu Leu Thr Leu Leu His Gly 
1               5                   10                  15      


Ile Gln Cys 
            


<210> 22
<211> 5
<212> PRT
<213> Mus sp.

<400> 22
Asp Phe Tyr Met Glu 
1               5   


<210> 23
<211> 19
<212> PRT
<213> Mus sp.

<400> 23
Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 24
<211> 10
<212> PRT
<213> Mus sp.

<400> 24
Ser Tyr Tyr Arg Tyr Asp Gly Met Asp Tyr 
1               5                   10  


<210> 25
<211> 121
<212> PRT
<213> Mus sp.

<400> 25
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Tyr Tyr Arg Tyr Asp Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210> 26
<211> 22
<212> PRT
<213> Mus sp.

<400> 26
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Val Ser Arg Gly 
            20          


<210> 27
<211> 10
<212> PRT
<213> Mus sp.

<400> 27
Ser Ala Ile Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210> 28
<211> 7
<212> PRT
<213> Mus sp.

<400> 28
Asp Thr Ser Asn Leu Val Ser 
1               5           


<210> 29
<211> 9
<212> PRT
<213> Mus sp.

<400> 29
Gln Gln Trp Asn Thr Tyr Pro Tyr Thr 
1               5                   


<210> 30
<211> 106
<212> PRT
<213> Mus sp.

<400> 30
Gln Val Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ile Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Val Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210> 31
<211> 18
<212> PRT
<213> Mus sp.

<400> 31
Met Arg Val Leu Ile Leu Val Tyr Leu Leu Thr Val Leu Pro Gly Ile 
1               5                   10                  15      


Leu Ser 
        


<210> 32
<211> 7
<212> PRT
<213> Mus sp.

<400> 32
Asn Asp Asn His Trp Trp Asn 
1               5           


<210> 33
<211> 16
<212> PRT
<213> Mus sp.

<400> 33
Tyr Ile Asp Ser Ser Gly Ser Ser Asp Asn Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 34
<211> 11
<212> PRT
<213> Mus sp.

<400> 34
Gly Gly Gly Arg Asp Tyr Tyr Gly Met Asp Tyr 
1               5                   10      


<210> 35
<211> 121
<212> PRT
<213> Mus sp.

<400> 35
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Val Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Asn Asp 
            20                  25                  30          


Asn His Trp Trp Asn Trp Ile Arg Gln Val Ser Gly Ser Lys Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Ile Asp Ser Ser Gly Ser Ser Asp Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Ile Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Gly Arg Asp Tyr Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210> 36
<211> 20
<212> PRT
<213> Mus sp.

<400> 36
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210> 37
<211> 15
<212> PRT
<213> Mus sp.

<400> 37
Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Val His 
1               5                   10                  15  


<210> 38
<211> 7
<212> PRT
<213> Mus sp.

<400> 38
Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210> 39
<211> 9
<212> PRT
<213> Mus sp.

<400> 39
Gln His Ser Trp Asp Ile Pro Phe Thr 
1               5                   


<210> 40
<211> 111
<212> PRT
<213> Mus sp.

<400> 40
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Asp Ile Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210> 41
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Tyr Tyr Arg Tyr Asp Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 42
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ile Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Val Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Asn Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 43
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Asn Asp 
            20                  25                  30          


Asn His Trp Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Ile Asp Ser Ser Gly Ser Ser Asp Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Gly Arg Asp Tyr Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 44
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Asp Ile Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210> 45
<211> 126
<212> PRT
<213> Homo sapiens

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp His 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Thr Arg Asp Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Gly Ala Ala Met Ala Arg Gly Tyr Gln Asp Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 46
<211> 107
<212> PRT
<213> Homo sapiens

<400> 46
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Lys Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Lys Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 47
<211> 122
<212> PRT
<213> Homo sapiens

<400> 47
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asp Asn Thr 
            20                  25                  30          


Gly Phe Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Trp Gly Asn Ser Trp Asp Arg Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 48
<211> 114
<212> PRT
<213> Homo sapiens

<400> 48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210> 49
<211> 101
<212> PRT
<213> Homo sapiens

<400> 49
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe 
            100     


<210> 50
<211> 113
<212> PRT
<213> Homo sapiens

<400> 50
Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
1               5                   10                  15      


Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
            20                  25                  30          


Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
        35                  40                  45              


His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
    50                  55                  60                  


Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
65                  70                  75                  80  


Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                85                  90                  95      


Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp 
            100                 105                 110         


Thr 
    


<210> 51
<211> 102
<212> PRT
<213> Mus sp.

<400> 51
Ala Val Lys Asn Cys Ser His Leu Glu Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Val Ser Cys Met Trp Ser His Glu Glu Ala Leu Asn Val Thr Thr 
            20                  25                  30          


Cys His Val His Ala Lys Ser Asn Leu Arg His Trp Asn Lys Thr Cys 
        35                  40                  45              


Glu Leu Thr Leu Val Arg Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ser Phe Pro Glu Ser Gln Ser Leu Thr Ser Val Asp Leu Leu Asp 
65                  70                  75                  80  


Ile Asn Val Val Cys Trp Glu Glu Lys Gly Trp Arg Arg Val Lys Thr 
                85                  90                  95      


Cys Asp Phe His Pro Phe 
            100         


<210> 52
<211> 113
<212> PRT
<213> Mus sp.

<400> 52
Asp Asn Leu Arg Leu Val Ala Pro His Ser Leu Gln Val Leu His Ile 
1               5                   10                  15      


Asp Thr Gln Arg Cys Asn Ile Ser Trp Lys Val Ser Gln Val Ser His 
            20                  25                  30          


Tyr Ile Glu Pro Tyr Leu Glu Phe Glu Ala Arg Arg Arg Leu Leu Gly 
        35                  40                  45              


His Ser Trp Glu Asp Ala Ser Val Leu Ser Leu Lys Gln Arg Gln Gln 
    50                  55                  60                  


Trp Leu Phe Leu Glu Met Leu Ile Pro Ser Thr Ser Tyr Glu Val Gln 
65                  70                  75                  80  


Val Arg Val Lys Ala Gln Arg Asn Asn Thr Gly Thr Trp Ser Pro Trp 
                85                  90                  95      


Ser Gln Pro Leu Thr Phe Arg Thr Arg Pro Ala Asp Pro Met Lys Glu 
            100                 105                 110         


Ile 
    


<210> 53
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Thr Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Pro 
1               5                   10                  15      


Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly 
            20                  25                  30          


His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met 
        35                  40                  45              


Gly Leu Leu Thr 
    50          


<210> 54
<211> 214
<212> PRT
<213> Homo sapiens

<400> 54
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 55
<211> 214
<212> PRT
<213> Homo sapiens

<400> 55
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Lys Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 56
<211> 214
<212> PRT
<213> Homo sapiens

<400> 56
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Ser Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 57
<211> 214
<212> PRT
<213> Homo sapiens

<400> 57
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Ala Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 58
<211> 214
<212> PRT
<213> Homo sapiens

<400> 58
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Ala Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 59
<211> 214
<212> PRT
<213> Homo sapiens

<400> 59
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Ala Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 60
<211> 214
<212> PRT
<213> Homo sapiens

<400> 60
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Ala Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 61
<211> 214
<212> PRT
<213> Homo sapiens

<400> 61
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Ala Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 62
<211> 214
<212> PRT
<213> Homo sapiens

<400> 62
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Ala 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 63
<211> 214
<212> PRT
<213> Homo sapiens

<400> 63
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Ala Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 64
<211> 214
<212> PRT
<213> Homo sapiens

<400> 64
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Thr Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 65
<211> 214
<212> PRT
<213> Homo sapiens

<400> 65
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ser Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 66
<211> 214
<212> PRT
<213> Homo sapiens

<400> 66
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ala Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 67
<211> 214
<212> PRT
<213> Homo sapiens

<400> 67
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Ala Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 68
<211> 214
<212> PRT
<213> Homo sapiens

<400> 68
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Lys Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 69
<211> 214
<212> PRT
<213> Homo sapiens

<400> 69
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Ala Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 70
<211> 214
<212> PRT
<213> Homo sapiens

<400> 70
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ala His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 71
<211> 214
<212> PRT
<213> Homo sapiens

<400> 71
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser Ala Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 72
<211> 214
<212> PRT
<213> Homo sapiens

<400> 72
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Ala Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210> 73
<211> 525
<212> PRT
<213> Homo sapiens

<400> 73
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
    210                 215                 220                 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
225                 230                 235                 240 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
                245                 250                 255     


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
            260                 265                 270         


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
        275                 280                 285             


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
    290                 295                 300                 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
305                 310                 315                 320 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
                325                 330                 335     


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            340                 345                 350         


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        355                 360                 365             


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    370                 375                 380                 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
385                 390                 395                 400 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                405                 410                 415     


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            420                 425                 430         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        435                 440                 445             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    450                 455                 460                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
465                 470                 475                 480 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                485                 490                 495     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            500                 505                 510         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 525 


<210> 74
<211> 525
<212> PRT
<213> Homo sapiens

<400> 74
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Ala Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
    210                 215                 220                 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
225                 230                 235                 240 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
                245                 250                 255     


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
            260                 265                 270         


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
        275                 280                 285             


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
    290                 295                 300                 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
305                 310                 315                 320 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
                325                 330                 335     


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            340                 345                 350         


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        355                 360                 365             


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    370                 375                 380                 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
385                 390                 395                 400 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                405                 410                 415     


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            420                 425                 430         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        435                 440                 445             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    450                 455                 460                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
465                 470                 475                 480 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                485                 490                 495     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            500                 505                 510         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 525 


<210> 75
<211> 525
<212> PRT
<213> Homo sapiens

<400> 75
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Ala Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
    210                 215                 220                 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
225                 230                 235                 240 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
                245                 250                 255     


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
            260                 265                 270         


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
        275                 280                 285             


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
    290                 295                 300                 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
305                 310                 315                 320 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
                325                 330                 335     


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            340                 345                 350         


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        355                 360                 365             


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    370                 375                 380                 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
385                 390                 395                 400 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                405                 410                 415     


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            420                 425                 430         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        435                 440                 445             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    450                 455                 460                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
465                 470                 475                 480 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                485                 490                 495     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            500                 505                 510         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 525 


<210> 76
<211> 525
<212> PRT
<213> Homo sapiens

<400> 76
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Thr Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
    210                 215                 220                 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
225                 230                 235                 240 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
                245                 250                 255     


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
            260                 265                 270         


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
        275                 280                 285             


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
    290                 295                 300                 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
305                 310                 315                 320 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
                325                 330                 335     


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            340                 345                 350         


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        355                 360                 365             


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    370                 375                 380                 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
385                 390                 395                 400 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                405                 410                 415     


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            420                 425                 430         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        435                 440                 445             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    450                 455                 460                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
465                 470                 475                 480 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                485                 490                 495     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            500                 505                 510         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 525 


<210> 77
<211> 525
<212> PRT
<213> Homo sapiens

<400> 77
Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser Ala Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly 
    210                 215                 220                 


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
225                 230                 235                 240 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
                245                 250                 255     


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
            260                 265                 270         


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
        275                 280                 285             


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
    290                 295                 300                 


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
305                 310                 315                 320 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
                325                 330                 335     


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            340                 345                 350         


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        355                 360                 365             


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    370                 375                 380                 


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
385                 390                 395                 400 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                405                 410                 415     


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            420                 425                 430         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        435                 440                 445             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    450                 455                 460                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
465                 470                 475                 480 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                485                 490                 495     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            500                 505                 510         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 525 



