                         SEQUENCE LISTING

<110>  National Foundaton For Fertility Research
 
<120>  SECRETOME PROFILE-FACILITATED IN VITRO FERTILIZATION

<130>  500987

<150>  61/321,448
<151>  2010-04-06

<160>  404   

<170>  PatentIn version 3.5

<210>  1
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  2
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val 
        35                  40                  45              


Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr 
    50                  55                  60                  


Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr 
65                  70                  75                  80  


Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr 
            100                 105                 110         


Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met 
        115                 120                 125             


Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu 
145                 150                 155                 160 


Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu 
                245                 250                 255     


Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala 
            260                 265                 270         


Arg Ser Met Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe 
    290                 295                 300                 


Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly 
305                 310                 315                 320 


Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr 
                325                 330                 335     


Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu 
            340                 345                 350         


Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His 
        355                 360                 365             


His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys 
    370                 375                 380                 


Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile 
385                 390                 395                 400 


Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr 
                405                 410                 415     


Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn 
            420                 425                 430         


Lys Ser Asp Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Ile 
        435                 440                 445             


Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys 
    450                 455                 460                 


Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn 
465                 470                 475                 480 


Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp 
                485                 490                 495     


Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser 
            500                 505                 510         


Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn 
        515                 520                 525             


Asn Lys Glu Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val 
    530                 535                 540                 


Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn 
545                 550                 555                 560 


Thr Gly Gly Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys 
                565                 570                 575     


Asp Tyr Glu Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu 
            580                 585                 590         


Tyr Ala Asn Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr 
        595                 600                 605             


Arg Lys Asp Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln 
    610                 615                 620                 


His Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys 
                645                 650                 655     


Leu Ala Lys Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu 
            660                 665                 670         


Glu Tyr Val Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser 
        675                 680                 685             


Leu Leu Glu Ala Cys Thr Phe Arg Arg Pro 
    690                 695             


<210>  3
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             


Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 


Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 


Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     


Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         


Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             


Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 


Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 


Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     


Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         


Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             


Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 


Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 


Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     


His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         


Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             


Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 


Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 


Lys Thr Ile Ala Glu Asn 
                405     


<210>  4
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  5
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210>  6
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  7
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  8
<211>  1065
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
            20                  25                  30          


Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
        35                  40                  45              


Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
    50                  55                  60                  


Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
65                  70                  75                  80  


Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                85                  90                  95      


Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
            100                 105                 110         


Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
        115                 120                 125             


Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
    130                 135                 140                 


Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
145                 150                 155                 160 


Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                165                 170                 175     


Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
            180                 185                 190         


Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
        195                 200                 205             


Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
    210                 215                 220                 


Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
225                 230                 235                 240 


Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                245                 250                 255     


Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
            260                 265                 270         


Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
        275                 280                 285             


Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
    290                 295                 300                 


Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
305                 310                 315                 320 


Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                325                 330                 335     


Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
            340                 345                 350         


Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
        355                 360                 365             


Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
    370                 375                 380                 


Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
385                 390                 395                 400 


Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                405                 410                 415     


Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
            420                 425                 430         


Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
        435                 440                 445             


Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
    450                 455                 460                 


Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
465                 470                 475                 480 


Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                485                 490                 495     


Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
            500                 505                 510         


Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
        515                 520                 525             


Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp 
    530                 535                 540                 


Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
545                 550                 555                 560 


Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                565                 570                 575     


Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
            580                 585                 590         


Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
        595                 600                 605             


Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 
    610                 615                 620                 


Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 
625                 630                 635                 640 


Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 
                645                 650                 655     


Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg 
            660                 665                 670         


Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp 
        675                 680                 685             


Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His 
    690                 695                 700                 


Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg 
705                 710                 715                 720 


Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 
                725                 730                 735     


Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 
            740                 745                 750         


Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 
        755                 760                 765             


Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 
    770                 775                 780                 


Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala 
785                 790                 795                 800 


Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val 
                805                 810                 815     


Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr 
            820                 825                 830         


Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro 
        835                 840                 845             


Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 
    850                 855                 860                 


Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 
865                 870                 875                 880 


Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 
                885                 890                 895     


Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 
            900                 905                 910         


Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 
        915                 920                 925             


Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 
    930                 935                 940                 


Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala 
945                 950                 955                 960 


Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val 
                965                 970                 975     


Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 
            980                 985                 990         


Leu His Thr Val His Phe His Gly  His Ser Phe Gln Tyr  Lys His Arg 
        995                 1000                 1005             


Gly Val  Tyr Ser Ser Asp Val  Phe Asp Ile Phe Pro  Gly Thr Tyr 
    1010                 1015                 1020             


Gln Thr  Leu Glu Met Phe Pro  Arg Thr Pro Gly Ile  Trp Leu Leu 
    1025                 1030                 1035             


His Cys  His Val Thr Asp His  Ile His Ala Gly Met  Glu Thr Thr 
    1040                 1045                 1050             


Tyr Thr  Val Leu Gln Asn Glu  Asp Thr Lys Ser Gly  
    1055                 1060                 1065 


<210>  9
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Lys Glu Leu Ala Lys Leu Val Asn Lys Arg Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210>  10
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro 
            420 


<210>  11
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  12
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly 
1               5                   10                  15      


Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp 
            20                  25                  30          


Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr Leu Thr 
        35                  40                  45              


Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys Asn Gly 
    50                  55                  60                  


Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys His Gln 
65                  70                  75                  80  


Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg Ser Gly 
                85                  90                  95      


Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys Leu Leu Glu Leu Thr Gly 
            100                 105                 110         


Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val Ser Trp 
        115                 120                 125             


Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg 
    130                 135                 140                 


Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu 
145                 150                 155                 160 


Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val His Gln 
                165                 170                 175     


Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly Ala Leu 
            180                 185                 190         


Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Ala Ala Pro Pro 
        195                 200                 205             


Pro Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro 
    210                 215                 220                 


Gly Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp 
225                 230                 235                 240 


Phe Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser 
                245                 250                 255     


Thr Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly 
            260                 265                 270         


Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn 
        275                 280                 285             


Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu 
    290                 295                 300                 


Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala 
305                 310                 315                 320 


Leu Arg Leu Arg Cys Leu Ala Pro Leu Glu Gly Ala Arg Phe Ala Leu 
                325                 330                 335     


Val Arg Glu Asp Arg Gly Gly Arg Arg Val His Arg Phe Gln Ser Pro 
            340                 345                 350         


Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp 
        355                 360                 365             


Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly 
    370                 375                 380                 


Gly Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro 
385                 390                 395                 400 


Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Val Leu Ala Gly 
                405                 410                 415     


Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp Val Thr Phe 
            420                 425                 430         


Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val Lys Thr Val Arg Thr 
        435                 440                 445             


Pro Gly Ala Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His 
    450                 455                 460                 


Ala Gly Asn Tyr Arg Cys Arg Tyr Arg Ser Trp Val Pro His Thr Phe 
465                 470                 475                 480 


Glu Ser Glu Leu Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser 
                485                 490                 495 


<210>  13
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  14
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro 
        35                  40                  45              


Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu 
    50                  55                  60                  


Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val 
65                  70                  75                  80  


Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 
                85                  90                  95      


His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 
            100                 105                 110         


Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 
        115                 120                 125             


Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 
    130                 135                 140                 


Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys 
145                 150                 155                 160 


Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn 
                165                 170                 175     


Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp 
            180                 185                 190         


Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys 
        195                 200                 205             


Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 
    210                 215                 220                 


Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 
225                 230                 235                 240 


Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 
                245                 250                 255     


Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr 
            260                 265                 270         


Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly 
        275                 280                 285             


Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu 
    290                 295                 300                 


Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro 
305                 310                 315                 320 


Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu 
                325                 330                 335     


Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met 
            340                 345                 350         


Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 
        355                 360                 365             


Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 
    370                 375                 380                 


Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe 
385                 390                 395                 400 


His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala 
                405                 410                 415     


Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val 
            420                 425                 430         


Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro 
        435                 440                 445             


Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys 
    450                 455                 460                 


<210>  15
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210>  16
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser 
1               5                   10                  15      


Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala 
            20                  25                  30          


Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu 
        35                  40                  45              


Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 
    50                  55                  60                  


Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp 
65                  70                  75                  80  


Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 
                85                  90                  95      


Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe 
            100                 105                 110         


Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val 
        115                 120                 125             


His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala 
    130                 135                 140                 


Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala 
145                 150                 155                 160 


Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp 
                165                 170                 175     


Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val 
            180                 185                 190         


Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val 
        195                 200                 205             


Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val 
    210                 215                 220                 


Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp 
225                 230                 235                 240 


Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 
                245                 250                 255     


Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val 
            260                 265                 270         


Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met 
        275                 280                 285             


Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn 
    290                 295                 300                 


Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln 
305                 310                 315                 320 


His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe 
                325                 330                 335     


Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp 
            340                 345                 350         


Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp 
        355                 360                 365             


Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu 
    370                 375                 380                 


Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn 
                405                 410                 415     


Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu 
            420                 425                 430         


Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys 
        435                 440                 445             


Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val 
    450                 455                 460                 


Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn 
465                 470                 475                 480 


Pro Leu Ser Thr Ala 
                485 


<210>  17
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  18
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe 
    610                 615                 620                 


Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Glu Ala Ser 
625                 630                 635                 640 


Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser 
                645                 650                 655     


Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 
        675                 680                 685             


Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro 
    690                 695                 700                 


Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu Thr Thr 
705                 710                 715                 720 


Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu 
                725                 730                 735     


Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His 
            740                 745                 750         


Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu 
        755                 760                 765             


Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu 
    770                 775                 780                 


Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His 
785                 790                 795                 800 


Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu 
                805                 810                 815     


Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr 
            820                 825                 830         


Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu 
        835                 840                 845             


Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr 
    850                 855                 860                 


Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln 
865                 870                 875                 880 


Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr 
                885                 890                 895     


Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu 
            900                 905                 910         


Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val 
        915                 920                 925             


Glu Leu 
    930 


<210>  19
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  20
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  21
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  22
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  23
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Lys His Ser Leu Asn Ala Leu Leu Ile Phe Leu Ile Ile Thr Ser 
1               5                   10                  15      


Ala Trp Gly Gly Ser Lys Gly Pro Leu Asp Gln Leu Glu Lys Gly Gly 
            20                  25                  30          


Glu Thr Ala Gln Ser Ala Asp Pro Gln Trp Glu Gln Leu Asn Asn Lys 
        35                  40                  45              


Asn Leu Ser Met Pro Leu Leu Pro Ala Asp Phe His Lys Glu Asn Thr 
    50                  55                  60                  


Val Thr Asn Asp Trp Ile Pro Glu Gly Glu Glu Asp Asp Asp Tyr Leu 
65                  70                  75                  80  


Asp Leu Glu Lys Ile Phe Ser Glu Asp Asp Asp Tyr Ile Asp Ile Val 
                85                  90                  95      


Asp Ser Leu Ser Val Ser Pro Thr Asp Ser Asp Val Ser Ala Gly Asn 
            100                 105                 110         


Ile Leu Gln Leu Phe His Gly Lys Ser Arg Ile Gln Arg Leu Asn Ile 
        115                 120                 125             


Leu Asn Ala Lys Phe Ala Phe Asn Leu Tyr Arg Val Leu Lys Asp Gln 
    130                 135                 140                 


Val Asn Thr Phe Asp Asn Ile Phe Ile Ala Pro Val Gly Ile Ser Thr 
145                 150                 155                 160 


Ala Met Gly Met Ile Ser Leu Gly Leu Lys Gly Glu Thr His Glu Gln 
                165                 170                 175     


Val His Ser Ile Leu His Phe Lys Asp Phe Val Asn Ala Ser Ser Lys 
            180                 185                 190         


Tyr Glu Ile Thr Thr Ile His Asn Leu Phe Arg Lys Leu Thr His Arg 
        195                 200                 205             


Leu Phe Arg Arg Asn Phe Gly Tyr Thr Leu Arg Ser Val Asn Asp Leu 
    210                 215                 220                 


Tyr Ile Gln Lys Gln Phe Pro Ile Leu Leu Asp Phe Lys Thr Lys Val 
225                 230                 235                 240 


Arg Glu Tyr Tyr Phe Ala Glu Ala Gln Ile Ala Asp Phe Ser Asp Pro 
                245                 250                 255     


Ala Phe Ile Ser Lys Thr Asn Asn His Ile Met Lys Leu Thr Lys Gly 
            260                 265                 270         


Leu Ile Lys Asp Ala Leu Glu Asn Ile Asp Pro Ala Thr Gln Met Met 
        275                 280                 285             


Ile Leu Asn Cys Ile Tyr Phe Lys Gly Ser Trp Val Asn Lys Phe Pro 
    290                 295                 300                 


Val Glu Met Thr His Asn His Asn Phe Arg Leu Asn Glu Arg Glu Val 
305                 310                 315                 320 


Val Lys Val Ser Met Met Gln Thr Lys Gly Asn Phe Leu Ala Ala Asn 
                325                 330                 335     


Asp Gln Glu Leu Asp Cys Asp Ile Leu Gln Leu Glu Tyr Val Gly Gly 
            340                 345                 350         


Ile Ser Met Leu Ile Val Val Pro His Lys Met Ser Gly Met Lys Thr 
        355                 360                 365             


Leu Glu Ala Gln Leu Thr Pro Arg Val Val Glu Arg Trp Gln Lys Ser 
    370                 375                 380                 


Met Thr Asn Arg Thr Arg Glu Val Leu Leu Pro Lys Phe Lys Leu Glu 
385                 390                 395                 400 


Lys Asn Tyr Asn Leu Val Glu Ser Leu Lys Leu Met Gly Ile Arg Met 
                405                 410                 415     


Leu Phe Asp Lys Asn Gly Asn Met Ala Gly Ile Ser Asp Gln Arg Ile 
            420                 425                 430         


Ala Ile Asp Leu Phe Lys His Gln Gly Thr Ile Thr Val Asn Glu Glu 
        435                 440                 445             


Gly Thr Gln Ala Thr Thr Val Thr Thr Val Gly Phe Met Pro Leu Ser 
    450                 455                 460                 


Thr Gln Val Arg Phe Thr Val Asp Arg Pro Phe Leu Phe Leu Ile Tyr 
465                 470                 475                 480 


Glu His Arg Thr Ser Cys Leu Leu Phe Met Gly Arg Val Ala Asn Pro 
                485                 490                 495     


Ser Arg Ser 
            


<210>  24
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  25
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  26
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser 
1               5                   10                  15      


Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln 
            20                  25                  30          


Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His 
        35                  40                  45              


Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 
    50                  55                  60                  


Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu 
65                  70                  75                  80  


Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 
                85                  90                  95      


Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu 
            100                 105                 110         


Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu 
        115                 120                 125             


Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser 
    130                 135                 140                 


Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala 
145                 150                 155                 160 


Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly 
                165                 170                 175     


Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala 
            180                 185                 190         


Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala 
        195                 200                 205             


Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala 
    210                 215                 220                 


Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His 
225                 230                 235                 240 


Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg 
                245                 250                 255     


Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe 
            260                 265                 270         


Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg 
        275                 280                 285             


Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr 
    290                 295                 300                 


Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg 
305                 310                 315                 320 


Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val 
                325                 330                 335     


Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln 
            340                 345                 350         


Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala 
        355                 360                 365             


Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro 
    370                 375                 380                 


Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala 
                405                 410                 415     


Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met 
            420                 425                 430         


Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser 
        435                 440                 445             


Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His 
    450                 455                 460                 


Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val 
465                 470                 475                 480 


Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu 
                485                 490                 495     


Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu 
            500                 505                 510         


Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr 
        515                 520                 525             


Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His 
    530                 535                 540                 


Phe Thr Ala Thr Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg 
545                 550                 555                 560 


Ser Arg Arg Glu Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln 
                565                 570                 575     


<210>  27
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Thr Cys Thr Val Phe Gln Thr Gln Pro Val Thr 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210>  28
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Val Ser Pro Pro His Thr Ser Met Ala Pro Ala Gln Asp Glu Glu 
                405                 410                 415     


Arg Asp Ser Gly Lys Glu Gln Gly His Thr Arg Arg His Asp Trp Gly 
            420                 425                 430         


His Glu Lys Gln Arg Lys His Asn Leu Gly His Gly His Lys His Glu 
        435                 440                 445             


Arg Asp Gln Gly His Gly His Gln Arg Gly His Gly Leu Gly His Gly 
    450                 455                 460                 


His Glu Gln Gln His Gly Leu Gly His Gly His Lys Phe Lys Leu Asp 
465                 470                 475                 480 


Asp Asp Leu Glu His Gln Gly Gly His Val Leu Asp His Gly His Lys 
                485                 490                 495     


His Lys His Gly His Gly His Gly Lys His Lys Asn Lys Gly Lys Lys 
            500                 505                 510         


Asn Gly Lys His Asn Gly Trp Lys Thr Glu His Leu Ala Ser Ser Ser 
        515                 520                 525             


Glu Asp Ser Thr Thr Pro Ser Ala Gln Thr Gln Glu Lys Thr Glu Gly 
    530                 535                 540                 


Pro Thr Pro Ile Pro Ser Leu Ala Lys Pro Gly Val Thr Val Thr Phe 
545                 550                 555                 560 


Ser Asp Phe Gln Asp Ser Asp Leu Ile Ala Thr Met Met Pro Pro Ile 
                565                 570                 575     


Ser Pro Ala Pro Ile Gln Ser Asp Asp Asp Trp Ile Pro Asp Ile Gln 
            580                 585                 590         


Ile Asp Pro Asn Gly Leu Ser Phe Asn Pro Ile Ser Asp Phe Pro Asp 
        595                 600                 605             


Thr Thr Ser Pro Lys Cys Pro Gly Arg Pro Trp Lys Ser Val Ser Glu 
    610                 615                 620                 


Ile Asn Pro Thr Thr Gln Met Lys Glu Ser Tyr Tyr Phe Asp Leu Thr 
625                 630                 635                 640 


Asp Gly Leu Ser 
                


<210>  29
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  30
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Pro Phe Leu Tyr Leu Val Leu Leu Val Leu Gly Leu His Ala 
1               5                   10                  15      


Thr Ile His Cys Ala Ser Pro Glu Gly Lys Val Thr Ala Cys His Ser 
            20                  25                  30          


Ser Gln Pro Asn Ala Thr Leu Tyr Lys Met Ser Ser Ile Asn Ala Asp 
        35                  40                  45              


Phe Ala Phe Asn Leu Tyr Arg Arg Phe Thr Val Glu Thr Pro Asp Lys 
    50                  55                  60                  


Asn Ile Phe Phe Ser Pro Val Ser Ile Ser Ala Ala Leu Val Met Leu 
65                  70                  75                  80  


Ser Phe Gly Ala Cys Cys Ser Thr Gln Thr Glu Ile Val Glu Thr Leu 
                85                  90                  95      


Gly Phe Asn Leu Thr Asp Thr Pro Met Val Glu Ile Gln His Gly Phe 
            100                 105                 110         


Gln His Leu Ile Cys Ser Leu Asn Phe Pro Lys Lys Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Gly Asn Ala Leu Phe Ile Gly Lys His Leu Lys Pro Leu Ala 
    130                 135                 140                 


Lys Phe Leu Asn Asp Val Lys Thr Leu Tyr Glu Thr Glu Val Phe Ser 
145                 150                 155                 160 


Thr Asp Phe Ser Asn Ile Ser Ala Ala Lys Gln Glu Ile Asn Ser His 
                165                 170                 175     


Val Glu Met Gln Thr Lys Gly Lys Val Val Gly Leu Ile Gln Asp Leu 
            180                 185                 190         


Lys Pro Asn Thr Ile Met Val Leu Val Asn Tyr Ile His Phe Lys Ala 
        195                 200                 205             


Gln Trp Ala Asn Pro Phe Asp Pro Ser Lys Thr Glu Asp Ser Ser Ser 
    210                 215                 220                 


Phe Leu Ile Asp Lys Thr Thr Thr Val Gln Val Pro Met Met His Gln 
225                 230                 235                 240 


Met Glu Gln Tyr Tyr His Leu Val Asp Met Glu Leu Asn Cys Thr Val 
                245                 250                 255     


Leu Gln Met Asp Tyr Ser Lys Asn Ala Leu Ala Leu Phe Val Leu Pro 
            260                 265                 270         


Lys Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys Thr 
        275                 280                 285             


Leu Lys Lys Trp Asn Arg Leu Leu Gln Lys Gly Trp Val Asp Leu Phe 
    290                 295                 300                 


Val Pro Lys Phe Ser Ile Ser Ala Thr Tyr Asp Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Leu Lys Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser 
                325                 330                 335     


Gly Leu Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys 
            340                 345                 350         


Ala Val Leu His Ile Gly Glu Lys Gly Thr Glu Ala Ala Ala Val Pro 
        355                 360                 365             


Glu Val Glu Leu Ser Asp Gln Pro Glu Asn Thr Phe Leu His Pro Ile 
    370                 375                 380                 


Ile Gln Ile Asp Arg Ser Phe Met Leu Leu Ile Leu Glu Arg Ser Thr 
385                 390                 395                 400 


Arg Ser Ile Leu Phe Leu Gly Lys Val Val Asn Pro Thr Glu Ala 
                405                 410                 415 


<210>  31
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Leu Leu Leu Tyr Thr Cys Leu Leu Trp Leu Pro Thr Ser Gly 
1               5                   10                  15      


Leu Trp Thr Val Gln Ala Met Asp Pro Asn Ala Ala Tyr Val Asn Met 
            20                  25                  30          


Ser Asn His His Arg Gly Leu Ala Ser Ala Asn Val Asp Phe Ala Phe 
        35                  40                  45              


Ser Leu Tyr Lys His Leu Val Ala Leu Ser Pro Lys Lys Asn Ile Phe 
    50                  55                  60                  


Ile Ser Pro Val Ser Ile Ser Met Ala Leu Ala Met Leu Ser Leu Gly 
65                  70                  75                  80  


Thr Cys Gly His Thr Arg Ala Gln Leu Leu Gln Gly Leu Gly Phe Asn 
                85                  90                  95      


Leu Thr Glu Arg Ser Glu Thr Glu Ile His Gln Gly Phe Gln His Leu 
            100                 105                 110         


His Gln Leu Phe Ala Lys Ser Asp Thr Ser Leu Glu Met Thr Met Gly 
        115                 120                 125             


Asn Ala Leu Phe Leu Asp Gly Ser Leu Glu Leu Leu Glu Ser Phe Ser 
    130                 135                 140                 


Ala Asp Ile Lys His Tyr Tyr Glu Ser Glu Val Leu Ala Met Asn Phe 
145                 150                 155                 160 


Gln Asp Trp Ala Thr Ala Ser Arg Gln Ile Asn Ser Tyr Val Lys Asn 
                165                 170                 175     


Lys Thr Gln Gly Lys Ile Val Asp Leu Phe Ser Gly Leu Asp Ser Pro 
            180                 185                 190         


Ala Ile Leu Val Leu Val Asn Tyr Ile Phe Phe Lys Gly Thr Trp Thr 
        195                 200                 205             


Gln Pro Phe Asp Leu Ala Ser Thr Arg Glu Glu Asn Phe Tyr Val Asp 
    210                 215                 220                 


Glu Thr Thr Val Val Lys Val Pro Met Met Leu Gln Ser Ser Thr Ile 
225                 230                 235                 240 


Ser Tyr Leu His Asp Ser Glu Leu Pro Cys Gln Leu Val Gln Met Asn 
                245                 250                 255     


Tyr Val Gly Asn Gly Thr Val Phe Phe Ile Leu Pro Asp Lys Gly Lys 
            260                 265                 270         


Met Asn Thr Val Ile Ala Ala Leu Ser Arg Asp Thr Ile Asn Arg Trp 
        275                 280                 285             


Ser Ala Gly Leu Thr Ser Ser Gln Val Asp Leu Tyr Ile Pro Lys Val 
    290                 295                 300                 


Thr Ile Ser Gly Val Tyr Asp Leu Gly Asp Val Leu Glu Glu Met Gly 
305                 310                 315                 320 


Ile Ala Asp Leu Phe Thr Asn Gln Ala Asn Phe Ser Arg Ile Thr Gln 
                325                 330                 335     


Asp Ala Gln Leu Lys Ser Ser Lys Val Val His Lys Ala Val Leu Gln 
            340                 345                 350         


Leu Asn Glu Glu Gly Val Asp Thr Ala Gly Ser Thr Gly Val Thr Leu 
        355                 360                 365             


Asn Leu Thr Ser Lys Pro Ile Ile Leu Arg Phe Asn Gln Pro Phe Ile 
    370                 375                 380                 


Ile Met Ile Phe Asp His Phe Thr Trp Ser Ser Leu Phe Leu Ala Arg 
385                 390                 395                 400 


Val Met Asn Pro Val 
                405 


<210>  32
<211>  1429
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr 
1               5                   10                  15      


Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp 
            20                  25                  30          


Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg 
        35                  40                  45              


Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu 
    50                  55                  60                  


Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala 
                85                  90                  95      


Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn 
            100                 105                 110         


Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln 
        115                 120                 125             


Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe 
    130                 135                 140                 


Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp 
145                 150                 155                 160 


Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His 
                165                 170                 175     


Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp 
            180                 185                 190         


Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro 
        195                 200                 205             


Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly 
    210                 215                 220                 


Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly 
225                 230                 235                 240 


Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly 
                245                 250                 255     


Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu 
            260                 265                 270         


Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr 
        275                 280                 285             


Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val 
    290                 295                 300                 


Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val 
305                 310                 315                 320 


Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn 
                325                 330                 335     


Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile 
            340                 345                 350         


Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met 
        355                 360                 365             


Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg 
    370                 375                 380                 


Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr 
385                 390                 395                 400 


Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn 
                405                 410                 415     


Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val 
            420                 425                 430         


Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser 
        435                 440                 445             


Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile 
    450                 455                 460                 


Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr 
465                 470                 475                 480 


Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu 
                485                 490                 495     


Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg 
            500                 505                 510         


Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr 
        515                 520                 525             


Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp 
    530                 535                 540                 


Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val 
545                 550                 555                 560 


Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp 
                565                 570                 575     


Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala 
            580                 585                 590         


Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu 
        595                 600                 605             


His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser 
    610                 615                 620                 


Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile 
625                 630                 635                 640 


Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala 
                645                 650                 655     


Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser 
            660                 665                 670         


Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys 
        675                 680                 685             


Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys 
    690                 695                 700                 


Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys 
705                 710                 715                 720 


His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu 
                725                 730                 735     


Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro 
            740                 745                 750         


Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp 
        755                 760                 765             


Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro 
    770                 775                 780                 


Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu 
785                 790                 795                 800 


Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys 
                805                 810                 815     


Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val 
            820                 825                 830         


Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met 
        835                 840                 845             


Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val 
    850                 855                 860                 


Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu 
865                 870                 875                 880 


Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu 
                885                 890                 895     


Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro 
            900                 905                 910         


Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln 
        915                 920                 925             


Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser 
    930                 935                 940                 


Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp 
945                 950                 955                 960 


Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp 
                965                 970                 975     


Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr 
            980                 985                 990         


Cys Ser His Cys Leu Glu Gln Pro  Gly Cys Gly Trp Cys  Thr Asp Pro 
        995                 1000                 1005             


Ser Asn  Thr Gly Lys Gly Lys  Cys Ile Glu Gly Ser  Tyr Lys Gly 
    1010                 1015                 1020             


Pro Val  Lys Met Pro Ser Gln  Ala Pro Thr Gly Asn  Phe Tyr Pro 
    1025                 1030                 1035             


Gln Pro  Leu Leu Asn Ser Ser  Met Cys Leu Glu Asp  Ser Arg Tyr 
    1040                 1045                 1050             


Asn Trp  Ser Phe Ile His Cys  Pro Ala Cys Gln Cys  Asn Gly His 
    1055                 1060                 1065             


Ser Lys  Cys Ile Asn Gln Ser  Ile Cys Glu Lys Cys  Glu Asn Leu 
    1070                 1075                 1080             


Thr Thr  Gly Lys His Cys Glu  Thr Cys Ile Ser Gly  Phe Tyr Gly 
    1085                 1090                 1095             


Asp Pro  Thr Asn Gly Gly Lys  Cys Gln Pro Cys Lys  Cys Asn Gly 
    1100                 1105                 1110             


His Ala  Ser Leu Cys Asn Thr  Asn Thr Gly Lys Cys  Phe Cys Thr 
    1115                 1120                 1125             


Thr Lys  Gly Val Lys Gly Asp  Glu Cys Gln Leu Cys  Glu Val Glu 
    1130                 1135                 1140             


Asn Arg  Tyr Gln Gly Asn Pro  Leu Arg Gly Thr Cys  Tyr Tyr Thr 
    1145                 1150                 1155             


Leu Leu  Ile Asp Tyr Gln Phe  Thr Phe Ser Leu Ser  Gln Glu Asp 
    1160                 1165                 1170             


Asp Arg  Tyr Tyr Thr Ala Ile  Asn Phe Val Ala Thr  Pro Asp Glu 
    1175                 1180                 1185             


Gln Asn  Arg Asp Leu Asp Met  Phe Ile Asn Ala Ser  Lys Asn Phe 
    1190                 1195                 1200             


Asn Leu  Asn Ile Thr Trp Ala  Ala Ser Phe Ser Ala  Gly Thr Gln 
    1205                 1210                 1215             


Ala Gly  Glu Glu Met Pro Val  Val Ser Lys Thr Asn  Ile Lys Glu 
    1220                 1225                 1230             


Tyr Lys  Asp Ser Phe Ser Asn  Glu Lys Phe Asp Phe  Arg Asn His 
    1235                 1240                 1245             


Pro Asn  Ile Thr Phe Phe Val  Tyr Val Ser Asn Phe  Thr Trp Pro 
    1250                 1255                 1260             


Ile Lys  Ile Gln Ile Ala Phe  Ser Gln His Ser Asn  Phe Met Asp 
    1265                 1270                 1275             


Leu Val  Gln Phe Phe Val Thr  Phe Phe Ser Cys Phe  Leu Ser Leu 
    1280                 1285                 1290             


Leu Leu  Val Ala Ala Val Val  Trp Lys Ile Lys Gln  Ser Cys Trp 
    1295                 1300                 1305             


Ala Ser  Arg Arg Arg Glu Gln  Leu Leu Arg Glu Met  Gln Gln Met 
    1310                 1315                 1320             


Ala Ser  Arg Pro Phe Ala Ser  Val Asn Val Ala Leu  Glu Thr Asp 
    1325                 1330                 1335             


Glu Glu  Pro Pro Asp Leu Ile  Gly Gly Ser Ile Lys  Thr Val Pro 
    1340                 1345                 1350             


Lys Pro  Ile Ala Leu Glu Pro  Cys Phe Gly Asn Lys  Ala Ala Val 
    1355                 1360                 1365             


Leu Ser  Val Phe Val Arg Leu  Pro Arg Gly Leu Gly  Gly Ile Pro 
    1370                 1375                 1380             


Pro Pro  Gly Gln Ser Gly Leu  Ala Val Ala Ser Ala  Leu Val Asp 
    1385                 1390                 1395             


Ile Ser  Gln Gln Met Pro Ile  Val Tyr Lys Glu Lys  Ser Gly Ala 
    1400                 1405                 1410             


Val Arg  Asn Arg Lys Gln Gln  Pro Pro Ala Gln Pro  Gly Thr Cys 
    1415                 1420                 1425             


Ile 
    


<210>  33
<211>  1482
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Arg Lys Asp Arg Leu Leu His Leu Cys Leu Val Leu Leu Leu Ile 
1               5                   10                  15      


Leu Leu Ser Ala Ser Asp Ser Asn Ser Thr Glu Pro Gln Tyr Met Val 
            20                  25                  30          


Leu Val Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val 
        35                  40                  45              


Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu 
    50                  55                  60                  


Ser Gly Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys 
65                  70                  75                  80  


Asp Leu Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser 
                85                  90                  95      


Ser Glu Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp 
            100                 105                 110         


Phe Arg Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val 
        115                 120                 125             


Phe Val Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Val Arg 
    130                 135                 140                 


Phe Arg Val Val Ser Val Asp Glu Asn Phe Arg Pro Arg Asn Glu Leu 
145                 150                 155                 160 


Ile Pro Leu Ile Tyr Leu Glu Asn Pro Arg Arg Asn Arg Ile Ala Gln 
                165                 170                 175     


Trp Gln Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro 
            180                 185                 190         


Leu Ser Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr 
        195                 200                 205             


Glu Ser Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val 
    210                 215                 220                 


Leu Pro Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile 
225                 230                 235                 240 


Met Asp Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly 
                245                 250                 255     


Lys Pro Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser 
            260                 265                 270         


Arg Val Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln 
        275                 280                 285             


Gln Leu Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met 
    290                 295                 300                 


Leu Gln Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala 
305                 310                 315                 320 


Arg Ile Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile 
                325                 330                 335     


Ser Glu Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp 
            340                 345                 350         


Ser His Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val 
        355                 360                 365             


Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val 
    370                 375                 380                 


Asn Asp Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu 
385                 390                 395                 400 


Ala Gln Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe 
                405                 410                 415     


Val Arg Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp 
            420                 425                 430         


Val Ala Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe 
        435                 440                 445             


Ser Leu Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu 
    450                 455                 460                 


Pro Cys Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg 
465                 470                 475                 480 


Gln Ala Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met 
                485                 490                 495     


Ala Lys Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu 
            500                 505                 510         


Ser Gly Asp Met Lys Gly Ser Phe Ala Leu Ser Phe Pro Val Glu Ser 
        515                 520                 525             


Asp Val Ala Pro Ile Ala Arg Met Phe Ile Phe Ala Ile Leu Pro Asp 
    530                 535                 540                 


Gly Glu Val Val Gly Asp Ser Glu Lys Phe Glu Ile Glu Asn Cys Leu 
545                 550                 555                 560 


Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ala Gln Ser Pro Pro Ala 
                565                 570                 575     


Ser His Ala His Leu Gln Val Ala Ala Ala Pro Gln Ser Leu Cys Ala 
            580                 585                 590         


Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys Pro Glu Ala Glu 
        595                 600                 605             


Leu Ser Val Ser Ser Val Tyr Asn Leu Leu Thr Val Lys Asp Leu Thr 
    610                 615                 620                 


Asn Phe Pro Asp Asn Val Asp Gln Gln Glu Glu Glu Gln Gly His Cys 
625                 630                 635                 640 


Pro Arg Pro Phe Phe Ile His Asn Gly Ala Ile Tyr Val Pro Leu Ser 
                645                 650                 655     


Ser Asn Glu Ala Asp Ile Tyr Ser Phe Leu Lys Gly Met Gly Leu Lys 
            660                 665                 670         


Val Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Ser Cys Ser Val Ile 
        675                 680                 685             


Pro Ser Val Ser Ala Gly Ala Val Gly Gln Gly Tyr Tyr Gly Ala Gly 
    690                 695                 700                 


Leu Gly Val Val Glu Arg Pro Tyr Val Pro Gln Leu Gly Thr Tyr Asn 
705                 710                 715                 720 


Val Ile Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro Val Pro Glu Thr 
                725                 730                 735     


Val Arg Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu Leu Val Ala Val 
            740                 745                 750         


Asn Ser Ser Gly Val Ala Glu Val Gly Val Thr Val Pro Asp Thr Ile 
        755                 760                 765             


Thr Glu Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu 
    770                 775                 780                 


Gly Ile Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe Phe Val 
785                 790                 795                 800 


Glu Leu Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Val Phe Thr Leu 
                805                 810                 815     


Lys Ala Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val Ser Val 
            820                 825                 830         


Gln Leu Lys Ala Ser Pro Ala Phe Leu Ala Ser Gln Asn Thr Lys Gly 
        835                 840                 845             


Glu Glu Ser Tyr Cys Ile Cys Gly Asn Glu Arg Gln Thr Leu Ser Trp 
    850                 855                 860                 


Thr Val Thr Pro Lys Thr Leu Gly Asn Val Asn Phe Ser Val Ser Ala 
865                 870                 875                 880 


Glu Ala Met Gln Ser Leu Glu Leu Cys Gly Asn Glu Val Val Glu Val 
                885                 890                 895     


Pro Glu Ile Lys Arg Lys Asp Thr Val Ile Lys Thr Leu Leu Val Glu 
            900                 905                 910         


Ala Glu Gly Ile Glu Gln Glu Lys Thr Phe Ser Ser Met Thr Cys Ala 
        915                 920                 925             


Ser Gly Ala Asn Val Ser Glu Gln Leu Ser Leu Lys Leu Pro Ser Asn 
    930                 935                 940                 


Val Val Lys Glu Ser Ala Arg Ala Ser Phe Ser Val Leu Gly Asp Ile 
945                 950                 955                 960 


Leu Gly Ser Ala Met Gln Asn Ile Gln Asn Leu Leu Gln Met Pro Tyr 
                965                 970                 975     


Gly Cys Gly Glu Gln Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val 
            980                 985                 990         


Leu Asn Tyr Leu Asn Glu Thr Gln  Gln Leu Thr Gln Glu  Ile Lys Ala 
        995                 1000                 1005             


Lys Ala  Val Gly Tyr Leu Ile  Thr Gly Tyr Gln Arg  Gln Leu Asn 
    1010                 1015                 1020             


Tyr Lys  His Gln Asp Gly Ser  Tyr Ser Thr Phe Gly  Glu Arg Tyr 
    1025                 1030                 1035             


Gly Arg  Asn Gln Gly Asn Thr  Trp Leu Thr Ala Phe  Val Leu Lys 
    1040                 1045                 1050             


Thr Phe  Ala Gln Ala Arg Ser  Tyr Ile Phe Ile Asp  Glu Ala His 
    1055                 1060                 1065             


Ile Thr  Gln Ser Leu Thr Trp  Leu Ser Gln Met Gln  Lys Asp Asn 
    1070                 1075                 1080             


Gly Cys  Phe Arg Ser Ser Gly  Ser Leu Leu Asn Asn  Ala Ile Lys 
    1085                 1090                 1095             


Gly Gly  Val Glu Asp Glu Ala  Thr Leu Ser Ala Tyr  Val Thr Ile 
    1100                 1105                 1110             


Ala Leu  Leu Glu Ile Pro Leu  Pro Val Thr Asn Pro  Ile Val Arg 
    1115                 1120                 1125             


Asn Ala  Leu Phe Cys Leu Glu  Ser Ala Trp Asn Val  Ala Lys Glu 
    1130                 1135                 1140             


Gly Thr  His Gly Ser His Val  Tyr Thr Lys Ala Leu  Leu Ala Tyr 
    1145                 1150                 1155             


Ala Phe  Ser Leu Leu Gly Lys  Gln Asn Gln Asn Arg  Glu Ile Leu 
    1160                 1165                 1170             


Asn Ser  Leu Asp Lys Glu Ala  Val Lys Glu Asp Asn  Leu Val His 
    1175                 1180                 1185             


Trp Glu  Arg Pro Gln Arg Pro  Lys Ala Pro Val Gly  His Leu Tyr 
    1190                 1195                 1200             


Gln Thr  Gln Ala Pro Ser Ala  Glu Val Glu Met Thr  Ser Tyr Val 
    1205                 1210                 1215             


Leu Leu  Ala Tyr Leu Thr Ala  Gln Pro Ala Pro Thr  Ser Gly Asp 
    1220                 1225                 1230             


Leu Thr  Ser Ala Thr Asn Ile  Val Lys Trp Ile Met  Lys Gln Gln 
    1235                 1240                 1245             


Asn Ala  Gln Gly Gly Phe Ser  Ser Thr Gln Asp Thr  Val Val Ala 
    1250                 1255                 1260             


Leu His  Ala Leu Ser Arg Tyr  Gly Ala Ala Thr Phe  Thr Arg Thr 
    1265                 1270                 1275             


Glu Lys  Thr Ala Gln Val Thr  Val Gln Asp Ser Gln  Thr Phe Ser 
    1280                 1285                 1290             


Thr Asn  Phe Gln Val Asp Asn  Asn Asn Leu Leu Leu  Leu Gln Gln 
    1295                 1300                 1305             


Ile Ser  Leu Pro Glu Leu Pro  Gly Glu Tyr Val Ile  Thr Val Thr 
    1310                 1315                 1320             


Gly Glu  Arg Cys Val Tyr Leu  Gln Thr Ser Met Lys  Tyr Asn Ile 
    1325                 1330                 1335             


Leu Pro  Glu Lys Glu Asp Ser  Pro Phe Ala Leu Lys  Val Gln Thr 
    1340                 1345                 1350             


Val Pro  Gln Thr Cys Asp Gly  His Lys Ala His Thr  Ser Phe Gln 
    1355                 1360                 1365             


Ile Ser  Leu Thr Ile Ser Tyr  Thr Gly Asn Arg Pro  Ala Ser Asn 
    1370                 1375                 1380             


Met Val  Ile Val Asp Val Lys  Met Val Ser Gly Phe  Ile Pro Leu 
    1385                 1390                 1395             


Lys Pro  Thr Val Lys Met Leu  Glu Arg Ser Ser Ser  Val Ser Arg 
    1400                 1405                 1410             


Thr Glu  Val Ser Asn Asn His  Val Leu Ile Tyr Val  Glu Gln Val 
    1415                 1420                 1425             


Thr Asn  Gln Thr Leu Ser Phe  Ser Phe Met Val Leu  Gln Asp Ile 
    1430                 1435                 1440             


Pro Val  Gly Asp Leu Lys Pro  Ala Ile Val Lys Val  Tyr Asp Tyr 
    1445                 1450                 1455             


Tyr Glu  Thr Asp Glu Ser Val  Val Ala Glu Tyr Ile  Ala Pro Cys 
    1460                 1465                 1470             


Ser Thr  Asp Thr Glu His Gly  Asn Val 
    1475                 1480         


<210>  34
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Leu Leu Trp Gly Leu Leu Val Leu Ser Trp Ser Cys Leu Gln 
1               5                   10                  15      


Gly Pro Cys Ser Val Phe Ser Pro Val Ser Ala Met Glu Pro Leu Gly 
            20                  25                  30          


Arg Gln Leu Thr Ser Gly Pro Asn Gln Glu Gln Val Ser Pro Leu Thr 
        35                  40                  45              


Leu Leu Lys Leu Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys 
    50                  55                  60                  


Ser Pro Pro Gly Val Cys Ser Arg Asp Pro Thr Pro Glu Gln Thr His 
65                  70                  75                  80  


Arg Leu Ala Arg Ala Met Met Ala Phe Thr Ala Asp Leu Phe Ser Leu 
                85                  90                  95      


Val Ala Gln Thr Ser Thr Cys Pro Asn Leu Ile Leu Ser Pro Leu Ser 
            100                 105                 110         


Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala Gln Asn His Thr 
        115                 120                 125             


Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly Ser Gly Pro Cys Leu 
    130                 135                 140                 


Pro His Leu Leu Ser Arg Leu Cys Gln Asp Leu Gly Pro Gly Ala Phe 
145                 150                 155                 160 


Arg Leu Ala Ala Arg Met Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu 
                165                 170                 175     


Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser 
            180                 185                 190         


Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val 
        195                 200                 205             


Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro 
    210                 215                 220                 


Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly Phe 
225                 230                 235                 240 


Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg Asp Ser Phe His 
                245                 250                 255     


Leu Asp Glu Gln Phe Thr Val Pro Val Glu Met Met Gln Ala Arg Thr 
            260                 265                 270         


Tyr Pro Leu Arg Trp Phe Leu Leu Glu Gln Pro Glu Ile Gln Val Ala 
        275                 280                 285             


His Phe Pro Phe Lys Asn Asn Met Ser Phe Val Val Leu Val Pro Thr 
    290                 295                 300                 


His Phe Glu Trp Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp 
305                 310                 315                 320 


Thr Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu 
                325                 330                 335     


Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser 
            340                 345                 350         


Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg Gly Ile 
        355                 360                 365             


Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His Gln Ser Thr Leu 
    370                 375                 380                 


Glu Leu Ser Glu Val Gly Val Glu Ala Ala Ala Ala Thr Ser Ile Ala 
385                 390                 395                 400 


Met Ser Arg Met Ser Leu Ser Ser Phe Ser Val Asn Arg Pro Phe Leu 
                405                 410                 415     


Phe Phe Ile Phe Glu Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser 
            420                 425                 430         


Val Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln 
        435                 440                 445             


Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro 
    450                 455                 460                 


Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met 
465                 470                 475                 480 


Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 
                485                 490     


<210>  35
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210>  36
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  37
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
                85                  90                  95      


Pro Ala Thr Gln 
            100 


<210>  38
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  39
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser 
1               5                   10                  15      


Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly Ala Asp Pro Gly Thr 
            20                  25                  30          


Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro Ala Ala Cys Val Cys Ser 
        35                  40                  45              


Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val Phe Cys Ser Ser Arg Asn 
    50                  55                  60                  


Leu Thr Arg Leu Pro Asp Gly Val Pro Gly Gly Thr Gln Ala Leu Trp 
65                  70                  75                  80  


Leu Asp Gly Asn Asn Leu Ser Ser Val Pro Pro Ala Ala Phe Gln Asn 
                85                  90                  95      


Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln Gly Gly Gln Leu Gly Ser 
            100                 105                 110         


Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu Asn Leu Cys His Leu His 
        115                 120                 125             


Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala Leu Gly Thr Phe Ala His 
    130                 135                 140                 


Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser Asn Asn Arg Leu Ser Arg 
145                 150                 155                 160 


Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly Ser Leu Trp Asp Leu Asn 
                165                 170                 175     


Leu Gly Trp Asn Ser Leu Ala Val Leu Pro Asp Ala Ala Phe Arg Gly 
            180                 185                 190         


Leu Gly Ser Leu Arg Glu Leu Val Leu Ala Gly Asn Arg Leu Ala Tyr 
        195                 200                 205             


Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala Glu Leu Arg Glu Leu Asp 
    210                 215                 220                 


Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys Ala Asn Val Phe Val Gln 
225                 230                 235                 240 


Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Ala Ala 
                245                 250                 255     


Val Ala Pro Gly Ala Phe Leu Gly Leu Lys Ala Leu Arg Trp Leu Asp 
            260                 265                 270         


Leu Ser His Asn Arg Val Ala Gly Leu Leu Glu Asp Thr Phe Pro Gly 
        275                 280                 285             


Leu Leu Gly Leu Arg Val Leu Arg Leu Ser His Asn Ala Ile Ala Ser 
    290                 295                 300                 


Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln 
305                 310                 315                 320 


Leu Gly His Asn Arg Ile Arg Gln Leu Ala Glu Arg Ser Phe Glu Gly 
                325                 330                 335     


Leu Gly Gln Leu Glu Val Leu Thr Leu Asp His Asn Gln Leu Gln Glu 
            340                 345                 350         


Val Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn 
        355                 360                 365             


Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro Glu Gln Val Phe Arg Gly 
    370                 375                 380                 


Leu Gly Lys Leu His Ser Leu His Leu Glu Gly Ser Cys Leu Gly Arg 
385                 390                 395                 400 


Ile Arg Pro His Thr Phe Thr Gly Leu Ser Gly Leu Arg Arg Leu Phe 
                405                 410                 415     


Leu Lys Asp Asn Gly Leu Val Gly Ile Glu Glu Gln Ser Leu Trp Gly 
            420                 425                 430         


Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr Ser Asn Gln Leu Thr His 
        435                 440                 445             


Leu Pro His Arg Leu Phe Gln Gly Leu Gly Lys Leu Glu Tyr Leu Leu 
    450                 455                 460                 


Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro Ala Asp Ala Leu Gly Pro 
465                 470                 475                 480 


Leu Gln Arg Ala Phe Trp Leu Asp Val Ser His Asn Arg Leu Glu Ala 
                485                 490                 495     


Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly Arg Leu Arg Tyr Leu Ser 
            500                 505                 510         


Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr Pro Gln Pro Pro Gly Leu 
        515                 520                 525             


Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp Asp Cys Gly Cys Pro Leu 
    530                 535                 540                 


Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg 
545                 550                 555                 560 


Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala Tyr 
                565                 570                 575     


Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly Leu 
            580                 585                 590         


Asp Leu Arg Asp Leu Ser Glu Ala His Phe Ala Pro Cys 
        595                 600                 605 


<210>  40
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  41
<211>  1744
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Ser Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  42
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  43
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Trp Val Trp Ala Leu Leu Leu Leu Ala Ala Leu Gly Ser Gly 
1               5                   10                  15      


Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
            20                  25                  30          


Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys 
        35                  40                  45              


Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser 
    50                  55                  60                  


Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
65                  70                  75                  80  


Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                85                  90                  95      


Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
            100                 105                 110         


Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp 
        115                 120                 125             


Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp 
    130                 135                 140                 


Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
145                 150                 155                 160 


Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu 
                165                 170                 175     


Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys 
            180                 185                 190         


Asp Gly Arg Ser Glu Arg Asn Leu Leu 
        195                 200     


<210>  44
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Pro Gly Ala Trp Leu Leu Trp Thr Ser Leu Leu Leu Leu Ala 
1               5                   10                  15      


Arg Pro Ala Gln Pro Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 
            20                  25                  30          


Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro 
        35                  40                  45              


Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu 
    50                  55                  60                  


Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe 
65                  70                  75                  80  


Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu 
                85                  90                  95      


Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 
            100                 105                 110         


Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 
        115                 120                 125             


Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 
    130                 135                 140                 


Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu 
145                 150                 155                 160 


Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu 
                165                 170                 175     


Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu 
            180                 185                 190         


Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu 
        195                 200                 205             


Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu 
    210                 215                 220                 


Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 
225                 230                 235                 240 


Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 
                245                 250                 255     


Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 
            260                 265                 270         


Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr 
        275                 280                 285             


Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val 
    290                 295                 300                 


Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu 
305                 310                 315                 320 


Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu 
                325                 330                 335     


Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu 
            340                 345                 350         


His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 
        355                 360                 365             


Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 
    370                 375                 380                 


Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp 
385                 390                 395                 400 


Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg 
                405                 410                 415     


Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly 
            420                 425                 430         


Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr 
        435                 440                 445             


Arg Asp His Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala 
    450                 455                 460                 


Gly Gly Ser Trp Asp Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln 
465                 470                 475                 480 


Cys Thr Tyr Ser Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln 
                485                 490                 495     


Ala Gln Cys Arg Trp Leu Asn Val Gln Leu Ser Pro Trp Gln Gly Ser 
            500                 505                 510         


Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser 
        515                 520                 525             


Cys Gly Ser Leu Arg Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly 
    530                 535                 540                 


Pro 
545 


<210>  45
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 
            180                 185                 190         


Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 
    210                 215                 220                 


Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 
                245                 250                 255     


Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 
        275                 280                 285             


Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Asp Val Lys Pro Cys 
            340                 345 


<210>  46
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     


<210>  47
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  48
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 
1               5                   10                  15      


Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln 
            20                  25                  30          


Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala 
        35                  40                  45              


Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr 
    50                  55                  60                  


Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser 
65                  70                  75                  80  


Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly 
                85                  90                  95      


Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser 
            100                 105                 110         


Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp 
        115                 120                 125             


Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro 
    130                 135                 140                 


Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr 
145                 150                 155                 160 


Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu 
                165                 170                 175     


Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu 
            180                 185                 190         


Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val 
    210                 215                 220                 


Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys 
225                 230                 235                 240 


Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys 
                245                 250                 255     


Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val 
            260                 265                 270         


Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn 
        275                 280                 285             


Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala 
    290                 295                 300                 


Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys 
305                 310                 315                 320 


Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr 
                325                 330                 335     


Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn 
            340                 345                 350         


<210>  49
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Val Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asn Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Asn Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Pro Val Ser Leu Val Asp Gly Trp Leu Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Ser Val Trp Gly Gln Gly Thr Leu 
        115                 120 


<210>  50
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Asp Pro Lys Tyr Ala Asp Leu Pro Gly Ile Ala Arg Asn Glu 
1               5                   10                  15      


Pro Asp Val Tyr Glu Thr Ser Asp Leu Pro Glu Asp Asp Gln Ala Glu 
            20                  25                  30          


Phe Asp Ala Glu Glu Leu Thr Ser Thr Ser Val Glu His Ile Ile Val 
        35                  40                  45              


Asn Pro Asn Ala Ala Tyr Asp Lys Phe Lys Asp Lys Arg Val Gly Thr 
    50                  55                  60                  


Lys Gly Leu Asp Phe Ser Asp Arg Ile Gly Lys Thr Lys Arg Thr Gly 
65                  70                  75                  80  


Tyr Glu Ser Gly Glu Tyr Glu Met Leu Gly Glu Gly Leu Gly Val Lys 
                85                  90                  95      


Glu Thr Pro Gln Gln Lys Tyr Gln Arg Leu Leu His Glu Val Gln Glu 
            100                 105                 110         


Leu Thr Thr Glu Val Glu Lys Ile Lys Thr Thr Val Lys Glu Ser Ala 
        115                 120                 125             


Thr Glu Glu Lys Leu Thr Pro Val Leu Leu Ala Lys Gln Leu Ala Ala 
    130                 135                 140                 


Leu Lys Gln Gln Leu Val Ala Ser His Leu Glu Lys Leu Leu Gly Pro 
145                 150                 155                 160 


Asp Ala Ala Ile Asn Leu Thr Asp Pro Asp Gly Ala Leu Ala Lys Arg 
                165                 170                 175     


Leu Leu Leu Gln Leu Glu Ala Thr Lys Asn Ser Lys Gly Gly Ser Gly 
            180                 185                 190         


Gly Lys Thr Thr Gly Thr Pro Pro Asp Ser Ser Leu Val Thr Tyr Glu 
        195                 200                 205             


Leu His Ser Arg Pro Glu Gln Asp Lys Phe Ser Gln Ala Ala Lys Val 
    210                 215                 220                 


Ala Glu Leu Glu Lys Arg Leu Thr Glu Leu Glu Thr Ala Val Arg Cys 
225                 230                 235                 240 


Asp Gln Asp Ala Gln Asn Pro Leu Ser Ala Gly Leu Gln Gly Ala Cys 
                245                 250                 255     


Leu Met Glu Thr Val Glu Leu Leu Gln Ala Lys Val Ser Ala Leu Asp 
            260                 265                 270         


Leu Ala Val Leu Asp Gln Val Glu Ala Arg Leu Gln Ser Val Leu Gly 
        275                 280                 285             


Lys Val Asn Glu Ile Ala Lys His Lys Ala Ser Val Glu Asp Ala Asp 
    290                 295                 300                 


Thr Gln Ser Lys Val His Gln Leu Tyr Glu Thr Ile Gln Arg Trp Ser 
305                 310                 315                 320 


Pro Ile Ala Ser Thr Leu Pro Glu Leu Val Gln Arg Leu Val Thr Ile 
                325                 330                 335     


Lys Gln Leu His Glu Gln Ala Met Gln Phe Gly Gln Leu Leu Thr His 
            340                 345                 350         


Leu Asp Thr Thr Gln Gln Met Ile Ala Asn Ser Leu Lys Asp Asn Thr 
        355                 360                 365             


Thr Leu Leu Thr Gln Val Gln Thr Thr Met Arg Glu Asn Leu Ala Thr 
    370                 375                 380                 


Val Glu Gly Asn Phe Ala Ser Ile Asp Glu Arg Met Lys Lys Leu Gly 
385                 390                 395                 400 


Lys 
    


<210>  51
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 
1               5                   10                  15      


Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 
            20                  25                  30          


Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 
        35                  40                  45              


Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 
    50                  55                  60                  


Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 
65                  70                  75                  80  


Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 
                85                  90                  95      


Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 
            100                 105                 110         


Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 
        115                 120                 125             


Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 
    130                 135                 140                 


Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 
145                 150                 155                 160 


Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 
                165                 170                 175     


Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 
            180                 185                 190         


Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln 
        195                 200                 205             


Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser 
    210                 215                 220                 


Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln 
225                 230                 235                 240 


Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe 
                245                 250                 255     


Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val 
            260                 265                 270         


Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 
        275                 280                 285             


Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
    290                 295                 300                 


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
305                 310                 315                 320 


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
            340                 345                 350         


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
        355                 360                 365             


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
    370                 375                 380                 


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
385                 390                 395                 400 


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
                405                 410                 415     


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
            420                 425                 430         


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
        435                 440                 445             


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
    450                 455                 460                 


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
465                 470                 475                 480 


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
                485                 490                 495     


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
            500                 505                 510         


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
        515                 520                 525             


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
    530                 535                 540                 


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
545                 550                 555                 560 


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
                565                 570                 575     


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
            580                 585                 590         


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
        595                 600                 605             


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
    610                 615                 620                 


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
625                 630                 635                 640 


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
                645                 650                 655     


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
            660                 665                 670         


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
        675                 680                 685             


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
    690                 695                 700                 


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
705                 710                 715                 720 


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
                725                 730                 735     


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
            740                 745                 750         


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
        755                 760                 765             


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
    770                 775                 780                 


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
785                 790                 795                 800 


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
                805                 810                 815     


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
            820                 825                 830         


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
        835                 840                 845             


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
    850                 855                 860                 


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
865                 870                 875                 880 


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
                885                 890                 895     


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
            900                 905                 910     


<210>  52
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 
145                 150                 155                 160 


Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 
                165                 170                 175     


Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln 
            180                 185                 190         


Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr 
        195                 200                 205             


Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe 
    210                 215                 220                 


Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser 
225                 230                 235                 240 


Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 
                245                 250                 255     


Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 
            260                 265                 270         


Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu 
        275                 280                 285             


Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val 
    290                 295                 300                 


Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile 
305                 310                 315                 320 


Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly 
                325                 330                 335     


Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn 
            340                 345                 350         


Gln Met Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg 
        355                 360                 365             


His Ala Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser 
    370                 375                 380                 


Pro Lys Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln 
385                 390                 395                 400 


Lys Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu 
                405                 410                 415     


Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly 
            420                 425                 430         


Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val 
        435                 440                 445             


Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly 
    450                 455                 460                 


Val Gly Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp 
465                 470                 475                 480 


His Val Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu 
                485                 490                 495     


Ile Ser Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly 
            500                 505                 510         


Asn Asp His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln 
        515                 520                 525             


Trp Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe 
    530                 535                 540                 


Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp 
545                 550                 555                 560 


Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His 
                565                 570                 575     


Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu 
            580                 585                 590         


Arg Arg Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu 
        595                 600                 605             


Asn Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys 
    610                 615                 620                 


Leu Asn Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu 
625                 630                 635                 640 


Val Val Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg 
                645                 650                 655     


Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu 
            660                 665                 670         


Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg 
        675                 680                 685             


Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro 
    690                 695                 700                 


Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser 
705                 710                 715                 720 


Lys Val Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln 
                725                 730                 735     


Pro Trp Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
            740                 745                 750         


<210>  53
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu 
1               5                   10                  15      


Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg 
            20                  25                  30          


Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro 
        35                  40                  45              


Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg 
    50                  55                  60                  


Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu 
65                  70                  75                  80  


Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 
                85                  90                  95      


His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 
            100                 105                 110         


Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 
        115                 120                 125             


Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 
    130                 135                 140                 


Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly 
145                 150                 155                 160 


Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu 
                165                 170                 175     


Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr 
            180                 185                 190         


Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn 
        195                 200                 205             


Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val 
    210                 215                 220             


<210>  54
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                165                 170                 175     


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
            180                 185                 190         


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
        195                 200                 205             


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
    210                 215                 220                 


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
225                 230                 235                 240 


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                245                 250                 255     


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
            260                 265                 270         


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
        275                 280                 285             


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
    290                 295                 300                 


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
305                 310                 315                 320 


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                325                 330                 335     


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
            340                 345                 350         


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
        355                 360                 365             


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
    370                 375                 380                 


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
385                 390                 395                 400 


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                405                 410                 415     


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
            420                 425                 430         


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
        435                 440                 445             


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
    450                 455                 460                 


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
465                 470                 475                 480 


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                485                 490                 495     


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
            500                 505                 510         


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
        515                 520                 525             


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
    530                 535                 540                 


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
545                 550                 555                 560 


Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
                565                 570                 575     


Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 
            580                 585                 590         


Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 
        595                 600                 605             


Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 
    610                 615                 620                 


Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 
625                 630                 635                 640 


Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 
                645                 650                 655     


Ser Pro Gln Asn Cys Ser Ile Met 
            660                 


<210>  55
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      


Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          


Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              


Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  


Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  


His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      


Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         


Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             


Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 


Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 


Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn 
                165                 170                 175     


Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile 
            180                 185                 190         


Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val 
        195                 200                 205             


Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala 
    210                 215                 220                 


Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val 
225                 230                 235                 240 


Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe 
                245                 250                 255     


Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn Gly 
            260                 265                 270         


Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly 
        275                 280                 285             


Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe 
    290                 295                 300                 


His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile 
305                 310                 315                 320 


Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro 
                325                 330                 335     


Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr 
            340                 345                 350         


Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro 
        355                 360                 365             


Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala 
    370                 375                 380                 


Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val 
385                 390                 395                 400 


Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val 
                405                 410                 415     


Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp 
            420                 425                 430         


Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly 
        435                 440                 445             


Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val 
    450                 455                 460                 


Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr 
465                 470                 475                 480 


Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met 
                485                 490                 495     


Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn 
            500                 505                 510         


Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro 
        515                 520                 525             


Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys 
    530                 535                 540                 


Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu 
545                 550                 555                 560 


Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp 
                565                 570                 575     


Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg 
            580                 585                 590         


Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu 
        595                 600                 605             


Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val 
    610                 615                 620                 


Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly 
625                 630                 635                 640 


Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val 
                645                 650                 655     


Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr 
            660                 665                 670         


Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln 
        675                 680                 685             


Gly Gly Ala Thr Arg Met Tyr Ala Leu Thr Ser Asp Ala Gln Pro Leu 
    690                 695                 700                 


Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly 
705                 710                 715                 720 


Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile 
                725                 730                 735     


Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly 
            740                 745                 750         


Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu 
        755                 760                 765             


Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu 
    770                 775                 780                 


Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe 
785                 790                 795                 800 


Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val 
                805                 810                 815     


Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu 
            820                 825                 830         


His Val Tyr Ser Leu Gly Ser Asp 
        835                 840 


<210>  56
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Gln Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asp Gln Cys Ile Tyr Asn Thr Thr Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Ile Ser Arg Tyr Val Gly Gly 
            100                 105                 110         


Gln Glu His Phe Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr 
        115                 120                 125             


Met Leu Ala Phe Asp Val Asn Asp Glu Lys Asn Trp Gly Leu Ser Val 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Arg Ile Pro Lys Ser Asp Val Val Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  57
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  58
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  59
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala 
1               5                   10                  15      


Ser Gly Ser Pro Gly Pro Gly Glu Gly Ser Ala Gly Gly Glu Lys Arg 
            20                  25                  30          


Ser Thr Ala Pro Ser Ala Ala Ala Ser Ala Ser Ala Ser Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Ala Gly Gly Gly Ala Glu Ala Leu Glu Leu Leu Glu His 
    50                  55                  60                  


Cys Gly Val Cys Arg Glu Arg Leu Arg Pro Glu Arg Glu Pro Arg Leu 
65                  70                  75                  80  


Leu Pro Cys Leu His Ser Ala Cys Ser Ala Cys Leu Gly Pro Ala Ala 
                85                  90                  95      


Pro Ala Ala Ala Asn Ser Ser Gly Asp Gly Gly Ala Ala Gly Asp Gly 
            100                 105                 110         


Thr Val Val Asp Cys Pro Val Cys Lys Gln Gln Cys Phe Ser Lys Asp 
        115                 120                 125             


Ile Val Glu Asn Tyr Phe Met Arg Asp Ser Gly Ser Lys Ala Ala Thr 
    130                 135                 140                 


Asp Ala Gln Asp Ala Asn Gln Cys Cys Thr Ser Cys Glu Asp Asn Ala 
145                 150                 155                 160 


Pro Ala Thr Ser Tyr Cys Val Glu Cys Ser Glu Pro Leu Cys Glu Thr 
                165                 170                 175     


Cys Val Glu Ala His Gln Arg Val Lys Tyr Thr Lys Asp His Thr Val 
            180                 185                 190         


Arg Ser Thr Gly Pro Ala Lys Ser Arg Asp Gly Glu Arg Thr Val Tyr 
        195                 200                 205             


Cys Asn Val His Lys His Glu Pro Leu Val Leu Phe Cys Glu Ser Cys 
    210                 215                 220                 


Asp Thr Leu Thr Cys Arg Asp Cys Gln Leu Asn Ala His Lys Asp His 
225                 230                 235                 240 


Gln Tyr Gln Phe Leu Glu Asp Ala Val Arg Asn Gln Arg Lys Leu Leu 
                245                 250                 255     


Ala Ser Leu Val Lys Arg Leu Gly Asp Lys His Ala Thr Leu Gln Lys 
            260                 265                 270         


Ser Thr Lys Glu Val Arg Ser Ser Ile Arg Gln Val Ser Asp Val Gln 
        275                 280                 285             


Lys Arg Val Gln Val Asp Val Lys Met Ala Ile Leu Gln Ile Met Lys 
    290                 295                 300                 


Glu Leu Asn Lys Arg Gly Arg Val Leu Val Asn Asp Ala Gln Lys Val 
305                 310                 315                 320 


Thr Glu Gly Gln Gln Glu Arg Leu Glu Arg Gln His Trp Thr Met Thr 
                325                 330                 335     


Lys Ile Gln Lys His Gln Glu His Ile Leu Arg Phe Ala Ser Trp Ala 
            340                 345                 350         


Leu Glu Ser Asp Asn Asn Thr Ala Leu Leu Leu Ser Lys Lys Leu Ile 
        355                 360                 365             


Tyr Phe Gln Leu His Arg Ala Leu Lys Met Ile Val Asp Pro Val Glu 
    370                 375                 380                 


Pro His Gly Glu Met Lys Phe Gln Trp Asp Leu Asn Ala Trp Thr Lys 
385                 390                 395                 400 


Ser Ala Glu Ala Phe Gly Lys Ile Val Ala Glu Arg Pro Gly Thr Asn 
                405                 410                 415     


Ser Thr Gly Pro Ala Pro Met Ala Pro Pro Arg Ala Pro Gly Pro Leu 
            420                 425                 430         


Ser Lys Gln Gly Ser Gly Ser Ser Gln Pro Met Glu Val Gln Glu Gly 
        435                 440                 445             


Tyr Gly Phe Gly Ser Gly Asp Asp Pro Tyr Ser Ser Ala Glu Pro His 
    450                 455                 460                 


Val Ser Gly Val Lys Arg Ser Arg Ser Gly Glu Gly Glu Val Ser Gly 
465                 470                 475                 480 


Leu Met Arg Lys Val Pro Arg Val Ser Leu Glu Arg Leu Asp Leu Asp 
                485                 490                 495     


Leu Thr Ala Asp Ser Gln Pro Pro Val Phe Lys Val Phe Pro Gly Ser 
            500                 505                 510         


Thr Thr Glu Asp Tyr Asn Leu Ile Val Ile Glu Arg Gly Ala Ala Ala 
        515                 520                 525             


Ala Ala Thr Gly Gln Pro Gly Thr Ala Pro Ala Gly Thr Pro Gly Ala 
    530                 535                 540                 


Pro Pro Leu Ala Gly Met Ala Ile Val Lys Glu Glu Glu Thr Glu Ala 
545                 550                 555                 560 


Ala Ile Gly Ala Pro Pro Thr Ala Thr Glu Gly Pro Glu Thr Lys Pro 
                565                 570                 575     


Val Leu Met Ala Leu Ala Glu Gly Pro Gly Ala Glu Gly Pro Arg Leu 
            580                 585                 590         


Ala Ser Pro Ser Gly Ser Thr Ser Ser Gly Leu Glu Val Val Ala Pro 
        595                 600                 605             


Glu Gly Thr Ser Ala Pro Gly Gly Gly Pro Gly Thr Leu Asp Asp Ser 
    610                 615                 620                 


Ala Thr Ile Cys Arg Val Cys Gln Lys Pro Gly Asp Leu Val Met Cys 
625                 630                 635                 640 


Asn Gln Cys Glu Phe Cys Phe His Leu Asp Cys His Leu Pro Ala Leu 
                645                 650                 655     


Gln Asp Val Pro Gly Glu Glu Trp Ser Cys Ser Leu Cys His Val Leu 
            660                 665                 670         


Pro Asp Leu Lys Glu Glu Asp Gly Ser Leu Ser Leu Asp Gly Ala Asp 
        675                 680                 685             


Ser Thr Gly Val Val Ala Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys 
    690                 695                 700                 


Glu Arg Val Leu Leu Ala Leu Phe Cys His Glu Pro Cys Arg Pro Leu 
705                 710                 715                 720 


His Gln Leu Ala Thr Asp Ser Thr Phe Ser Leu Asp Gln Pro Gly Gly 
                725                 730                 735     


Thr Leu Asp Leu Thr Leu Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser 
            740                 745                 750         


Pro Pro Tyr Ser Ser Pro Gln Glu Phe Ala Gln Asp Val Gly Arg Met 
        755                 760                 765             


Phe Lys Gln Phe Asn Lys Leu Thr Glu Asp Lys Ala Asp Val Gln Ser 
    770                 775                 780                 


Ile Ile Gly Leu Gln Arg Phe Phe Glu Thr Arg Met Asn Glu Ala Phe 
785                 790                 795                 800 


Gly Asp Thr Lys Phe Ser Ala Val Leu Val Glu Pro Pro Pro Met Ser 
                805                 810                 815     


Leu Pro Gly Ala Gly Leu Ser Ser Gln Glu Leu Ser Gly Gly Pro Gly 
            820                 825                 830         


Asp Gly Pro 
        835 


<210>  60
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln 
1               5                   10                  15      


Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser 
            20                  25                  30          


Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser 
        35                  40                  45              


Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly 
    50                  55                  60                  


Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu 
65                  70                  75                  80  


Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu 
                85                  90                  95      


Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu 
            100                 105                 110         


Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu 
        115                 120                 125             


Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr 
    130                 135                 140                 


Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu 
145                 150                 155                 160 


His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu 
                165                 170                 175     


Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr 
            180                 185                 190         


Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu 
        195                 200                 205             


Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu 
    210                 215                 220                 


Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr 
225                 230                 235                 240 


Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe 
                245                 250                 255     


Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu 
            260                 265                 270         


Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp 
        275                 280                 285             


Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp 
    290                 295                 300                 


Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys 
305                 310                 315                 320 


Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys 
                325                 330                 335     


Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln 
            340                 345         


<210>  61
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 
            20                  25                  30          


Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 
        35                  40                  45              


Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 
    50                  55                  60                  


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
65                  70                  75                  80  


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
                85                  90                  95      


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 
            100                 105                 110         


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 
        115                 120                 125             


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 
    130                 135                 140                 


Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 
145                 150                 155                 160 


Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 
                165                 170                 175     


Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
            180                 185                 190         


Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 
        195                 200                 205             


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
    210                 215                 220                 


Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
225                 230                 235                 240 


Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 
                245                 250                 255     


Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 
            260                 265                 270         


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 
        275                 280                 285             


Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
    290                 295                 300                 


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 
305                 310                 315                 320 


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 
                325                 330                 335     


Leu Asn 
        


<210>  62
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Ser Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  63
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  64
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  65
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  65

Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu Val Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser His Gly Gln Leu His Val Glu His Asp Gly Glu Ser Cys Ser 
            20                  25                  30          


Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly Glu Gly Ser Pro Ser 
        35                  40                  45              


Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala Phe Arg Phe Tyr Tyr 
    50                  55                  60                  


Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile Phe Phe Ser Pro Leu 
65                  70                  75                  80  


Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu Gly Ala Cys Ser His 
                85                  90                  95      


Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr Glu Leu 
            100                 105                 110         


Ser Glu Ser Asp Val His Arg Gly Phe Gln His Leu Leu His Thr Leu 
        115                 120                 125             


Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val Gly Ser Ala Leu Phe 
    130                 135                 140                 


Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe Leu Asn Asp Thr Met 
145                 150                 155                 160 


Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn Phe Tyr Asp Thr Val 
                165                 170                 175     


Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys Lys Glu Thr Arg Gly 
            180                 185                 190         


Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys Asp Val Leu Met Val 
        195                 200                 205             


Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp Glu Lys Pro Phe Ile 
    210                 215                 220                 


Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val Asp Glu Asn Thr Thr 
225                 230                 235                 240 


Val Arg Val Pro Met Met Leu Gln Asp Gln Glu His His Trp Tyr Leu 
                245                 250                 255     


His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg Met Asp Tyr Lys Gly 
            260                 265                 270         


Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln Gly Lys Met Arg Glu 
        275                 280                 285             


Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met Arg Trp Asn Asn Leu 
    290                 295                 300                 


Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu Leu His Leu Pro Lys 
305                 310                 315                 320 


Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln Ile Leu Pro Arg Leu 
                325                 330                 335     


Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp Leu Ser Gly Ile Thr 
            340                 345                 350         


Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe His Lys Ala Thr Leu 
        355                 360                 365             


Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala Ala Thr Ser Phe Ala 
    370                 375                 380                 


Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn 
385                 390                 395                 400 


Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln Ser Val Leu 
                405                 410                 415     


Phe Leu Gly Lys 
            420 


<210>  66
<211>  1946
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Val Glu Ser Cys Leu Leu Thr Phe Arg Ala Phe Phe Trp Trp Ile 
1               5                   10                  15      


Ala Leu Ile Lys Met Asp Leu Ser Asp Leu Gly Glu Ala Ala Ala Phe 
            20                  25                  30          


Leu Arg Arg Ser Glu Ala Glu Leu Leu Leu Leu Gln Ala Thr Ala Leu 
        35                  40                  45              


Asp Gly Lys Lys Lys Cys Trp Ile Pro Asp Gly Glu Asn Ala Tyr Ile 
    50                  55                  60                  


Glu Ala Glu Val Lys Gly Ser Glu Asp Asp Gly Thr Val Ile Val Glu 
65                  70                  75                  80  


Thr Ala Asp Gly Glu Ser Leu Ser Ile Lys Glu Asp Lys Ile Gln Gln 
                85                  90                  95      


Met Asn Pro Pro Glu Phe Glu Met Ile Glu Asp Met Ala Met Leu Thr 
            100                 105                 110         


His Leu Asn Glu Ala Ser Val Leu His Thr Leu Lys Arg Arg Tyr Gly 
        115                 120                 125             


Gln Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Ile Asn 
    130                 135                 140                 


Pro Tyr Lys Trp Leu Pro Val Tyr Gln Lys Glu Val Met Ala Ala Tyr 
145                 150                 155                 160 


Lys Gly Lys Arg Arg Ser Glu Ala Pro Pro His Ile Phe Ala Val Ala 
                165                 170                 175     


Asn Asn Ala Phe Gln Asp Met Leu His Asn Arg Glu Asn Gln Ser Ile 
            180                 185                 190         


Leu Phe Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Ser Lys His 
        195                 200                 205             


Ile Ile Gln Tyr Phe Ala Thr Ile Ala Ala Met Ile Glu Ser Arg Lys 
    210                 215                 220                 


Lys Gln Gly Ala Leu Glu Asp Gln Ile Met Gln Ala Asn Thr Ile Leu 
225                 230                 235                 240 


Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser Ser Arg 
                245                 250                 255     


Phe Gly Lys Phe Ile Arg Met His Phe Gly Ala Arg Gly Met Leu Ser 
            260                 265                 270         


Ser Val Asp Ile Asp Ile Tyr Leu Leu Glu Lys Ser Arg Val Ile Phe 
        275                 280                 285             


Gln Gln Ala Gly Glu Arg Asn Tyr His Ile Phe Tyr Gln Ile Leu Ser 
    290                 295                 300                 


Gly Gln Lys Glu Leu His Asp Leu Leu Leu Val Ser Ala Asn Pro Ser 
305                 310                 315                 320 


Asp Phe His Phe Cys Ser Cys Gly Ala Val Thr Val Glu Ser Leu Asp 
                325                 330                 335     


Asp Ala Glu Glu Leu Leu Ala Thr Glu Gln Ala Met Asp Ile Leu Gly 
            340                 345                 350         


Phe Leu Pro Asp Glu Lys Tyr Gly Cys Tyr Lys Leu Thr Gly Ala Ile 
        355                 360                 365             


Met His Phe Gly Asn Met Lys Phe Lys Gln Lys Pro Arg Glu Glu Gln 
    370                 375                 380                 


Leu Glu Ala Asp Gly Thr Glu Asn Ala Asp Lys Ala Ala Phe Leu Met 
385                 390                 395                 400 


Gly Ile Asn Ser Ser Glu Leu Val Lys Cys Leu Ile His Pro Arg Ile 
                405                 410                 415     


Lys Val Gly Asn Glu Tyr Val Thr Arg Gly Gln Thr Ile Glu Gln Val 
            420                 425                 430         


Thr Cys Ala Val Gly Ala Leu Ser Lys Ser Met Tyr Glu Arg Met Phe 
        435                 440                 445             


Lys Trp Leu Val Ala Arg Ile Asn Arg Ala Leu Asp Ala Lys Leu Ser 
    450                 455                 460                 


Arg Gln Phe Phe Ile Gly Ile Leu Asp Ile Thr Gly Phe Glu Ile Leu 
465                 470                 475                 480 


Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn Phe Thr Asn Glu Lys 
                485                 490                 495     


Leu Gln Gln Phe Phe Asn Trp His Met Phe Val Leu Glu Gln Glu Glu 
            500                 505                 510         


Tyr Lys Lys Glu Ser Ile Glu Trp Val Ser Ile Gly Phe Gly Leu Asp 
        515                 520                 525             


Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met Gly Ile Leu Ser 
    530                 535                 540                 


Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr Asp Leu Thr Phe 
545                 550                 555                 560 


Lys Thr Lys Leu Phe Asp Asn His Phe Gly Lys Ser Val His Leu Gln 
                565                 570                 575     


Lys Pro Lys Pro Asp Lys Lys Lys Phe Glu Ala His Phe Glu Leu Val 
            580                 585                 590         


His Tyr Ala Gly Val Val Pro Tyr Asn Ile Ser Gly Trp Leu Glu Lys 
        595                 600                 605             


Asn Lys Asp Leu Leu Asn Glu Thr Val Val Ala Val Phe Gln Lys Ser 
    610                 615                 620                 


Ser Asn Arg Leu Leu Ala Ser Leu Phe Glu Asn Tyr Met Ser Thr Asp 
625                 630                 635                 640 


Ser Ala Ile Pro Phe Gly Glu Lys Lys Arg Lys Lys Gly Ala Ser Phe 
                645                 650                 655     


Gln Thr Val Ala Ser Leu His Lys Glu Asn Leu Asn Lys Leu Met Thr 
            660                 665                 670         


Asn Leu Lys Ser Thr Ala Pro His Phe Val Arg Cys Ile Asn Pro Asn 
        675                 680                 685             


Val Asn Lys Ile Pro Gly Ile Leu Asp Pro Tyr Leu Val Leu Gln Gln 
    690                 695                 700                 


Leu Arg Cys Asn Gly Val Leu Glu Gly Thr Arg Ile Cys Arg Glu Gly 
705                 710                 715                 720 


Phe Pro Asn Arg Leu Gln Tyr Ala Asp Phe Lys Gln Arg Tyr Cys Ile 
                725                 730                 735     


Leu Asn Pro Arg Thr Phe Pro Lys Ser Lys Phe Val Ser Ser Arg Lys 
            740                 745                 750         


Ala Ala Glu Glu Leu Leu Gly Ser Leu Glu Ile Asp His Thr Gln Tyr 
        755                 760                 765             


Arg Phe Gly Ile Thr Lys Val Phe Phe Lys Ala Gly Phe Leu Gly Gln 
    770                 775                 780                 


Leu Glu Ala Ile Arg Asp Glu Arg Leu Ser Lys Val Phe Thr Leu Phe 
785                 790                 795                 800 


Gln Ala Arg Ala Gln Gly Lys Leu Met Arg Ile Lys Phe Gln Lys Ile 
                805                 810                 815     


Leu Glu Glu Arg Asp Ala Leu Ile Leu Ile Gln Trp Asn Ile Arg Ala 
            820                 825                 830         


Phe Met Ala Val Lys Asn Trp Pro Trp Met Arg Leu Phe Phe Lys Ile 
        835                 840                 845             


Lys Pro Leu Val Lys Ser Ser Glu Val Gly Glu Glu Val Ala Gly Leu 
    850                 855                 860                 


Lys Glu Glu Cys Ala Gln Leu Gln Lys Ala Leu Glu Lys Ser Glu Phe 
865                 870                 875                 880 


Gln Arg Glu Glu Leu Lys Ala Lys Gln Val Ser Leu Thr Gln Glu Lys 
                885                 890                 895     


Asn Asp Leu Ile Leu Gln Leu Gln Ala Glu Gln Glu Thr Leu Ala Asn 
            900                 905                 910         


Val Glu Glu Gln Cys Glu Trp Leu Ile Lys Ser Lys Ile Gln Leu Glu 
        915                 920                 925             


Ala Arg Val Lys Glu Leu Ser Glu Arg Val Glu Glu Glu Glu Glu Ile 
    930                 935                 940                 


Asn Ser Glu Leu Thr Ala Arg Gly Arg Lys Leu Glu Asp Glu Cys Phe 
945                 950                 955                 960 


Glu Leu Lys Lys Glu Ile Asp Asp Leu Glu Thr Met Leu Val Lys Ser 
                965                 970                 975     


Glu Lys Glu Lys Arg Thr Thr Glu His Lys Val Lys Asn Leu Thr Glu 
            980                 985                 990         


Glu Val Glu Phe Leu Asn Glu Asp  Ile Ser Lys Leu Asn  Arg Ala Ala 
        995                 1000                 1005             


Lys Val  Val Gln Glu Ala His  Gln Gln Thr Leu Asp  Asp Leu His 
    1010                 1015                 1020             


Met Glu  Glu Glu Lys Leu Ser  Ser Leu Ser Lys Ala  Asn Leu Lys 
    1025                 1030                 1035             


Leu Glu  Gln Gln Val Asp Glu  Leu Glu Gly Ala Leu  Glu Gln Glu 
    1040                 1045                 1050             


Arg Lys  Ala Arg Met Asn Cys  Glu Arg Glu Leu His  Lys Leu Glu 
    1055                 1060                 1065             


Gly Asn  Leu Lys Leu Asn Arg  Glu Ser Met Glu Asn  Leu Glu Ser 
    1070                 1075                 1080             


Ser Gln  Arg His Leu Ala Glu  Glu Leu Arg Lys Lys  Glu Leu Glu 
    1085                 1090                 1095             


Leu Ser  Gln Met Asn Ser Lys  Val Glu Asn Glu Lys  Gly Leu Val 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Thr Val  Lys Glu Leu Gln Thr  Gln Ile Lys 
    1115                 1120                 1125             


Asp Leu  Lys Glu Lys Leu Glu  Ala Glu Arg Thr Thr  Arg Ala Lys 
    1130                 1135                 1140             


Met Glu  Arg Glu Arg Ala Asp  Leu Thr Gln Asp Leu  Ala Asp Leu 
    1145                 1150                 1155             


Asn Glu  Arg Leu Glu Glu Val  Gly Gly Ser Ser Leu  Ala Gln Leu 
    1160                 1165                 1170             


Glu Ile  Thr Lys Lys Gln Glu  Thr Lys Phe Gln Lys  Leu His Arg 
    1175                 1180                 1185             


Asp Met  Glu Glu Ala Thr Leu  His Phe Glu Thr Thr  Ser Ala Ser 
    1190                 1195                 1200             


Leu Lys  Lys Arg His Ala Asp  Ser Leu Ala Glu Leu  Glu Gly Gln 
    1205                 1210                 1215             


Val Glu  Asn Leu Gln Gln Val  Lys Gln Lys Leu Glu  Lys Asp Lys 
    1220                 1225                 1230             


Ser Asp  Leu Gln Leu Glu Val  Asp Asp Leu Leu Thr  Arg Val Glu 
    1235                 1240                 1245             


Gln Met  Thr Arg Ala Lys Ala  Asn Ala Glu Lys Leu  Cys Thr Leu 
    1250                 1255                 1260             


Tyr Glu  Glu Arg Leu His Glu  Ala Thr Ala Lys Leu  Asp Lys Val 
    1265                 1270                 1275             


Thr Gln  Leu Ala Asn Asp Leu  Ala Ala Gln Lys Thr  Lys Leu Trp 
    1280                 1285                 1290             


Ser Glu  Ser Gly Glu Phe Leu  Arg Arg Leu Glu Glu  Lys Glu Ala 
    1295                 1300                 1305             


Leu Ile  Asn Gln Leu Ser Arg  Glu Lys Ser Asn Phe  Thr Arg Gln 
    1310                 1315                 1320             


Ile Glu  Asp Leu Arg Gly Gln  Leu Glu Lys Glu Thr  Lys Ser Gln 
    1325                 1330                 1335             


Ser Ala  Leu Ala His Ala Leu  Gln Lys Ala Gln Arg  Asp Cys Asp 
    1340                 1345                 1350             


Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Gln Glu Val  Lys Ala Glu 
    1355                 1360                 1365             


Leu His  Arg Thr Leu Ser Lys  Val Asn Ala Glu Met  Val Gln Trp 
    1370                 1375                 1380             


Arg Met  Lys Tyr Glu Asn Asn  Val Ile Gln Arg Thr  Glu Asp Leu 
    1385                 1390                 1395             


Glu Asp  Ala Lys Lys Glu Leu  Ala Ile Arg Leu Gln  Glu Ala Ala 
    1400                 1405                 1410             


Glu Ala  Met Gly Val Ala Asn  Ala Arg Asn Ala Ser  Leu Glu Arg 
    1415                 1420                 1425             


Ala Arg  His Gln Leu Gln Leu  Glu Leu Gly Asp Ala  Leu Ser Asp 
    1430                 1435                 1440             


Leu Gly  Lys Val Arg Ser Ala  Ala Ala Arg Leu Asp  Gln Lys Gln 
    1445                 1450                 1455             


Leu Gln  Ser Gly Lys Ala Leu  Ala Asp Trp Lys Gln  Lys His Glu 
    1460                 1465                 1470             


Glu Ser  Gln Ala Leu Leu Asp  Ala Ser Gln Lys Glu  Val Gln Ala 
    1475                 1480                 1485             


Leu Ser  Thr Glu Leu Leu Lys  Leu Lys Asn Thr Tyr  Glu Glu Ser 
    1490                 1495                 1500             


Ile Val  Gly Gln Glu Thr Leu  Arg Arg Glu Asn Lys  Asn Leu Gln 
    1505                 1510                 1515             


Glu Glu  Ile Ser Asn Leu Thr  Asn Gln Val Arg Glu  Gly Thr Lys 
    1520                 1525                 1530             


Asn Leu  Thr Glu Met Glu Lys  Val Lys Lys Leu Ile  Glu Glu Glu 
    1535                 1540                 1545             


Lys Thr  Glu Val Gln Val Thr  Leu Glu Glu Thr Glu  Gly Ala Leu 
    1550                 1555                 1560             


Glu Arg  Asn Glu Ser Lys Ile  Leu His Phe Gln Leu  Glu Leu Leu 
    1565                 1570                 1575             


Glu Ala  Lys Ala Glu Leu Glu  Arg Lys Leu Ser Glu  Lys Asp Glu 
    1580                 1585                 1590             


Glu Ile  Glu Asn Phe Arg Arg  Lys Gln Gln Cys Thr  Ile Asp Ser 
    1595                 1600                 1605             


Leu Gln  Ser Ser Leu Asp Ser  Glu Ala Lys Ser Arg  Ile Glu Val 
    1610                 1615                 1620             


Thr Arg  Leu Lys Lys Lys Met  Glu Glu Asp Leu Asn  Glu Met Glu 
    1625                 1630                 1635             


Leu Gln  Leu Ser Cys Ala Asn  Arg Gln Val Ser Glu  Ala Thr Lys 
    1640                 1645                 1650             


Ser Leu  Gly Gln Leu Gln Ile  Gln Ile Lys Asp Leu  Gln Met Gln 
    1655                 1660                 1665             


Leu Asp  Asp Ser Thr Gln Leu  Asn Ser Asp Leu Lys  Glu Gln Val 
    1670                 1675                 1680             


Ala Val  Ala Glu Arg Arg Asn  Ser Leu Leu Gln Ser  Glu Leu Glu 
    1685                 1690                 1695             


Asp Leu  Arg Ser Leu Gln Glu  Gln Thr Glu Arg Gly  Arg Arg Leu 
    1700                 1705                 1710             


Ser Glu  Glu Glu Leu Leu Glu  Ala Thr Glu Arg Ile  Asn Leu Phe 
    1715                 1720                 1725             


Tyr Thr  Gln Asn Thr Ser Leu  Leu Ser Gln Lys Lys  Lys Leu Glu 
    1730                 1735                 1740             


Ala Asp  Val Ala Arg Met Gln  Lys Glu Ala Glu Glu  Val Val Gln 
    1745                 1750                 1755             


Glu Cys  Gln Asn Ala Glu Glu  Lys Ala Lys Lys Ala  Ala Ile Glu 
    1760                 1765                 1770             


Ala Ala  Asn Leu Ser Glu Glu  Leu Lys Lys Lys Gln  Asp Thr Ile 
    1775                 1780                 1785             


Ala His  Leu Glu Arg Thr Arg  Glu Asn Met Glu Gln  Thr Ile Thr 
    1790                 1795                 1800             


Asp Leu  Gln Lys Arg Leu Ala  Glu Ala Glu Gln Met  Ala Leu Met 
    1805                 1810                 1815             


Gly Ser  Arg Lys Gln Ile Gln  Lys Leu Glu Ser Arg  Val Arg Glu 
    1820                 1825                 1830             


Leu Glu  Gly Glu Leu Glu Gly  Glu Ile Arg Arg Ser  Ala Glu Ala 
    1835                 1840                 1845             


Gln Arg  Gly Ala Arg Arg Leu  Glu Arg Cys Ile Lys  Glu Leu Thr 
    1850                 1855                 1860             


Tyr Gln  Ala Glu Glu Asp Lys  Lys Asn Leu Ser Arg  Met Gln Thr 
    1865                 1870                 1875             


Gln Met  Asp Lys Leu Gln Leu  Lys Val Gln Asn Tyr  Lys Gln Gln 
    1880                 1885                 1890             


Val Glu  Val Ala Glu Thr Gln  Ala Asn Gln Tyr Leu  Ser Lys Tyr 
    1895                 1900                 1905             


Lys Lys  Gln Gln His Glu Leu  Asn Glu Val Lys Glu  Arg Ala Glu 
    1910                 1915                 1920             


Val Ala  Glu Ser Gln Val Asn  Lys Leu Lys Ile Lys  Ala Arg Glu 
    1925                 1930                 1935             


Phe Gly  Lys Lys Val Gln Glu  Glu 
    1940                 1945     


<210>  67
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu 
        115                 120                 125             


Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu 
    130                 135                 140                 


Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val 
145                 150                 155                 160 


Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile 
                165                 170                 175     


Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu 
            180                 185                 190         


Trp Phe Ile Gly His Ile Thr Gln Phe Tyr Gly Ile Ile Gly Gln Tyr 
        195                 200                 205             


Thr Asn Leu Leu Arg Leu Val Asp Phe Tyr Val Met Pro Val Val Asn 
    210                 215                 220                 


Val Asp Gly Tyr Asp Tyr Ser Trp Lys Lys Asn Arg Met Trp Arg Lys 
225                 230                 235                 240 


Asn Arg Ser Phe Tyr Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn 
                245                 250                 255     


Arg Asn Phe Ala Ser Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser 
            260                 265                 270         


Ser Cys Ser Glu Thr Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu 
        275                 280                 285             


Val Lys Ala Val Ala Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys 
    290                 295                 300                 


Ala Tyr Ile Ser Met His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr 
305                 310                 315                 320 


Ser Tyr Thr Arg Ser Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val 
                325                 330                 335     


Ala Ser Glu Ala Val Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg 
            340                 345                 350         


Tyr Thr His Gly His Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly 
        355                 360                 365             


Gly Asp Asp Trp Ile Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile 
    370                 375                 380                 


Glu Leu Arg Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr 
385                 390                 395                 400 


Ile Lys Pro Thr Cys Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala 
                405                 410                 415     


Trp His Val Ile 
            420 


<210>  68
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  69
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  69

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
            500                 505                 510         


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
        515                 520                 525             


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
    530                 535                 540                 


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
545                 550                 555                 560 


Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His 
                565                 570                 575     


Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr 
            580                 585                 590         


Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
        595                 600         


<210>  70
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210>  71
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 445 


<210>  72
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ser Asp Leu Gly Ala Val Ile Ser Leu Leu Leu Trp Gly Arg Gln 
1               5                   10                  15      


Leu Phe Ala Leu Tyr Ser Gly Asn Asp Val Thr Asp Ile Ser Asp Asp 
            20                  25                  30          


Arg Phe Pro Lys Pro Pro Glu Ile Ala Asn Gly Tyr Val Glu His Leu 
        35                  40                  45              


Phe Arg Tyr Gln Cys Lys Asn Tyr Tyr Arg Leu Arg Thr Glu Gly Asp 
    50                  55                  60                  


Gly Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val 
65                  70                  75                  80  


Gly Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn 
                85                  90                  95      


Pro Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys 
            100                 105                 110         


Gly Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr 
        115                 120                 125             


Thr Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys 
    130                 135                 140                 


Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala 
145                 150                 155                 160 


Pro Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu 
                165                 170                 175     


Lys Val Val Leu His Pro Asn Tyr His Gln Val Asp Ile Gly Leu Ile 
            180                 185                 190         


Lys Leu Lys Gln Lys Val Leu Val Asn Glu Arg Val Met Pro Ile Cys 
        195                 200                 205             


Leu Pro Ser Lys Asn Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser 
    210                 215                 220                 


Gly Trp Gly Gln Ser Asp Asn Phe Lys Leu Thr Asp His Leu Lys Tyr 
225                 230                 235                 240 


Val Met Leu Pro Val Ala Asp Gln Tyr Asp Cys Ile Thr His Tyr Glu 
                245                 250                 255     


Gly Ser Thr Cys Pro Lys Trp Lys Ala Pro Lys Ser Pro Val Gly Val 
            260                 265                 270         


Gln Pro Ile Leu Asn Glu His Thr Phe Cys Val Gly Met Ser Lys Tyr 
        275                 280                 285             


Gln Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His 
    290                 295                 300                 


Asp Leu Glu Glu Asp Thr Trp Tyr Ala Ala Gly Ile Leu Ser Phe Asp 
305                 310                 315                 320 


Lys Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser 
                325                 330                 335     


Ile Gln His Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345             


<210>  73
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  74
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Ser Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  75
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  76
<211>  1404
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      


Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          


Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              


Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  


Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  


Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      


Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         


Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             


Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 


Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg 
            180                 185                 190         


Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr 
        195                 200                 205             


Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser 
    210                 215                 220                 


Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr 
225                 230                 235                 240 


Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys 
                245                 250                 255     


Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys 
            260                 265                 270         


Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu 
        275                 280                 285             


Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr 
    290                 295                 300                 


Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp 
305                 310                 315                 320 


Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu 
                325                 330                 335     


Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro 
            340                 345                 350         


Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             


Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 


Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 


Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     


Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            420                 425                 430         


Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro 
        435                 440                 445             


Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 


Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 


Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
            500                 505                 510         


Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
        515                 520                 525             


Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    530                 535                 540                 


Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro 
545                 550                 555                 560 


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
                565                 570                 575     


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            580                 585                 590         


Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        595                 600                 605             


Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu 
    610                 615                 620                 


Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro 
625                 630                 635                 640 


Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro 
                645                 650                 655     


Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala 
            660                 665                 670         


Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        675                 680                 685             


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
    690                 695                 700                 


Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro 
705                 710                 715                 720 


Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr 
                725                 730                 735     


Thr Thr Lys Glu Pro Thr Ser Thr Thr Cys Asp Lys Pro Ala Pro Thr 
            740                 745                 750         


Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
    770                 775                 780                 


Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
785                 790                 795                 800 


Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp 
                805                 810                 815     


Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
            820                 825                 830         


Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu 
        835                 840                 845             


Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys 
    850                 855                 860                 


Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu 
865                 870                 875                 880 


Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro 
                885                 890                 895     


Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr 
            900                 905                 910         


Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro 
        915                 920                 925             


Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr 
    930                 935                 940                 


Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val 
945                 950                 955                 960 


Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu 
                965                 970                 975     


Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile 
            980                 985                 990         


Thr Thr Thr Glu Ile Met Asn Lys  Pro Glu Glu Thr Ala  Lys Pro Lys 
        995                 1000                 1005             


Asp Arg  Ala Thr Asn Ser Lys  Ala Thr Thr Pro Lys  Pro Gln Lys 
    1010                 1015                 1020             


Pro Thr  Lys Ala Pro Lys Lys  Pro Thr Ser Thr Lys  Lys Pro Lys 
    1025                 1030                 1035             


Thr Met  Pro Arg Val Arg Lys  Pro Lys Thr Thr Pro  Thr Pro Arg 
    1040                 1045                 1050             


Lys Met  Thr Ser Thr Met Pro  Glu Leu Asn Pro Thr  Ser Arg Ile 
    1055                 1060                 1065             


Ala Glu  Ala Met Leu Gln Thr  Thr Thr Arg Pro Asn  Gln Thr Pro 
    1070                 1075                 1080             


Asn Ser  Lys Leu Val Glu Val  Asn Pro Lys Ser Glu  Asp Ala Gly 
    1085                 1090                 1095             


Gly Ala  Glu Gly Glu Thr Pro  His Met Leu Leu Arg  Pro His Val 
    1100                 1105                 1110             


Phe Met  Pro Glu Val Thr Pro  Asp Met Asp Tyr Leu  Pro Arg Val 
    1115                 1120                 1125             


Pro Asn  Gln Gly Ile Ile Ile  Asn Pro Met Leu Ser  Asp Glu Thr 
    1130                 1135                 1140             


Asn Ile  Cys Asn Gly Lys Pro  Val Asp Gly Leu Thr  Thr Leu Arg 
    1145                 1150                 1155             


Asn Gly  Thr Leu Val Ala Phe  Arg Gly His Tyr Phe  Trp Met Leu 
    1160                 1165                 1170             


Ser Pro  Phe Ser Pro Pro Ser  Pro Ala Arg Arg Ile  Thr Glu Val 
    1175                 1180                 1185             


Trp Gly  Ile Pro Ser Pro Ile  Asp Thr Val Phe Thr  Arg Cys Asn 
    1190                 1195                 1200             


Cys Glu  Gly Lys Thr Phe Phe  Phe Lys Asp Ser Gln  Tyr Trp Arg 
    1205                 1210                 1215             


Phe Thr  Asn Asp Ile Lys Asp  Ala Gly Tyr Pro Lys  Pro Ile Phe 
    1220                 1225                 1230             


Lys Gly  Phe Gly Gly Leu Thr  Gly Gln Ile Val Ala  Ala Leu Ser 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Lys Asn Trp  Pro Glu Ser Val Tyr  Phe Phe Lys 
    1250                 1255                 1260             


Arg Gly  Gly Ser Ile Gln Gln  Tyr Ile Tyr Lys Gln  Glu Pro Val 
    1265                 1270                 1275             


Gln Lys  Cys Pro Gly Arg Arg  Pro Ala Leu Asn Tyr  Pro Val Tyr 
    1280                 1285                 1290             


Gly Glu  Thr Thr Gln Val Arg  Arg Arg Arg Phe Glu  Arg Ala Ile 
    1295                 1300                 1305             


Gly Pro  Ser Gln Thr His Thr  Ile Arg Ile Gln Tyr  Ser Pro Ala 
    1310                 1315                 1320             


Arg Leu  Ala Tyr Gln Asp Lys  Gly Val Leu His Asn  Glu Val Lys 
    1325                 1330                 1335             


Val Ser  Ile Leu Trp Arg Gly  Leu Pro Asn Val Val  Thr Ser Ala 
    1340                 1345                 1350             


Ile Ser  Leu Pro Asn Ile Arg  Lys Pro Asp Gly Tyr  Asp Tyr Tyr 
    1355                 1360                 1365             


Ala Phe  Ser Lys Asp Gln Tyr  Tyr Asn Ile Asp Val  Pro Ser Arg 
    1370                 1375                 1380             


Thr Ala  Arg Ala Ile Thr Thr  Arg Ser Gly Gln Thr  Leu Ser Lys 
    1385                 1390                 1395             


Val Trp  Tyr Asn Cys Pro 
    1400                 


<210>  77
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ser Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  78
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys 
145                 150                 155                 160 


Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys 
                165                 170                 175     


Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr 
            180                 185                 190         


Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp 
        195                 200                 205             


Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 
    210                 215                 220                 


Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 
225                 230                 235                 240 


Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg 
                245                 250                 255     


Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp 
            260                 265                 270         


Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
        275                 280                 285             


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
    290                 295                 300                 


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
305                 310                 315                 320 


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
                325                 330                 335     


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
            340                 345                 350         


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
    370                 375                 380                 


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
385                 390                 395                 400 


Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 
                405                 410                 415     


Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 
            420                 425                 430         


Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 
        435                 440                 445             


Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly 
    450                 455                 460                 


Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly 
465                 470                 475                 480 


Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe 
                485                 490                 495     


Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu 
            500                 505                 510         


Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 
        515                 520                 525             


Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
    530                 535                 540             


<210>  79
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu Phe Lys 
1               5                   10                  15      


Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val 
            20                  25                  30          


Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val 
        35                  40                  45              


Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu 
    50                  55                  60                  


Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys 
65                  70                  75                  80  


Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 
                85                  90                  95      


Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 
            100                 105                 110         


Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 
        115                 120                 125             


Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys 
    130                 135                 140                 


Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn 
145                 150                 155                 160 


Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr 
                165                 170                 175     


Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln 
            180                 185                 190         


Val Glu Pro Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn 
        195                 200                 205             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr 
    210                 215                 220                 


Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr 
225                 230                 235                 240 


Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys 
                245                 250                 255     


Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly 
            260                 265                 270         


Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu 
        275                 280                 285             


Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu 
    290                 295                 300                 


Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu 
305                 310                 315                 320 


Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu 
                325                 330                 335     


Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn 
            340                 345                 350         


Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val 
        355                 360                 365             


Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile 
    370                 375                 380                 


Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr 
385                 390                 395                 400 


Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
                405                 410                 415     


Arg Ser Ile Pro Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg 
            420                 425                 430         


His Gly Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met 
        435                 440                 445             


Glu Met Arg Gln Leu Gln Arg Gly Pro Ala 
    450                 455             


<210>  80
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Asn Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
625                 630                 635             


<210>  81
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  81

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Phe Asp Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Glx Leu Leu Ile Tyr Ala Leu Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glx Ala 
                85                  90                  95      


Leu Gln Ala Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  82
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 
    50                  55                  60                  


Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val 
                85                  90                  95      


Leu Lys Gly Glu Glu 
            100     


<210>  83
<211>  4128
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln 
1               5                   10                  15      


Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His 
            20                  25                  30          


Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro 
        35                  40                  45              


Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly 
    50                  55                  60                  


Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu 
65                  70                  75                  80  


Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met 
                85                  90                  95      


Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr 
            100                 105                 110         


Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu 
        115                 120                 125             


Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met 
    130                 135                 140                 


Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu 
145                 150                 155                 160 


Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu 
                165                 170                 175     


Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn 
            180                 185                 190         


Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met 
        195                 200                 205             


Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu 
    210                 215                 220                 


Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu 
225                 230                 235                 240 


Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile 
                245                 250                 255     


Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu 
            260                 265                 270         


Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp 
        275                 280                 285             


Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr 
    290                 295                 300                 


Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu 
305                 310                 315                 320 


Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn 
                325                 330                 335     


Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val 
            340                 345                 350         


Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu 
        355                 360                 365             


Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met 
    370                 375                 380                 


Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr 
385                 390                 395                 400 


Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser 
                405                 410                 415     


Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr 
            420                 425                 430         


Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln 
        435                 440                 445             


Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val 
    450                 455                 460                 


Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser 
465                 470                 475                 480 


Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val 
                485                 490                 495     


Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly 
            500                 505                 510         


Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val 
        515                 520                 525             


Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile 
    530                 535                 540                 


Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu 
545                 550                 555                 560 


Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val 
                565                 570                 575     


Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu 
            580                 585                 590         


Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro 
        595                 600                 605             


Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile 
    610                 615                 620                 


Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu 
625                 630                 635                 640 


Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln 
                645                 650                 655     


Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile 
            660                 665                 670         


Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro 
        675                 680                 685             


Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe 
    690                 695                 700                 


Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln 
705                 710                 715                 720 


Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu 
                725                 730                 735     


Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu 
            740                 745                 750         


Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val 
        755                 760                 765             


Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val 
    770                 775                 780                 


Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu 
785                 790                 795                 800 


Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser 
                805                 810                 815     


Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys 
            820                 825                 830         


His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu 
        835                 840                 845             


Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly 
    850                 855                 860                 


Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met 
865                 870                 875                 880 


Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val 
                885                 890                 895     


Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro 
            900                 905                 910         


Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val 
        915                 920                 925             


Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys 
    930                 935                 940                 


Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln 
945                 950                 955                 960 


Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val 
                965                 970                 975     


Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile 
            980                 985                 990         


His Trp Phe Thr Asn Asn Lys Lys  Phe Glu Ser Gln Asp  Thr Val Ala 
        995                 1000                 1005             


Leu Leu  Glu Ala Ile Leu Asp  Gly Ile Val Asp Pro  Val Asp Ser 
    1010                 1015                 1020             


Thr Leu  Arg Asp Phe Cys Gly  Arg Cys Ile Arg Glu  Phe Leu Lys 
    1025                 1030                 1035             


Trp Ser  Ile Lys Gln Ile Thr  Pro Gln Gln Gln Glu  Lys Ser Pro 
    1040                 1045                 1050             


Val Asn  Thr Lys Ser Leu Phe  Lys Arg Leu Tyr Ser  Leu Ala Leu 
    1055                 1060                 1065             


His Pro  Asn Ala Phe Lys Arg  Leu Gly Ala Ser Leu  Ala Phe Asn 
    1070                 1075                 1080             


Asn Ile  Tyr Arg Glu Phe Arg  Glu Glu Glu Ser Leu  Val Glu Gln 
    1085                 1090                 1095             


Phe Val  Phe Glu Ala Leu Val  Ile Tyr Met Glu Ser  Leu Ala Leu 
    1100                 1105                 1110             


Ala His  Ala Asp Glu Lys Ser  Leu Gly Thr Ile Gln  Gln Cys Cys 
    1115                 1120                 1125             


Asp Ala  Ile Asp His Leu Cys  Arg Ile Ile Glu Lys  Lys His Val 
    1130                 1135                 1140             


Ser Leu  Asn Lys Ala Lys Lys  Arg Arg Leu Pro Arg  Gly Phe Pro 
    1145                 1150                 1155             


Pro Ser  Ala Ser Leu Cys Leu  Leu Asp Leu Val Lys  Trp Leu Leu 
    1160                 1165                 1170             


Ala His  Cys Gly Arg Pro Gln  Thr Glu Cys Arg His  Lys Ser Ile 
    1175                 1180                 1185             


Glu Leu  Phe Tyr Lys Phe Val  Pro Leu Leu Pro Gly  Asn Arg Ser 
    1190                 1195                 1200             


Pro Asn  Leu Trp Leu Lys Asp  Val Leu Lys Glu Glu  Gly Val Ser 
    1205                 1210                 1215             


Phe Leu  Ile Asn Thr Phe Glu  Gly Gly Gly Cys Gly  Gln Pro Ser 
    1220                 1225                 1230             


Gly Ile  Leu Ala Gln Pro Thr  Leu Leu Tyr Leu Arg  Gly Pro Phe 
    1235                 1240                 1245             


Ser Leu  Gln Ala Thr Leu Cys  Trp Leu Asp Leu Leu  Leu Ala Ala 
    1250                 1255                 1260             


Leu Glu  Cys Tyr Asn Thr Phe  Ile Gly Glu Arg Thr  Val Gly Ala 
    1265                 1270                 1275             


Leu Gln  Val Leu Gly Thr Glu  Ala Gln Ser Ser Leu  Leu Lys Ala 
    1280                 1285                 1290             


Val Ala  Phe Phe Leu Glu Ser  Ile Ala Met His Asp  Ile Ile Ala 
    1295                 1300                 1305             


Ala Glu  Lys Cys Phe Gly Thr  Gly Ala Ala Gly Asn  Arg Thr Ser 
    1310                 1315                 1320             


Pro Gln  Glu Gly Glu Arg Tyr  Asn Tyr Ser Lys Cys  Thr Val Val 
    1325                 1330                 1335             


Val Arg  Ile Met Glu Phe Thr  Thr Thr Leu Leu Asn  Thr Ser Pro 
    1340                 1345                 1350             


Glu Gly  Trp Lys Leu Leu Lys  Lys Asp Leu Cys Asn  Thr His Leu 
    1355                 1360                 1365             


Met Arg  Val Leu Val Gln Thr  Leu Cys Glu Pro Ala  Ser Ile Gly 
    1370                 1375                 1380             


Phe Asn  Ile Gly Asp Val Gln  Val Met Ala His Leu  Pro Asp Val 
    1385                 1390                 1395             


Cys Val  Asn Leu Met Lys Ala  Leu Lys Met Ser Pro  Tyr Lys Asp 
    1400                 1405                 1410             


Ile Leu  Glu Thr His Leu Arg  Glu Lys Ile Thr Ala  Gln Ser Ile 
    1415                 1420                 1425             


Glu Glu  Leu Cys Ala Val Asn  Leu Tyr Gly Pro Asp  Ala Gln Val 
    1430                 1435                 1440             


Asp Arg  Ser Arg Leu Ala Ala  Val Val Ser Ala Cys  Lys Gln Leu 
    1445                 1450                 1455             


His Arg  Ala Gly Leu Leu His  Asn Ile Leu Pro Ser  Gln Ser Thr 
    1460                 1465                 1470             


Asp Leu  His His Ser Val Gly  Thr Glu Leu Leu Ser  Leu Val Tyr 
    1475                 1480                 1485             


Lys Gly  Ile Ala Pro Gly Asp  Glu Arg Gln Cys Leu  Pro Ser Leu 
    1490                 1495                 1500             


Asp Leu  Ser Cys Lys Gln Leu  Ala Ser Gly Leu Leu  Glu Leu Ala 
    1505                 1510                 1515             


Phe Ala  Phe Gly Gly Leu Cys  Glu Arg Leu Val Ser  Leu Leu Leu 
    1520                 1525                 1530             


Asn Pro  Ala Val Leu Ser Thr  Ala Ser Leu Gly Ser  Ser Gln Gly 
    1535                 1540                 1545             


Ser Val  Ile His Phe Ser His  Gly Glu Tyr Phe Tyr  Ser Leu Phe 
    1550                 1555                 1560             


Ser Glu  Thr Ile Asn Thr Glu  Leu Leu Lys Asn Leu  Asp Leu Ala 
    1565                 1570                 1575             


Val Leu  Glu Leu Met Gln Ser  Ser Val Asp Asn Thr  Lys Met Val 
    1580                 1585                 1590             


Ser Ala  Val Leu Asn Gly Met  Leu Asp Gln Ser Phe  Arg Glu Arg 
    1595                 1600                 1605             


Ala Asn  Gln Lys His Gln Gly  Leu Lys Leu Ala Thr  Thr Ile Leu 
    1610                 1615                 1620             


Gln His  Trp Lys Lys Cys Asp  Ser Trp Trp Ala Lys  Asp Ser Pro 
    1625                 1630                 1635             


Leu Glu  Thr Lys Met Ala Val  Leu Ala Leu Leu Ala  Lys Ile Leu 
    1640                 1645                 1650             


Gln Ile  Asp Ser Ser Val Ser  Phe Asn Thr Ser His  Gly Ser Phe 
    1655                 1660                 1665             


Pro Glu  Val Phe Thr Thr Tyr  Ile Ser Leu Leu Ala  Asp Thr Lys 
    1670                 1675                 1680             


Leu Asp  Leu His Leu Lys Gly  Gln Ala Val Thr Leu  Leu Pro Phe 
    1685                 1690                 1695             


Phe Thr  Ser Leu Thr Gly Gly  Ser Leu Glu Glu Leu  Arg Arg Val 
    1700                 1705                 1710             


Leu Glu  Gln Leu Ile Val Ala  His Phe Pro Met Gln  Ser Arg Glu 
    1715                 1720                 1725             


Phe Pro  Pro Gly Thr Pro Arg  Phe Asn Asn Tyr Val  Asp Cys Met 
    1730                 1735                 1740             


Lys Lys  Phe Leu Asp Ala Leu  Glu Leu Ser Gln Ser  Pro Met Leu 
    1745                 1750                 1755             


Leu Glu  Leu Met Thr Glu Val  Leu Cys Arg Glu Gln  Gln His Val 
    1760                 1765                 1770             


Met Glu  Glu Leu Phe Gln Ser  Ser Phe Arg Arg Ile  Ala Arg Arg 
    1775                 1780                 1785             


Gly Ser  Cys Val Thr Gln Val  Gly Leu Leu Glu Ser  Val Tyr Glu 
    1790                 1795                 1800             


Met Phe  Arg Lys Asp Asp Pro  Arg Leu Ser Phe Thr  Arg Gln Ser 
    1805                 1810                 1815             


Phe Val  Asp Arg Ser Leu Leu  Thr Leu Leu Trp His  Cys Ser Leu 
    1820                 1825                 1830             


Asp Ala  Leu Arg Glu Phe Phe  Ser Thr Ile Val Val  Asp Ala Ile 
    1835                 1840                 1845             


Asp Val  Leu Lys Ser Arg Phe  Thr Lys Leu Asn Glu  Ser Thr Phe 
    1850                 1855                 1860             


Asp Thr  Gln Ile Thr Lys Lys  Met Gly Tyr Tyr Lys  Ile Leu Asp 
    1865                 1870                 1875             


Val Met  Tyr Ser Arg Leu Pro  Lys Asp Asp Val His  Ala Lys Glu 
    1880                 1885                 1890             


Ser Lys  Ile Asn Gln Val Phe  His Gly Ser Cys Ile  Thr Glu Gly 
    1895                 1900                 1905             


Asn Glu  Leu Thr Lys Thr Leu  Ile Lys Leu Cys Tyr  Asp Ala Phe 
    1910                 1915                 1920             


Thr Glu  Asn Met Ala Gly Glu  Asn Gln Leu Leu Glu  Arg Arg Arg 
    1925                 1930                 1935             


Leu Tyr  His Cys Ala Ala Tyr  Asn Cys Ala Ile Ser  Val Ile Cys 
    1940                 1945                 1950             


Cys Val  Phe Asn Glu Leu Lys  Phe Tyr Gln Gly Phe  Leu Phe Ser 
    1955                 1960                 1965             


Glu Lys  Pro Glu Lys Asn Leu  Leu Ile Phe Glu Asn  Leu Ile Asp 
    1970                 1975                 1980             


Leu Lys  Arg Arg Tyr Asn Phe  Pro Val Glu Val Glu  Val Pro Met 
    1985                 1990                 1995             


Glu Arg  Lys Lys Lys Tyr Ile  Glu Ile Arg Lys Glu  Ala Arg Glu 
    2000                 2005                 2010             


Ala Ala  Asn Gly Asp Ser Asp  Gly Pro Ser Tyr Met  Ser Ser Leu 
    2015                 2020                 2025             


Ser Tyr  Leu Ala Asp Ser Thr  Leu Ser Glu Glu Met  Ser Gln Phe 
    2030                 2035                 2040             


Asp Phe  Ser Thr Gly Val Gln  Ser Tyr Ser Tyr Ser  Ser Gln Asp 
    2045                 2050                 2055             


Pro Arg  Pro Ala Thr Gly Arg  Phe Arg Arg Arg Glu  Gln Arg Asp 
    2060                 2065                 2070             


Pro Thr  Val His Asp Asp Val  Leu Glu Leu Glu Met  Asp Glu Leu 
    2075                 2080                 2085             


Asn Arg  His Glu Cys Met Ala  Pro Leu Thr Ala Leu  Val Lys His 
    2090                 2095                 2100             


Met His  Arg Ser Leu Gly Pro  Pro Gln Gly Glu Glu  Asp Ser Val 
    2105                 2110                 2115             


Pro Arg  Asp Leu Pro Ser Trp  Met Lys Phe Leu His  Gly Lys Leu 
    2120                 2125                 2130             


Gly Asn  Pro Ile Val Pro Leu  Asn Ile Arg Leu Phe  Leu Ala Lys 
    2135                 2140                 2145             


Leu Val  Ile Asn Thr Glu Glu  Val Phe Arg Pro Tyr  Ala Lys His 
    2150                 2155                 2160             


Trp Leu  Ser Pro Leu Leu Gln  Leu Ala Ala Ser Glu  Asn Asn Gly 
    2165                 2170                 2175             


Gly Glu  Gly Ile His Tyr Met  Val Val Glu Ile Val  Ala Thr Ile 
    2180                 2185                 2190             


Leu Ser  Trp Thr Gly Leu Ala  Thr Pro Thr Gly Val  Pro Lys Asp 
    2195                 2200                 2205             


Glu Val  Leu Ala Asn Arg Leu  Leu Asn Phe Leu Met  Lys His Val 
    2210                 2215                 2220             


Phe His  Pro Lys Arg Ala Val  Phe Arg His Asn Leu  Glu Ile Ile 
    2225                 2230                 2235             


Lys Thr  Leu Val Glu Cys Trp  Lys Asp Cys Leu Ser  Ile Pro Tyr 
    2240                 2245                 2250             


Arg Leu  Ile Phe Glu Lys Phe  Ser Gly Lys Asp Pro  Asn Ser Lys 
    2255                 2260                 2265             


Asp Asn  Ser Val Gly Ile Gln  Leu Leu Gly Ile Val  Met Ala Asn 
    2270                 2275                 2280             


Asp Leu  Pro Pro Tyr Asp Pro  Gln Cys Gly Ile Gln  Ser Ser Glu 
    2285                 2290                 2295             


Tyr Phe  Gln Ala Leu Val Asn  Asn Met Ser Phe Val  Arg Tyr Lys 
    2300                 2305                 2310             


Glu Val  Tyr Ala Ala Ala Ala  Glu Val Leu Gly Leu  Ile Leu Arg 
    2315                 2320                 2325             


Tyr Val  Met Glu Arg Lys Asn  Ile Leu Glu Glu Ser  Leu Cys Glu 
    2330                 2335                 2340             


Leu Val  Ala Lys Gln Leu Lys  Gln His Gln Asn Thr  Met Glu Asp 
    2345                 2350                 2355             


Lys Phe  Ile Val Cys Leu Asn  Lys Val Thr Lys Ser  Phe Pro Pro 
    2360                 2365                 2370             


Leu Ala  Asp Arg Phe Met Asn  Ala Val Phe Phe Leu  Leu Pro Lys 
    2375                 2380                 2385             


Phe His  Gly Val Leu Lys Thr  Leu Cys Leu Glu Val  Val Leu Cys 
    2390                 2395                 2400             


Arg Val  Glu Gly Met Thr Glu  Leu Tyr Phe Gln Leu  Lys Ser Lys 
    2405                 2410                 2415             


Asp Phe  Val Gln Val Met Arg  His Arg Asp Asp Glu  Arg Gln Lys 
    2420                 2425                 2430             


Val Cys  Leu Asp Ile Ile Tyr  Lys Met Met Pro Lys  Leu Lys Pro 
    2435                 2440                 2445             


Val Glu  Leu Arg Glu Leu Leu  Asn Pro Val Val Glu  Phe Val Ser 
    2450                 2455                 2460             


His Pro  Ser Thr Thr Cys Arg  Glu Gln Met Tyr Asn  Ile Leu Met 
    2465                 2470                 2475             


Trp Ile  His Asp Asn Tyr Arg  Asp Pro Glu Ser Glu  Thr Asp Asn 
    2480                 2485                 2490             


Asp Ser  Gln Glu Ile Phe Lys  Leu Ala Lys Asp Val  Leu Ile Gln 
    2495                 2500                 2505             


Gly Leu  Ile Asp Glu Asn Pro  Gly Leu Gln Leu Ile  Ile Arg Asn 
    2510                 2515                 2520             


Phe Trp  Ser His Glu Thr Arg  Leu Pro Ser Asn Thr  Leu Asp Arg 
    2525                 2530                 2535             


Leu Leu  Ala Leu Asn Ser Leu  Tyr Ser Pro Lys Ile  Glu Val His 
    2540                 2545                 2550             


Phe Leu  Ser Leu Ala Thr Asn  Phe Leu Leu Glu Met  Thr Ser Met 
    2555                 2560                 2565             


Ser Pro  Asp Tyr Pro Asn Pro  Met Phe Glu His Pro  Leu Ser Glu 
    2570                 2575                 2580             


Cys Glu  Phe Gln Glu Tyr Thr  Ile Asp Ser Asp Trp  Arg Phe Arg 
    2585                 2590                 2595             


Ser Thr  Val Leu Thr Pro Met  Phe Val Glu Thr Gln  Ala Ser Gln 
    2600                 2605                 2610             


Gly Thr  Leu Gln Thr Arg Thr  Gln Glu Gly Ser Leu  Ser Ala Arg 
    2615                 2620                 2625             


Trp Pro  Val Ala Gly Gln Ile  Arg Ala Thr Gln Gln  Gln His Asp 
    2630                 2635                 2640             


Phe Thr  Leu Thr Gln Thr Ala  Asp Gly Arg Ser Ser  Phe Asp Trp 
    2645                 2650                 2655             


Leu Thr  Gly Ser Ser Thr Asp  Pro Leu Val Asp His  Thr Ser Pro 
    2660                 2665                 2670             


Ser Ser  Asp Ser Leu Leu Phe  Ala His Lys Arg Ser  Glu Arg Leu 
    2675                 2680                 2685             


Gln Arg  Ala Pro Leu Lys Ser  Val Gly Pro Asp Phe  Gly Lys Lys 
    2690                 2695                 2700             


Arg Leu  Gly Leu Pro Gly Asp  Glu Val Asp Asn Lys  Val Lys Gly 
    2705                 2710                 2715             


Ala Ala  Gly Arg Thr Asp Leu  Leu Arg Leu Arg Arg  Arg Phe Met 
    2720                 2725                 2730             


Arg Asp  Gln Glu Lys Leu Ser  Leu Met Tyr Ala Arg  Lys Gly Val 
    2735                 2740                 2745             


Ala Glu  Gln Lys Arg Glu Lys  Glu Ile Lys Ser Glu  Leu Lys Met 
    2750                 2755                 2760             


Lys Gln  Asp Ala Gln Val Val  Leu Tyr Arg Ser Tyr  Arg His Gly 
    2765                 2770                 2775             


Asp Leu  Pro Asp Ile Gln Ile  Lys His Ser Ser Leu  Ile Thr Pro 
    2780                 2785                 2790             


Leu Gln  Ala Val Ala Gln Arg  Asp Pro Ile Ile Ala  Lys Gln Leu 
    2795                 2800                 2805             


Phe Ser  Ser Leu Phe Ser Gly  Ile Leu Lys Glu Met  Asp Lys Phe 
    2810                 2815                 2820             


Lys Thr  Leu Ser Glu Lys Asn  Asn Ile Thr Gln Lys  Leu Leu Gln 
    2825                 2830                 2835             


Asp Phe  Asn Arg Phe Leu Asn  Thr Thr Phe Ser Phe  Phe Pro Pro 
    2840                 2845                 2850             


Phe Val  Ser Cys Ile Gln Asp  Ile Ser Cys Gln His  Ala Ala Leu 
    2855                 2860                 2865             


Leu Ser  Leu Asp Pro Ala Ala  Val Ser Ala Gly Cys  Leu Ala Ser 
    2870                 2875                 2880             


Leu Gln  Gln Pro Val Gly Ile  Arg Leu Leu Glu Glu  Ala Leu Leu 
    2885                 2890                 2895             


Arg Leu  Leu Pro Ala Glu Leu  Pro Ala Lys Arg Val  Arg Gly Lys 
    2900                 2905                 2910             


Ala Arg  Leu Pro Pro Asp Val  Leu Arg Trp Val Glu  Leu Ala Lys 
    2915                 2920                 2925             


Leu Tyr  Arg Ser Ile Gly Glu  Tyr Asp Val Leu Arg  Gly Ile Phe 
    2930                 2935                 2940             


Thr Ser  Glu Ile Gly Thr Lys  Gln Ile Thr Gln Ser  Ala Leu Leu 
    2945                 2950                 2955             


Ala Glu  Ala Arg Ser Asp Tyr  Ser Glu Ala Ala Lys  Gln Tyr Asp 
    2960                 2965                 2970             


Glu Ala  Leu Asn Lys Gln Asp  Trp Val Asp Gly Glu  Pro Thr Glu 
    2975                 2980                 2985             


Ala Glu  Lys Asp Phe Trp Glu  Leu Ala Ser Leu Asp  Cys Tyr Asn 
    2990                 2995                 3000             


His Leu  Ala Glu Trp Lys Ser  Leu Glu Tyr Cys Ser  Thr Ala Ser 
    3005                 3010                 3015             


Ile Asp  Ser Glu Asn Pro Pro  Asp Leu Asn Lys Ile  Trp Ser Glu 
    3020                 3025                 3030             


Pro Phe  Tyr Gln Glu Thr Tyr  Leu Pro Tyr Met Ile  Arg Ser Lys 
    3035                 3040                 3045             


Leu Lys  Leu Leu Leu Gln Gly  Glu Ala Asp Gln Ser  Leu Leu Thr 
    3050                 3055                 3060             


Phe Ile  Asp Lys Ala Met His  Gly Glu Leu Gln Lys  Ala Ile Leu 
    3065                 3070                 3075             


Glu Leu  His Tyr Ser Gln Glu  Leu Ser Leu Leu Tyr  Leu Leu Gln 
    3080                 3085                 3090             


Asp Asp  Val Asp Arg Ala Lys  Tyr Tyr Ile Gln Asn  Gly Ile Gln 
    3095                 3100                 3105             


Ser Phe  Met Gln Asn Tyr Ser  Ser Ile Asp Val Leu  Leu His Gln 
    3110                 3115                 3120             


Ser Arg  Leu Thr Lys Leu Gln  Ser Val Gln Ala Leu  Thr Glu Ile 
    3125                 3130                 3135             


Gln Glu  Phe Ile Ser Phe Ile  Ser Lys Gln Gly Asn  Leu Ser Ser 
    3140                 3145                 3150             


Gln Val  Pro Leu Lys Arg Leu  Leu Asn Thr Trp Thr  Asn Arg Tyr 
    3155                 3160                 3165             


Pro Asp  Ala Lys Met Asp Pro  Met Asn Ile Trp Asp  Asp Ile Ile 
    3170                 3175                 3180             


Thr Asn  Arg Cys Phe Phe Leu  Ser Lys Ile Glu Glu  Lys Leu Thr 
    3185                 3190                 3195             


Pro Leu  Pro Glu Asp Asn Ser  Met Asn Val Asp Gln  Asp Gly Asp 
    3200                 3205                 3210             


Pro Ser  Asp Arg Met Glu Val  Gln Glu Gln Glu Glu  Asp Ile Ser 
    3215                 3220                 3225             


Ser Leu  Ile Arg Ser Cys Lys  Phe Ser Met Lys Met  Lys Met Ile 
    3230                 3235                 3240             


Asp Ser  Ala Arg Lys Gln Asn  Asn Phe Ser Leu Ala  Met Lys Leu 
    3245                 3250                 3255             


Leu Lys  Glu Leu His Lys Glu  Ser Lys Thr Arg Asp  Asp Trp Leu 
    3260                 3265                 3270             


Val Ser  Trp Val Gln Ser Tyr  Cys Arg Leu Ser His  Cys Arg Ser 
    3275                 3280                 3285             


Arg Ser  Gln Gly Cys Ser Glu  Gln Val Leu Thr Val  Leu Lys Thr 
    3290                 3295                 3300             


Val Ser  Leu Leu Asp Glu Asn  Asn Val Ser Ser Tyr  Leu Ser Lys 
    3305                 3310                 3315             


Asn Ile  Leu Ala Phe Arg Asp  Gln Asn Ile Leu Leu  Gly Thr Thr 
    3320                 3325                 3330             


Tyr Arg  Ile Ile Ala Asn Ala  Leu Ser Ser Glu Pro  Ala Cys Leu 
    3335                 3340                 3345             


Ala Glu  Ile Glu Glu Asp Lys  Ala Arg Arg Ile Leu  Glu Leu Ser 
    3350                 3355                 3360             


Gly Ser  Ser Ser Glu Asp Ser  Glu Lys Val Ile Ala  Gly Leu Tyr 
    3365                 3370                 3375             


Gln Arg  Ala Phe Gln His Leu  Ser Glu Ala Val Gln  Ala Ala Glu 
    3380                 3385                 3390             


Glu Glu  Ala Gln Pro Pro Ser  Trp Ser Cys Gly Pro  Ala Ala Gly 
    3395                 3400                 3405             


Val Ile  Asp Ala Tyr Met Thr  Leu Ala Asp Phe Cys  Asp Gln Gln 
    3410                 3415                 3420             


Leu Arg  Lys Glu Glu Glu Asn  Ala Ser Val Ile Asp  Ser Ala Glu 
    3425                 3430                 3435             


Leu Gln  Ala Tyr Pro Ala Leu  Val Val Glu Lys Met  Leu Lys Ala 
    3440                 3445                 3450             


Leu Lys  Leu Asn Ser Asn Glu  Ala Arg Leu Lys Phe  Pro Arg Leu 
    3455                 3460                 3465             


Leu Gln  Ile Ile Glu Arg Tyr  Pro Glu Glu Thr Leu  Ser Leu Met 
    3470                 3475                 3480             


Thr Lys  Glu Ile Ser Ser Val  Pro Cys Trp Gln Phe  Ile Ser Trp 
    3485                 3490                 3495             


Ile Ser  His Met Val Ala Leu  Leu Asp Lys Asp Gln  Ala Val Ala 
    3500                 3505                 3510             


Val Gln  His Ser Val Glu Glu  Ile Thr Asp Asn Tyr  Pro Gln Ala 
    3515                 3520                 3525             


Ile Val  Tyr Pro Phe Ile Ile  Ser Ser Glu Ser Tyr  Ser Phe Lys 
    3530                 3535                 3540             


Asp Thr  Ser Thr Gly His Lys  Asn Lys Glu Phe Val  Ala Arg Ile 
    3545                 3550                 3555             


Lys Ser  Lys Leu Asp Gln Gly  Gly Val Ile Gln Asp  Phe Ile Asn 
    3560                 3565                 3570             


Ala Leu  Asp Gln Leu Ser Asn  Pro Glu Leu Leu Phe  Lys Asp Trp 
    3575                 3580                 3585             


Ser Asn  Asp Val Arg Ala Glu  Leu Ala Lys Thr Pro  Val Asn Lys 
    3590                 3595                 3600             


Lys Asn  Ile Glu Lys Met Tyr  Glu Arg Met Tyr Ala  Ala Leu Gly 
    3605                 3610                 3615             


Asp Pro  Lys Ala Pro Gly Leu  Gly Ala Phe Arg Arg  Lys Phe Ile 
    3620                 3625                 3630             


Gln Thr  Phe Gly Lys Glu Phe  Asp Lys His Phe Gly  Lys Gly Gly 
    3635                 3640                 3645             


Ser Lys  Leu Leu Arg Met Lys  Leu Ser Asp Phe Asn  Asp Ile Thr 
    3650                 3655                 3660             


Asn Met  Leu Leu Leu Lys Met  Asn Lys Asp Ser Lys  Pro Pro Gly 
    3665                 3670                 3675             


Asn Leu  Lys Glu Cys Ser Pro  Trp Met Ser Asp Phe  Lys Val Glu 
    3680                 3685                 3690             


Phe Leu  Arg Asn Glu Leu Glu  Ile Pro Gly Gln Tyr  Asp Gly Arg 
    3695                 3700                 3705             


Gly Lys  Pro Leu Pro Glu Tyr  His Val Arg Ile Ala  Gly Phe Asp 
    3710                 3715                 3720             


Glu Arg  Val Thr Val Met Ala  Ser Leu Arg Arg Pro  Lys Arg Ile 
    3725                 3730                 3735             


Ile Ile  Arg Gly His Asp Glu  Arg Glu His Pro Phe  Leu Val Lys 
    3740                 3745                 3750             


Gly Gly  Glu Asp Leu Arg Gln  Asp Gln Arg Val Glu  Gln Leu Phe 
    3755                 3760                 3765             


Gln Val  Met Asn Gly Ile Leu  Ala Gln Asp Ser Ala  Cys Ser Gln 
    3770                 3775                 3780             


Arg Ala  Leu Gln Leu Arg Thr  Tyr Ser Val Val Pro  Met Thr Ser 
    3785                 3790                 3795             


Arg Leu  Gly Leu Ile Glu Trp  Leu Glu Asn Thr Val  Thr Leu Lys 
    3800                 3805                 3810             


Asp Leu  Leu Leu Asn Thr Met  Ser Gln Glu Glu Lys  Ala Ala Tyr 
    3815                 3820                 3825             


Leu Ser  Asp Pro Arg Ala Pro  Pro Cys Glu Tyr Lys  Asp Trp Leu 
    3830                 3835                 3840             


Thr Lys  Met Ser Gly Lys His  Asp Val Gly Ala Tyr  Met Leu Met 
    3845                 3850                 3855             


Tyr Lys  Gly Ala Asn Arg Thr  Glu Thr Val Thr Ser  Phe Arg Lys 
    3860                 3865                 3870             


Arg Glu  Ser Lys Val Pro Ala  Asp Leu Leu Lys Arg  Ala Phe Val 
    3875                 3880                 3885             


Arg Met  Ser Thr Ser Pro Glu  Ala Phe Leu Ala Leu  Arg Ser His 
    3890                 3895                 3900             


Phe Ala  Ser Ser His Ala Leu  Ile Cys Ile Ser His  Trp Ile Leu 
    3905                 3910                 3915             


Gly Ile  Gly Asp Arg His Leu  Asn Asn Phe Met Val  Ala Met Glu 
    3920                 3925                 3930             


Thr Gly  Gly Val Ile Gly Ile  Asp Phe Gly His Ala  Phe Gly Ser 
    3935                 3940                 3945             


Ala Thr  Gln Phe Leu Pro Val  Pro Glu Leu Met Pro  Phe Arg Leu 
    3950                 3955                 3960             


Thr Arg  Gln Phe Ile Asn Leu  Met Leu Pro Met Lys  Glu Thr Gly 
    3965                 3970                 3975             


Leu Met  Tyr Ser Ile Met Val  His Ala Leu Arg Ala  Phe Arg Ser 
    3980                 3985                 3990             


Asp Pro  Gly Leu Leu Thr Asn  Thr Met Asp Val Phe  Val Lys Glu 
    3995                 4000                 4005             


Pro Ser  Phe Asp Trp Lys Asn  Phe Glu Gln Lys Met  Leu Lys Lys 
    4010                 4015                 4020             


Gly Gly  Ser Trp Ile Gln Glu  Ile Asn Val Ala Glu  Lys Asn Trp 
    4025                 4030                 4035             


Tyr Pro  Arg Gln Lys Ile Cys  Tyr Ala Lys Arg Lys  Leu Ala Gly 
    4040                 4045                 4050             


Ala Asn  Pro Ala Val Ile Thr  Cys Asp Glu Leu Leu  Leu Gly His 
    4055                 4060                 4065             


Glu Lys  Ala Pro Ala Phe Arg  Asp Tyr Val Ala Val  Ala Arg Gly 
    4070                 4075                 4080             


Ser Lys  Asp His Asn Ile Arg  Ala Gln Glu Pro Glu  Ser Gly Leu 
    4085                 4090                 4095             


Ser Glu  Glu Thr Gln Val Lys  Cys Leu Met Asp Gln  Ala Thr Asp 
    4100                 4105                 4110             


Pro Asn  Ile Leu Gly Arg Thr  Trp Glu Gly Trp Glu  Pro Trp Met 
    4115                 4120                 4125             


<210>  84
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Asp Val Arg Arg Leu Lys Val Asn Glu Leu Arg Glu Glu Leu Gln 
1               5                   10                  15      


Arg Arg Gly Leu Asp Thr Arg Gly Leu Lys Ala Glu Leu Ala Glu Arg 
            20                  25                  30          


Leu Gln Ala Ala Leu Glu Ala Glu Glu Pro Asp Asp Glu Arg Glu Leu 
        35                  40                  45              


Asp Ala Asp Asp Glu Pro Gly Arg Pro Gly His Ile Asn Glu Glu Val 
    50                  55                  60                  


Glu Thr Glu Gly Gly Ser Glu Leu Glu Gly Thr Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Pro Gly Leu Gln Pro His Ala Glu Pro Gly Gly Tyr Ser Gly Pro Asp 
                85                  90                  95      


Gly His Tyr Ala Met Asp Asn Ile Thr Arg Gln Asn Gln Phe Tyr Asp 
            100                 105                 110         


Thr Gln Val Ile Lys Gln Glu Asn Glu Ser Gly Tyr Glu Arg Arg Pro 
        115                 120                 125             


Leu Glu Met Glu Gln Gln Gln Ala Tyr Arg Pro Glu Met Lys Thr Glu 
    130                 135                 140                 


Met Lys Gln Gly Ala Pro Thr Ser Phe Leu Pro Pro Glu Ala Ser Gln 
145                 150                 155                 160 


Leu Lys Pro Asp Arg Gln Gln Phe Gln Ser Arg Lys Arg Pro Tyr Glu 
                165                 170                 175     


Glu Asn Arg Gly Arg Gly Tyr Phe Glu His Arg Glu Asp Arg Arg Gly 
            180                 185                 190         


Arg Ser Pro Gln Pro Pro Ala Glu Glu Asp Glu Asp Asp Phe Asp Asp 
        195                 200                 205             


Thr Leu Val Ala Ile Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Val 
    210                 215                 220                 


Ala Arg Asp Arg Ser Ser Gly Tyr Pro Leu Thr Ile Glu Gly Phe Ala 
225                 230                 235                 240 


Tyr Leu Trp Ser Gly Ala Arg Ala Ser Tyr Gly Val Arg Arg Gly Arg 
                245                 250                 255     


Val Cys Phe Glu Met Lys Ile Asn Glu Glu Ile Ser Val Lys His Leu 
            260                 265                 270         


Pro Ser Thr Glu Pro Asp Pro His Val Val Arg Ile Gly Trp Ser Leu 
        275                 280                 285             


Asp Ser Cys Ser Thr Gln Leu Gly Glu Glu Pro Phe Ser Tyr Gly Tyr 
    290                 295                 300                 


Gly Gly Thr Gly Lys Lys Ser Thr Asn Ser Arg Phe Glu Asn Tyr Gly 
305                 310                 315                 320 


Asp Lys Phe Ala Glu Asn Asp Val Ile Gly Cys Phe Ala Asp Phe Glu 
                325                 330                 335     


Cys Gly Asn Asp Val Glu Leu Ser Phe Thr Lys Asn Gly Lys Trp Met 
            340                 345                 350         


Gly Ile Ala Phe Arg Ile Gln Lys Glu Ala Leu Gly Gly Gln Ala Leu 
        355                 360                 365             


Tyr Pro His Val Leu Val Lys Asn Cys Ala Val Glu Phe Asn Phe Gly 
    370                 375                 380                 


Gln Arg Ala Glu Pro Tyr Cys Ser Val Leu Pro Gly Phe Thr Phe Ile 
385                 390                 395                 400 


Gln His Leu Pro Leu Ser Glu Arg Ile Arg Gly Thr Val Gly Pro Lys 
                405                 410                 415     


Ser Lys Ala Glu Cys Glu Ile Leu Met Met Val Gly Leu Pro Ala Ala 
            420                 425                 430         


Gly Lys Thr Thr Trp Ala Ile Lys His Ala Ala Ser Asn Pro Ser Lys 
        435                 440                 445             


Lys Tyr Asn Ile Leu Gly Thr Asn Ala Ile Met Asp Lys Met Arg Val 
    450                 455                 460                 


Met Gly Leu Arg Arg Gln Arg Asn Tyr Ala Gly Arg Trp Asp Val Leu 
465                 470                 475                 480 


Ile Gln Gln Ala Thr Gln Cys Leu Asn Arg Leu Ile Gln Ile Ala Ala 
                485                 490                 495     


Arg Lys Lys Arg Asn Tyr Ile Leu Asp Gln Thr Asn Val Tyr Gly Ser 
            500                 505                 510         


Ala Gln Arg Arg Lys Met Arg Pro Phe Glu Gly Phe Gln Arg Lys Ala 
        515                 520                 525             


Ile Val Ile Cys Pro Thr Asp Glu Asp Leu Lys Asp Arg Thr Ile Lys 
    530                 535                 540                 


Arg Thr Asp Glu Glu Gly Lys Asp Val Pro Asp His Ala Val Leu Glu 
545                 550                 555                 560 


Met Lys Ala Asn Phe Thr Leu Pro Asp Val Gly Asp Phe Leu Asp Glu 
                565                 570                 575     


Val Leu Phe Ile Glu Leu Gln Arg Glu Glu Ala Asp Lys Leu Val Arg 
            580                 585                 590         


Gln Tyr Asn Glu Glu Gly Arg Lys Ala Gly Pro Pro Pro Glu Lys Arg 
        595                 600                 605             


Phe Asp Asn Arg Gly Gly Gly Gly Phe Arg Gly Arg Gly Gly Gly Gly 
    610                 615                 620                 


Gly Phe Gln Arg Tyr Glu Asn Arg Gly Pro Pro Gly Gly Asn Arg Gly 
625                 630                 635                 640 


Gly Phe Gln Asn Arg Gly Gly Gly Ser Gly Gly Gly Gly Asn Tyr Arg 
                645                 650                 655     


Gly Gly Phe Asn Arg Ser Gly Gly Gly Gly Tyr Ser Gln Asn Arg Trp 
            660                 665                 670         


Gly Asn Asn Asn Arg Asp Asn Asn Asn Ser Asn Asn Arg Gly Ser Tyr 
        675                 680                 685             


Asn Arg Ala Pro Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro 
    690                 695                 700                 


Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Ser Tyr Ser Pro Ala 
705                 710                 715                 720 


Arg Asn Pro Pro Gly Ala Ser Thr Tyr Asn Lys Asn Ser Asn Ile Pro 
                725                 730                 735     


Gly Ser Ser Ala Asn Thr Ser Thr Pro Thr Val Ser Ser Tyr Ser Pro 
            740                 745                 750         


Pro Gln Pro Ser Tyr Ser Gln Pro Pro Tyr Asn Gln Gly Gly Tyr Ser 
        755                 760                 765             


Gln Gly Tyr Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Tyr 
    770                 775                 780                 


Asn Tyr Gly Ser Tyr Gly Gly Tyr Asn Pro Ala Pro Tyr Thr Pro Pro 
785                 790                 795                 800 


Pro Pro Pro Thr Ala Gln Thr Tyr Pro Gln Pro Ser Tyr Asn Gln Tyr 
                805                 810                 815     


Gln Gln Tyr Ala Gln Gln Trp Asn Gln Tyr Tyr Gln Asn Gln Gly Gln 
            820                 825                 830         


Trp Pro Pro Tyr Tyr Gly Asn Tyr Asp Tyr Gly Ser Tyr Ser Gly Asn 
        835                 840                 845             


Thr Gln Gly Gly Thr Ser Thr Gln 
    850                 855     


<210>  85
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Tyr Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Ile 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  86
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  87
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  88
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  89
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu 
1               5                   10                  15      


Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val 
            20                  25                  30          


Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys 
        35                  40                  45              


Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln 
    50                  55                  60                  


Gln Ala Leu Gln Thr Val Cys Leu Lys Gly Thr Lys Val His Met Lys 
65                  70                  75                  80  


Cys Phe Leu Ala Phe Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu 
                85                  90                  95      


Asp Cys Ile Ser Arg Gly Gly Thr Leu Gly Thr Pro Gln Thr Gly Ser 
            100                 105                 110         


Glu Asn Asp Ala Leu Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu 
        115                 120                 125             


Ala Glu Ile Trp Leu Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp 
    130                 135                 140                 


Val Asp Met Thr Gly Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu 
145                 150                 155                 160 


Ile Thr Ala Gln Pro Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu 
                165                 170                 175     


Ser Gly Ala Ala Asn Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln 
            180                 185                 190         


Leu Pro Tyr Ile Cys Gln Phe Gly Ile Val 
        195                 200         


<210>  90
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asn Gln Cys Phe Tyr Asn Ser Ser Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Val Ser Arg Tyr Glu Gly Gly 
            100                 105                 110         


Arg Glu His Val Ala His Leu Leu Phe Leu Arg Asp Thr Lys Thr Leu 
        115                 120                 125             


Met Phe Gly Ser Tyr Leu Asp Asp Glu Lys Asn Trp Gly Leu Ser Phe 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Cys Ile Pro Arg Ser Asp Val Met Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  91
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asx Phe Asx Asx Leu 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glx Asx Gly Ser Glx Glx Asx Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Gly Gly Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Thr 
        115     


<210>  92
<211>  5405
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Ala Leu Trp Ser Trp Trp Ile Leu Trp Ala Gly Ala Thr Leu 
1               5                   10                  15      


Leu Trp Gly Leu Thr Gln Glu Ala Ser Val Asp Leu Lys Asn Thr Gly 
            20                  25                  30          


Arg Glu Glu Phe Leu Thr Ala Phe Leu Gln Asn Tyr Gln Leu Ala Tyr 
        35                  40                  45              


Ser Lys Ala Tyr Pro Arg Leu Leu Ile Ser Ser Leu Ser Glu Ser Pro 
    50                  55                  60                  


Ala Ser Val Ser Ile Leu Ser Gln Ala Asp Asn Thr Ser Lys Lys Val 
65                  70                  75                  80  


Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala Lys Ala 
                85                  90                  95      


Glu Met Ile Gly Ser Lys Ile Phe Gln His Ala Val Val Ile His Ser 
            100                 105                 110         


Asp Tyr Ala Ile Ser Val Gln Ala Leu Asn Ala Lys Pro Asp Thr Ala 
        115                 120                 125             


Glu Leu Thr Leu Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr Phe 
    130                 135                 140                 


Val Leu Thr Pro Pro Gly Thr Ser Ala Arg Asn Val Lys Glu Phe Ala 
145                 150                 155                 160 


Val Val Ala Gly Ala Ala Gly Ala Ser Val Ser Val Thr Leu Lys Gly 
                165                 170                 175     


Ser Val Thr Phe Asn Gly Lys Phe Tyr Pro Ala Gly Asp Val Leu Arg 
            180                 185                 190         


Val Thr Leu Gln Pro Tyr Asn Val Ala Gln Leu Gln Ser Ser Val Asp 
        195                 200                 205             


Leu Ser Gly Ser Lys Val Thr Ala Ser Ser Pro Val Ala Val Leu Ser 
    210                 215                 220                 


Gly His Ser Cys Ala Gln Lys His Thr Thr Cys Asn His Val Val Glu 
225                 230                 235                 240 


Gln Leu Leu Pro Thr Ser Ala Trp Gly Thr His Tyr Val Val Pro Thr 
                245                 250                 255     


Leu Ala Ser Gln Ser Arg Tyr Asp Leu Ala Phe Val Val Ala Ser Gln 
            260                 265                 270         


Ala Thr Lys Leu Thr Tyr Asn His Gly Gly Ile Thr Gly Ser Arg Gly 
        275                 280                 285             


Leu Gln Ala Gly Asp Val Val Glu Phe Glu Val Arg Pro Ser Trp Pro 
    290                 295                 300                 


Leu Tyr Leu Ser Ala Asn Val Gly Ile Gln Val Leu Leu Phe Gly Thr 
305                 310                 315                 320 


Gly Ala Ile Arg Asn Glu Val Thr Tyr Asp Pro Tyr Leu Val Leu Ile 
                325                 330                 335     


Pro Asp Val Ala Ala Tyr Cys Pro Ala Tyr Val Val Lys Ser Val Pro 
            340                 345                 350         


Gly Cys Glu Gly Val Ala Leu Val Val Ala Gln Thr Lys Ala Ile Ser 
        355                 360                 365             


Gly Leu Thr Ile Asp Gly His Ala Val Gly Ala Lys Leu Thr Trp Glu 
    370                 375                 380                 


Ala Val Pro Gly Ser Glu Phe Ser Tyr Ala Glu Val Glu Leu Gly Thr 
385                 390                 395                 400 


Ala Asp Met Ile His Thr Ala Glu Ala Thr Thr Asn Leu Gly Leu Leu 
                405                 410                 415     


Thr Phe Gly Leu Ala Lys Ala Ile Gly Tyr Ala Thr Ala Ala Asp Cys 
            420                 425                 430         


Gly Arg Thr Val Leu Ser Pro Val Glu Pro Ser Cys Glu Gly Met Gln 
        435                 440                 445             


Cys Ala Ala Gly Gln Arg Cys Gln Val Val Gly Gly Lys Ala Gly Cys 
    450                 455                 460                 


Val Ala Glu Ser Thr Ala Val Cys Arg Ala Gln Gly Asp Pro His Tyr 
465                 470                 475                 480 


Thr Thr Phe Asp Gly Arg Arg Tyr Asp Met Met Gly Thr Cys Ser Tyr 
                485                 490                 495     


Thr Met Val Glu Leu Cys Ser Glu Asp Asp Thr Leu Pro Ala Phe Ser 
            500                 505                 510         


Val Glu Ala Lys Asn Glu His Arg Gly Ser Arg Arg Val Ser Tyr Val 
        515                 520                 525             


Gly Leu Val Thr Val Arg Ala Tyr Ser His Ser Val Ser Leu Thr Arg 
    530                 535                 540                 


Gly Glu Val Gly Phe Val Leu Val Asp Asn Gln Arg Ser Arg Leu Pro 
545                 550                 555                 560 


Val Ser Leu Ser Glu Gly Arg Leu Arg Val Tyr Gln Ser Gly Pro Arg 
                565                 570                 575     


Ala Val Val Glu Leu Val Phe Gly Leu Val Val Thr Tyr Asp Trp Asp 
            580                 585                 590         


Cys Gln Leu Ala Leu Ser Leu Pro Ala Arg Phe Gln Asp Gln Val Cys 
        595                 600                 605             


Gly Leu Cys Gly Asn Tyr Asn Gly Asp Pro Ala Asp Asp Phe Leu Thr 
    610                 615                 620                 


Pro Asp Gly Ala Leu Ala Pro Asp Ala Val Glu Phe Ala Ser Ser Trp 
625                 630                 635                 640 


Lys Leu Asp Asp Gly Asp Tyr Leu Cys Glu Asp Gly Cys Gln Asn Asn 
                645                 650                 655     


Cys Pro Ala Cys Thr Pro Gly Gln Ala Gln His Tyr Glu Gly Asp Arg 
            660                 665                 670         


Leu Cys Gly Met Leu Thr Lys Leu Asp Gly Pro Phe Ala Val Cys His 
        675                 680                 685             


Asp Thr Leu Asp Pro Arg Pro Phe Leu Glu Gln Cys Val Tyr Asp Leu 
    690                 695                 700                 


Cys Val Val Gly Gly Glu Arg Leu Ser Leu Cys Arg Gly Leu Ser Ala 
705                 710                 715                 720 


Tyr Ala Gln Ala Cys Leu Glu Leu Gly Ile Ser Val Gly Asp Trp Arg 
                725                 730                 735     


Ser Pro Ala Asn Cys Pro Leu Ser Cys Pro Ala Asn Ser Arg Tyr Glu 
            740                 745                 750         


Leu Cys Gly Pro Ala Cys Pro Thr Ser Cys Asn Gly Ala Ala Ala Pro 
        755                 760                 765             


Ser Asn Cys Ser Gly Arg Pro Cys Val Glu Gly Cys Val Cys Leu Pro 
    770                 775                 780                 


Gly Phe Val Ala Ser Gly Gly Ala Cys Val Pro Ala Ser Ser Cys Gly 
785                 790                 795                 800 


Cys Thr Phe Gln Gly Leu Gln Leu Ala Pro Gly Gln Glu Val Trp Ala 
                805                 810                 815     


Asp Glu Leu Cys Gln Arg Arg Cys Thr Cys Asn Gly Ala Thr His Gln 
            820                 825                 830         


Val Thr Cys Arg Asp Lys Gln Ser Cys Pro Ala Gly Glu Arg Cys Ser 
        835                 840                 845             


Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg Phe Gly Thr Cys 
    850                 855                 860                 


Gln Gly Ser Gly Asp Pro His Tyr Val Ser Phe Asp Gly Arg Arg Phe 
865                 870                 875                 880 


Asp Phe Met Gly Thr Cys Thr Tyr Leu Leu Val Gly Ser Cys Gly Gln 
                885                 890                 895     


Asn Ala Ala Leu Pro Ala Phe Arg Val Leu Val Glu Asn Glu His Arg 
            900                 905                 910         


Gly Ser Gln Thr Val Ser Tyr Thr Arg Ala Val Arg Val Glu Ala Arg 
        915                 920                 925             


Gly Val Lys Val Ala Val Arg Arg Glu Tyr Pro Gly Gln Val Leu Val 
    930                 935                 940                 


Asp Asp Val Leu Gln Tyr Leu Pro Phe Gln Ala Ala Asp Gly Gln Val 
945                 950                 955                 960 


Gln Val Phe Arg Gln Gly Arg Asp Ala Val Val Arg Thr Asp Phe Gly 
                965                 970                 975     


Leu Thr Val Thr Tyr Asp Trp Asn Ala Arg Val Thr Ala Lys Val Pro 
            980                 985                 990         


Ser Ser Tyr Ala Glu Ala Leu Cys  Gly Leu Cys Gly Asn  Phe Asn Gly 
        995                 1000                 1005             


Asp Pro  Ala Asp Asp Leu Ala  Leu Arg Gly Gly Gly  Gln Ala Ala 
    1010                 1015                 1020             


Asn Ala  Leu Ala Phe Gly Asn  Ser Trp Gln Glu Glu  Thr Arg Pro 
    1025                 1030                 1035             


Gly Cys  Gly Ala Thr Glu Pro  Gly Asp Cys Pro Lys  Leu Asp Ser 
    1040                 1045                 1050             


Leu Val  Ala Gln Gln Leu Gln  Ser Lys Asn Glu Cys  Gly Ile Leu 
    1055                 1060                 1065             


Ala Asp  Pro Lys Gly Pro Phe  Arg Glu Cys His Ser  Lys Leu Asp 
    1070                 1075                 1080             


Pro Gln  Gly Ala Val Arg Asp  Cys Val Tyr Asp Arg  Cys Leu Leu 
    1085                 1090                 1095             


Pro Gly  Gln Ser Gly Pro Leu  Cys Asp Ala Leu Ala  Thr Tyr Ala 
    1100                 1105                 1110             


Ala Ala  Cys Gln Ala Ala Gly  Ala Thr Val His Pro  Trp Arg Ser 
    1115                 1120                 1125             


Glu Glu  Leu Cys Pro Leu Ser  Cys Pro Pro His Ser  His Tyr Glu 
    1130                 1135                 1140             


Ala Cys  Ser Tyr Gly Cys Pro  Leu Ser Cys Gly Asp  Leu Pro Val 
    1145                 1150                 1155             


Pro Gly  Gly Cys Gly Ser Glu  Cys His Glu Gly Cys  Val Cys Asp 
    1160                 1165                 1170             


Glu Gly  Phe Ala Leu Ser Gly  Glu Ser Cys Leu Pro  Leu Ala Ser 
    1175                 1180                 1185             


Cys Gly  Cys Val His Gln Gly  Thr Tyr His Pro Pro  Gly Gln Thr 
    1190                 1195                 1200             


Phe Tyr  Pro Gly Pro Gly Cys  Asp Ser Leu Cys His  Cys Gln Glu 
    1205                 1210                 1215             


Gly Gly  Leu Val Ser Cys Glu  Ser Ser Ser Cys Gly  Pro His Glu 
    1220                 1225                 1230             


Ala Cys  Gln Pro Ser Gly Gly  Ser Leu Gly Cys Val  Ala Val Gly 
    1235                 1240                 1245             


Ser Ser  Thr Cys Gln Ala Ser  Gly Asp Pro His Tyr  Thr Thr Phe 
    1250                 1255                 1260             


Asp Gly  Arg Arg Phe Asp Phe  Met Gly Thr Cys Val  Tyr Val Leu 
    1265                 1270                 1275             


Ala Gln  Thr Cys Gly Thr Arg  Pro Gly Leu His Arg  Phe Ala Val 
    1280                 1285                 1290             


Leu Gln  Glu Asn Val Ala Trp  Gly Asn Gly Arg Val  Ser Val Thr 
    1295                 1300                 1305             


Arg Val  Ile Thr Val Gln Val  Ala Asn Phe Thr Leu  Arg Leu Glu 
    1310                 1315                 1320             


Gln Arg  Gln Trp Lys Val Thr  Val Asn Gly Val Asp  Met Lys Leu 
    1325                 1330                 1335             


Pro Val  Val Leu Ala Asn Gly  Gln Ile Arg Ala Ser  Gln His Gly 
    1340                 1345                 1350             


Ser Asp  Val Val Ile Glu Thr  Asp Phe Gly Leu Arg  Val Ala Tyr 
    1355                 1360                 1365             


Asp Leu  Val Tyr Tyr Val Arg  Val Thr Val Pro Gly  Asn Tyr Tyr 
    1370                 1375                 1380             


Gln Gln  Met Cys Gly Leu Cys  Gly Asn Tyr Asn Gly  Asp Pro Lys 
    1385                 1390                 1395             


Asp Asp  Phe Gln Lys Pro Asn  Gly Ser Gln Ala Gly  Asn Ala Asn 
    1400                 1405                 1410             


Glu Phe  Gly Asn Ser Trp Glu  Glu Val Val Pro Asp  Ser Pro Cys 
    1415                 1420                 1425             


Leu Pro  Pro Thr Pro Cys Pro  Pro Gly Ser Glu Asp  Cys Ile Pro 
    1430                 1435                 1440             


Ser His  Lys Cys Pro Pro Glu  Leu Glu Lys Lys Tyr  Gln Lys Glu 
    1445                 1450                 1455             


Glu Phe  Cys Gly Leu Leu Ser  Ser Pro Thr Gly Pro  Leu Ser Ser 
    1460                 1465                 1470             


Cys His  Lys Leu Val Asp Pro  Gln Gly Pro Leu Lys  Asp Cys Ile 
    1475                 1480                 1485             


Phe Asp  Leu Cys Leu Gly Gly  Gly Asn Leu Ser Ile  Leu Cys Ser 
    1490                 1495                 1500             


Asn Ile  His Ala Tyr Val Ser  Ala Cys Gln Ala Ala  Gly Gly His 
    1505                 1510                 1515             


Val Glu  Pro Trp Arg Thr Glu  Thr Phe Cys Pro Met  Glu Cys Pro 
    1520                 1525                 1530             


Pro Asn  Ser His Tyr Glu Leu  Cys Ala Asp Thr Cys  Ser Leu Gly 
    1535                 1540                 1545             


Cys Ser  Ala Leu Ser Ala Pro  Pro Gln Cys Gln Asp  Gly Cys Ala 
    1550                 1555                 1560             


Glu Gly  Cys Gln Cys Asp Ser  Gly Phe Leu Tyr Asn  Gly Gln Ala 
    1565                 1570                 1575             


Cys Val  Pro Ile Gln Gln Cys  Gly Cys Tyr His Asn  Gly Val Tyr 
    1580                 1585                 1590             


Tyr Glu  Pro Glu Gln Thr Val  Leu Ile Asp Asn Cys  Arg Gln Gln 
    1595                 1600                 1605             


Cys Thr  Cys His Ala Gly Lys  Gly Met Val Cys Gln  Glu His Ser 
    1610                 1615                 1620             


Cys Lys  Pro Gly Gln Val Cys  Gln Pro Ser Gly Gly  Ile Leu Ser 
    1625                 1630                 1635             


Cys Val  Thr Lys Asp Pro Cys  His Gly Val Thr Cys  Arg Pro Gln 
    1640                 1645                 1650             


Glu Thr  Cys Lys Glu Gln Gly  Gly Gln Gly Val Cys  Leu Pro Asn 
    1655                 1660                 1665             


Tyr Glu  Ala Thr Cys Trp Leu  Trp Gly Asp Pro His  Tyr His Ser 
    1670                 1675                 1680             


Phe Asp  Gly Arg Lys Phe Asp  Phe Gln Gly Thr Cys  Asn Tyr Val 
    1685                 1690                 1695             


Leu Ala  Thr Thr Gly Cys Pro  Gly Val Ser Thr Gln  Gly Leu Thr 
    1700                 1705                 1710             


Pro Phe  Thr Val Thr Thr Lys  Asn Gln Asn Arg Gly  Asn Pro Ala 
    1715                 1720                 1725             


Val Ser  Tyr Val Arg Val Val  Thr Val Ala Ala Leu  Gly Thr Asn 
    1730                 1735                 1740             


Ile Ser  Ile His Lys Asp Glu  Ile Gly Lys Val Arg  Val Asn Gly 
    1745                 1750                 1755             


Val Leu  Thr Ala Leu Pro Val  Ser Val Ala Asp Gly  Arg Ile Ser 
    1760                 1765                 1770             


Val Thr  Gln Gly Ala Ser Lys  Ala Leu Leu Val Ala  Asp Phe Gly 
    1775                 1780                 1785             


Leu Gln  Val Ser Tyr Asp Trp  Asn Trp Arg Val Asp  Val Thr Leu 
    1790                 1795                 1800             


Pro Ser  Ser Tyr His Gly Ala  Val Cys Gly Leu Cys  Gly Asn Met 
    1805                 1810                 1815             


Asp Arg  Asn Pro Asn Asn Asp  Gln Val Phe Pro Asn  Gly Thr Leu 
    1820                 1825                 1830             


Ala Pro  Ser Ile Pro Ile Trp  Gly Gly Ser Trp Arg  Ala Pro Gly 
    1835                 1840                 1845             


Trp Asp  Pro Leu Cys Trp Asp  Glu Cys Arg Gly Ser  Cys Pro Thr 
    1850                 1855                 1860             


Cys Pro  Glu Asp Arg Leu Glu  Gln Tyr Glu Gly Pro  Gly Phe Cys 
    1865                 1870                 1875             


Gly Pro  Leu Ala Pro Gly Thr  Gly Gly Pro Phe Thr  Thr Cys His 
    1880                 1885                 1890             


Ala His  Val Pro Pro Glu Ser  Phe Phe Lys Gly Cys  Val Leu Asp 
    1895                 1900                 1905             


Val Cys  Met Gly Gly Gly Asp  Arg Asp Ile Leu Cys  Lys Ala Leu 
    1910                 1915                 1920             


Ala Ser  Tyr Val Ala Ala Cys  Gln Ala Ala Gly Val  Val Ile Glu 
    1925                 1930                 1935             


Asp Trp  Arg Ala Gln Val Gly  Cys Glu Ile Thr Cys  Pro Glu Asn 
    1940                 1945                 1950             


Ser His  Tyr Glu Val Cys Gly  Ser Pro Cys Pro Ala  Ser Cys Pro 
    1955                 1960                 1965             


Ser Pro  Ala Pro Leu Thr Thr  Pro Ala Val Cys Glu  Gly Pro Cys 
    1970                 1975                 1980             


Val Glu  Gly Cys Gln Cys Asp  Ala Gly Phe Val Leu  Ser Ala Asp 
    1985                 1990                 1995             


Arg Cys  Val Pro Leu Asn Asn  Gly Cys Gly Cys Trp  Ala Asn Gly 
    2000                 2005                 2010             


Thr Tyr  His Glu Ala Gly Ser  Glu Phe Trp Ala Asp  Gly Thr Cys 
    2015                 2020                 2025             


Ser Gln  Trp Cys Arg Cys Gly  Pro Gly Gly Gly Ser  Leu Val Cys 
    2030                 2035                 2040             


Thr Pro  Ala Ser Cys Gly Leu  Gly Glu Val Cys Gly  Leu Leu Pro 
    2045                 2050                 2055             


Ser Gly  Gln His Gly Cys Gln  Pro Val Ser Thr Ala  Glu Cys Gln 
    2060                 2065                 2070             


Ala Trp  Gly Asp Pro His Tyr  Val Thr Leu Asp Gly  His Arg Phe 
    2075                 2080                 2085             


Asn Phe  Gln Gly Thr Cys Glu  Tyr Leu Leu Ser Ala  Pro Cys His 
    2090                 2095                 2100             


Gly Pro  Pro Leu Gly Ala Glu  Asn Phe Thr Val Thr  Val Ala Asn 
    2105                 2110                 2115             


Glu His  Arg Gly Ser Gln Ala  Val Ser Tyr Thr Arg  Ser Val Thr 
    2120                 2125                 2130             


Leu Gln  Ile Tyr Asn His Ser  Leu Thr Leu Ser Ala  Arg Trp Pro 
    2135                 2140                 2145             


Arg Lys  Leu Gln Val Asp Gly  Val Phe Val Thr Leu  Pro Phe Gln 
    2150                 2155                 2160             


Leu Asp  Ser Leu Leu His Ala  His Leu Ser Gly Ala  Asp Val Val 
    2165                 2170                 2175             


Val Thr  Thr Thr Ser Gly Leu  Ser Leu Ala Phe Asp  Gly Asp Ser 
    2180                 2185                 2190             


Phe Val  Arg Leu Arg Val Pro  Ala Ala Tyr Ala Gly  Ser Leu Cys 
    2195                 2200                 2205             


Gly Leu  Cys Gly Asn Tyr Asn  Gln Asp Pro Ala Asp  Asp Leu Lys 
    2210                 2215                 2220             


Ala Val  Gly Gly Lys Pro Ala  Gly Trp Gln Val Gly  Gly Ala Gln 
    2225                 2230                 2235             


Gly Cys  Gly Glu Cys Val Ser  Lys Pro Cys Pro Ser  Pro Cys Thr 
    2240                 2245                 2250             


Pro Glu  Gln Gln Glu Ser Phe  Gly Gly Pro Asp Ala  Cys Gly Val 
    2255                 2260                 2265             


Ile Ser  Ala Thr Asp Gly Pro  Leu Ala Pro Cys His  Gly Leu Val 
    2270                 2275                 2280             


Pro Pro  Ala Gln Tyr Phe Gln  Gly Cys Leu Leu Asp  Ala Cys Gln 
    2285                 2290                 2295             


Val Gln  Gly His Pro Gly Gly  Leu Cys Pro Ala Val  Ala Thr Tyr 
    2300                 2305                 2310             


Val Ala  Ala Cys Gln Ala Ala  Gly Ala Gln Leu Arg  Glu Trp Arg 
    2315                 2320                 2325             


Arg Pro  Asp Phe Cys Pro Phe  Gln Cys Pro Ala His  Ser His Tyr 
    2330                 2335                 2340             


Glu Leu  Cys Gly Asp Ser Cys  Pro Gly Ser Cys Pro  Ser Leu Ser 
    2345                 2350                 2355             


Ala Pro  Glu Gly Cys Glu Ser  Ala Cys Arg Glu Gly  Cys Val Cys 
    2360                 2365                 2370             


Asp Ala  Gly Phe Val Leu Ser  Gly Asp Thr Cys Val  Pro Val Gly 
    2375                 2380                 2385             


Gln Cys  Gly Cys Leu His Asp  Asp Arg Tyr Tyr Pro  Leu Gly Gln 
    2390                 2395                 2400             


Thr Phe  Tyr Pro Gly Pro Gly  Cys Asp Ser Leu Cys  Arg Cys Arg 
    2405                 2410                 2415             


Glu Gly  Gly Glu Val Ser Cys  Glu Pro Ser Ser Cys  Gly Pro His 
    2420                 2425                 2430             


Glu Thr  Cys Arg Pro Ser Gly  Gly Ser Leu Gly Cys  Val Ala Val 
    2435                 2440                 2445             


Gly Ser  Thr Thr Cys Gln Ala  Ser Gly Asp Pro His  Tyr Thr Thr 
    2450                 2455                 2460             


Phe Asp  Gly Arg Arg Phe Asp  Phe Met Gly Thr Cys  Val Tyr Val 
    2465                 2470                 2475             


Leu Ala  Gln Thr Cys Gly Thr  Arg Pro Gly Leu His  Arg Phe Ala 
    2480                 2485                 2490             


Val Leu  Gln Glu Asn Val Ala  Trp Gly Asn Gly Arg  Val Ser Val 
    2495                 2500                 2505             


Thr Arg  Val Ile Thr Val Gln  Val Ala Asn Phe Thr  Leu Arg Leu 
    2510                 2515                 2520             


Glu Gln  Arg Gln Trp Lys Val  Thr Val Asn Gly Val  Asp Met Lys 
    2525                 2530                 2535             


Leu Pro  Val Val Leu Ala Asn  Gly Gln Ile Arg Ala  Ser Gln His 
    2540                 2545                 2550             


Gly Ser  Asp Val Val Ile Glu  Thr Asp Phe Gly Leu  Arg Val Ala 
    2555                 2560                 2565             


Tyr Asp  Leu Val Tyr Tyr Val  Arg Val Thr Val Pro  Gly Asn Tyr 
    2570                 2575                 2580             


Tyr Gln  Leu Met Cys Gly Leu  Cys Gly Asn Tyr Asn  Gly Asp Pro 
    2585                 2590                 2595             


Lys Asp  Asp Phe Gln Lys Pro  Asn Gly Ser Gln Ala  Gly Asn Ala 
    2600                 2605                 2610             


Asn Glu  Phe Gly Asn Ser Trp  Glu Glu Val Val Pro  Asp Ser Pro 
    2615                 2620                 2625             


Cys Leu  Pro Pro Pro Thr Cys  Pro Pro Gly Ser Glu  Gly Cys Ile 
    2630                 2635                 2640             


Pro Ser  Glu Glu Cys Pro Pro  Glu Leu Glu Lys Lys  Tyr Gln Lys 
    2645                 2650                 2655             


Glu Glu  Phe Cys Gly Leu Leu  Ser Ser Pro Thr Gly  Pro Leu Ser 
    2660                 2665                 2670             


Ser Cys  His Lys Leu Val Asp  Pro Gln Gly Pro Leu  Lys Asp Cys 
    2675                 2680                 2685             


Ile Phe  Asp Leu Cys Leu Gly  Gly Gly Asn Leu Ser  Ile Leu Cys 
    2690                 2695                 2700             


Ser Asn  Ile His Ala Tyr Val  Ser Ala Cys Gln Ala  Ala Gly Gly 
    2705                 2710                 2715             


Gln Val  Glu Pro Trp Arg Asn  Glu Thr Phe Cys Pro  Met Glu Cys 
    2720                 2725                 2730             


Pro Gln  Asn Ser His Tyr Glu  Leu Cys Ala Asp Thr  Cys Ser Leu 
    2735                 2740                 2745             


Gly Cys  Ser Ala Leu Ser Ala  Pro Leu Gln Cys Pro  Asp Gly Cys 
    2750                 2755                 2760             


Ala Glu  Gly Cys Gln Cys Asp  Ser Gly Phe Leu Tyr  Asn Gly Gln 
    2765                 2770                 2775             


Ala Cys  Val Pro Ile Gln Gln  Cys Gly Cys Tyr His  Asn Gly Ala 
    2780                 2785                 2790             


Tyr Tyr  Glu Pro Glu Gln Thr  Val Leu Ile Asp Asn  Cys Arg Gln 
    2795                 2800                 2805             


Gln Cys  Thr Cys His Val Gly  Lys Val Val Val Cys  Gln Glu His 
    2810                 2815                 2820             


Ser Cys  Lys Pro Gly Gln Val  Cys Gln Pro Ser Gly  Gly Ile Leu 
    2825                 2830                 2835             


Ser Cys  Val Asn Lys Asp Pro  Cys His Gly Val Thr  Cys Arg Pro 
    2840                 2845                 2850             


Gln Glu  Thr Cys Lys Glu Gln  Gly Gly Gln Gly Val  Cys Leu Pro 
    2855                 2860                 2865             


Asn Tyr  Glu Ala Thr Cys Trp  Leu Trp Gly Asp Pro  His Tyr His 
    2870                 2875                 2880             


Ser Phe  Asp Gly Arg Lys Phe  Asp Phe Gln Gly Thr  Cys Asn Tyr 
    2885                 2890                 2895             


Val Leu  Ala Thr Thr Gly Cys  Pro Gly Val Ser Thr  Gln Gly Leu 
    2900                 2905                 2910             


Thr Pro  Phe Thr Val Thr Thr  Lys Asn Gln Asn Arg  Gly Asn Pro 
    2915                 2920                 2925             


Ala Val  Ser Tyr Val Arg Val  Val Thr Val Ala Ala  Leu Gly Thr 
    2930                 2935                 2940             


Asn Ile  Ser Ile His Lys Asp  Glu Ile Gly Lys Val  Arg Val Asn 
    2945                 2950                 2955             


Gly Val  Leu Thr Ala Leu Pro  Val Ser Val Ala Asp  Gly Arg Ile 
    2960                 2965                 2970             


Ser Val  Thr Gln Gly Ala Ser  Lys Ala Leu Leu Val  Ala Asp Phe 
    2975                 2980                 2985             


Gly Leu  Gln Val Ser Tyr Asp  Trp Asn Trp Arg Val  Asp Val Thr 
    2990                 2995                 3000             


Leu Pro  Ser Ser Tyr His Gly  Ala Val Cys Gly Leu  Cys Gly Asn 
    3005                 3010                 3015             


Met Asp  Arg Asn Pro Asn Asn  Asp Gln Val Phe Pro  Asn Gly Thr 
    3020                 3025                 3030             


Leu Ala  Pro Ser Ile Pro Ile  Trp Gly Gly Ser Trp  Arg Ala Pro 
    3035                 3040                 3045             


Gly Trp  Asp Pro Leu Cys Trp  Asp Glu Cys Arg Gly  Ser Cys Pro 
    3050                 3055                 3060             


Thr Cys  Pro Glu Asp Arg Leu  Glu Gln Tyr Glu Gly  Pro Gly Phe 
    3065                 3070                 3075             


Cys Gly  Pro Leu Ala Pro Gly  Thr Gly Gly Pro Phe  Thr Thr Cys 
    3080                 3085                 3090             


His Ala  His Val Pro Pro Glu  Ser Phe Phe Lys Gly  Cys Val Leu 
    3095                 3100                 3105             


Asp Val  Cys Met Gly Gly Gly  Asp Arg Asp Ile Leu  Cys Lys Ala 
    3110                 3115                 3120             


Leu Ala  Ser Tyr Val Ala Ala  Cys Gln Ala Ala Gly  Val Val Ile 
    3125                 3130                 3135             


Glu Asp  Trp Arg Ala Gln Val  Gly Cys Glu Ile Thr  Cys Pro Glu 
    3140                 3145                 3150             


Asn Ser  His Tyr Glu Val Cys  Gly Pro Pro Cys Pro  Ala Ser Cys 
    3155                 3160                 3165             


Pro Ser  Pro Ala Pro Leu Thr  Thr Pro Ala Val Cys  Glu Gly Pro 
    3170                 3175                 3180             


Cys Val  Glu Gly Cys Gln Cys  Asp Ala Gly Phe Val  Leu Ser Ala 
    3185                 3190                 3195             


Asp Arg  Cys Val Pro Leu Asn  Asn Gly Cys Gly Cys  Trp Ala Asn 
    3200                 3205                 3210             


Gly Thr  Tyr His Glu Ala Gly  Ser Glu Phe Trp Ala  Asp Gly Thr 
    3215                 3220                 3225             


Cys Ser  Gln Trp Cys Arg Cys  Gly Pro Gly Gly Gly  Ser Leu Val 
    3230                 3235                 3240             


Cys Thr  Pro Ala Ser Cys Gly  Leu Gly Glu Val Cys  Gly Leu Leu 
    3245                 3250                 3255             


Pro Ser  Gly Gln His Gly Cys  Gln Pro Val Ser Thr  Ala Glu Cys 
    3260                 3265                 3270             


Gln Ala  Trp Gly Asp Pro His  Tyr Val Thr Leu Asp  Gly His Arg 
    3275                 3280                 3285             


Phe Asp  Phe Gln Gly Thr Cys  Glu Tyr Leu Leu Ser  Ala Pro Cys 
    3290                 3295                 3300             


His Gly  Pro Pro Leu Gly Ala  Glu Asn Phe Thr Val  Thr Val Ala 
    3305                 3310                 3315             


Asn Glu  His Arg Gly Ser Gln  Ala Val Ser Tyr Thr  Arg Ser Val 
    3320                 3325                 3330             


Thr Leu  Gln Ile Tyr Asn His  Ser Leu Thr Leu Ser  Ala Arg Trp 
    3335                 3340                 3345             


Pro Arg  Lys Leu Gln Val Asp  Gly Val Phe Val Thr  Leu Pro Phe 
    3350                 3355                 3360             


Gln Leu  Asp Ser Leu Leu His  Ala His Leu Ser Gly  Ala Asp Val 
    3365                 3370                 3375             


Val Val  Thr Thr Thr Ser Gly  Leu Ser Leu Ala Phe  Asp Gly Asp 
    3380                 3385                 3390             


Ser Phe  Val Arg Leu Arg Val  Pro Ala Ala Tyr Ala  Gly Ser Leu 
    3395                 3400                 3405             


Cys Gly  Leu Cys Gly Asn Tyr  Asn Gln Asp Pro Ala  Asp Asp Leu 
    3410                 3415                 3420             


Lys Ala  Val Gly Gly Lys Pro  Ala Gly Trp Gln Val  Gly Gly Ala 
    3425                 3430                 3435             


Gln Gly  Cys Gly Glu Cys Val  Ser Lys Pro Cys Pro  Ser Pro Cys 
    3440                 3445                 3450             


Thr Pro  Glu Gln Gln Glu Ser  Phe Gly Gly Pro Asp  Ala Cys Gly 
    3455                 3460                 3465             


Val Ile  Ser Ala Thr Asp Gly  Pro Leu Ala Pro Cys  His Gly Leu 
    3470                 3475                 3480             


Val Pro  Pro Ala Gln Tyr Phe  Gln Gly Cys Leu Leu  Asp Ala Cys 
    3485                 3490                 3495             


Gln Val  Gln Gly His Pro Gly  Gly Leu Cys Pro Ala  Val Ala Thr 
    3500                 3505                 3510             


Tyr Val  Ala Ala Cys Gln Ala  Ala Gly Ala Gln Leu  Arg Glu Trp 
    3515                 3520                 3525             


Arg Arg  Pro Asp Phe Cys Pro  Phe Gln Cys Pro Ala  His Ser His 
    3530                 3535                 3540             


Tyr Glu  Leu Cys Gly Asp Ser  Cys Pro Gly Ser Cys  Pro Ser Leu 
    3545                 3550                 3555             


Ser Ala  Pro Glu Gly Cys Glu  Ser Ala Cys Arg Glu  Gly Cys Val 
    3560                 3565                 3570             


Cys Asp  Ala Gly Phe Val Leu  Ser Gly Asp Thr Cys  Val Pro Val 
    3575                 3580                 3585             


Gly Gln  Cys Gly Cys Leu His  Asp Asp Arg Tyr Tyr  Pro Leu Gly 
    3590                 3595                 3600             


Gln Thr  Phe Tyr Pro Gly Pro  Gly Cys Asp Ser Leu  Cys Arg Cys 
    3605                 3610                 3615             


Arg Glu  Gly Gly Glu Val Ser  Cys Glu Pro Ser Ser  Cys Gly Pro 
    3620                 3625                 3630             


His Glu  Thr Cys Arg Pro Ser  Gly Gly Ser Leu Gly  Cys Val Ala 
    3635                 3640                 3645             


Val Gly  Ser Thr Thr Cys Gln  Ala Ser Gly Asp Pro  His Tyr Thr 
    3650                 3655                 3660             


Thr Phe  Asp Gly His Arg Phe  Asp Phe Met Gly Thr  Cys Val Tyr 
    3665                 3670                 3675             


Val Leu  Ala Gln Thr Cys Gly  Thr Arg Pro Gly Leu  His Arg Phe 
    3680                 3685                 3690             


Ala Val  Leu Gln Glu Asn Val  Ala Trp Gly Asn Gly  Arg Val Ser 
    3695                 3700                 3705             


Val Thr  Arg Val Ile Thr Val  Gln Val Ala Asn Phe  Thr Leu Arg 
    3710                 3715                 3720             


Leu Glu  Gln Arg Gln Trp Lys  Val Thr Val Asn Gly  Val Asp Met 
    3725                 3730                 3735             


Lys Leu  Pro Val Val Leu Ala  Asn Gly Gln Ile Arg  Ala Ser Gln 
    3740                 3745                 3750             


His Gly  Ser Asp Val Val Ile  Glu Thr Asp Phe Gly  Leu Arg Val 
    3755                 3760                 3765             


Ala Tyr  Asp Leu Val Tyr Tyr  Val Arg Val Thr Val  Pro Gly Asn 
    3770                 3775                 3780             


Tyr Tyr  Gln Leu Met Cys Gly  Leu Cys Gly Asn Tyr  Asn Gly Asp 
    3785                 3790                 3795             


Pro Lys  Asp Asp Phe Gln Lys  Pro Asn Gly Ser Gln  Ala Gly Asn 
    3800                 3805                 3810             


Ala Asn  Glu Phe Gly Asn Ser  Trp Glu Glu Val Val  Pro Asp Ser 
    3815                 3820                 3825             


Pro Cys  Leu Pro Pro Pro Thr  Cys Pro Pro Gly Ser  Ala Gly Cys 
    3830                 3835                 3840             


Ile Pro  Ser Asp Lys Cys Pro  Pro Glu Leu Glu Lys  Lys Tyr Gln 
    3845                 3850                 3855             


Lys Glu  Glu Phe Cys Gly Leu  Leu Ser Ser Pro Thr  Gly Pro Leu 
    3860                 3865                 3870             


Ser Ser  Cys His Lys Leu Val  Asp Pro Gln Gly Pro  Leu Lys Asp 
    3875                 3880                 3885             


Cys Ile  Phe Asp Leu Cys Leu  Gly Gly Gly Asn Leu  Ser Ile Leu 
    3890                 3895                 3900             


Cys Ser  Asn Ile His Ala Tyr  Val Ser Ala Cys Gln  Ala Ala Gly 
    3905                 3910                 3915             


Gly His  Val Glu Pro Trp Arg  Asn Glu Thr Phe Cys  Pro Met Glu 
    3920                 3925                 3930             


Cys Pro  Gln Asn Ser His Tyr  Glu Leu Cys Ala Asp  Thr Cys Ser 
    3935                 3940                 3945             


Leu Gly  Cys Ser Ala Leu Ser  Ala Pro Leu Gln Cys  Pro Asp Gly 
    3950                 3955                 3960             


Cys Ala  Glu Gly Cys Gln Cys  Asp Ser Gly Phe Leu  Tyr Asn Gly 
    3965                 3970                 3975             


Gln Ala  Cys Val Pro Ile Gln  Gln Cys Gly Cys Tyr  His Asn Gly 
    3980                 3985                 3990             


Val Tyr  Tyr Glu Pro Glu Gln  Thr Val Leu Ile Asp  Asn Cys Arg 
    3995                 4000                 4005             


Gln Gln  Cys Thr Cys His Val  Gly Lys Val Val Val  Cys Gln Glu 
    4010                 4015                 4020             


His Ser  Cys Lys Pro Gly Gln  Val Cys Gln Pro Ser  Gly Gly Ile 
    4025                 4030                 4035             


Leu Ser  Cys Val Thr Lys Asp  Pro Cys His Gly Val  Thr Cys Arg 
    4040                 4045                 4050             


Pro Gln  Glu Thr Cys Lys Glu  Gln Gly Gly Gln Gly  Val Cys Leu 
    4055                 4060                 4065             


Pro Asn  Tyr Glu Ala Thr Cys  Trp Leu Trp Gly Asp  Pro His Tyr 
    4070                 4075                 4080             


His Ser  Phe Asp Gly Arg Lys  Phe Asp Phe Gln Gly  Thr Cys Asn 
    4085                 4090                 4095             


Tyr Val  Leu Ala Thr Thr Gly  Cys Pro Gly Val Ser  Thr Gln Gly 
    4100                 4105                 4110             


Leu Thr  Pro Phe Thr Val Thr  Thr Lys Asn Gln Asn  Arg Gly Asn 
    4115                 4120                 4125             


Pro Ala  Val Ser Tyr Val Arg  Val Val Thr Val Ala  Ala Leu Gly 
    4130                 4135                 4140             


Thr Asn  Ile Ser Ile His Lys  Asp Glu Ile Gly Lys  Val Arg Val 
    4145                 4150                 4155             


Asn Gly  Val Leu Thr Ala Leu  Pro Val Ser Val Ala  Asp Gly Arg 
    4160                 4165                 4170             


Ile Ser  Val Ala Gln Gly Ala  Ser Lys Ala Leu Leu  Val Ala Asp 
    4175                 4180                 4185             


Phe Gly  Leu Gln Val Ser Tyr  Asp Trp Asn Trp Arg  Val Asp Val 
    4190                 4195                 4200             


Thr Leu  Pro Ser Ser Tyr His  Gly Ala Val Cys Gly  Leu Cys Gly 
    4205                 4210                 4215             


Asn Met  Asp Arg Asn Pro Asn  Asn Asp Gln Val Phe  Pro Asn Gly 
    4220                 4225                 4230             


Thr Leu  Ala Pro Ser Ile Pro  Ile Trp Gly Gly Ser  Trp Arg Ala 
    4235                 4240                 4245             


Pro Gly  Trp Asp Pro Leu Cys  Trp Asp Glu Cys Arg  Gly Ser Cys 
    4250                 4255                 4260             


Pro Thr  Cys Pro Glu Asp Arg  Leu Glu Gln Tyr Glu  Gly Pro Gly 
    4265                 4270                 4275             


Phe Cys  Gly Pro Leu Ser Ser  Gly Thr Gly Gly Pro  Phe Thr Thr 
    4280                 4285                 4290             


Cys His  Ala His Val Pro Pro  Glu Ser Phe Phe Lys  Gly Cys Val 
    4295                 4300                 4305             


Leu Asp  Val Cys Met Gly Gly  Gly Asp Arg Asp Ile  Leu Cys Lys 
    4310                 4315                 4320             


Ala Leu  Ala Ser Tyr Val Ala  Ala Cys Gln Ala Ala  Gly Val Val 
    4325                 4330                 4335             


Ile Glu  Asp Trp Arg Ala Gln  Val Gly Cys Glu Ile  Thr Cys Pro 
    4340                 4345                 4350             


Glu Asn  Ser His Tyr Glu Val  Cys Gly Pro Pro Cys  Pro Ala Ser 
    4355                 4360                 4365             


Cys Pro  Ser Pro Ala Pro Leu  Thr Thr Pro Ala Val  Cys Glu Gly 
    4370                 4375                 4380             


Pro Cys  Val Glu Gly Cys Gln  Cys Asp Ala Gly Phe  Val Leu Ser 
    4385                 4390                 4395             


Ala Asp  Arg Cys Val Pro Leu  Asn Asn Gly Cys Gly  Cys Trp Ala 
    4400                 4405                 4410             


Asn Gly  Thr Tyr His Glu Ala  Gly Ser Glu Phe Trp  Ala Asp Gly 
    4415                 4420                 4425             


Thr Cys  Ser Gln Trp Cys Arg  Cys Gly Pro Gly Gly  Gly Ser Leu 
    4430                 4435                 4440             


Val Cys  Thr Pro Ala Ser Cys  Gly Leu Gly Glu Val  Cys Gly Leu 
    4445                 4450                 4455             


Leu Pro  Ser Gly Gln His Gly  Cys Gln Pro Val Ser  Thr Ala Glu 
    4460                 4465                 4470             


Cys Gln  Ala Trp Gly Asp Pro  His Tyr Val Thr Leu  Asp Gly His 
    4475                 4480                 4485             


Arg Phe  Asp Phe Gln Gly Thr  Cys Glu Tyr Leu Leu  Ser Ala Pro 
    4490                 4495                 4500             


Cys His  Gly Pro Pro Leu Gly  Ala Glu Asn Phe Thr  Val Thr Val 
    4505                 4510                 4515             


Ala Asn  Glu His Arg Gly Ser  Gln Ala Val Ser Tyr  Thr Arg Ser 
    4520                 4525                 4530             


Val Thr  Leu Gln Ile Tyr Asn  His Ser Leu Thr Leu  Ser Ala Arg 
    4535                 4540                 4545             


Trp Pro  Arg Lys Leu Gln Val  Asp Gly Val Phe Val  Ala Leu Pro 
    4550                 4555                 4560             


Phe Gln  Leu Asp Ser Leu Leu  His Ala His Leu Ser  Gly Ala Asp 
    4565                 4570                 4575             


Val Val  Val Thr Thr Thr Ser  Gly Leu Ser Leu Ala  Phe Asp Gly 
    4580                 4585                 4590             


Asp Ser  Phe Val Arg Leu Arg  Val Pro Ala Ala Tyr  Ala Ala Ser 
    4595                 4600                 4605             


Leu Cys  Gly Leu Cys Gly Asn  Tyr Asn Gln Asp Pro  Ala Asp Asp 
    4610                 4615                 4620             


Leu Lys  Ala Val Gly Gly Lys  Pro Ala Gly Trp Gln  Val Gly Gly 
    4625                 4630                 4635             


Ala Gln  Gly Cys Gly Glu Cys  Val Ser Lys Pro Cys  Pro Ser Pro 
    4640                 4645                 4650             


Cys Thr  Pro Glu Gln Gln Glu  Ser Phe Gly Gly Pro  Asp Ala Cys 
    4655                 4660                 4665             


Gly Val  Ile Ser Ala Thr Asp  Gly Pro Leu Ala Pro  Cys His Gly 
    4670                 4675                 4680             


Leu Val  Pro Pro Ala Gln Tyr  Phe Gln Gly Cys Leu  Leu Asp Ala 
    4685                 4690                 4695             


Cys Gln  Val Gln Gly His Pro  Gly Gly Leu Cys Pro  Ala Val Ala 
    4700                 4705                 4710             


Thr Tyr  Val Ala Ala Cys Gln  Ala Ala Gly Ala Gln  Leu Gly Glu 
    4715                 4720                 4725             


Trp Arg  Arg Pro Asp Phe Cys  Pro Leu Gln Cys Pro  Ala His Ser 
    4730                 4735                 4740             


His Tyr  Glu Leu Cys Gly Asp  Ser Cys Pro Val Ser  Cys Pro Ser 
    4745                 4750                 4755             


Leu Ser  Ala Pro Glu Gly Cys  Glu Ser Ala Cys Arg  Glu Gly Cys 
    4760                 4765                 4770             


Val Cys  Asp Ala Gly Phe Val  Leu Ser Gly Asp Thr  Cys Val Pro 
    4775                 4780                 4785             


Val Gly  Gln Cys Gly Cys Leu  His Asp Gly Arg Tyr  Tyr Pro Leu 
    4790                 4795                 4800             


Gly Glu  Val Phe Tyr Pro Gly  Pro Glu Cys Glu Arg  Arg Cys Glu 
    4805                 4810                 4815             


Cys Gly  Pro Gly Gly His Val  Thr Cys Gln Glu Gly  Ala Ala Cys 
    4820                 4825                 4830             


Gly Pro  His Glu Glu Cys Arg  Leu Glu Asp Gly Val  Gln Ala Cys 
    4835                 4840                 4845             


His Ala  Thr Gly Cys Gly Arg  Cys Leu Ala Asn Gly  Gly Ile His 
    4850                 4855                 4860             


Tyr Ile  Thr Leu Asp Gly Arg  Val Tyr Asp Leu His  Gly Ser Cys 
    4865                 4870                 4875             


Ser Tyr  Val Leu Ala Gln Val  Cys His Pro Lys Pro  Gly Asp Glu 
    4880                 4885                 4890             


Asp Phe  Ser Ile Val Leu Glu  Lys Asn Ala Ala Gly  Asp Leu Gln 
    4895                 4900                 4905             


Arg Leu  Leu Val Thr Val Ala  Gly Gln Val Val Ser  Leu Ala Gln 
    4910                 4915                 4920             


Gly Gln  Gln Val Thr Val Asp  Gly Glu Ala Val Ala  Leu Pro Val 
    4925                 4930                 4935             


Ala Val  Gly Arg Val Arg Val  Thr Ala Glu Gly Arg  Asn Met Val 
    4940                 4945                 4950             


Leu Gln  Thr Thr Lys Gly Leu  Arg Leu Leu Phe Asp  Gly Asp Ala 
    4955                 4960                 4965             


His Leu  Leu Met Ser Ile Pro  Ser Pro Phe Arg Gly  Arg Leu Cys 
    4970                 4975                 4980             


Gly Leu  Cys Gly Asn Phe Asn  Gly Asn Trp Ser Asp  Asp Phe Val 
    4985                 4990                 4995             


Leu Pro  Asn Gly Ser Ala Ala  Ser Ser Val Glu Thr  Phe Gly Ala 
    5000                 5005                 5010             


Ala Trp  Arg Ala Pro Gly Ser  Ser Lys Gly Cys Gly  Glu Gly Cys 
    5015                 5020                 5025             


Gly Pro  Gln Gly Cys Pro Val  Cys Leu Ala Glu Glu  Thr Ala Pro 
    5030                 5035                 5040             


Tyr Glu  Ser Asn Glu Ala Cys  Gly Gln Leu Arg Asn  Pro Gln Gly 
    5045                 5050                 5055             


Pro Phe  Ala Thr Cys Gln Ala  Val Leu Ser Pro Ser  Glu Tyr Phe 
    5060                 5065                 5070             


Arg Gln  Cys Val Tyr Asp Leu  Cys Ala Gln Lys Gly  Asp Lys Ala 
    5075                 5080                 5085             


Phe Leu  Cys Arg Ser Leu Ala  Ala Tyr Thr Ala Ala  Cys Gln Ala 
    5090                 5095                 5100             


Ala Gly  Val Ala Val Lys Pro  Trp Arg Thr Asp Ser  Phe Cys Pro 
    5105                 5110                 5115             


Leu His  Cys Pro Ala His Ser  His Tyr Ser Ile Cys  Thr Arg Thr 
    5120                 5125                 5130             


Cys Gln  Gly Ser Cys Ala Ala  Leu Ser Gly Leu Thr  Gly Cys Thr 
    5135                 5140                 5145             


Thr Arg  Cys Phe Glu Gly Cys  Glu Cys Asp Asp Arg  Phe Leu Leu 
    5150                 5155                 5160             


Ser Gln  Gly Val Cys Ile Pro  Val Gln Asp Cys Gly  Cys Thr His 
    5165                 5170                 5175             


Asn Gly  Arg Tyr Leu Pro Val  Asn Ser Ser Leu Leu  Thr Ser Asp 
    5180                 5185                 5190             


Cys Ser  Glu Arg Cys Ser Cys  Ser Ser Ser Ser Gly  Leu Thr Cys 
    5195                 5200                 5205             


Gln Ala  Ala Gly Cys Pro Pro  Gly Arg Val Cys Glu  Val Lys Ala 
    5210                 5215                 5220             


Glu Ala  Arg Asn Cys Trp Ala  Thr Arg Gly Leu Cys  Val Leu Ser 
    5225                 5230                 5235             


Val Gly  Ala Asn Leu Thr Thr  Phe Asp Gly Ala Arg  Gly Ala Thr 
    5240                 5245                 5250             


Thr Ser  Pro Gly Val Tyr Glu  Leu Ser Ser Arg Cys  Pro Gly Leu 
    5255                 5260                 5265             


Gln Asn  Thr Ile Pro Trp Tyr  Arg Val Val Ala Glu  Val Gln Ile 
    5270                 5275                 5280             


Cys His  Gly Lys Thr Glu Ala  Val Gly Gln Val His  Ile Phe Phe 
    5285                 5290                 5295             


Gln Asp  Gly Met Val Thr Leu  Thr Pro Asn Lys Gly  Val Trp Val 
    5300                 5305                 5310             


Asn Gly  Leu Arg Val Asp Leu  Pro Ala Glu Lys Leu  Ala Ser Val 
    5315                 5320                 5325             


Ser Val  Ser Arg Thr Pro Asp  Gly Ser Leu Leu Val  Arg Gln Lys 
    5330                 5335                 5340             


Ala Gly  Val Gln Val Trp Leu  Gly Ala Asn Gly Lys  Val Ala Val 
    5345                 5350                 5355             


Ile Val  Ser Asn Asp His Ala  Gly Lys Leu Cys Gly  Ala Cys Gly 
    5360                 5365                 5370             


Asn Phe  Asp Gly Asp Gln Thr  Asn Asp Trp His Asp  Ser Gln Glu 
    5375                 5380                 5385             


Lys Pro  Ala Met Glu Lys Trp  Arg Ala Gln Asp Phe  Ser Pro Cys 
    5390                 5395                 5400             


Tyr Gly  
    5405 


<210>  93
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  94
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  95
<211>  226
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (73)..(73)
<223>  Unknown residue

<400>  95

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Xaa Gly Leu Thr Gly Gln Tyr Ile 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn 
            100                 105                 110         


Ser Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser 
145                 150                 155                 160 


Glu Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys 
        195                 200                 205             


Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys 
    210                 215                 220                 


Arg Lys 
225     


<210>  96
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Pro Glu Pro Val Lys Ser Ala Pro Val Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Ile Asn Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  97
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Phe His Gln Ile Trp Ala Ala Leu Leu Tyr Phe Tyr Gly Ile Ile 
1               5                   10                  15      


Leu Asn Ser Ile Tyr Gln Cys Pro Glu His Ser Gln Leu Thr Thr Leu 
            20                  25                  30          


Gly Val Asp Gly Lys Glu Phe Pro Glu Val His Leu Gly Gln Trp Tyr 
        35                  40                  45              


Phe Ile Ala Gly Ala Ala Pro Thr Lys Glu Glu Leu Ala Thr Phe Asp 
    50                  55                  60                  


Pro Val Asp Asn Ile Val Phe Asn Met Ala Ala Gly Ser Ala Pro Met 
65                  70                  75                  80  


Gln Leu His Leu Arg Ala Thr Ile Arg Met Lys Asp Gly Leu Cys Val 
                85                  90                  95      


Pro Arg Lys Trp Ile Tyr His Leu Thr Glu Gly Ser Thr Asp Leu Arg 
            100                 105                 110         


Thr Glu Gly Arg Pro Asp Met Lys Thr Glu Leu Phe Ser Ser Ser Cys 
        115                 120                 125             


Pro Gly Gly Ile Met Leu Asn Glu Thr Gly Gln Gly Tyr Gln Arg Phe 
    130                 135                 140                 


Leu Leu Tyr Asn Arg Ser Pro His Pro Pro Glu Lys Cys Val Glu Glu 
145                 150                 155                 160 


Phe Lys Ser Leu Thr Ser Cys Leu Asp Ser Lys Ala Phe Leu Leu Thr 
                165                 170                 175     


Pro Arg Asn Gln Glu Ala Cys Glu Leu Ser Asn Asn 
            180                 185             


<210>  98
<211>  3228
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu 
            260                 265                 270         


Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His 
        275                 280                 285             


Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser 
    290                 295                 300                 


Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr 
305                 310                 315                 320 


Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly 
                325                 330                 335     


Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser 
            340                 345                 350         


Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe 
        355                 360                 365             


Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala 
    370                 375                 380                 


Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe 
385                 390                 395                 400 


Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu 
                405                 410                 415     


Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly 
            420                 425                 430         


Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro 
        435                 440                 445             


Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu 
    450                 455                 460                 


Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys 
465                 470                 475                 480 


Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His 
                485                 490                 495     


Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro 
            500                 505                 510         


Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln 
        515                 520                 525             


Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val 
    530                 535                 540                 


Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn 
545                 550                 555                 560 


Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val 
                565                 570                 575     


His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe 
            580                 585                 590         


Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys 
        595                 600                 605             


Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu 
    610                 615                 620                 


Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 
625                 630                 635                 640 


Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile 
                645                 650                 655     


Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 
            660                 665                 670         


Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 
        675                 680                 685             


Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 
    690                 695                 700                 


Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys 
705                 710                 715                 720 


Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 
                725                 730                 735     


Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu 
            740                 745                 750         


Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 
        755                 760                 765             


Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Arg 
    770                 775                 780                 


Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro 
785                 790                 795                 800 


Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln 
                805                 810                 815     


Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 
            820                 825                 830         


Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 
        835                 840                 845             


Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 
    850                 855                 860                 


Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 
865                 870                 875                 880 


Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 
                885                 890                 895     


Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln 
            900                 905                 910         


His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser 
        915                 920                 925             


Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu 
    930                 935                 940                 


Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp 
945                 950                 955                 960 


Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro 
                965                 970                 975     


Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg 
            980                 985                 990         


Ser Ala Glu Ser Lys Thr Ile Glu  Phe Gly Lys Thr Asn  Phe Val Gln 
        995                 1000                 1005             


Pro Met  Pro Gly Glu Gly Leu  Arg Pro Ser Leu Pro  Thr Gln Ala 
    1010                 1015                 1020             


His Thr  Thr Gln Pro Thr Pro  Phe Lys Phe Asn Ser  Asn Phe Lys 
    1025                 1030                 1035             


Ser Asn  Asp Gly Asp Phe Thr  Phe Ser Ser Pro Gln  Val Val Thr 
    1040                 1045                 1050             


Gln Pro  Pro Pro Ala Ala Tyr  Ser Asn Ser Glu Ser  Leu Leu Gly 
    1055                 1060                 1065             


Leu Leu  Thr Ser Asp Lys Pro  Leu Gln Gly Asp Gly  Tyr Ser Gly 
    1070                 1075                 1080             


Ala Lys  Pro Ile Pro Gly Gly  Gln Thr Ile Gly Pro  Arg Asn Thr 
    1085                 1090                 1095             


Phe Asn  Phe Gly Ser Lys Asn  Val Ser Gly Ile Ser  Phe Thr Glu 
    1100                 1105                 1110             


Asn Met  Gly Ser Ser Gln Gln  Lys Asn Ser Gly Phe  Arg Arg Ser 
    1115                 1120                 1125             


Asp Asp  Met Phe Thr Phe His  Gly Pro Gly Lys Ser  Val Phe Gly 
    1130                 1135                 1140             


Thr Pro  Thr Leu Glu Thr Ala  Asn Lys Asn His Glu  Thr Asp Gly 
    1145                 1150                 1155             


Gly Ser  Ala His Gly Asp Asp  Asp Asp Asp Gly Pro  His Phe Glu 
    1160                 1165                 1170             


Pro Val  Val Pro Leu Pro Asp  Lys Ile Glu Val Lys  Thr Gly Glu 
    1175                 1180                 1185             


Glu Asp  Glu Glu Glu Phe Phe  Cys Asn Arg Ala Lys  Leu Phe Arg 
    1190                 1195                 1200             


Phe Asp  Val Glu Ser Lys Glu  Trp Lys Glu Arg Gly  Ile Gly Asn 
    1205                 1210                 1215             


Val Lys  Ile Leu Arg His Lys  Thr Ser Gly Lys Ile  Arg Leu Leu 
    1220                 1225                 1230             


Met Arg  Arg Glu Gln Val Leu  Lys Ile Cys Ala Asn  His Tyr Ile 
    1235                 1240                 1245             


Ser Pro  Asp Met Lys Leu Thr  Pro Asn Ala Gly Ser  Asp Arg Ser 
    1250                 1255                 1260             


Phe Val  Trp His Ala Leu Asp  Tyr Ala Asp Glu Leu  Pro Lys Pro 
    1265                 1270                 1275             


Glu Gln  Leu Ala Ile Arg Phe  Lys Thr Pro Glu Glu  Ala Ala Leu 
    1280                 1285                 1290             


Phe Lys  Cys Lys Phe Glu Glu  Ala Gln Ser Ile Leu  Lys Ala Pro 
    1295                 1300                 1305             


Gly Thr  Asn Val Ala Met Ala  Ser Asn Gln Ala Val  Arg Ile Val 
    1310                 1315                 1320             


Lys Glu  Pro Thr Ser His Asp  Asn Lys Asp Ile Cys  Lys Ser Asp 
    1325                 1330                 1335             


Ala Gly  Asn Leu Asn Phe Glu  Phe Gln Val Ala Lys  Lys Glu Gly 
    1340                 1345                 1350             


Ser Trp  Trp His Cys Asn Ser  Cys Ser Leu Lys Asn  Ala Ser Thr 
    1355                 1360                 1365             


Ala Lys  Lys Cys Val Ser Cys  Gln Asn Leu Asn Pro  Ser Asn Lys 
    1370                 1375                 1380             


Glu Leu  Val Gly Pro Pro Leu  Ala Glu Thr Val Phe  Thr Pro Lys 
    1385                 1390                 1395             


Thr Ser  Pro Glu Asn Val Gln  Asp Arg Phe Ala Leu  Val Thr Pro 
    1400                 1405                 1410             


Lys Lys  Glu Gly His Trp Asp  Cys Ser Ile Cys Leu  Val Arg Asn 
    1415                 1420                 1425             


Glu Pro  Thr Val Ser Arg Cys  Ile Ala Cys Gln Asn  Thr Lys Ser 
    1430                 1435                 1440             


Ala Asn  Lys Ser Gly Ser Ser  Phe Val His Gln Ala  Ser Phe Lys 
    1445                 1450                 1455             


Phe Gly  Gln Gly Asp Leu Pro  Lys Pro Ile Asn Ser  Asp Phe Arg 
    1460                 1465                 1470             


Ser Val  Phe Ser Thr Lys Glu  Gly Gln Trp Asp Cys  Ser Ala Cys 
    1475                 1480                 1485             


Leu Val  Gln Asn Glu Gly Ser  Ser Thr Lys Cys Ala  Ala Cys Gln 
    1490                 1495                 1500             


Asn Pro  Arg Lys Gln Ser Leu  Pro Ala Thr Ser Ile  Pro Thr Pro 
    1505                 1510                 1515             


Ala Ser  Phe Lys Phe Gly Thr  Ser Glu Thr Ser Lys  Thr Leu Lys 
    1520                 1525                 1530             


Ser Gly  Phe Glu Asp Met Phe  Ala Lys Lys Glu Gly  Gln Trp Asp 
    1535                 1540                 1545             


Cys Ser  Ser Cys Leu Val Arg  Asn Glu Ala Asn Ala  Thr Arg Cys 
    1550                 1555                 1560             


Val Ala  Cys Gln Asn Pro Asp  Lys Pro Ser Pro Ser  Thr Ser Val 
    1565                 1570                 1575             


Pro Ala  Pro Ala Ser Phe Lys  Phe Gly Thr Ser Glu  Thr Ser Lys 
    1580                 1585                 1590             


Ala Pro  Lys Ser Gly Phe Glu  Gly Met Phe Thr Lys  Lys Glu Gly 
    1595                 1600                 1605             


Gln Trp  Asp Cys Ser Val Cys  Leu Val Arg Asn Glu  Ala Ser Ala 
    1610                 1615                 1620             


Thr Lys  Cys Ile Ala Cys Gln  Asn Pro Gly Lys Gln  Asn Gln Thr 
    1625                 1630                 1635             


Thr Ser  Ala Val Ser Thr Pro  Ala Ser Ser Glu Thr  Ser Lys Ala 
    1640                 1645                 1650             


Pro Lys  Ser Gly Phe Glu Gly  Met Phe Thr Lys Lys  Glu Gly Gln 
    1655                 1660                 1665             


Trp Asp  Cys Ser Val Cys Leu  Val Arg Asn Glu Ala  Ser Ala Thr 
    1670                 1675                 1680             


Lys Cys  Ile Ala Cys Gln Asn  Pro Gly Lys Gln Asn  Gln Thr Thr 
    1685                 1690                 1695             


Ser Ala  Val Ser Thr Pro Ala  Ser Ser Glu Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Lys Ser  Gly Phe Glu Gly Met  Phe Thr Lys Lys Glu  Gly Gln Trp 
    1715                 1720                 1725             


Asp Cys  Ser Val Cys Leu Val  Arg Asn Glu Ala Ser  Ala Thr Lys 
    1730                 1735                 1740             


Cys Ile  Ala Cys Gln Cys Pro  Ser Lys Gln Asn Gln  Thr Thr Ala 
    1745                 1750                 1755             


Ile Ser  Thr Pro Ala Ser Ser  Glu Ile Ser Lys Ala  Pro Lys Ser 
    1760                 1765                 1770             


Gly Phe  Glu Gly Met Phe Ile  Arg Lys Gly Gln Trp  Asp Cys Ser 
    1775                 1780                 1785             


Val Cys  Cys Val Gln Asn Glu  Ser Ser Ser Leu Lys  Cys Val Ala 
    1790                 1795                 1800             


Cys Asp  Ala Ser Lys Pro Thr  His Lys Pro Ile Ala  Glu Ala Pro 
    1805                 1810                 1815             


Ser Ala  Phe Thr Leu Gly Ser  Glu Met Lys Leu His  Asp Ser Ser 
    1820                 1825                 1830             


Gly Ser  Gln Val Gly Thr Gly  Phe Lys Ser Asn Phe  Ser Glu Lys 
    1835                 1840                 1845             


Ala Ser  Lys Phe Gly Asn Thr  Glu Gln Gly Phe Lys  Phe Gly His 
    1850                 1855                 1860             


Val Asp  Gln Glu Asn Ser Pro  Ser Phe Met Phe Gln  Gly Ser Ser 
    1865                 1870                 1875             


Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly Phe Ser  Ile Pro Val 
    1880                 1885                 1890             


Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser Glu Pro  Gly Asn Gln 
    1895                 1900                 1905             


Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn Gly Thr  Gly Phe Gln 
    1910                 1915                 1920             


Ala Gln  Asp Ile Ser Gly Gln  Lys Asn Gly Arg Gly  Val Ile Phe 
    1925                 1930                 1935             


Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala Asp Leu  Ala Lys Ser 
    1940                 1945                 1950             


Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys Lys Asp  Pro Asn Phe 
    1955                 1960                 1965             


Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
    1970                 1975                 1980             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1985                 1990                 1995             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    2000                 2005                 2010             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    2015                 2020                 2025             


Glu Glu  Asp Glu Lys Val Leu  Tyr Ser Gln Arg Val  Lys Leu Phe 
    2030                 2035                 2040             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    2045                 2050                 2055             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Leu Arg Met 
    2060                 2065                 2070             


Leu Met  Arg Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    2075                 2080                 2085             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    2090                 2095                 2100             


Ala Trp  Met Trp Leu Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    2105                 2110                 2115             


Leu Glu  Gln Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    2120                 2125                 2130             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    2135                 2140                 2145             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    2150                 2155                 2160             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    2165                 2170                 2175             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Thr Glu 
    2180                 2185                 2190             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    2195                 2200                 2205             


Thr Thr  Ile Lys Pro Asn Pro  Glu Asn Thr Gly Pro  Thr Leu Glu 
    2210                 2215                 2220             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    2225                 2230                 2235             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    2240                 2245                 2250             


Arg Lys  Asn Leu Phe Arg Phe  Gly Glu Ser Thr Thr  Gly Phe Asn 
    2255                 2260                 2265             


Phe Ser  Phe Lys Ser Ala Leu  Ser Pro Ser Lys Ser  Pro Ala Lys 
    2270                 2275                 2280             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    2285                 2290                 2295             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    2300                 2305                 2310             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    2315                 2320                 2325             


Glu Gln  Val Val Phe Ser His  Arg Ala Lys Leu Tyr  Arg Tyr Asp 
    2330                 2335                 2340             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    2345                 2350                 2355             


Ile Leu  Gln Asn Tyr Asp Asn  Lys Gln Val Arg Ile  Val Met Arg 
    2360                 2365                 2370             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    2375                 2380                 2385             


Asp Met  Thr Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Leu 
    2390                 2395                 2400             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    2405                 2410                 2415             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    2420                 2425                 2430             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    2435                 2440                 2445             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    2450                 2455                 2460             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    2465                 2470                 2475             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Thr Ser 
    2480                 2485                 2490             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Pro  Lys Ala Val 
    2495                 2500                 2505             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Ser 
    2510                 2515                 2520             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    2525                 2530                 2535             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    2540                 2545                 2550             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    2555                 2560                 2565             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    2570                 2575                 2580             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Phe Ala 
    2585                 2590                 2595             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    2600                 2605                 2610             


Pro Glu  Lys Ala Lys Glu Lys  Lys Lys Pro Glu Asp  Ser Pro Ser 
    2615                 2620                 2625             


Asp Asp  Asp Val Leu Ile Val  Tyr Glu Leu Thr Pro  Thr Ala Glu 
    2630                 2635                 2640             


Gln Lys  Ala Leu Ala Thr Lys  Leu Lys Leu Pro Pro  Thr Phe Phe 
    2645                 2650                 2655             


Cys Tyr  Lys Asn Arg Pro Asp  Tyr Val Ser Glu Glu  Glu Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Phe Glu Thr Ala  Val Lys Lys Leu Asn  Gly Lys Leu 
    2675                 2680                 2685             


Tyr Leu  Asp Gly Ser Glu Lys  Cys Arg Pro Leu Glu  Glu Asn Thr 
    2690                 2695                 2700             


Ala Asp  Asn Glu Lys Glu Cys  Ile Ile Val Trp Glu  Lys Lys Pro 
    2705                 2710                 2715             


Thr Val  Glu Glu Lys Ala Lys  Ala Asp Thr Leu Lys  Leu Pro Pro 
    2720                 2725                 2730             


Thr Phe  Phe Cys Gly Val Cys  Ser Asp Thr Asp Glu  Asp Asn Gly 
    2735                 2740                 2745             


Asn Gly  Glu Asp Phe Gln Ser  Glu Leu Gln Lys Val  Gln Glu Ala 
    2750                 2755                 2760             


Gln Lys  Ser Gln Thr Glu Glu  Ile Thr Ser Thr Thr  Asp Ser Val 
    2765                 2770                 2775             


Tyr Thr  Gly Gly Thr Glu Val  Met Val Pro Ser Phe  Cys Lys Ser 
    2780                 2785                 2790             


Glu Glu  Pro Asp Ser Ile Thr  Lys Ser Ile Ser Ser  Pro Ser Val 
    2795                 2800                 2805             


Ser Ser  Glu Thr Met Asp Lys  Pro Val Asp Leu Ser  Thr Arg Lys 
    2810                 2815                 2820             


Glu Ile  Asp Thr Asp Ser Thr  Ser Gln Gly Glu Ser  Lys Ile Val 
    2825                 2830                 2835             


Ser Phe  Gly Phe Gly Ser Ser  Thr Gly Leu Ser Phe  Ala Asp Leu 
    2840                 2845                 2850             


Ala Ser  Ser Asn Ser Gly Asp  Phe Ala Phe Gly Ser  Lys Asp Lys 
    2855                 2860                 2865             


Asn Phe  Gln Trp Ala Asn Thr  Gly Ala Ala Val Phe  Gly Thr Gln 
    2870                 2875                 2880             


Ser Val  Gly Thr Gln Ser Ala  Gly Lys Val Gly Glu  Asp Glu Asp 
    2885                 2890                 2895             


Gly Ser  Asp Glu Glu Val Val  His Asn Glu Asp Ile  His Phe Glu 
    2900                 2905                 2910             


Pro Ile  Val Ser Leu Pro Glu  Val Glu Val Lys Ser  Gly Glu Glu 
    2915                 2920                 2925             


Asp Glu  Glu Ile Leu Phe Lys  Glu Arg Ala Lys Leu  Tyr Arg Trp 
    2930                 2935                 2940             


Asp Arg  Asp Val Ser Gln Trp  Lys Glu Arg Gly Val  Gly Asp Ile 
    2945                 2950                 2955             


Lys Ile  Leu Trp His Thr Met  Lys Asn Tyr Tyr Arg  Ile Leu Met 
    2960                 2965                 2970             


Arg Arg  Asp Gln Val Phe Lys  Val Cys Ala Asn His  Val Ile Thr 
    2975                 2980                 2985             


Lys Thr  Met Glu Leu Lys Pro  Leu Asn Val Ser Asn  Asn Ala Leu 
    2990                 2995                 3000             


Val Trp  Thr Ala Ser Asp Tyr  Ala Asp Gly Glu Ala  Lys Val Glu 
    3005                 3010                 3015             


Gln Leu  Ala Val Arg Phe Lys  Thr Lys Glu Val Ala  Asp Cys Phe 
    3020                 3025                 3030             


Lys Lys  Thr Phe Glu Glu Cys  Gln Gln Asn Leu Met  Lys Leu Gln 
    3035                 3040                 3045             


Lys Gly  His Val Ser Leu Ala  Ala Glu Leu Ser Lys  Glu Thr Asn 
    3050                 3055                 3060             


Pro Val  Val Phe Phe Asp Val  Cys Ala Asp Gly Glu  Pro Leu Gly 
    3065                 3070                 3075             


Arg Ile  Thr Met Glu Leu Phe  Ser Asn Ile Val Pro  Arg Thr Ala 
    3080                 3085                 3090             


Glu Asn  Phe Arg Ala Leu Cys  Thr Gly Glu Lys Gly  Phe Gly Phe 
    3095                 3100                 3105             


Lys Asn  Ser Ile Phe His Arg  Val Ile Pro Asp Phe  Val Cys Gln 
    3110                 3115                 3120             


Gly Gly  Asp Ile Thr Lys His  Asp Gly Thr Gly Gly  Gln Ser Ile 
    3125                 3130                 3135             


Tyr Gly  Asp Lys Phe Glu Asp  Glu Asn Phe Asp Val  Lys His Thr 
    3140                 3145                 3150             


Gly Pro  Gly Leu Leu Ser Met  Ala Asn Gln Gly Gln  Asn Thr Asn 
    3155                 3160                 3165             


Asn Ser  Gln Phe Val Ile Thr  Leu Lys Lys Ala Glu  His Leu Asp 
    3170                 3175                 3180             


Phe Lys  His Val Val Phe Gly  Phe Val Lys Asp Gly  Met Asp Thr 
    3185                 3190                 3195             


Val Lys  Lys Ile Glu Ser Phe  Gly Ser Pro Lys Gly  Ser Val Cys 
    3200                 3205                 3210             


Arg Arg  Ile Thr Ile Thr Glu  Cys Gly Gln Ile His  Ile Asp Glu 
    3215                 3220                 3225             


<210>  99
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ile Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Asp Ser Lys 
                85                  90                  95      


Met Phe Gly Gln Gly Thr Lys Val Glu Val Lys Gly 
            100                 105             


<210>  100
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Asn Ala Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Glu Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg 
            100                 105             


<210>  101
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Arg Phe Met Thr Leu Leu Phe Leu Thr Ala Leu Ala Gly Ala Leu 
1               5                   10                  15      


Val Cys Ala Tyr Asp Pro Glu Ala Ala Ser Ala Pro Gly Ser Gly Asn 
            20                  25                  30          


Pro Cys His Glu Ala Ser Ala Ala Gln Lys Glu Asn Ala Gly Glu Asp 
        35                  40                  45              


Pro Gly Leu Ala Arg Gln Ala Pro Lys Pro Arg Lys Gln Arg Ser Ser 
    50                  55                  60                  


Leu Leu Glu Lys Gly Leu Asp Gly Ala Lys Lys Ala Val Gly Gly Leu 
65                  70                  75                  80  


Gly Lys Leu Gly Lys Asp Ala Val Glu Asp Leu Glu Ser Val Gly Lys 
                85                  90                  95      


Gly Ala Val His Asp Val Lys Asp Val Leu Asp Ser Val Leu 
            100                 105                 110 


<210>  102
<211>  1065
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Pro Ala Pro Leu Gly Val Pro Glu Glu Gln Leu Leu Gly Cys 
1               5                   10                  15      


Arg Ser Arg Val Leu Ser Arg Leu Leu Phe Ile Ala Gln Thr Ala Leu 
            20                  25                  30          


Leu Leu Leu Pro Ala Ala Gly Ala Gly Leu Cys Pro Ala Pro Cys Ser 
        35                  40                  45              


Cys Arg Ile Pro Leu Leu Asp Cys Ser Arg Arg Lys Leu Pro Ala Pro 
    50                  55                  60                  


Ser Trp Arg Ala Leu Ser Gly Leu Leu Pro Pro Asp Thr Ala Ile Leu 
65                  70                  75                  80  


Asp Phe Ser His Asn Arg Leu Ser Asn Trp Asn Ile Ser Leu Glu Ser 
                85                  90                  95      


Gln Thr Leu Gln Glu Val Lys Met Asn Tyr Asn Glu Leu Thr Glu Ile 
            100                 105                 110         


Pro Tyr Phe Gly Glu Pro Thr Ser Asn Ile Thr Leu Leu Ser Leu Val 
        115                 120                 125             


His Asn Ile Ile Pro Glu Ile Asn Ala Gln Ala Leu Gln Phe Tyr Pro 
    130                 135                 140                 


Ala Leu Glu Ser Leu Asp Leu Ser Ser Asn Ile Ile Ser Glu Ile Lys 
145                 150                 155                 160 


Thr Ser Ser Phe Pro Arg Met Gln Leu Lys Tyr Leu Asn Leu Ser Asn 
                165                 170                 175     


Asn Arg Ile Thr Thr Leu Glu Ala Gly Cys Phe Asp Asn Leu Ser Ser 
            180                 185                 190         


Ser Leu Leu Val Val Lys Leu Asn Arg Asn Arg Met Ser Met Ile Pro 
        195                 200                 205             


Pro Lys Ile Phe Lys Leu Pro His Leu Gln Phe Leu Glu Leu Lys Arg 
    210                 215                 220                 


Asn Arg Ile Lys Ile Val Glu Gly Leu Thr Phe Gln Gly Leu Asp Ser 
225                 230                 235                 240 


Leu Arg Ser Leu Lys Met Gln Arg Asn Gly Ile Ser Lys Leu Lys Asp 
                245                 250                 255     


Gly Ala Phe Phe Gly Leu Asn Asn Met Glu Glu Leu Glu Leu Glu His 
            260                 265                 270         


Asn Asn Leu Thr Arg Val Asn Lys Gly Trp Leu Tyr Gly Leu Arg Met 
        275                 280                 285             


Leu Gln Gln Leu Tyr Val Ser Gln Asn Ala Ile Glu Arg Ile Ser Pro 
    290                 295                 300                 


Asp Ala Trp Glu Phe Cys Gln Arg Leu Ser Glu Leu Asp Leu Ser Tyr 
305                 310                 315                 320 


Asn Gln Leu Thr Arg Leu Asp Glu Ser Ala Phe Val Gly Leu Ser Leu 
                325                 330                 335     


Leu Glu Arg Leu Asn Leu Gly Asp Asn Arg Val Thr His Ile Ala Asp 
            340                 345                 350         


Gly Val Phe Arg Phe Leu Ser Asn Leu Gln Thr Leu Asp Leu Arg Asn 
        355                 360                 365             


Asn Glu Ile Ser Trp Ala Ile Glu Asp Ala Ser Glu Ala Phe Ala Gly 
    370                 375                 380                 


Leu Thr Ser Leu Thr Lys Leu Ile Leu Gln Gly Asn Gln Ile Lys Ser 
385                 390                 395                 400 


Ile Thr Lys Lys Ala Phe Ile Gly Leu Glu Ser Leu Glu His Leu Asp 
                405                 410                 415     


Leu Asn Asn Asn Ala Ile Met Ser Ile Gln Glu Asn Ala Phe Ser Gln 
            420                 425                 430         


Thr His Leu Lys Glu Leu Ile Leu Asn Thr Ser Ser Leu Leu Cys Asp 
        435                 440                 445             


Cys His Leu Lys Trp Leu Leu Gln Trp Leu Val Asp Asn Asn Phe Gln 
    450                 455                 460                 


His Ser Val Asn Val Ser Cys Ala His Pro Glu Trp Leu Ala Gly Gln 
465                 470                 475                 480 


Ser Ile Leu Asn Val Asp Leu Lys Asp Phe Val Cys Asp Asp Phe Leu 
                485                 490                 495     


Lys Pro Gln Ile Arg Thr His Pro Glu Thr Ile Ile Ala Leu Arg Gly 
            500                 505                 510         


Met Asn Val Thr Leu Thr Cys Thr Ala Val Ser Ser Ser Asp Ser Pro 
        515                 520                 525             


Met Ser Thr Val Trp Arg Lys Asp Ser Glu Ile Leu Tyr Asp Val Asp 
    530                 535                 540                 


Thr Glu Asn Phe Val Arg Tyr Trp Gln Gln Ala Gly Glu Ala Leu Glu 
545                 550                 555                 560 


Tyr Thr Ser Ile Leu His Leu Phe Asn Val Asn Phe Thr Asp Glu Gly 
                565                 570                 575     


Lys Tyr Gln Cys Ile Val Thr Asn His Phe Gly Ser Asn Tyr Ser Gln 
            580                 585                 590         


Lys Ala Lys Leu Thr Val Asn Glu Met Pro Ser Phe Leu Lys Thr Pro 
        595                 600                 605             


Met Asp Leu Thr Ile Arg Thr Gly Ala Met Ala Arg Leu Glu Cys Ala 
    610                 615                 620                 


Ala Glu Gly His Pro Ala Pro Gln Ile Ser Trp Gln Lys Asp Gly Gly 
625                 630                 635                 640 


Thr Asp Phe Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro Glu 
                645                 650                 655     


Asp Asp Val Phe Phe Ile Ala Asn Val Lys Ile Glu Asp Met Gly Ile 
            660                 665                 670         


Tyr Ser Cys Met Ala Gln Asn Thr Ala Gly Gly Leu Ser Ala Asn Ala 
        675                 680                 685             


Ser Leu Thr Val Leu Glu Thr Pro Ser Phe Ile Arg Pro Leu Glu Asp 
    690                 695                 700                 


Lys Thr Val Thr Arg Gly Glu Thr Ala Val Leu Gln Cys Ile Ala Gly 
705                 710                 715                 720 


Gly Ser Pro Ala Pro Arg Leu Asn Trp Thr Lys Asp Asp Gly Pro Leu 
                725                 730                 735     


Leu Val Thr Glu Arg His Phe Phe Ala Ala Ala Asn Gln Leu Leu Ile 
            740                 745                 750         


Ile Val Asp Ala Gly Leu Glu Asp Ala Gly Lys Tyr Thr Cys Ile Met 
        755                 760                 765             


Ser Asn Thr Leu Gly Thr Glu Arg Gly His Ile Tyr Leu Asn Val Ile 
    770                 775                 780                 


Ser Ser Pro Asn Cys Asp Ser Ser Gln Ser Ser Ile Gly His Glu Asp 
785                 790                 795                 800 


Asp Gly Trp Thr Thr Val Gly Ile Val Ile Ile Val Val Val Cys Cys 
                805                 810                 815     


Val Val Gly Thr Ser Leu Ile Trp Val Ile Val Ile Tyr His Met Arg 
            820                 825                 830         


Arg Lys Asn Glu Asp Tyr Ser Ile Thr Asn Thr Glu Glu Leu Asn Leu 
        835                 840                 845             


Pro Ala Asp Ile Pro Ser Tyr Leu Ser Ser Gln Gly Thr Leu Ser Glu 
    850                 855                 860                 


Pro Gln Glu Gly Tyr Ser Asn Ser Glu Ala Gly Ser His Gln Gln Leu 
865                 870                 875                 880 


Met Pro Pro Ala Asn Gly Tyr Ile His Lys Gly Thr Asp Gly Gly Thr 
                885                 890                 895     


Gly Thr Arg Val Ile Cys Ser Asp Cys Tyr Asp Asn Ala Asn Ile Tyr 
            900                 905                 910         


Ser Arg Thr Arg Glu Tyr Cys Pro Tyr Thr Tyr Ile Ala Glu Glu Asp 
        915                 920                 925             


Val Leu Asp Gln Thr Leu Ser Ser Leu Met Val Gln Met Pro Lys Glu 
    930                 935                 940                 


Thr Tyr Leu Val His Pro Pro Gln Asp Thr Thr Ala Leu Glu Ser Leu 
945                 950                 955                 960 


Ile Pro Ser Ala Asn Arg Glu Pro Ser Ala Phe Pro Thr Asn His Glu 
                965                 970                 975     


Arg Ile Ser Glu Lys Lys Leu Pro Ser Thr Gln Met Ser Gly Glu Thr 
            980                 985                 990         


Leu Gln Arg Pro Val Trp Asn Ile  Asn Arg Glu Leu Gly  Leu Pro His 
        995                 1000                 1005             


Pro Pro  Phe Ser Gln Gln Pro  Val His Glu Ser Pro  Gln Leu His 
    1010                 1015                 1020             


Gln Asn  Glu Gly Leu Ala Gly  Arg Glu Pro Asp Cys  Ser Ala Ser 
    1025                 1030                 1035             


Ser Met  Ser Cys His Arg Leu  Gln Asp His Ala Phe  Asp Phe Ser 
    1040                 1045                 1050             


Arg Thr  Arg Asn Ile Gln Asp  Gly Ser Glu Gly Thr  
    1055                 1060                 1065 


<210>  103
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  104
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  105
<211>  1960
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Gln Gln Ala Ala Asp Lys Tyr Leu Tyr Val Asp Lys Asn Phe 
1               5                   10                  15      


Ile Asn Asn Pro Leu Ala Gln Ala Asp Trp Ala Ala Lys Lys Leu Val 
            20                  25                  30          


Trp Val Pro Ser Asp Lys Ser Gly Phe Glu Pro Ala Ser Leu Lys Glu 
        35                  40                  45              


Glu Val Gly Glu Glu Ala Ile Val Glu Leu Val Glu Asn Gly Lys Lys 
    50                  55                  60                  


Val Lys Val Asn Lys Asp Asp Ile Gln Lys Met Asn Pro Pro Lys Phe 
65                  70                  75                  80  


Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu Asn Glu Ala Ser 
                85                  90                  95      


Val Leu His Asn Leu Lys Glu Arg Tyr Tyr Ser Gly Leu Ile Tyr Thr 
            100                 105                 110         


Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr Lys Asn Leu Pro 
        115                 120                 125             


Ile Tyr Ser Glu Glu Ile Val Glu Met Tyr Lys Gly Lys Lys Arg His 
    130                 135                 140                 


Glu Met Pro Pro His Ile Tyr Ala Ile Thr Asp Thr Ala Tyr Arg Ser 
145                 150                 155                 160 


Met Met Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys Thr Gly Glu Ser 
                165                 170                 175     


Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile Gln Tyr Leu Ala 
            180                 185                 190         


Tyr Val Ala Ser Ser His Lys Ser Lys Lys Asp Gln Gly Glu Leu Glu 
        195                 200                 205             


Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala 
    210                 215                 220                 


Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg 
225                 230                 235                 240 


Ile Asn Phe Asp Val Asn Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr 
                245                 250                 255     


Tyr Leu Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Lys Glu Glu Arg 
            260                 265                 270         


Thr Phe His Ile Phe Tyr Tyr Leu Leu Ser Gly Ala Gly Glu His Leu 
        275                 280                 285             


Lys Thr Asp Leu Leu Leu Glu Pro Tyr Asn Lys Tyr Arg Phe Leu Ser 
    290                 295                 300                 


Asn Gly His Val Thr Ile Pro Gly Gln Gln Asp Lys Asp Met Phe Gln 
305                 310                 315                 320 


Glu Thr Met Glu Ala Met Arg Ile Met Gly Ile Pro Glu Glu Glu Gln 
                325                 330                 335     


Met Gly Leu Leu Arg Val Ile Ser Gly Val Leu Gln Leu Gly Asn Ile 
            340                 345                 350         


Val Phe Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn 
        355                 360                 365             


Thr Ala Ala Gln Lys Val Ser His Leu Leu Gly Ile Asn Val Thr Asp 
    370                 375                 380                 


Phe Thr Arg Gly Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Tyr 
385                 390                 395                 400 


Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Ile Glu Ala 
                405                 410                 415     


Leu Ala Lys Ala Thr Tyr Glu Arg Met Phe Arg Trp Leu Val Leu Arg 
            420                 425                 430         


Ile Asn Lys Ala Leu Asp Lys Thr Lys Arg Gln Gly Ala Ser Phe Ile 
        435                 440                 445             


Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Asp Leu Asn Ser Phe 
    450                 455                 460                 


Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe 
465                 470                 475                 480 


Asn His Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly 
                485                 490                 495     


Ile Glu Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile 
            500                 505                 510         


Asp Leu Ile Glu Lys Pro Ala Gly Pro Pro Gly Ile Leu Ala Leu Leu 
        515                 520                 525             


Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu 
    530                 535                 540                 


Lys Val Met Gln Glu Gln Gly Thr His Pro Lys Phe Gln Lys Pro Lys 
545                 550                 555                 560 


Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile Ile His Tyr Ala Gly Lys 
                565                 570                 575     


Val Asp Tyr Lys Ala Asp Glu Trp Leu Met Lys Asn Met Asp Pro Leu 
            580                 585                 590         


Asn Asp Asn Ile Ala Thr Leu Leu His Gln Ser Ser Asp Lys Phe Val 
        595                 600                 605             


Ser Glu Leu Trp Lys Asp Val Asp Arg Ile Ile Gly Leu Asp Gln Val 
    610                 615                 620                 


Ala Gly Met Ser Glu Thr Ala Leu Pro Gly Ala Phe Lys Thr Arg Lys 
625                 630                 635                 640 


Gly Met Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Ala Lys 
                645                 650                 655     


Leu Met Ala Thr Leu Arg Asn Thr Asn Pro Asn Phe Val Arg Cys Ile 
            660                 665                 670         


Ile Pro Asn His Glu Lys Lys Ala Gly Lys Leu Asp Pro His Leu Val 
        675                 680                 685             


Leu Asp Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys 
    690                 695                 700                 


Arg Gln Gly Phe Pro Asn Arg Val Val Phe Gln Glu Phe Arg Gln Arg 
705                 710                 715                 720 


Tyr Glu Ile Leu Thr Pro Asn Ser Ile Pro Lys Gly Phe Met Asp Gly 
                725                 730                 735     


Lys Gln Ala Cys Val Leu Met Ile Lys Ala Leu Glu Leu Asp Ser Asn 
            740                 745                 750         


Leu Tyr Arg Ile Gly Gln Ser Lys Val Phe Phe Arg Ala Gly Val Leu 
        755                 760                 765             


Ala His Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Ile 
    770                 775                 780                 


Gly Phe Gln Ala Cys Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala 
785                 790                 795                 800 


Lys Arg Gln Gln Gln Leu Thr Ala Met Lys Val Leu Gln Arg Asn Cys 
                805                 810                 815     


Ala Ala Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr 
            820                 825                 830         


Lys Val Lys Pro Leu Leu Gln Val Ser Arg Gln Glu Glu Glu Met Met 
        835                 840                 845             


Ala Lys Glu Glu Glu Leu Val Lys Val Arg Glu Lys Gln Leu Ala Ala 
    850                 855                 860                 


Glu Asn Arg Leu Thr Glu Met Glu Thr Leu Gln Ser Gln Leu Met Ala 
865                 870                 875                 880 


Glu Lys Leu Gln Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Cys 
                885                 890                 895     


Ala Glu Ala Glu Glu Leu Arg Ala Arg Leu Thr Ala Lys Lys Gln Glu 
            900                 905                 910         


Leu Glu Glu Ile Cys His Asp Leu Glu Ala Arg Val Glu Glu Glu Glu 
        915                 920                 925             


Glu Arg Cys Gln His Leu Gln Ala Glu Lys Lys Lys Met Gln Gln Asn 
    930                 935                 940                 


Ile Gln Glu Leu Glu Glu Gln Leu Glu Glu Glu Glu Ser Ala Arg Gln 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Val Thr Thr Glu Ala Lys Leu Lys Lys Leu 
                965                 970                 975     


Glu Glu Glu Gln Ile Ile Leu Glu Asp Gln Asn Cys Lys Leu Ala Lys 
            980                 985                 990         


Glu Lys Lys Leu Leu Glu Asp Arg  Ile Ala Glu Phe Thr  Thr Asn Leu 
        995                 1000                 1005             


Thr Glu  Glu Glu Glu Lys Ser  Lys Ser Leu Ala Lys  Leu Lys Asn 
    1010                 1015                 1020             


Lys His  Glu Ala Met Ile Thr  Asp Leu Glu Glu Arg  Leu Arg Arg 
    1025                 1030                 1035             


Glu Glu  Lys Gln Arg Gln Glu  Leu Glu Lys Thr Arg  Arg Lys Leu 
    1040                 1045                 1050             


Glu Gly  Asp Ser Thr Asp Leu  Ser Asp Gln Ile Ala  Glu Leu Gln 
    1055                 1060                 1065             


Ala Gln  Ile Ala Glu Leu Lys  Met Gln Leu Ala Lys  Lys Glu Glu 
    1070                 1075                 1080             


Glu Leu  Gln Ala Ala Leu Ala  Arg Val Glu Glu Glu  Ala Ala Gln 
    1085                 1090                 1095             


Lys Asn  Met Ala Leu Lys Lys  Ile Arg Glu Leu Glu  Ser Gln Ile 
    1100                 1105                 1110             


Ser Glu  Leu Gln Glu Asp Leu  Glu Ser Glu Arg Ala  Ser Arg Asn 
    1115                 1120                 1125             


Lys Ala  Glu Lys Gln Lys Arg  Asp Leu Gly Glu Glu  Leu Glu Ala 
    1130                 1135                 1140             


Leu Lys  Thr Glu Leu Glu Asp  Thr Leu Asp Ser Thr  Ala Ala Gln 
    1145                 1150                 1155             


Gln Glu  Leu Arg Ser Lys Arg  Glu Gln Glu Val Asn  Ile Leu Lys 
    1160                 1165                 1170             


Lys Thr  Leu Glu Glu Glu Ala  Lys Thr His Glu Ala  Gln Ile Gln 
    1175                 1180                 1185             


Glu Met  Arg Gln Lys His Ser  Gln Ala Val Glu Glu  Leu Ala Glu 
    1190                 1195                 1200             


Gln Leu  Glu Gln Thr Lys Arg  Val Lys Ala Asn Leu  Glu Lys Ala 
    1205                 1210                 1215             


Lys Gln  Thr Leu Glu Asn Glu  Arg Gly Glu Leu Ala  Asn Glu Val 
    1220                 1225                 1230             


Lys Val  Leu Leu Gln Gly Lys  Gly Asp Ser Glu His  Lys Arg Lys 
    1235                 1240                 1245             


Lys Val  Glu Ala Gln Leu Gln  Glu Leu Gln Val Lys  Phe Asn Glu 
    1250                 1255                 1260             


Gly Glu  Arg Val Arg Thr Glu  Leu Ala Asp Lys Val  Thr Lys Leu 
    1265                 1270                 1275             


Gln Val  Glu Leu Asp Asn Val  Thr Gly Leu Leu Ser  Gln Ser Asp 
    1280                 1285                 1290             


Ser Lys  Ser Ser Lys Leu Thr  Lys Asp Phe Ser Ala  Leu Glu Ser 
    1295                 1300                 1305             


Gln Leu  Gln Asp Thr Gln Glu  Leu Leu Gln Glu Glu  Asn Arg Gln 
    1310                 1315                 1320             


Lys Leu  Ser Leu Ser Thr Lys  Leu Lys Gln Val Glu  Asp Glu Lys 
    1325                 1330                 1335             


Asn Ser  Phe Arg Glu Gln Leu  Glu Glu Glu Glu Glu  Ala Lys His 
    1340                 1345                 1350             


Asn Leu  Glu Lys Gln Ile Ala  Thr Leu His Ala Gln  Val Ala Asp 
    1355                 1360                 1365             


Met Lys  Lys Lys Met Glu Asp  Ser Val Gly Cys Leu  Glu Thr Ala 
    1370                 1375                 1380             


Glu Glu  Val Lys Arg Lys Leu  Gln Lys Asp Leu Glu  Gly Leu Ser 
    1385                 1390                 1395             


Gln Arg  His Glu Glu Lys Val  Ala Ala Tyr Asp Lys  Leu Glu Lys 
    1400                 1405                 1410             


Thr Lys  Thr Arg Leu Gln Gln  Glu Leu Asp Asp Leu  Leu Val Asp 
    1415                 1420                 1425             


Leu Asp  His Gln Arg Gln Ser  Ala Cys Asn Leu Glu  Lys Lys Gln 
    1430                 1435                 1440             


Lys Lys  Phe Asp Gln Leu Leu  Ala Glu Glu Lys Thr  Ile Ser Ala 
    1445                 1450                 1455             


Lys Tyr  Ala Glu Glu Arg Asp  Arg Ala Glu Ala Glu  Ala Arg Glu 
    1460                 1465                 1470             


Lys Glu  Thr Lys Ala Leu Ser  Leu Ala Arg Ala Leu  Glu Glu Ala 
    1475                 1480                 1485             


Met Glu  Gln Lys Ala Glu Leu  Glu Arg Leu Asn Lys  Gln Phe Arg 
    1490                 1495                 1500             


Thr Glu  Met Glu Asp Leu Met  Ser Ser Lys Asp Asp  Val Gly Lys 
    1505                 1510                 1515             


Ser Val  His Glu Leu Glu Lys  Ser Lys Arg Ala Leu  Glu Gln Gln 
    1520                 1525                 1530             


Val Glu  Glu Met Lys Thr Gln  Leu Glu Glu Leu Glu  Asp Glu Leu 
    1535                 1540                 1545             


Gln Ala  Thr Glu Asp Ala Lys  Leu Arg Leu Glu Val  Asn Leu Gln 
    1550                 1555                 1560             


Ala Met  Lys Ala Gln Phe Glu  Arg Asp Leu Gln Gly  Arg Asp Glu 
    1565                 1570                 1575             


Gln Ser  Glu Glu Lys Lys Lys  Gln Leu Val Arg Gln  Val Arg Glu 
    1580                 1585                 1590             


Met Glu  Ala Glu Leu Glu Asp  Glu Arg Lys Gln Arg  Ser Met Ala 
    1595                 1600                 1605             


Val Ala  Ala Arg Lys Lys Leu  Glu Met Asp Leu Lys  Asp Leu Glu 
    1610                 1615                 1620             


Ala His  Ile Asp Ser Ala Asn  Lys Asn Arg Asp Glu  Ala Ile Lys 
    1625                 1630                 1635             


Gln Leu  Arg Lys Leu Gln Ala  Gln Met Lys Asp Cys  Met Arg Glu 
    1640                 1645                 1650             


Leu Asp  Asp Thr Arg Ala Ser  Arg Glu Glu Ile Leu  Ala Gln Ala 
    1655                 1660                 1665             


Lys Glu  Asn Glu Lys Lys Leu  Lys Ser Met Glu Ala  Glu Met Ile 
    1670                 1675                 1680             


Gln Leu  Gln Glu Glu Leu Ala  Ala Ala Glu Arg Ala  Lys Arg Gln 
    1685                 1690                 1695             


Ala Gln  Gln Glu Arg Asp Glu  Leu Ala Asp Glu Ile  Ala Asn Ser 
    1700                 1705                 1710             


Ser Gly  Lys Gly Ala Leu Ala  Leu Glu Glu Lys Arg  Arg Leu Glu 
    1715                 1720                 1725             


Ala Arg  Ile Ala Gln Leu Glu  Glu Glu Leu Glu Glu  Glu Gln Gly 
    1730                 1735                 1740             


Asn Thr  Glu Leu Ile Asn Asp  Arg Leu Lys Lys Ala  Asn Leu Gln 
    1745                 1750                 1755             


Ile Asp  Gln Ile Asn Thr Asp  Leu Asn Leu Glu Arg  Ser His Ala 
    1760                 1765                 1770             


Gln Lys  Asn Glu Asn Ala Arg  Gln Gln Leu Glu Arg  Gln Asn Lys 
    1775                 1780                 1785             


Glu Leu  Lys Val Lys Leu Gln  Glu Met Glu Gly Thr  Val Lys Ser 
    1790                 1795                 1800             


Lys Tyr  Lys Ala Ser Ile Thr  Ala Leu Glu Ala Lys  Ile Ala Gln 
    1805                 1810                 1815             


Leu Glu  Glu Gln Leu Asp Asn  Glu Thr Lys Glu Arg  Gln Ala Ala 
    1820                 1825                 1830             


Cys Lys  Gln Val Arg Arg Thr  Glu Lys Lys Leu Lys  Asp Val Leu 
    1835                 1840                 1845             


Leu Gln  Val Asp Asp Glu Arg  Arg Asn Ala Glu Gln  Tyr Lys Asp 
    1850                 1855                 1860             


Gln Ala  Asp Lys Ala Ser Thr  Arg Leu Lys Gln Leu  Lys Arg Gln 
    1865                 1870                 1875             


Leu Glu  Glu Ala Glu Glu Glu  Ala Gln Arg Ala Asn  Ala Ser Arg 
    1880                 1885                 1890             


Arg Lys  Leu Gln Arg Glu Leu  Glu Asp Ala Thr Glu  Thr Ala Asp 
    1895                 1900                 1905             


Ala Met  Asn Arg Glu Val Ser  Ser Leu Lys Asn Lys  Leu Arg Arg 
    1910                 1915                 1920             


Gly Asp  Leu Pro Phe Val Val  Pro Arg Arg Met Ala  Arg Lys Gly 
    1925                 1930                 1935             


Ala Gly  Asp Gly Ser Asp Glu  Glu Val Asp Gly Lys  Ala Asp Gly 
    1940                 1945                 1950             


Ala Glu  Ala Lys Pro Ala Glu  
    1955                 1960 


<210>  106
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro 
        115 


<210>  107
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  108
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210>  109
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  110
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Asn Gly Gln Leu Asp Leu Ser Gly Lys Leu Ile Ile Lys Ala Gln 
1               5                   10                  15      


Leu Gly Glu Asp Ile Arg Arg Ile Pro Ile His Asn Glu Asp Ile Thr 
            20                  25                  30          


Tyr Asp Glu Leu Val Leu Met Met Gln Arg Val Phe Arg Gly Lys Leu 
        35                  40                  45              


Leu Ser Asn Asp Glu Val Thr Ile Lys Tyr Lys Asp Glu Asp Gly Asp 
    50                  55                  60                  


Leu Ile Thr Ile Phe Asp Ser Ser Asp Leu Ser Phe Ala Ile Gln Cys 
65                  70                  75                  80  


Ser Arg Ile Leu Lys Leu Thr Leu Phe Val Asn Gly Gln Pro Arg Pro 
                85                  90                  95      


Leu Glu Ser Ser Gln Val Lys Tyr Leu Arg Arg Glu Leu Ile Glu Leu 
            100                 105                 110         


Arg Asn Lys Val Asn Arg Leu Leu Asp Ser Leu Glu Pro Pro Gly Glu 
        115                 120                 125             


Pro Gly Pro Ser Thr Asn Ile Pro Glu Asn Asp Thr Val Asp Gly Arg 
    130                 135                 140                 


Glu Glu Lys Ser Ala Ser Asp Ser Ser Gly Lys Gln Ser Thr Gln Val 
145                 150                 155                 160 


Met Ala Ala Ser Met Ser Ala Phe Asp Pro Leu Lys Asn Gln Asp Glu 
                165                 170                 175     


Ile Asn Lys Asn Val Met Ser Ala Phe Gly Leu Thr Asp Asp Gln Val 
            180                 185                 190         


Ser Gly Pro Pro Ser Ala Pro Ala Glu Asp Arg Ser Gly Thr Pro Asp 
        195                 200                 205             


Ser Ile Ala Ser Ser Ser Ser Ala Ala His Pro Pro Gly Val Gln Pro 
    210                 215                 220                 


Gln Gln Pro Pro Tyr Thr Gly Ala Gln Thr Gln Ala Gly Gln Ile Glu 
225                 230                 235                 240 


Gly Gln Met Tyr Gln Gln Tyr Gln Gln Gln Ala Gly Tyr Gly Ala Gln 
                245                 250                 255     


Gln Pro Gln Ala Pro Pro Gln Gln Pro Gln Gln Tyr Gly Ile Gln Tyr 
            260                 265                 270         


Ser Ala Ser Tyr Ser Gln Gln Thr Gly Pro Gln Gln Pro Gln Gln Phe 
        275                 280                 285             


Gln Gly Tyr Gly Gln Gln Pro Thr Ser Gln Ala Pro Ala Pro Ala Phe 
    290                 295                 300                 


Ser Gly Gln Pro Gln Gln Leu Pro Ala Gln Pro Pro Gln Gln Tyr Gln 
305                 310                 315                 320 


Ala Ser Asn Tyr Pro Ala Gln Thr Tyr Thr Ala Gln Thr Ser Gln Pro 
                325                 330                 335     


Thr Asn Tyr Thr Val Ala Pro Ala Ser Gln Pro Gly Met Ala Pro Ser 
            340                 345                 350         


Gln Pro Gly Ala Tyr Gln Pro Arg Pro Gly Phe Thr Ser Leu Pro Gly 
        355                 360                 365             


Ser Thr Met Thr Pro Pro Pro Ser Gly Pro Asn Pro Tyr Ala Arg Asn 
    370                 375                 380                 


Arg Pro Pro Phe Gly Gln Gly Tyr Thr Gln Pro Gly Pro Gly Tyr Arg 
385                 390                 395                 400 


<210>  111
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  112
<211>  2391
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser Lys Gly Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu Asp Arg Asp 
    50                  55                  60                  


His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr Cys Lys Ala 
                85                  90                  95      


Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln Glu Glu Glu 
            100                 105                 110         


Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly His Lys Ser Gly 
        115                 120                 125             


Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly Tyr Ser Ser 
    130                 135                 140                 


Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly Ser Asn Ser Arg 
145                 150                 155                 160 


Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly Asn Gln Glu Gly 
                165                 170                 175     


Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His Ser Trp Ser Gly 
            180                 185                 190         


Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu Arg Glu Arg Ile 
        195                 200                 205             


Asn Lys Ser His Ile Ser Pro Ser Arg Glu Ser Gly Glu Glu Tyr Glu 
    210                 215                 220                 


Ser Gly Ser Gly Ser Asn Ser Trp Glu Arg Lys Gly His Gly Gly Leu 
225                 230                 235                 240 


Ser Cys Gly Leu Glu Thr Ser Gly His Glu Ser Asn Ser Thr Gln Ser 
                245                 250                 255     


Arg Ile Arg Glu Gln Lys Leu Gly Ser Ser Cys Ser Gly Ser Gly Asp 
            260                 265                 270         


Ser Gly Arg Arg Ser His Ala Cys Gly Tyr Ser Asn Ser Ser Gly Cys 
        275                 280                 285             


Gly Arg Pro Gln Asn Ala Ser Ser Ser Cys Gln Ser His Arg Phe Gly 
    290                 295                 300                 


Gly Gln Gly Asn Gln Phe Ser Tyr Ile Gln Ser Gly Cys Gln Ser Gly 
305                 310                 315                 320 


Ile Lys Gly Gly Gln Gly His Gly Cys Val Ser Gly Gly Gln Pro Ser 
                325                 330                 335     


Gly Cys Gly Gln Pro Glu Ser Asn Pro Cys Ser Gln Ser Tyr Ser Gln 
            340                 345                 350         


Arg Gly Tyr Gly Ala Arg Glu Asn Gly Gln Pro Gln Asn Cys Gly Gly 
        355                 360                 365             


Gln Trp Arg Thr Gly Ser Ser Gln Ser Ser Cys Cys Gly Gln Tyr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gln Ser Cys Ser Asn Gly Gln His Glu Tyr Gly Ser 
385                 390                 395                 400 


Cys Gly Arg Phe Ser Asn Ser Ser Ser Ser Asn Glu Phe Ser Lys Cys 
                405                 410                 415     


Asp Gln Tyr Gly Ser Gly Ser Ser Gln Ser Thr Ser Phe Glu Gln His 
            420                 425                 430         


Gly Thr Gly Leu Ser Gln Ser Ser Gly Phe Glu Gln His Val Cys Gly 
        435                 440                 445             


Ser Gly Gln Thr Cys Gly Gln His Glu Ser Thr Ser Ser Gln Ser Leu 
    450                 455                 460                 


Gly Tyr Asp Gln His Gly Ser Ser Ser Gly Lys Thr Ser Gly Phe Gly 
465                 470                 475                 480 


Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln Cys Gly 
                485                 490                 495     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Val Ser 
            500                 505                 510         


Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Val Ser Gly Gln Ser 
        515                 520                 525             


Ser Gly Phe Gly Gln His Glu Ser Arg Ser Arg Gln Ser Ser Tyr Gly 
    530                 535                 540                 


Gln His Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly Gln Tyr Gly 
545                 550                 555                 560 


Ser Arg Glu Thr Ser Gly Phe Gly Gln His Gly Leu Gly Ser Gly Gln 
                565                 570                 575     


Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            580                 585                 590         


Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln 
        595                 600                 605             


His Glu Ser Arg Ser Gly Gln Ser Ser Tyr Gly Gln His Ser Ser Gly 
    610                 615                 620                 


Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Arg Gln Thr Ser 
625                 630                 635                 640 


Gly Phe Gly Gln His Gly Ser Gly Ser Ser Gln Ser Thr Gly Phe Gly 
                645                 650                 655     


Gln Tyr Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Val 
            660                 665                 670         


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser 
        675                 680                 685             


Gly His Ser Ser Tyr Gly Gln His Gly Phe Gly Ser Ser Gln Ser Ser 
    690                 695                 700                 


Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln Thr Ser Gly Phe Gly 
705                 710                 715                 720 


Gln His Glu Leu Ser Ser Gly Gln Ser Ser Ser Phe Gly Gln His Gly 
                725                 730                 735     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Gly Ser 
            740                 745                 750         


Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser Gly Gln Ser 
        755                 760                 765             


Ser Tyr Gly Gln His Ser Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly 
    770                 775                 780                 


Gln His Gly Ser Arg Gln Thr Ser Gly Phe Gly Gln His Gly Ser Gly 
785                 790                 795                 800 


Ser Ser Gln Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln 
                805                 810                 815     


Ser Ala Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            820                 825                 830         


Phe Gly Gln His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly Gln His 
        835                 840                 845             


Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser 
    850                 855                 860                 


Ser Gly Gln Thr Ser Gly Phe Gly Gln His Arg Ser Ser Ser Gly Gln 
865                 870                 875                 880 


Tyr Ser Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
                885                 890                 895     


Phe Gly Gln His Gly Thr Gly Ser Gly Gln Tyr Ser Gly Phe Gly Gln 
            900                 905                 910         


His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly Gln His Gly Ser Gly 
        915                 920                 925             


Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln 
    930                 935                 940                 


Thr Phe Gly Phe Gly Gln His Arg Ser Gly Ser Gly Gln Ser Ser Gly 
945                 950                 955                 960 


Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln 
                965                 970                 975     


His Glu Ser Gly Ser Gly Lys Ser Ser Gly Phe Gly Gln His Glu Ser 
            980                 985                 990         


Arg Ser Ser Gln Ser Asn Tyr Gly  Gln His Gly Ser Gly  Ser Ser Gln 
        995                 1000                 1005             


Ser Ser  Gly Tyr Gly Gln His  Gly Ser Ser Ser Gly  Gln Thr Thr 
    1010                 1015                 1020             


Gly Phe  Gly Gln His Arg Ser  Ser Ser Gly Gln Tyr  Ser Gly Phe 
    1025                 1030                 1035             


Gly Gln  His Gly Ser Gly Ser  Asp Gln Ser Ser Gly  Phe Gly Gln 
    1040                 1045                 1050             


His Gly  Thr Gly Ser Gly Gln  Ser Ser Gly Phe Gly  Gln Tyr Glu 
    1055                 1060                 1065             


Ser Arg  Ser Arg Gln Ser Ser  Tyr Gly Gln His Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gln  Ser Ser Gly Tyr Gly  Gln His Gly Ser Asn  Ser Gly Gln 
    1085                 1090                 1095             


Thr Ser  Gly Phe Gly Gln His  Arg Pro Gly Ser Gly  Gln Ser Ser 
    1100                 1105                 1110             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Ser Gly Phe 
    1115                 1120                 1125             


Gly Gln  His Gly Ser Gly Thr  Gly Lys Ser Ser Gly  Phe Ala Gln 
    1130                 1135                 1140             


His Glu  Tyr Arg Ser Gly Gln  Ser Ser Tyr Gly Gln  His Gly Thr 
    1145                 1150                 1155             


Gly Ser  Ser Gln Ser Ser Gly  Cys Gly Gln His Glu  Ser Gly Ser 
    1160                 1165                 1170             


Gly Pro  Thr Thr Ser Phe Gly  Gln His Val Ser Gly  Ser Asp Asn 
    1175                 1180                 1185             


Phe Ser  Ser Ser Gly Gln His  Ile Ser Asp Ser Gly  Gln Ser Thr 
    1190                 1195                 1200             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Thr Gly Leu 
    1205                 1210                 1215             


Gly Gln  Gly Glu Ser Gln Gln  Val Glu Ser Gly Ser  Thr Val His 
    1220                 1225                 1230             


Gly Arg  Gln Glu Thr Thr His  Gly Gln Thr Ile Asn  Thr Thr Arg 
    1235                 1240                 1245             


His Ser  Gln Ser Gly Gln Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1250                 1255                 1260             


Val Thr  Arg Arg Arg Arg Ser  Ser Gln Ser Glu Asn  Ser Asp Ser 
    1265                 1270                 1275             


Glu Val  His Ser Lys Val Ser  His Arg His Ser Glu  His Ile His 
    1280                 1285                 1290             


Thr Gln  Ala Gly Ser His Tyr  Pro Lys Ser Gly Ser  Thr Val Arg 
    1295                 1300                 1305             


Arg Arg  Gln Gly Thr Thr His  Gly Gln Arg Gly Asp  Thr Thr Arg 
    1310                 1315                 1320             


His Gly  His Ser Gly His Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1325                 1330                 1335             


Thr Ser  Gly Arg Gln Arg Phe  Ser His Ser Asp Ala  Thr Asp Ser 
    1340                 1345                 1350             


Glu Val  His Ser Gly Val Ser  His Arg Pro His Ser  Gln Glu Gln 
    1355                 1360                 1365             


Thr His  Ser Gln Ala Gly Ser  Gln His Gly Glu Ser  Glu Ser Thr 
    1370                 1375                 1380             


Val His  Glu Arg His Glu Thr  Thr Tyr Gly Gln Thr  Gly Glu Ala 
    1385                 1390                 1395             


Thr Gly  His Gly His Ser Gly  His Gly Gln Ser Thr  Gln Arg Gly 
    1400                 1405                 1410             


Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly His Ser  Glu Ser Ser 
    1415                 1420                 1425             


Asp Ser  Glu Val His Ser Gly  Gly Ser His Arg Pro  Gln Ser Gln 
    1430                 1435                 1440             


Glu Gln  Thr His Gly Gln Ala  Gly Ser Gln His Gly  Glu Ser Gly 
    1445                 1450                 1455             


Ser Thr  Val His Gly Arg His  Gly Thr Thr His Gly  Gln Thr Gly 
    1460                 1465                 1470             


Asp Thr  Thr Arg His Ala His  Tyr His His Gly Lys  Ser Thr Gln 
    1475                 1480                 1485             


Arg Gly  Ser Ser Thr Thr Gly  Arg Arg Gly Ser Gly  His Ser Glu 
    1490                 1495                 1500             


Ser Ser  Asp Ser Glu Val His  Ser Gly Gly Ser His  Thr His Ser 
    1505                 1510                 1515             


Gly His  Thr His Gly Gln Ser  Gly Ser Gln His Gly  Glu Ser Glu 
    1520                 1525                 1530             


Ser Ile  Ile His Asp Arg His  Arg Ile Thr His Gly  Gln Thr Gly 
    1535                 1540                 1545             


Asp Thr  Thr Arg His Ser Tyr  Ser Gly His Glu Gln  Thr Thr Gln 
    1550                 1555                 1560             


Thr Gly  Ser Arg Thr Thr Gly  Arg Gln Arg Thr Ser  His Ser Glu 
    1565                 1570                 1575             


Ser Thr  Asp Ser Glu Val His  Ser Gly Gly Ser His  Arg Pro His 
    1580                 1585                 1590             


Ser Arg  Glu His Thr Tyr Gly  Gln Ala Gly Ser Gln  His Glu Glu 
    1595                 1600                 1605             


Pro Glu  Phe Thr Val His Glu  Arg His Gly Thr Thr  His Gly Gln 
    1610                 1615                 1620             


Ile Gly  Asp Thr Thr Gly His  Ser His Ser Gly His  Gly Gln Ser 
    1625                 1630                 1635             


Thr Gln  Arg Gly Ser Arg Thr  Thr Gly Arg Gln Arg  Ser Ser His 
    1640                 1645                 1650             


Ser Glu  Ser Ser Asp Ser Glu  Val His Ser Gly Val  Ser His Thr 
    1655                 1660                 1665             


His Thr  Gly His Thr His Gly  Gln Ala Gly Ser Gln  His Gly Gln 
    1670                 1675                 1680             


Ser Glu  Ser Ile Val Pro Glu  Arg His Gly Thr Thr  His Gly Gln 
    1685                 1690                 1695             


Thr Gly  Asp Thr Thr Arg His  Ala His Tyr His His  Gly Leu Thr 
    1700                 1705                 1710             


Thr Gln  Thr Gly Ser Arg Thr  Thr Gly Arg Arg Gly  Ser Gly His 
    1715                 1720                 1725             


Ser Glu  Tyr Ser Asp Ser Glu  Gly Tyr Ser Gly Val  Ser His Thr 
    1730                 1735                 1740             


His Ser  Gly His Thr His Gly  Gln Ala Arg Ser Gln  His Gly Glu 
    1745                 1750                 1755             


Ser Glu  Ser Ile Val His Glu  Arg His Gly Thr Ile  His Gly Gln 
    1760                 1765                 1770             


Thr Gly  Asp Thr Thr Arg His  Ala His Ser Gly His  Gly Gln Ser 
    1775                 1780                 1785             


Thr Gln  Thr Gly Ser Arg Thr  Thr Gly Arg Arg Ser  Ser Gly His 
    1790                 1795                 1800             


Ser Glu  Tyr Ser Asp Ser Glu  Gly His Ser Gly Phe  Ser Gln Arg 
    1805                 1810                 1815             


Pro His  Ser Arg Gly His Thr  His Gly Gln Ala Gly  Ser Gln His 
    1820                 1825                 1830             


Gly Glu  Ser Glu Ser Ile Val  Asp Glu Arg His Gly  Thr Thr His 
    1835                 1840                 1845             


Gly Gln  Thr Gly Asp Thr Ser  Gly His Ser Gln Ser  Gly His Gly 
    1850                 1855                 1860             


Gln Ser  Thr Gln Ser Gly Ser  Ser Thr Thr Gly Arg  Arg Arg Ser 
    1865                 1870                 1875             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Gly Gly Ser 
    1880                 1885                 1890             


His Thr  His Ser Gly His Thr  His Ser Gln Ala Arg  Ser Gln His 
    1895                 1900                 1905             


Gly Glu  Ser Glu Ser Thr Val  His Lys Arg His Gln  Thr Thr His 
    1910                 1915                 1920             


Gly Gln  Thr Gly Asp Thr Thr  Glu His Gly His Pro  Ser His Gly 
    1925                 1930                 1935             


Gln Thr  Ile Gln Thr Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser 
    1940                 1945                 1950             


Gly His  Ser Glu Tyr Ser Asp  Ser Glu Gly Pro Ser  Gly Val Ser 
    1955                 1960                 1965             


His Thr  His Ser Gly His Thr  His Gly Gln Ala Gly  Ser His Tyr 
    1970                 1975                 1980             


Pro Glu  Ser Gly Ser Ser Val  His Glu Arg His Gly  Thr Thr His 
    1985                 1990                 1995             


Gly Gln  Thr Ala Asp Thr Thr  Arg His Gly His Ser  Gly His Gly 
    2000                 2005                 2010             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Thr Gly Arg  Arg Ala Ser 
    2015                 2020                 2025             


Gly His  Ser Glu Tyr Ser Asp  Ser Glu Gly His Ser  Gly Val Ser 
    2030                 2035                 2040             


His Thr  His Ser Gly His Ala  His Gly Gln Ala Gly  Ser Gln His 
    2045                 2050                 2055             


Gly Glu  Ser Gly Ser Ser Val  His Glu Arg His Gly  Thr Thr His 
    2060                 2065                 2070             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Ala His Ser  Gly His Gly 
    2075                 2080                 2085             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Ala Gly Arg  Arg Gly Ser 
    2090                 2095                 2100             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Gly Val Ser 
    2105                 2110                 2115             


His Thr  His Ser Gly His Thr  Tyr Gly Gln Ala Arg  Ser Gln His 
    2120                 2125                 2130             


Gly Glu  Ser Gly Ser Ala Ile  His Gly Arg Gln Gly  Thr Ile His 
    2135                 2140                 2145             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Gly Gln Ser  Gly His Gly 
    2150                 2155                 2160             


Gln Ser  Thr Gln Thr Gly Ser  Arg Thr Thr Gly Arg  Gln Arg Ser 
    2165                 2170                 2175             


Ser His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Glu Ala Ser 
    2180                 2185                 2190             


Pro Thr  His Ser Gly His Thr  His Ser Gln Ala Gly  Ser Arg His 
    2195                 2200                 2205             


Gly Gln  Ser Gly Ser Ser Gly  His Gly Arg Gln Gly  Thr Thr His 
    2210                 2215                 2220             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Ala His Tyr  Gly Tyr Gly 
    2225                 2230                 2235             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser 
    2240                 2245                 2250             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Trp Gly Ser 
    2255                 2260                 2265             


His Thr  His Ser Gly His Ile  Gln Gly Gln Ala Gly  Ser Gln Gln 
    2270                 2275                 2280             


Arg Gln  Pro Gly Ser Thr Val  His Gly Arg Leu Glu  Thr Thr His 
    2285                 2290                 2295             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Gly His Ser  Gly Tyr Gly 
    2300                 2305                 2310             


Gln Ser  Thr Gln Thr Gly Ser  Arg Ser Ser Arg Ala  Ser His Phe 
    2315                 2320                 2325             


Gln Ser  His Ser Ser Glu Arg  Gln Arg His Gly Ser  Ser Gln Val 
    2330                 2335                 2340             


Trp Lys  His Gly Ser Tyr Gly  Pro Ala Glu Tyr Asp  Tyr Gly His 
    2345                 2350                 2355             


Thr Gly  Tyr Gly Pro Ser Gly  Gly Ser Arg Lys Ser  Ile Ser Asn 
    2360                 2365                 2370             


Ser His  Leu Ser Trp Ser Thr  Asp Ser Thr Ala Asn  Lys Gln Leu 
    2375                 2380                 2385             


Ser Arg  His 
    2390     


<210>  113
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210>  114
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro 
            20                  25                  30          


Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser 
        35                  40                  45              


Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr 
    50                  55                  60                  


Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 
65                  70                  75                  80  


Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 
                85                  90                  95      


Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 
            100                 105                 110         


Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 
        115                 120                 125             


Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu 
    130                 135                 140                 


Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu 
145                 150                 155                 160 


Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu 
                165                 170                 175     


Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly 
            180                 185                 190         


Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala 
        195                 200                 205             


Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly 
    210                 215                 220                 


Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile 
225                 230                 235                 240 


Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu 
                245                 250                 255     


Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu 
            260                 265                 270         


Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln Lys Val Val Leu 
        275                 280                 285             


Ser Ser Gly Ser Gly Pro Gly Leu Asp Leu Pro Leu Val Leu Gly Leu 
    290                 295                 300                 


Pro Leu Gln Leu Lys Leu Ser Met Ser Arg Val Val Leu Ser Gln Gly 
305                 310                 315                 320 


Ser Lys Met Lys Ala Leu Ala Leu Pro Pro Leu Gly Leu Ala Pro Leu 
                325                 330                 335     


Leu Asn Leu Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu Gly Ala Leu 
            340                 345                 350         


Pro Gly Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala 
        355                 360                 365             


Gln Gly Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu 
    370                 375                 380                 


Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr Asp Ala 
385                 390                 395                 400 


Ser His 
        


<210>  115
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  116
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      


Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          


Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              


Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  


Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  


Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      


Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         


Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 


Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     


Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         


Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             


Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 


Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 


Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     


Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         


Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             


Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 


Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 


Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     


Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         


Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             


His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 


His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 


Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     


Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         


Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             


Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 


Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 


Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     


Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         


Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 


<210>  117
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Glu Val Lys Pro Pro Pro Gly Arg Pro Gln Pro Asp Ser Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
            20                  25                  30          


Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
        35                  40                  45              


Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
    50                  55                  60                  


Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
65                  70                  75                  80  


Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala Met Cys Ala Arg 
                85                  90                  95      


Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
            100                 105                 110         


Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
        115                 120                 125             


Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
    130                 135                 140                 


Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
145                 150                 155                 160 


Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp 
                165                 170                 175     


His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
            180                 185                 190         


Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys Gln Glu Met Gln 
        195                 200                 205             


Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met 
    210                 215                 220                 


Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                245                 250                 255     


Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly 
            260                 265                 270         


Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
        275                 280                 285             


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
    290                 295                 300                 


Gly Gly Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser 
                325                 330                 335     


Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly 
            340                 345                 350         


Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
    370                 375             


<210>  118
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  118

Glx Ile Val Leu Thr Glx Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glx Arg Ala Ala Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Gly Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glx 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Ser Lys Leu Glu Ile Lys 
            100                 105             


<210>  119
<211>  2789
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Pro Ser Asp Ala Lys Asp Ser Val Asn Gly Asp Leu Leu Leu Asn 
1               5                   10                  15      


Trp Thr Ser Leu Lys Asn Ile Leu Ser Gly Leu Asn Ala Ser Phe Pro 
            20                  25                  30          


Leu His Asn Asn Thr Gly Ser Ser Thr Val Thr Thr Ser Lys Ser Ile 
        35                  40                  45              


Lys Asp Pro Arg Leu Met Arg Arg Glu Glu Ser Met Gly Glu Gln Ser 
    50                  55                  60                  


Ser Thr Ala Gly Leu Asn Glu Val Leu Gln Phe Glu Lys Ser Ser Asp 
65                  70                  75                  80  


Asn Val Asn Ser Glu Ile Lys Ser Thr Pro Ser Asn Ser Ala Ser Ser 
                85                  90                  95      


Ser Glu Val Val Pro Gly Asp Cys Ala Val Leu Thr Asn Gly Leu Asp 
            100                 105                 110         


Thr Pro Cys Phe Lys Thr Ser Val Asn Asp Ser Gln Ser Trp Ala His 
        115                 120                 125             


Asn Met Gly Ser Glu Asp Tyr Asp Cys Ile Pro Pro Asn Lys Val Thr 
    130                 135                 140                 


Met Ala Gly Gln Cys Lys Asp Gln Gly Asn Phe Ser Phe Pro Ile Ser 
145                 150                 155                 160 


Val Ser Asn Val Val Ser Glu Val Glu Asn Gln Asn His Ser Glu Glu 
                165                 170                 175     


Lys Ala Gln Arg Ala Gln Gln Glu Ser Gly Asn Ala Tyr Thr Lys Glu 
            180                 185                 190         


Tyr Ser Ser His Ile Phe Gln Asp Ser Gln Ser Ser Asp Leu Lys Thr 
        195                 200                 205             


Ile Tyr Gln Thr Gly Cys Gln Thr Ser Thr Val Phe Pro Leu Lys Lys 
    210                 215                 220                 


Lys Val Ser Ile Asp Glu Tyr Leu Gln Asn Thr Gly Lys Met Lys Asn 
225                 230                 235                 240 


Phe Ala Asp Leu Glu Asp Ser Ser Lys His Glu Glu Lys Gln Thr Ser 
                245                 250                 255     


Trp Lys Glu Ile Asp Asn Asp Phe Thr Asn Glu Thr Lys Ile Ser Pro 
            260                 265                 270         


Ile Asp Asn Tyr Ile Val Leu His Gln Glu Tyr Lys Glu Ser Glu Ser 
        275                 280                 285             


His Asn Ser Phe Gly Lys Ser Cys Asp Lys Ile Leu Ile Thr Gln Glu 
    290                 295                 300                 


Leu Glu Ile Thr Lys Ser Ser Thr Ser Thr Ile Lys Asp Lys Asp Glu 
305                 310                 315                 320 


Leu Asp His Leu Ala Leu Glu Trp Gln Ile Thr Pro Ser Phe Glu Ser 
                325                 330                 335     


Leu Ser Gln Lys His Pro Gln His Ser Val Glu Tyr Glu Gly Asn Ile 
            340                 345                 350         


His Thr Ser Leu Ala Ile Ala Gln Lys Leu Met Glu Leu Lys Leu Gly 
        355                 360                 365             


Lys Ile Asn Gln Asn Tyr Ala Ser Ile Ile Thr Glu Ala Phe Pro Lys 
    370                 375                 380                 


Pro Lys Asp Ile Pro Gln Ala Lys Glu Met Phe Ile Asp Thr Val Ile 
385                 390                 395                 400 


Ser Ser Tyr Asn Ile Glu Thr Ala His Asp Ser Ser Asn Cys Ser Ile 
                405                 410                 415     


Thr Arg Glu His Ile Cys Val His Arg Lys Asn Glu Asn Glu Pro Val 
            420                 425                 430         


Ser Leu Glu Asn Ile Gln Arg Asp Tyr Lys Glu Thr Ala Tyr Val Glu 
        435                 440                 445             


Asp Arg Gly Gln Asp His Asn Leu Phe Cys Asn Ser Gln Leu Ser Asn 
    450                 455                 460                 


Asp Ile Trp Leu Asn Val Asn Phe Lys Lys Gln Thr Asp Arg Glu Asn 
465                 470                 475                 480 


Gln Asn Glu Ala Lys Glu Asn Ser Ala Ser Cys Val Glu Asn Asn Ile 
                485                 490                 495     


Glu Asn Ile Tyr Gly Asp Lys Lys Gln Asp Ser His Thr Asn Glu Asn 
            500                 505                 510         


Phe Ser Asn Ile Asp Glu Lys Glu Asp Lys Asn Tyr His Asn Ile Glu 
        515                 520                 525             


Ile Leu Ser Ser Glu Glu Phe Ser Thr Lys Phe Asn Leu Ile Cys Arg 
    530                 535                 540                 


Glu Asp Asn Ala Val Ser Ala Ala Thr Ala Leu Leu Glu Ser Glu Glu 
545                 550                 555                 560 


Asp Thr Ile Ser Ala Val Lys Gln Lys Asp Thr Glu Asn Thr Gly Arg 
                565                 570                 575     


Ser Val Glu His Leu Ala Ser Thr Thr Phe Pro Lys Thr Ala Ser Ser 
            580                 585                 590         


Ser Val Cys Val Ala Ser Asn Ala Ala Ile Gln Ile Ala Ser Ala Thr 
        595                 600                 605             


Met Pro Ala Leu Ser Leu Asn Asn Asp Asp His Gln Ile Tyr Gln Phe 
    610                 615                 620                 


Lys Glu Thr Cys Ser Ser Glu Ser Pro Asp Phe Gly Leu Leu Val Lys 
625                 630                 635                 640 


His Arg Val Ser Asp Cys Glu Ile Asp Thr Asp Lys Asn Lys Ser Gln 
                645                 650                 655     


Glu Ser Phe His Gln Ser Ile Asn Glu Asn Leu Val Leu Gln Ser Ile 
            660                 665                 670         


Glu Leu Glu Ser Glu Ile Glu Ile Glu Leu Glu Asp Cys Asp Asp Ala 
        675                 680                 685             


Phe Ile Phe Gln Gln Asp Thr His Ser His Glu Asn Met Leu Cys Glu 
    690                 695                 700                 


Glu Phe Val Thr Ser Tyr Lys Ala Leu Lys Ser Arg Ile Ser Trp Glu 
705                 710                 715                 720 


Gly Leu Leu Ala Leu Asp Asn Gly Glu Met Glu Val Leu Glu Ser Thr 
                725                 730                 735     


Thr Gly Arg Glu Asn Ser Asp Gln His Tyr Ser Lys Glu Ser Asn Tyr 
            740                 745                 750         


Phe Tyr Ser Ser Thr Gln Asn Asn Glu Thr Glu Leu Thr Ser Pro Ile 
        755                 760                 765             


Leu Leu Pro Asp Leu Gln Ile Lys Ile Thr Asn Ile Phe Arg Pro Gly 
    770                 775                 780                 


Phe Ser Pro Thr Ala Asp Ser Leu Ala Leu Lys Asp Ser Phe Cys Thr 
785                 790                 795                 800 


His Val Thr Glu Ala Thr Lys Pro Glu Ile Asn Lys Glu Asp Gly Glu 
                805                 810                 815     


Ile Leu Gly Phe Asp Ile Tyr Ser Gln Pro Phe Gly Glu Asn Ala Asp 
            820                 825                 830         


Tyr Pro Cys Glu Asp Lys Val Asp Asn Ile Arg Gln Glu Ser Gly Pro 
        835                 840                 845             


Val Ser Asn Ser Glu Ile Ser Leu Ser Phe Asp Leu Ser Arg Asn Thr 
    850                 855                 860                 


Asp Val Asn His Thr Ser Glu Asn Gln Asn Ser Glu Ser Leu Phe Thr 
865                 870                 875                 880 


Glu Pro Ser Asn Val Thr Thr Ile Asp Asp Gly Ser Arg Cys Phe Phe 
                885                 890                 895     


Thr Lys Ser Lys Thr Asp Tyr Asn Asp Thr Lys Asn Lys Lys Glu Val 
            900                 905                 910         


Glu Ser Arg Ile Ser Lys Arg Lys Leu His Ile Ser Ser Arg Asp Gln 
        915                 920                 925             


Asn Ile Pro His Lys Asp Leu Arg Arg His Lys Ile Tyr Gly Arg Lys 
    930                 935                 940                 


Arg Arg Leu Thr Ser Gln Asp Ser Ser Glu Cys Phe Ser Ser Leu Ser 
945                 950                 955                 960 


Gln Gly Arg Ile Lys Thr Phe Ser Gln Ser Glu Lys His Ile Lys Ser 
                965                 970                 975     


Val Leu Asn Ile Leu Ser Asp Glu Ala Ser Leu Cys Lys Ser Lys Cys 
            980                 985                 990         


Leu Ser Arg Lys Leu Asp Lys Ala  Val Val His Leu Lys  Lys Ala His 
        995                 1000                 1005             


Arg Arg  Val His Thr Ser Leu  Gln Leu Ile Thr Lys  Val Gly Glu 
    1010                 1015                 1020             


Glu Arg  Lys Gly Pro Leu Pro  Lys Ser Tyr Ala Ile  Ile Cys Asn 
    1025                 1030                 1035             


Asn Phe  Trp Glu Ser Cys Asp  Leu Gln Gly Tyr Ser  Ser Val Ser 
    1040                 1045                 1050             


Gln Arg  Lys Tyr Tyr Ser Thr  Lys His Phe Ser Ser  Lys Arg Lys 
    1055                 1060                 1065             


Tyr Asp  Lys Arg Arg Lys Lys  Arg Ala Pro Lys Ala  Asp Ile Ser 
    1070                 1075                 1080             


Lys Ser  Leu Thr His Val Ser  Lys His Lys Ser Tyr  Lys Thr Ser 
    1085                 1090                 1095             


Gly Glu  Lys Lys Cys Leu Ser  Arg Lys Ser Met Ala  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Ser His Pro Thr Thr  Ser His Met Gly Glu  Phe Cys Asn 
    1115                 1120                 1125             


Gln Glu  His Pro Glu Ser Gln  Leu Pro Val Ser Ser  Thr Ser Gln 
    1130                 1135                 1140             


Ser Thr  Ser Gln Ser Val Tyr  Tyr Asn Ser Ser Val  Ser Asn Pro 
    1145                 1150                 1155             


Ser Leu  Ser Glu Glu His Gln  Pro Phe Ser Gly Lys  Thr Ala Tyr 
    1160                 1165                 1170             


Leu Phe  Ser Pro Asp His Ser  Asp Glu Lys Leu Ile  Glu Lys Glu 
    1175                 1180                 1185             


Asn Gln  Ile Asp Thr Ala Phe  Leu Ser Ser Thr Ser  Lys Tyr Glu 
    1190                 1195                 1200             


Lys Leu  Glu Lys His Ser Ala  Asn His Asn Val Lys  Asp Ala Thr 
    1205                 1210                 1215             


Lys Glu  Asn Ser Cys Asp Ala  Asn Glu Val Ile Asn  Glu Ser Asn 
    1220                 1225                 1230             


Ser Val  Ser Leu Ser Cys Ile  Lys Glu Asn Ile Asn  Ser Ser Thr 
    1235                 1240                 1245             


Gly Asn  Asp Cys Asp Ala Thr  Cys Ile Gly His Thr  Lys Ala Lys 
    1250                 1255                 1260             


Thr Asp  Val Leu Ile Ser Val  Leu Asp Ser Asn Val  Lys His Phe 
    1265                 1270                 1275             


Leu Asn  Asp Leu Tyr Gln Gln  Gly Asn Leu Ile Leu  Ser Asp Cys 
    1280                 1285                 1290             


Lys Arg  Asn Leu Glu Val Lys  Trp Thr Asp Pro Ile  Glu Arg Pro 
    1295                 1300                 1305             


Lys Gln  Asn Ile Ile Thr Gly  Asn Phe Leu Met Gly  Pro Leu Asn 
    1310                 1315                 1320             


Leu Thr  Leu Ile Ala Ser Lys  Lys Tyr Ser Ile Pro  Gln Leu Ser 
    1325                 1330                 1335             


Ala Ala  Ala Val Thr Asp Ser  Glu Gly Glu Ser Ser  Lys Ser Tyr 
    1340                 1345                 1350             


Leu Asp  Lys Gln Arg Ile Leu  Thr Val Asp Ser Phe  Ala Ala Ser 
    1355                 1360                 1365             


Ser Thr  Val Pro His Cys Glu  Gln Ser Cys Arg Glu  Lys Glu Leu 
    1370                 1375                 1380             


Leu Lys  Thr Glu Gln Cys Ser  Ser Gly Asn Cys Leu  His Thr Asp 
    1385                 1390                 1395             


Gly Asn  Glu Thr Asn Val Thr  Glu Asn Tyr Glu Leu  Asp Val Ala 
    1400                 1405                 1410             


Ser Gly  Thr Glu Glu Asp Lys  Ser Tyr Gly Glu Asn  Ile Val Glu 
    1415                 1420                 1425             


Leu Ser  Ser Ser Asp Ser Ser  Leu Leu Leu Lys Asp  Asn Val Lys 
    1430                 1435                 1440             


Gly Ser  Ser Ser Glu Thr Cys  Ile Val Lys Lys Asp  Thr Glu Asp 
    1445                 1450                 1455             


Arg Ile  Thr Trp Lys Val Lys  Gln Ala Glu Lys Ala  Lys Asp Ser 
    1460                 1465                 1470             


Val Tyr  Lys Arg Ser Met Thr  Glu Gly Ser Thr Val  Asn Thr Glu 
    1475                 1480                 1485             


Tyr Lys  Asn Gln Lys Asn Gln  Ile Ser Glu Glu Ser  Cys Leu Asn 
    1490                 1495                 1500             


Glu Lys  Ile Ile Thr Thr Asn  Leu Ile Asp Ser His  Leu Ser Thr 
    1505                 1510                 1515             


Lys Asn  Thr Thr Thr Glu Ser  Val Pro Leu Lys Asn  Thr Val Ser 
    1520                 1525                 1530             


Asn Pro  Leu Asn Lys Arg Glu  Lys Lys Gly Glu Ile  Lys Val Ser 
    1535                 1540                 1545             


Lys Asp  Ser Gln Ser Asp Leu  Thr Leu His Ser Glu  Ile Ala Tyr 
    1550                 1555                 1560             


Ile Ser  Lys Pro Gly Ile Leu  Gly Val Asn His Thr  Pro Ile Leu 
    1565                 1570                 1575             


Pro Ala  His Ser Glu Thr Cys  Lys Val Pro Thr Leu  Leu Lys Lys 
    1580                 1585                 1590             


Pro Ala  Ser Tyr Val Ser Asp  Phe Lys Glu Lys His  Cys Ser Ala 
    1595                 1600                 1605             


Asn His  Thr Ala Leu Ile Ala  Asn Leu Ser Gln Ile  Leu Gln Arg 
    1610                 1615                 1620             


Ala Asp  Glu Ala Ser Ser Leu  Gln Ile Leu Gln Glu  Glu Thr Lys 
    1625                 1630                 1635             


Val Cys  Leu Asn Ile Leu Pro  Leu Phe Val Glu Ala  Phe Glu Arg 
    1640                 1645                 1650             


Lys Gln  Glu Cys Ser Val Glu  Gln Ile Leu Ile Ser  Arg Glu Leu 
    1655                 1660                 1665             


Leu Val  Asp Gln Asn Leu Trp  Asn Asn Cys Lys His  Thr Leu Lys 
    1670                 1675                 1680             


Pro Cys  Ala Val Asp Thr Leu  Val Glu Leu Gln Met  Met Met Glu 
    1685                 1690                 1695             


Thr Ile  Gln Phe Ile Glu Asn  Lys Lys Arg His Leu  Glu Gly Glu 
    1700                 1705                 1710             


Pro Thr  Leu Arg Ser Leu Leu  Trp Tyr Asp Glu Thr  Leu Tyr Ala 
    1715                 1720                 1725             


Glu Leu  Leu Gly Lys Pro Arg  Gly Phe Gln Gln Gln  Ser Asn Phe 
    1730                 1735                 1740             


Tyr Pro  Gly Phe Gln Gly Arg  Leu Lys Tyr Asn Ala  Phe Cys Glu 
    1745                 1750                 1755             


Leu Gln  Thr Tyr His Asp Gln  Leu Val Glu Leu Leu  Glu Glu Thr 
    1760                 1765                 1770             


Lys Arg  Glu Lys Asn Ser Tyr  Tyr Val Phe Leu Lys  Tyr Lys Arg 
    1775                 1780                 1785             


Gln Val  Asn Glu Cys Glu Ala  Ile Met Glu His Cys  Ser Asp Cys 
    1790                 1795                 1800             


Phe Asp  Phe Ser Leu Ser Val  Pro Phe Thr Cys Gly  Val Asn Phe 
    1805                 1810                 1815             


Gly Asp  Ser Leu Glu Asp Leu  Glu Ile Leu Arg Lys  Ser Thr Leu 
    1820                 1825                 1830             


Lys Leu  Ile Asn Val Cys Gly  Asp Ser Pro Lys Val  His Ser Tyr 
    1835                 1840                 1845             


Pro Gly  Lys Gln Asp His Leu  Trp Ile Ile Ile Glu  Met Ile Ser 
    1850                 1855                 1860             


Ser Lys  Val Asn Phe Ile Lys  Asn Asn Glu Ala Val  Arg Val Lys 
    1865                 1870                 1875             


Ile Ser  Leu Tyr Gly Leu Glu  His Ile Phe Phe Asp  Ala Ala Lys 
    1880                 1885                 1890             


Asn Leu  Val Trp Lys Glu Arg  Thr Gln Ser Phe Ser  Lys Lys Tyr 
    1895                 1900                 1905             


Ser Gln  Lys Lys Asp Glu Glu  Arg Leu Leu Arg Val  Asn Lys Cys 
    1910                 1915                 1920             


Ala Phe  Ser Lys Leu Gln Lys  Ile Tyr Asp Thr Leu  Ser Lys Asp 
    1925                 1930                 1935             


Leu Asn  Asn Glu Pro Ile Ser  Pro Ile Gly Leu Glu  Glu Asp Thr 
    1940                 1945                 1950             


Ile Ile  Ala Ser Arg Lys Ser  Asp His Pro Ile Asn  Glu Ala Thr 
    1955                 1960                 1965             


Ile Ser  Ile Glu Asn Ser Lys  Phe Asn Ser Asn Leu  Leu Ala His 
    1970                 1975                 1980             


Pro Asp  Ile Cys Cys Ile Ser  Glu Ile Leu Asp Gln  Ala Glu Phe 
    1985                 1990                 1995             


Ala Asp  Leu Lys Lys Leu Gln  Asp Leu Thr Leu Arg  Cys Thr Asp 
    2000                 2005                 2010             


His Leu  Glu Ile Leu Lys Lys  Tyr Phe Gln Met Leu  Gln Asp Asn 
    2015                 2020                 2025             


Asn Met  Asp Asn Ile Phe Ile  Thr Glu Glu Asn Val  Leu Asp Val 
    2030                 2035                 2040             


Val Ile  Asn His Ser His Glu  Ala Ile Ile Leu Lys  Pro Glu Ala 
    2045                 2050                 2055             


Ile Glu  Met Tyr Ile Glu Ile  Val Met Val Ser Glu  Thr Ile His 
    2060                 2065                 2070             


Phe Leu  Lys Asn Ser Ile Ala  Lys Lys Leu Asp Lys  Gln Arg Phe 
    2075                 2080                 2085             


Arg Gly  Met Leu Trp Phe Asp  Leu Ser Leu Leu Pro  Glu Leu Val 
    2090                 2095                 2100             


Gln Cys  Gln Glu Lys Met Ala  Ser Phe Ser Phe Leu  Lys Asp Asn 
    2105                 2110                 2115             


Ser Thr  Asp Val Cys Leu Trp  Lys Val Ile Glu Thr  Ala Val Ser 
    2120                 2125                 2130             


Glu Leu  Lys Lys Asp Leu Asp  Ile Ile Cys Lys Tyr  Asn Glu Ala 
    2135                 2140                 2145             


Val Asn  Cys Ser Tyr Ala Ile  His Leu Leu Ser Arg  Glu Leu Gln 
    2150                 2155                 2160             


Glu Leu  Ser Glu Ile Lys Lys  Leu Leu Lys Lys Ser  Lys Tyr Phe 
    2165                 2170                 2175             


Ile Ser  Thr Tyr Ile Asp Phe  Val Pro Tyr Ile Ala  Ser Ile Asn 
    2180                 2185                 2190             


Tyr Gly  Ser Thr Val Thr Glu  Leu Glu Tyr Asn Tyr  Asn Gln Phe 
    2195                 2200                 2205             


Ser Thr  Leu Leu Lys Asn Val  Met Ser Ala Pro Arg  Lys Asp Leu 
    2210                 2215                 2220             


Gly Lys  Met Ala His Ile Arg  Lys Val Met Lys Thr  Ile Glu His 
    2225                 2230                 2235             


Met Lys  Met Ile Cys Thr Lys  Asn Ala Glu Leu Thr  Ile Ser Phe 
    2240                 2245                 2250             


Phe Leu  Cys Gln Met Leu Tyr  Asn Arg Arg Lys Ile  Leu Gln Leu 
    2255                 2260                 2265             


Lys Arg  Lys Glu Lys Met Asn  Ile His Ile Val Lys  Pro Gly Glu 
    2270                 2275                 2280             


Asn Asn  Asn Lys Phe Ser Ile  Ser Thr Met Leu Pro  Pro Val Ser 
    2285                 2290                 2295             


Glu Cys  Ile Asn Lys Asn Ile  Ser Asn Ser Ser Lys  Lys Arg Pro 
    2300                 2305                 2310             


Ser Thr  Val Asp Lys Cys Glu  Asp Ser Gln Glu Gln  Gln Gln Asp 
    2315                 2320                 2325             


Thr Thr  Val Ser Ser Cys Lys  Lys Leu Lys Val Asp  Met Lys Asp 
    2330                 2335                 2340             


Val Thr  Lys Ile Asn Arg Glu  Lys Ala Thr Phe Lys  His Pro Arg 
    2345                 2350                 2355             


Thr Thr  Gly Ser His Pro Lys  Ser Glu Asn Lys Ile  Val Pro Ser 
    2360                 2365                 2370             


Ser Cys  Asp Ser Leu Lys Arg  Asn His Leu Thr Pro  Lys Lys Val 
    2375                 2380                 2385             


Glu Met  Gln Arg Ser Leu Pro  Gly Ser Leu Leu Pro  Leu Glu Asn 
    2390                 2395                 2400             


Pro Lys  Asp Thr Cys Ala Ser  Lys Ser Glu Ser Lys  Ile Asp Leu 
    2405                 2410                 2415             


Thr Val  Ser Ser Asp His Phe  Ser Gly Gln Gln Glu  Asn Leu Asn 
    2420                 2425                 2430             


Ser Met  Lys Lys Arg Asn Val  Asn Phe Ser Ala Ala  Glu Thr Lys 
    2435                 2440                 2445             


Ser Asp  Lys Lys Asp Cys Ala  Ala Phe Ala Ile Cys  Asp Gln Lys 
    2450                 2455                 2460             


Ser Val  His Gly Thr Phe Ser  Pro Asp His Gly Thr  Leu Leu Gln 
    2465                 2470                 2475             


Lys Phe  Leu Lys Asn Ser Pro  Asp Pro Thr Gln Lys  Ser Cys Leu 
    2480                 2485                 2490             


Ser Asp  Ile Asn Pro Glu Thr  Asp Val Ser Leu Val  Pro Asp Ala 
    2495                 2500                 2505             


Ser Val  Leu Ser Lys Pro Ile  Phe Cys Phe Val Lys  Asp Val His 
    2510                 2515                 2520             


Pro Asp  Leu Glu Met Asn Asp  Thr Val Phe Glu Leu  Gln Asp Asn 
    2525                 2530                 2535             


Asp Ile  Val Asn Ser Ser Ile  Lys Asn Ser Ser Cys  Met Thr Ser 
    2540                 2545                 2550             


Pro Glu  Pro Ile Cys Ile Gln  Asn Lys Ile Pro Thr  Leu Gln Ile 
    2555                 2560                 2565             


Asn Lys  Leu Gln Pro Thr Glu  Thr Glu Ser Glu Asp  Lys Tyr Met 
    2570                 2575                 2580             


Lys Asp  Thr Leu Asn Pro Asn  Thr Val His Thr Phe  Gly Ala Ser 
    2585                 2590                 2595             


Gly His  Ile Thr Leu Asn Val  Asn Gln Gly Ala Glu  Tyr Ser Leu 
    2600                 2605                 2610             


Ser Glu  Gln Gln Asn Asp Lys  Asn Ser Lys Val Leu  Met Gln Asn 
    2615                 2620                 2625             


Ala Ala  Thr Tyr Trp Asn Glu  Leu Pro Gln Ser Ala  Cys Asn Pro 
    2630                 2635                 2640             


Thr Tyr  Asn Ser Ser Glu His  Leu Phe Gly Thr Ser  Tyr Pro Tyr 
    2645                 2650                 2655             


Ser Ala  Trp Cys Val Tyr Gln  Tyr Ser Asn Ser Asn  Gly Asn Ala 
    2660                 2665                 2670             


Ile Thr  Gln Thr Tyr Gln Gly  Ile Thr Ser Tyr Glu  Val Gln Pro 
    2675                 2680                 2685             


Ser Pro  Ser Gly Leu Leu Thr  Thr Val Ala Ser Thr  Ala Gln Gly 
    2690                 2695                 2700             


Thr His  Ser Asn Leu Leu Tyr  Ser Gln Tyr Phe Thr  Tyr Phe Ala 
    2705                 2710                 2715             


Gly Glu  Pro Gln Ala Asn Gly  Phe Val Pro Val Asn  Gly Tyr Phe 
    2720                 2725                 2730             


Gln Ser  Gln Ile Pro Ala Ser  Asn Phe Arg Gln Pro  Ile Phe Ser 
    2735                 2740                 2745             


Gln Tyr  Ala Ser His Gln Pro  Leu Pro Gln Ala Thr  Tyr Pro Tyr 
    2750                 2755                 2760             


Leu Pro  Asn Arg Phe Val Pro  Pro Glu Val Pro Trp  Val Tyr Ala 
    2765                 2770                 2775             


Pro Trp  His Gln Glu Ser Phe  His Pro Gly His 
    2780                 2785                 


<210>  120
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asn Pro Ser Ala Pro Ser Tyr Pro Met Ala Ser Leu Tyr Val Gly 
1               5                   10                  15      


Asp Leu His Pro Asp Val Thr Glu Ala Met Leu Tyr Glu Lys Phe Ser 
            20                  25                  30          


Pro Ala Gly Pro Ile Leu Ser Ile Arg Val Cys Arg Asp Met Ile Thr 
        35                  40                  45              


Arg Arg Ser Leu Gly Tyr Ala Tyr Val Asn Phe Gln Gln Pro Ala Asp 
    50                  55                  60                  


Ala Glu Arg Ala Leu Asp Thr Met Asn Phe Asp Val Ile Lys Gly Lys 
65                  70                  75                  80  


Pro Val Arg Ile Met Trp Ser Gln Arg Asp Pro Ser Leu Arg Lys Ser 
                85                  90                  95      


Gly Val Gly Asn Ile Phe Ile Lys Asn Leu Asp Lys Ser Ile Asp Asn 
            100                 105                 110         


Lys Ala Leu Tyr Asp Thr Phe Ser Ala Phe Gly Asn Ile Leu Ser Cys 
        115                 120                 125             


Lys Val Val Cys Asp Glu Asn Gly Ser Lys Gly Tyr Gly Phe Val His 
    130                 135                 140                 


Phe Glu Thr Gln Glu Ala Ala Glu Arg Ala Ile Glu Lys Met Asn Gly 
145                 150                 155                 160 


Met Leu Leu Asn Asp Arg Lys Val Phe Val Gly Arg Phe Lys Ser Arg 
                165                 170                 175     


Lys Glu Arg Glu Ala Glu Leu Gly Ala Arg Ala Lys Glu Phe Thr Asn 
            180                 185                 190         


Val Tyr Ile Lys Asn Phe Gly Glu Asp Met Asp Asp Glu Arg Leu Lys 
        195                 200                 205             


Asp Leu Phe Gly Lys Phe Gly Pro Ala Leu Ser Val Lys Val Met Thr 
    210                 215                 220                 


Asp Glu Ser Gly Lys Ser Lys Gly Phe Gly Phe Val Ser Phe Glu Arg 
225                 230                 235                 240 


His Glu Asp Ala Gln Lys Ala Val Asp Glu Met Asn Gly Lys Glu Leu 
                245                 250                 255     


Asn Gly Lys Gln Ile Tyr Val Gly Arg Ala Gln Lys Lys Val Glu Arg 
            260                 265                 270         


Gln Thr Glu Leu Lys Arg Lys Phe Glu Gln Met Lys Gln Asp Arg Ile 
        275                 280                 285             


Thr Arg Tyr Gln Gly Val Asn Leu Tyr Val Lys Asn Leu Asp Asp Gly 
    290                 295                 300                 


Ile Asp Asp Glu Arg Leu Arg Lys Glu Phe Ser Pro Phe Gly Thr Ile 
305                 310                 315                 320 


Thr Ser Ala Lys Val Met Met Glu Gly Gly Arg Ser Lys Gly Phe Gly 
                325                 330                 335     


Phe Val Cys Phe Ser Ser Pro Glu Glu Ala Thr Lys Ala Val Thr Glu 
            340                 345                 350         


Met Asn Gly Arg Ile Val Ala Thr Lys Pro Leu Tyr Val Ala Leu Ala 
        355                 360                 365             


Gln Arg Lys Glu Glu Arg Gln Ala His Leu Thr Asn Gln Tyr Met Gln 
    370                 375                 380                 


Arg Met Ala Ser Val Arg Ala Val Pro Asn Pro Val Ile Asn Pro Tyr 
385                 390                 395                 400 


Gln Pro Ala Pro Pro Ser Gly Tyr Phe Met Ala Ala Ile Pro Gln Thr 
                405                 410                 415     


Gln Asn Arg Ala Ala Tyr Tyr Pro Pro Ser Gln Ile Ala Gln Leu Arg 
            420                 425                 430         


Pro Ser Pro Arg Trp Thr Ala Gln Gly Ala Arg Pro His Pro Phe Gln 
        435                 440                 445             


Asn Met Pro Gly Ala Ile Arg Pro Ala Ala Pro Arg Pro Pro Phe Ser 
    450                 455                 460                 


Thr Met Arg Pro Ala Ser Ser Gln Val Pro Arg Val Met Ser Thr Gln 
465                 470                 475                 480 


Arg Val Ala Asn Thr Ser Thr Gln Thr Met Gly Pro Arg Pro Ala Ala 
                485                 490                 495     


Ala Ala Ala Ala Ala Thr Pro Ala Val Arg Thr Val Pro Gln Tyr Lys 
            500                 505                 510         


Tyr Ala Ala Gly Val Arg Asn Pro Gln Gln His Leu Asn Ala Gln Pro 
        515                 520                 525             


Gln Val Thr Met Gln Gln Pro Ala Val His Val Gln Gly Gln Glu Pro 
    530                 535                 540                 


Leu Thr Ala Ser Met Leu Ala Ser Ala Pro Pro Gln Glu Gln Lys Gln 
545                 550                 555                 560 


Met Leu Gly Glu Arg Leu Phe Pro Leu Ile Gln Ala Met His Pro Thr 
                565                 570                 575     


Leu Ala Gly Lys Ile Thr Gly Met Leu Leu Glu Ile Asp Asn Ser Glu 
            580                 585                 590         


Leu Leu His Met Leu Glu Ser Pro Glu Ser Leu Arg Ser Lys Val Asp 
        595                 600                 605             


Glu Ala Val Ala Val Leu Gln Ala His Gln Ala Lys Glu Ala Ala Gln 
    610                 615                 620                 


Lys Ala Val Asn Ser Ala Thr Gly Val Pro Thr Val 
625                 630                 635     


<210>  121
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala 
            20                  25                  30          


Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu 
        35                  40                  45              


Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly 
    50                  55                  60                  


Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser 
65                  70                  75                  80  


Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val 
                85                  90                  95      


Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val 
            100                 105                 110         


Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser 
        115                 120                 125             


Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu 
    130                 135                 140                 


Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser 
145                 150                 155                 160 


Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp 
                165                 170                 175     


Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val 
            180                 185                 190         


Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp 
        195                 200                 205             


Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser 
    210                 215                 220                 


Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala 
225                 230                 235                 240 


Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His 
                245                 250                 255     


Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu 
            260                 265                 270         


His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr 
        275                 280                 285             


Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr 
    290                 295                 300                 


Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser 
305                 310                 315                 320 


Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn 
                325                 330                 335     


Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser 
            340                 345                 350         


Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val 
        355                 360                 365             


Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala 
    370                 375                 380                 


Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val 
                405                 410                 415     


Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile 
            420                 425                 430         


Leu Asn Thr Phe Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe 
        435                 440                 445             


Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln 
    450                 455                 460                 


Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg 
465                 470                 475                 480 


Val 
    


<210>  122
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Gly Lys Lys Lys 
            180                 185                 190         


Glu His Lys Lys Val Lys Ser Thr Arg Asp Ile Val Pro Phe Ser Glu 
        195                 200                 205             


Leu Gly Thr Thr Pro Ser Gly Gly Gly Phe Phe Gln Gly Ile Ser Phe 
    210                 215                 220                 


Pro Glu Ile Ser Thr Arg Pro Pro Leu Gly Ser Thr Glu Leu Gln Ala 
225                 230                 235                 240 


Ala Lys Lys Val His Thr Ser Lys Gly Asp Leu Pro Arg Glu Pro Leu 
                245                 250                 255     


Val Ala Thr Asn Leu Pro Gly Arg Gly Gln Leu Gln Lys Leu Ala Ser 
            260                 265                 270         


Glu Arg Asn Leu Phe Ile Ser Cys Lys Ser Ser His Asp Arg Cys Leu 
        275                 280                 285             


Glu Lys Ser Ser Ser Ser Ser Ser Gln Pro Glu His Ser Ala Met Leu 
    290                 295                 300                 


Val Ser Thr Ala Ala Ser Pro Ser Leu Ile Lys Glu Thr Thr Thr Gly 
305                 310                 315                 320 


Tyr Tyr Lys Asp Ile Val Glu Asn Ile Cys Gly Arg Glu Lys Ser Gly 
                325                 330                 335     


Ile Gln Pro Leu Cys Pro Glu Arg Ser His Ile Ser Asp Gln Ser Pro 
            340                 345                 350         


Leu Ser Ser Lys Arg Lys Ala Leu Glu Glu Ser Glu Ser Ser Gln Leu 
        355                 360                 365             


Ile Ser Pro Pro Leu Ala Gln Ala Ile Arg Asp Tyr Val Asn Ser Leu 
    370                 375                 380                 


Leu Val Gln Gly Gly Val Gly Ser Leu Pro Gly Thr Ser Asn Ser Met 
385                 390                 395                 400 


Pro Pro Leu Asp Val Glu Asn Ile Gln Lys Arg Ile Asp Gln Ser Lys 
                405                 410                 415     


Phe Gln Glu Thr Glu Phe Leu Ser Pro Pro Arg Lys Val Pro Arg Leu 
            420                 425                 430         


Ser Glu Lys Ser Val Glu Glu Arg Asp Ser Gly Ser Phe Val Ala Phe 
        435                 440                 445             


Gln Asn Ile Pro Gly Ser Glu Leu Met Ser Ser Phe Ala Lys Thr Val 
    450                 455                 460                 


Val Ser His Ser Leu Thr Thr Leu Gly Leu Glu Val Ala Lys Gln Ser 
465                 470                 475                 480 


Gln His Asp Lys Ile Asp Ala Ser Glu Leu Ser Phe Pro Phe His Glu 
                485                 490                 495     


Ser Ile Leu Lys Val Ile Glu Glu Glu Trp Gln Gln Val Asp Arg Gln 
            500                 505                 510         


Leu Pro Ser Leu Ala Cys Lys Tyr Pro Val Ser Ser Arg Glu Ala Thr 
        515                 520                 525             


Gln Ile Leu Ser Val Pro Lys Val Asp Asp Glu Ile Leu Gly Phe Ile 
    530                 535                 540                 


Ser Glu Ala Thr Pro Leu Gly Gly Ile Gln Ala Ala Ser Thr Glu Ser 
545                 550                 555                 560 


Cys Asn Gln Gln Leu Asp Leu Ala Leu Cys Arg Ala Tyr Glu Ala Ala 
                565                 570                 575     


Ala Ser Ala Leu Gln Ile Ala Thr His Thr Ala Phe Val Ala Lys Ala 
            580                 585                 590         


Met Gln Ala Asp Ile Ser Gln Ala Ala Gln Ile Leu Ser Ser Asp Pro 
        595                 600                 605             


Ser Arg Thr His Gln Ala Leu Gly Ile Leu Ser Lys Thr Tyr Asp Ala 
    610                 615                 620                 


Ala Ser Tyr Ile Cys Glu Ala Ala Phe Asp Glu Val Lys Met Ala Ala 
625                 630                 635                 640 


His Thr Met Gly Asn Ala Thr Val Gly Arg Arg Tyr Leu Trp Leu Lys 
                645                 650                 655     


Asp Cys Lys Ile Asn Leu Ala Ser Lys Asn Lys Leu Ala Ser Thr Pro 
            660                 665                 670         


Phe Lys Gly Gly Thr Leu Phe Gly Gly Glu Val Cys Lys Val Ile Lys 
        675                 680                 685             


Lys Arg Gly Asn Lys His 
    690                 


<210>  123
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Val  Arg Asn His Tyr Asn  Glu Glu Met 
    1190                 1195                 1200             


Ser Asn  Leu Arg Asn Lys Tyr  Glu Thr Glu Ile Asn  Ile Thr Lys 
    1205                 1210                 1215             


Thr Thr  Ile Lys Glu Ile Ser  Met Gln Lys Glu Asp  Asp Ser Lys 
    1220                 1225                 1230             


Asn Leu  Arg Asn Gln Leu Asp  Arg Leu Ser Arg Glu  Asn Arg Asp 
    1235                 1240                 1245             


Leu Lys  Asp Glu Ile Val Arg  Leu Asn Asp Ser Ile  Leu Gln Ala 
    1250                 1255                 1260             


Thr Glu  Gln Arg Arg Arg Ala  Glu Glu Asn Ala Leu  Gln Gln Lys 
    1265                 1270                 1275             


Ala Cys  Gly Ser Glu Ile Met  Gln Lys Lys Gln His  Leu Glu Ile 
    1280                 1285                 1290             


Glu Leu  Lys Gln Val Met Gln  Gln Arg Ser Glu Asp  Asn Ala Arg 
    1295                 1300                 1305             


His Lys  Gln Ser Leu Glu Glu  Ala Ala Lys Thr Ile  Gln Asp Lys 
    1310                 1315                 1320             


Asn Lys  Glu Ile Glu Arg Leu  Lys Ala Glu Phe Gln  Glu Glu Ala 
    1325                 1330                 1335             


Lys Arg  Arg Trp Glu Tyr Glu  Asn Glu Leu Ser Lys  Val Arg Asn 
    1340                 1345                 1350             


Asn Tyr  Asp Glu Glu Ile Ile  Ser Leu Lys Asn Gln  Phe Glu Thr 
    1355                 1360                 1365             


Glu Ile  Asn Ile Thr Lys Thr  Thr Ile His Gln Leu  Thr Met Gln 
    1370                 1375                 1380             


Lys Glu  Glu Asp Thr Ser Gly  Tyr Arg Ala Gln Ile  Asp Asn Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asn Arg Ser Leu  Ser Glu Glu Ile Lys  Arg Leu Lys 
    1400                 1405                 1410             


Asn Thr  Leu Thr Gln Thr Thr  Glu Asn Leu Arg Arg  Val Glu Glu 
    1415                 1420                 1425             


Asp Ile  Gln Gln Gln Lys Ala  Thr Gly Ser Glu Val  Ser Gln Arg 
    1430                 1435                 1440             


Lys Gln  Gln Leu Glu Val Glu  Leu Arg Gln Val Thr  Gln Met Arg 
    1445                 1450                 1455             


Thr Glu  Glu Ser Val Arg Tyr  Lys Gln Ser Leu Asp  Asp Ala Ala 
    1460                 1465                 1470             


Lys Thr  Ile Gln Asp Lys Asn  Lys Glu Ile Glu Arg  Leu Lys Gln 
    1475                 1480                 1485             


Leu Ile  Asp Lys Glu Thr Asn  Asp Arg Lys Cys Leu  Glu Asp Glu 
    1490                 1495                 1500             


Asn Ala  Arg Leu Gln Arg Val  Gln Tyr Asp Leu Gln  Lys Ala Asn 
    1505                 1510                 1515             


Ser Ser  Ala Thr Glu Thr Ile  Asn Lys Leu Lys Val  Gln Glu Gln 
    1520                 1525                 1530             


Glu Leu  Thr Arg Leu Arg Ile  Asp Tyr Glu Arg Val  Ser Gln Glu 
    1535                 1540                 1545             


Arg Thr  Val Lys Asp Gln Asp  Ile Thr Arg Phe Gln  Asn Ser Leu 
    1550                 1555                 1560             


Lys Glu  Leu Gln Leu Gln Lys  Gln Lys Val Glu Glu  Glu Leu Asn 
    1565                 1570                 1575             


Arg Leu  Lys Arg Thr Ala Ser  Glu Asp Ser Cys Lys  Arg Lys Lys 
    1580                 1585                 1590             


Leu Glu  Glu Glu Leu Glu Gly  Met Arg Arg Ser Leu  Lys Glu Gln 
    1595                 1600                 1605             


Ala Ile  Lys Ile Thr Asn Leu  Thr Gln Gln Leu Glu  Gln Ala Ser 
    1610                 1615                 1620             


Ile Val  Lys Lys Arg Ser Glu  Asp Asp Leu Arg Gln  Gln Arg Asp 
    1625                 1630                 1635             


Val Leu  Asp Gly His Leu Arg  Glu Lys Gln Arg Thr  Gln Glu Glu 
    1640                 1645                 1650             


Leu Arg  Arg Leu Ser Ser Glu  Val Glu Ala Leu Arg  Arg Gln Leu 
    1655                 1660                 1665             


Leu Gln  Glu Gln Glu Ser Val  Lys Gln Ala His Leu  Arg Asn Glu 
    1670                 1675                 1680             


His Phe  Gln Lys Ala Ile Glu  Asp Lys Ser Arg Ser  Leu Asn Glu 
    1685                 1690                 1695             


Ser Lys  Ile Glu Ile Glu Arg  Leu Gln Ser Leu Thr  Glu Asn Leu 
    1700                 1705                 1710             


Thr Lys  Glu His Leu Met Leu  Glu Glu Glu Leu Arg  Asn Leu Arg 
    1715                 1720                 1725             


Leu Glu  Tyr Asp Asp Leu Arg  Arg Gly Arg Ser Glu  Ala Asp Ser 
    1730                 1735                 1740             


Asp Lys  Asn Ala Thr Ile Leu  Glu Leu Arg Ser Gln  Leu Gln Ile 
    1745                 1750                 1755             


Ser Asn  Asn Arg Thr Leu Glu  Leu Gln Gly Leu Ile  Asn Asp Leu 
    1760                 1765                 1770             


Gln Arg  Glu Arg Glu Asn Leu  Arg Gln Glu Ile Glu  Lys Phe Gln 
    1775                 1780                 1785             


Lys Gln  Ala Leu Glu Ala Ser  Asn Arg Ile Gln Glu  Ser Lys Asn 
    1790                 1795                 1800             


Gln Cys  Thr Gln Val Val Gln  Glu Arg Glu Ser Leu  Leu Val Lys 
    1805                 1810                 1815             


Ile Lys  Val Leu Glu Gln Asp  Lys Ala Arg Leu Gln  Arg Leu Glu 
    1820                 1825                 1830             


Asp Glu  Leu Asn Arg Ala Lys  Ser Thr Leu Glu Ala  Glu Thr Arg 
    1835                 1840                 1845             


Val Lys  Gln Arg Leu Glu Cys  Glu Lys Gln Gln Ile  Gln Asn Asp 
    1850                 1855                 1860             


Leu Asn  Gln Trp Lys Thr Gln  Tyr Ser Arg Lys Glu  Glu Ala Ile 
    1865                 1870                 1875             


Arg Lys  Ile Glu Ser Glu Arg  Glu Lys Ser Glu Arg  Glu Lys Asn 
    1880                 1885                 1890             


Ser Leu  Arg Ser Glu Ile Glu  Arg Leu Gln Ala Glu  Ile Lys Arg 
    1895                 1900                 1905             


Ile Glu  Glu Arg Cys Arg Arg  Lys Leu Glu Asp Ser  Thr Arg Glu 
    1910                 1915                 1920             


Thr Gln  Ser Gln Leu Glu Thr  Glu Arg Ser Arg Tyr  Gln Arg Glu 
    1925                 1930                 1935             


Ile Asp  Lys Leu Arg Gln Arg  Pro Tyr Gly Ser His  Arg Glu Thr 
    1940                 1945                 1950             


Gln Thr  Glu Cys Glu Trp Thr  Val Asp Thr Ser Lys  Leu Val Phe 
    1955                 1960                 1965             


Asp Gly  Leu Arg Lys Lys Val  Thr Ala Met Gln Leu  Tyr Glu Cys 
    1970                 1975                 1980             


Gln Leu  Ile Asp Lys Thr Thr  Leu Asp Lys Leu Leu  Lys Gly Lys 
    1985                 1990                 1995             


Lys Ser  Val Glu Glu Val Ala  Ser Glu Ile Gln Pro  Phe Leu Arg 
    2000                 2005                 2010             


Gly Ala  Gly Ser Ile Ala Gly  Ala Ser Ala Ser Pro  Lys Glu Lys 
    2015                 2020                 2025             


Tyr Ser  Leu Val Glu Ala Lys  Arg Lys Lys Leu Ile  Ser Pro Glu 
    2030                 2035                 2040             


Ser Thr  Val Met Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Gly Ile 
    2045                 2050                 2055             


Ile Asp  Pro His Arg Asn Glu  Lys Leu Thr Val Asp  Ser Ala Ile 
    2060                 2065                 2070             


Ala Arg  Asp Leu Ile Asp Phe  Asp Asp Arg Gln Gln  Ile Tyr Ala 
    2075                 2080                 2085             


Ala Glu  Lys Ala Ile Thr Gly  Phe Asp Asp Pro Phe  Ser Gly Lys 
    2090                 2095                 2100             


Thr Val  Ser Val Ser Glu Ala  Ile Lys Lys Asn Leu  Ile Asp Arg 
    2105                 2110                 2115             


Glu Thr  Gly Met Arg Leu Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2120                 2125                 2130             


Val Val  Asp Pro Val Asn Ser  Val Phe Leu Pro Lys  Asp Val Ala 
    2135                 2140                 2145             


Leu Ala  Arg Gly Leu Ile Asp  Arg Asp Leu Tyr Arg  Ser Leu Asn 
    2150                 2155                 2160             


Asp Pro  Arg Asp Ser Gln Lys  Asn Phe Val Asp Pro  Val Thr Lys 
    2165                 2170                 2175             


Lys Lys  Val Ser Tyr Val Gln  Leu Lys Glu Arg Cys  Arg Ile Glu 
    2180                 2185                 2190             


Pro His  Thr Gly Leu Leu Leu  Leu Ser Val Gln Lys  Arg Ser Met 
    2195                 2200                 2205             


Ser Phe  Gln Gly Ile Arg Gln  Pro Val Thr Val Thr  Glu Leu Val 
    2210                 2215                 2220             


Asp Ser  Gly Ile Leu Arg Pro  Ser Thr Val Asn Glu  Leu Glu Ser 
    2225                 2230                 2235             


Gly Gln  Ile Ser Tyr Asp Glu  Val Gly Glu Arg Ile  Lys Asp Phe 
    2240                 2245                 2250             


Leu Gln  Gly Ser Ser Cys Ile  Ala Gly Ile Tyr Asn  Glu Thr Thr 
    2255                 2260                 2265             


Lys Gln  Lys Leu Gly Ile Tyr  Glu Ala Met Lys Ile  Gly Leu Val 
    2270                 2275                 2280             


Arg Pro  Gly Thr Ala Leu Glu  Leu Leu Glu Ala Gln  Ala Ala Thr 
    2285                 2290                 2295             


Gly Phe  Ile Val Asp Pro Val  Ser Asn Leu Arg Leu  Pro Val Glu 
    2300                 2305                 2310             


Glu Ala  Tyr Lys Arg Gly Leu  Val Gly Ile Glu Phe  Lys Glu Lys 
    2315                 2320                 2325             


Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly Tyr Asn  Asp Pro Glu 
    2330                 2335                 2340             


Thr Gly  Asn Ile Ile Ser Leu  Phe Gln Ala Met Asn  Lys Glu Leu 
    2345                 2350                 2355             


Ile Glu  Lys Gly His Gly Ile  Arg Leu Leu Glu Ala  Gln Ile Ala 
    2360                 2365                 2370             


Thr Gly  Gly Ile Ile Asp Pro  Lys Glu Ser His Arg  Leu Pro Val 
    2375                 2380                 2385             


Asp Ile  Ala Tyr Lys Arg Gly  Tyr Phe Asn Glu Glu  Leu Ser Glu 
    2390                 2395                 2400             


Ile Leu  Ser Asp Pro Ser Asp  Asp Thr Lys Gly Phe  Phe Asp Pro 
    2405                 2410                 2415             


Asn Thr  Glu Glu Asn Leu Thr  Tyr Leu Gln Leu Lys  Glu Arg Cys 
    2420                 2425                 2430             


Ile Lys  Asp Glu Glu Thr Gly  Leu Cys Leu Leu Pro  Leu Lys Glu 
    2435                 2440                 2445             


Lys Lys  Lys Gln Val Gln Thr  Ser Gln Lys Asn Thr  Leu Arg Lys 
    2450                 2455                 2460             


Arg Arg  Val Val Ile Val Asp  Pro Glu Thr Asn Lys  Glu Met Ser 
    2465                 2470                 2475             


Val Gln  Glu Ala Tyr Lys Lys  Gly Leu Ile Asp Tyr  Glu Thr Phe 
    2480                 2485                 2490             


Lys Glu  Leu Cys Glu Gln Glu  Cys Glu Trp Glu Glu  Ile Thr Ile 
    2495                 2500                 2505             


Thr Gly  Ser Asp Gly Ser Thr  Arg Val Val Leu Val  Asp Arg Lys 
    2510                 2515                 2520             


Thr Gly  Ser Gln Tyr Asp Ile  Gln Asp Ala Ile Asp  Lys Gly Leu 
    2525                 2530                 2535             


Val Asp  Arg Lys Phe Phe Asp  Gln Tyr Arg Ser Gly  Ser Leu Ser 
    2540                 2545                 2550             


Leu Thr  Gln Phe Ala Asp Met  Ile Ser Leu Lys Asn  Gly Val Gly 
    2555                 2560                 2565             


Thr Ser  Ser Ser Met Gly Ser  Gly Val Ser Asp Asp  Val Phe Ser 
    2570                 2575                 2580             


Ser Ser  Arg His Glu Ser Val  Ser Lys Ile Ser Thr  Ile Ser Ser 
    2585                 2590                 2595             


Val Arg  Asn Leu Thr Ile Arg  Ser Ser Ser Phe Ser  Asp Thr Leu 
    2600                 2605                 2610             


Glu Glu  Ser Ser Pro Ile Ala  Ala Ile Phe Asp Thr  Glu Asn Leu 
    2615                 2620                 2625             


Glu Lys  Ile Ser Ile Thr Glu  Gly Ile Glu Arg Gly  Ile Val Asp 
    2630                 2635                 2640             


Ser Ile  Thr Gly Gln Arg Leu  Leu Glu Ala Gln Ala  Cys Thr Gly 
    2645                 2650                 2655             


Gly Ile  Ile His Pro Thr Thr  Gly Gln Lys Leu Ser  Leu Gln Asp 
    2660                 2665                 2670             


Ala Val  Ser Gln Gly Val Ile  Asp Gln Asp Met Ala  Thr Arg Leu 
    2675                 2680                 2685             


Lys Pro  Ala Gln Lys Ala Phe  Ile Gly Phe Glu Gly  Val Lys Gly 
    2690                 2695                 2700             


Lys Lys  Lys Met Ser Ala Ala  Glu Ala Val Lys Glu  Lys Trp Leu 
    2705                 2710                 2715             


Pro Tyr  Glu Ala Gly Gln Arg  Phe Leu Glu Phe Gln  Tyr Leu Thr 
    2720                 2725                 2730             


Gly Gly  Leu Val Asp Pro Glu  Val His Gly Arg Ile  Ser Thr Glu 
    2735                 2740                 2745             


Glu Ala  Ile Arg Lys Gly Phe  Ile Asp Gly Arg Ala  Ala Gln Arg 
    2750                 2755                 2760             


Leu Gln  Asp Thr Ser Ser Tyr  Ala Lys Ile Leu Thr  Cys Pro Lys 
    2765                 2770                 2775             


Thr Lys  Leu Lys Ile Ser Tyr  Lys Asp Ala Ile Asn  Arg Ser Met 
    2780                 2785                 2790             


Val Glu  Asp Ile Thr Gly Leu  Arg Leu Leu Glu Ala  Ala Ser Val 
    2795                 2800                 2805             


Ser Ser  Lys Gly Leu Pro Ser  Pro Tyr Asn Met Ser  Ser Ala Pro 
    2810                 2815                 2820             


Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser Arg Ser  Gly Ser Arg 
    2825                 2830                 2835             


Ser Gly  Ser Arg Ser Gly Ser  Arg Arg Gly Ser Phe  Asp Ala Thr 
    2840                 2845                 2850             


Gly Asn  Ser Ser Tyr Ser Tyr  Ser Tyr Ser Phe Ser  Ser Ser Ser 
    2855                 2860                 2865             


Ile Gly  His 
    2870     


<210>  124
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  125
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ser Asp Tyr Ser Thr Gly Gly Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Pro Pro Pro 
            20                  25                  30          


Gly Pro Pro Gly Ala Gly Asp Arg Gly Gly Gly Gly Pro Gly Gly Gly 
        35                  40                  45              


Gly Pro Gly Gly Gly Ser Ala Gly Gly Pro Ser Gln Pro Pro Gly Gly 
    50                  55                  60                  


Gly Gly Pro Gly Ile Arg Lys Asp Ala Phe Ala Asp Ala Val Gln Arg 
65                  70                  75                  80  


Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp Ala Ala Thr Thr Val 
                85                  90                  95      


Asn Asn Ser Thr Pro Asp Phe Gly Phe Gly Gly Gln Lys Arg Gln Leu 
            100                 105                 110         


Glu Asp Gly Asp Gln Pro Glu Ser Lys Lys Leu Ala Ser Gln Gly Asp 
        115                 120                 125             


Ser Ile Ser Ser Gln Leu Gly Pro Ile His Pro Pro Pro Arg Thr Ser 
    130                 135                 140                 


Met Thr Glu Glu Tyr Arg Val Pro Asp Gly Met Val Gly Leu Ile Ile 
145                 150                 155                 160 


Gly Arg Gly Gly Glu Gln Ile Asn Lys Ile Gln Gln Asp Ser Gly Cys 
                165                 170                 175     


Lys Val Gln Ile Ser Pro Asp Ser Gly Gly Leu Pro Glu Arg Ser Val 
            180                 185                 190         


Ser Leu Thr Gly Ala Pro Glu Ser Val Gln Lys Ala Lys Met Met Leu 
        195                 200                 205             


Asp Asp Ile Val Ser Arg Gly Arg Gly Gly Pro Pro Gly Gln Phe His 
    210                 215                 220                 


Asp Asn Ala Asn Gly Gly Gln Asn Gly Thr Val Gln Glu Ile Met Ile 
225                 230                 235                 240 


Pro Ala Gly Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile 
                245                 250                 255     


Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met Ile Leu Ile Gln Asp 
            260                 265                 270         


Gly Ser Gln Asn Thr Asn Val Asp Lys Pro Leu Arg Ile Ile Gly Asp 
        275                 280                 285             


Pro Tyr Lys Val Gln Gln Ala Cys Glu Met Val Met Asp Ile Leu Arg 
    290                 295                 300                 


Glu Arg Asp Gln Gly Gly Phe Gly Asp Arg Asn Glu Tyr Gly Ser Arg 
305                 310                 315                 320 


Ile Gly Gly Gly Ile Asp Val Pro Val Pro Arg His Ser Val Gly Val 
                325                 330                 335     


Val Ile Gly Arg Ser Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala 
            340                 345                 350         


Gly Val Arg Ile Gln Phe Lys Gln Asp Asp Gly Thr Gly Pro Glu Lys 
        355                 360                 365             


Ile Ala His Ile Met Gly Pro Pro Asp Arg Cys Glu His Ala Ala Arg 
    370                 375                 380                 


Ile Ile Asn Asp Leu Leu Gln Ser Leu Arg Ser Gly Pro Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Gly Pro Gly Met Pro Pro Gly Gly Arg Gly Arg Gly Arg Gly 
                405                 410                 415     


Gln Gly Asn Trp Gly Pro Pro Gly Gly Glu Met Thr Phe Ser Ile Pro 
            420                 425                 430         


Thr His Lys Cys Gly Leu Val Ile Gly Arg Gly Gly Glu Asn Val Lys 
        435                 440                 445             


Ala Ile Asn Gln Gln Thr Gly Ala Phe Val Glu Ile Ser Arg Gln Leu 
    450                 455                 460                 


Pro Pro Asn Gly Asp Pro Asn Phe Lys Leu Phe Ile Ile Arg Gly Ser 
465                 470                 475                 480 


Pro Gln Gln Ile Asp His Ala Lys Gln Leu Ile Glu Glu Lys Ile Glu 
                485                 490                 495     


Gly Pro Leu Cys Pro Val Gly Pro Gly Pro Gly Gly Pro Gly Pro Ala 
            500                 505                 510         


Gly Pro Met Gly Pro Phe Asn Pro Gly Pro Phe Asn Gln Gly Pro Pro 
        515                 520                 525             


Gly Ala Pro Pro His Ala Gly Gly Pro Pro Pro His Gln Tyr Pro Pro 
    530                 535                 540                 


Gln Gly Trp Gly Asn Thr Tyr Pro Gln Trp Gln Pro Pro Ala Pro His 
545                 550                 555                 560 


Asp Pro Ser Lys Ala Ala Ala Ala Ala Ala Asp Pro Asn Ala Ala Trp 
                565                 570                 575     


Ala Ala Tyr Tyr Ser His Tyr Tyr Gln Gln Pro Pro Gly Pro Val Pro 
            580                 585                 590         


Gly Pro Ala Pro Ala Pro Ala Ala Pro Pro Ala Gln Gly Glu Pro Pro 
        595                 600                 605             


Gln Pro Pro Pro Thr Gly Gln Ser Asp Tyr Thr Lys Ala Trp Glu Glu 
    610                 615                 620                 


Tyr Tyr Lys Lys Ile Gly Gln Gln Pro Gln Gln Pro Gly Ala Pro Pro 
625                 630                 635                 640 


Gln Gln Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys Gln Ala 
                645                 650                 655     


Gln Val Ala Thr Gly Gly Gly Pro Gly Ala Pro Pro Gly Ser Gln Pro 
            660                 665                 670         


Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala Tyr 
        675                 680                 685             


Tyr Gly Gln Thr Pro Gly Pro Gly Gly Pro Gln Pro Pro Pro Thr Gln 
    690                 695                 700                 


Gln Gly Gln Gln Gln Ala Gln 
705                 710     


<210>  126
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro 
1               5                   10                  15      


His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
            20                  25                  30          


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
        35                  40                  45              


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
    50                  55                  60                  


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
65                  70                  75                  80  


Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
                85                  90                  95      


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
            100                 105                 110         


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
        115                 120                 125             


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
145                 150                 155                 160 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
                165                 170                 175     


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
            180                 185                 190         


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
        195                 200                 205             


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
    210                 215                 220                 


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
225                 230                 235                 240 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
                245                 250                 255     


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
            260                 265                 270         


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
        275                 280                 285             


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
    290                 295                 300                 


Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala His Thr 
305                 310                 315                 320 


Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu Asp Ser 
                325                 330                 335     


Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys Glu Gln 
            340                 345                 350         


Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His Met Glu 
        355                 360                 365             


Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro Thr Pro 
    370                 375                 380                 


Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn Met Thr 
385                 390                 395                 400 


Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu 
                405                 410                 415     


Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile 
            420                 425                 430         


Ala Thr Ser Pro Thr Ile Leu Val Ser Ala Thr Ser Leu Ile Thr Pro 
        435                 440                 445             


Lys Ser Thr Phe Leu Thr Thr Thr Lys Pro Val Ser Leu Leu Glu Ser 
    450                 455                 460                 


Thr Lys Lys Thr Ile Pro Glu Leu Asp Gln Pro Pro Lys Leu Arg Gly 
465                 470                 475                 480 


Val Leu Gln Gly His Leu Glu Ser Ser Arg Asn Asp Pro Phe Leu His 
                485                 490                 495     


Pro Asp Phe Cys Cys Leu Leu Pro Leu Gly Phe Tyr Val Leu Gly Leu 
            500                 505                 510         


Phe Trp Leu Leu Phe Ala Ser Val Val Leu Ile Leu Leu Leu Ser Trp 
        515                 520                 525             


Val Gly His Val Lys Pro Gln Ala Leu Asp Ser Gly Gln Gly Ala Ala 
    530                 535                 540                 


Leu Thr Thr Ala Thr Gln Thr Thr His Leu Glu Leu Gln Arg Gly Arg 
545                 550                 555                 560 


Gln Val Thr Val Pro Arg Ala Trp Leu Leu Phe Leu Arg Gly Ser Leu 
                565                 570                 575     


Pro Thr Phe Arg Ser Ser Leu Phe Leu Trp Val Arg Pro Asn Gly Arg 
            580                 585                 590         


Val Gly Pro Leu Val Ala Gly Arg Arg Pro Ser Ala Leu Ser Gln Gly 
        595                 600                 605             


Arg Gly Gln Asp Leu Leu Ser Thr Val Ser Ile Arg Tyr Ser Gly His 
    610                 615                 620                 


Ser Leu 
625     


<210>  127
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Met Ala Lys Ser Ala Leu Arg Glu Asn Gly Thr Asn Ser Glu Thr 
1               5                   10                  15      


Phe Arg Gln Arg Phe Arg Arg Phe His Tyr Gln Glu Val Ala Gly Pro 
            20                  25                  30          


Arg Glu Ala Phe Ser Gln Leu Trp Glu Leu Cys Cys Arg Trp Leu Arg 
        35                  40                  45              


Pro Glu Val Arg Thr Lys Glu Gln Ile Val Glu Leu Leu Val Leu Glu 
    50                  55                  60                  


Gln Phe Leu Thr Val Leu Pro Gly Glu Ile Gln Asn Trp Val Gln Glu 
65                  70                  75                  80  


Gln Cys Pro Glu Asn Gly Glu Glu Ala Val Thr Leu Val Glu Asp Leu 
                85                  90                  95      


Glu Arg Glu Pro Gly Arg Pro Arg Ser Ser Val Thr Val Ser Val Lys 
            100                 105                 110         


Gly Gln Glu Val Arg Leu Glu Lys Met Thr Pro Pro Lys Ser Ser Gln 
        115                 120                 125             


Glu Leu Leu Ser Val Arg Gln Glu Ser Val Glu Pro Gln Pro Arg Gly 
    130                 135                 140                 


Val Pro Lys Lys Glu Arg Ala Arg Ser Pro Asp Leu Gly Pro Gln Glu 
145                 150                 155                 160 


Gln Met Asn Pro Lys Glu Lys Leu Lys Pro Phe Gln Arg Ser Gly Leu 
                165                 170                 175     


Pro Phe Pro Lys Ser Gly Val Val Ser Arg Leu Glu Gln Gly Glu Pro 
            180                 185                 190         


Trp Ile Pro Asp Leu Leu Gly Ser Lys Glu Lys Glu Leu Pro Ser Gly 
        195                 200                 205             


Ser His Ile Gly Asp Arg Arg Val His Ala Asp Leu Leu Pro Ser Lys 
    210                 215                 220                 


Lys Asp Arg Arg Ser Trp Val Glu Gln Asp His Trp Ser Phe Glu Asp 
225                 230                 235                 240 


Glu Lys Val Ala Gly Val His Trp Gly Tyr Glu Glu Thr Arg Thr Leu 
                245                 250                 255     


Leu Ala Ile Leu Ser Gln Thr Glu Phe Tyr Glu Ala Leu Arg Asn Cys 
            260                 265                 270         


His Arg Asn Ser Gln Val Tyr Gly Ala Val Ala Glu Arg Leu Arg Glu 
        275                 280                 285             


Tyr Gly Phe Leu Arg Thr Leu Glu Gln Cys Arg Thr Lys Phe Lys Gly 
    290                 295                 300                 


Leu Gln Lys Ser Tyr Arg Lys Val Lys Ser Gly His Pro Pro Glu Thr 
305                 310                 315                 320 


Cys Pro Phe Phe Glu Glu Met Glu Ala Leu Met Ser Ala Gln Val Ile 
                325                 330                 335     


Ala Leu Pro Ser Asn Gly Leu Glu Ala Ala Ala Ser His Ser Gly Leu 
            340                 345                 350         


Val Gly Ser Asp Ala Glu Thr Glu Glu Pro Gly Gln Arg Gly Trp Gln 
        355                 360                 365             


His Glu Glu Gly Ala Glu Glu Ala Val Ala Gln Glu Ser Asp Ser Asp 
    370                 375                 380                 


Asp Met Asp Leu Glu Ala Thr Pro Gln Asp Pro Asn Ser Ala Ala Pro 
385                 390                 395                 400 


Val Val Phe Arg Ser Pro Gly Gly Val His Trp Gly Tyr Glu Glu Thr 
                405                 410                 415     


Lys Thr Tyr Leu Ala Ile Leu Ser Glu Thr Gln Phe Tyr Glu Ala Leu 
            420                 425                 430         


Arg Asn Cys His Arg Asn Ser Gln Leu Tyr Gly Ala Val Ala Glu Arg 
        435                 440                 445             


Leu Trp Glu Tyr Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg Thr Lys 
    450                 455                 460                 


Phe Lys Ser Leu Gln Thr Ser Tyr Arg Lys Val Lys Asn Gly Gln Ala 
465                 470                 475                 480 


Pro Glu Thr Cys Pro Phe Phe Glu Glu Met Asp Ala Leu Val Ser Val 
                485                 490                 495     


Arg Val Ala Ala Pro Pro Asn Asp Gly Gln Glu Glu Thr Ala Ser Cys 
            500                 505                 510         


Pro Val Gln Gly Thr Ser Glu Ala Glu Ala Gln Lys Gln Ala Glu Glu 
        515                 520                 525             


Ala Asp Glu Ala Thr Glu Glu Asp Ser Asp Asp Asp Glu Glu Asp Thr 
    530                 535                 540                 


Glu Ile Pro Pro Gly Ala Val Ile Thr Arg Ala Pro Val Leu Phe Gln 
545                 550                 555                 560 


Ser Pro Arg Gly Phe Glu Ala Gly Phe Glu Asn Glu Asp Asn Ser Lys 
                565                 570                 575     


Arg Asp Ile Ser Glu Glu Val Gln Leu His Arg Thr Leu Leu Ala Arg 
            580                 585                 590         


Ser Glu Arg Lys Ile Pro Arg Tyr Leu His Gln Gly Lys Gly Asn Glu 
        595                 600                 605             


Ser Asp Cys Arg Ser Gly Arg Gln Trp Ala Lys Thr Ser Gly Glu Lys 
    610                 615                 620                 


Arg Gly Lys Leu Thr Leu Pro Glu Lys Ser Leu Ser Glu Val Leu Ser 
625                 630                 635                 640 


Gln Gln Arg Pro Cys Leu Gly Glu Arg Pro Tyr Lys Tyr Leu Lys Tyr 
                645                 650                 655     


Ser Lys Ser Phe Gly Pro Asn Ser Leu Leu Met His Gln Val Ser His 
            660                 665                 670         


Gln Val Glu Asn Pro Tyr Lys Cys Ala Asp Cys Gly Lys Ser Phe Ser 
        675                 680                 685             


Arg Ser Ala Arg Leu Ile Arg His Arg Arg Ile His Thr Gly Glu Lys 
    690                 695                 700                 


Pro Tyr Lys Cys Leu Asp Cys Gly Lys Ser Phe Arg Asp Ser Ser Asn 
705                 710                 715                 720 


Phe Ile Thr His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
                725                 730                 735     


Gly Glu Cys Gly Lys Cys Phe Asn Gln Ser Ser Ser Leu Ile Ile His 
            740                 745                 750         


Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly 
        755                 760                 765             


Lys Ser Phe Asn Asn Ser Ser His Phe Ser Ala His Arg Arg Ile His 
    770                 775                 780                 


Thr Gly Glu Arg Pro His Val Cys Pro Asp Cys Gly Lys Ser Phe Ser 
785                 790                 795                 800 


Lys Ser Ser Asp Leu Arg Ala His His Arg Thr His Thr Gly Glu Lys 
                805                 810                 815     


Pro Tyr Gly Cys His Asp Cys Gly Lys Cys Phe Ser Lys Ser Ser Ala 
            820                 825                 830         


Leu Asn Lys His Gly Glu Ile His Ala Arg Glu Lys Leu Leu Thr Gln 
        835                 840                 845             


Ser Ala Pro Lys 
    850         


<210>  128
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly 
1               5                   10                  15      


Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile 
            20                  25                  30          


Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu 
        35                  40                  45              


Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe 
    50                  55                  60                  


Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg 
65                  70                  75                  80  


Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile 
                85                  90                  95      


Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly 
            100                 105                 110         


Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly 
        115                 120                 125             


Arg Gly Ser Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp 
    130                 135                 140                 


Gly Gly Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly 
145                 150                 155                 160 


Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met 
                165                 170                 175     


Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His 
            180                 185                 190         


Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu 
        195                 200                 205             


Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His 
    210                 215                 220                 


Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu 
225                 230                 235                 240 


Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn 
                245                 250                 255     


Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly 
            260                 265                 270         


Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp 
        275                 280                 285             


Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met 
    290                 295                 300                 


Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly 
305                 310                 315                 320 


Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly 
                325                 330                 335     


Met Ser Gly Gly Gly Trp Arg Gly Met Tyr 
            340                 345     


<210>  129
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  130
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  131
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn His Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gly Pro Lys Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  132
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  133
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala 
1               5                   10                  15      


Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro 
            20                  25                  30          


Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser 
        35                  40                  45              


Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr 
    50                  55                  60                  


Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly 
65                  70                  75                  80  


Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser 
                85                  90                  95      


Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser 
            100                 105                 110         


Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly 
        115                 120                 125             


Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly 
    130                 135                 140                 


Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln 
145                 150                 155                 160 


Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn 
                165                 170                 175     


Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr 
        195                 200                 205             


Gly Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu 
225                 230                 235                 240 


Pro Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly 
                245                 250                 255     


Ser Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly 
            260                 265                 270         


Ser Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe 
        275                 280                 285             


Val Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr 
    290                 295                 300                 


Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro 
305                 310                 315                 320 


Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu 
                325                 330                 335     


Ala Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp 
            340                 345                 350         


Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe 
        355                 360                 365             


Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly 
    370                 375                 380                 


Gly Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly 
                405                 410                 415     


Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr 
            420                 425                 430         


Cys Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys 
        435                 440                 445             


Ala Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met 
    450                 455                 460                 


Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp 
465                 470                 475                 480 


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly 
                485                 490                 495     


Gly Arg Gly Gly Gly Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp 
            500                 505                 510         


Ser Arg Gly Glu His Arg Gln Asp Arg Arg Glu Arg Pro Tyr 
        515                 520                 525     


<210>  134
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Arg Arg Ser Ala Ala Pro Ser Gln Leu Gln Gly Asn Ser Phe Lys 
1               5                   10                  15      


Lys Pro Lys Phe Ile Pro Pro Gly Arg Ser Asn Pro Gly Leu Asn Glu 
            20                  25                  30          


Glu Ile Thr Lys Leu Asn Pro Asp Ile Lys Leu Phe Glu Gly Val Ala 
        35                  40                  45              


Ile Asn Asn Thr Phe Leu Pro Ser Gln Asn Asp Leu Arg Ile Cys Ser 
    50                  55                  60                  


Leu Asn Leu Pro Ser Glu Glu Ser Thr Arg Glu Ile Asn Asn Arg Asp 
65                  70                  75                  80  


Asn Cys Ser Gly Lys Tyr Cys Phe Glu Ala Pro Thr Leu Ala Thr Leu 
                85                  90                  95      


Asp Pro Pro His Thr Val His Ser Ala Pro Lys Glu Val Ala Val Ser 
            100                 105                 110         


Lys Glu Gln Glu Glu Lys Ser Asp Ser Leu Val Lys Tyr Phe Ser Val 
        115                 120                 125             


Val Trp Cys Lys Pro Ser Lys Lys Lys His Lys Lys Trp Glu Gly Asp 
    130                 135                 140                 


Ala Val Leu Ile Val Lys Gly Lys Ser Phe Ile Leu Lys Asn Leu Glu 
145                 150                 155                 160 


Gly Lys Asp Ile Gly Arg Gly Ile Gly Tyr Lys Phe Lys Glu Leu Glu 
                165                 170                 175     


Lys Ile Glu Glu Gly Gln Thr Leu Met Ile Cys Gly Lys Glu Ile Glu 
            180                 185                 190         


Val Met Gly Val Ile Ser Pro Asp Asp Phe Ser Ser Gly Arg Cys Phe 
        195                 200                 205             


Gln Leu Gly Gly Gly Ser Thr Ala Ile Ser His Ser Ser Gln Val Ala 
    210                 215                 220                 


Arg Lys Cys Phe Ser Asn Pro Phe Lys Ser Val Cys Lys Pro Ser Ser 
225                 230                 235                 240 


Lys Glu Asn Arg Gln Asn Asp Phe Gln Asn Cys Lys Pro Arg His Asp 
                245                 250                 255     


Pro Tyr Thr Pro Asn Ser Leu Val Met Pro Arg Pro Asp Lys Asn His 
            260                 265                 270         


Gln Trp Val Phe Asn Lys Asn Cys Phe Pro Leu Val Asp Val Val Ile 
        275                 280                 285             


Asp Pro Tyr Leu Val Tyr His Leu Arg Pro His Gln Lys Glu Gly Ile 
    290                 295                 300                 


Ile Phe Leu Tyr Glu Cys Val Met Gly Met Arg Met Asn Gly Arg Cys 
305                 310                 315                 320 


Gly Ala Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Leu Gln Cys 
                325                 330                 335     


Ile Ser Leu Ile Trp Thr Leu Gln Cys Gln Gly Pro Tyr Gly Gly Lys 
            340                 345                 350         


Pro Val Ile Lys Lys Thr Leu Ile Val Thr Pro Gly Ser Leu Val Asn 
        355                 360                 365             


Asn Trp Lys Lys Glu Phe Gln Lys Trp Leu Gly Ser Glu Arg Ile Lys 
    370                 375                 380                 


Ile Phe Thr Val Asp Gln Asp His Lys Val Glu Glu Phe Ile Lys Ser 
385                 390                 395                 400 


Ile Phe Tyr Ser Val Leu Ile Ile Ser Tyr Glu Met Leu Leu Arg Ser 
                405                 410                 415     


Leu Asp Gln Ile Lys Asn Ile Lys Phe Asp Leu Leu Ile Cys Asp Glu 
            420                 425                 430         


Gly His Arg Leu Lys Asn Ser Ala Ile Lys Thr Thr Thr Ala Leu Ile 
        435                 440                 445             


Ser Leu Ser Cys Glu Lys Arg Ile Ile Leu Thr Gly Thr Pro Ile Gln 
    450                 455                 460                 


Asn Asp Leu Gln Glu Phe Phe Ala Leu Ile Asp Phe Val Asn Pro Gly 
465                 470                 475                 480 


Ile Leu Gly Ser Leu Ser Ser Tyr Arg Lys Ile Tyr Glu Glu Pro Ile 
                485                 490                 495     


Ile Leu Ser Arg Glu Pro Ser Ala Ser Glu Glu Glu Lys Glu Leu Gly 
            500                 505                 510         


Glu Arg Arg Ala Ala Glu Leu Thr Cys Leu Thr Gly Leu Phe Ile Leu 
        515                 520                 525             


Arg Arg Thr Gln Glu Ile Ile Asn Lys Tyr Leu Pro Pro Lys Ile Glu 
    530                 535                 540                 


Asn Val Val Phe Cys Arg Pro Gly Ala Leu Gln Ile Glu Leu Tyr Arg 
545                 550                 555                 560 


Lys Leu Leu Asn Ser Gln Val Val Arg Phe Cys Leu Gln Gly Leu Leu 
                565                 570                 575     


Glu Asn Ser Pro His Leu Ile Cys Ile Gly Ala Leu Lys Lys Leu Cys 
            580                 585                 590         


Asn His Pro Cys Leu Leu Phe Asn Ser Ile Lys Glu Lys Glu Cys Ser 
        595                 600                 605             


Ser Thr Cys Asp Lys Asn Glu Glu Lys Ser Leu Tyr Lys Gly Leu Leu 
    610                 615                 620                 


Ser Val Phe Pro Ala Asp Tyr Asn Pro Leu Leu Phe Thr Glu Lys Glu 
625                 630                 635                 640 


Ser Gly Lys Leu Gln Val Leu Ser Lys Leu Leu Ala Val Ile His Glu 
                645                 650                 655     


Leu Arg Pro Thr Glu Lys Val Val Leu Val Ser Asn Tyr Thr Gln Thr 
            660                 665                 670         


Leu Asn Ile Leu Gln Glu Val Cys Lys Arg His Gly Tyr Ala Tyr Thr 
        675                 680                 685             


Arg Leu Asp Gly Gln Thr Pro Ile Ser Gln Arg Gln Gln Ile Val Asp 
    690                 695                 700                 


Gly Phe Asn Ser Gln His Ser Ser Phe Phe Ile Phe Leu Leu Ser Ser 
705                 710                 715                 720 


Lys Ala Gly Gly Val Gly Leu Asn Leu Ile Gly Gly Ser His Leu Ile 
                725                 730                 735     


Leu Tyr Asp Ile Asp Trp Asn Pro Ala Thr Asp Ile Gln Ala Met Ser 
            740                 745                 750         


Arg Val Trp Arg Asp Gly Gln Lys Tyr Pro Val His Ile Tyr Arg Leu 
        755                 760                 765             


Leu Thr Thr Gly Thr Ile Glu Glu Lys Ile Tyr Gln Arg Gln Ile Ser 
    770                 775                 780                 


Lys Gln Gly Leu Cys Gly Ala Val Val Asp Leu Thr Lys Thr Ser Glu 
785                 790                 795                 800 


His Ile Gln Phe Ser Val Glu Glu Leu Lys Asn Leu Phe Thr Leu His 
                805                 810                 815     


Glu Ser Ser Asp Cys Val Thr His Asp Leu Leu Asp Cys Glu Cys Thr 
            820                 825                 830         


Gly Glu Glu Val His Thr Gly Asp Ser Leu Glu Lys Phe Ile Val Ser 
        835                 840                 845             


Arg Asp Cys Gln Leu Gly Pro His His Gln Lys Ser Asn Ser Leu Lys 
    850                 855                 860                 


Pro Leu Ser Met Ser Gln Leu Lys Gln Trp Lys His Phe Ser Gly Asp 
865                 870                 875                 880 


His Leu Asn Leu Thr Asp Pro Phe Leu Glu Arg Ile Thr Glu Asn Val 
                885                 890                 895     


Ser Phe Ile Phe Gln Asn Ile Thr Thr Gln Ala Thr Gly Thr 
            900                 905                 910 


<210>  135
<211>  2850
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Pro Lys Leu Leu Gln Gly Val Ile Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Gln Tyr Ala Thr Gln His Gly Glu Tyr Asp Thr Leu Asn Lys Ala Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Asn Glu Phe His Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asn Asp Pro Asp Thr Val Asp Ile Ile Leu Gln Ser Leu Asp Arg Asp 
    50                  55                  60                  


His Asn Lys Lys Val Asp Phe Thr Glu Tyr Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Val Gln Ala Arg Asn Lys Ile Ile Gly Lys Asp Tyr Cys Gln Val 
                85                  90                  95      


Ser Gly Ser Lys Leu Arg Asp Asp Thr His Gln His Gln Glu Glu Gln 
            100                 105                 110         


Glu Glu Thr Glu Lys Glu Glu Asn Lys Arg Gln Glu Ser Ser Phe Ser 
        115                 120                 125             


His Ser Ser Trp Ser Ala Gly Glu Asn Asp Ser Tyr Ser Arg Asn Val 
    130                 135                 140                 


Arg Gly Ser Leu Lys Pro Gly Thr Glu Ser Ile Ser Arg Arg Leu Ser 
145                 150                 155                 160 


Phe Gln Arg Asp Phe Ser Gly Gln His Asn Ser Tyr Ser Gly Gln Ser 
                165                 170                 175     


Ser Ser Tyr Gly Glu Gln Asn Ser Asp Ser His Gln Ser Ser Gly Arg 
            180                 185                 190         


Gly Gln Cys Gly Ser Gly Ser Gly Gln Ser Pro Asn Tyr Gly Gln His 
        195                 200                 205             


Gly Ser Gly Ser Gly Gln Ser Ser Ser Asn Asp Thr His Gly Ser Gly 
    210                 215                 220                 


Ser Gly Gln Ser Ser Gly Phe Ser Gln His Lys Ser Ser Ser Gly Gln 
225                 230                 235                 240 


Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser Gly His Ser Ser Gly 
                245                 250                 255     


Tyr Gly Gln His Gly Ser Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg 
            260                 265                 270         


His Arg Ser Ser Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser 
        275                 280                 285             


Gly Ser Arg Gln Ser Leu Gly His Gly Arg Gln Gly Ser Gly Ser Arg 
    290                 295                 300                 


Gln Ser Pro Ser His Val Arg His Gly Ser Gly Ser Gly His Ser Ser 
305                 310                 315                 320 


Ser His Gly Gln His Gly Ser Gly Ser Ser Tyr Ser Tyr Ser Arg Gly 
                325                 330                 335     


His Tyr Glu Ser Gly Ser Gly Gln Thr Ser Gly Phe Gly Gln His Glu 
            340                 345                 350         


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Lys His Gly Ser Gly Ser 
        355                 360                 365             


Gly His Ser Ser Ser Gln Gly Gln His Gly Ser Thr Ser Gly Gln Ala 
    370                 375                 380                 


Ser Ser Ser Gly Gln His Gly Ser Ser Ser Arg Gln Ser Ser Ser Tyr 
385                 390                 395                 400 


Gly Gln His Glu Ser Ala Ser Arg His Ser Ser Gly Arg Gly Gln His 
                405                 410                 415     


Ser Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg Gly Ser Gly 
            420                 425                 430         


Ser Gly Gln Ser Pro Ser Ser Gly Gln His Gly Thr Gly Phe Gly Arg 
        435                 440                 445             


Ser Ser Ser Ser Gly Pro Tyr Val Ser Gly Ser Gly Tyr Ser Ser Gly 
    450                 455                 460                 


Phe Gly His His Glu Ser Ser Ser Glu His Ser Ser Gly Tyr Thr Gln 
465                 470                 475                 480 


His Gly Ser Gly Ser Gly His Ser Ser Gly His Gly Gln His Gly Ser 
                485                 490                 495     


Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg Gln Gly Ser Ser Ala Gly 
            500                 505                 510         


Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln Ser Leu 
        515                 520                 525             


Gly His Ser Arg His Gly Ser Gly Ser Gly Gln Ser Pro Ser Pro Ser 
    530                 535                 540                 


Arg Gly Arg His Glu Ser Gly Ser Arg Gln Ser Ser Ser Tyr Gly Pro 
545                 550                 555                 560 


His Gly Tyr Gly Ser Gly Arg Ser Ser Ser Arg Gly Pro Tyr Glu Ser 
                565                 570                 575     


Gly Ser Gly His Ser Ser Gly Leu Gly His Gln Glu Ser Arg Ser Gly 
            580                 585                 590         


Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly His Ser Ser 
        595                 600                 605             


Thr His Gly Gln His Gly Ser Thr Ser Gly Gln Ser Ser Ser Cys Gly 
    610                 615                 620                 


Gln His Gly Ala Thr Ser Gly Gln Ser Ser Ser His Gly Gln His Gly 
625                 630                 635                 640 


Ser Gly Ser Ser Gln Ser Ser Arg Tyr Gly Gln Gln Gly Ser Gly Ser 
                645                 650                 655     


Gly Gln Ser Pro Ser Arg Gly Arg His Gly Ser Asp Phe Gly His Ser 
            660                 665                 670         


Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Gly Trp Ser Ser Ser Asn 
        675                 680                 685             


Gly Pro His Gly Ser Val Ser Gly Gln Ser Ser Gly Phe Gly His Lys 
    690                 695                 700                 


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser 
705                 710                 715                 720 


Ser His Ser Ser Gly Tyr Arg Lys His Gly Ser Arg Ser Gly Gln Ser 
                725                 730                 735     


Ser Arg Ser Glu Gln His Gly Ser Ser Ser Gly Leu Ser Ser Ser Tyr 
            740                 745                 750         


Gly Gln His Gly Ser Gly Ser His Gln Ser Ser Gly His Gly Arg Gln 
        755                 760                 765             


Gly Ser Gly Ser Gly His Ser Pro Ser Arg Val Arg His Gly Ser Ser 
    770                 775                 780                 


Ser Gly His Ser Ser Ser His Gly Gln His Gly Ser Gly Thr Ser Cys 
785                 790                 795                 800 


Ser Ser Ser Cys Gly His Tyr Glu Ser Gly Ser Gly Gln Ala Ser Gly 
                805                 810                 815     


Phe Gly Gln His Glu Ser Gly Ser Gly Gln Gly Tyr Ser Gln His Gly 
            820                 825                 830         


Ser Ala Ser Gly His Phe Ser Ser Gln Gly Arg His Gly Ser Thr Ser 
        835                 840                 845             


Gly Gln Ser Ser Ser Ser Gly Gln His Asp Ser Ser Ser Gly Gln Ser 
    850                 855                 860                 


Ser Ser Tyr Gly Gln His Glu Ser Ala Ser His His Ala Ser Gly Arg 
865                 870                 875                 880 


Gly Arg His Gly Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg 
                885                 890                 895     


Gly Ser Gly Ser Gly Gln Ser Pro Ser Tyr Gly Arg His Gly Ser Gly 
            900                 905                 910         


Ser Gly Arg Ser Ser Ser Ser Gly Arg His Gly Ser Gly Ser Gly Gln 
        915                 920                 925             


Ser Ser Gly Phe Gly His Lys Ser Ser Ser Gly Gln Ser Ser Gly Tyr 
    930                 935                 940                 


Thr Gln His Gly Ser Gly Ser Gly His Ser Ser Ser Tyr Glu Gln His 
945                 950                 955                 960 


Gly Ser Arg Ser Gly Gln Ser Ser Arg Ser Glu Gln His Gly Ser Ser 
                965                 970                 975     


Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln 
            980                 985                 990         


Ser Leu Gly His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
        995                 1000                 1005             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    1010                 1015                 1020             


Tyr Gly  Pro Tyr Arg Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    1025                 1030                 1035             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    1040                 1045                 1050             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1055                 1060                 1065             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    1070                 1075                 1080             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    1085                 1090                 1095             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    1100                 1105                 1110             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    1115                 1120                 1125             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    1130                 1135                 1140             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    1145                 1150                 1155             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    1160                 1165                 1170             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    1175                 1180                 1185             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    1190                 1195                 1200             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    1205                 1210                 1215             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    1220                 1225                 1230             


Arg Gln  Gly Ser Gly Ser Gly  His Ser Pro Ser Arg  Gly Arg His 
    1235                 1240                 1245             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    1250                 1255                 1260             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser 
    1265                 1270                 1275             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    1280                 1285                 1290             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    1295                 1300                 1305             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    1310                 1315                 1320             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    1325                 1330                 1335             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    1340                 1345                 1350             


Ala Gly  Ser Gly Gln Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly 
    1355                 1360                 1365             


Ser Gly  His Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    1370                 1375                 1380             


Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser 
    1385                 1390                 1395             


Ser Gly  Phe Gly His His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly 
    1400                 1405                 1410             


Cys Thr  Gln His Gly Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu 
    1415                 1420                 1425             


Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His 
    1430                 1435                 1440             


Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser 
    1445                 1450                 1455             


Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln His Gly  Ser Gly Ser 
    1460                 1465                 1470             


Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser 
    1475                 1480                 1485             


Gly Gln  Ser Ser Ser Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp 
    1490                 1495                 1500             


Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly Ser Ser  His Ser Ser 
    1505                 1510                 1515             


Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr 
    1520                 1525                 1530             


Gly Gln  His Gly Ser Ser Ser  Gly His Ser Ser Thr  His Gly Gln 
    1535                 1540                 1545             


His Gly  Ser Thr Ser Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly 
    1550                 1555                 1560             


Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly Gln His  Gly Ser Gly 
    1565                 1570                 1575             


Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly 
    1580                 1585                 1590             


Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser 
    1595                 1600                 1605             


Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser 
    1610                 1615                 1620             


Ser Gly  Gln His Gly Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly 
    1625                 1630                 1635             


His His  Glu Ser Ser Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His 
    1640                 1645                 1650             


Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1655                 1660                 1665             


Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser 
    1670                 1675                 1680             


Arg Ser  Ser Ser Arg Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln 
    1685                 1690                 1695             


Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro 
    1700                 1705                 1710             


Ser Arg  Gly Arg His Gly Ser  Gly Leu Gly His Ser  Ser Ser His 
    1715                 1720                 1725             


Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro 
    1730                 1735                 1740             


Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val Phe Gly  Gln His Glu 
    1745                 1750                 1755             


Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly 
    1760                 1765                 1770             


Ser Gly  His Phe Cys Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly 
    1775                 1780                 1785             


Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser 
    1790                 1795                 1800             


Ser Ser  His Gly Gln His Gly  Ser Gly Ser Ser Gln  Ser Ser Ser 
    1805                 1810                 1815             


Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln Ser Pro  Ser Arg Gly 
    1820                 1825                 1830             


Arg His  Gly Ser Gly Ser Gly  His Ser Ser Ser Tyr  Gly Gln His 
    1835                 1840                 1845             


Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser 
    1850                 1855                 1860             


Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His His Glu  Ser Ser Ser 
    1865                 1870                 1875             


Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly Ser Gly  Ser Gly His 
    1880                 1885                 1890             


Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser 
    1895                 1900                 1905             


Arg Gly  Glu Gln His Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr 
    1910                 1915                 1920             


Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln 
    1925                 1930                 1935             


His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg 
    1940                 1945                 1950             


His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser Tyr Gly  Pro Tyr Gly 
    1955                 1960                 1965             


Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly 
    1970                 1975                 1980             


Ser Gly  His Ser Ser Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly 
    1985                 1990                 1995             


Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser Ser Ser  Gly His Ser 
    2000                 2005                 2010             


Ser Thr  His Gly Gln His Gly  Ser Ala Ser Gly Gln  Ser Ser Ser 
    2015                 2020                 2025             


Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly 
    2030                 2035                 2040             


Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln 
    2045                 2050                 2055             


Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser 
    2060                 2065                 2070             


Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser 
    2075                 2080                 2085             


Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly Pro Gly  Leu Gly Glu 
    2090                 2095                 2100             


Ser Ser  Gly Phe Gly His His  Glu Ser Ser Ser Gly  Gln Ser Ser 
    2105                 2110                 2115             


Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr 
    2120                 2125                 2130             


Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg 
    2135                 2140                 2145             


His Gly  Ser Ser Ser Gly Ser  Ser Ser Arg Tyr Gly  Gln His Gly 
    2150                 2155                 2160             


Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly 
    2165                 2170                 2175             


Ser Gly  His Ser Pro Ser Arg  Gly Arg His Gly Ser  Gly Ser Gly 
    2180                 2185                 2190             


His Ser  Ser Ser His Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser 
    2195                 2200                 2205             


Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val 
    2210                 2215                 2220             


Phe Gly  Gln His Glu Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser 
    2225                 2230                 2235             


Gln His  Gly Ser Gly Ser Gly  His Phe Cys Ser Gln  Gly Gln His 
    2240                 2245                 2250             


Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser 
    2255                 2260                 2265             


Ser Thr  Gly Gln Ser Ser Ser  His Gly Gln His Gly  Ser Gly Ser 
    2270                 2275                 2280             


Ser Gln  Ser Ser Ser Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln 
    2285                 2290                 2295             


Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly Ser Gly  His Ser Ser 
    2300                 2305                 2310             


Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser 
    2315                 2320                 2325             


Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His 
    2330                 2335                 2340             


His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly 
    2345                 2350                 2355             


Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg 
    2360                 2365                 2370             


Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His Gly Ser  Ser Ser Gly 
    2375                 2380                 2385             


Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser 
    2390                 2395                 2400             


Leu Gly  His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
    2405                 2410                 2415             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    2420                 2425                 2430             


Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    2435                 2440                 2445             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    2450                 2455                 2460             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    2465                 2470                 2475             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    2480                 2485                 2490             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    2495                 2500                 2505             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    2510                 2515                 2520             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    2525                 2530                 2535             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    2540                 2545                 2550             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    2555                 2560                 2565             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    2570                 2575                 2580             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    2585                 2590                 2595             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    2600                 2605                 2610             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    2615                 2620                 2625             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    2630                 2635                 2640             


Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro Ser Arg  Gly Arg His 
    2645                 2650                 2655             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    2660                 2665                 2670             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Leu 
    2675                 2680                 2685             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    2690                 2695                 2700             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    2705                 2710                 2715             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    2720                 2725                 2730             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    2735                 2740                 2745             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    2750                 2755                 2760             


Ala Gly  Ser Gly Gln Ser Leu  Ser His Gly Arg His  Gly Ser Gly 
    2765                 2770                 2775             


Ser Gly  Gln Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    2780                 2785                 2790             


Gln Ser  Ser Gly Tyr Ser Gln  His Gly Ser Gly Ser  Gly Gln Asp 
    2795                 2800                 2805             


Gly Tyr  Ser Tyr Cys Lys Gly  Gly Ser Asn His Asp  Gly Gly Ser 
    2810                 2815                 2820             


Ser Gly  Ser Tyr Phe Leu Ser  Phe Pro Ser Ser Thr  Ser Pro Tyr 
    2825                 2830                 2835             


Glu Tyr  Val Gln Glu Gln Arg  Cys Tyr Phe Tyr Gln  
    2840                 2845                 2850 


<210>  136
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 


<210>  137
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Ser Asn Val Thr Asn Lys Thr Asp Pro Arg Ser Met Asn Ser 
1               5                   10                  15      


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30          


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys Ser Val 
        35                  40                  45              


His Lys Gly Phe Ala Phe Val Gln Tyr Val Asn Glu Arg Asn Ala Arg 
    50                  55                  60                  


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Gly Gln Val Leu 
65                  70                  75                  80  


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Lys Ala Gly 
                85                  90                  95      


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Val Thr Glu His Pro 
            100                 105                 110         


Ser Pro Ser Pro Leu Leu Ser Ser Ser Phe Asp Leu Asp Tyr Asp Phe 
        115                 120                 125             


Gln Arg Asp Tyr Tyr Asp Arg Met Tyr Ser Tyr Pro Ala Arg Val Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ile Ala Arg Ala Val Val Pro Ser Lys Arg Gln Arg 
145                 150                 155                 160 


Val Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe Asn Ser Lys 
                165                 170                 175     


Ser Gly Gln Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys Gly Asp Asp 
            180                 185                 190         


Leu Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp 
        195                 200                 205             


Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln Ser Lys Gln 
    210                 215                 220                 


Ala Val Glu Met Lys Asn Asp Lys Ser Glu Glu Glu Gln Ser Ser Ser 
225                 230                 235                 240 


Ser Val Lys Lys Asp Glu Thr Asn Val Lys Met Glu Ser Glu Gly Gly 
                245                 250                 255     


Ala Asp Asp Ser Ala Glu Glu Gly Asp Leu Leu Asp Asp Asp Asp Asn 
            260                 265                 270         


Glu Asp Arg Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp Asp Glu Lys 
        275                 280                 285             


Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Ala Asn Gly Glu Asp 
    290                 295                 300                 


Asp Ser 
305     


<210>  138
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Asn Val Thr Ser Ile Ala Leu Arg Ala Glu Thr Trp Leu Leu Ala 
1               5                   10                  15      


Ala Trp His Val Lys Val Pro Pro Met Trp Leu Glu Ala Cys Ile Asn 
            20                  25                  30          


Trp Ile Gln Glu Glu Asn Asn Asn Val Asn Leu Ser Gln Ala Gln Met 
        35                  40                  45              


Asn Lys Gln Val Phe Glu Gln Trp Leu Leu Thr Asp Leu Arg Asp Leu 
    50                  55                  60                  


Glu His Pro Leu Leu Pro Asp Gly Ile Leu Glu Ile Pro Lys Gly Glu 
65                  70                  75                  80  


Leu Asn Gly Phe Tyr Ala Leu Gln Ile Asn Ser Leu Val Asp Val Ser 
                85                  90                  95      


Gln Pro Ala Tyr Ser Gln Ile Gln Lys Leu Arg Gly Lys Asn Thr Thr 
            100                 105                 110         


Asn Asp Leu Val Thr Ala Glu Ala Gln Val Thr Pro Lys Pro Trp Glu 
        115                 120                 125             


Ala Lys Pro Ser Arg Met Leu Met Leu Gln Leu Thr Asp Gly Ile Val 
    130                 135                 140                 


Gln Ile Gln Gly Met Glu Tyr Gln Pro Ile Pro Ile Leu His Ser Asp 
145                 150                 155                 160 


Leu Pro Pro Gly Thr Lys Ile Leu Ile Tyr Gly Asn Ile Ser Phe Arg 
                165                 170                 175     


Leu Gly Val Leu Leu Leu Lys Pro Glu Asn Val Lys Val Leu Gly Gly 
            180                 185                 190         


Glu Val Asp Ala Leu Leu Glu Glu Tyr Ala Gln Glu Lys Val Leu Ala 
        195                 200                 205             


Arg Leu Ile Gly Glu Pro Asp Leu Val Val Ser Val Ile Pro Asn Asn 
    210                 215                 220                 


Ser Asn Glu Asn Ile Pro Arg Val Thr Asp Val Leu Asp Pro Ala Leu 
225                 230                 235                 240 


Gly Pro Ser Asp Glu Glu Leu Leu Ala Ser Leu Asp Glu Asn Asp Glu 
                245                 250                 255     


Leu Thr Ala Asn Asn Asp Thr Ser Ser Glu Arg Cys Phe Thr Thr Gly 
            260                 265                 270         


Ser Ser Ser Asn Thr Ile Pro Thr Arg Gln Ser Ser Phe Glu Pro Glu 
        275                 280                 285             


Phe Val Ile Ser Pro Arg Pro Lys Glu Glu Pro Ser Asn Leu Ser Ile 
    290                 295                 300                 


His Val Met Asp Gly Glu Leu Asp Asp Phe Ser Leu Glu Glu Ala Leu 
305                 310                 315                 320 


Leu Leu Glu Glu Thr Val Gln Lys Glu Gln Met Glu Thr Lys Glu Leu 
                325                 330                 335     


Gln Pro Leu Thr Phe Asn Arg Asn Ala Asp Arg Ser Ile Glu Arg Phe 
            340                 345                 350         


Ser His Asn Pro Asn Thr Thr Asn Asn Phe Ser Leu Thr Cys Lys Asn 
        355                 360                 365             


Gly Asn Asn Asn Trp Ser Glu Lys Asn Val Ser Glu Gln Met Thr Asn 
    370                 375                 380                 


Glu Asp Lys Ser Phe Gly Cys Pro Ser Val Arg Asp Gln Asn Arg Ser 
385                 390                 395                 400 


Ile Phe Ser Val His Cys Asn Val Pro Leu Ala His Asp Phe Thr Asn 
                405                 410                 415     


Lys Glu Lys Asn Leu Glu Thr Asp Asn Lys Ile Lys Gln Thr Ser Ser 
            420                 425                 430         


Ser Asp Ser His Ser Leu Asn Asn Lys Ile Leu Asn Arg Glu Val Val 
        435                 440                 445             


Asn Tyr Val Gln Lys Arg Asn Ser Gln Ile Ser Asn Glu Asn Asp Cys 
    450                 455                 460                 


Asn Leu Gln Ser Cys Ser Leu Arg Ser Ser Glu Asn Ser Ile Asn Leu 
465                 470                 475                 480 


Ser Ile Ala Met Asp Leu Tyr Ser Pro Pro Phe Val Tyr Leu Ser Val 
                485                 490                 495     


Leu Met Ala Ser Lys Pro Lys Glu Val Thr Thr Val Lys Val Lys Ala 
            500                 505                 510         


Phe Ile Val Thr Leu Thr Gly Asn Leu Ser Ser Ser Gly Gly Ile Trp 
        515                 520                 525             


Ser Ile Thr Ala Lys Val Ser Asp Gly Thr Ala Tyr Leu Asp Val Asp 
    530                 535                 540                 


Phe Val Asp Glu Ile Leu Thr Ser Leu Ile Gly Phe Ser Val Pro Glu 
545                 550                 555                 560 


Met Lys Gln Ser Lys Lys Asp Pro Leu Gln Tyr Gln Lys Phe Leu Glu 
                565                 570                 575     


Gly Leu Gln Lys Cys Gln Arg Asp Leu Ile Asp Leu Cys Cys Leu Met 
            580                 585                 590         


Thr Ile Ser Phe Asn Pro Ser Leu Ser Lys Ala Met Val Leu Ala Leu 
        595                 600                 605             


Gln Asp Val Asn Met Glu His Leu Glu Asn Leu Lys Lys Arg Leu Asn 
    610                 615                 620                 


Lys 
625 


<210>  139
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Lys Val Tyr 
            820                 825                 830         


Leu Cys Gly Gln Asp Glu Glu His Lys His Cys Glu Asp Tyr Val Cys 
        835                 840                 845             


Ser Tyr Asn Tyr Glu Gly Lys Gly Ser Leu Ala Gly Ser Val Gly Cys 
    850                 855                 860                 


Cys Ser Asp Arg Gln Glu Glu Glu Gly Leu Glu Phe Leu Asp His Leu 
865                 870                 875                 880 


Glu Pro Lys Phe Arg Thr Leu Ala Lys Thr Cys Ile Lys Lys 
                885                 890                 


<210>  140
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Ala Ala Thr Gly Pro Ser Phe Trp Leu Gly Asn Glu Thr Leu 
1               5                   10                  15      


Lys Val Pro Leu Ala Leu Phe Ala Leu Asn Arg Gln Arg Leu Cys Glu 
            20                  25                  30          


Arg Leu Arg Lys Asn Pro Ala Val Gln Ala Gly Ser Ile Val Val Leu 
        35                  40                  45              


Gln Gly Gly Glu Glu Thr Gln Arg Tyr Cys Thr Asp Thr Gly Val Leu 
    50                  55                  60                  


Phe Arg Gln Glu Ser Phe Phe His Trp Ala Phe Gly Val Thr Glu Pro 
65                  70                  75                  80  


Gly Cys Tyr Gly Val Ile Asp Val Asp Thr Gly Lys Ser Thr Leu Phe 
                85                  90                  95      


Val Pro Arg Leu Pro Ala Ser His Ala Thr Trp Met Gly Lys Ile His 
            100                 105                 110         


Ser Lys Glu His Phe Lys Glu Lys Tyr Ala Val Asp Asp Val Gln Tyr 
        115                 120                 125             


Val Asp Glu Ile Ala Ser Val Leu Thr Ser Gln Lys Pro Ser Val Leu 
    130                 135                 140                 


Leu Thr Leu Arg Gly Val Asn Thr Asp Ser Gly Ser Val Cys Arg Glu 
145                 150                 155                 160 


Ala Ser Phe Asp Gly Ile Ser Lys Phe Glu Val Asn Asn Thr Ile Leu 
                165                 170                 175     


His Pro Glu Ile Val Glu Cys Arg Val Phe Lys Thr Asp Met Glu Leu 
            180                 185                 190         


Glu Val Leu Arg Tyr Thr Asn Lys Ile Ser Ser Glu Ala His Arg Glu 
        195                 200                 205             


Val Met Lys Ala Val Lys Val Gly Met Lys Glu Tyr Glu Leu Glu Ser 
    210                 215                 220                 


Leu Phe Glu His Tyr Cys Tyr Ser Arg Gly Gly Met Arg His Ser Ser 
225                 230                 235                 240 


Tyr Thr Cys Ile Cys Gly Ser Gly Glu Asn Ser Ala Val Leu His Tyr 
                245                 250                 255     


Gly His Ala Gly Ala Pro Asn Asp Arg Thr Ile Gln Asn Gly Asp Met 
            260                 265                 270         


Cys Leu Phe Asp Met Gly Gly Glu Tyr Tyr Cys Phe Ala Ser Asp Ile 
        275                 280                 285             


Thr Cys Ser Phe Pro Ala Asn Gly Lys Phe Thr Ala Asp Gln Lys Ala 
    290                 295                 300                 


Val Tyr Glu Ala Val Leu Arg Ser Ser Arg Ala Val Met Gly Ala Met 
305                 310                 315                 320 


Lys Pro Gly Val Trp Trp Pro Asp Met His Arg Leu Ala Asp Arg Ile 
                325                 330                 335     


His Leu Glu Glu Leu Ala His Met Gly Ile Leu Ser Gly Ser Val Asp 
            340                 345                 350         


Ala Met Val Gln Ala His Leu Gly Ala Val Phe Met Pro His Gly Leu 
        355                 360                 365             


Gly His Phe Leu Gly Ile Asp Val His Asp Val Gly Gly Tyr Pro Glu 
    370                 375                 380                 


Gly Val Glu Arg Ile Asp Glu Pro Gly Leu Arg Ser Leu Arg Thr Ala 
385                 390                 395                 400 


Arg His Leu Gln Pro Gly Met Val Leu Thr Val Glu Pro Gly Ile Tyr 
                405                 410                 415     


Phe Ile Asp His Leu Leu Asp Glu Ala Leu Ala Asp Pro Ala Arg Ala 
            420                 425                 430         


Ser Phe Leu Asn Arg Glu Val Leu Gln Arg Phe Arg Gly Phe Gly Gly 
        435                 440                 445             


Val Arg Ile Glu Glu Asp Val Val Val Thr Asp Ser Gly Ile Glu Leu 
    450                 455                 460                 


Leu Thr Cys Val Pro Arg Thr Val Glu Glu Ile Glu Ala Cys Met Ala 
465                 470                 475                 480 


Gly Cys Asp Lys Ala Phe Thr Pro Phe Ser Gly Pro Lys 
                485                 490             


<210>  141
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Glu Val Met Asn Leu Met Glu Gln Pro Ile Lys Val Thr Glu Trp 
1               5                   10                  15      


Gln Gln Thr Tyr Thr Tyr Asp Ser Gly Ile His Ser Gly Ala Asn Thr 
            20                  25                  30          


Cys Val Pro Ser Val Ser Ser Lys Gly Ile Met Glu Glu Asp Glu Ala 
        35                  40                  45              


Cys Gly Arg Gln Tyr Thr Leu Lys Lys Thr Thr Thr Tyr Thr Gln Gly 
    50                  55                  60                  


Val Pro Pro Ser Gln Gly Asp Leu Glu Tyr Gln Met Ser Thr Thr Ala 
65                  70                  75                  80  


Arg Ala Lys Arg Val Arg Glu Ala Met Cys Pro Gly Val Ser Gly Glu 
                85                  90                  95      


Asp Ser Ser Leu Leu Leu Ala Thr Gln Val Glu Gly Gln Ala Thr Asn 
            100                 105                 110         


Leu Gln Arg Leu Ala Glu Pro Ser Gln Leu Leu Lys Ser Ala Ile Val 
        115                 120                 125             


His Leu Ile Asn Tyr Gln Asp Asp Ala Glu Leu Ala Thr Arg Ala Leu 
    130                 135                 140                 


Pro Glu Leu Thr Lys Leu Leu Asn Asp Glu Asp Pro Val Val Val Thr 
145                 150                 155                 160 


Lys Ala Ala Met Ile Val Asn Gln Leu Ser Lys Lys Glu Ala Ser Arg 
                165                 170                 175     


Arg Ala Leu Met Gly Ser Pro Gln Leu Val Ala Ala Val Val Arg Thr 
            180                 185                 190         


Met Gln Asn Thr Ser Asp Leu Asp Thr Ala Arg Cys Thr Thr Ser Ile 
        195                 200                 205             


Leu His Asn Leu Ser His His Arg Glu Gly Leu Leu Ala Ile Phe Lys 
    210                 215                 220                 


Ser Gly Gly Ile Pro Ala Leu Val Arg Met Leu Ser Ser Pro Val Glu 
225                 230                 235                 240 


Ser Val Leu Phe Tyr Ala Ile Thr Thr Leu His Asn Leu Leu Leu Tyr 
                245                 250                 255     


Gln Glu Gly Ala Lys Met Ala Val Arg Leu Ala Asp Gly Leu Gln Lys 
            260                 265                 270         


Met Val Pro Leu Leu Asn Lys Asn Asn Pro Lys Phe Leu Ala Ile Thr 
        275                 280                 285             


Thr Asp Cys Leu Gln Leu Leu Ala Tyr Gly Asn Gln Glu Ser Lys Leu 
    290                 295                 300                 


Ile Ile Leu Ala Asn Gly Gly Pro Gln Ala Leu Val Gln Ile Met Arg 
305                 310                 315                 320 


Asn Tyr Ser Tyr Glu Lys Leu Leu Trp Thr Thr Ser Arg Val Leu Lys 
                325                 330                 335     


Val Leu Ser Val Cys Pro Ser Asn Lys Pro Ala Ile Val Glu Ala Gly 
            340                 345                 350         


Gly Met Gln Ala Leu Gly Lys His Leu Thr Ser Asn Ser Pro Arg Leu 
        355                 360                 365             


Val Gln Asn Cys Leu Trp Thr Leu Arg Asn Leu Ser Asp Val Ala Thr 
    370                 375                 380                 


Lys Gln Glu Gly Leu Glu Ser Val Leu Lys Ile Leu Val Asn Gln Leu 
385                 390                 395                 400 


Ser Val Asp Asp Val Asn Val Leu Thr Cys Ala Thr Gly Thr Leu Ser 
                405                 410                 415     


Asn Leu Thr Cys Asn Asn Ser Lys Asn Lys Thr Leu Val Thr Gln Asn 
            420                 425                 430         


Ser Gly Val Glu Ala Leu Ile His Ala Ile Leu Arg Ala Gly Asp Lys 
        435                 440                 445             


Asp Asp Ile Thr Glu Pro Ala Val Cys Ala Leu Arg His Leu Thr Ser 
    450                 455                 460                 


Arg His Pro Glu Ala Glu Met Ala Gln Asn Ser Val Arg Leu Asn Tyr 
465                 470                 475                 480 


Gly Ile Pro Ala Ile Val Lys Leu Leu Asn Gln Pro Asn Gln Trp Pro 
                485                 490                 495     


Leu Val Lys Ala Thr Ile Gly Leu Ile Arg Asn Leu Ala Leu Cys Pro 
            500                 505                 510         


Ala Asn His Ala Pro Leu Gln Glu Ala Ala Val Ile Pro Arg Leu Val 
        515                 520                 525             


Gln Leu Leu Val Lys Ala His Gln Asp Ala Gln Arg His Val Ala Ala 
    530                 535                 540                 


Gly Thr Gln Gln Pro Tyr Thr Asp Gly Val Arg Met Glu Glu Ile Val 
545                 550                 555                 560 


Glu Gly Cys Thr Gly Ala Leu His Ile Leu Ala Arg Asp Pro Met Asn 
                565                 570                 575     


Arg Met Glu Ile Phe Arg Leu Asn Thr Ile Pro Leu Phe Val Gln Leu 
            580                 585                 590         


Leu Tyr Ser Ser Val Glu Asn Ile Gln Arg Val Ala Ala Gly Val Leu 
        595                 600                 605             


Cys Glu Leu Ala Gln Asp Lys Glu Ala Ala Asp Ala Ile Asp Ala Glu 
    610                 615                 620                 


Gly Ala Ser Ala Pro Leu Met Glu Leu Leu His Ser Arg Asn Glu Gly 
625                 630                 635                 640 


Thr Ala Thr Tyr Ala Ala Ala Val Leu Phe Arg Ile Ser Glu Asp Lys 
                645                 650                 655     


Asn Pro Asp Tyr Arg Lys Arg Val Ser Val Glu Leu Thr Asn Ser Leu 
            660                 665                 670         


Phe Lys His Asp Pro Ala Ala Trp Glu Ala Ala Gln Ser Met Ile Pro 
        675                 680                 685             


Ile Asn Glu Pro Tyr Gly Asp Asp Met Asp Ala Thr Tyr Arg Pro Met 
    690                 695                 700                 


Tyr Ser Ser Asp Val Pro Leu Asp Pro Leu Glu Met His Met Asp Met 
705                 710                 715                 720 


Asp Gly Asp Tyr Pro Ile Asp Thr Tyr Ser Asp Gly Leu Arg Pro Pro 
                725                 730                 735     


Tyr Pro Thr Ala Asp His Met Leu Ala 
            740                 745 


<210>  142
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Asn Val Asn Gln Val Ala Glu Asn Leu Ala Leu Ser His Gln Glu 
1               5                   10                  15      


Glu Leu Val Asp Leu Pro Lys Asn Tyr Pro Leu Ser Glu Asn Glu Asp 
            20                  25                  30          


Glu Gly Asp Ser Asp Gly Glu Arg Lys His Gln Lys Leu Leu Glu Ala 
        35                  40                  45              


Ile Ile Ser Leu Asp Gly Lys Asn Arg Arg Lys Leu Ala Glu Arg Ser 
    50                  55                  60                  


Glu Ala Ser Leu Lys Val Ser Glu Phe Ser Val Ser Ser Glu Gly Ser 
65                  70                  75                  80  


Gly Glu Lys Leu Gly Leu Ala Asp Leu Leu Glu Pro Val Lys Thr Ser 
                85                  90                  95      


Ser Ser Leu Ala Thr Val Lys Lys Gln Leu Asn Arg Val Lys Ser Lys 
            100                 105                 110         


Lys Val Val Glu Leu Pro Leu Asn Lys Glu Lys Ile Glu Gln Ile His 
        115                 120                 125             


Arg Glu Val Ala Phe Ser Lys Thr Ser Gln Val Leu Ser Lys Trp Asp 
    130                 135                 140                 


Pro Ile Ile Leu Lys Asn Gln Gln Ala Glu Gln Leu Val Phe Pro Leu 
145                 150                 155                 160 


Gly Lys Glu Gln Pro Ala Ile Ala Pro Ile Glu His Ala Leu Ser Gly 
                165                 170                 175     


Trp Lys Ala Arg Thr Pro Leu Glu Gln Glu Ile Phe Asn Leu Leu His 
            180                 185                 190         


Lys Asn Lys Gln Pro Val Thr Asp Pro Leu Leu Thr Pro Met Glu Lys 
        195                 200                 205             


Ala Ser Leu Gln Ala Met Ser Leu Glu Glu Ala Lys Met His Arg Ala 
    210                 215                 220                 


Glu Leu Gln Arg Ala Arg Ala Leu Gln Ser Tyr Tyr Glu Ala Lys Ala 
225                 230                 235                 240 


Arg Lys Glu Lys Lys Ile Lys Ser Lys Lys Tyr His Lys Val Val Lys 
                245                 250                 255     


Lys Gly Lys Ala Lys Lys Ala Leu Lys Glu Phe Glu Gln Leu Gln Lys 
            260                 265                 270         


Val Asn Pro Thr Val Ala Leu Glu Glu Met Glu Lys Ile Glu Asn Ala 
        275                 280                 285             


Arg Met Met Glu Arg Met Ser Leu Lys His Gln Asn Ser Gly Lys Trp 
    290                 295                 300                 


Ala Lys Ser Lys Ala Ile Met Ala Lys Tyr Asp Leu Glu Ala Arg Gln 
305                 310                 315                 320 


Ala Met Gln Glu Gln Leu Ala Lys Asn Lys Glu Leu Thr Gln Lys Leu 
                325                 330                 335     


Gln Val Ala Ser Glu Ser Glu Glu Glu Glu Gly Gly Thr Glu Val Glu 
            340                 345                 350         


Glu Leu Leu Val Pro His Val Ala Asn Glu Val Gln Met Asn Val Asp 
        355                 360                 365             


Gly Pro Asn Pro Trp Met Phe Arg Ser Cys Thr Ser Asp Thr Lys Glu 
    370                 375                 380                 


Ala Ala Thr Gln Glu Asp Pro Glu Gln Val Pro Glu Leu Ala Ala His 
385                 390                 395                 400 


Glu Val Ser Ala Ser Glu Ala Glu Glu Arg Pro Val Ala Glu Glu Glu 
                405                 410                 415     


Ile Leu Leu Arg Glu Phe Glu Glu Arg Gln Ser Leu Arg Lys Arg Ser 
            420                 425                 430         


Glu Leu Asn Gln Asp Ala Glu Pro Ala Ser Ser Gln Glu Thr Lys Asp 
        435                 440                 445             


Ser Ser Ser Gln Glu Val Leu Ser Glu Leu Arg Ala Leu Ser Gln Lys 
    450                 455                 460                 


Leu Lys Glu Lys His Gln Ser Arg Lys Gln Lys Ala Ser Ser Glu Gly 
465                 470                 475                 480 


Thr Val Pro Gln Val Gln Arg Glu Glu Pro Ala Pro Glu Glu Ala Glu 
                485                 490                 495     


Pro Leu Leu Leu Gln Arg Ser Glu Arg Val Gln Thr Leu Glu Glu Leu 
            500                 505                 510         


Glu Glu Leu Gly Lys Glu Asp Cys Phe Gln Asn Lys Glu Leu Pro Arg 
        515                 520                 525             


Pro Val Leu Glu Gly Gln Gln Ser Glu Arg Thr Pro Asn Asn Arg Pro 
    530                 535                 540                 


Asp Ala Pro Lys Glu Lys Lys Glu Lys Glu Gln Leu Ile Asn Leu Gln 
545                 550                 555                 560 


Asn Phe Leu Thr Thr Gln Ser Pro Ser Val Arg Ser Leu Ala Val Pro 
                565                 570                 575     


Thr Ile Ile Glu Glu Leu Glu Asp Glu Glu Glu Arg Asp Gln Arg Gln 
            580                 585                 590         


Met Ile Lys Glu Ala Phe Ala Gly Asp Asp Val Ile Arg Asp Phe Leu 
        595                 600                 605             


Lys Glu Lys Arg Glu Ala Val Glu Ala Ser Lys Pro Lys Asp Val Asp 
    610                 615                 620                 


Leu Thr Leu Pro Gly Trp Gly Glu Trp Gly Gly Val Gly Leu Lys Pro 
625                 630                 635                 640 


Ser Ala Lys Lys Arg Arg Gln Phe Leu Ile Lys Ala Pro Glu Gly Pro 
                645                 650                 655     


Pro Arg Lys Asp Lys Asn Leu Pro Asn Val Ile Ile Ser Glu Lys Arg 
            660                 665                 670         


Asn Ile His Ala Ala Ala His Gln Val Gln Val Leu Pro Tyr Pro Phe 
        675                 680                 685             


Thr His His Arg Gln Phe Glu Arg Thr Ile Gln Thr Pro Ile Gly Ser 
    690                 695                 700                 


Thr Trp Asn Thr Gln Arg Ala Phe Gln Lys Leu Thr Thr Pro Lys Val 
705                 710                 715                 720 


Val Thr Lys Pro Gly His Ile Ile Lys Pro Ile Lys Ala Glu Asp Val 
                725                 730                 735     


Gly Tyr Gln Ser Ser Ser Arg Ser Asp Leu Pro Val Ile Gln Arg Asn 
            740                 745                 750         


Pro Lys Arg Ile Thr Thr Arg His Asn Lys Glu Glu Lys Leu 
        755                 760                 765     


<210>  143
<211>  7968
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro 
1               5                   10                  15      


Lys Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Cys Gln 
            20                  25                  30          


Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln 
        35                  40                  45              


Pro Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu 
    50                  55                  60                  


Tyr Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr 
65                  70                  75                  80  


Val Cys Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Ala Val Gly 
                85                  90                  95      


Leu Gln Val Asp Ala Glu Ala Ala Cys Ala Glu Gln Ala Pro His Phe 
            100                 105                 110         


Leu Leu Arg Pro Thr Ser Ile Arg Val Arg Glu Gly Ser Glu Ala Thr 
        115                 120                 125             


Phe Arg Cys Arg Val Gly Gly Ser Pro Arg Pro Ala Val Ser Trp Ser 
    130                 135                 140                 


Lys Asp Gly Arg Arg Leu Gly Glu Pro Asp Gly Pro Arg Val Arg Val 
145                 150                 155                 160 


Glu Glu Leu Gly Glu Ala Ser Ala Leu Arg Ile Arg Ala Ala Arg Pro 
                165                 170                 175     


Arg Asp Gly Gly Thr Tyr Glu Val Arg Ala Glu Asn Pro Leu Gly Ala 
            180                 185                 190         


Ala Ser Ala Ala Ala Ala Leu Val Val Asp Ser Asp Ala Ala Asp Thr 
        195                 200                 205             


Ala Ser Arg Pro Gly Thr Ser Thr Ala Ala Leu Leu Ala His Leu Gln 
    210                 215                 220                 


Arg Arg Arg Glu Ala Met Arg Ala Glu Gly Ala Pro Ala Ser Pro Pro 
225                 230                 235                 240 


Ser Thr Gly Thr Arg Thr Cys Thr Val Thr Glu Gly Lys His Ala Arg 
                245                 250                 255     


Leu Ser Cys Tyr Val Thr Gly Glu Pro Lys Pro Glu Thr Val Trp Lys 
            260                 265                 270         


Lys Asp Gly Gln Leu Val Thr Glu Gly Arg Arg His Val Val Tyr Glu 
        275                 280                 285             


Asp Ala Gln Glu Asn Phe Val Leu Lys Ile Leu Phe Cys Lys Gln Ser 
    290                 295                 300                 


Asp Arg Gly Leu Tyr Thr Cys Thr Ala Ser Asn Leu Val Gly Gln Thr 
305                 310                 315                 320 


Tyr Ser Ser Val Leu Val Val Val Arg Glu Pro Ala Val Pro Phe Lys 
                325                 330                 335     


Lys Arg Leu Gln Asp Leu Glu Val Arg Glu Lys Glu Ser Ala Thr Phe 
            340                 345                 350         


Leu Cys Glu Val Pro Gln Pro Ser Thr Glu Ala Ala Trp Phe Lys Glu 
        355                 360                 365             


Glu Thr Arg Leu Trp Ala Ser Ala Lys Tyr Gly Ile Glu Glu Glu Gly 
    370                 375                 380                 


Thr Glu Arg Arg Leu Thr Val Arg Asn Val Ser Ala Asp Asp Asp Ala 
385                 390                 395                 400 


Val Tyr Ile Cys Glu Thr Pro Glu Gly Ser Arg Thr Val Ala Glu Leu 
                405                 410                 415     


Ala Val Gln Gly Asn Leu Leu Arg Lys Leu Pro Arg Lys Thr Ala Val 
            420                 425                 430         


Arg Val Gly Asp Thr Ala Met Phe Cys Val Glu Leu Ala Val Pro Val 
        435                 440                 445             


Gly Pro Val His Trp Leu Arg Asn Gln Glu Glu Val Val Ala Gly Gly 
    450                 455                 460                 


Arg Val Ala Ile Ser Ala Glu Gly Thr Arg His Thr Leu Thr Ile Ser 
465                 470                 475                 480 


Gln Cys Cys Leu Glu Asp Val Gly Gln Val Ala Phe Met Ala Gly Asp 
                485                 490                 495     


Cys Gln Thr Ser Thr Gln Phe Cys Val Ser Ala Pro Arg Lys Pro Pro 
            500                 505                 510         


Leu Gln Pro Pro Val Asp Pro Val Val Lys Ala Arg Met Glu Ser Ser 
        515                 520                 525             


Val Ile Leu Ser Trp Ser Pro Pro Pro His Gly Glu Arg Pro Val Thr 
    530                 535                 540                 


Ile Asp Gly Tyr Leu Val Glu Lys Lys Lys Leu Gly Thr Tyr Thr Trp 
545                 550                 555                 560 


Ile Arg Cys His Glu Ala Glu Trp Val Ala Thr Pro Glu Leu Thr Val 
                565                 570                 575     


Ala Asp Val Ala Glu Glu Gly Asn Phe Gln Phe Arg Val Ser Ala Leu 
            580                 585                 590         


Asn Ser Phe Gly Gln Ser Pro Tyr Leu Glu Phe Pro Gly Thr Val His 
        595                 600                 605             


Leu Ala Pro Lys Leu Ala Val Arg Thr Pro Leu Lys Ala Val Gln Ala 
    610                 615                 620                 


Val Glu Gly Gly Glu Val Thr Phe Ser Val Asp Leu Thr Val Ala Ser 
625                 630                 635                 640 


Ala Gly Glu Trp Phe Leu Asp Gly Gln Ala Leu Lys Ala Ser Ser Val 
                645                 650                 655     


Tyr Glu Ile His Cys Asp Arg Thr Arg His Thr Leu Thr Ile Arg Glu 
            660                 665                 670         


Val Pro Ala Ser Leu His Gly Ala Gln Leu Lys Phe Val Ala Asn Gly 
        675                 680                 685             


Ile Glu Ser Ser Ile Arg Met Glu Val Arg Ala Ala Pro Gly Leu Thr 
    690                 695                 700                 


Ala Asn Lys Pro Pro Ala Ala Ala Ala Arg Glu Val Leu Ala Arg Leu 
705                 710                 715                 720 


His Glu Glu Ala Gln Leu Leu Ala Glu Leu Ser Asp Gln Ala Ala Ala 
                725                 730                 735     


Val Thr Trp Leu Lys Asp Gly Arg Thr Leu Ser Pro Gly Pro Lys Tyr 
            740                 745                 750         


Glu Val Gln Ala Ser Ala Gly Arg Arg Val Leu Leu Val Arg Asp Val 
        755                 760                 765             


Ala Arg Asp Asp Ala Gly Leu Tyr Glu Cys Val Ser Arg Gly Gly Arg 
    770                 775                 780                 


Ile Ala Tyr Gln Leu Ser Val Gln Gly Leu Ala Arg Phe Leu His Lys 
785                 790                 795                 800 


Asp Met Ala Gly Ser Cys Val Asp Ala Val Ala Gly Gly Pro Ala Gln 
                805                 810                 815     


Phe Glu Cys Glu Thr Ser Glu Ala His Val His Val His Trp Tyr Lys 
            820                 825                 830         


Asp Gly Met Glu Leu Gly His Ser Gly Glu Arg Phe Leu Gln Glu Asp 
        835                 840                 845             


Val Gly Thr Arg His Arg Leu Val Ala Ala Thr Val Thr Arg Gln Asp 
    850                 855                 860                 


Glu Gly Thr Tyr Ser Cys Arg Val Gly Glu Asp Ser Val Asp Phe Arg 
865                 870                 875                 880 


Leu Arg Val Ser Glu Pro Lys Val Val Phe Ala Lys Glu Gln Leu Ala 
                885                 890                 895     


Arg Arg Lys Leu Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys 
            900                 905                 910         


Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys 
        915                 920                 925             


Lys Leu Ser Ser Ser Ser Lys Val Cys Met Glu Ala Thr Gly Cys Thr 
    930                 935                 940                 


Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr 
945                 950                 955                 960 


Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Lys 
                965                 970                 975     


Glu Pro Lys Val Val Phe Ala Lys Asp Gln Val Ala His Ser Glu Val 
            980                 985                 990         


Gln Ala Glu Ala Gly Ala Ser Ala  Thr Leu Ser Cys Glu  Val Ala Gln 
        995                 1000                 1005             


Ala Gln  Thr Glu Val Met Trp  Tyr Lys Asp Gly Lys  Lys Leu Ser 
    1010                 1015                 1020             


Ser Ser  Leu Lys Val His Val  Glu Ala Lys Gly Cys  Arg Arg Arg 
    1025                 1030                 1035             


Leu Val  Val Gln Gln Ala Gly  Lys Thr Asp Ala Gly  Asp Tyr Ser 
    1040                 1045                 1050             


Cys Glu  Ala Arg Gly Gln Arg  Val Ser Phe Arg Leu  His Ile Thr 
    1055                 1060                 1065             


Glu Pro  Lys Met Met Phe Ala  Lys Glu Gln Ser Val  His Asn Glu 
    1070                 1075                 1080             


Val Gln  Ala Glu Ala Gly Ala  Ser Ala Met Leu Ser  Cys Glu Val 
    1085                 1090                 1095             


Ala Gln  Ala Gln Thr Glu Val  Thr Trp Tyr Lys Asp  Gly Lys Lys 
    1100                 1105                 1110             


Leu Ser  Ser Ser Ser Lys Val  Gly Met Glu Val Lys  Gly Cys Thr 
    1115                 1120                 1125             


Arg Arg  Leu Val Leu Pro Gln  Ala Gly Lys Ala Asp  Ala Gly Glu 
    1130                 1135                 1140             


Tyr Ser  Cys Glu Ala Gly Gly  Gln Arg Val Ser Phe  His Leu His 
    1145                 1150                 1155             


Ile Thr  Glu Pro Lys Gly Val  Phe Ala Lys Glu Gln  Ser Val His 
    1160                 1165                 1170             


Asn Glu  Val Gln Ala Glu Ala  Gly Thr Thr Ala Met  Leu Ser Cys 
    1175                 1180                 1185             


Glu Val  Ala Gln Pro Gln Thr  Glu Val Thr Trp Tyr  Lys Asp Gly 
    1190                 1195                 1200             


Lys Lys  Leu Ser Ser Ser Ser  Lys Val Arg Met Glu  Val Lys Gly 
    1205                 1210                 1215             


Cys Thr  Arg Arg Leu Val Val  Gln Gln Val Gly Lys  Ala Asp Ala 
    1220                 1225                 1230             


Gly Glu  Tyr Ser Cys Glu Ala  Gly Gly Gln Arg Val  Ser Phe Gln 
    1235                 1240                 1245             


Leu His  Ile Thr Glu Pro Lys  Ala Val Phe Ala Lys  Glu Gln Leu 
    1250                 1255                 1260             


Val His  Asn Glu Val Arg Thr  Glu Ala Gly Ala Ser  Ala Thr Leu 
    1265                 1270                 1275             


Ser Cys  Glu Val Ala Gln Ala  Gln Thr Glu Val Thr  Trp Tyr Lys 
    1280                 1285                 1290             


Asp Gly  Lys Lys Leu Ser Ser  Ser Ser Lys Val Arg  Ile Glu Ala 
    1295                 1300                 1305             


Ala Gly  Cys Met Arg Gln Leu  Val Val Gln Gln Ala  Gly Gln Ala 
    1310                 1315                 1320             


Asp Ala  Gly Glu Tyr Thr Cys  Glu Ala Gly Gly Gln  Arg Leu Ser 
    1325                 1330                 1335             


Phe His  Leu Asp Val Ser Glu  Pro Lys Ala Val Phe  Ala Lys Glu 
    1340                 1345                 1350             


Gln Leu  Ala His Arg Lys Val  Gln Ala Glu Ala Gly  Ala Ile Ala 
    1355                 1360                 1365             


Thr Leu  Ser Cys Glu Val Ala  Gln Ala Gln Thr Glu  Val Thr Trp 
    1370                 1375                 1380             


Tyr Lys  Asp Gly Lys Lys Leu  Ser Ser Ser Ser Lys  Val Arg Met 
    1385                 1390                 1395             


Glu Ala  Val Gly Cys Thr Arg  Arg Leu Val Val Gln  Gln Ala Cys 
    1400                 1405                 1410             


Gln Ala  Asp Thr Gly Glu Tyr  Ser Cys Glu Ala Gly  Gly Gln Arg 
    1415                 1420                 1425             


Leu Ser  Phe Ser Leu Asp Val  Ala Glu Pro Lys Val  Val Phe Ala 
    1430                 1435                 1440             


Lys Glu  Gln Pro Val His Arg  Glu Val Gln Ala Gln  Ala Gly Ala 
    1445                 1450                 1455             


Ser Thr  Thr Leu Ser Cys Glu  Val Ala Gln Ala Gln  Thr Glu Val 
    1460                 1465                 1470             


Met Trp  Tyr Lys Asp Gly Lys  Lys Leu Ser Phe Ser  Ser Lys Val 
    1475                 1480                 1485             


Arg Met  Glu Ala Val Gly Cys  Thr Arg Arg Leu Val  Val Gln Gln 
    1490                 1495                 1500             


Ala Gly  Gln Ala Val Ala Gly  Glu Tyr Ser Cys Glu  Ala Gly Ser 
    1505                 1510                 1515             


Gln Arg  Leu Ser Phe His Leu  His Val Ala Glu Pro  Lys Ala Val 
    1520                 1525                 1530             


Phe Ala  Lys Glu Gln Pro Ala  Ser Arg Glu Val Gln  Ala Glu Ala 
    1535                 1540                 1545             


Gly Thr  Ser Ala Thr Leu Ser  Cys Glu Val Ala Gln  Ala Gln Thr 
    1550                 1555                 1560             


Glu Val  Thr Trp Tyr Lys Asp  Gly Lys Lys Leu Ser  Ser Ser Ser 
    1565                 1570                 1575             


Lys Val  Arg Met Glu Ala Val  Gly Cys Thr Arg Arg  Leu Val Val 
    1580                 1585                 1590             


Gln Glu  Ala Gly Gln Ala Asp  Ala Gly Glu Tyr Ser  Cys Lys Ala 
    1595                 1600                 1605             


Gly Asp  Gln Arg Leu Ser Phe  His Leu His Val Ala  Glu Pro Lys 
    1610                 1615                 1620             


Val Val  Phe Ala Lys Glu Gln  Pro Ala His Arg Glu  Val Gln Ala 
    1625                 1630                 1635             


Glu Ala  Gly Ala Ser Ala Thr  Leu Ser Cys Glu Val  Ala Gln Ala 
    1640                 1645                 1650             


Gln Thr  Glu Val Thr Trp Tyr  Lys Asp Gly Lys Lys  Leu Ser Ser 
    1655                 1660                 1665             


Ser Ser  Lys Val Arg Val Glu  Ala Val Gly Cys Thr  Arg Arg Leu 
    1670                 1675                 1680             


Val Val  Gln Gln Ala Gly Gln  Ala Glu Ala Gly Glu  Tyr Ser Cys 
    1685                 1690                 1695             


Glu Ala  Gly Gly Gln Gln Leu  Ser Phe Arg Leu Gln  Val Ala Glu 
    1700                 1705                 1710             


Leu Glu  Pro Gln Ile Ser Glu  Arg Pro Cys Arg Arg  Glu Pro Leu 
    1715                 1720                 1725             


Val Val  Lys Glu His Glu Asp  Ile Ile Leu Thr Ala  Thr Leu Ala 
    1730                 1735                 1740             


Thr Pro  Ser Ala Ala Thr Val  Thr Trp Leu Lys Asp  Gly Val Glu 
    1745                 1750                 1755             


Ile Arg  Arg Ser Lys Arg His  Glu Thr Ala Ser Gln  Gly Asp Thr 
    1760                 1765                 1770             


His Thr  Leu Thr Val His Gly  Ala Gln Val Leu Asp  Ser Ala Ile 
    1775                 1780                 1785             


Tyr Ser  Cys Arg Val Gly Ala  Glu Gly Gln Asp Phe  Pro Val Gln 
    1790                 1795                 1800             


Val Glu  Glu Val Ala Ala Lys  Phe Cys Arg Leu Leu  Glu Pro Val 
    1805                 1810                 1815             


Cys Gly  Glu Leu Gly Gly Thr  Val Thr Leu Ala Cys  Glu Leu Ser 
    1820                 1825                 1830             


Pro Ala  Cys Ala Glu Val Val  Trp Arg Cys Gly Asn  Thr Gln Leu 
    1835                 1840                 1845             


Arg Val  Gly Lys Arg Phe Gln  Met Val Ala Glu Gly  Pro Val Arg 
    1850                 1855                 1860             


Ser Leu  Thr Val Leu Gly Leu  Arg Ala Glu Asp Ala  Gly Glu Tyr 
    1865                 1870                 1875             


Val Cys  Glu Ser Arg Asp Asp  His Thr Ser Ala Gln  Leu Thr Val 
    1880                 1885                 1890             


Ser Val  Pro Arg Val Val Lys  Phe Met Ser Gly Leu  Ser Thr Val 
    1895                 1900                 1905             


Val Ala  Glu Glu Gly Gly Glu  Ala Thr Phe Gln Cys  Val Val Ser 
    1910                 1915                 1920             


Pro Ser  Asp Val Ala Val Val  Trp Phe Arg Asp Gly  Ala Leu Leu 
    1925                 1930                 1935             


Gln Pro  Ser Glu Lys Phe Ala  Ile Ser Gln Ser Gly  Ala Ser His 
    1940                 1945                 1950             


Ser Leu  Thr Ile Ser Asp Leu  Val Leu Glu Asp Ala  Gly Gln Ile 
    1955                 1960                 1965             


Thr Val  Glu Ala Glu Gly Ala  Ser Ser Ser Ala Ala  Leu Arg Val 
    1970                 1975                 1980             


Arg Glu  Ala Pro Val Leu Phe  Lys Lys Lys Leu Glu  Pro Gln Thr 
    1985                 1990                 1995             


Val Glu  Glu Arg Ser Ser Val  Thr Leu Glu Val Glu  Leu Thr Arg 
    2000                 2005                 2010             


Pro Trp  Pro Glu Leu Arg Trp  Thr Arg Asn Ala Thr  Ala Leu Ala 
    2015                 2020                 2025             


Pro Gly  Lys Asn Val Glu Ile  His Ala Glu Gly Ala  Arg His Arg 
    2030                 2035                 2040             


Leu Val  Leu His Asn Val Gly  Phe Ala Asp Arg Gly  Phe Phe Gly 
    2045                 2050                 2055             


Cys Glu  Thr Pro Asp Asp Lys  Thr Gln Ala Lys Leu  Thr Val Glu 
    2060                 2065                 2070             


Met Arg  Gln Val Arg Leu Val  Arg Gly Leu Gln Ala  Val Glu Ala 
    2075                 2080                 2085             


Arg Glu  Gln Gly Thr Ala Thr  Met Glu Val Gln Leu  Ser His Ala 
    2090                 2095                 2100             


Asp Val  Asp Gly Ser Trp Thr  Arg Asp Gly Leu Arg  Phe Gln Gln 
    2105                 2110                 2115             


Gly Pro  Thr Cys His Leu Ala  Val Arg Gly Pro Met  His Thr Leu 
    2120                 2125                 2130             


Thr Leu  Ser Gly Leu Arg Pro  Glu Asp Ser Gly Leu  Met Val Phe 
    2135                 2140                 2145             


Lys Ala  Glu Gly Val His Thr  Ser Ala Arg Leu Val  Val Thr Glu 
    2150                 2155                 2160             


Leu Pro  Val Ser Phe Ser Arg  Pro Leu Gln Asp Val  Val Thr Thr 
    2165                 2170                 2175             


Glu Lys  Glu Lys Val Thr Leu  Glu Cys Glu Leu Ser  Arg Pro Asn 
    2180                 2185                 2190             


Val Asp  Val Arg Trp Leu Lys  Asp Gly Val Glu Leu  Arg Ala Gly 
    2195                 2200                 2205             


Lys Thr  Met Ala Ile Ala Ala  Gln Gly Ala Cys Arg  Ser Leu Thr 
    2210                 2215                 2220             


Ile Tyr  Arg Cys Glu Phe Ala  Asp Gln Gly Val Tyr  Val Cys Asp 
    2225                 2230                 2235             


Ala His  Asp Ala Gln Ser Ser  Ala Ser Val Lys Val  Gln Gly Arg 
    2240                 2245                 2250             


Thr Tyr  Thr Leu Ile Tyr Arg  Arg Val Leu Ala Glu  Asp Ala Gly 
    2255                 2260                 2265             


Glu Ile  Gln Phe Val Ala Glu  Asn Ala Glu Ser Arg  Ala Gln Leu 
    2270                 2275                 2280             


Arg Val  Lys Glu Leu Pro Val  Thr Leu Val Arg Pro  Leu Arg Asp 
    2285                 2290                 2295             


Lys Ile  Ala Met Glu Lys His  Arg Gly Val Leu Glu  Cys Gln Val 
    2300                 2305                 2310             


Ser Arg  Ala Ser Ala Gln Val  Arg Trp Phe Lys Gly  Ser Gln Glu 
    2315                 2320                 2325             


Leu Gln  Pro Gly Pro Lys Tyr  Glu Leu Val Ser Asp  Gly Leu Tyr 
    2330                 2335                 2340             


Arg Lys  Leu Ile Ile Ser Asp  Val His Ala Glu Asp  Glu Asp Thr 
    2345                 2350                 2355             


Tyr Thr  Cys Asp Ala Gly Asp  Val Lys Thr Ser Ala  Gln Phe Phe 
    2360                 2365                 2370             


Val Glu  Glu Gln Ser Ile Thr  Ile Val Arg Gly Leu  Gln Asp Val 
    2375                 2380                 2385             


Thr Val  Met Glu Pro Ala Pro  Ala Trp Phe Glu Cys  Glu Thr Ser 
    2390                 2395                 2400             


Ile Pro  Ser Val Arg Pro Pro  Lys Trp Leu Leu Gly  Lys Thr Val 
    2405                 2410                 2415             


Leu Gln  Ala Gly Gly Asn Val  Gly Leu Glu Gln Glu  Gly Thr Val 
    2420                 2425                 2430             


His Arg  Leu Met Leu Arg Arg  Thr Cys Ser Thr Met  Thr Gly Pro 
    2435                 2440                 2445             


Val His  Phe Thr Val Gly Lys  Ser Arg Ser Ser Ala  Arg Leu Val 
    2450                 2455                 2460             


Val Ser  Asp Ile Pro Val Val  Leu Thr Arg Pro Leu  Glu Pro Lys 
    2465                 2470                 2475             


Thr Gly  Arg Glu Leu Gln Ser  Val Val Leu Ser Cys  Asp Phe Arg 
    2480                 2485                 2490             


Pro Ala  Pro Lys Ala Val Gln  Trp Tyr Lys Asp Asp  Thr Pro Leu 
    2495                 2500                 2505             


Ser Pro  Ser Glu Lys Phe Lys  Met Ser Leu Glu Gly  Gln Met Ala 
    2510                 2515                 2520             


Glu Leu  Arg Ile Leu Arg Leu  Met Pro Ala Asp Ala  Gly Val Tyr 
    2525                 2530                 2535             


Arg Cys  Gln Ala Gly Ser Ala  His Ser Ser Thr Glu  Val Thr Val 
    2540                 2545                 2550             


Glu Ala  Arg Glu Val Thr Val  Thr Gly Pro Leu Gln  Asp Ala Glu 
    2555                 2560                 2565             


Ala Thr  Glu Glu Gly Trp Ala  Ser Phe Ser Cys Glu  Leu Ser His 
    2570                 2575                 2580             


Glu Asp  Glu Glu Val Glu Trp  Ser Leu Asn Gly Met  Pro Leu Tyr 
    2585                 2590                 2595             


Asn Asp  Ser Phe His Glu Ile  Ser His Lys Gly Arg  Arg His Thr 
    2600                 2605                 2610             


Leu Val  Leu Lys Ser Ile Gln  Arg Ala Asp Ala Gly  Ile Val Arg 
    2615                 2620                 2625             


Ala Ser  Ser Leu Lys Val Ser  Thr Ser Ala Arg Leu  Glu Val Arg 
    2630                 2635                 2640             


Val Lys  Pro Val Val Phe Leu  Lys Ala Leu Asp Asp  Leu Ser Ala 
    2645                 2650                 2655             


Glu Glu  Arg Gly Thr Leu Ala  Leu Gln Cys Glu Val  Ser Asp Pro 
    2660                 2665                 2670             


Glu Ala  His Val Val Trp Arg  Lys Asp Gly Val Gln  Leu Gly Pro 
    2675                 2680                 2685             


Ser Asp  Lys Tyr Asp Phe Leu  His Thr Ala Gly Thr  Arg Gly Leu 
    2690                 2695                 2700             


Val Val  His Asp Val Ser Pro  Glu Asp Ala Gly Leu  Tyr Thr Cys 
    2705                 2710                 2715             


His Val  Gly Ser Glu Glu Thr  Arg Ala Arg Val Arg  Val His Asp 
    2720                 2725                 2730             


Leu His  Val Gly Ile Thr Lys  Arg Leu Lys Thr Met  Glu Val Leu 
    2735                 2740                 2745             


Glu Gly  Glu Ser Cys Ser Phe  Glu Cys Val Leu Ser  His Glu Ser 
    2750                 2755                 2760             


Ala Ser  Asp Pro Ala Met Trp  Thr Val Gly Gly Lys  Thr Val Gly 
    2765                 2770                 2775             


Ser Ser  Ser Arg Phe Gln Ala  Thr Arg Gln Gly Arg  Lys Tyr Ile 
    2780                 2785                 2790             


Leu Val  Val Arg Glu Ala Ala  Pro Ser Asp Ala Gly  Glu Val Val 
    2795                 2800                 2805             


Phe Ser  Val Arg Gly Leu Thr  Ser Lys Ala Ser Leu  Ile Val Arg 
    2810                 2815                 2820             


Glu Arg  Pro Ala Ala Ile Ile  Lys Pro Leu Glu Asp  Gln Trp Val 
    2825                 2830                 2835             


Ala Pro  Gly Glu Asp Val Glu  Leu Arg Cys Glu Leu  Ser Arg Ala 
    2840                 2845                 2850             


Gly Thr  Pro Val His Trp Leu  Lys Asp Arg Lys Ala  Ile Arg Lys 
    2855                 2860                 2865             


Ser Gln  Lys Tyr Asp Val Val  Cys Glu Gly Thr Met  Ala Met Leu 
    2870                 2875                 2880             


Val Ile  Arg Gly Ala Ser Leu  Lys Asp Ala Gly Glu  Tyr Thr Cys 
    2885                 2890                 2895             


Glu Val  Glu Ala Ser Lys Ser  Thr Ala Ser Leu His  Val Glu Glu 
    2900                 2905                 2910             


Lys Ala  Asn Cys Phe Thr Glu  Glu Leu Thr Asn Leu  Gln Val Glu 
    2915                 2920                 2925             


Glu Lys  Gly Thr Ala Val Phe  Thr Cys Lys Thr Glu  His Pro Ala 
    2930                 2935                 2940             


Ala Thr  Val Thr Trp Arg Lys  Gly Leu Leu Glu Leu  Arg Ala Ser 
    2945                 2950                 2955             


Gly Lys  His Gln Pro Ser Gln  Glu Gly Leu Thr Leu  Arg Leu Thr 
    2960                 2965                 2970             


Ile Ser  Ala Leu Glu Lys Ala  Asp Ser Asp Thr Tyr  Thr Cys Asp 
    2975                 2980                 2985             


Ile Gly  Gln Ala Gln Ser Arg  Ala Gln Leu Leu Val  Gln Gly Arg 
    2990                 2995                 3000             


Arg Val  His Ile Ile Glu Asp  Leu Glu Asp Val Asp  Val Gln Glu 
    3005                 3010                 3015             


Gly Ser  Ser Ala Thr Phe Arg  Cys Arg Ile Ser Pro  Ala Asn Tyr 
    3020                 3025                 3030             


Glu Pro  Val His Trp Phe Leu  Asp Lys Thr Pro Leu  His Ala Asn 
    3035                 3040                 3045             


Glu Leu  Asn Glu Ile Asp Ala  Gln Pro Gly Gly Tyr  His Val Leu 
    3050                 3055                 3060             


Thr Leu  Arg Gln Leu Ala Leu  Lys Asp Ser Gly Thr  Ile Tyr Phe 
    3065                 3070                 3075             


Glu Ala  Gly Asp Gln Arg Ala  Ser Ala Ala Leu Arg  Val Thr Glu 
    3080                 3085                 3090             


Lys Pro  Ser Val Phe Ser Arg  Glu Leu Thr Asp Ala  Thr Ile Thr 
    3095                 3100                 3105             


Glu Gly  Glu Asp Leu Thr Leu  Val Cys Glu Thr Ser  Thr Cys Asp 
    3110                 3115                 3120             


Ile Pro  Val Cys Trp Thr Lys  Asp Gly Lys Thr Leu  Arg Gly Ser 
    3125                 3130                 3135             


Ala Arg  Cys Gln Leu Ser His  Glu Gly His Arg Ala  Gln Leu Leu 
    3140                 3145                 3150             


Ile Thr  Gly Ala Thr Leu Gln  Asp Ser Gly Arg Tyr  Lys Cys Glu 
    3155                 3160                 3165             


Ala Gly  Gly Ala Cys Ser Ser  Ser Ile Val Arg Val  His Ala Arg 
    3170                 3175                 3180             


Pro Val  Arg Phe Gln Glu Ala  Leu Lys Asp Leu Glu  Val Leu Glu 
    3185                 3190                 3195             


Gly Gly  Ala Ala Thr Leu Arg  Cys Val Leu Ser Ser  Val Ala Ala 
    3200                 3205                 3210             


Pro Val  Lys Trp Cys Tyr Gly  Asn Asn Val Leu Arg  Pro Gly Asp 
    3215                 3220                 3225             


Lys Tyr  Ser Leu Arg Gln Glu  Gly Ala Met Leu Glu  Leu Val Val 
    3230                 3235                 3240             


Arg Asn  Leu Arg Pro Gln Asp  Ser Gly Arg Tyr Ser  Cys Ser Phe 
    3245                 3250                 3255             


Gly Asp  Gln Thr Thr Ser Ala  Thr Leu Thr Val Thr  Ala Leu Pro 
    3260                 3265                 3270             


Ala Gln  Phe Ile Gly Lys Leu  Arg Asn Lys Glu Ala  Thr Glu Gly 
    3275                 3280                 3285             


Ala Thr  Ala Thr Leu Arg Cys  Glu Leu Ser Lys Ala  Ala Pro Val 
    3290                 3295                 3300             


Glu Trp  Arg Lys Gly Ser Glu  Thr Leu Arg Asp Gly  Asp Arg Tyr 
    3305                 3310                 3315             


Cys Leu  Arg Gln Asp Gly Ala  Met Cys Glu Leu Gln  Ile Arg Gly 
    3320                 3325                 3330             


Leu Ala  Met Val Asp Ala Ala  Glu Tyr Ser Cys Val  Cys Gly Glu 
    3335                 3340                 3345             


Glu Arg  Thr Ser Ala Ser Leu  Thr Ile Arg Pro Met  Pro Ala His 
    3350                 3355                 3360             


Phe Ile  Gly Arg Leu Arg His  Gln Glu Ser Ile Glu  Gly Ala Thr 
    3365                 3370                 3375             


Ala Thr  Leu Arg Cys Glu Leu  Ser Lys Ala Ala Pro  Val Glu Trp 
    3380                 3385                 3390             


Arg Lys  Gly Arg Glu Ser Leu  Arg Asp Gly Asp Arg  His Ser Leu 
    3395                 3400                 3405             


Arg Gln  Asp Gly Ala Val Cys  Glu Leu Gln Ile Cys  Gly Leu Ala 
    3410                 3415                 3420             


Val Ala  Asp Ala Gly Glu Tyr  Ser Cys Val Cys Gly  Glu Glu Arg 
    3425                 3430                 3435             


Thr Ser  Ala Thr Leu Thr Val  Lys Ala Leu Pro Ala  Lys Phe Thr 
    3440                 3445                 3450             


Glu Gly  Leu Arg Asn Glu Glu  Ala Val Glu Gly Ala  Thr Ala Met 
    3455                 3460                 3465             


Leu Trp  Cys Glu Leu Ser Lys  Val Ala Pro Val Glu  Trp Arg Lys 
    3470                 3475                 3480             


Gly Pro  Glu Asn Leu Arg Asp  Gly Asp Arg Tyr Ile  Leu Arg Gln 
    3485                 3490                 3495             


Glu Gly  Thr Arg Cys Glu Leu  Gln Ile Cys Gly Leu  Ala Met Ala 
    3500                 3505                 3510             


Asp Ala  Gly Glu Tyr Leu Cys  Val Cys Gly Gln Glu  Arg Thr Ser 
    3515                 3520                 3525             


Ala Thr  Leu Thr Ile Arg Ala  Leu Pro Ala Arg Phe  Ile Glu Asp 
    3530                 3535                 3540             


Val Lys  Asn Gln Glu Ala Arg  Glu Gly Ala Thr Ala  Val Leu Gln 
    3545                 3550                 3555             


Cys Glu  Leu Asn Ser Ala Ala  Pro Val Glu Trp Arg  Lys Gly Ser 
    3560                 3565                 3570             


Glu Thr  Leu Arg Asp Gly Asp  Arg Tyr Ser Leu Arg  Gln Asp Gly 
    3575                 3580                 3585             


Thr Lys  Cys Glu Leu Gln Ile  Arg Gly Leu Ala Met  Ala Asp Thr 
    3590                 3595                 3600             


Gly Glu  Tyr Ser Cys Val Cys  Gly Gln Glu Arg Thr  Ser Ala Met 
    3605                 3610                 3615             


Leu Thr  Val Arg Ala Leu Pro  Ile Lys Phe Thr Glu  Gly Leu Arg 
    3620                 3625                 3630             


Asn Glu  Glu Ala Thr Glu Gly  Ala Thr Ala Val Leu  Arg Cys Glu 
    3635                 3640                 3645             


Leu Ser  Lys Met Ala Pro Val  Glu Trp Trp Lys Gly  His Glu Thr 
    3650                 3655                 3660             


Leu Arg  Asp Gly Asp Arg His  Ser Leu Arg Gln Asp  Gly Ala Arg 
    3665                 3670                 3675             


Cys Glu  Leu Gln Ile Arg Gly  Leu Val Ala Glu Asp  Ala Gly Glu 
    3680                 3685                 3690             


Tyr Leu  Cys Met Cys Gly Lys  Glu Arg Thr Ser Ala  Met Leu Thr 
    3695                 3700                 3705             


Val Arg  Ala Met Pro Ser Lys  Phe Ile Glu Gly Leu  Arg Asn Glu 
    3710                 3715                 3720             


Glu Ala  Thr Glu Gly Asp Thr  Ala Thr Leu Trp Cys  Glu Leu Ser 
    3725                 3730                 3735             


Lys Ala  Ala Pro Val Glu Trp  Arg Lys Gly His Glu  Thr Leu Arg 
    3740                 3745                 3750             


Asp Gly  Asp Arg His Ser Leu  Arg Gln Asp Gly Ser  Arg Cys Glu 
    3755                 3760                 3765             


Leu Gln  Ile Arg Gly Leu Ala  Val Val Asp Ala Gly  Glu Tyr Ser 
    3770                 3775                 3780             


Cys Val  Cys Gly Gln Glu Arg  Thr Ser Ala Thr Leu  Thr Val Arg 
    3785                 3790                 3795             


Ala Leu  Pro Ala Arg Phe Ile  Glu Asp Val Lys Asn  Gln Glu Ala 
    3800                 3805                 3810             


Arg Glu  Gly Ala Thr Ala Val  Leu Gln Cys Glu Leu  Ser Lys Ala 
    3815                 3820                 3825             


Ala Pro  Val Glu Trp Arg Lys  Gly Ser Glu Thr Leu  Arg Gly Gly 
    3830                 3835                 3840             


Asp Arg  Tyr Ser Leu Arg Gln  Asp Gly Thr Arg Cys  Glu Leu Gln 
    3845                 3850                 3855             


Ile His  Gly Leu Ser Val Ala  Asp Thr Gly Glu Tyr  Ser Cys Val 
    3860                 3865                 3870             


Cys Gly  Gln Glu Arg Thr Ser  Ala Thr Leu Thr Val  Arg Ala Pro 
    3875                 3880                 3885             


Gln Pro  Val Phe Arg Glu Pro  Leu Gln Ser Leu Gln  Ala Glu Glu 
    3890                 3895                 3900             


Gly Ser  Thr Ala Thr Leu Gln  Cys Glu Leu Ser Glu  Pro Thr Ala 
    3905                 3910                 3915             


Thr Val  Val Trp Ser Lys Gly  Gly Leu Gln Leu Gln  Ala Asn Gly 
    3920                 3925                 3930             


Arg Arg  Glu Pro Arg Leu Gln  Gly Cys Thr Ala Glu  Leu Val Leu 
    3935                 3940                 3945             


Gln Asp  Leu Gln Arg Glu Asp  Thr Gly Glu Tyr Thr  Cys Thr Cys 
    3950                 3955                 3960             


Gly Ser  Gln Ala Thr Ser Ala  Thr Leu Thr Val Thr  Ala Ala Pro 
    3965                 3970                 3975             


Val Arg  Phe Leu Arg Glu Leu  Gln His Gln Glu Val  Asp Glu Gly 
    3980                 3985                 3990             


Gly Thr  Ala His Leu Cys Cys  Glu Leu Ser Arg Ala  Gly Ala Ser 
    3995                 4000                 4005             


Val Glu  Trp Arg Lys Gly Ser  Leu Gln Leu Phe Pro  Cys Ala Lys 
    4010                 4015                 4020             


Tyr Gln  Met Val Gln Asp Gly  Ala Ala Ala Glu Leu  Leu Val Arg 
    4025                 4030                 4035             


Gly Val  Glu Gln Glu Asp Ala  Gly Asp Tyr Thr Cys  Asp Thr Gly 
    4040                 4045                 4050             


His Thr  Gln Ser Met Ala Ser  Leu Ser Val Arg Val  Pro Arg Pro 
    4055                 4060                 4065             


Lys Phe  Lys Thr Arg Leu Gln  Ser Leu Glu Gln Glu  Thr Gly Asp 
    4070                 4075                 4080             


Ile Ala  Arg Leu Cys Cys Gln  Leu Ser Asp Ala Glu  Ser Gly Ala 
    4085                 4090                 4095             


Val Val  Gln Trp Leu Lys Glu  Gly Val Glu Leu His  Ala Gly Pro 
    4100                 4105                 4110             


Lys Tyr  Glu Met Arg Ser Gln  Gly Ala Thr Arg Glu  Leu Leu Ile 
    4115                 4120                 4125             


His Gln  Leu Glu Ala Lys Asp  Thr Gly Glu Tyr Ala  Cys Val Thr 
    4130                 4135                 4140             


Gly Gly  Gln Lys Thr Ala Ala  Ser Leu Arg Val Thr  Glu Pro Glu 
    4145                 4150                 4155             


Val Thr  Ile Val Arg Gly Leu  Val Asp Ala Glu Val  Thr Ala Asp 
    4160                 4165                 4170             


Glu Asp  Val Glu Phe Ser Cys  Glu Val Ser Arg Ala  Gly Ala Thr 
    4175                 4180                 4185             


Gly Val  Gln Trp Cys Leu Gln  Gly Leu Pro Leu Gln  Ser Asn Glu 
    4190                 4195                 4200             


Val Thr  Glu Val Ala Val Arg  Asp Gly Arg Ile His  Thr Leu Arg 
    4205                 4210                 4215             


Leu Lys  Gly Val Thr Pro Glu  Asp Ala Gly Thr Val  Ser Phe His 
    4220                 4225                 4230             


Leu Gly  Asn His Ala Ser Ser  Ala Gln Leu Thr Val  Arg Ala Pro 
    4235                 4240                 4245             


Glu Val  Thr Ile Leu Glu Pro  Leu Gln Asp Val Gln  Leu Ser Glu 
    4250                 4255                 4260             


Gly Gln  Asp Ala Ser Phe Gln  Cys Arg Leu Ser Arg  Ala Ser Gly 
    4265                 4270                 4275             


Gln Glu  Ala Arg Trp Ala Leu  Gly Gly Val Pro Leu  Gln Ala Asn 
    4280                 4285                 4290             


Glu Met  Asn Asp Ile Thr Val  Glu Gln Gly Thr Leu  His Leu Leu 
    4295                 4300                 4305             


Thr Leu  His Lys Val Thr Leu  Glu Asp Ala Gly Thr  Val Ser Phe 
    4310                 4315                 4320             


His Val  Gly Thr Cys Ser Ser  Glu Ala Gln Leu Lys  Val Thr Ala 
    4325                 4330                 4335             


Lys Asn  Thr Val Val Arg Gly  Leu Glu Asn Val Glu  Ala Leu Glu 
    4340                 4345                 4350             


Gly Gly  Glu Ala Leu Phe Glu  Cys Gln Leu Ser Gln  Pro Glu Val 
    4355                 4360                 4365             


Ala Ala  His Thr Trp Leu Leu  Asp Asp Glu Pro Val  His Thr Ser 
    4370                 4375                 4380             


Glu Asn  Ala Glu Val Val Phe  Phe Glu Asn Gly Leu  Arg His Leu 
    4385                 4390                 4395             


Leu Leu  Leu Lys Asn Leu Arg  Pro Gln Asp Ser Cys  Arg Val Thr 
    4400                 4405                 4410             


Phe Leu  Ala Gly Asp Met Val  Thr Ser Ala Phe Leu  Thr Val Arg 
    4415                 4420                 4425             


Gly Trp  Arg Leu Glu Ile Leu  Glu Pro Leu Lys Asn  Ala Ala Val 
    4430                 4435                 4440             


Arg Ala  Gly Ala Gln Ala Cys  Phe Thr Cys Thr Leu  Ser Glu Ala 
    4445                 4450                 4455             


Val Pro  Val Gly Glu Ala Ser  Trp Tyr Ile Asn Gly  Ala Ala Val 
    4460                 4465                 4470             


Gln Pro  Asp Asp Ser Asp Trp  Thr Val Thr Ala Asp  Gly Ser His 
    4475                 4480                 4485             


His Ala  Leu Leu Leu Arg Ser  Ala Gln Pro His His  Ala Gly Glu 
    4490                 4495                 4500             


Val Thr  Phe Ala Cys Arg Asp  Ala Val Ala Ser Ala  Arg Leu Thr 
    4505                 4510                 4515             


Val Leu  Gly Leu Pro Asp Pro  Pro Glu Asp Ala Glu  Val Val Ala 
    4520                 4525                 4530             


Arg Ser  Ser His Thr Val Thr  Leu Ser Trp Ala Ala  Pro Met Ser 
    4535                 4540                 4545             


Asp Gly  Gly Gly Gly Leu Cys  Gly Tyr Arg Val Glu  Val Lys Glu 
    4550                 4555                 4560             


Gly Ala  Thr Gly Gln Trp Arg  Leu Cys His Glu Leu  Val Pro Gly 
    4565                 4570                 4575             


Pro Glu  Cys Val Val Asp Gly  Leu Ala Pro Gly Glu  Thr Tyr Arg 
    4580                 4585                 4590             


Phe Arg  Val Ala Ala Val Gly  Pro Val Gly Ala Gly  Glu Pro Val 
    4595                 4600                 4605             


His Leu  Pro Gln Thr Val Arg  Leu Ala Glu Pro Pro  Lys Pro Val 
    4610                 4615                 4620             


Pro Pro  Gln Pro Ser Ala Pro  Glu Ser Arg Gln Val  Ala Ala Gly 
    4625                 4630                 4635             


Glu Asp  Val Ser Leu Glu Leu  Glu Val Val Ala Glu  Ala Gly Glu 
    4640                 4645                 4650             


Val Ile  Trp His Lys Gly Met  Glu Arg Ile Gln Pro  Gly Gly Arg 
    4655                 4660                 4665             


Phe Glu  Val Val Ser Gln Gly  Arg Gln Gln Met Leu  Val Ile Lys 
    4670                 4675                 4680             


Gly Phe  Thr Ala Glu Asp Gln  Gly Glu Tyr His Cys  Gly Leu Ala 
    4685                 4690                 4695             


Gln Gly  Ser Ile Cys Pro Ala  Ala Ala Thr Phe Gln  Val Ala Leu 
    4700                 4705                 4710             


Ser Pro  Ala Ser Val Asp Glu  Ala Pro Gln Pro Ser  Leu Pro Pro 
    4715                 4720                 4725             


Glu Ala  Ala Gln Glu Gly Asp  Leu His Leu Leu Trp  Glu Ala Leu 
    4730                 4735                 4740             


Ala Arg  Lys Arg Arg Met Ser  Arg Glu Pro Thr Leu  Asp Ser Ile 
    4745                 4750                 4755             


Ser Glu  Leu Pro Glu Glu Asp  Gly Arg Ser Gln Arg  Leu Pro Gln 
    4760                 4765                 4770             


Glu Ala  Glu Glu Val Ala Pro  Asp Leu Ser Glu Gly  Tyr Ser Thr 
    4775                 4780                 4785             


Ala Asp  Glu Leu Ala Arg Thr  Gly Asp Ala Asp Leu  Ser His Thr 
    4790                 4795                 4800             


Ser Ser  Asp Asp Glu Ser Arg  Ala Gly Thr Pro Ser  Leu Val Thr 
    4805                 4810                 4815             


Tyr Leu  Lys Lys Ala Gly Arg  Pro Gly Thr Ser Pro  Leu Ala Ser 
    4820                 4825                 4830             


Lys Val  Gly Ala Pro Ala Ala  Pro Ser Val Lys Pro  Gln Gln Gln 
    4835                 4840                 4845             


Gln Glu  Pro Leu Ala Ala Val  Arg Pro Pro Leu Gly  Asp Leu Ser 
    4850                 4855                 4860             


Thr Lys  Asp Leu Gly Asp Pro  Ser Met Asp Lys Ala  Ala Val Lys 
    4865                 4870                 4875             


Ile Gln  Ala Ala Phe Lys Gly  Tyr Lys Val Arg Lys  Glu Met Lys 
    4880                 4885                 4890             


Gln Gln  Glu Gly Pro Met Phe  Ser His Thr Phe Gly  Asp Thr Glu 
    4895                 4900                 4905             


Ala Gln  Val Gly Asp Ala Leu  Arg Leu Glu Cys Val  Val Ala Ser 
    4910                 4915                 4920             


Lys Ala  Asp Val Arg Ala Arg  Trp Leu Lys Asp Gly  Val Glu Leu 
    4925                 4930                 4935             


Thr Asp  Gly Arg His His His  Ile Asp Gln Leu Gly  Asp Gly Thr 
    4940                 4945                 4950             


Cys Ser  Leu Leu Ile Thr Gly  Leu Asp Arg Ala Asp  Ala Gly Cys 
    4955                 4960                 4965             


Tyr Thr  Cys Gln Val Ser Asn  Lys Phe Gly Gln Val  Thr His Ser 
    4970                 4975                 4980             


Ala Cys  Val Val Val Ser Gly  Ser Glu Ser Glu Ala  Glu Ser Ser 
    4985                 4990                 4995             


Ser Gly  Gly Glu Leu Asp Asp  Ala Phe Arg Arg Ala  Ala Arg Arg 
    5000                 5005                 5010             


Leu His  Arg Leu Phe Arg Thr  Lys Ser Pro Ala Glu  Val Ser Asp 
    5015                 5020                 5025             


Glu Glu  Leu Phe Leu Ser Ala  Asp Glu Gly Pro Ala  Glu Pro Glu 
    5030                 5035                 5040             


Glu Pro  Ala Asp Trp Gln Thr  Tyr Arg Glu Asp Glu  His Phe Ile 
    5045                 5050                 5055             


Cys Ile  Arg Phe Glu Ala Leu  Thr Glu Ala Arg Gln  Ala Val Thr 
    5060                 5065                 5070             


Arg Phe  Gln Glu Met Phe Ala  Thr Leu Gly Ile Gly  Val Glu Ile 
    5075                 5080                 5085             


Lys Leu  Val Glu Gln Gly Pro  Arg Arg Val Glu Met  Cys Ile Ser 
    5090                 5095                 5100             


Lys Glu  Thr Pro Ala Pro Val  Val Pro Pro Glu Pro  Leu Pro Ser 
    5105                 5110                 5115             


Leu Leu  Thr Ser Asp Ala Ala  Pro Val Phe Leu Thr  Glu Leu Gln 
    5120                 5125                 5130             


Asn Gln  Glu Val Gln Asp Gly  Tyr Pro Val Ser Phe  Asp Cys Val 
    5135                 5140                 5145             


Val Thr  Gly Gln Pro Met Pro  Ser Val Arg Trp Phe  Lys Asp Gly 
    5150                 5155                 5160             


Lys Leu  Leu Glu Glu Asp Asp  His Tyr Met Ile Asn  Glu Asp Gln 
    5165                 5170                 5175             


Gln Gly  Gly His Gln Leu Ile  Ile Thr Ala Val Val  Pro Ala Asp 
    5180                 5185                 5190             


Met Gly  Val Tyr Arg Cys Leu  Ala Glu Asn Ser Met  Gly Val Ser 
    5195                 5200                 5205             


Ser Thr  Lys Ala Glu Leu Arg  Val Asp Leu Thr Ser  Thr Asp Tyr 
    5210                 5215                 5220             


Asp Thr  Ala Ala Asp Ala Thr  Glu Ser Ser Ser Tyr  Phe Ser Ala 
    5225                 5230                 5235             


Gln Gly  Tyr Leu Ser Ser Arg  Glu Gln Glu Gly Thr  Glu Ser Thr 
    5240                 5245                 5250             


Thr Asp  Glu Gly Gln Leu Pro  Gln Val Val Glu Glu  Leu Arg Asp 
    5255                 5260                 5265             


Leu Gln  Val Ala Pro Gly Thr  Arg Leu Ala Lys Phe  Gln Leu Lys 
    5270                 5275                 5280             


Val Lys  Gly Tyr Pro Ala Pro  Arg Leu Tyr Trp Phe  Lys Asp Gly 
    5285                 5290                 5295             


Gln Pro  Leu Thr Ala Ser Ala  His Ile Arg Met Thr  Asp Lys Lys 
    5300                 5305                 5310             


Ile Leu  His Thr Leu Glu Ile  Ile Ser Val Thr Arg  Glu Asp Ser 
    5315                 5320                 5325             


Gly Gln  Tyr Ala Ala Tyr Ile  Ser Asn Ala Met Gly  Ala Ala Tyr 
    5330                 5335                 5340             


Ser Ser  Ala Arg Leu Leu Val  Arg Gly Pro Asp Glu  Pro Glu Glu 
    5345                 5350                 5355             


Lys Pro  Ala Ser Asp Val His  Glu Gln Leu Val Pro  Pro Arg Met 
    5360                 5365                 5370             


Leu Glu  Arg Phe Thr Pro Lys  Lys Val Lys Lys Gly  Ser Ser Ile 
    5375                 5380                 5385             


Thr Phe  Ser Val Lys Val Glu  Gly Arg Pro Val Pro  Thr Val His 
    5390                 5395                 5400             


Trp Leu  Arg Glu Glu Ala Glu  Arg Gly Val Leu Trp  Ile Gly Pro 
    5405                 5410                 5415             


Asp Thr  Pro Gly Tyr Thr Val  Ala Ser Ser Ala Gln  Gln His Ser 
    5420                 5425                 5430             


Leu Val  Leu Leu Asp Val Gly  Arg Gln His Gln Gly  Thr Tyr Thr 
    5435                 5440                 5445             


Cys Ile  Ala Ser Asn Ala Ala  Gly Gln Ala Leu Cys  Ser Ala Ser 
    5450                 5455                 5460             


Leu His  Val Ser Gly Leu Pro  Lys Val Glu Glu Gln  Glu Lys Val 
    5465                 5470                 5475             


Lys Glu  Ala Leu Ile Ser Thr  Phe Leu Gln Gly Thr  Thr Gln Ala 
    5480                 5485                 5490             


Ile Ser  Ala Gln Gly Leu Glu  Thr Ala Ser Phe Ala  Asp Leu Gly 
    5495                 5500                 5505             


Gly Gln  Arg Lys Glu Glu Pro  Leu Ala Ala Lys Glu  Ala Leu Gly 
    5510                 5515                 5520             


His Leu  Ser Leu Ala Glu Val  Gly Thr Glu Glu Phe  Leu Gln Lys 
    5525                 5530                 5535             


Leu Thr  Ser Gln Ile Thr Glu  Met Val Ser Ala Lys  Ile Thr Gln 
    5540                 5545                 5550             


Ala Lys  Leu Gln Val Pro Gly  Gly Asp Ser Asp Glu  Asp Ser Lys 
    5555                 5560                 5565             


Thr Pro  Ser Ala Ser Pro Arg  His Gly Arg Ser Arg  Pro Ser Ser 
    5570                 5575                 5580             


Ser Ile  Gln Glu Ser Ser Ser  Glu Ser Glu Asp Gly  Asp Ala Arg 
    5585                 5590                 5595             


Gly Glu  Ile Phe Asp Ile Tyr  Val Val Thr Ala Asp  Tyr Leu Pro 
    5600                 5605                 5610             


Leu Gly  Ala Glu Gln Asp Ala  Ile Thr Leu Arg Glu  Gly Gln Tyr 
    5615                 5620                 5625             


Val Glu  Val Leu Asp Ala Ala  His Pro Leu Arg Trp  Leu Val Arg 
    5630                 5635                 5640             


Thr Lys  Pro Thr Lys Ser Ser  Pro Ser Arg Gln Gly  Trp Val Ser 
    5645                 5650                 5655             


Pro Ala  Tyr Leu Asp Arg Arg  Leu Lys Leu Ser Pro  Glu Trp Gly 
    5660                 5665                 5670             


Ala Ala  Glu Ala Pro Glu Phe  Pro Gly Glu Ala Val  Ser Glu Asp 
    5675                 5680                 5685             


Glu Tyr  Lys Ala Arg Leu Ser  Ser Val Ile Gln Glu  Leu Leu Ser 
    5690                 5695                 5700             


Ser Glu  Gln Ala Phe Val Glu  Glu Leu Gln Phe Leu  Gln Ser His 
    5705                 5710                 5715             


His Leu  Gln His Leu Glu Arg  Cys Pro His Val Pro  Ile Ala Val 
    5720                 5725                 5730             


Ala Gly  Gln Lys Ala Val Ile  Phe Arg Asn Val Arg  Asp Ile Gly 
    5735                 5740                 5745             


Arg Phe  His Ser Ser Phe Leu  Gln Glu Leu Gln Gln  Cys Asp Thr 
    5750                 5755                 5760             


Asp Asp  Asp Val Ala Met Cys  Phe Ile Lys Asn Gln  Ala Ala Phe 
    5765                 5770                 5775             


Glu Gln  Tyr Leu Glu Phe Leu  Val Gly Arg Val Gln  Ala Glu Ser 
    5780                 5785                 5790             


Val Val  Val Ser Thr Ala Ile  Gln Glu Phe Tyr Lys  Lys Tyr Ala 
    5795                 5800                 5805             


Glu Glu  Ala Leu Leu Ala Gly  Asp Pro Ser Gln Pro  Pro Pro Pro 
    5810                 5815                 5820             


Pro Leu  Gln His Tyr Leu Glu  Gln Pro Val Glu Arg  Val Gln Arg 
    5825                 5830                 5835             


Tyr Gln  Ala Leu Leu Lys Glu  Leu Ile Arg Asn Lys  Ala Arg Asn 
    5840                 5845                 5850             


Arg Gln  Asn Cys Ala Leu Leu  Glu Gln Ala Tyr Ala  Val Val Ser 
    5855                 5860                 5865             


Ala Leu  Pro Gln Arg Ala Glu  Asn Lys Leu His Val  Ser Leu Met 
    5870                 5875                 5880             


Glu Asn  Tyr Pro Gly Thr Leu  Gln Ala Leu Gly Glu  Pro Ile Arg 
    5885                 5890                 5895             


Gln Gly  His Phe Ile Val Trp  Glu Gly Ala Pro Gly  Ala Arg Met 
    5900                 5905                 5910             


Pro Trp  Lys Gly His Asn Arg  His Val Phe Leu Phe  Arg Asn His 
    5915                 5920                 5925             


Leu Val  Ile Cys Lys Pro Arg  Arg Asp Ser Arg Thr  Asp Thr Val 
    5930                 5935                 5940             


Ser Tyr  Val Phe Arg Asn Met  Met Lys Leu Ser Ser  Ile Asp Leu 
    5945                 5950                 5955             


Asn Asp  Gln Val Glu Gly Asp  Asp Arg Ala Phe Glu  Val Trp Gln 
    5960                 5965                 5970             


Glu Arg  Glu Asp Ser Val Arg  Lys Tyr Leu Leu Gln  Ala Arg Thr 
    5975                 5980                 5985             


Ala Ile  Ile Lys Ser Ser Trp  Val Lys Glu Ile Cys  Gly Ile Gln 
    5990                 5995                 6000             


Gln Arg  Leu Ala Leu Pro Val  Trp Arg Pro Pro Asp  Phe Glu Glu 
    6005                 6010                 6015             


Glu Leu  Ala Asp Cys Thr Ala  Glu Leu Gly Glu Thr  Val Lys Leu 
    6020                 6025                 6030             


Ala Cys  Arg Val Thr Gly Thr  Pro Lys Pro Val Ile  Ser Trp Tyr 
    6035                 6040                 6045             


Lys Asp  Gly Lys Ala Val Gln  Val Asp Pro His His  Ile Leu Ile 
    6050                 6055                 6060             


Glu Asp  Pro Asp Gly Ser Cys  Ala Leu Ile Leu Asp  Ser Leu Thr 
    6065                 6070                 6075             


Gly Val  Asp Ser Gly Gln Tyr  Met Cys Phe Ala Ala  Ser Ala Ala 
    6080                 6085                 6090             


Gly Asn  Cys Ser Thr Leu Gly  Lys Ile Leu Val Gln  Val Pro Pro 
    6095                 6100                 6105             


Arg Phe  Val Asn Lys Val Arg  Ala Ser Pro Phe Val  Glu Gly Glu 
    6110                 6115                 6120             


Asp Ala  Gln Phe Thr Cys Thr  Ile Glu Gly Ala Pro  Tyr Pro Gln 
    6125                 6130                 6135             


Ile Arg  Trp Tyr Lys Asp Gly  Ala Leu Leu Thr Thr  Gly Asn Lys 
    6140                 6145                 6150             


Phe Gln  Thr Leu Ser Glu Pro  Arg Ser Gly Leu Leu  Val Leu Val 
    6155                 6160                 6165             


Ile Arg  Ala Ala Ser Lys Glu  Asp Leu Gly Leu Tyr  Glu Cys Glu 
    6170                 6175                 6180             


Leu Val  Asn Arg Leu Gly Ser  Ala Arg Ala Ser Ala  Glu Leu Arg 
    6185                 6190                 6195             


Ile Gln  Ser Pro Met Leu Gln  Ala Gln Glu Gln Cys  His Arg Glu 
    6200                 6205                 6210             


Gln Leu  Val Ala Ala Val Glu  Asp Thr Thr Leu Glu  Arg Ala Asp 
    6215                 6220                 6225             


Gln Glu  Val Thr Ser Val Leu  Lys Arg Leu Leu Gly  Pro Lys Ala 
    6230                 6235                 6240             


Pro Gly  Pro Ser Thr Gly Asp  Leu Thr Gly Pro Gly  Pro Cys Pro 
    6245                 6250                 6255             


Arg Gly  Ala Pro Ala Leu Gln  Glu Thr Gly Ser Gln  Pro Pro Val 
    6260                 6265                 6270             


Thr Gly  Thr Ser Glu Ala Pro  Ala Val Pro Pro Arg  Val Pro Gln 
    6275                 6280                 6285             


Pro Leu  Leu His Glu Gly Pro  Glu Gln Glu Pro Glu  Ala Ile Ala 
    6290                 6295                 6300             


Arg Ala  Gln Glu Trp Thr Val  Pro Ile Arg Met Glu  Gly Ala Ala 
    6305                 6310                 6315             


Trp Pro  Gly Ala Gly Thr Gly  Glu Leu Leu Trp Asp  Val His Ser 
    6320                 6325                 6330             


His Val  Val Arg Glu Thr Thr  Gln Arg Thr Tyr Thr  Tyr Gln Ala 
    6335                 6340                 6345             


Ile Asp  Thr His Thr Ala Arg  Pro Pro Ser Met Gln  Val Thr Ile 
    6350                 6355                 6360             


Glu Asp  Val Gln Ala Gln Thr  Gly Gly Thr Ala Gln  Phe Glu Ala 
    6365                 6370                 6375             


Ile Ile  Glu Gly Asp Pro Gln  Pro Ser Val Thr Trp  Tyr Lys Asp 
    6380                 6385                 6390             


Ser Val  Gln Leu Val Asp Ser  Thr Arg Leu Ser Gln  Gln Gln Glu 
    6395                 6400                 6405             


Gly Thr  Thr Tyr Ser Leu Val  Leu Arg His Val Ala  Ser Lys Asp 
    6410                 6415                 6420             


Ala Gly  Val Tyr Thr Cys Leu  Ala Gln Asn Thr Gly  Gly Gln Val 
    6425                 6430                 6435             


Leu Cys  Lys Ala Glu Leu Leu  Val Leu Gly Gly Asp  Asn Glu Pro 
    6440                 6445                 6450             


Asp Ser  Glu Lys Gln Ser His  Arg Arg Lys Leu His  Ser Phe Tyr 
    6455                 6460                 6465             


Glu Val  Lys Glu Glu Ile Gly  Arg Gly Val Phe Gly  Phe Val Lys 
    6470                 6475                 6480             


Arg Val  Gln His Lys Gly Asn  Lys Ile Leu Cys Ala  Ala Lys Phe 
    6485                 6490                 6495             


Ile Pro  Leu Arg Ser Arg Thr  Arg Ala Gln Ala Tyr  Arg Glu Arg 
    6500                 6505                 6510             


Asp Ile  Leu Ala Ala Leu Ser  His Pro Leu Val Thr  Gly Leu Leu 
    6515                 6520                 6525             


Asp Gln  Phe Glu Thr Arg Lys  Thr Leu Ile Leu Ile  Leu Glu Leu 
    6530                 6535                 6540             


Cys Ser  Ser Glu Glu Leu Leu  Asp Arg Leu Tyr Arg  Lys Gly Val 
    6545                 6550                 6555             


Val Thr  Glu Ala Glu Val Lys  Val Tyr Ile Gln Gln  Leu Val Glu 
    6560                 6565                 6570             


Gly Leu  His Tyr Leu His Ser  His Gly Val Leu His  Leu Asp Ile 
    6575                 6580                 6585             


Lys Pro  Ser Asn Ile Leu Met  Val His Pro Ala Arg  Glu Asp Ile 
    6590                 6595                 6600             


Lys Ile  Cys Asp Phe Gly Phe  Ala Gln Asn Ile Thr  Pro Ala Glu 
    6605                 6610                 6615             


Leu Gln  Phe Ser Gln Tyr Gly  Ser Pro Glu Phe Val  Ser Pro Glu 
    6620                 6625                 6630             


Ile Ile  Gln Gln Asn Pro Val  Ser Glu Ala Ser Asp  Ile Trp Ala 
    6635                 6640                 6645             


Met Gly  Val Ile Ser Tyr Leu  Ser Leu Thr Cys Ser  Ser Pro Phe 
    6650                 6655                 6660             


Ala Gly  Glu Ser Asp Arg Ala  Thr Leu Leu Asn Val  Leu Glu Gly 
    6665                 6670                 6675             


Arg Val  Ser Trp Ser Ser Pro  Met Ala Ala His Leu  Ser Glu Asp 
    6680                 6685                 6690             


Ala Lys  Asp Phe Ile Lys Ala  Thr Leu Gln Arg Ala  Pro Gln Ala 
    6695                 6700                 6705             


Arg Pro  Ser Ala Ala Gln Cys  Leu Ser His Pro Trp  Phe Leu Lys 
    6710                 6715                 6720             


Ser Met  Pro Ala Glu Glu Ala  His Phe Ile Asn Thr  Lys Gln Leu 
    6725                 6730                 6735             


Lys Phe  Leu Leu Ala Arg Ser  Arg Trp Gln Arg Ser  Leu Met Ser 
    6740                 6745                 6750             


Tyr Lys  Ser Ile Leu Val Met  Arg Ser Ile Pro Glu  Leu Leu Arg 
    6755                 6760                 6765             


Gly Pro  Pro Asp Ser Pro Ser  Leu Gly Val Ala Arg  His Leu Cys 
    6770                 6775                 6780             


Arg Asp  Thr Gly Gly Ser Ser  Ser Ser Ser Ser Ser  Ser Asp Asn 
    6785                 6790                 6795             


Glu Leu  Ala Pro Phe Ala Arg  Ala Lys Ser Leu Pro  Pro Ser Pro 
    6800                 6805                 6810             


Val Thr  His Ser Pro Leu Leu  His Pro Arg Gly Phe  Leu Arg Pro 
    6815                 6820                 6825             


Ser Ala  Ser Leu Pro Glu Glu  Ala Glu Ala Ser Glu  Arg Ser Thr 
    6830                 6835                 6840             


Glu Ala  Pro Ala Pro Pro Ala  Ser Pro Glu Gly Ala  Gly Pro Pro 
    6845                 6850                 6855             


Ala Ala  Gln Gly Cys Val Pro  Arg His Ser Val Ile  Arg Ser Leu 
    6860                 6865                 6870             


Phe Tyr  His Gln Ala Gly Glu  Ser Pro Glu His Gly  Ala Leu Ala 
    6875                 6880                 6885             


Pro Gly  Ser Arg Arg His Pro  Ala Arg Arg Arg His  Leu Leu Lys 
    6890                 6895                 6900             


Gly Gly  Tyr Ile Ala Gly Ala  Leu Pro Gly Leu Arg  Glu Pro Leu 
    6905                 6910                 6915             


Met Glu  His Arg Val Leu Glu  Glu Glu Ala Ala Arg  Glu Glu Gln 
    6920                 6925                 6930             


Ala Thr  Leu Leu Ala Lys Ala  Pro Ser Phe Glu Thr  Ala Leu Arg 
    6935                 6940                 6945             


Leu Pro  Ala Ser Gly Thr His  Leu Ala Pro Gly His  Ser His Ser 
    6950                 6955                 6960             


Leu Glu  His Asp Ser Pro Ser  Thr Pro Arg Pro Ser  Ser Glu Ala 
    6965                 6970                 6975             


Cys Gly  Glu Ala Gln Arg Leu  Pro Ser Ala Pro Ser  Gly Gly Ala 
    6980                 6985                 6990             


Pro Ile  Arg Asp Met Gly His  Pro Gln Gly Ser Lys  Gln Leu Pro 
    6995                 7000                 7005             


Ser Thr  Gly Gly His Pro Gly  Thr Ala Gln Pro Glu  Arg Pro Ser 
    7010                 7015                 7020             


Pro Asp  Ser Pro Trp Gly Gln  Pro Ala Pro Phe Cys  His Pro Lys 
    7025                 7030                 7035             


Gln Gly  Ser Ala Pro Gln Glu  Gly Cys Ser Pro His  Pro Ala Val 
    7040                 7045                 7050             


Ala Pro  Cys Pro Pro Gly Ser  Phe Pro Pro Gly Ser  Cys Lys Glu 
    7055                 7060                 7065             


Ala Pro  Leu Val Pro Ser Ser  Pro Phe Leu Gly Gln  Pro Gln Ala 
    7070                 7075                 7080             


Pro Pro  Ala Pro Ala Lys Ala  Ser Pro Pro Leu Asp  Ser Lys Met 
    7085                 7090                 7095             


Gly Pro  Gly Asp Ile Ser Leu  Pro Gly Arg Pro Lys  Pro Gly Pro 
    7100                 7105                 7110             


Cys Ser  Ser Pro Gly Ser Ala  Ser Gln Ala Ser Ser  Ser Gln Val 
    7115                 7120                 7125             


Ser Ser  Leu Arg Val Gly Ser  Ser Gln Val Gly Thr  Glu Pro Gly 
    7130                 7135                 7140             


Pro Ser  Leu Asp Ala Glu Gly  Trp Thr Gln Glu Ala  Glu Asp Leu 
    7145                 7150                 7155             


Ser Asp  Ser Thr Pro Thr Leu  Gln Arg Pro Gln Glu  Gln Ala Thr 
    7160                 7165                 7170             


Met Arg  Lys Phe Ser Leu Gly  Gly Arg Gly Gly Tyr  Ala Gly Val 
    7175                 7180                 7185             


Ala Gly  Tyr Gly Thr Phe Ala  Phe Gly Gly Asp Ala  Gly Gly Met 
    7190                 7195                 7200             


Leu Gly  Gln Gly Pro Met Trp  Ala Arg Ile Ala Trp  Ala Val Ser 
    7205                 7210                 7215             


Gln Ser  Glu Glu Glu Glu Gln  Glu Glu Ala Arg Ala  Glu Ser Gln 
    7220                 7225                 7230             


Ser Glu  Glu Gln Gln Glu Ala  Arg Ala Glu Ser Pro  Leu Pro Gln 
    7235                 7240                 7245             


Val Ser  Ala Arg Pro Val Pro  Glu Val Gly Arg Ala  Pro Thr Arg 
    7250                 7255                 7260             


Ser Ser  Pro Glu Pro Thr Pro  Trp Glu Asp Ile Gly  Gln Val Ser 
    7265                 7270                 7275             


Leu Val  Gln Ile Arg Asp Leu  Ser Gly Asp Ala Glu  Ala Ala Asp 
    7280                 7285                 7290             


Thr Ile  Ser Leu Asp Ile Ser  Glu Val Asp Pro Ala  Tyr Leu Asn 
    7295                 7300                 7305             


Leu Ser  Asp Leu Tyr Asp Ile  Lys Tyr Leu Pro Phe  Glu Phe Met 
    7310                 7315                 7320             


Ile Phe  Arg Lys Val Pro Lys  Ser Ala Gln Pro Glu  Pro Pro Ser 
    7325                 7330                 7335             


Pro Met  Ala Glu Glu Glu Leu  Ala Glu Phe Pro Glu  Pro Thr Trp 
    7340                 7345                 7350             


Pro Trp  Pro Gly Glu Leu Gly  Pro His Ala Gly Leu  Glu Ile Thr 
    7355                 7360                 7365             


Glu Glu  Ser Glu Asp Val Asp  Ala Leu Leu Ala Glu  Ala Ala Val 
    7370                 7375                 7380             


Gly Arg  Lys Arg Lys Trp Ser  Ser Pro Ser Arg Ser  Leu Phe His 
    7385                 7390                 7395             


Phe Pro  Gly Arg His Leu Pro  Leu Asp Glu Pro Ala  Glu Leu Gly 
    7400                 7405                 7410             


Leu Arg  Glu Arg Val Lys Ala  Ser Val Glu His Ile  Ser Arg Ile 
    7415                 7420                 7425             


Leu Lys  Gly Arg Pro Glu Gly  Leu Glu Lys Glu Gly  Pro Pro Arg 
    7430                 7435                 7440             


Lys Lys  Pro Gly Leu Ala Ser  Phe Arg Leu Ser Gly  Leu Lys Ser 
    7445                 7450                 7455             


Trp Asp  Arg Ala Pro Thr Phe  Leu Arg Glu Leu Ser  Asp Glu Thr 
    7460                 7465                 7470             


Val Val  Leu Gly Gln Ser Val  Thr Leu Ala Cys Gln  Val Ser Ala 
    7475                 7480                 7485             


Gln Pro  Ala Ala Gln Ala Thr  Trp Ser Lys Asp Gly  Ala Pro Leu 
    7490                 7495                 7500             


Glu Ser  Ser Ser Arg Val Leu  Ile Ser Ala Thr Leu  Lys Asn Phe 
    7505                 7510                 7515             


Gln Leu  Leu Thr Ile Leu Val  Val Val Ala Glu Asp  Leu Gly Val 
    7520                 7525                 7530             


Tyr Thr  Cys Ser Val Ser Asn  Ala Leu Gly Thr Val  Thr Thr Thr 
    7535                 7540                 7545             


Gly Val  Leu Arg Lys Ala Glu  Arg Pro Ser Ser Ser  Pro Cys Pro 
    7550                 7555                 7560             


Asp Ile  Gly Glu Val Tyr Ala  Asp Gly Val Leu Leu  Val Trp Lys 
    7565                 7570                 7575             


Pro Val  Glu Ser Tyr Gly Pro  Val Thr Tyr Ile Val  Gln Cys Ser 
    7580                 7585                 7590             


Leu Glu  Gly Gly Ser Trp Thr  Thr Leu Ala Ser Asp  Ile Phe Asp 
    7595                 7600                 7605             


Cys Cys  Tyr Leu Thr Ser Lys  Leu Ser Arg Gly Gly  Thr Tyr Thr 
    7610                 7615                 7620             


Phe Arg  Thr Ala Cys Val Ser  Lys Ala Gly Met Gly  Pro Tyr Ser 
    7625                 7630                 7635             


Ser Pro  Ser Glu Gln Val Leu  Leu Gly Gly Pro Ser  His Leu Ala 
    7640                 7645                 7650             


Ser Glu  Glu Glu Ser Gln Gly  Arg Ser Ala Gln Pro  Leu Pro Ser 
    7655                 7660                 7665             


Thr Lys  Thr Phe Ala Phe Gln  Thr Gln Ile Gln Arg  Gly Arg Phe 
    7670                 7675                 7680             


Ser Val  Val Arg Gln Cys Trp  Glu Lys Ala Ser Gly  Arg Ala Leu 
    7685                 7690                 7695             


Ala Ala  Lys Ile Ile Pro Tyr  His Pro Lys Asp Lys  Thr Ala Val 
    7700                 7705                 7710             


Leu Arg  Glu Tyr Glu Ala Leu  Lys Gly Leu Arg His  Pro His Leu 
    7715                 7720                 7725             


Ala Gln  Leu His Ala Ala Tyr  Leu Ser Pro Arg His  Leu Val Leu 
    7730                 7735                 7740             


Ile Leu  Glu Leu Cys Ser Gly  Pro Glu Leu Leu Pro  Cys Leu Ala 
    7745                 7750                 7755             


Glu Arg  Ala Ser Tyr Ser Glu  Ser Glu Val Lys Asp  Tyr Leu Trp 
    7760                 7765                 7770             


Gln Met  Leu Ser Ala Thr Gln  Tyr Leu His Asn Gln  His Ile Leu 
    7775                 7780                 7785             


His Leu  Asp Leu Arg Ser Glu  Asn Met Ile Ile Thr  Glu Tyr Asn 
    7790                 7795                 7800             


Leu Leu  Lys Val Val Asp Leu  Gly Asn Ala Gln Ser  Leu Ser Gln 
    7805                 7810                 7815             


Glu Lys  Val Leu Pro Ser Asp  Lys Phe Lys Asp Tyr  Leu Glu Thr 
    7820                 7825                 7830             


Met Ala  Pro Glu Leu Leu Glu  Gly Gln Gly Ala Val  Pro Gln Thr 
    7835                 7840                 7845             


Asp Ile  Trp Ala Ile Gly Val  Thr Ala Phe Ile Met  Leu Ser Ala 
    7850                 7855                 7860             


Glu Tyr  Pro Val Ser Ser Glu  Gly Ala Arg Asp Leu  Gln Arg Gly 
    7865                 7870                 7875             


Leu Arg  Lys Gly Leu Val Arg  Leu Ser Arg Cys Tyr  Ala Gly Leu 
    7880                 7885                 7890             


Ser Gly  Gly Ala Val Ala Phe  Leu Arg Ser Thr Leu  Cys Ala Gln 
    7895                 7900                 7905             


Pro Trp  Gly Arg Pro Cys Ala  Ser Ser Cys Leu Gln  Cys Pro Trp 
    7910                 7915                 7920             


Leu Thr  Glu Glu Gly Pro Ala  Cys Ser Arg Pro Ala  Pro Val Thr 
    7925                 7930                 7935             


Phe Pro  Thr Ala Arg Leu Arg  Val Phe Val Arg Asn  Arg Glu Lys 
    7940                 7945                 7950             


Arg Arg  Ala Leu Leu Tyr Lys  Arg His Asn Leu Ala  Gln Val Arg 
    7955                 7960                 7965             


<210>  144
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ala Ala Ala Thr Leu Leu Arg Ala Thr Pro His Phe Ser Gly Leu 
1               5                   10                  15      


Ala Ala Gly Arg Thr Phe Leu Leu Gln Gly Leu Leu Arg Leu Leu Lys 
            20                  25                  30          


Ala Pro Ala Leu Pro Leu Leu Cys Arg Gly Leu Ala Val Glu Ala Lys 
        35                  40                  45              


Lys Thr Tyr Val Arg Asp Lys Pro His Val Asn Val Gly Thr Ile Gly 
    50                  55                  60                  


His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile Thr Lys Ile 
65                  70                  75                  80  


Leu Ala Glu Gly Gly Gly Ala Lys Phe Lys Lys Tyr Glu Glu Ile Asp 
                85                  90                  95      


Asn Ala Pro Glu Glu Arg Ala Arg Gly Ile Thr Ile Asn Ala Ala His 
            100                 105                 110         


Val Glu Tyr Ser Thr Ala Ala Arg His Tyr Ala His Thr Asp Cys Pro 
        115                 120                 125             


Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Thr Ala Pro Leu 
    130                 135                 140                 


Asp Gly Cys Ile Leu Val Val Ala Ala Asn Asp Gly Pro Met Pro Gln 
145                 150                 155                 160 


Thr Arg Glu His Leu Leu Leu Ala Arg Gln Ile Gly Val Glu His Val 
                165                 170                 175     


Val Val Tyr Val Asn Lys Ala Asp Ala Val Gln Asp Ser Glu Met Val 
            180                 185                 190         


Glu Leu Val Glu Leu Glu Ile Arg Glu Leu Leu Thr Glu Phe Gly Tyr 
        195                 200                 205             


Lys Gly Glu Glu Thr Pro Val Ile Val Gly Ser Ala Leu Cys Ala Leu 
    210                 215                 220                 


Glu Gly Arg Asp Pro Glu Leu Gly Leu Lys Ser Val Gln Lys Leu Leu 
225                 230                 235                 240 


Asp Ala Val Asp Thr Tyr Ile Pro Val Pro Ala Arg Asp Leu Glu Lys 
                245                 250                 255     


Pro Phe Leu Leu Pro Val Glu Ala Val Tyr Ser Val Pro Gly Arg Gly 
            260                 265                 270         


Thr Val Val Thr Gly Thr Leu Glu Arg Gly Ile Leu Lys Lys Gly Asp 
        275                 280                 285             


Glu Cys Glu Leu Leu Gly His Ser Lys Asn Ile Arg Thr Val Val Thr 
    290                 295                 300                 


Gly Ile Glu Met Phe His Lys Ser Leu Glu Arg Ala Glu Ala Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Ala Leu Val Arg Gly Leu Lys Arg Glu Asp Leu Arg Arg 
                325                 330                 335     


Gly Leu Val Met Val Lys Pro Gly Ser Ile Lys Pro His Gln Lys Val 
            340                 345                 350         


Glu Ala Gln Val Tyr Ile Leu Ser Lys Glu Glu Gly Gly Arg His Lys 
        355                 360                 365             


Pro Phe Val Ser His Phe Met Pro Val Met Phe Ser Leu Thr Trp Asp 
    370                 375                 380                 


Met Ala Cys Arg Ile Ile Leu Pro Pro Glu Lys Glu Leu Ala Met Pro 
385                 390                 395                 400 


Gly Glu Asp Leu Lys Phe Asn Leu Ile Leu Arg Gln Pro Met Ile Leu 
                405                 410                 415     


Glu Lys Gly Gln Arg Phe Thr Leu Arg Asp Gly Asn Arg Thr Ile Gly 
            420                 425                 430         


Thr Gly Leu Val Thr Asn Thr Leu Ala Met Thr Glu Glu Glu Lys Asn 
        435                 440                 445             


Ile Lys Trp Gly 
    450         


<210>  145
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210>  146
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Asp Trp Ser Phe Phe Arg Val Val Ala Met Leu Phe Ile Phe Leu 
1               5                   10                  15      


Val Val Val Glu Val Asn Ser Glu Phe Arg Ile Gln Val Arg Asp Tyr 
            20                  25                  30          


Asn Thr Lys Asn Gly Thr Ile Lys Trp His Ser Ile Arg Arg Gln Lys 
        35                  40                  45              


Arg Glu Trp Ile Lys Phe Ala Ala Ala Cys Arg Glu Gly Glu Asp Asn 
    50                  55                  60                  


Ser Lys Arg Asn Pro Ile Ala Lys Ile His Ser Asp Cys Ala Ala Asn 
65                  70                  75                  80  


Gln Gln Val Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Gln Pro Pro 
                85                  90                  95      


Tyr Gly Ile Phe Val Ile Asn Gln Lys Thr Gly Glu Ile Asn Ile Thr 
            100                 105                 110         


Ser Ile Val Asp Arg Glu Val Thr Pro Phe Phe Ile Ile Tyr Cys Arg 
        115                 120                 125             


Ala Leu Asn Ser Met Gly Gln Asp Leu Glu Arg Pro Leu Glu Leu Arg 
    130                 135                 140                 


Val Arg Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe Ser Met Ala 
145                 150                 155                 160 


Thr Phe Ala Gly Gln Ile Glu Glu Asn Ser Asn Ala Asn Thr Leu Val 
                165                 170                 175     


Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn Asn Leu Asn Ser 
            180                 185                 190         


Lys Ile Ala Phe Lys Ile Ile Arg Gln Glu Pro Ser Asp Ser Pro Met 
        195                 200                 205             


Phe Ile Ile Asn Arg Asn Thr Gly Glu Ile Arg Thr Met Asn Asn Phe 
    210                 215                 220                 


Leu Asp Arg Glu Gln Tyr Gly Gln Tyr Ala Leu Ala Val Arg Gly Ser 
225                 230                 235                 240 


Asp Arg Asp Gly Gly Ala Asp Gly Met Ser Ala Glu Cys Glu Cys Asn 
                245                 250                 255     


Ile Lys Ile Leu Asp Val Asn Asp Asn Ile Pro Tyr Met Glu Gln Ser 
            260                 265                 270         


Ser Tyr Thr Ile Glu Ile Gln Glu Asn Thr Leu Asn Ser Asn Leu Leu 
        275                 280                 285             


Glu Ile Arg Val Ile Asp Leu Asp Glu Glu Phe Ser Ala Asn Trp Met 
    290                 295                 300                 


Ala Val Ile Phe Phe Ile Ser Gly Asn Glu Gly Asn Trp Phe Glu Ile 
305                 310                 315                 320 


Glu Met Asn Glu Arg Thr Asn Val Gly Ile Leu Lys Val Val Lys Pro 
                325                 330                 335     


Leu Asp Tyr Glu Ala Met Gln Ser Leu Gln Leu Ser Ile Gly Val Arg 
            340                 345                 350         


Asn Lys Ala Glu Phe His His Ser Ile Met Ser Gln Tyr Lys Leu Lys 
        355                 360                 365             


Ala Ser Ala Ile Ser Val Thr Val Leu Asn Val Ile Glu Gly Pro Val 
    370                 375                 380                 


Phe Arg Pro Gly Ser Lys Thr Tyr Val Val Thr Gly Asn Met Gly Ser 
385                 390                 395                 400 


Asn Asp Lys Val Gly Asp Phe Val Ala Thr Asp Leu Asp Thr Gly Arg 
                405                 410                 415     


Pro Ser Thr Thr Val Arg Tyr Val Met Gly Asn Asn Pro Ala Asp Leu 
            420                 425                 430         


Leu Ala Val Asp Ser Arg Thr Gly Lys Leu Thr Leu Lys Asn Lys Val 
        435                 440                 445             


Thr Lys Glu Gln Tyr Asn Met Leu Gly Gly Lys Tyr Gln Gly Thr Ile 
    450                 455                 460                 


Leu Ser Ile Asp Asp Asn Leu Gln Arg Thr Cys Thr Gly Thr Ile Asn 
465                 470                 475                 480 


Ile Asn Ile Gln Ser Phe Gly Asn Asp Asp Arg Thr Asn Thr Glu Pro 
                485                 490                 495     


Asn Thr Lys Ile Thr Thr Asn Thr Gly Arg Gln Glu Ser Thr Ser Ser 
            500                 505                 510         


Thr Asn Tyr Asp Thr Ser Thr Thr Ser Thr Asp Ser Ser Gln Val Tyr 
        515                 520                 525             


Ser Ser Glu Pro Gly Asn Gly Ala Lys Asp Leu Leu Ser Asp Asn Val 
    530                 535                 540                 


His Phe Gly Pro Ala Gly Ile Gly Leu Leu Ile Met Gly Phe Leu Val 
545                 550                 555                 560 


Leu Gly Leu Val Pro Phe Leu Met Ile Cys Cys Asp Cys Gly Gly Ala 
                565                 570                 575     


Pro Arg Ser Ala Ala Gly Phe Glu Pro Val Pro Glu Cys Ser Asp Gly 
            580                 585                 590         


Ala Ile His Ser Trp Ala Val Glu Gly Pro Gln Pro Glu Pro Arg Asp 
        595                 600                 605             


Ile Thr Thr Val Ile Pro Gln Ile Pro Pro Asp Asn Ala Asn Ile Ile 
    610                 615                 620                 


Glu Cys Ile Asp Asn Ser Gly Val Tyr Thr Asn Glu Tyr Gly Gly Arg 
625                 630                 635                 640 


Glu Met Gln Asp Leu Gly Gly Gly Glu Arg Met Thr Gly Phe Glu Leu 
                645                 650                 655     


Thr Glu Gly Val Lys Thr Ser Gly Met Pro Glu Ile Cys Gln Glu Tyr 
            660                 665                 670         


Ser Gly Thr Leu Arg Arg Asn Ser Met Arg Glu Cys Arg Glu Gly Gly 
        675                 680                 685             


Leu Asn Met Asn Phe Met Glu Ser Tyr Phe Cys Gln Lys Ala Tyr Ala 
    690                 695                 700                 


Tyr Ala Asp Glu Asp Glu Gly Arg Pro Ser Asn Asp Cys Leu Leu Ile 
705                 710                 715                 720 


Tyr Asp Ile Glu Gly Val Gly Ser Pro Ala Gly Ser Val Gly Cys Cys 
                725                 730                 735     


Ser Phe Ile Gly Glu Asp Leu Asp Asp Ser Phe Leu Asp Thr Leu Gly 
            740                 745                 750         


Pro Lys Phe Lys Lys Leu Ala Asp Ile Ser Leu Gly Lys Glu Ser Tyr 
        755                 760                 765             


Pro Asp Leu Asp Pro Ser Trp Pro Pro Gln Ser Thr Glu Pro Val Cys 
    770                 775                 780                 


Leu Pro Gln Glu Thr Glu Pro Val Val Ser Gly His Pro Pro Ile Ser 
785                 790                 795                 800 


Pro His Phe Gly Thr Thr Thr Val Ile Ser Glu Ser Thr Tyr Pro Ser 
                805                 810                 815     


Gly Pro Gly Val Leu His Pro Lys Pro Ile Leu Asp Pro Leu Gly Tyr 
            820                 825                 830         


Gly Asn Val Thr Val Thr Glu Ser Tyr Thr Thr Ser Asp Thr Leu Lys 
        835                 840                 845             


Pro Ser Val His Val His Asp Asn Arg Pro Ala Ser Asn Val Val Val 
    850                 855                 860                 


Thr Glu Arg Val Val Gly Pro Ile Ser Gly Ala Asp Leu His Gly Met 
865                 870                 875                 880 


Leu Glu Met Pro Asp Leu Arg Asp Gly Ser Asn Val Ile Val Thr Glu 
                885                 890                 895     


Arg Val Ile Ala Pro Ser Ser Ser Leu Pro Thr Ser Leu Thr Ile His 
            900                 905                 910         


His Pro Arg Glu Ser Ser Asn Val Val Val Thr Glu Arg Val Ile Gln 
        915                 920                 925             


Pro Thr Ser Gly Met Ile Gly Ser Leu Ser Met His Pro Glu Leu Ala 
    930                 935                 940                 


Asn Ala His Asn Val Ile Val Thr Glu Arg Val Val Ser Gly Ala Gly 
945                 950                 955                 960 


Val Thr Gly Ile Ser Gly Thr Thr Gly Ile Ser Gly Gly Ile Gly Ser 
                965                 970                 975     


Ser Gly Leu Val Gly Thr Ser Met Gly Ala Gly Ser Gly Ala Leu Ser 
            980                 985                 990         


Gly Ala Gly Ile Ser Gly Gly Gly  Ile Gly Leu Ser Ser  Leu Gly Gly 
        995                 1000                 1005             


Thr Ala  Ser Ile Gly His Met  Arg Ser Ser Ser Asp  His His Phe 
    1010                 1015                 1020             


Asn Gln  Thr Ile Gly Ser Ala  Ser Pro Ser Thr Ala  Arg Ser Arg 
    1025                 1030                 1035             


Ile Thr  Lys Tyr Ser Thr Val  Gln Tyr Ser Lys 
    1040                 1045                 


<210>  147
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210>  148
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ser Asn Gly Tyr Glu Asp His Met Ala Glu Asp Cys Arg Gly Asp 
1               5                   10                  15      


Ile Gly Arg Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr 
            20                  25                  30          


Gln Asp Glu Leu Arg Ser Leu Phe Ser Ser Ile Gly Glu Val Glu Ser 
        35                  40                  45              


Ala Lys Leu Ile Arg Asp Lys Val Ala Gly His Ser Leu Gly Tyr Gly 
    50                  55                  60                  


Phe Val Asn Tyr Val Thr Ala Lys Asp Ala Glu Arg Ala Ile Asn Thr 
65                  70                  75                  80  


Leu Asn Gly Leu Arg Leu Gln Ser Lys Thr Ile Lys Val Ser Tyr Ala 
                85                  90                  95      


Arg Pro Ser Ser Glu Val Ile Lys Asp Ala Asn Leu Tyr Ile Ser Gly 
            100                 105                 110         


Leu Pro Arg Thr Met Thr Gln Lys Asp Val Glu Asp Met Phe Ser Arg 
        115                 120                 125             


Phe Gly Arg Ile Ile Asn Ser Arg Val Leu Val Asp Gln Thr Thr Gly 
    130                 135                 140                 


Leu Ser Arg Gly Val Ala Phe Ile Arg Phe Asp Lys Arg Ser Glu Ala 
145                 150                 155                 160 


Glu Glu Ala Ile Thr Ser Phe Asn Gly His Lys Pro Pro Gly Ser Ser 
                165                 170                 175     


Glu Pro Ile Thr Val Lys Phe Ala Ala Asn Pro Asn Gln Asn Lys Asn 
            180                 185                 190         


Val Ala Leu Leu Ser Gln Leu Tyr His Ser Pro Ala Arg Arg Phe Gly 
        195                 200                 205             


Gly Pro Val His His Gln Ala Gln Arg Phe Arg Phe Ser Pro Met Gly 
    210                 215                 220                 


Val Asp His Met Ser Gly Leu Ser Gly Val Asn Val Pro Gly Asn Ala 
225                 230                 235                 240 


Ser Ser Gly Trp Cys Ile Phe Ile Tyr Asn Leu Gly Gln Asp Ala Asp 
                245                 250                 255     


Glu Gly Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn 
            260                 265                 270         


Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly 
        275                 280                 285             


Phe Val Thr Met Thr Asn Tyr Glu Glu Ala Ala Met Ala Ile Ala Ser 
    290                 295                 300                 


Leu Asn Gly Tyr Arg Leu Gly Asp Lys Ile Leu Gln Val Ser Phe Lys 
305                 310                 315                 320 


Thr Asn Lys Ser His Lys 
                325     


<210>  149
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Ser Val Gly Phe Ile Gly Ala Gly Gln Leu Ala Phe Ala Leu Ala 
1               5                   10                  15      


Lys Gly Phe Thr Ala Ala Gly Val Leu Ala Ala His Lys Ile Met Ala 
            20                  25                  30          


Ser Ser Pro Asp Met Asp Leu Ala Thr Val Ser Ala Leu Arg Lys Met 
        35                  40                  45              


Gly Val Lys Leu Thr Pro His Asn Lys Glu Thr Val Gln His Ser Asp 
    50                  55                  60                  


Val Leu Phe Leu Ala Val Lys Pro His Ile Ile Pro Phe Ile Leu Asp 
65                  70                  75                  80  


Glu Ile Gly Ala Asp Ile Glu Asp Arg His Ile Val Val Ser Cys Ala 
                85                  90                  95      


Ala Gly Val Thr Ile Ser Ser Ile Glu Lys Lys Leu Ser Ala Phe Arg 
            100                 105                 110         


Pro Ala Pro Arg Val Ile Arg Cys Met Thr Asn Thr Pro Val Val Val 
        115                 120                 125             


Arg Glu Gly Ala Thr Val Tyr Ala Thr Gly Thr His Ala Gln Val Glu 
    130                 135                 140                 


Asp Gly Arg Leu Met Glu Gln Leu Leu Ser Ser Val Gly Phe Cys Thr 
145                 150                 155                 160 


Glu Val Glu Glu Asp Leu Ile Asp Ala Val Thr Gly Leu Ser Gly Ser 
                165                 170                 175     


Gly Pro Ala Tyr Ala Phe Thr Ala Leu Asp Ala Leu Ala Asp Gly Gly 
            180                 185                 190         


Val Lys Met Gly Leu Pro Arg Arg Leu Ala Val Arg Leu Gly Ala Gln 
        195                 200                 205             


Ala Leu Leu Gly Ala Ala Lys Met Leu Leu His Ser Glu Gln His Pro 
    210                 215                 220                 


Gly Gln Leu Lys Asp Asn Val Ser Ser Pro Gly Gly Ala Thr Ile His 
225                 230                 235                 240 


Ala Leu His Val Leu Glu Ser Gly Gly Phe Arg Ser Leu Leu Ile Asn 
                245                 250                 255     


Ala Val Glu Ala Ser Cys Ile Arg Thr Arg Glu Leu Gln Ser Met Ala 
            260                 265                 270         


Asp Gln Glu Gln Val Ser Pro Ala Ala Ile Lys Lys Thr Ile Leu Asp 
        275                 280                 285             


Lys Val Lys Leu Asp Ser Pro Ala Gly Thr Ala Leu Ser Pro Ser Gly 
    290                 295                 300                 


His Thr Lys Leu Leu Pro Arg Ser Leu Ala Pro Ala Gly Lys Asp 
305                 310                 315                 


<210>  150
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  150

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Phe Gly Ser Ser Ser Asn Ile Gly Arg Tyr 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Thr Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu Ser 
            100                 105                 


<210>  151
<211>  871
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Ser Phe Ser Glu Met Asn Arg Arg Thr Leu Ala Phe Arg Gly Gly 
1               5                   10                  15      


Gly Leu Val Thr Ala Ser Gly Gly Gly Ser Thr Asn Asn Asn Ala Gly 
            20                  25                  30          


Gly Glu Ala Ser Ala Trp Pro Pro Gln Pro Gln Pro Arg Gln Pro Pro 
        35                  40                  45              


Pro Pro Ala Pro Pro Ala Leu Gln Pro Pro Asn Gly Arg Gly Ala Asp 
    50                  55                  60                  


Glu Glu Val Glu Leu Glu Gly Leu Glu Pro Gln Asp Leu Glu Ala Ser 
65                  70                  75                  80  


Ala Gly Pro Ala Ala Gly Ala Ala Glu Glu Ala Lys Glu Leu Leu Leu 
                85                  90                  95      


Pro Gln Asp Ala Gly Gly Pro Thr Ser Leu Gly Gly Gly Ala Gly Gly 
            100                 105                 110         


Pro Leu Leu Ala Glu Arg Asn Arg Arg Thr Leu Ala Phe Arg Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Leu Gly Asn Asn Gly Ser Ser Arg Gly Arg Pro Glu 
    130                 135                 140                 


Thr Ser Val Trp Pro Leu Arg His Phe Asn Gly Arg Gly Pro Ala Thr 
145                 150                 155                 160 


Val Asp Leu Glu Leu Asp Ala Leu Glu Gly Lys Glu Leu Met Gln Asp 
                165                 170                 175     


Gly Ala Ser Leu Ser Asp Ser Thr Glu Asp Glu Glu Glu Gly Ala Ser 
            180                 185                 190         


Leu Gly Asp Gly Ser Gly Ala Glu Gly Gly Ser Cys Ser Ser Ser Arg 
        195                 200                 205             


Arg Ser Gly Gly Asp Gly Gly Asp Glu Val Glu Gly Ser Gly Val Gly 
    210                 215                 220                 


Ala Gly Glu Gly Glu Thr Val Gln His Phe Pro Leu Ala Arg Pro Lys 
225                 230                 235                 240 


Ser Leu Met Gln Lys Leu Gln Cys Ser Phe Gln Thr Ser Trp Leu Lys 
                245                 250                 255     


Asp Phe Pro Trp Leu Arg Tyr Ser Lys Asp Thr Gly Leu Met Ser Cys 
            260                 265                 270         


Gly Trp Cys Gln Lys Thr Pro Ala Asp Gly Gly Ser Val Asp Leu Pro 
        275                 280                 285             


Pro Val Gly His Asp Glu Leu Ser Arg Gly Thr Arg Asn Tyr Lys Lys 
    290                 295                 300                 


Thr Leu Leu Leu Arg His His Val Ser Thr Glu His Lys Leu His Glu 
305                 310                 315                 320 


Ala Asn Ala Gln Glu Ser Glu Ile Pro Ser Glu Glu Gly Tyr Cys Asp 
                325                 330                 335     


Phe Asn Ser Arg Pro Asn Glu Asn Ser Tyr Cys Tyr Gln Leu Leu Arg 
            340                 345                 350         


Gln Leu Asn Glu Gln Arg Lys Lys Gly Ile Leu Cys Asp Val Ser Ile 
        355                 360                 365             


Val Val Ser Gly Lys Ile Phe Lys Ala His Lys Asn Ile Leu Val Ala 
    370                 375                 380                 


Gly Ser Arg Phe Phe Lys Thr Leu Tyr Cys Phe Ser Asn Lys Glu Ser 
385                 390                 395                 400 


Pro Asn Gln Asn Asn Thr Thr His Leu Asp Ile Ala Ala Val Gln Gly 
                405                 410                 415     


Phe Ser Val Ile Leu Asp Phe Leu Tyr Ser Gly Asn Leu Val Leu Thr 
            420                 425                 430         


Ser Gln Asn Ala Ile Glu Val Met Thr Val Ala Ser Tyr Leu Gln Met 
        435                 440                 445             


Ser Glu Val Val Gln Thr Cys Arg Asn Phe Ile Lys Asp Ala Leu Asn 
    450                 455                 460                 


Ile Ser Ile Lys Ser Glu Ala Pro Glu Ser Val Val Val Asp Tyr Asn 
465                 470                 475                 480 


Asn Arg Lys Pro Val Asn Arg Asp Gly Leu Ser Ser Ser Arg Asp Gln 
                485                 490                 495     


Lys Ile Ala Ser Phe Trp Ala Thr Arg Asn Leu Thr Asn Leu Ala Ser 
            500                 505                 510         


Asn Val Lys Ile Glu Asn Asp Gly Cys Asn Val Asp Glu Gly Gln Ile 
        515                 520                 525             


Glu Asn Tyr Gln Met Asn Asp Ser Ser Trp Val Gln Asp Gly Ser Pro 
    530                 535                 540                 


Glu Met Ala Glu Asn Glu Ser Glu Gly Gln Thr Lys Val Phe Ile Trp 
545                 550                 555                 560 


Asn Asn Met Gly Ser Gln Gly Ile Gln Glu Thr Gly Lys Thr Arg Arg 
                565                 570                 575     


Lys Asn Gln Thr Thr Lys Arg Phe Ile Tyr Asn Ile Pro Pro Asn Asn 
            580                 585                 590         


Glu Thr Asn Leu Glu Asp Cys Ser Val Met Gln Pro Pro Val Ala Tyr 
        595                 600                 605             


Pro Glu Glu Asn Thr Leu Leu Ile Lys Glu Glu Pro Asp Leu Asp Gly 
    610                 615                 620                 


Ala Leu Leu Ser Gly Pro Asp Gly Asp Arg Asn Val Asn Ala Asn Leu 
625                 630                 635                 640 


Leu Ala Glu Ala Gly Thr Ser Gln Asp Gly Gly Asp Ala Gly Thr Ser 
                645                 650                 655     


His Asp Phe Lys Tyr Gly Leu Met Pro Gly Pro Ser Asn Asp Phe Lys 
            660                 665                 670         


Tyr Gly Leu Ile Pro Gly Thr Ser Asn Asp Phe Lys Tyr Gly Leu Ile 
        675                 680                 685             


Pro Gly Ala Ser Asn Asp Phe Lys Tyr Gly Leu Leu Pro Glu Ser Trp 
    690                 695                 700                 


Pro Lys Gln Glu Thr Trp Glu Asn Gly Glu Ser Ser Leu Ile Met Asn 
705                 710                 715                 720 


Lys Leu Lys Cys Pro His Cys Ser Tyr Val Ala Lys Tyr Arg Arg Thr 
                725                 730                 735     


Leu Lys Arg His Leu Leu Ile His Thr Gly Val Arg Ser Phe Ser Cys 
            740                 745                 750         


Asp Ile Cys Gly Lys Leu Phe Thr Arg Arg Glu His Val Lys Arg His 
        755                 760                 765             


Ser Leu Val His Lys Lys Asp Lys Lys Tyr Lys Cys Met Val Cys Lys 
    770                 775                 780                 


Lys Ile Phe Met Leu Ala Ala Ser Val Gly Ile Arg His Gly Ser Arg 
785                 790                 795                 800 


Arg Tyr Gly Val Cys Val Asp Cys Ala Asp Lys Ser Gln Pro Gly Gly 
                805                 810                 815     


Gln Glu Gly Val Asp Gln Gly Gln Asp Thr Glu Phe Pro Arg Asp Glu 
            820                 825                 830         


Glu Tyr Glu Glu Asn Glu Val Gly Glu Ala Asp Glu Glu Leu Val Asp 
        835                 840                 845             


Asp Gly Glu Asp Gln Asn Asp Pro Ser Arg Trp Asp Glu Ser Gly Glu 
    850                 855                 860                 


Val Cys Met Ser Leu Asp Asp 
865                 870     


<210>  152
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  153
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Ala Thr Glu Glu Phe Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile 
1               5                   10                  15      


His Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro 
            20                  25                  30          


Lys Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Met 
        35                  40                  45              


Arg Met Val Thr Val Pro Pro Arg His Tyr Cys Thr Val Ala Asn Pro 
    50                  55                  60                  


Val Ser Arg Asp Ala Gln Gly Leu Val Leu Phe Asp Val Thr Gly Gln 
65                  70                  75                  80  


Val Arg Leu Arg His Ala Asp Leu Glu Ile Arg Leu Ala Gln Asp Pro 
                85                  90                  95      


Phe Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu 
            100                 105                 110         


Gln Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp 
        115                 120                 125             


Phe Glu Asp Lys Asp Gly Asp Lys Val Val Ala Gly Asp Glu Trp Leu 
    130                 135                 140                 


Phe Glu Gly Pro Gly Thr Tyr Ile Pro Arg Lys Glu Val Glu Val Val 
145                 150                 155                 160 


Glu Ile Ile Gln Ala Thr Ile Ile Arg Gln Asn Gln Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Arg Lys Glu Cys Trp Asp Arg Asp Gly Lys Glu Arg Val Thr 
            180                 185                 190         


Gly Glu Glu Trp Leu Val Thr Thr Val Gly Ala Tyr Leu Pro Ala Val 
        195                 200                 205             


Phe Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys 
    210                 215                 220                 


Thr Ala Leu His Leu Arg Ala Arg Arg Asn Phe Arg Asp Phe Arg Gly 
225                 230                 235                 240 


Val Ser Arg Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr 
                245                 250                 255     


Glu Ala His Val Pro Asp Val His Glu Glu Val Leu Gly Val Val Pro 
            260                 265                 270         


Ile Thr Thr Leu Gly Pro His Asn Tyr Cys Val Ile Leu Asp Pro Val 
        275                 280                 285             


Gly Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly 
    290                 295                 300                 


Glu Lys Ser Phe Phe Leu Gln Pro Gly Glu Gln Leu Glu Gln Gly Ile 
305                 310                 315                 320 


Gln Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Arg Ala 
                325                 330                 335     


Leu Gln Pro Leu Glu Glu Gly Glu Asp Glu Glu Lys Val Ser His Gln 
            340                 345                 350         


Ala Gly Asp His Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser 
        355                 360                 365             


Ala Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Glu 
    370                 375                 380                 


Asn Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala 
385                 390                 395                 400 


Val Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu 
                405                 410                 415     


Lys Glu Leu Pro Pro Gly Val Glu Glu Leu Leu Asn Lys Gly Gln Asp 
            420                 425                 430         


Pro Leu Ala Asp Arg Gly Glu Lys Asp Thr Ala Lys Ser Leu Gln Pro 
        435                 440                 445             


Leu Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His 
    450                 455                 460                 


Asn Ala Ala Val Gln Val Tyr Asp Tyr Arg Glu Lys Arg Ala Arg Val 
465                 470                 475                 480 


Val Phe Gly Pro Glu Leu Val Ser Leu Gly Pro Glu Glu Gln Phe Thr 
                485                 490                 495     


Val Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg 
            500                 505                 510         


Ala Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr 
        515                 520                 525             


Ile Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn 
    530                 535                 540                 


Trp His Phe Glu Val Asn Asp Arg Lys Asp Pro Gln Glu Thr Ala Lys 
545                 550                 555                 560 


Leu Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala 
                565                 570                 575     


Ser Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His 
            580                 585                 590         


Lys Asn Ser Ala Arg Ile Ile Arg Thr Ala Val Phe Gly Phe Glu Thr 
        595                 600                 605             


Ser Glu Ala Lys Gly Pro Asp Gly Met Ala Leu Pro Arg Pro Arg Asp 
    610                 615                 620                 


Gln Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val 
625                 630                 635                 640 


Gln Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg 
                645                 650                 655     


Ser Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala 
            660                 665                 670         


Ala Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu 
        675                 680                 685             


Glu Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys 
    690                 695                 700                 


Glu Leu Leu Glu Leu Glu Ala Leu Ser Met Ala Val Glu Ser Thr Gly 
705                 710                 715                 720 


Thr Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu 
                725                 730                 735     


Gly Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala 
            740                 745                 750         


Ile Glu Thr Glu Ala Glu Leu Gln Arg Val Gln Lys Val Arg Glu Leu 
        755                 760                 765             


Glu Leu Val Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala 
    770                 775                 780                 


Gln Gln Leu Ala Glu Val Glu Val Lys Lys Phe Lys Gln Met Thr Glu 
785                 790                 795                 800 


Ala Ile Gly Pro Ser Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu 
                805                 810                 815     


Met Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile 
            820                 825                 830         


Thr Asp Gly Ser Thr Pro Ile Asn Leu Phe Asn Thr Ala Phe Gly Leu 
        835                 840                 845             


Leu Gly Met Gly Pro Glu Gly Gln Pro Leu Gly Arg Arg Val Ala Ser 
    850                 855                 860                 


Gly Pro Ser Pro Gly Glu Gly Ile Ser Pro Gln Ser Ala Gln Ala Pro 
865                 870                 875                 880 


Gln Ala Pro Gly Asp Asn His Val Val Pro Val Leu Arg 
                885                 890             


<210>  154
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe 
            20                  25                  30          


Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
        35                  40                  45              


Val Ile Leu Val Pro Gly Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu 
    50                  55                  60                  


Asp Lys Pro Asp Val Val Asn Trp Met Cys Tyr Arg Lys Thr Glu Asp 
65                  70                  75                  80  


Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu Pro Leu Gly Val 
                85                  90                  95      


Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly 
            100                 105                 110         


Leu Val Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly 
        115                 120                 125             


Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser Ser Lys Leu Ala Gly Tyr 
    130                 135                 140                 


Leu His Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp 
145                 150                 155                 160 


Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Glu Pro Gly Gln 
                165                 170                 175     


Gln Glu Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His 
            180                 185                 190         


Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys 
        195                 200                 205             


Leu His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp 
    210                 215                 220                 


Arg Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser 
225                 230                 235                 240 


Ile Lys Pro Met Leu Val Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro 
                245                 250                 255     


Ile Met Ser Ser Ile Lys Leu Lys Glu Glu Gln Arg Ile Thr Thr Thr 
            260                 265                 270         


Ser Pro Trp Met Phe Pro Ser Arg Met Ala Trp Pro Glu Asp His Val 
        275                 280                 285             


Phe Ile Ser Thr Pro Ser Phe Asn Tyr Thr Gly Arg Asp Phe Gln Arg 
    290                 295                 300                 


Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp Tyr Met Trp Leu Gln 
305                 310                 315                 320 


Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr 
                325                 330                 335     


Cys Leu Tyr Gly Val Gly Leu Pro Thr Pro Arg Thr Tyr Ile Tyr Asp 
            340                 345                 350         


His Gly Phe Pro Tyr Thr Asp Pro Val Gly Val Leu Tyr Glu Asp Gly 
        355                 360                 365             


Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Leu Trp Gln 
    370                 375                 380                 


Gly Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln 
385                 390                 395                 400 


His Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala 
                405                 410                 415     


Ile Leu Leu Gly Ala Tyr Arg Gln Gly Pro Pro Ala Ser Pro Thr Ala 
            420                 425                 430         


Ser Pro Glu Pro Pro Pro Pro Glu 
        435                 440 


<210>  155
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  156
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ala Glu Leu Val Gln Gly Gln Ser Ala Pro Val Gly Met Lys Ala 
1               5                   10                  15      


Glu Gly Phe Val Asp Ala Leu His Arg Val Arg Gln Ile Ala Ala Lys 
            20                  25                  30          


Ile Asp Ser Ile Pro His Leu Asn Asn Ser Thr Pro Leu Val Asp Pro 
        35                  40                  45              


Ser Val Tyr Gly Tyr Gly Val Gln Lys Arg Pro Leu Asp Asp Gly Val 
    50                  55                  60                  


Gly Asn Gln Leu Gly Ala Leu Val His Gln Arg Thr Val Ile Thr Glu 
65                  70                  75                  80  


Glu Phe Lys Val Pro Asp Lys Met Val Gly Phe Ile Ile Gly Arg Gly 
                85                  90                  95      


Gly Glu Gln Ile Ser Arg Ile Gln Ala Glu Ser Gly Cys Lys Ile Gln 
            100                 105                 110         


Ile Ala Ser Glu Ser Ser Gly Ile Pro Glu Arg Pro Cys Val Leu Thr 
        115                 120                 125             


Gly Thr Pro Glu Ser Ile Glu Gln Ala Lys Arg Leu Leu Gly Gln Ile 
    130                 135                 140                 


Val Asp Arg Cys Arg Asn Gly Pro Gly Phe His Asn Asp Ile Asp Ser 
145                 150                 155                 160 


Asn Ser Thr Ile Gln Glu Ile Leu Ile Pro Ala Ser Lys Val Gly Leu 
                165                 170                 175     


Val Ile Gly Arg Gly Gly Glu Thr Ile Lys Gln Leu Gln Glu Arg Thr 
            180                 185                 190         


Gly Val Lys Met Val Met Ile Gln Asp Gly Pro Leu Pro Thr Gly Ala 
        195                 200                 205             


Asp Lys Pro Leu Arg Ile Thr Gly Asp Ala Phe Lys Val Gln Gln Ala 
    210                 215                 220                 


Arg Glu Met Val Leu Glu Ile Ile Arg Glu Lys Asp Gln Ala Asp Phe 
225                 230                 235                 240 


Arg Gly Val Arg Gly Asp Phe Asn Ser Arg Met Gly Gly Gly Ser Ile 
                245                 250                 255     


Glu Val Ser Val Pro Arg Phe Ala Val Gly Ile Val Ile Gly Arg Asn 
            260                 265                 270         


Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala Gly Val Arg Ile Gln 
        275                 280                 285             


Phe Lys Pro Asp Asp Gly Ile Ser Pro Glu Arg Ala Ala Gln Val Met 
    290                 295                 300                 


Gly Pro Pro Asp Arg Cys Gln His Ala Ala His Ile Ile Ser Glu Leu 
305                 310                 315                 320 


Ile Leu Thr Ala Gln Glu Arg Asp Gly Phe Gly Gly Leu Ala Ala Ala 
                325                 330                 335     


Arg Gly Arg Gly Arg Gly Arg Gly Asp Trp Ser Val Gly Ala Pro Gly 
            340                 345                 350         


Gly Val Gln Glu Ile Thr Tyr Thr Val Pro Ala Asp Lys Cys Gly Leu 
        355                 360                 365             


Val Ile Gly Lys Gly Gly Glu Asn Ile Lys Ser Ile Asn Gln Gln Ser 
    370                 375                 380                 


Gly Ala His Val Glu Leu Gln Arg Asn Pro Pro Pro Asn Ser Asp Pro 
385                 390                 395                 400 


Asn Leu Arg Arg Phe Thr Ile Arg Gly Val Pro Gln Gln Ile Glu Val 
                405                 410                 415     


Ala Arg Gln Leu Ile Asp Glu Lys Val Gly Gly Thr Asn Leu Gly Ala 
            420                 425                 430         


Pro Gly Ala Phe Gly Gln Ser Pro Phe Ser Gln Pro Pro Ala Pro Pro 
        435                 440                 445             


His Gln Asn Thr Phe Pro Pro Arg Ser Ser Gly Cys Phe Pro Asn Met 
    450                 455                 460                 


Ala Ala Lys Val Asn Gly Asn Pro His Ser Thr Pro Val Ser Gly Pro 
465                 470                 475                 480 


Pro Ala Phe Leu Thr Gln Gly Trp Gly Ser Thr Tyr Gln Ala Trp Gln 
                485                 490                 495     


Gln Pro Thr Gln Gln Val Pro Ser Gln Gln Ser Gln Pro Gln Ser Ser 
            500                 505                 510         


Gln Pro Asn Tyr Ser Lys Ala Trp Glu Asp Tyr Tyr Lys Lys Gln Ser 
        515                 520                 525             


His Ala Ala Ser Ala Ala Pro Gln Ala Ser Ser Pro Pro Asp Tyr Thr 
    530                 535                 540                 


Met Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Val Ala Phe Tyr Gly Gln 
545                 550                 555                 560 


Thr Leu Gly Gln Ala Gln Ala His Ser Gln Glu Gln 
                565                 570         


<210>  157
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  157

Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
            100                 105                 110         


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 
        115                 120                 125             


Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
    130                 135                 140                 


Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
145                 150                 155                 160 


Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
                165                 170                 175     


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            180                 185                 190         


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        195                 200                 205             


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    210                 215                 220                 


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
225                 230                 235                 240 


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                245                 250                 255     


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 
            260                 265                 270         


Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 
        275                 280                 285             


Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 
    290                 295                 300                 


Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 
305                 310                 315                 320 


Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala 
                325                 330                 335     


Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 
            340                 345                 350         


Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 
        355                 360                 365             


Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380                 


<210>  158
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gln Leu Phe Leu Leu Leu Cys Leu Val Leu Leu Ser Pro Gln Gly 
1               5                   10                  15      


Ala Ser Leu His Arg His His Pro Arg Glu Met Lys Lys Arg Val Glu 
            20                  25                  30          


Asp Leu His Val Gly Ala Thr Val Ala Pro Ser Ser Arg Arg Asp Phe 
        35                  40                  45              


Thr Phe Asp Leu Tyr Arg Ala Leu Ala Ser Ala Ala Pro Ser Gln Ser 
    50                  55                  60                  


Ile Phe Phe Ser Pro Val Ser Ile Ser Met Ser Leu Ala Met Leu Ser 
65                  70                  75                  80  


Leu Gly Ala Gly Ser Ser Thr Lys Met Gln Ile Leu Glu Gly Leu Gly 
                85                  90                  95      


Leu Asn Leu Gln Lys Ser Ser Glu Lys Glu Leu His Arg Gly Phe Gln 
            100                 105                 110         


Gln Leu Leu Gln Glu Leu Asn Gln Pro Arg Asp Gly Phe Gln Leu Ser 
        115                 120                 125             


Leu Gly Asn Ala Leu Phe Thr Asp Leu Val Val Asp Leu Gln Asp Thr 
    130                 135                 140                 


Phe Val Ser Ala Met Lys Thr Leu Tyr Leu Ala Asp Thr Phe Pro Thr 
145                 150                 155                 160 


Asn Phe Arg Asp Ser Ala Gly Ala Met Lys Gln Ile Asn Asp Tyr Val 
                165                 170                 175     


Ala Lys Gln Thr Lys Gly Lys Ile Val Asp Leu Leu Lys Asn Leu Asp 
            180                 185                 190         


Ser Asn Ala Val Val Ile Met Val Asn Tyr Ile Phe Phe Lys Ala Lys 
        195                 200                 205             


Trp Glu Thr Ser Phe Asn His Lys Gly Thr Gln Glu Gln Asp Phe Tyr 
    210                 215                 220                 


Val Thr Ser Glu Thr Val Val Arg Val Pro Met Met Ser Arg Glu Asp 
225                 230                 235                 240 


Gln Tyr His Tyr Leu Leu Asp Arg Asn Leu Ser Cys Arg Val Val Gly 
                245                 250                 255     


Val Pro Tyr Gln Gly Asn Ala Thr Ala Leu Phe Ile Leu Pro Ser Glu 
            260                 265                 270         


Gly Lys Met Gln Gln Val Glu Asn Gly Leu Ser Glu Lys Thr Leu Arg 
        275                 280                 285             


Lys Trp Leu Lys Met Phe Lys Lys Arg Gln Leu Glu Leu Tyr Leu Pro 
    290                 295                 300                 


Lys Phe Ser Ile Glu Gly Ser Tyr Gln Leu Glu Lys Val Leu Pro Ser 
305                 310                 315                 320 


Leu Gly Ile Ser Asn Val Phe Thr Ser His Ala Asp Leu Ser Gly Ile 
                325                 330                 335     


Ser Asn His Ser Asn Ile Gln Val Ser Glu Met Val His Lys Ala Val 
            340                 345                 350         


Val Glu Val Asp Glu Ser Gly Thr Arg Ala Ala Ala Ala Thr Gly Thr 
        355                 360                 365             


Ile Phe Thr Phe Arg Ser Ala Arg Leu Asn Ser Gln Arg Leu Val Phe 
    370                 375                 380                 


Asn Arg Pro Phe Leu Met Phe Ile Val Asp Asn Asn Ile Leu Phe Leu 
385                 390                 395                 400 


Gly Lys Val Asn Arg Pro 
                405     


<210>  159
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Ala Asn Gln Val Asn Gly Asn Ala Val Gln Leu Lys Glu Glu Glu 
1               5                   10                  15      


Glu Pro Met Asp Thr Ser Ser Val Thr His Thr Glu His Tyr Lys Thr 
            20                  25                  30          


Leu Ile Glu Ala Gly Leu Pro Gln Lys Val Ala Glu Arg Leu Asp Glu 
        35                  40                  45              


Ile Phe Gln Thr Gly Leu Val Ala Tyr Val Asp Leu Asp Glu Arg Ala 
    50                  55                  60                  


Ile Asp Ala Leu Arg Glu Phe Asn Glu Glu Gly Ala Leu Ser Val Leu 
65                  70                  75                  80  


Gln Gln Phe Lys Glu Ser Asp Leu Ser His Val Gln Asn Lys Ser Ala 
                85                  90                  95      


Phe Leu Cys Gly Val Met Lys Thr Tyr Arg Gln Arg Glu Lys Gln Gly 
            100                 105                 110         


Ser Lys Val Gln Glu Ser Thr Lys Gly Pro Asp Glu Ala Lys Ile Lys 
        115                 120                 125             


Ala Leu Leu Glu Arg Thr Gly Tyr Thr Leu Asp Val Thr Thr Gly Gln 
    130                 135                 140                 


Arg Lys Tyr Gly Gly Pro Pro Pro Asp Ser Val Tyr Ser Gly Val Gln 
145                 150                 155                 160 


Pro Gly Ile Gly Thr Glu Val Phe Val Gly Lys Ile Pro Arg Asp Leu 
                165                 170                 175     


Tyr Glu Asp Glu Leu Val Pro Leu Phe Glu Lys Ala Gly Pro Ile Trp 
            180                 185                 190         


Asp Leu Arg Leu Met Met Asp Pro Leu Ser Gly Gln Asn Arg Gly Tyr 
        195                 200                 205             


Ala Phe Ile Thr Phe Cys Gly Lys Glu Ala Ala Gln Glu Ala Val Lys 
    210                 215                 220                 


Leu Cys Asp Ser Tyr Glu Ile Arg Pro Gly Lys His Leu Gly Val Cys 
225                 230                 235                 240 


Ile Ser Val Ala Asn Asn Arg Leu Phe Val Gly Ser Ile Pro Lys Asn 
                245                 250                 255     


Lys Thr Lys Glu Asn Ile Leu Glu Glu Phe Ser Lys Val Thr Glu Gly 
            260                 265                 270         


Leu Val Asp Val Ile Leu Tyr His Gln Pro Asp Asp Lys Lys Lys Asn 
        275                 280                 285             


Arg Gly Phe Cys Phe Leu Glu Tyr Glu Asp His Lys Ser Ala Ala Gln 
    290                 295                 300                 


Ala Arg Arg Arg Leu Met Ser Gly Lys Val Lys Val Trp Gly Asn Val 
305                 310                 315                 320 


Val Thr Val Glu Trp Ala Asp Pro Val Glu Glu Pro Asp Pro Glu Val 
                325                 330                 335     


Met Ala Lys Val Lys Val Leu Phe Val Arg Asn Leu Ala Thr Thr Val 
            340                 345                 350         


Thr Glu Glu Ile Leu Glu Lys Ser Phe Ser Glu Phe Gly Lys Leu Glu 
        355                 360                 365             


Arg Val Lys Lys Leu Lys Asp Tyr Ala Phe Val His Phe Glu Asp Arg 
    370                 375                 380                 


Gly Ala Ala Val Lys Ala Met Asp Glu Met Asn Gly Lys Glu Ile Glu 
385                 390                 395                 400 


Gly Glu Glu Ile Glu Ile Val Leu Ala Lys Pro Pro Asp Lys Lys Arg 
                405                 410                 415     


Lys Glu Arg Gln Ala Ala Arg Gln Ala Ser Arg Ser Thr Ala Tyr Glu 
            420                 425                 430         


Asp Tyr Tyr Tyr His Pro Pro Pro Arg Met Pro Pro Pro Ile Arg Gly 
        435                 440                 445             


Arg Gly Arg Gly Gly Gly Arg Gly Gly Tyr Gly Tyr Pro Pro Asp Tyr 
    450                 455                 460                 


Tyr Gly Tyr Glu Asp Tyr Tyr Asp Asp Tyr Tyr Gly Tyr Asp Tyr His 
465                 470                 475                 480 


Asp Tyr Arg Gly Gly Tyr Glu Asp Pro Tyr Tyr Gly Tyr Asp Asp Gly 
                485                 490                 495     


Tyr Ala Val Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Ala Pro 
            500                 505                 510         


Pro Pro Pro Arg Gly Arg Gly Ala Pro Pro Pro Arg Gly Arg Ala Gly 
        515                 520                 525             


Tyr Ser Gln Arg Gly Ala Pro Leu Gly Pro Pro Arg Gly Ser Arg Gly 
    530                 535                 540                 


Gly Arg Gly Gly Pro Ala Gln Gln Gln Arg Gly Arg Gly Ser Arg Gly 
545                 550                 555                 560 


Ser Arg Gly Asn Arg Gly Gly Asn Val Gly Gly Lys Arg Lys Ala Asp 
                565                 570                 575     


Gly Tyr Asn Gln Pro Asp Ser Lys Arg Arg Gln Thr Asn Asn Gln Gln 
            580                 585                 590         


Asn Trp Gly Ser Gln Pro Ile Ala Gln Gln Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Asp Tyr Ser Gly Asn Tyr Gly Tyr Asn Asn Asp Asn Gln Glu Phe Tyr 
    610                 615                 620                 


Gln Asp Thr Tyr Gly Gln Gln Trp Lys 
625                 630             


<210>  160
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Ala Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210>  161
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  162
<211>  1208
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Ser Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
225                 230                 235                 240 


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
                245                 250                 255     


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
            260                 265                 270         


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys 
        275                 280                 285             


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
    290                 295                 300                 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
305                 310                 315                 320 


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
                325                 330                 335     


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
            340                 345                 350         


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
        355                 360                 365             


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
    370                 375                 380                 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
385                 390                 395                 400 


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
                405                 410                 415     


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
            420                 425                 430         


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
        435                 440                 445             


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
    450                 455                 460                 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
465                 470                 475                 480 


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
                485                 490                 495     


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
            500                 505                 510         


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
        515                 520                 525             


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
    530                 535                 540                 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
545                 550                 555                 560 


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
                565                 570                 575     


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
            580                 585                 590         


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
        595                 600                 605             


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
    610                 615                 620                 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
625                 630                 635                 640 


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
                645                 650                 655     


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
            660                 665                 670         


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
        675                 680                 685             


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
    690                 695                 700                 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
705                 710                 715                 720 


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
                725                 730                 735     


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
            740                 745                 750         


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
        755                 760                 765             


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
    770                 775                 780                 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
785                 790                 795                 800 


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
                805                 810                 815     


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
            820                 825                 830         


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
        835                 840                 845             


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
    850                 855                 860                 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
865                 870                 875                 880 


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
                885                 890                 895     


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
            900                 905                 910         


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
        915                 920                 925             


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
    930                 935                 940                 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
945                 950                 955                 960 


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
                965                 970                 975     


Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr Lys Phe Tyr 
            980                 985                 990         


Leu Arg Ala Cys Thr Ser Gln Gly  Cys Gly Lys Pro Ile  Thr Glu Glu 
        995                 1000                 1005             


Ser Ser  Thr Leu Gly Glu Gly  Ser Lys Gly Ile Gly  Lys Ile Ser 
    1010                 1015                 1020             


Gly Val  Asn Leu Thr Gln Lys  Thr His Pro Ile Glu  Val Phe Glu 
    1025                 1030                 1035             


Pro Gly  Ala Glu His Ile Val  Arg Leu Met Thr Lys  Asn Trp Gly 
    1040                 1045                 1050             


Asp Asn  Asp Ser Ile Phe Gln  Asp Val Ile Glu Thr  Arg Gly Arg 
    1055                 1060                 1065             


Glu Tyr  Ala Gly Leu Tyr Asp  Asp Ile Ser Thr Gln  Gly Trp Phe 
    1070                 1075                 1080             


Ile Gly  Leu Met Cys Ala Ile  Ala Leu Leu Thr Leu  Leu Leu Leu 
    1085                 1090                 1095             


Thr Val  Cys Phe Val Lys Arg  Asn Arg Gly Gly Lys  Tyr Ser Val 
    1100                 1105                 1110             


Lys Glu  Lys Glu Asp Leu His  Pro Asp Pro Glu Ile  Gln Ser Val 
    1115                 1120                 1125             


Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp Ser Asp  Glu Lys Pro 
    1130                 1135                 1140             


Leu Lys  Gly Ser Leu Arg Ser  Leu Asn Arg Asp Met  Gln Pro Thr 
    1145                 1150                 1155             


Glu Ser  Ala Asp Ser Leu Val  Glu Tyr Gly Glu Gly  Asp His Gly 
    1160                 1165                 1170             


Leu Phe  Ser Glu Asp Gly Ser  Phe Ile Gly Ala Tyr  Ala Gly Ser 
    1175                 1180                 1185             


Lys Glu  Lys Gly Ser Val Glu  Ser Asn Gly Ser Ser  Thr Ala Thr 
    1190                 1195                 1200             


Phe Pro  Leu Arg Ala 
    1205             


<210>  163
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Gly Glu Val Glu Ala Pro Gly Arg Leu Trp Leu Glu Ser Pro Pro 
1               5                   10                  15      


Gly Gly Ala Pro Pro Ile Phe Leu Pro Ser Asp Gly Gln Ala Leu Val 
            20                  25                  30          


Leu Gly Arg Gly Pro Leu Thr Gln Val Thr Asp Arg Lys Cys Ser Arg 
        35                  40                  45              


Thr Gln Val Glu Leu Val Ala Asp Pro Glu Thr Arg Thr Val Ala Val 
    50                  55                  60                  


Lys Gln Leu Gly Val Asn Pro Ser Thr Thr Gly Thr Gln Glu Leu Lys 
65                  70                  75                  80  


Pro Gly Leu Glu Gly Ser Leu Gly Val Gly Asp Thr Leu Tyr Leu Val 
                85                  90                  95      


Asn Gly Leu His Pro Leu Thr Leu Arg Trp Glu Glu Thr Arg Thr Pro 
            100                 105                 110         


Glu Ser Gln Pro Asp Thr Pro Pro Gly Thr Pro Leu Val Ser Gln Asp 
        115                 120                 125             


Glu Lys Arg Asp Ala Glu Leu Pro Lys Lys Arg Met Arg Lys Ser Asn 
    130                 135                 140                 


Pro Gly Trp Glu Asn Leu Glu Lys Leu Leu Val Phe Thr Ala Ala Gly 
145                 150                 155                 160 


Val Lys Pro Gln Gly Lys Val Ala Gly Phe Asp Leu Asp Gly Thr Leu 
                165                 170                 175     


Ile Thr Thr Arg Ser Gly Lys Val Phe Pro Thr Gly Pro Ser Asp Trp 
            180                 185                 190         


Arg Ile Leu Tyr Pro Glu Ile Pro Arg Lys Leu Arg Glu Leu Glu Ala 
        195                 200                 205             


Glu Gly Tyr Lys Leu Val Ile Phe Thr Asn Gln Met Ser Ile Gly Arg 
    210                 215                 220                 


Gly Lys Leu Pro Ala Glu Glu Phe Lys Ala Lys Val Glu Ala Val Val 
225                 230                 235                 240 


Glu Lys Leu Gly Val Pro Phe Gln Val Leu Val Ala Thr His Ala Gly 
                245                 250                 255     


Leu Tyr Arg Lys Pro Val Thr Gly Met Trp Asp His Leu Gln Glu Gln 
            260                 265                 270         


Ala Asn Asp Gly Thr Pro Ile Ser Ile Gly Asp Ser Ile Phe Val Gly 
        275                 280                 285             


Asp Ala Ala Gly Arg Pro Ala Asn Trp Ala Pro Gly Arg Lys Lys Lys 
    290                 295                 300                 


Asp Phe Ser Cys Ala Asp Arg Leu Phe Ala Leu Asn Leu Gly Leu Pro 
305                 310                 315                 320 


Phe Ala Thr Pro Glu Glu Phe Phe Leu Lys Trp Pro Ala Ala Gly Phe 
                325                 330                 335     


Glu Leu Pro Ala Phe Asp Pro Arg Thr Val Ser Arg Ser Gly Pro Leu 
            340                 345                 350         


Cys Leu Pro Glu Ser Arg Ala Leu Leu Ser Ala Ser Pro Glu Val Val 
        355                 360                 365             


Val Ala Val Gly Phe Pro Gly Ala Gly Lys Ser Thr Phe Leu Lys Lys 
    370                 375                 380                 


His Leu Val Ser Ala Gly Tyr Val His Val Asn Arg Asp Thr Leu Gly 
385                 390                 395                 400 


Ser Trp Gln Arg Cys Val Thr Thr Cys Glu Thr Ala Leu Lys Gln Gly 
                405                 410                 415     


Lys Arg Val Ala Ile Asp Asn Thr Asn Pro Asp Ala Ala Ser Arg Ala 
            420                 425                 430         


Arg Tyr Val Gln Cys Ala Arg Ala Ala Gly Val Pro Cys Arg Cys Phe 
        435                 440                 445             


Leu Phe Thr Ala Thr Leu Glu Gln Ala Arg His Asn Asn Arg Phe Arg 
    450                 455                 460                 


Glu Met Thr Asp Ser Ser His Ile Pro Val Ser Asp Met Val Met Tyr 
465                 470                 475                 480 


Gly Tyr Arg Lys Gln Phe Glu Ala Pro Thr Leu Ala Glu Gly Phe Ser 
                485                 490                 495     


Ala Ile Leu Glu Ile Pro Phe Arg Leu Trp Val Glu Pro Arg Leu Gly 
            500                 505                 510         


Arg Leu Tyr Cys Gln Phe Ser Glu Gly 
        515                 520     


<210>  164
<211>  4074
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu 
1               5                   10                  15      


Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu 
            20                  25                  30          


Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly 
        35                  40                  45              


Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn 
    50                  55                  60                  


Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe 
65                  70                  75                  80  


Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val 
                85                  90                  95      


Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly 
            100                 105                 110         


Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr 
        115                 120                 125             


Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro 
    130                 135                 140                 


Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile 
145                 150                 155                 160 


Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser 
                165                 170                 175     


Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser 
            180                 185                 190         


Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His 
        195                 200                 205             


Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser 
    210                 215                 220                 


Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His 
225                 230                 235                 240 


Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln 
                245                 250                 255     


Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly 
            260                 265                 270         


Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala 
        275                 280                 285             


Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro 
    290                 295                 300                 


Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu 
305                 310                 315                 320 


Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp 
                325                 330                 335     


Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp 
            340                 345                 350         


Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu 
        355                 360                 365             


Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu 
    370                 375                 380                 


Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu 
385                 390                 395                 400 


His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser 
                405                 410                 415     


Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg 
            420                 425                 430         


Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly 
        435                 440                 445             


Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser 
    450                 455                 460                 


Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro 
465                 470                 475                 480 


Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg 
                485                 490                 495     


Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly 
            500                 505                 510         


Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala 
        515                 520                 525             


Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala 
    530                 535                 540                 


Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu 
545                 550                 555                 560 


Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr 
                565                 570                 575     


Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg 
            580                 585                 590         


His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp 
        595                 600                 605             


Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile 
    610                 615                 620                 


Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys 
625                 630                 635                 640 


Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp 
                645                 650                 655     


Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly 
            660                 665                 670         


Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile 
        675                 680                 685             


Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu 
    690                 695                 700                 


Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly 
705                 710                 715                 720 


Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly 
                725                 730                 735     


Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr 
            740                 745                 750         


Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu 
        755                 760                 765             


Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr 
    770                 775                 780                 


Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val 
785                 790                 795                 800 


Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu 
                805                 810                 815     


Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser 
            820                 825                 830         


Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp 
        835                 840                 845             


Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg 
    850                 855                 860                 


Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg 
865                 870                 875                 880 


Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met 
                885                 890                 895     


Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp 
            900                 905                 910         


Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly 
        915                 920                 925             


Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile 
    930                 935                 940                 


Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln 
945                 950                 955                 960 


Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser 
                965                 970                 975     


Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met 
            980                 985                 990         


His Arg Ile Leu Met Leu Val Arg  Pro Ser Gly Leu Ala  Ile Ser Ala 
        995                 1000                 1005             


Thr Gly  Glu Asp Leu Phe Leu  Asn Val Lys Pro Arg  Leu Asp Met 
    1010                 1015                 1020             


Val Glu  Pro Ser Arg Ala Ala  Asp Ile Gly Gly Leu  Trp Ala Thr 
    1025                 1030                 1035             


Ile Arg  Gly Ser Ser Leu Glu  Gly Val Ser Leu Ile  Leu Phe Gly 
    1040                 1045                 1050             


Ser Tyr  Ser Cys Ala Ile Asn  Val Ala Thr Ser Asn  Ser Ser Arg 
    1055                 1060                 1065             


Ile Gln  Cys Lys Val Pro Pro  Arg Gly Lys Asp Gly  Arg Ile Val 
    1070                 1075                 1080             


Asn Val  Thr Val Ile Arg Gly  Asp Tyr Ser Ala Val  Leu Pro Arg 
    1085                 1090                 1095             


Ala Phe  Thr Tyr Val Ser Ser  Leu Asn Pro Val Ile  Val Thr Leu 
    1100                 1105                 1110             


Ser Arg  Asn Ile Ser Asn Ile  Ala Gly Gly Glu Thr  Leu Val Ile 
    1115                 1120                 1125             


Gly Val  Ala Arg Leu Met Asn  Tyr Thr Asp Leu Asp  Val Glu Val 
    1130                 1135                 1140             


His Val  Gln Asp Ala Leu Ala  Pro Val His Thr Gln  Ser Ala Trp 
    1145                 1150                 1155             


Gly Leu  Glu Val Ala Leu Pro  Pro Leu Pro Ala Gly  Leu His Arg 
    1160                 1165                 1170             


Ile Ser  Val Ser Ile Asn Gly  Val Ser Ile His Ser  Gln Gly Val 
    1175                 1180                 1185             


Asp Leu  His Ile Gln Tyr Leu  Thr Glu Val Phe Ser  Ile Glu Pro 
    1190                 1195                 1200             


Cys Cys  Gly Ser Leu Leu Gly  Gly Thr Ile Leu Ser  Ile Ser Gly 
    1205                 1210                 1215             


Ile Gly  Phe Ser Arg Asp Pro  Ala Leu Val Trp Val  Leu Val Gly 
    1220                 1225                 1230             


Asn Arg  Ser Cys Asp Ile Val  Asn Leu Thr Glu Ala  Ser Ile Trp 
    1235                 1240                 1245             


Cys Glu  Thr Leu Pro Ala Pro  Gln Ile Pro Asp Ala  Gly Ala Pro 
    1250                 1255                 1260             


Thr Val  Pro Ala Ala Val Glu  Val Trp Ala Gly Asn  Arg Phe Phe 
    1265                 1270                 1275             


Ala Arg  Gly Pro Ser Pro Ser  Leu Val Gly Lys Gly  Phe Thr Phe 
    1280                 1285                 1290             


Met Tyr  Glu Ala Ala Ala Thr  Pro Val Val Thr Ala  Met Gln Gly 
    1295                 1300                 1305             


Glu Ile  Thr Asn Ser Ser Leu  Ser Leu His Val Gly  Gly Ser Asn 
    1310                 1315                 1320             


Leu Ser  Asn Ser Val Ile Leu  Leu Gly Asn Leu Asn  Cys Asp Val 
    1325                 1330                 1335             


Glu Thr  Gln Ser Phe Gln Gly  Asn Val Ser Leu Ser  Gly Cys Ser 
    1340                 1345                 1350             


Ile Pro  Leu His Ser Leu Glu  Ala Gly Ile Tyr Pro  Leu Gln Val 
    1355                 1360                 1365             


Arg Gln  Lys Gln Met Gly Phe  Ala Asn Met Ser Val  Val Leu Gln 
    1370                 1375                 1380             


Gln Phe  Ala Val Met Pro Arg  Ile Met Ala Ile Phe  Pro Ser Gln 
    1385                 1390                 1395             


Gly Ser  Ala Cys Gly Gly Thr  Ile Leu Thr Val Arg  Gly Leu Leu 
    1400                 1405                 1410             


Leu Asn  Ser Arg Arg Arg Ser  Val Arg Val Asp Leu  Ser Gly Pro 
    1415                 1420                 1425             


Phe Thr  Cys Val Ile Leu Ser  Leu Gly Asp His Thr  Ile Leu Cys 
    1430                 1435                 1440             


Gln Val  Ser Leu Glu Gly Asp  Pro Leu Pro Gly Ala  Ser Phe Ser 
    1445                 1450                 1455             


Leu Asn  Val Thr Val Leu Val  Asn Gly Leu Thr Ser  Glu Cys Gln 
    1460                 1465                 1470             


Gly Asn  Cys Thr Leu Phe Ile  Arg Glu Glu Ala Ser  Pro Val Met 
    1475                 1480                 1485             


Asp Ala  Leu Ser Thr Asn Thr  Ser Gly Ser Leu Thr  Thr Val Leu 
    1490                 1495                 1500             


Ile Arg  Gly Gln Arg Leu Ala  Thr Thr Ala Asp Glu  Pro Met Val 
    1505                 1510                 1515             


Phe Val  Asp Asp Gln Leu Pro  Cys Asn Val Thr Phe  Phe Asn Ala 
    1520                 1525                 1530             


Ser His  Val Val Cys Gln Thr  Arg Asp Leu Ala Pro  Gly Pro His 
    1535                 1540                 1545             


Tyr Leu  Ser Val Phe Tyr Thr  Arg Asn Gly Tyr Ala  Cys Ser Gly 
    1550                 1555                 1560             


Asn Val  Ser Arg His Phe Tyr  Ile Met Pro Gln Val  Phe His Tyr 
    1565                 1570                 1575             


Phe Pro  Lys Asn Phe Ser Leu  His Gly Gly Ser Leu  Leu Thr Ile 
    1580                 1585                 1590             


Glu Gly  Thr Gly Leu Arg Gly  Gln Asn Thr Thr Ser  Val Tyr Ile 
    1595                 1600                 1605             


Asp Gln  Gln Thr Cys Leu Thr  Val Asn Ile Gly Ala  Glu Leu Ile 
    1610                 1615                 1620             


Arg Cys  Ile Val Pro Thr Gly  Asn Gly Ser Val Ala  Leu Glu Ile 
    1625                 1630                 1635             


Glu Val  Asp Gly Leu Trp Tyr  His Ile Gly Val Ile  Gly Tyr Asn 
    1640                 1645                 1650             


Lys Ala  Phe Thr Pro Glu Leu  Ile Ser Ile Ser Gln  Ser Asp Asp 
    1655                 1660                 1665             


Ile Leu  Thr Phe Ala Val Ala  Gln Ile Ser Gly Ala  Ala Asn Ile 
    1670                 1675                 1680             


Asp Ile  Phe Ile Gly Met Ser  Pro Cys Val Gly Val  Ser Gly Asn 
    1685                 1690                 1695             


His Thr  Val Leu Gln Cys Val  Val Pro Ser Leu Pro  Ala Gly Glu 
    1700                 1705                 1710             


Tyr His  Val Arg Gly Tyr Asp  Cys Ile Arg Gly Trp  Ala Ser Ser 
    1715                 1720                 1725             


Ala Leu  Val Phe Thr Ser Arg  Val Ile Ile Thr Ala  Val Thr Glu 
    1730                 1735                 1740             


Asn Phe  Gly Cys Leu Gly Gly  Arg Leu Val His Val  Phe Gly Ala 
    1745                 1750                 1755             


Gly Phe  Ser Pro Gly Asn Val  Ser Ala Ala Val Cys  Gly Ala Pro 
    1760                 1765                 1770             


Cys Arg  Val Leu Ala Asn Ala  Thr Val Ser Ala Phe  Ser Cys Leu 
    1775                 1780                 1785             


Val Leu  Pro Leu Asp Val Ser  Leu Ala Phe Leu Cys  Gly Leu Lys 
    1790                 1795                 1800             


Arg Glu  Glu Asp Ser Cys Glu  Ala Ala Arg His Thr  Tyr Val Gln 
    1805                 1810                 1815             


Cys Asp  Leu Thr Val Ala Met  Ala Thr Glu Gln Leu  Leu Glu Ser 
    1820                 1825                 1830             


Trp Pro  Tyr Leu Tyr Ile Cys  Glu Glu Ser Ser Gln  Cys Leu Phe 
    1835                 1840                 1845             


Val Pro  Asp His Trp Ala Glu  Ser Met Phe Pro Ser  Phe Ser Gly 
    1850                 1855                 1860             


Leu Phe  Ile Ser Pro Lys Leu  Glu Arg Asp Glu Val  Leu Ile Tyr 
    1865                 1870                 1875             


Asn Ser  Ser Cys Asn Ile Thr  Met Glu Thr Glu Ala  Glu Met Glu 
    1880                 1885                 1890             


Cys Glu  Thr Pro Asn Gln Pro  Ile Thr Val Lys Ile  Thr Glu Ile 
    1895                 1900                 1905             


Arg Lys  Arg Trp Gly Gln Asn  Thr Gln Gly Asn Phe  Ser Leu Gln 
    1910                 1915                 1920             


Phe Cys  Arg Arg Trp Ser Arg  Thr His Ser Trp Phe  Pro Glu Arg 
    1925                 1930                 1935             


Leu Pro  Gln Asp Gly Asp Asn  Val Thr Val Glu Asn  Gly Gln Leu 
    1940                 1945                 1950             


Leu Leu  Leu Asp Thr Asn Thr  Ser Ile Leu Asn Leu  Leu His Ile 
    1955                 1960                 1965             


Lys Gly  Gly Lys Leu Ile Phe  Met Ala Pro Gly Pro  Ile Glu Leu 
    1970                 1975                 1980             


Arg Ala  His Ala Ile Leu Val  Ser Asp Gly Gly Glu  Leu Arg Ile 
    1985                 1990                 1995             


Gly Ser  Glu Asp Lys Pro Phe  Gln Gly Arg Ala Gln  Ile Thr Leu 
    2000                 2005                 2010             


Tyr Gly  Ser Ser Tyr Ser Thr  Pro Phe Phe Pro Tyr  Gly Val Lys 
    2015                 2020                 2025             


Phe Leu  Ala Val Arg Asn Gly  Thr Leu Ser Leu His  Gly Ser Leu 
    2030                 2035                 2040             


Pro Glu  Val Ile Val Thr Cys  Leu Arg Ala Thr Ala  His Ala Leu 
    2045                 2050                 2055             


Asp Thr  Val Leu Ala Leu Glu  Asp Ala Val Asp Trp  Asn Pro Gly 
    2060                 2065                 2070             


Asp Glu  Val Val Ile Ile Ser  Gly Thr Gly Val Lys  Gly Ala Lys 
    2075                 2080                 2085             


Pro Met  Glu Glu Ile Val Thr  Val Glu Thr Val Gln  Asp Thr Asp 
    2090                 2095                 2100             


Leu Tyr  Leu Lys Ser Pro Leu  Arg Tyr Ser His Asn  Phe Thr Glu 
    2105                 2110                 2115             


Asn Trp  Val Ala Gly Glu His  His Ile Leu Lys Ala  Thr Val Ala 
    2120                 2125                 2130             


Leu Leu  Ser Arg Ser Ile Thr  Ile Gln Gly Asn Leu  Thr Asn Glu 
    2135                 2140                 2145             


Arg Glu  Lys Leu Leu Val Ser  Cys Gln Glu Ala Asn  Ala Pro Glu 
    2150                 2155                 2160             


Gly Asn  Leu Gln His Cys Leu  Tyr Ser Met Ser Glu  Lys Met Leu 
    2165                 2170                 2175             


Gly Ser  Arg Asp Met Gly Ala  Arg Val Ile Val Gln  Ser Phe Pro 
    2180                 2185                 2190             


Glu Glu  Pro Ser Gln Val Gln  Leu Lys Gly Val Gln  Phe Gln Val 
    2195                 2200                 2205             


Leu Gly  Gln Ala Phe His Lys  His Leu Ser Ser Leu  Thr Leu Val 
    2210                 2215                 2220             


Gly Ala  Met Arg Glu Ser Phe  Ile Gln Gly Cys Thr  Val Arg Asn 
    2225                 2230                 2235             


Ser Phe  Ser Arg Gly Leu Ser  Met Cys Gly Thr Leu  Gly Leu Lys 
    2240                 2245                 2250             


Val Asp  Ser Asn Val Phe Tyr  Asn Ile Leu Gly His  Ala Leu Leu 
    2255                 2260                 2265             


Val Gly  Thr Cys Thr Glu Met  Arg Tyr Ile Ser Trp  Glu Ala Ile 
    2270                 2275                 2280             


His Gly  Arg Lys Asp Asp Trp  Ser Gly His Gly Asn  Ile Ile Arg 
    2285                 2290                 2295             


Asn Asn  Val Ile Ile Gln Val  Ser Gly Ala Glu Gly  Leu Ser Asn 
    2300                 2305                 2310             


Pro Glu  Met Leu Thr Pro Ser  Gly Ile Tyr Ile Cys  Ser Pro Thr 
    2315                 2320                 2325             


Asn Val  Ile Glu Gly Asn Arg  Val Cys Gly Ala Gly  Tyr Gly Tyr 
    2330                 2335                 2340             


Phe Phe  His Leu Met Thr Asn  Gln Thr Ser Gln Ala  Pro Leu Leu 
    2345                 2350                 2355             


Ser Phe  Thr Gln Asn Ile Ala  His Ser Cys Thr Arg  Tyr Gly Leu 
    2360                 2365                 2370             


Phe Val  Tyr Pro Lys Phe Gln  Pro Pro Trp Asp Asn  Val Thr Gly 
    2375                 2380                 2385             


Thr Thr  Leu Phe Gln Ser Phe  Thr Val Trp Glu Ser  Ala Gly Gly 
    2390                 2395                 2400             


Ala Gln  Ile Phe Arg Ser Ser  Asn Leu Arg Leu Lys  Asn Phe Lys 
    2405                 2410                 2415             


Val Tyr  Ser Cys Arg Asp Phe  Gly Ile Asp Val Leu  Glu Ser Asp 
    2420                 2425                 2430             


Ala Asn  Thr Ser Val Thr Asp  Ser Leu Leu Leu Gly  His Phe Ala 
    2435                 2440                 2445             


His Lys  Gly Ser Leu Cys Met  Ser Ser Gly Ile Lys  Thr Pro Lys 
    2450                 2455                 2460             


Arg Trp  Glu Leu Met Val Ser  Asn Thr Thr Phe Val  Asn Phe Asp 
    2465                 2470                 2475             


Leu Ile  Asn Cys Val Ala Ile  Arg Thr Cys Ser Asp  Cys Ser Gln 
    2480                 2485                 2490             


Gly Gln  Gly Gly Phe Thr Val  Lys Thr Ser Gln Leu  Lys Phe Thr 
    2495                 2500                 2505             


Asn Ser  Ser Asn Leu Val Ala  Phe Pro Phe Pro His  Ala Ala Ile 
    2510                 2515                 2520             


Leu Glu  Asp Leu Asp Gly Ser  Leu Ser Gly Lys Asn  Arg Ser His 
    2525                 2530                 2535             


Ile Leu  Ala Ser Met Glu Thr  Leu Ser Ala Ser Cys  Leu Val Asn 
    2540                 2545                 2550             


Ser Ser  Phe Gly Arg Val Val  His Gly Ser Ala Cys  Gly Gly Gly 
    2555                 2560                 2565             


Val Leu  Phe His Arg Met Ser  Ile Gly Leu Ala Asn  Thr Pro Glu 
    2570                 2575                 2580             


Val Ser  Tyr Asp Leu Thr Met  Thr Asp Ser Arg Asn  Lys Thr Thr 
    2585                 2590                 2595             


Thr Val  Asn Tyr Val Arg Asp  Thr Leu Ser Asn Pro  Arg Gly Trp 
    2600                 2605                 2610             


Met Ala  Leu Leu Leu Asp Gln  Glu Thr Tyr Ser Leu  Gln Ser Glu 
    2615                 2620                 2625             


Asn Leu  Trp Ile Asn Arg Ser  Leu Gln Tyr Ser Ala  Thr Phe Asp 
    2630                 2635                 2640             


Asn Phe  Ala Pro Gly Asn Tyr  Leu Leu Leu Val His  Thr Asp Leu 
    2645                 2650                 2655             


Pro Pro  Tyr Pro Asp Ile Leu  Leu Arg Cys Gly Ser  Arg Val Gly 
    2660                 2665                 2670             


Leu Ser  Phe Pro Phe Leu Pro  Ser Pro Gly Gln Asn  Gln Gly Cys 
    2675                 2680                 2685             


Asp Trp  Phe Phe Asn Ser Gln  Leu Arg Gln Leu Thr  Tyr Leu Val 
    2690                 2695                 2700             


Ser Gly  Glu Gly Gln Val Gln  Val Ile Leu Arg Val  Lys Glu Gly 
    2705                 2710                 2715             


Met Pro  Pro Thr Ile Ser Ala  Ser Thr Ser Ala Pro  Glu Ser Ala 
    2720                 2725                 2730             


Leu Lys  Trp Ser Leu Pro Glu  Thr Trp Gln Gly Val  Glu Glu Gly 
    2735                 2740                 2745             


Trp Gly  Gly Tyr Asn Asn Thr  Ile Pro Gly Pro Gly  Asp Asp Val 
    2750                 2755                 2760             


Leu Ile  Leu Pro Asn Arg Thr  Val Leu Val Asp Thr  Asp Leu Pro 
    2765                 2770                 2775             


Phe Phe  Lys Gly Leu Tyr Val  Met Gly Thr Leu Asp  Phe Pro Val 
    2780                 2785                 2790             


Asp Arg  Ser Asn Val Leu Ser  Val Ala Cys Met Val  Ile Ala Gly 
    2795                 2800                 2805             


Gly Glu  Leu Lys Val Gly Thr  Leu Glu Asn Pro Leu  Glu Lys Glu 
    2810                 2815                 2820             


Gln Lys  Leu Leu Ile Leu Leu  Arg Ala Ser Glu Gly  Val Phe Cys 
    2825                 2830                 2835             


Asp Arg  Met Asn Gly Ile His  Ile Asp Pro Gly Thr  Ile Gly Val 
    2840                 2845                 2850             


Tyr Gly  Lys Val His Leu Tyr  Ser Ala Tyr Pro Lys  Asn Ser Trp 
    2855                 2860                 2865             


Thr His  Leu Gly Ala Asp Ile  Ala Ser Gly Asn Glu  Arg Ile Ile 
    2870                 2875                 2880             


Val Glu  Asp Ala Val Asp Trp  Arg Pro His Asp Lys  Ile Val Leu 
    2885                 2890                 2895             


Ser Ser  Ser Ser Tyr Glu Pro  His Glu Ala Glu Val  Leu Thr Val 
    2900                 2905                 2910             


Lys Glu  Val Lys Gly His His  Val Arg Ile Tyr Glu  Arg Leu Lys 
    2915                 2920                 2925             


His Arg  His Ile Gly Ser Val  His Val Thr Glu Asp  Gly Arg His 
    2930                 2935                 2940             


Ile Arg  Leu Ala Ala Glu Val  Gly Leu Leu Thr Arg  Asn Ile Gln 
    2945                 2950                 2955             


Ile Gln  Pro Asp Val Ser Cys  Arg Gly Arg Leu Phe  Val Gly Ser 
    2960                 2965                 2970             


Phe Arg  Lys Ser Ser Arg Glu  Glu Phe Ser Gly Val  Leu Gln Leu 
    2975                 2980                 2985             


Leu Asn  Val Glu Ile Gln Asn  Phe Gly Ser Pro Leu  Tyr Ser Ser 
    2990                 2995                 3000             


Val Glu  Phe Ser Asn Val Ser  Ala Gly Ser Trp Ile  Ile Ser Ser 
    3005                 3010                 3015             


Thr Leu  His Gln Ser Cys Gly  Gly Gly Ile His Ala  Ala Ala Ser 
    3020                 3025                 3030             


His Gly  Val Leu Leu Asn Asp  Asn Ile Val Phe Gly  Thr Ala Gly 
    3035                 3040                 3045             


His Gly  Ile Asp Leu Glu Gly  Gln Ala Tyr Thr Val  Thr Asn Asn 
    3050                 3055                 3060             


Leu Val  Val Leu Met Thr Gln  Pro Ala Trp Ser Thr  Ile Trp Val 
    3065                 3070                 3075             


Ala Gly  Ile Lys Val Asn Gln  Val Lys Asp Ile Asn  Leu His Gly 
    3080                 3085                 3090             


Asn Val  Val Ala Gly Ser Glu  Arg Leu Gly Phe His  Ile Arg Gly 
    3095                 3100                 3105             


His Lys  Cys Ser Ser Cys Glu  Leu Leu Trp Ser Asp  Asn Val Ala 
    3110                 3115                 3120             


His Ser  Ser Leu His Gly Leu  His Leu Tyr Lys Glu  Ser Gly Leu 
    3125                 3130                 3135             


Asp Asn  Cys Thr Arg Ile Ser  Gly Phe Leu Ala Phe  Lys Asn Phe 
    3140                 3145                 3150             


Asp Tyr  Gly Ala Met Leu His  Val Glu Asn Ser Val  Glu Ile Glu 
    3155                 3160                 3165             


Asn Ile  Thr Leu Val Asp Asn  Thr Ile Gly Leu Leu  Ala Val Val 
    3170                 3175                 3180             


Tyr Val  Phe Ser Ala Pro Gln  Asn Ser Val Lys Lys  Val Gln Ile 
    3185                 3190                 3195             


Val Leu  Arg Asn Ser Val Ile  Val Ala Thr Ser Ser  Ser Phe Asp 
    3200                 3205                 3210             


Cys Ile  Gln Asp Lys Val Lys  Pro His Ser Ala Asn  Leu Thr Ser 
    3215                 3220                 3225             


Thr Asp  Arg Ala Pro Ser Asn  Pro Arg Gly Gly Arg  Ile Gly Ile 
    3230                 3235                 3240             


Leu Trp  Pro Val Phe Thr Ser  Glu Pro Asn Gln Trp  Pro Gln Glu 
    3245                 3250                 3255             


Pro Trp  His Lys Val Arg Asn  Asp His Ser Ile Ser  Gly Ile Met 
    3260                 3265                 3270             


Lys Leu  Gln Asp Val Thr Phe  Ser Ser Phe Val Lys  Ser Cys Tyr 
    3275                 3280                 3285             


Ser Asp  Asp Leu Asp Val Cys  Ile Leu Pro Asn Ala  Glu Asn Ser 
    3290                 3295                 3300             


Gly Ile  Met His Pro Ile Thr  Ala Glu Arg Thr Arg  Met Leu Lys 
    3305                 3310                 3315             


Ile Lys  Asp Lys Asn Lys Phe  Tyr Phe Pro Ser Leu  Gln Pro Arg 
    3320                 3325                 3330             


Lys Asp  Leu Gly Lys Val Val  Cys Pro Glu Leu Asp  Cys Ala Ser 
    3335                 3340                 3345             


Pro Arg  Lys Tyr Leu Phe Lys  Asp Leu Asp Gly Arg  Ala Leu Gly 
    3350                 3355                 3360             


Leu Pro  Pro Pro Val Ser Val  Phe Pro Lys Thr Glu  Ala Glu Trp 
    3365                 3370                 3375             


Thr Ala  Ser Phe Phe Asn Ala  Gly Thr Phe Arg Glu  Glu Gln Lys 
    3380                 3385                 3390             


Cys Thr  Tyr Gln Phe Leu Met  Gln Gly Phe Ile Cys  Lys Gln Thr 
    3395                 3400                 3405             


Asp Gln  Val Val Leu Ile Leu  Asp Ser Ala Asp Ala  Ile Trp Ala 
    3410                 3415                 3420             


Ile Gln  Lys Leu Tyr Pro Val  Val Ser Val Thr Ser  Gly Phe Val 
    3425                 3430                 3435             


Asp Val  Phe Ser Ser Val Asn  Ala Asn Ile Pro Cys  Ser Thr Ser 
    3440                 3445                 3450             


Gly Ser  Val Ser Thr Phe Tyr  Ser Ile Leu Pro Ile  Arg Gln Ile 
    3455                 3460                 3465             


Thr Lys  Val Cys Phe Met Asp  Gln Thr Pro Gln Val  Leu Arg Phe 
    3470                 3475                 3480             


Phe Leu  Leu Gly Asn Lys Ser  Thr Ser Lys Leu Leu  Leu Ala Val 
    3485                 3490                 3495             


Phe Tyr  His Glu Leu Gln Ser  Pro His Val Phe Leu  Gly Glu Ser 
    3500                 3505                 3510             


Phe Ile  Pro Pro Thr Leu Val  Gln Ser Ala Ser Leu  Leu Leu Asn 
    3515                 3520                 3525             


Glu Ser  Ile Gly Ala Asn Tyr  Phe Asn Ile Met Asp  Asn Leu Leu 
    3530                 3535                 3540             


Tyr Val  Val Leu Gln Gly Glu  Glu Pro Ile Glu Ile  Arg Ser Gly 
    3545                 3550                 3555             


Val Ser  Ile His Leu Ala Leu  Thr Val Met Val Ser  Val Leu Glu 
    3560                 3565                 3570             


Lys Gly  Trp Glu Ile Val Ile  Leu Glu Arg Leu Thr  Asn Phe Leu 
    3575                 3580                 3585             


Gln Ile  Gly Gln Asn Gln Ile  Arg Phe Ile His Glu  Met Pro Gly 
    3590                 3595                 3600             


His Glu  Glu Thr Leu Lys Ala  Ile Ala Asp Ser Arg  Ala Lys Arg 
    3605                 3610                 3615             


Lys Arg  Asn Cys Pro Thr Val  Thr Cys Thr Ser His  Tyr Arg Arg 
    3620                 3625                 3630             


Val Gly  Gln Arg Arg Pro Leu  Met Met Glu Met Asn  Ser His Arg 
    3635                 3640                 3645             


Ala Ser  Pro Pro Met Thr Val  Glu Thr Ile Ser Lys  Val Ile Val 
    3650                 3655                 3660             


Ile Glu  Ile Gly Asp Ser Pro  Thr Val Arg Ser Thr  Gly Met Ile 
    3665                 3670                 3675             


Ser Ser  Leu Ser Ser Asn Lys  Leu Gln Asn Leu Ala  His Arg Val 
    3680                 3685                 3690             


Ile Thr  Ala Gln Gln Thr Gly  Val Leu Glu Asn Val  Leu Asn Met 
    3695                 3700                 3705             


Thr Ile  Gly Ala Leu Leu Val  Thr Gln Ser Lys Gly  Val Ile Gly 
    3710                 3715                 3720             


Tyr Gly  Asn Thr Ser Ser Phe  Lys Thr Gly Asn Leu  Ile Tyr Ile 
    3725                 3730                 3735             


Arg Pro  Tyr Ala Leu Ser Ile  Leu Val Gln Pro Ser  Asp Gly Glu 
    3740                 3745                 3750             


Val Gly  Asn Glu Leu Pro Val  Gln Pro Gln Leu Val  Phe Leu Asp 
    3755                 3760                 3765             


Glu Gln  Asn Arg Arg Val Glu  Ser Leu Gly Pro Pro  Ser Glu Pro 
    3770                 3775                 3780             


Trp Thr  Ile Ser Ala Ser Leu  Glu Gly Ala Ser Asp  Ser Val Leu 
    3785                 3790                 3795             


Lys Gly  Cys Thr Gln Ala Glu  Thr Gln Asp Gly Tyr  Val Ser Phe 
    3800                 3805                 3810             


Tyr Asn  Leu Ala Val Leu Ile  Ser Gly Ser Asn Trp  His Phe Ile 
    3815                 3820                 3825             


Phe Thr  Val Thr Ser Pro Pro  Gly Val Asn Phe Thr  Ala Arg Ser 
    3830                 3835                 3840             


Lys Pro  Phe Ala Val Leu Pro  Val Thr Arg Lys Glu  Lys Ser Thr 
    3845                 3850                 3855             


Ile Ile  Leu Ala Ala Ser Leu  Ser Ser Val Ala Ser  Trp Leu Ala 
    3860                 3865                 3870             


Leu Ser  Cys Leu Val Cys Cys  Trp Leu Lys Arg Ser  Lys Ser Arg 
    3875                 3880                 3885             


Lys Thr  Lys Pro Glu Glu Ile  Pro Glu Ser Gln Thr  Asn Asn Gln 
    3890                 3895                 3900             


Asn Ile  His Ile His Ile Ser  Ser Lys Arg Arg Glu  Ser Gln Gly 
    3905                 3910                 3915             


Pro Lys  Lys Glu Asp Thr Val  Val Gly Glu Asp Met  Arg Met Lys 
    3920                 3925                 3930             


Val Met  Leu Gly Lys Val Asn  Gln Cys Pro His Gln  Leu Met Asn 
    3935                 3940                 3945             


Gly Val  Ser Arg Arg Lys Val  Ser Arg His Ile Val  Arg Glu Glu 
    3950                 3955                 3960             


Glu Ala  Ala Val Pro Ala Pro  Gly Thr Thr Gly Ile  Thr Ser His 
    3965                 3970                 3975             


Gly His  Ile Cys Ala Pro Gly  Ala Pro Ala Gln Gln  Val Tyr Leu 
    3980                 3985                 3990             


Gln Glu  Thr Gly Asn Trp Lys  Glu Gly Gln Glu Gln  Leu Leu Arg 
    3995                 4000                 4005             


Tyr Gln  Leu Ala Gly Gln Asn  Gln Leu Leu Leu Leu  Cys Pro Asp 
    4010                 4015                 4020             


Phe Arg  Gln Glu Arg Gln Gln  Leu Pro Gly Gln Ser  Arg Leu Ser 
    4025                 4030                 4035             


Lys Gln  Ser Gly Ser Leu Gly  Leu Ser Gln Glu Lys  Lys Ala Ser 
    4040                 4045                 4050             


Cys Gly  Ala Thr Glu Ala Phe  Cys Leu His Ser Val  His Pro Glu 
    4055                 4060                 4065             


Thr Ile  Gln Glu Gln Leu 
    4070                 


<210>  165
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Ala Ser Arg Gly Arg Gly Trp 
            20                  25                  30          


Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro Ser 
        35                  40                  45              


Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys Asn 
    50                  55                  60                  


Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp Thr 
65                  70                  75                  80  


Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val Val 
                85                  90                  95      


Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly Phe 
            100                 105                 110         


Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu Asp 
        115                 120                 125             


Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys Ala 
    130                 135                 140                 


Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly Leu 
145                 150                 155                 160 


Asn Pro Glu Ser Pro Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr 
            260                 265                 270         


Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro 
        275                 280                 285             


Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly 
    290                 295                 300                 


Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln 
305                 310                 315                 320 


Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                325                 330         


<210>  166
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  167
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Pro Ser Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys 
1               5                   10                  15      


Lys Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile 
            20                  25                  30          


Lys Val Asn Gly Arg Pro Leu Glu Met Ile Glu Pro Arg Thr Leu Gln 
        35                  40                  45              


Tyr Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala 
    50                  55                  60                  


Gly Val Asp Ile Arg Val Arg Val Lys Gly Gly Gly His Val Ala Gln 
65                  70                  75                  80  


Ile Tyr Ala Ile Arg Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr 
                85                  90                  95      


Gln Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu 
            100                 105                 110         


Ile Gln Tyr Asp Arg Thr Leu Leu Val Ala Asp Pro Arg Arg Cys Glu 
        115                 120                 125             


Ser Lys Lys Phe Gly Gly Pro Gly Ala Arg Ala Arg Tyr Gln Lys Ser 
    130                 135                 140                 


Tyr Arg 
145     


<210>  168
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  169
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Pro Pro Lys Asp Asp Lys Lys Lys Lys Asp Ala Gly Lys Ser Ala 
1               5                   10                  15      


Lys Lys Asp Lys Asp Pro Val Asn Lys Ser Gly Gly Lys Ala Lys Lys 
            20                  25                  30          


Lys Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn Asn Leu Val 
        35                  40                  45              


Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro Asn 
    50                  55                  60                  


Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys Ile Arg 
65                  70                  75                  80  


Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser Lys Gly Leu 
                85                  90                  95      


Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr Thr Arg Asn 
            100                 105                 110         


Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala 
        115                 120                 125 


<210>  170
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg 
        115                 120                 125             


Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys 
    130                 135                 140                 


Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr 
145                 150                 155                 160 


Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala 
                165                 170                 175     


Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val 
            180                 185                 190         


Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu 
        195                 200                 205             


Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys 
    210                 215                 220                 


Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser 
225                 230                 235                 240 


Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe 
                245                 250                 255     


Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn 
            260                 265                 270         


Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn 
        275                 280                 285             


Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val 
    290                 295                 300                 


Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro 
305                 310                 315                 320 


Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly 
                325                 330                 335     


Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys 
            340                 345                 350         


Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys 
        355                 360                 365             


Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
    370                 375                 380         


<210>  171
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  172
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210>  173
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  174
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Asp Arg Val Thr Arg Tyr Pro Ile Leu Gly Ile Pro Gln Ala His 
1               5                   10                  15      


Arg Gly Thr Gly Leu Val Leu Asp Gly Asp Thr Ser Tyr Thr Tyr His 
            20                  25                  30          


Leu Val Cys Met Gly Pro Glu Ala Ser Gly Trp Gly Gln Asp Glu Pro 
        35                  40                  45              


Gln Thr Trp Pro Thr Asp His Arg Ala Gln Gln Gly Val Gln Arg Gln 
    50                  55                  60                  


Gly Val Ser Tyr Ser Val His Ala Tyr Thr Gly Gln Pro Ser Pro Arg 
65                  70                  75                  80  


Gly Leu His Ser Glu Asn Arg Glu Asp Glu Gly Trp Gln Val Tyr Arg 
                85                  90                  95      


Leu Gly Ala Arg Asp Ala His Gln Gly Arg Pro Thr Trp Ala Leu Arg 
            100                 105                 110         


Pro Glu Asp Gly Glu Asp Lys Glu Met Lys Thr Tyr Arg Leu Asp Ala 
        115                 120                 125             


Gly Asp Ala Asp Pro Arg Arg Leu Cys Asp Leu Glu Arg Glu Arg Trp 
    130                 135                 140                 


Ala Val Ile Gln Gly Gln Ala Val Arg Lys Ser Ser Thr Val Ala Thr 
145                 150                 155                 160 


Leu Gln Gly Thr Pro Asp His Gly Asp Pro Arg Thr Pro Gly Pro Pro 
                165                 170                 175     


Arg Ser Thr Pro Leu Glu Glu Asn Val Val Asp Arg Glu Gln Ile Asp 
            180                 185                 190         


Phe Leu Ala Ala Arg Gln Gln Phe Leu Ser Leu Glu Gln Ala Asn Lys 
        195                 200                 205             


Gly Ala Pro His Ser Ser Pro Ala Arg Gly Thr Pro Ala Gly Thr Thr 
    210                 215                 220                 


Pro Gly Ala Ser Gln Ala Pro Lys Ala Phe Asn Lys Pro His Leu Ala 
225                 230                 235                 240 


Asn Gly His Val Val Pro Ile Lys Pro Gln Val Lys Gly Val Val Arg 
                245                 250                 255     


Glu Glu Asn Lys Val Arg Ala Val Pro Thr Trp Ala Ser Val Gln Val 
            260                 265                 270         


Val Asp Asp Pro Gly Ser Leu Ala Ser Val Glu Ser Pro Gly Thr Pro 
        275                 280                 285             


Lys Glu Thr Pro Ile Glu Arg Glu Ile Arg Leu Ala Gln Glu Arg Glu 
    290                 295                 300                 


Ala Asp Leu Arg Glu Gln Arg Gly Leu Arg Gln Ala Thr Asp His Gln 
305                 310                 315                 320 


Glu Leu Val Glu Ile Pro Thr Arg Pro Leu Leu Thr Lys Leu Ser Leu 
                325                 330                 335     


Ile Thr Ala Pro Arg Arg Glu Arg Gly Arg Pro Ser Leu Tyr Val Gln 
            340                 345                 350         


Arg Asp Ile Val Gln Glu Thr Gln Arg Glu Glu Asp His Arg Arg Glu 
        355                 360                 365             


Gly Leu His Val Gly Arg Ala Ser Thr Pro Asp Trp Val Ser Glu Gly 
    370                 375                 380                 


Pro Gln Pro Gly Leu Arg Arg Ala Leu Ser Ser Asp Ser Ile Leu Ser 
385                 390                 395                 400 


Pro Ala Pro Asp Ala Arg Ala Ala Asp Pro Ala Pro Glu Val Arg Lys 
                405                 410                 415     


Val Asn Arg Ile Pro Pro Asp Ala Tyr Gln Pro Tyr Leu Ser Pro Gly 
            420                 425                 430         


Thr Pro Gln Leu Glu Phe Ser Ala Phe Gly Ala Phe Gly Lys Pro Ser 
        435                 440                 445             


Ser Leu Ser Thr Ala Glu Ala Lys Ala Ala Thr Ser Pro Lys Ala Thr 
    450                 455                 460                 


Met Ser Pro Arg His Leu Ser Glu Ser Ser Gly Lys Pro Leu Ser Thr 
465                 470                 475                 480 


Lys Gln Glu Ala Ser Lys Pro Pro Arg Gly Cys Pro Gln Ala Asn Arg 
                485                 490                 495     


Gly Val Val Arg Trp Glu Tyr Phe Arg Leu Arg Pro Leu Arg Phe Arg 
            500                 505                 510         


Ala Pro Asp Glu Pro Gln Gln Ala Gln Val Pro His Val Trp Gly Trp 
        515                 520                 525             


Glu Val Ala Gly Ala Pro Ala Leu Arg Leu Gln Lys Ser Gln Ser Ser 
    530                 535                 540                 


Asp Leu Leu Glu Arg Glu Arg Glu Ser Val Leu Arg Arg Glu Gln Glu 
545                 550                 555                 560 


Val Ala Glu Glu Arg Arg Asn Ala Leu Phe Pro Glu Val Phe Ser Pro 
                565                 570                 575     


Thr Pro Asp Glu Asn Ser Asp Gln Asn Ser Arg Ser Ser Ser Gln Ala 
            580                 585                 590         


Ser Gly Ile Thr Gly Ser Tyr Ser Val Ser Glu Ser Pro Phe Phe Ser 
        595                 600                 605             


Pro Ile His Leu His Ser Asn Val Ala Trp Thr Val Glu Asp Pro Val 
    610                 615                 620                 


Asp Ser Ala Pro Pro Gly Gln Arg Lys Lys Glu Gln Trp Tyr Ala Gly 
625                 630                 635                 640 


Ile Asn Pro Ser Asp Gly Ile Asn Ser Glu Val Leu Glu Ala Ile Arg 
                645                 650                 655     


Val Thr Arg His Lys Asn Ala Met Ala Glu Arg Trp Glu Ser Arg Ile 
            660                 665                 670         


Tyr Ala Ser Glu Glu Asp Asp 
        675                 


<210>  175
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ser Asp Ser Gly Ser Tyr Gly Gln Ser Gly Gly Glu Gln Gln Ser 
1               5                   10                  15      


Tyr Ser Thr Tyr Gly Asn Pro Gly Ser Gln Gly Tyr Gly Gln Ala Ser 
            20                  25                  30          


Gln Ser Tyr Ser Gly Tyr Gly Gln Thr Thr Asp Ser Ser Tyr Gly Gln 
        35                  40                  45              


Asn Tyr Ser Gly Tyr Ser Ser Tyr Gly Gln Ser Gln Ser Gly Tyr Ser 
    50                  55                  60                  


Gln Ser Tyr Gly Gly Tyr Glu Asn Gln Lys Gln Ser Ser Tyr Ser Gln 
65                  70                  75                  80  


Gln Pro Tyr Asn Asn Gln Gly Gln Gln Gln Asn Met Glu Ser Ser Gly 
                85                  90                  95      


Ser Gln Gly Gly Arg Ala Pro Ser Tyr Asp Gln Pro Asp Tyr Gly Gln 
            100                 105                 110         


Gln Asp Ser Tyr Asp Gln Gln Ser Gly Tyr Asp Gln His Gln Gly Ser 
        115                 120                 125             


Tyr Asp Glu Gln Ser Asn Tyr Asp Gln Gln His Asp Ser Tyr Ser Gln 
    130                 135                 140                 


Asn Gln Gln Ser Tyr His Ser Gln Arg Glu Asn Tyr Ser His His Thr 
145                 150                 155                 160 


Gln Asp Asp Arg Arg Asp Val Ser Arg Tyr Gly Glu Asp Asn Arg Gly 
                165                 170                 175     


Tyr Gly Gly Ser Gln Gly Gly Gly Arg Gly Arg Gly Gly Tyr Asp Lys 
            180                 185                 190         


Asp Gly Arg Gly Pro Met Thr Gly Ser Ser Gly Gly Asp Arg Gly Gly 
        195                 200                 205             


Phe Lys Asn Phe Gly Gly His Arg Asp Tyr Gly Pro Arg Thr Asp Ala 
    210                 215                 220                 


Asp Ser Glu Ser Asp Asn Ser Asp Asn Asn Thr Ile Phe Val Gln Gly 
225                 230                 235                 240 


Leu Gly Glu Gly Val Ser Thr Asp Gln Val Gly Glu Phe Phe Lys Gln 
                245                 250                 255     


Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Lys Pro Met Ile Asn 
            260                 265                 270         


Leu Tyr Thr Asp Lys Asp Thr Gly Lys Pro Lys Gly Glu Ala Thr Val 
        275                 280                 285             


Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp Phe Asp 
    290                 295                 300                 


Gly Lys Glu Phe His Gly Asn Ile Ile Lys Val Ser Phe Ala Thr Arg 
305                 310                 315                 320 


Arg Pro Glu Phe Met Arg Gly Gly Gly Ser Gly Gly Gly Arg Arg Gly 
                325                 330                 335     


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Phe Gln Gly Arg Gly Gly Asp 
            340                 345                 350         


Pro Lys Ser Gly Asp Trp Val Cys Pro Asn Pro Ser Cys Gly Asn Met 
        355                 360                 365             


Asn Phe Ala Arg Arg Asn Ser Cys Asn Gln Cys Asn Glu Pro Arg Pro 
    370                 375                 380                 


Glu Asp Ser Arg Pro Ser Gly Gly Asp Phe Arg Gly Arg Gly Tyr Gly 
385                 390                 395                 400 


Gly Glu Arg Gly Tyr Arg Gly Arg Gly Gly Arg Gly Gly Asp Arg Gly 
                405                 410                 415     


Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Ser 
            420                 425                 430         


Ser Gly Gly Gly Tyr Ser Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly 
        435                 440                 445             


Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly 
    450                 455                 460                 


Gly Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly 
465                 470                 475                 480 


Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly Gly 
                485                 490                 495     


Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg 
            500                 505                 510         


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Ser Arg 
        515                 520                 525             


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Ser Gly Tyr Gly Gly Asp 
    530                 535                 540                 


Arg Ser Gly Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly 
545                 550                 555                 560 


Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Lys 
                565                 570                 575     


Met Gly Gly Arg Asn Asp Tyr Arg Asn Asp Gln Arg Asn Arg Pro Tyr 
            580                 585                 590         


<210>  176
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu Cys Met Asp Val 
1               5                   10                  15      


Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu 
            20                  25                  30          


Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala 
        35                  40                  45              


Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr 
    50                  55                  60                  


Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His 
65                  70                  75                  80  


Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser 
                85                  90                  95      


Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile 
            100                 105                 110         


Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu 
        115                 120                 125             


Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys 
    130                 135                 140                 


Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser 
145                 150                 155                 160 


Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu Asp Gly Ser Gly 
                165                 170                 175     


Asp Arg Gly Asp Gly Pro Phe Arg Leu Gly Gly His Gly Pro Ser Phe 
            180                 185                 190         


Pro Leu Lys Gly Ile Thr Glu Gln Gln Lys Glu Gly Leu Glu Ile Val 
        195                 200                 205             


Lys Met Val Met Ile Ser Leu Glu Gly Glu Asp Gly Leu Asp Glu Ile 
    210                 215                 220                 


Tyr Ser Phe Ser Glu Ser Leu Arg Lys Leu Cys Val Phe Lys Lys Ile 
225                 230                 235                 240 


Glu Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn 
                245                 250                 255     


Leu Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val 
            260                 265                 270         


Lys Lys Thr Trp Thr Val Val Asp Ala Lys Thr Leu Lys Lys Glu Asp 
        275                 280                 285             


Ile Gln Lys Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu 
    290                 295                 300                 


Val Leu Lys Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile 
305                 310                 315                 320 


Val Pro Phe Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu 
                325                 330                 335     


Gly Lys Cys Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln 
            340                 345                 350         


Arg Arg Phe Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg 
        355                 360                 365             


Asp Asp Glu Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu 
    370                 375                 380                 


Asp Asp Leu Asp Met Val Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg 
385                 390                 395                 400 


Ala Asn Pro Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr 
                405                 410                 415     


Glu Cys Leu Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln 
            420                 425                 430         


Tyr Met Phe Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu 
        435                 440                 445             


Ala Gln Leu Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala 
    450                 455                 460                 


Lys Lys Asp Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr 
465                 470                 475                 480 


Lys Ile Pro Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His 
                485                 490                 495     


Arg Ala Leu His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile 
            500                 505                 510         


Trp Asn Met Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile 
        515                 520                 525             


Pro Leu Ser Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys 
    530                 535                 540                 


Lys Asp Gln Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp 
545                 550                 555                 560 


Gly Pro Thr Ala Lys Lys Leu Lys Thr Glu Gln Gly Gly Ala His Phe 
                565                 570                 575     


Ser Val Ser Ser Leu Ala Glu Gly Ser Val Thr Ser Val Gly Ser Val 
            580                 585                 590         


Asn Pro Ala Glu Asn Phe Arg Val Leu Val Lys Gln Lys Lys Ala Ser 
        595                 600                 605             


Phe Glu Glu Ala Ser Asn Gln Leu Ile Asn His Ile Glu Gln Phe Leu 
    610                 615                 620                 


Asp Thr Asn Glu Thr Pro Tyr Phe Met Lys Ser Ile Asp Cys Ile Arg 
625                 630                 635                 640 


Ala Phe Arg Glu Glu Ala Ile Lys Phe Ser Glu Glu Gln Arg Phe Asn 
                645                 650                 655     


Asn Phe Leu Lys Ala Leu Gln Glu Lys Val Glu Ile Lys Gln Leu Asn 
            660                 665                 670         


His Phe Trp Glu Ile Val Val Gln Asp Gly Ile Thr Leu Ile Thr Lys 
        675                 680                 685             


Glu Glu Ala Ser Gly Ser Ser Val Thr Ala Glu Glu Ala Lys Lys Phe 
    690                 695                 700                 


Leu Ala Pro Lys Asp Lys Pro Ser Gly Asp Thr Ala Ala Val Phe Glu 
705                 710                 715                 720 


Glu Gly Gly Asp Val Asp Asp Leu Leu Asp Met Ile 
                725                 730         


<210>  177
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Val Pro Leu Val Ala Val Val Ser Gly Pro Arg Ala Gln Leu Phe 
1               5                   10                  15      


Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu 
            20                  25                  30          


His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr Glu Val Leu Val 
        35                  40                  45              


Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys Arg 
    50                  55                  60                  


Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro Ser Glu Arg His 
65                  70                  75                  80  


Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly Ala Lys Gln Leu 
                85                  90                  95      


Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu 
            100                 105                 110         


Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile 
        115                 120                 125             


His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile Ile Ala 
    130                 135                 140                 


Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly 
145                 150                 155                 160 


Phe Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val Lys Thr Val Glu 
                165                 170                 175     


Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe 
            180                 185                 190         


Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile 
        195                 200                 205             


Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly Lys Arg Ser Lys 
    210                 215                 220                 


Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys 
225                 230                 235                 240 


Lys Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu Arg Asn Leu Thr 
                245                 250                 255     


Val Asn Tyr Lys Lys Asn Leu Ile Glu Val Arg Ala Asp Lys Gln Glu 
            260                 265                 270         


Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser 
        275                 280                 285             


Tyr Glu Met Leu His Val Thr Pro Pro Met Ser Pro Pro Asp Val Leu 
    290                 295                 300                 


Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys 
305                 310                 315                 320 


Glu Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp 
                325                 330                 335     


Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala Ala Ala Val Ala Ala Gln 
            340                 345                 350         


Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr 
        355                 360                 365             


Pro Thr Lys Lys Tyr Asp Gly Tyr Thr Ser Cys Pro Leu Val Thr Gly 
    370                 375                 380                 


Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro Leu 
385                 390                 395                 400 


Glu Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu 
                405                 410                 415     


Met Lys Ala Asp Leu Met Pro Phe Leu Tyr Trp Asn Met Met Leu Arg 
            420                 425                 430         


Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His Leu Gly 
        435                 440                 445             


Met Ser 
    450 


<210>  178
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu 
    130                 135                 140                 


Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn 
145                 150                 155                 160 


Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu 
                165                 170                 175     


Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His 
            180                 185                 190         


Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala 
        195                 200                 205             


Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile 
    210                 215                 220                 


Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu 
225                 230                 235                 240 


Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn 
                245                 250                 255     


Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu 
            260                 265                 270         


Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr 
        275                 280                 285             


Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu 
    290                 295                 300                 


Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile 
305                 310                 315                 320 


Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala 
                325                 330                 335     


Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr 
            340                 345                 350         


Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu 
        355                 360                 365             


Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu 
    370                 375                 380                 


Ser Met Glu Thr Gln Glu 
385                 390 


<210>  179
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Val Thr Met Ala Asn Ile 
            260                 265                 270         


Gly Ile Asn Gly Asn His Ser Leu Glu Thr Cys Glu Thr Thr Leu Phe 
        275                 280                 285             


Ala Leu Arg Met Ala Thr Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr 
    290                 295                 300                 


Ile Leu Leu Arg Lys Ala Val Leu Lys Asn Leu Tyr Lys Leu Ala Ser 
305                 310                 315                 320 


Gln Cys Cys Gly Val His Val Ile Ser Leu His Ile Trp Glu Leu Ser 
                325                 330                 335     


Ser Ile Lys Asn Ser Leu Lys Val Ala Ala Ile Ser Glu Ser Pro Val 
            340                 345                 350         


Ala Glu Lys Ser Ala Ser Thr 
        355                 


<210>  180
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  180

Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu 
            20                  25                  30          


Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser 
        35                  40                  45              


Pro Thr Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala 
    50                  55                  60                  


Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys 
65                  70                  75                  80  


Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly 
                85                  90                  95      


Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His 
            100                 105                 110         


Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His 
        115                 120                 125             


Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser 
    130                 135                 140                 


His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu 
145                 150                 155                 160 


Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro 
                165                 170                 175     


Tyr Gln Glu Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys 
            180                 185                 190         


Lys Asn Ser Leu Cys Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp 
        195                 200                 205             


Leu Pro Tyr Leu Val Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala 
    210                 215                 220                 


Ser Asp Ser Arg Lys Met Gly Thr Pro Ser Ser Leu Ala Thr Gly Ile 
225                 230                 235                 240 


Pro Ala Phe Leu Val Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala 
                245                 250                 255     


Leu Pro Ala Val Glu Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp 
            260                 265                 270         


Pro Pro Ser Met Ala Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Val 
        275                 280                 285             


Pro Ser Ile Leu Ala Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro 
    290                 295                 300                 


Val Thr Phe Pro Lys Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp 
305                 310                 315                 320 


Lys Val Thr Asp Lys Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser 
                325                 330                 335     


Leu Asp Pro Lys Met Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His 
            340                 345                 350         


Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu 
        355                 360                 365             


Val Leu Ala Ser Val Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln 
    370                 375                 380                 


Ala Thr Leu Asp His Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn 
385                 390                 395                 400 


Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu 
                405                 410                 415     


Ala Leu Gln Ser Ser Leu Pro Gly Ala Glu Gly Pro Asp Lys Pro Ser 
            420                 425                 430         


Val Val Ser Gly Leu Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu 
        435                 440                 445             


Leu Gly Leu Leu Leu Leu Pro Pro Leu Val Leu Ala Gly Ile Phe 
    450                 455                 460             


<210>  181
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  182
<211>  3224
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu 
            260                 265                 270         


Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His 
        275                 280                 285             


Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser 
    290                 295                 300                 


Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr 
305                 310                 315                 320 


Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly 
                325                 330                 335     


Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser 
            340                 345                 350         


Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe 
        355                 360                 365             


Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala 
    370                 375                 380                 


Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe 
385                 390                 395                 400 


Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu 
                405                 410                 415     


Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly 
            420                 425                 430         


Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro 
        435                 440                 445             


Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu 
    450                 455                 460                 


Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys 
465                 470                 475                 480 


Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His 
                485                 490                 495     


Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro 
            500                 505                 510         


Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln 
        515                 520                 525             


Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val 
    530                 535                 540                 


Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn 
545                 550                 555                 560 


Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val 
                565                 570                 575     


His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe 
            580                 585                 590         


Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys 
        595                 600                 605             


Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu 
    610                 615                 620                 


Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 
625                 630                 635                 640 


Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile 
                645                 650                 655     


Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 
            660                 665                 670         


Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 
        675                 680                 685             


Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 
    690                 695                 700                 


Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys 
705                 710                 715                 720 


Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 
                725                 730                 735     


Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu 
            740                 745                 750         


Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 
        755                 760                 765             


Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Arg 
    770                 775                 780                 


Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro 
785                 790                 795                 800 


Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln 
                805                 810                 815     


Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 
            820                 825                 830         


Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 
        835                 840                 845             


Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 
    850                 855                 860                 


Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 
865                 870                 875                 880 


Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 
                885                 890                 895     


Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln 
            900                 905                 910         


His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser 
        915                 920                 925             


Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu 
    930                 935                 940                 


Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp 
945                 950                 955                 960 


Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro 
                965                 970                 975     


Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg 
            980                 985                 990         


Ser Ala Glu Ser Lys Thr Ile Glu  Phe Gly Lys Thr Asn  Phe Val Gln 
        995                 1000                 1005             


Pro Met  Pro Gly Glu Gly Leu  Arg Pro Ser Leu Pro  Thr Gln Ala 
    1010                 1015                 1020             


His Thr  Thr Gln Pro Thr Pro  Phe Lys Phe Asn Ser  Asn Phe Lys 
    1025                 1030                 1035             


Ser Asn  Asp Gly Asp Phe Thr  Phe Ser Ser Pro Gln  Val Val Thr 
    1040                 1045                 1050             


Gln Pro  Pro Pro Ala Ala Tyr  Ser Asn Ser Glu Ser  Leu Leu Gly 
    1055                 1060                 1065             


Leu Leu  Thr Ser Asp Lys Pro  Leu Gln Gly Asp Gly  Tyr Ser Gly 
    1070                 1075                 1080             


Ala Lys  Pro Ile Pro Gly Gly  Gln Thr Ile Gly Pro  Arg Asn Thr 
    1085                 1090                 1095             


Phe Asn  Phe Gly Ser Lys Asn  Val Ser Gly Ile Ser  Phe Thr Glu 
    1100                 1105                 1110             


Asn Met  Gly Ser Ser Gln Gln  Lys Asn Ser Gly Phe  Arg Arg Ser 
    1115                 1120                 1125             


Asp Asp  Met Phe Thr Phe His  Gly Pro Gly Lys Ser  Val Phe Gly 
    1130                 1135                 1140             


Thr Pro  Thr Leu Glu Thr Ala  Asn Lys Asn His Glu  Thr Asp Gly 
    1145                 1150                 1155             


Gly Ser  Ala His Gly Asp Asp  Asp Asp Asp Gly Pro  His Phe Glu 
    1160                 1165                 1170             


Pro Val  Val Pro Leu Pro Asp  Lys Ile Glu Val Lys  Thr Gly Glu 
    1175                 1180                 1185             


Glu Asp  Glu Glu Glu Phe Phe  Cys Asn Arg Ala Lys  Leu Phe Arg 
    1190                 1195                 1200             


Phe Asp  Val Glu Ser Lys Glu  Trp Lys Glu Arg Gly  Ile Gly Asn 
    1205                 1210                 1215             


Val Lys  Ile Leu Arg His Lys  Thr Ser Gly Lys Ile  Arg Leu Leu 
    1220                 1225                 1230             


Met Arg  Arg Glu Gln Val Leu  Lys Ile Cys Ala Asn  His Tyr Ile 
    1235                 1240                 1245             


Ser Pro  Asp Met Lys Leu Thr  Pro Asn Ala Gly Ser  Asp Arg Ser 
    1250                 1255                 1260             


Phe Val  Trp His Ala Leu Asp  Tyr Ala Asp Glu Leu  Pro Lys Pro 
    1265                 1270                 1275             


Glu Gln  Leu Ala Ile Arg Phe  Lys Thr Pro Glu Glu  Ala Ala Leu 
    1280                 1285                 1290             


Phe Lys  Cys Lys Phe Glu Glu  Ala Gln Ser Ile Leu  Lys Ala Pro 
    1295                 1300                 1305             


Gly Thr  Asn Val Ala Met Ala  Ser Asn Gln Ala Val  Arg Ile Val 
    1310                 1315                 1320             


Lys Glu  Pro Thr Ser His Asp  Asn Lys Asp Ile Cys  Lys Ser Asp 
    1325                 1330                 1335             


Ala Gly  Asn Leu Asn Phe Glu  Phe Gln Val Ala Lys  Lys Glu Gly 
    1340                 1345                 1350             


Ser Trp  Trp His Cys Asn Ser  Cys Ser Leu Lys Asn  Ala Ser Thr 
    1355                 1360                 1365             


Ala Lys  Lys Cys Val Ser Cys  Gln Asn Leu Asn Pro  Ser Asn Lys 
    1370                 1375                 1380             


Glu Leu  Val Gly Pro Pro Leu  Ala Glu Thr Val Phe  Thr Pro Lys 
    1385                 1390                 1395             


Thr Ser  Pro Glu Asn Val Gln  Asp Arg Phe Ala Leu  Val Thr Pro 
    1400                 1405                 1410             


Lys Lys  Glu Gly His Trp Asp  Cys Ser Ile Cys Leu  Val Arg Asn 
    1415                 1420                 1425             


Glu Pro  Thr Val Ser Arg Cys  Ile Ala Cys Gln Asn  Thr Lys Ser 
    1430                 1435                 1440             


Ala Asn  Lys Ser Gly Ser Ser  Phe Val His Gln Ala  Ser Phe Lys 
    1445                 1450                 1455             


Phe Gly  Gln Gly Asp Leu Pro  Lys Pro Ile Asn Ser  Asp Phe Arg 
    1460                 1465                 1470             


Ser Val  Phe Ser Thr Lys Glu  Gly Gln Trp Asp Cys  Ser Ala Cys 
    1475                 1480                 1485             


Leu Val  Gln Asn Glu Gly Ser  Ser Thr Lys Cys Ala  Ala Cys Gln 
    1490                 1495                 1500             


Asn Pro  Arg Lys Gln Ser Leu  Pro Ala Thr Ser Ile  Pro Thr Pro 
    1505                 1510                 1515             


Ala Ser  Phe Lys Phe Gly Thr  Ser Glu Thr Ser Lys  Thr Leu Lys 
    1520                 1525                 1530             


Ser Gly  Phe Glu Asp Met Phe  Ala Lys Lys Glu Gly  Gln Trp Asp 
    1535                 1540                 1545             


Cys Ser  Ser Cys Leu Val Arg  Asn Glu Ala Asn Ala  Thr Arg Cys 
    1550                 1555                 1560             


Val Ala  Cys Gln Asn Pro Asp  Lys Pro Ser Pro Ser  Thr Ser Val 
    1565                 1570                 1575             


Pro Ala  Pro Ala Ser Phe Lys  Phe Gly Thr Ser Glu  Thr Ser Lys 
    1580                 1585                 1590             


Ala Pro  Lys Ser Gly Phe Glu  Gly Met Phe Thr Lys  Lys Glu Gly 
    1595                 1600                 1605             


Gln Trp  Asp Cys Ser Val Cys  Leu Val Arg Asn Glu  Ala Ser Ala 
    1610                 1615                 1620             


Thr Lys  Cys Ile Ala Cys Gln  Asn Pro Gly Lys Gln  Asn Gln Thr 
    1625                 1630                 1635             


Thr Ser  Ala Val Ser Thr Pro  Ala Ser Ser Glu Thr  Ser Lys Ala 
    1640                 1645                 1650             


Pro Lys  Ser Gly Phe Glu Gly  Met Phe Thr Lys Lys  Glu Gly Gln 
    1655                 1660                 1665             


Trp Asp  Cys Ser Val Cys Leu  Val Arg Asn Glu Ala  Ser Ala Thr 
    1670                 1675                 1680             


Lys Cys  Ile Ala Cys Gln Asn  Pro Gly Lys Gln Asn  Gln Thr Thr 
    1685                 1690                 1695             


Ser Ala  Val Ser Thr Pro Ala  Ser Ser Glu Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Lys Ser  Gly Phe Glu Gly Met  Phe Thr Lys Lys Glu  Gly Gln Trp 
    1715                 1720                 1725             


Asp Cys  Ser Val Cys Leu Val  Arg Asn Glu Ala Ser  Ala Thr Lys 
    1730                 1735                 1740             


Cys Ile  Ala Cys Gln Cys Pro  Ser Lys Gln Asn Gln  Thr Thr Ala 
    1745                 1750                 1755             


Ile Ser  Thr Pro Ala Ser Ser  Glu Ile Ser Lys Ala  Pro Lys Ser 
    1760                 1765                 1770             


Gly Phe  Glu Gly Met Phe Ile  Arg Lys Gly Gln Trp  Asp Cys Ser 
    1775                 1780                 1785             


Val Cys  Cys Val Gln Asn Glu  Ser Ser Ser Leu Lys  Cys Val Ala 
    1790                 1795                 1800             


Cys Asp  Ala Ser Lys Pro Thr  His Lys Pro Ile Ala  Glu Ala Pro 
    1805                 1810                 1815             


Ser Ala  Phe Thr Leu Gly Ser  Glu Met Lys Leu His  Asp Ser Ser 
    1820                 1825                 1830             


Gly Ser  Gln Val Gly Thr Gly  Phe Lys Ser Asn Phe  Ser Glu Lys 
    1835                 1840                 1845             


Ala Ser  Lys Phe Gly Asn Thr  Glu Gln Gly Phe Lys  Phe Gly His 
    1850                 1855                 1860             


Val Asp  Gln Glu Asn Ser Pro  Ser Phe Met Phe Gln  Gly Ser Ser 
    1865                 1870                 1875             


Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly Phe Ser  Ile Pro Val 
    1880                 1885                 1890             


Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser Glu Pro  Gly Asn Gln 
    1895                 1900                 1905             


Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn Gly Thr  Gly Phe Gln 
    1910                 1915                 1920             


Ala Gln  Asp Ile Ser Gly Gln  Lys Asn Gly Arg Gly  Val Ile Phe 
    1925                 1930                 1935             


Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala Asp Leu  Ala Lys Ser 
    1940                 1945                 1950             


Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys Lys Asp  Pro Asn Phe 
    1955                 1960                 1965             


Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
    1970                 1975                 1980             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1985                 1990                 1995             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    2000                 2005                 2010             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    2015                 2020                 2025             


Glu Glu  Asp Glu Lys Val Leu  Tyr Ser Gln Arg Val  Lys Leu Phe 
    2030                 2035                 2040             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    2045                 2050                 2055             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Leu Arg Met 
    2060                 2065                 2070             


Leu Met  Arg Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    2075                 2080                 2085             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    2090                 2095                 2100             


Ala Trp  Met Trp Leu Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    2105                 2110                 2115             


Leu Glu  Gln Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    2120                 2125                 2130             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    2135                 2140                 2145             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    2150                 2155                 2160             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    2165                 2170                 2175             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Thr Glu 
    2180                 2185                 2190             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    2195                 2200                 2205             


Thr Thr  Ile Lys Pro Asn Pro  Glu Asn Thr Gly Pro  Thr Leu Glu 
    2210                 2215                 2220             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    2225                 2230                 2235             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    2240                 2245                 2250             


Arg Lys  Asn Leu Phe Arg Phe  Gly Glu Ser Thr Thr  Gly Phe Asn 
    2255                 2260                 2265             


Phe Ser  Phe Lys Ser Ala Leu  Ser Pro Ser Lys Ser  Pro Ala Lys 
    2270                 2275                 2280             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    2285                 2290                 2295             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    2300                 2305                 2310             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    2315                 2320                 2325             


Glu Gln  Val Val Phe Ser His  Arg Ala Lys Leu Tyr  Arg Tyr Asp 
    2330                 2335                 2340             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    2345                 2350                 2355             


Ile Leu  Gln Asn Tyr Asp Asn  Lys Gln Val Arg Ile  Val Met Arg 
    2360                 2365                 2370             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    2375                 2380                 2385             


Asp Met  Thr Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Leu 
    2390                 2395                 2400             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    2405                 2410                 2415             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    2420                 2425                 2430             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    2435                 2440                 2445             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    2450                 2455                 2460             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    2465                 2470                 2475             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Thr Ser 
    2480                 2485                 2490             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Pro  Lys Ala Val 
    2495                 2500                 2505             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Ser 
    2510                 2515                 2520             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    2525                 2530                 2535             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    2540                 2545                 2550             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    2555                 2560                 2565             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    2570                 2575                 2580             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Phe Ala 
    2585                 2590                 2595             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    2600                 2605                 2610             


Pro Glu  Lys Ala Lys Glu Lys  Lys Lys Pro Glu Asp  Ser Pro Ser 
    2615                 2620                 2625             


Asp Asp  Asp Val Leu Ile Val  Tyr Glu Leu Thr Pro  Thr Ala Glu 
    2630                 2635                 2640             


Gln Lys  Ala Leu Ala Thr Lys  Leu Lys Leu Pro Pro  Thr Phe Phe 
    2645                 2650                 2655             


Cys Tyr  Lys Asn Arg Pro Asp  Tyr Val Ser Glu Glu  Glu Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Phe Glu Thr Ala  Val Lys Lys Leu Asn  Gly Lys Leu 
    2675                 2680                 2685             


Tyr Leu  Asp Gly Ser Glu Lys  Cys Arg Pro Leu Glu  Glu Asn Thr 
    2690                 2695                 2700             


Ala Asp  Asn Glu Lys Glu Cys  Ile Ile Val Trp Glu  Lys Lys Pro 
    2705                 2710                 2715             


Thr Val  Glu Glu Lys Ala Lys  Ala Asp Thr Leu Lys  Leu Pro Pro 
    2720                 2725                 2730             


Thr Phe  Phe Cys Gly Val Cys  Ser Asp Thr Asp Glu  Asp Asn Gly 
    2735                 2740                 2745             


Asn Gly  Glu Asp Phe Gln Ser  Glu Leu Gln Lys Val  Gln Glu Ala 
    2750                 2755                 2760             


Gln Lys  Ser Gln Thr Glu Glu  Ile Thr Ser Thr Thr  Asp Ser Val 
    2765                 2770                 2775             


Tyr Thr  Gly Gly Thr Glu Val  Met Val Pro Ser Phe  Cys Lys Ser 
    2780                 2785                 2790             


Glu Glu  Pro Asp Ser Ile Thr  Lys Ser Ile Ser Ser  Pro Ser Val 
    2795                 2800                 2805             


Ser Ser  Glu Thr Met Asp Lys  Pro Val Asp Leu Ser  Thr Arg Lys 
    2810                 2815                 2820             


Glu Ile  Asp Thr Asp Ser Thr  Ser Gln Gly Glu Ser  Lys Ile Val 
    2825                 2830                 2835             


Ser Phe  Gly Phe Gly Ser Ser  Thr Gly Leu Ser Phe  Ala Asp Leu 
    2840                 2845                 2850             


Ala Ser  Ser Asn Ser Gly Asp  Phe Ala Phe Gly Ser  Lys Asp Lys 
    2855                 2860                 2865             


Asn Phe  Gln Trp Ala Asn Thr  Gly Ala Ala Val Phe  Gly Thr Gln 
    2870                 2875                 2880             


Ser Val  Gly Thr Gln Ser Ala  Gly Lys Val Gly Glu  Asp Glu Asp 
    2885                 2890                 2895             


Gly Ser  Asp Glu Glu Val Val  His Asn Glu Asp Ile  His Phe Glu 
    2900                 2905                 2910             


Pro Ile  Val Ser Leu Pro Glu  Val Glu Val Lys Ser  Gly Glu Glu 
    2915                 2920                 2925             


Asp Glu  Glu Ile Leu Phe Lys  Glu Arg Ala Lys Leu  Tyr Arg Trp 
    2930                 2935                 2940             


Asp Arg  Asp Val Ser Gln Trp  Lys Glu Arg Gly Val  Gly Asp Ile 
    2945                 2950                 2955             


Lys Ile  Leu Trp His Thr Met  Lys Asn Tyr Tyr Arg  Ile Leu Met 
    2960                 2965                 2970             


Arg Arg  Asp Gln Val Phe Lys  Val Cys Ala Asn His  Val Ile Thr 
    2975                 2980                 2985             


Lys Thr  Met Glu Leu Lys Pro  Leu Asn Val Ser Asn  Asn Ala Leu 
    2990                 2995                 3000             


Val Trp  Thr Ala Ser Asp Tyr  Ala Asp Gly Glu Ala  Lys Val Glu 
    3005                 3010                 3015             


Gln Leu  Ala Val Arg Phe Lys  Thr Lys Glu Val Ala  Asp Cys Phe 
    3020                 3025                 3030             


Lys Lys  Thr Phe Glu Glu Cys  Gln Gln Asn Leu Met  Lys Leu Gln 
    3035                 3040                 3045             


Lys Gly  His Val Ser Leu Ala  Ala Glu Leu Ser Lys  Glu Thr Asn 
    3050                 3055                 3060             


Pro Val  Val Phe Phe Asp Val  Cys Ala Asp Gly Glu  Pro Leu Gly 
    3065                 3070                 3075             


Arg Ile  Thr Met Glu Leu Phe  Ser Asn Ile Val Pro  Arg Thr Ala 
    3080                 3085                 3090             


Glu Asn  Phe Arg Ala Leu Cys  Thr Gly Glu Lys Gly  Phe Gly Phe 
    3095                 3100                 3105             


Lys Asn  Ser Ile Phe His Arg  Val Ile Pro Asp Phe  Val Cys Gln 
    3110                 3115                 3120             


Gly Gly  Asp Ile Thr Lys His  Asp Gly Thr Gly Gly  Gln Ser Ile 
    3125                 3130                 3135             


Tyr Gly  Asp Lys Phe Glu Asp  Glu Asn Phe Asp Val  Lys His Thr 
    3140                 3145                 3150             


Gly Pro  Gly Leu Leu Ser Met  Ala Asn Gln Gly Gln  Asn Thr Asn 
    3155                 3160                 3165             


Asn Ser  Gln Phe Val Ile Thr  Leu Lys Lys Ala Glu  His Leu Asp 
    3170                 3175                 3180             


Phe Lys  His Val Val Phe Gly  Phe Val Lys Asp Gly  Met Asp Thr 
    3185                 3190                 3195             


Val Lys  Lys Ile Glu Ser Phe  Gly Ser Pro Lys Gly  Ser Val Cys 
    3200                 3205                 3210             


Arg Arg  Ile Thr Ile Thr Glu  Cys Gly Gln Ile 
    3215                 3220                 


<210>  183
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Ala Ala Ser Ala Ala Val Phe Ser Arg Leu Arg Ser Gly Leu Arg 
1               5                   10                  15      


Leu Gly Ser Arg Gly Leu Cys Thr Arg Leu Ala Thr Pro Pro Arg Arg 
            20                  25                  30          


Ala Pro Asp Gln Ala Ala Glu Ile Gly Ser Arg Gly Ser Thr Lys Ala 
        35                  40                  45              


Gln Gly Pro Gln Gln Gln Pro Gly Ser Glu Gly Pro Ser Tyr Ala Lys 
    50                  55                  60                  


Lys Val Ala Leu Trp Leu Ala Gly Leu Leu Gly Ala Gly Gly Thr Val 
65                  70                  75                  80  


Ser Val Val Tyr Ile Phe Gly Asn Asn Pro Val Asp Glu Asn Gly Ala 
                85                  90                  95      


Lys Ile Pro Asp Glu Phe Asp Asn Asp Pro Ile Leu Val Gln Gln Leu 
            100                 105                 110         


Arg Arg Thr Tyr Lys Tyr Phe Lys Asp Tyr Arg Gln Met Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Pro Cys Leu Leu Pro Asp Pro Leu Gln Glu Pro Tyr Tyr 
    130                 135                 140                 


Gln Pro Pro Tyr Thr Leu Val Leu Glu Leu Thr Gly Val Leu Leu His 
145                 150                 155                 160 


Pro Glu Trp Ser Leu Ala Thr Gly Trp Arg Phe Lys Lys Arg Pro Gly 
                165                 170                 175     


Ile Glu Thr Leu Phe Gln Gln Leu Ala Pro Leu Tyr Glu Ile Val Ile 
            180                 185                 190         


Phe Thr Ser Glu Thr Gly Met Thr Ala Phe Pro Leu Ile Asp Ser Val 
        195                 200                 205             


Asp Pro His Gly Phe Ile Ser Tyr Arg Leu Phe Arg Asp Ala Thr Arg 
    210                 215                 220                 


Tyr Met Asp Gly His His Val Lys Asp Ile Ser Cys Leu Asn Arg Asp 
225                 230                 235                 240 


Pro Ala Arg Val Val Val Val Asp Cys Lys Lys Glu Ala Phe Arg Leu 
                245                 250                 255     


Gln Pro Tyr Asn Gly Val Ala Leu Arg Pro Trp Asp Gly Asn Ser Asp 
            260                 265                 270         


Asp Arg Val Leu Leu Asp Leu Ser Ala Phe Leu Lys Thr Ile Ala Leu 
        275                 280                 285             


Asn Gly Val Glu Asp Val Arg Thr Val Leu Glu His Tyr Ala Leu Glu 
    290                 295                 300                 


Asp Asp Pro Leu Ala Ala Phe Lys Gln Arg Gln Ser Arg Leu Glu Gln 
305                 310                 315                 320 


Glu Glu Gln Gln Arg Leu Ala Glu Leu Ser Lys Ser Asn Lys Gln Asn 
                325                 330                 335     


Leu Phe Leu Gly Ser Leu Thr Ser Arg Leu Trp Pro Arg Ser Lys Gln 
            340                 345                 350         


Pro 
    


<210>  184
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
65                  70                  75                  80  


Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                85                  90                  95      


Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
            100                 105                 110         


Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
        115                 120                 125             


Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
    130                 135                 140                 


Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
145                 150                 155                 160 


Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                165                 170                 175     


Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
            180                 185                 190         


Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
        195                 200                 205             


Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
    210                 215                 220                 


Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
225                 230                 235                 240 


Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                245                 250                 255     


Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
            260                 265                 270         


Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln 
        275                 280                 285             


Asn Trp Asn Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn 
    290                 295                 300                 


Tyr Gly Tyr Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr 
305                 310                 315                 320 


Thr Gly Tyr Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln 
                325                 330                 335     


Ser Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr 
            340                 345                 350         


Lys Pro Tyr 
        355 


<210>  185
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Arg Pro Met Arg Ile Phe Val Asn Asp Asp Arg His Val Met Ala 
1               5                   10                  15      


Lys His Ser Ser Val Tyr Pro Thr Gln Glu Glu Leu Glu Ala Val Gln 
            20                  25                  30          


Asn Met Val Ser His Thr Glu Arg Ala Leu Lys Ala Val Ser Asp Trp 
        35                  40                  45              


Ile Asp Glu Gln Glu Lys Gly Ser Ser Glu Gln Ala Glu Ser Asp Asn 
    50                  55                  60                  


Met Asp Val Pro Pro Glu Asp Asp Ser Lys Glu Gly Ala Gly Glu Gln 
65                  70                  75                  80  


Lys Thr Glu His Met Thr Arg Thr Leu Arg Gly Val Met Arg Val Gly 
                85                  90                  95      


Leu Val Ala Lys Gly Leu Leu Leu Lys Gly Asp Leu Asp Leu Glu Leu 
            100                 105                 110         


Val Leu Leu Cys Lys Glu Lys Pro Thr Thr Ala Leu Leu Asp Lys Val 
        115                 120                 125             


Ala Asp Asn Leu Ala Ile Gln Leu Ala Ala Val Thr Glu Asp Lys Tyr 
    130                 135                 140                 


Glu Ile Leu Gln Ser Val Asp Asp Ala Ala Ile Val Ile Lys Asn Thr 
145                 150                 155                 160 


Lys Glu Pro Pro Leu Ser Leu Thr Ile His Leu Thr Ser Pro Val Val 
                165                 170                 175     


Arg Glu Glu Met Glu Lys Val Leu Ala Gly Glu Thr Leu Ser Val Asn 
            180                 185                 190         


Asp Pro Pro Asp Val Leu Asp Arg Gln Lys Cys Leu Ala Ala Leu Ala 
        195                 200                 205             


Ser Leu Arg His Ala Lys Trp Phe Gln Ala Arg Ala Asn Gly Leu Lys 
    210                 215                 220                 


Ser Cys Val Ile Val Ile Arg Val Leu Arg Asp Leu Cys Thr Arg Val 
225                 230                 235                 240 


Pro Thr Trp Gly Pro Leu Arg Gly Trp Pro Leu Glu Leu Leu Cys Glu 
                245                 250                 255     


Lys Ser Ile Gly Thr Ala Asn Arg Pro Met Gly Ala Gly Glu Ala Leu 
            260                 265                 270         


Arg Arg Val Leu Glu Cys Leu Ala Ser Gly Ile Val Met Pro Asp Gly 
        275                 280                 285             


Ser Gly Ile Tyr Asp Pro Cys Glu Lys Glu Ala Thr Asp Ala Ile Gly 
    290                 295                 300                 


His Leu Asp Arg Gln Gln Arg Glu Asp Ile Thr Gln Ser Ala Gln His 
305                 310                 315                 320 


Ala Leu Arg Leu Ala Ala Phe Gly Gln Leu His Lys Val Leu Gly Met 
                325                 330                 335     


Asp Pro Leu Pro Ser Lys Met Pro Lys Lys Pro Lys Asn Glu Asn Pro 
            340                 345                 350         


Val Asp Tyr Thr Val Gln Ile Pro Pro Ser Thr Thr Tyr Ala Ile Thr 
        355                 360                 365             


Pro Met Lys Arg Pro Met Glu Glu Asp Gly Glu Glu Lys Ser Pro Ser 
    370                 375                 380                 


Lys Lys Lys Lys Lys Ile Gln Lys Lys Glu Glu Lys Ala Glu Pro Pro 
385                 390                 395                 400 


Gln Ala Met Asn Ala Leu Met Arg Leu Asn Gln Leu Lys Pro Gly Leu 
                405                 410                 415     


Gln Tyr Lys Leu Val Ser Gln Thr Gly Pro Val His Ala Pro Ile Phe 
            420                 425                 430         


Thr Met Ser Val Glu Val Asp Gly Asn Ser Phe Glu Ala Ser Gly Pro 
        435                 440                 445             


Ser Lys Lys Thr Ala Lys Leu His Val Ala Val Lys Val Leu Gln Asp 
    450                 455                 460                 


Met Gly Leu Pro Thr Gly Ala Glu Gly Arg Asp Ser Ser Lys Gly Glu 
465                 470                 475                 480 


Asp Ser Ala Glu Glu Thr Glu Ala Lys Pro Ala Val Val Ala Pro Ala 
                485                 490                 495     


Pro Val Val Glu Ala Val Ser Thr Pro Ser Ala Ala Phe Pro Ser Asp 
            500                 505                 510         


Ala Thr Ala Glu Gln Gly Pro Ile Leu Thr Lys His Gly Lys Asn Pro 
        515                 520                 525             


Val Met Glu Leu Asn Glu Lys Arg Arg Gly Leu Lys Tyr Glu Leu Ile 
    530                 535                 540                 


Ser Glu Thr Gly Gly Ser His Asp Lys Arg Phe Val Met Glu Val Glu 
545                 550                 555                 560 


Val Asp Gly Gln Lys Phe Gln Gly Ala Gly Ser Asn Lys Lys Val Ala 
                565                 570                 575     


Lys Ala Tyr Ala Ala Leu Ala Ala Leu Glu Lys Leu Phe Pro Asp Thr 
            580                 585                 590         


Pro Leu Ala Leu Asp Ala Asn Lys Lys Lys Arg Ala Pro Val Pro Val 
        595                 600                 605             


Arg Gly Gly Pro Lys Phe Ala Ala Lys Pro His Asn Pro Gly Phe Gly 
    610                 615                 620                 


Met Gly Gly Pro Met His Asn Glu Val Pro Pro Pro Pro Asn Leu Arg 
625                 630                 635                 640 


Gly Arg Gly Arg Gly Gly Ser Ile Arg Gly Arg Gly Arg Gly Arg Gly 
                645                 650                 655     


Phe Gly Gly Ala Asn His Gly Gly Tyr Met Asn Ala Gly Ala Gly Tyr 
            660                 665                 670         


Gly Ser Tyr Gly Tyr Gly Gly Asn Ser Ala Thr Ala Gly Tyr Ser Gln 
        675                 680                 685             


Phe Tyr Ser Asn Gly Gly His Ser Gly Asn Ala Ser Gly Gly Gly Gly 
    690                 695                 700                 


Gly Gly Gly Gly Gly Ser Ser Gly Tyr Gly Ser Tyr Tyr Gln Gly Asp 
705                 710                 715                 720 


Asn Tyr Asn Ser Pro Val Pro Pro Lys His Ala Gly Lys Lys Gln Pro 
                725                 730                 735     


His Gly Gly Gln Gln Lys Pro Ser Tyr Gly Ser Gly Tyr Gln Ser His 
            740                 745                 750         


Gln Gly Gln Gln Gln Ser Tyr Asn Gln Ser Pro Tyr Ser Asn Tyr Gly 
        755                 760                 765             


Pro Pro Gln Gly Lys Gln Lys Gly Tyr Asn His Gly Gln Gly Ser Tyr 
    770                 775                 780                 


Ser Tyr Ser Asn Ser Tyr Asn Ser Pro Gly Gly Gly Gly Gly Ser Asp 
785                 790                 795                 800 


Tyr Asn Tyr Glu Ser Lys Phe Asn Tyr Ser Gly Ser Gly Gly Arg Ser 
                805                 810                 815     


Gly Gly Asn Ser Tyr Gly Ser Gly Gly Ala Ser Tyr Asn Pro Gly Ser 
            820                 825                 830         


His Gly Gly Tyr Gly Gly Gly Ser Gly Gly Gly Ser Ser Tyr Gln Gly 
        835                 840                 845             


Lys Gln Gly Gly Tyr Ser Gln Ser Asn Tyr Asn Ser Pro Gly Ser Gly 
    850                 855                 860                 


Gln Asn Tyr Ser Gly Pro Pro Ser Ser Tyr Gln Ser Ser Gln Gly Gly 
865                 870                 875                 880 


Tyr Gly Arg Asn Ala Asp His Ser Met Asn Tyr Gln Tyr Arg 
                885                 890                 


<210>  186
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn 
1               5                   10                  15      


Thr Glu Thr Asn Glu Lys Ala Leu Glu Ala Val Phe Gly Lys Tyr Gly 
            20                  25                  30          


Arg Ile Val Glu Val Leu Leu Met Lys Asp Arg Glu Thr Asn Lys Ser 
        35                  40                  45              


Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp 
    50                  55                  60                  


Ala Ala Arg Asp Met Asn Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys 
65                  70                  75                  80  


Val Glu Gln Ala Thr Lys Pro Ser Phe Glu Ser Gly Arg Arg Gly Pro 
                85                  90                  95      


Pro Pro Pro Pro Arg Ser Arg Gly Pro Pro Arg Gly Leu Arg Gly Gly 
            100                 105                 110         


Arg Gly Gly Ser Gly Gly Thr Arg Gly Pro Pro Ser Arg Gly Gly His 
        115                 120                 125             


Met Asp Asp Gly Gly Tyr Ser Met Asn Phe Asn Met Ser Ser Ser Arg 
    130                 135                 140                 


Gly Pro Leu Pro Val Lys Arg Gly Pro Pro Pro Arg Ser Gly Gly Pro 
145                 150                 155                 160 


Pro Pro Lys Arg Ser Ala Pro Ser Gly Pro Val Arg Ser Ser Ser Gly 
                165                 170                 175     


Met Gly Gly Arg Ala Pro Val Ser Arg Gly Arg Asp Ser Tyr Gly Gly 
            180                 185                 190         


Pro Pro Arg Arg Glu Pro Leu Pro Ser Arg Arg Asp Val Tyr Leu Ser 
        195                 200                 205             


Pro Arg Asp Asp Gly Tyr Ser Thr Lys Asp Ser Tyr Ser Ser Arg Asp 
    210                 215                 220                 


Tyr Pro Ser Ser Arg Asp Thr Arg Asp Tyr Ala Pro Pro Pro Arg Asp 
225                 230                 235                 240 


Tyr Thr Tyr Arg Asp Tyr Gly His Ser Ser Ser Arg Asp Asp Tyr Pro 
                245                 250                 255     


Ser Arg Gly Tyr Ser Asp Arg Asp Gly Tyr Gly Arg Asp Arg Asp Tyr 
            260                 265                 270         


Ser Asp His Pro Ser Gly Gly Ser Tyr Arg Asp Ser Tyr Glu Ser Tyr 
        275                 280                 285             


Gly Asn Ser Arg Ser Ala Pro Pro Thr Arg Gly Pro Pro Pro Ser Tyr 
    290                 295                 300                 


Gly Gly Ser Ser Arg Tyr Asp Asp Tyr Ser Ser Ser Arg Asp Gly Tyr 
305                 310                 315                 320 


Gly Gly Ser Arg Asp Ser Tyr Ser Ser Ser Arg Ser Asp Leu Tyr Ser 
                325                 330                 335     


Ser Gly Arg Asp Arg Val Gly Arg Gln Glu Arg Gly Leu Pro Pro Ser 
            340                 345                 350         


Met Glu Arg Gly Tyr Pro Pro Pro Arg Asp Ser Tyr Ser Ser Ser Ser 
        355                 360                 365             


Arg Gly Ala Pro Arg Gly Gly Gly Arg Gly Gly Ser Arg Ser Asp Arg 
    370                 375                 380                 


Gly Gly Gly Arg Ser Arg Tyr 
385                 390     


<210>  187
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys 
1               5                   10                  15      


His Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser 
            20                  25                  30          


Thr Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu 
        35                  40                  45              


Arg Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile 
    50                  55                  60                  


Cys Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile 
65                  70                  75                  80  


Thr Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly 
                85                  90                  95      


Glu Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His 
            100                 105                 110         


Arg Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys 
        115                 120                 125             


Ile Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala 
    130                 135                 140                 


Arg Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile 
145                 150                 155                 160 


Gln Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp 
                165                 170                 175     


Thr Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile 
            180                 185                 190         


Gly Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val 
        195                 200                 205             


His Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn 
    210                 215                 220                 


Ile Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg 
225                 230                 235                 240 


Gly Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu 
                245                 250                 255     


Ala Ala Lys Gln Ser Ser Gly 
            260             


<210>  188
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp Met Ser Gly 
1               5                   10                  15      


Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg Glu Gly Ser 
            20                  25                  30          


Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln Leu Arg Phe 
        35                  40                  45              


Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu 
    50                  55                  60                  


Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp Pro Val Ser 
65                  70                  75                  80  


Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly Phe Leu Lys 
                85                  90                  95      


Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe Glu Ala Leu 
            100                 105                 110         


Asn Asn Lys Asn Cys Gln Ala Leu Arg Ala Lys Pro Lys Val Tyr Ile 
        115                 120                 125             


Ile Gln Ala Cys Arg Gly Glu Gln Arg Asp Pro Gly Glu Thr Val Gly 
    130                 135                 140                 


Gly Asp Glu Ile Val Met Val Ile Lys Asp Ser Pro Gln Thr Ile Pro 
145                 150                 155                 160 


Thr Tyr Thr Asp Ala Leu His Val Tyr Ser Thr Val Glu Gly Tyr Ile 
                165                 170                 175     


Ala Tyr Arg His Asp Gln Lys Gly Ser Cys Phe Ile Gln Thr Leu Val 
            180                 185                 190         


Asp Val Phe Thr Lys Arg Lys Gly His Ile Leu Glu Leu Leu Thr Glu 
        195                 200                 205             


Val Thr Arg Arg Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys Ala 
    210                 215                 220                 


Arg Lys Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg Lys Arg Leu Tyr 
225                 230                 235                 240 


Leu Gln 
        


<210>  189
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  190
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Gly Pro Ala Trp Ile Ser Lys Val Ser Arg Leu Leu Gly Ala 
1               5                   10                  15      


Phe His Asn Pro Lys Gln Val Thr Arg Gly Phe Thr Gly Gly Val Gln 
            20                  25                  30          


Thr Val Thr Leu Ile Pro Gly Asp Gly Ile Gly Pro Glu Ile Ser Ala 
        35                  40                  45              


Ala Val Met Lys Ile Phe Asp Ala Ala Lys Ala Pro Ile Gln Trp Glu 
    50                  55                  60                  


Glu Arg Asn Val Thr Ala Ile Gln Gly Pro Gly Gly Lys Trp Met Ile 
65                  70                  75                  80  


Pro Ser Glu Ala Lys Glu Ser Met Asp Lys Asn Lys Met Gly Leu Lys 
                85                  90                  95      


Gly Pro Leu Lys Thr Pro Ile Ala Ala Gly His Pro Ser Met Asn Leu 
            100                 105                 110         


Leu Leu Arg Lys Thr Phe Asp Leu Tyr Ala Asn Val Arg Pro Cys Val 
        115                 120                 125             


Ser Ile Glu Gly Tyr Lys Thr Pro Tyr Thr Asp Val Asn Ile Val Thr 
    130                 135                 140                 


Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile Glu His Val Ile 
145                 150                 155                 160 


Val Asp Gly Val Val Gln Ser Ile Lys Leu Ile Thr Glu Gly Ala Ser 
                165                 170                 175     


Lys Arg Ile Ala Glu Phe Ala Phe Glu Tyr Ala Arg Asn Asn His Arg 
            180                 185                 190         


Ser Asn Val Thr Ala Val His Lys Ala Asn Ile Met Arg Met Ser Asp 
        195                 200                 205             


Gly Leu Phe Leu Gln Lys Cys Arg Glu Val Ala Glu Ser Cys Lys Asp 
    210                 215                 220                 


Ile Lys Phe Asn Glu Met Tyr Leu Asp Thr Val Cys Leu Asn Met Val 
225                 230                 235                 240 


Gln Asp Pro Ser Gln Phe Asp Val Leu Val Met Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Leu Cys Ala Gly Leu Ile Gly Gly Leu Gly Val 
            260                 265                 270         


Thr Pro Ser Gly Asn Ile Gly Ala Asn Gly Val Ala Ile Phe Glu Ser 
        275                 280                 285             


Val His Gly Thr Ala Pro Asp Ile Ala Gly Lys Asp Met Ala Asn Pro 
    290                 295                 300                 


Thr Ala Leu Leu Leu Ser Ala Val Met Met Leu Arg His Met Gly Leu 
305                 310                 315                 320 


Phe Asp His Ala Ala Arg Ile Glu Ala Ala Cys Phe Ala Thr Ile Lys 
                325                 330                 335     


Asp Gly Lys Ser Leu Thr Lys Asp Leu Gly Gly Asn Ala Lys Cys Ser 
            340                 345                 350         


Asp Phe Thr Glu Glu Ile Cys Arg Arg Val Lys Asp Leu Asp 
        355                 360                 365     


<210>  191
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Thr Leu Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro 
1               5                   10                  15      


Ser Phe Pro Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu 
            20                  25                  30          


Thr Thr Gln Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu 
        35                  40                  45              


Leu Arg Arg Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu 
    50                  55                  60                  


Trp Asn Lys Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys 
65                  70                  75                  80  


Asn Tyr Arg His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys 
                85                  90                  95      


Gly Glu Asn Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala 
            100                 105                 110         


Ile Gln Ser Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly 
        115                 120                 125             


Pro Lys Thr Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp 
    130                 135                 140                 


Tyr Ser Ser Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln 
145                 150                 155                 160 


Lys Val Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn 
                165                 170                 175     


Trp Ala Asn Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala 
            180                 185                 190         


Ser Cys Pro Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys 
        195                 200                 205             


Tyr Glu Asp Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr 
    210                 215                 220                 


Cys Lys His Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr 
                245 


<210>  192
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly 
1               5                   10                  15      


Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala 
            20                  25                  30          


Leu Ala Gly Leu Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly 
        35                  40                  45              


Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser 
    50                  55                  60                  


Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg 
65                  70                  75                  80  


Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met 
                85                  90                  95      


Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala 
            100                 105                 110         


Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg 
        115                 120                 125             


Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu 
    130                 135                 140                 


Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr 
145                 150                 155                 160 


Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile 
                165                 170                 175     


Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn 
            180                 185                 190         


Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser 
        195                 200                 205             


Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val 
    210                 215                 220                 


Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp 
225                 230                 235                 240 


Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly 
                245                 250                 255     


Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg 
            260                 265                 270         


Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln 
        275                 280                 285             


Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys 
    290                 295                 300                 


Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro 
305                 310                 315                 320 


Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe 
                325                 330                 335     


Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn 
            340                 345                 350         


Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg 
        355                 360                 365             


Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp 
    370                 375                 380                 


Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu 
385                 390                 395                 400 


Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His 
                405                 410                 415     


Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser 
            420                 425                 430         


Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys 
        435                 440                 445             


Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro 
    450                 455                 460                 


Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg 
465                 470                 475                 480 


Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn 
                485                 490                 495     


Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu 
            500                 505                 510         


Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser 
        515                 520                 525             


Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp 
    530                 535                 540                 


Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln 
545                 550                 555                 560 


Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val 
                565                 570                 575     


Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg 
            580                 585                 590         


Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu 
        595                 600                 605             


Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu 
    610                 615                 620                 


Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile 
625                 630                 635                 640 


Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg 
                645                 650                 655     


Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu 
            660                 665                 670         


Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met 
        675                 680                 685             


Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys 
    690                 695                 700                 


Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser 
705                 710                 715                 720 


Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu 
                725                 730                 735     


Asn Leu Ala Ser Trp Arg Glu Ala Ser 
            740                 745 


<210>  193
<211>  3859
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr 
1               5                   10                  15      


Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn 
            20                  25                  30          


Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn 
        35                  40                  45              


Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His 
    50                  55                  60                  


Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile 
                85                  90                  95      


Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn 
            100                 105                 110         


Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn 
        115                 120                 125             


Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg 
    130                 135                 140                 


Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln 
145                 150                 155                 160 


Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro 
                165                 170                 175     


Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met 
            180                 185                 190         


Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu 
        195                 200                 205             


Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val 
    210                 215                 220                 


Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys 
225                 230                 235                 240 


Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn 
                245                 250                 255     


Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr 
            260                 265                 270         


Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu 
        275                 280                 285             


Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys 
    290                 295                 300                 


Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys 
305                 310                 315                 320 


Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys 
                325                 330                 335     


His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp 
            340                 345                 350         


Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg 
        355                 360                 365             


Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His 
    370                 375                 380                 


His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln 
385                 390                 395                 400 


Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln 
                405                 410                 415     


Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser 
            420                 425                 430         


Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met 
        435                 440                 445             


Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu 
    450                 455                 460                 


Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val 
465                 470                 475                 480 


Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro 
                485                 490                 495     


Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu 
        515                 520                 525             


Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr 
    530                 535                 540                 


Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile 
545                 550                 555                 560 


Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile 
                565                 570                 575     


Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu 
            580                 585                 590         


Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala 
        595                 600                 605             


Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg 
    610                 615                 620                 


Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr 
625                 630                 635                 640 


Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro 
                645                 650                 655     


Tyr Met Val Glu Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala 
            660                 665                 670         


Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile 
        675                 680                 685             


Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val 
    690                 695                 700                 


Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser 
705                 710                 715                 720 


Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu 
                725                 730                 735     


His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu 
            740                 745                 750         


Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly 
        755                 760                 765             


Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro 
    770                 775                 780                 


Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln 
785                 790                 795                 800 


His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg 
                805                 810                 815     


Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val 
            820                 825                 830         


Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr 
        835                 840                 845             


Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His 
    850                 855                 860                 


Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu 
865                 870                 875                 880 


Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly 
                885                 890                 895     


Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu 
            900                 905                 910         


His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe 
        915                 920                 925             


Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu 
    930                 935                 940                 


Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg 
945                 950                 955                 960 


Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser 
                965                 970                 975     


Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn 
            980                 985                 990         


Phe Thr Glu Lys Thr Ile Pro Asn  Val Ile Ile Ser His  Arg Tyr Lys 
        995                 1000                 1005             


Ala Gln  Asp Thr Pro Ala Arg  Lys Thr Phe Glu Gln  Ala Leu Thr 
    1010                 1015                 1020             


Gly Ala  Phe Met Ser Ala Val  Ile Lys Asp Leu Arg  Pro Ser Ala 
    1025                 1030                 1035             


Leu Pro  Phe Val Ala Ser Leu  Ile Arg His Tyr Thr  Met Val Ala 
    1040                 1045                 1050             


Val Ala  Gln Gln Cys Gly Pro  Phe Leu Leu Pro Cys  Tyr Gln Val 
    1055                 1060                 1065             


Gly Ser  Gln Pro Ser Thr Ala  Met Phe His Ser Glu  Glu Asn Gly 
    1070                 1075                 1080             


Ser Lys  Gly Met Asp Pro Leu  Val Leu Ile Asp Ala  Ile Ala Ile 
    1085                 1090                 1095             


Cys Met  Ala Tyr Glu Glu Lys  Glu Leu Cys Lys Ile  Gly Glu Val 
    1100                 1105                 1110             


Ala Leu  Ala Val Ile Phe Asp  Val Ala Ser Ile Ile  Leu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Arg Ala Cys Gln Leu  Pro Leu Phe Ser Tyr  Ile Val Glu 
    1130                 1135                 1140             


Arg Leu  Cys Ala Cys Cys Tyr  Glu Gln Ala Trp Tyr  Ala Lys Leu 
    1145                 1150                 1155             


Gly Gly  Val Val Ser Ile Lys  Phe Leu Met Glu Arg  Leu Pro Leu 
    1160                 1165                 1170             


Thr Trp  Val Leu Gln Asn Gln  Gln Thr Phe Leu Lys  Ala Leu Leu 
    1175                 1180                 1185             


Phe Val  Met Met Asp Leu Thr  Gly Glu Val Ser Asn  Gly Ala Val 
    1190                 1195                 1200             


Ala Met  Ala Lys Thr Thr Leu  Glu Gln Leu Leu Met  Arg Cys Ala 
    1205                 1210                 1215             


Thr Pro  Leu Lys Asp Glu Glu  Arg Ala Glu Glu Ile  Val Ala Ala 
    1220                 1225                 1230             


Gln Glu  Lys Ser Phe His His  Val Thr His Asp Leu  Val Arg Glu 
    1235                 1240                 1245             


Val Thr  Ser Pro Asn Ser Thr  Val Arg Lys Gln Ala  Met His Ser 
    1250                 1255                 1260             


Leu Gln  Val Leu Ala Gln Val  Thr Gly Lys Ser Val  Thr Val Ile 
    1265                 1270                 1275             


Met Glu  Pro His Lys Glu Val  Leu Gln Asp Met Val  Pro Pro Lys 
    1280                 1285                 1290             


Lys His  Leu Leu Arg His Gln  Pro Ala Asn Ala Gln  Ile Gly Leu 
    1295                 1300                 1305             


Met Glu  Gly Asn Thr Phe Cys  Thr Thr Leu Gln Pro  Arg Leu Phe 
    1310                 1315                 1320             


Thr Met  Asp Leu Asn Val Val  Glu His Lys Val Phe  Tyr Thr Glu 
    1325                 1330                 1335             


Leu Leu  Asn Leu Cys Glu Ala  Glu Asp Ser Ala Leu  Thr Lys Leu 
    1340                 1345                 1350             


Pro Cys  Tyr Lys Ser Leu Pro  Ser Leu Val Pro Leu  Arg Ile Ala 
    1355                 1360                 1365             


Ala Leu  Asn Ala Leu Ala Ala  Cys Asn Tyr Leu Pro  Gln Ser Arg 
    1370                 1375                 1380             


Glu Lys  Ile Ile Ala Ala Leu  Phe Lys Ala Leu Asn  Ser Thr Asn 
    1385                 1390                 1395             


Ser Glu  Leu Gln Glu Ala Gly  Glu Ala Cys Met Arg  Lys Phe Leu 
    1400                 1405                 1410             


Glu Gly  Ala Thr Ile Glu Val  Asp Gln Ile His Thr  His Met Arg 
    1415                 1420                 1425             


Pro Leu  Leu Met Met Leu Gly  Asp Tyr Arg Ser Leu  Thr Leu Asn 
    1430                 1435                 1440             


Val Val  Asn Arg Leu Thr Ser  Val Thr Arg Leu Phe  Pro Asn Ser 
    1445                 1450                 1455             


Phe Asn  Asp Lys Phe Cys Asp  Gln Met Met Gln His  Leu Arg Lys 
    1460                 1465                 1470             


Trp Met  Glu Val Val Val Ile  Thr His Lys Gly Gly  Gln Arg Ser 
    1475                 1480                 1485             


Asp Gly  Asn Glu Ser Ile Ser  Glu Cys Gly Arg Cys  Pro Leu Ser 
    1490                 1495                 1500             


Pro Phe  Cys Gln Phe Glu Glu  Met Lys Ile Cys Ser  Ala Ile Ile 
    1505                 1510                 1515             


Asn Leu  Phe His Leu Ile Pro  Ala Ala Pro Gln Thr  Leu Val Lys 
    1520                 1525                 1530             


Pro Leu  Leu Glu Val Val Met  Lys Thr Glu Arg Ala  Met Leu Ile 
    1535                 1540                 1545             


Glu Ala  Gly Ser Pro Phe Arg  Glu Pro Leu Ile Lys  Phe Leu Thr 
    1550                 1555                 1560             


Arg His  Pro Ser Gln Thr Val  Glu Leu Phe Met Met  Glu Ala Thr 
    1565                 1570                 1575             


Leu Asn  Asp Pro Gln Trp Ser  Arg Met Phe Met Ser  Phe Leu Lys 
    1580                 1585                 1590             


His Lys  Asp Ala Arg Pro Leu  Arg Asp Val Leu Ala  Ala Asn Pro 
    1595                 1600                 1605             


Asn Arg  Phe Ile Thr Leu Leu  Leu Pro Gly Gly Ala  Gln Thr Ala 
    1610                 1615                 1620             


Val Arg  Pro Gly Ser Pro Ser  Thr Ser Thr Met Arg  Leu Asp Leu 
    1625                 1630                 1635             


Gln Phe  Gln Ala Ile Lys Ile  Ile Ser Ile Ile Val  Lys Asn Asp 
    1640                 1645                 1650             


Asp Ser  Trp Leu Ala Ser Gln  His Ser Leu Val Ser  Gln Leu Arg 
    1655                 1660                 1665             


Arg Val  Trp Val Ser Glu Asn  Phe Gln Glu Arg His  Arg Lys Glu 
    1670                 1675                 1680             


Asn Met  Ala Ala Thr Asn Trp  Lys Glu Pro Lys Leu  Leu Ala Tyr 
    1685                 1690                 1695             


Cys Leu  Leu Asn Tyr Cys Lys  Arg Asn Tyr Gly Asp  Ile Glu Leu 
    1700                 1705                 1710             


Leu Phe  Gln Leu Leu Arg Ala  Phe Thr Gly Arg Phe  Leu Cys Asn 
    1715                 1720                 1725             


Met Thr  Phe Leu Lys Glu Tyr  Met Glu Glu Glu Ile  Pro Lys Asn 
    1730                 1735                 1740             


Tyr Ser  Ile Ala Gln Lys Arg  Ala Leu Phe Phe Arg  Phe Val Asp 
    1745                 1750                 1755             


Phe Asn  Asp Pro Asn Phe Gly  Asp Glu Leu Lys Ala  Lys Val Leu 
    1760                 1765                 1770             


Gln His  Ile Leu Asn Pro Ala  Phe Leu Tyr Ser Phe  Glu Lys Gly 
    1775                 1780                 1785             


Glu Gly  Glu Gln Leu Leu Gly  Pro Pro Asn Pro Glu  Gly Asp Asn 
    1790                 1795                 1800             


Pro Glu  Ser Ile Thr Ser Val  Phe Ile Thr Lys Val  Leu Asp Pro 
    1805                 1810                 1815             


Glu Lys  Gln Ala Asp Met Leu  Asp Ser Leu Arg Ile  Tyr Leu Leu 
    1820                 1825                 1830             


Gln Tyr  Ala Thr Leu Leu Val  Glu His Ala Pro His  His Ile His 
    1835                 1840                 1845             


Asp Asn  Asn Lys Asn Arg Asn  Ser Lys Leu Arg Arg  Leu Met Thr 
    1850                 1855                 1860             


Phe Ala  Trp Pro Cys Leu Leu  Ser Lys Ala Cys Val  Asp Pro Ala 
    1865                 1870                 1875             


Cys Lys  Tyr Ser Gly His Leu  Leu Leu Ala His Ile  Ile Ala Lys 
    1880                 1885                 1890             


Phe Ala  Ile His Lys Lys Ile  Val Leu Gln Val Phe  His Ser Leu 
    1895                 1900                 1905             


Leu Lys  Ala His Ala Met Glu  Ala Arg Ala Ile Val  Arg Gln Ala 
    1910                 1915                 1920             


Met Ala  Ile Leu Thr Pro Ala  Val Pro Ala Arg Met  Glu Asp Gly 
    1925                 1930                 1935             


His Gln  Met Leu Thr His Trp  Thr Arg Lys Ile Ile  Val Glu Glu 
    1940                 1945                 1950             


Gly His  Thr Val Pro Gln Leu  Val His Ile Leu His  Leu Ile Val 
    1955                 1960                 1965             


Gln His  Phe Lys Val Tyr Tyr  Pro Val Arg His His  Leu Val Gln 
    1970                 1975                 1980             


His Met  Val Ser Ala Met Gln  Arg Leu Gly Phe Thr  Pro Ser Val 
    1985                 1990                 1995             


Thr Ile  Glu Gln Arg Arg Leu  Ala Val Asp Leu Ser  Glu Val Val 
    2000                 2005                 2010             


Ile Lys  Trp Glu Leu Gln Arg  Ile Lys Asp Gln Gln  Pro Asp Ser 
    2015                 2020                 2025             


Asp Met  Asp Pro Asn Ser Ser  Gly Glu Gly Val Asn  Ser Val Ser 
    2030                 2035                 2040             


Ser Ser  Ile Lys Arg Gly Leu  Ser Val Asp Ser Ala  Gln Glu Val 
    2045                 2050                 2055             


Lys Arg  Phe Arg Thr Ala Thr  Gly Ala Ile Ser Ala  Val Phe Gly 
    2060                 2065                 2070             


Arg Ser  Gln Ser Leu Pro Gly  Ala Asp Ser Leu Leu  Ala Lys Pro 
    2075                 2080                 2085             


Ile Asp  Lys Gln His Thr Asp  Thr Val Val Asn Phe  Leu Ile Arg 
    2090                 2095                 2100             


Val Ala  Cys Gln Val Asn Asp  Asn Thr Asn Thr Ala  Gly Ser Pro 
    2105                 2110                 2115             


Gly Glu  Val Leu Ser Arg Arg  Cys Val Asn Leu Leu  Lys Thr Ala 
    2120                 2125                 2130             


Leu Arg  Pro Asp Met Trp Pro  Lys Ser Glu Leu Lys  Leu Gln Trp 
    2135                 2140                 2145             


Phe Asp  Lys Leu Leu Met Thr  Val Glu Gln Pro Asn  Gln Val Asn 
    2150                 2155                 2160             


Tyr Gly  Asn Ile Cys Thr Gly  Leu Glu Val Leu Ser  Phe Leu Leu 
    2165                 2170                 2175             


Thr Val  Leu Gln Ser Pro Ala  Ile Leu Ser Ser Phe  Lys Pro Leu 
    2180                 2185                 2190             


Gln Arg  Gly Ile Ala Ala Cys  Met Thr Cys Gly Asn  Thr Lys Val 
    2195                 2200                 2205             


Leu Arg  Ala Val His Ser Leu  Leu Ser Arg Leu Met  Ser Ile Phe 
    2210                 2215                 2220             


Pro Thr  Glu Pro Ser Thr Ser  Ser Val Ala Ser Lys  Tyr Glu Glu 
    2225                 2230                 2235             


Leu Glu  Cys Leu Tyr Ala Ala  Val Gly Lys Val Ile  Tyr Glu Gly 
    2240                 2245                 2250             


Leu Thr  Asn Tyr Glu Lys Ala  Thr Asn Ala Asn Pro  Ser Gln Leu 
    2255                 2260                 2265             


Phe Gly  Thr Leu Met Ile Leu  Lys Ser Ala Cys Ser  Asn Asn Pro 
    2270                 2275                 2280             


Ser Tyr  Ile Asp Arg Leu Ile  Ser Val Phe Met Arg  Ser Leu Gln 
    2285                 2290                 2295             


Lys Met  Val Arg Glu His Leu  Asn Pro Gln Ala Ala  Ser Gly Ser 
    2300                 2305                 2310             


Thr Glu  Ala Thr Ser Gly Thr  Ser Glu Leu Val Met  Leu Ser Leu 
    2315                 2320                 2325             


Glu Leu  Val Lys Thr Arg Leu  Ala Val Met Ser Met  Glu Met Arg 
    2330                 2335                 2340             


Lys Asn  Phe Ile Gln Ala Ile  Leu Thr Ser Leu Ile  Glu Lys Ser 
    2345                 2350                 2355             


Pro Asp  Ala Lys Ile Leu Arg  Ala Val Val Lys Ile  Val Glu Glu 
    2360                 2365                 2370             


Trp Val  Lys Asn Asn Ser Pro  Met Ala Ala Asn Gln  Thr Pro Thr 
    2375                 2380                 2385             


Leu Arg  Glu Lys Ser Ile Leu  Leu Val Lys Met Met  Thr Tyr Ile 
    2390                 2395                 2400             


Glu Lys  Arg Phe Pro Glu Asp  Leu Glu Leu Asn Ala  Gln Phe Leu 
    2405                 2410                 2415             


Asp Leu  Val Asn Tyr Val Tyr  Arg Asp Glu Thr Leu  Ser Gly Ser 
    2420                 2425                 2430             


Glu Leu  Thr Ala Lys Leu Glu  Pro Ala Phe Leu Ser  Gly Leu Arg 
    2435                 2440                 2445             


Cys Ala  Gln Pro Leu Ile Arg  Ala Lys Phe Phe Glu  Val Phe Asp 
    2450                 2455                 2460             


Asn Ser  Met Lys Arg Arg Val  Tyr Glu Arg Leu Leu  Tyr Val Thr 
    2465                 2470                 2475             


Cys Ser  Gln Asn Trp Glu Ala  Met Gly Asn His Phe  Trp Ile Lys 
    2480                 2485                 2490             


Gln Cys  Ile Glu Leu Leu Leu  Ala Val Cys Glu Lys  Ser Thr Pro 
    2495                 2500                 2505             


Ile Gly  Thr Ser Cys Gln Gly  Ala Met Leu Pro Ser  Ile Thr Asn 
    2510                 2515                 2520             


Val Ile  Asn Leu Ala Asp Ser  His Asp Arg Ala Ala  Phe Ala Met 
    2525                 2530                 2535             


Val Thr  His Val Lys Gln Glu  Pro Arg Glu Arg Glu  Asn Ser Glu 
    2540                 2545                 2550             


Ser Lys  Glu Glu Asp Val Glu  Ile Asp Ile Glu Leu  Ala Pro Gly 
    2555                 2560                 2565             


Asp Gln  Thr Ser Thr Pro Lys  Thr Lys Glu Leu Ser  Glu Lys Asp 
    2570                 2575                 2580             


Ile Gly  Asn Gln Leu His Met  Leu Thr Asn Arg His  Asp Lys Phe 
    2585                 2590                 2595             


Leu Asp  Thr Leu Arg Glu Val  Lys Thr Gly Ala Leu  Leu Ser Ala 
    2600                 2605                 2610             


Phe Val  Gln Leu Cys His Ile  Ser Thr Thr Leu Ala  Glu Lys Thr 
    2615                 2620                 2625             


Trp Val  Gln Leu Phe Pro Arg  Leu Trp Lys Ile Leu  Ser Asp Arg 
    2630                 2635                 2640             


Gln Gln  His Ala Leu Ala Gly  Glu Ile Ser Pro Phe  Leu Cys Ser 
    2645                 2650                 2655             


Gly Ser  His Gln Val Gln Arg  Asp Cys Gln Pro Ser  Ala Leu Asn 
    2660                 2665                 2670             


Cys Phe  Val Glu Ala Met Ser  Gln Cys Val Pro Pro  Ile Pro Ile 
    2675                 2680                 2685             


Arg Pro  Cys Val Leu Lys Tyr  Leu Gly Lys Thr His  Asn Leu Trp 
    2690                 2695                 2700             


Phe Arg  Ser Thr Leu Met Leu  Glu His Gln Ala Phe  Glu Lys Gly 
    2705                 2710                 2715             


Leu Ser  Leu Gln Ile Lys Pro  Lys Gln Thr Thr Glu  Phe Tyr Glu 
    2720                 2725                 2730             


Gln Glu  Ser Ile Thr Pro Pro  Gln Gln Glu Ile Leu  Asp Ser Leu 
    2735                 2740                 2745             


Ala Glu  Leu Tyr Ser Leu Leu  Gln Glu Glu Asp Met  Trp Ala Gly 
    2750                 2755                 2760             


Leu Trp  Gln Lys Arg Cys Lys  Tyr Ser Glu Thr Ala  Thr Ala Ile 
    2765                 2770                 2775             


Ala Tyr  Glu Gln His Gly Phe  Phe Glu Gln Ala Gln  Glu Ser Tyr 
    2780                 2785                 2790             


Glu Lys  Ala Met Asp Lys Ala  Lys Lys Glu His Glu  Arg Ser Asn 
    2795                 2800                 2805             


Ala Ser  Pro Ala Ile Phe Pro  Glu Tyr Gln Leu Trp  Glu Asp His 
    2810                 2815                 2820             


Trp Ile  Arg Cys Ser Lys Glu  Leu Asn Gln Trp Glu  Ala Leu Thr 
    2825                 2830                 2835             


Glu Tyr  Gly Gln Ser Lys Gly  His Ile Asn Pro Tyr  Leu Val Leu 
    2840                 2845                 2850             


Glu Cys  Ala Trp Arg Val Ser  Asn Trp Thr Ala Met  Lys Glu Ala 
    2855                 2860                 2865             


Leu Val  Gln Val Glu Val Ser  Cys Pro Lys Glu Met  Ala Trp Lys 
    2870                 2875                 2880             


Val Asn  Met Tyr Arg Gly Tyr  Leu Ala Ile Cys His  Pro Glu Glu 
    2885                 2890                 2895             


Gln Gln  Leu Ser Phe Ile Glu  Arg Leu Val Glu Met  Ala Ser Ser 
    2900                 2905                 2910             


Leu Ala  Ile Arg Glu Trp Arg  Arg Leu Pro His Val  Val Ser His 
    2915                 2920                 2925             


Val His  Thr Pro Leu Leu Gln  Ala Ala Gln Gln Ile  Ile Glu Leu 
    2930                 2935                 2940             


Gln Glu  Ala Ala Gln Ile Asn  Ala Gly Leu Gln Pro  Thr Asn Leu 
    2945                 2950                 2955             


Gly Arg  Asn Asn Ser Leu His  Asp Met Lys Thr Val  Val Lys Thr 
    2960                 2965                 2970             


Trp Arg  Asn Arg Leu Pro Ile  Val Ser Asp Asp Leu  Ser His Trp 
    2975                 2980                 2985             


Ser Ser  Ile Phe Met Trp Arg  Gln His His Tyr Gln  Gly Lys Pro 
    2990                 2995                 3000             


Thr Trp  Ser Gly Met His Ser  Ser Ser Ile Val Thr  Ala Tyr Glu 
    3005                 3010                 3015             


Asn Ser  Ser Gln His Asp Pro  Ser Ser Asn Asn Ala  Met Leu Gly 
    3020                 3025                 3030             


Val His  Ala Ser Ala Ser Ala  Ile Ile Gln Tyr Gly  Lys Ile Ala 
    3035                 3040                 3045             


Arg Lys  Gln Gly Leu Val Asn  Val Ala Leu Asp Ile  Leu Ser Arg 
    3050                 3055                 3060             


Ile His  Thr Ile Pro Thr Val  Pro Ile Val Asp Cys  Phe Gln Lys 
    3065                 3070                 3075             


Ile Arg  Gln Gln Val Lys Cys  Tyr Leu Gln Leu Ala  Gly Val Met 
    3080                 3085                 3090             


Gly Lys  Asn Glu Cys Met Gln  Gly Leu Glu Val Ile  Glu Ser Thr 
    3095                 3100                 3105             


Asn Leu  Lys Tyr Phe Thr Lys  Glu Met Thr Ala Glu  Phe Tyr Ala 
    3110                 3115                 3120             


Leu Lys  Gly Met Phe Leu Ala  Gln Ile Asn Lys Ser  Glu Glu Ala 
    3125                 3130                 3135             


Asn Lys  Ala Phe Ser Ala Ala  Val Gln Met His Asp  Val Leu Val 
    3140                 3145                 3150             


Lys Ala  Trp Ala Met Trp Gly  Asp Tyr Leu Glu Asn  Ile Phe Val 
    3155                 3160                 3165             


Lys Glu  Arg Gln Leu His Leu  Gly Val Ser Ala Ile  Thr Cys Tyr 
    3170                 3175                 3180             


Leu His  Ala Cys Arg His Gln  Asn Glu Ser Lys Ser  Arg Lys Tyr 
    3185                 3190                 3195             


Leu Ala  Lys Val Leu Trp Leu  Leu Ser Phe Asp Asp  Asp Lys Asn 
    3200                 3205                 3210             


Thr Leu  Ala Asp Ala Val Asp  Lys Tyr Cys Ile Gly  Val Pro Pro 
    3215                 3220                 3225             


Ile Gln  Trp Leu Ala Trp Ile  Pro Gln Leu Leu Thr  Cys Leu Val 
    3230                 3235                 3240             


Gly Ser  Glu Gly Lys Leu Leu  Leu Asn Leu Ile Ser  Gln Val Gly 
    3245                 3250                 3255             


Arg Val  Tyr Pro Gln Ala Val  Tyr Phe Pro Ile Arg  Thr Leu Tyr 
    3260                 3265                 3270             


Leu Thr  Leu Lys Ile Glu Gln  Arg Glu Arg Tyr Lys  Ser Asp Pro 
    3275                 3280                 3285             


Gly Pro  Ile Arg Ala Thr Ala  Pro Met Trp Arg Cys  Ser Arg Ile 
    3290                 3295                 3300             


Met His  Met Gln Arg Glu Leu  His Pro Thr Leu Leu  Ser Ser Leu 
    3305                 3310                 3315             


Glu Gly  Ile Val Asp Gln Met  Val Trp Phe Arg Glu  Asn Trp His 
    3320                 3325                 3330             


Glu Glu  Val Leu Arg Gln Leu  Gln Gln Gly Leu Ala  Lys Cys Tyr 
    3335                 3340                 3345             


Ser Val  Ala Phe Glu Lys Ser  Gly Ala Val Ser Asp  Ala Lys Ile 
    3350                 3355                 3360             


Thr Pro  His Thr Leu Asn Phe  Val Lys Lys Leu Val  Ser Thr Phe 
    3365                 3370                 3375             


Gly Val  Gly Leu Glu Asn Val  Ser Asn Val Ser Thr  Met Phe Ser 
    3380                 3385                 3390             


Ser Ala  Ala Ser Glu Ser Leu  Ala Arg Arg Ala Gln  Ala Thr Ala 
    3395                 3400                 3405             


Gln Asp  Pro Val Phe Gln Lys  Leu Lys Gly Gln Phe  Thr Thr Asp 
    3410                 3415                 3420             


Phe Asp  Phe Ser Val Pro Gly  Ser Met Lys Leu His  Asn Leu Ile 
    3425                 3430                 3435             


Ser Lys  Leu Lys Lys Trp Ile  Lys Ile Leu Glu Ala  Lys Thr Lys 
    3440                 3445                 3450             


Gln Leu  Pro Lys Phe Phe Leu  Ile Glu Glu Lys Cys  Arg Phe Leu 
    3455                 3460                 3465             


Ser Asn  Phe Ser Ala Gln Thr  Ala Glu Val Glu Ile  Pro Gly Glu 
    3470                 3475                 3480             


Phe Leu  Met Pro Lys Pro Thr  His Tyr Tyr Ile Lys  Ile Ala Arg 
    3485                 3490                 3495             


Phe Met  Pro Arg Val Glu Ile  Val Gln Lys His Asn  Thr Ala Ala 
    3500                 3505                 3510             


Arg Arg  Leu Tyr Ile Arg Gly  His Asn Gly Lys Ile  Tyr Pro Tyr 
    3515                 3520                 3525             


Leu Val  Met Asn Asp Ala Cys  Leu Thr Glu Ser Arg  Arg Glu Glu 
    3530                 3535                 3540             


Arg Val  Leu Gln Leu Leu Arg  Leu Leu Asn Pro Cys  Leu Glu Lys 
    3545                 3550                 3555             


Arg Lys  Glu Thr Thr Lys Arg  His Leu Phe Phe Thr  Val Pro Arg 
    3560                 3565                 3570             


Val Val  Ala Val Ser Pro Gln  Met Arg Leu Val Glu  Asp Asn Pro 
    3575                 3580                 3585             


Ser Ser  Leu Ser Leu Val Glu  Ile Tyr Lys Gln Arg  Cys Ala Lys 
    3590                 3595                 3600             


Lys Gly  Ile Glu His Asp Asn  Pro Ile Ser Arg Tyr  Tyr Asp Arg 
    3605                 3610                 3615             


Leu Ala  Thr Val Gln Ala Arg  Gly Thr Gln Ala Ser  His Gln Val 
    3620                 3625                 3630             


Leu Arg  Asp Ile Leu Lys Glu  Val Gln Ser Asn Met  Val Pro Arg 
    3635                 3640                 3645             


Ser Met  Leu Lys Glu Trp Ala  Leu His Thr Phe Pro  Asn Ala Thr 
    3650                 3655                 3660             


Asp Tyr  Trp Thr Phe Arg Lys  Met Phe Thr Ile Gln  Leu Ala Leu 
    3665                 3670                 3675             


Ile Gly  Phe Ala Glu Phe Val  Leu His Leu Asn Arg  Leu Asn Pro 
    3680                 3685                 3690             


Glu Met  Leu Gln Ile Ala Gln  Asp Thr Gly Lys Leu  Asn Val Ala 
    3695                 3700                 3705             


Tyr Phe  Arg Phe Asp Ile Asn  Asp Ala Thr Gly Asp  Leu Asp Ala 
    3710                 3715                 3720             


Asn Arg  Pro Val Pro Phe Arg  Leu Thr Pro Asn Ile  Ser Glu Phe 
    3725                 3730                 3735             


Leu Thr  Thr Ile Gly Val Ser  Gly Pro Leu Thr Ala  Ser Met Ile 
    3740                 3745                 3750             


Ala Val  Ala Arg Cys Phe Ala  Gln Pro Asn Phe Lys  Val Asp Gly 
    3755                 3760                 3765             


Ile Leu  Lys Thr Val Leu Arg  Asp Glu Ile Ile Ala  Trp His Lys 
    3770                 3775                 3780             


Lys Thr  Gln Glu Asp Thr Ser  Ser Pro Leu Ser Ala  Ala Gly Gln 
    3785                 3790                 3795             


Pro Glu  Asn Met Asp Ser Gln  Gln Leu Val Ser Leu  Val Gln Lys 
    3800                 3805                 3810             


Ala Val  Thr Ala Ile Met Thr  Arg Leu His Asn Leu  Ala Gln Phe 
    3815                 3820                 3825             


Glu Gly  Gly Glu Ser Lys Val  Asn Thr Leu Val Ala  Ala Ala Asn 
    3830                 3835                 3840             


Ser Leu  Asp Asn Leu Cys Arg  Met Asp Pro Ala Trp  His Pro Trp 
    3845                 3850                 3855             


Leu 
    


<210>  194
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ala Ala Leu Ser Gly Val Arg Trp Leu Thr Arg Ala Leu Val Ser 
1               5                   10                  15      


Ala Gly Asn Pro Gly Ala Trp Arg Gly Leu Ser Thr Ser Ala Ala Ala 
            20                  25                  30          


His Ala Ala Ser Arg Ser Gln Ala Glu Asp Val Arg Val Glu Gly Ser 
        35                  40                  45              


Phe Pro Val Thr Met Leu Pro Gly Asp Gly Val Gly Pro Glu Leu Met 
    50                  55                  60                  


His Ala Val Lys Glu Val Phe Lys Ala Ala Ala Val Pro Val Glu Phe 
65                  70                  75                  80  


Gln Glu His His Leu Ser Glu Val Gln Asn Met Ala Ser Glu Glu Lys 
                85                  90                  95      


Leu Glu Gln Val Leu Ser Ser Met Lys Glu Asn Lys Val Ala Ile Ile 
            100                 105                 110         


Gly Lys Ile His Thr Pro Met Glu Tyr Lys Gly Glu Leu Ala Ser Tyr 
        115                 120                 125             


Asp Met Arg Leu Arg Arg Lys Leu Asp Leu Phe Ala Asn Val Val His 
    130                 135                 140                 


Val Lys Ser Leu Pro Gly Tyr Met Thr Arg His Asn Asn Leu Asp Leu 
145                 150                 155                 160 


Val Ile Ile Arg Glu Gln Thr Glu Gly Glu Tyr Ser Ser Leu Glu His 
                165                 170                 175     


Glu Ser Ala Arg Gly Val Ile Glu Cys Leu Lys Ile Val Thr Arg Ala 
            180                 185                 190         


Lys Ser Gln Arg Ile Ala Lys Phe Ala Phe Asp Tyr Ala Thr Lys Lys 
        195                 200                 205             


Gly Arg Gly Lys Val Thr Ala Val His Lys Ala Asn Ile Met Lys Leu 
    210                 215                 220                 


Gly Asp Gly Leu Phe Leu Gln Cys Cys Glu Glu Val Ala Glu Leu Tyr 
225                 230                 235                 240 


Pro Lys Ile Lys Phe Glu Thr Met Ile Ile Asp Asn Cys Cys Met Gln 
                245                 250                 255     


Leu Val Gln Asn Pro Tyr Gln Phe Asp Val Leu Val Met Pro Asn Leu 
            260                 265                 270         


Tyr Gly Asn Ile Ile Asp Asn Leu Ala Ala Gly Leu Val Gly Gly Ala 
        275                 280                 285             


Gly Val Val Pro Gly Glu Ser Tyr Ser Ala Glu Tyr Ala Val Phe Glu 
    290                 295                 300                 


Thr Gly Ala Arg His Pro Phe Ala Gln Ala Val Gly Arg Asn Ile Ala 
305                 310                 315                 320 


Asn Pro Thr Ala Met Leu Leu Ser Ala Ser Asn Met Leu Arg His Leu 
                325                 330                 335     


Asn Leu Glu Tyr His Ser Ser Met Ile Ala Asp Ala Val Lys Lys Val 
            340                 345                 350         


Ile Lys Val Gly Lys Val Arg Thr Arg Asp Met Gly Gly Tyr Ser Thr 
        355                 360                 365             


Thr Thr Asp Phe Ile Lys Ser Val Ile Gly His Leu Gln Thr Lys Gly 
    370                 375                 380                 


Ser 
385 


<210>  195
<211>  1499
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val 
1               5                   10                  15      


Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp 
            20                  25                  30          


Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr 
        35                  40                  45              


Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys 
    50                  55                  60                  


Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu 
65                  70                  75                  80  


Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys 
                85                  90                  95      


Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys 
            100                 105                 110         


Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg 
        115                 120                 125             


Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly 
    130                 135                 140                 


Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile 
145                 150                 155                 160 


Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro 
                165                 170                 175     


Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser 
            180                 185                 190         


Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val 
        195                 200                 205             


Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln 
    210                 215                 220                 


Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly 
225                 230                 235                 240 


Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro 
                245                 250                 255     


Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn 
            260                 265                 270         


Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly 
        275                 280                 285             


Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His 
    290                 295                 300                 


Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys 
305                 310                 315                 320 


Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly 
                325                 330                 335     


Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala 
            340                 345                 350         


Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met 
        355                 360                 365             


Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly 
    370                 375                 380                 


Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro 
385                 390                 395                 400 


Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro 
                405                 410                 415     


Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Ala Lys Gly 
            420                 425                 430         


Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro 
        435                 440                 445             


Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Ile Arg 
    450                 455                 460                 


Gly Gln Pro Gly Asp Pro Gly Val Pro Gly Phe Lys Gly Glu Ala Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro 
                485                 490                 495     


Pro Gly Glu Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Val 
            500                 505                 510         


Gly Pro Pro Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
        515                 520                 525             


Phe Pro Gly Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu 
    530                 535                 540                 


Arg Gly Pro Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro 
545                 550                 555                 560 


Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
                565                 570                 575     


Asn Pro Gly Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala 
            580                 585                 590         


Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg 
        595                 600                 605             


Gly Gln Pro Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Gly Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln 
625                 630                 635                 640 


Arg Gly Ala Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val 
                645                 650                 655     


Gly Pro Pro Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly 
            660                 665                 670         


Pro Thr Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu 
        675                 680                 685             


Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val 
    690                 695                 700                 


Gly Pro Leu Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly 
705                 710                 715                 720 


Glu Pro Gly Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly 
                725                 730                 735     


His Gly Pro Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro 
            740                 745                 750         


Gly Asp Thr Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly 
        755                 760                 765             


Ile Ala Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu 
    770                 775                 780                 


Lys Gly Ala Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro 
785                 790                 795                 800 


Gly Pro Leu Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly 
                805                 810                 815     


Glu Pro Gly Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn 
            820                 825                 830         


Pro Gly Ser Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala 
        835                 840                 845             


Gly Pro Gln Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly 
    850                 855                 860                 


Glu Pro Gly Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu 
865                 870                 875                 880 


Ala Gly Ser Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys 
                885                 890                 895     


Gly Gly Arg Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly 
            900                 905                 910         


Ser Ala Gly Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro 
        915                 920                 925             


Ala Gly Pro Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg 
    930                 935                 940                 


Gly Asp Pro Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln 
                965                 970                 975     


Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg 
            980                 985                 990         


Gly Ile Val Gly Met Pro Gly Gln  Arg Gly Glu Arg Gly  Met Pro Gly 
        995                 1000                 1005             


Leu Pro  Gly Pro Ala Gly Thr  Pro Gly Lys Val Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Thr  Gly Asp Lys Gly Pro  Pro Gly Pro Val Gly  Pro Pro Gly 
    1025                 1030                 1035             


Ser Asn  Gly Pro Val Gly Glu  Pro Gly Pro Glu Gly  Pro Ala Gly 
    1040                 1045                 1050             


Asn Asp  Gly Thr Pro Gly Arg  Asp Gly Ala Val Gly  Glu Arg Gly 
    1055                 1060                 1065             


Asp Arg  Gly Asp Pro Gly Pro  Ala Gly Leu Pro Gly  Ser Gln Gly 
    1070                 1075                 1080             


Ala Pro  Gly Thr Pro Gly Pro  Val Gly Ala Pro Gly  Asp Ala Gly 
    1085                 1090                 1095             


Gln Arg  Gly Asp Pro Gly Ser  Arg Gly Pro Ile Gly  Pro Pro Gly 
    1100                 1105                 1110             


Arg Ala  Gly Lys Arg Gly Leu  Pro Gly Pro Gln Gly  Pro Arg Gly 
    1115                 1120                 1125             


Asp Lys  Gly Asp His Gly Asp  Arg Gly Asp Arg Gly  Gln Lys Gly 
    1130                 1135                 1140             


His Arg  Gly Phe Thr Gly Leu  Gln Gly Leu Pro Gly  Pro Pro Gly 
    1145                 1150                 1155             


Pro Asn  Gly Glu Gln Gly Ser  Ala Gly Ile Pro Gly  Pro Phe Gly 
    1160                 1165                 1170             


Pro Arg  Gly Pro Pro Gly Pro  Val Gly Pro Ser Gly  Lys Glu Gly 
    1175                 1180                 1185             


Asn Pro  Gly Pro Leu Gly Pro  Ile Gly Pro Pro Gly  Val Arg Gly 
    1190                 1195                 1200             


Ser Val  Gly Glu Ala Gly Pro  Glu Gly Pro Pro Gly  Glu Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly His Leu Thr  Ala Ala Leu 
    1220                 1225                 1230             


Gly Asp  Ile Met Gly His Tyr  Asp Glu Ser Met Pro  Asp Pro Leu 
    1235                 1240                 1245             


Pro Glu  Phe Thr Glu Asp Gln  Ala Ala Pro Asp Asp  Lys Asn Lys 
    1250                 1255                 1260             


Thr Asp  Pro Gly Val His Ala  Thr Leu Lys Ser Leu  Ser Ser Gln 
    1265                 1270                 1275             


Ile Glu  Thr Met Arg Ser Pro  Asp Gly Ser Lys Lys  His Pro Ala 
    1280                 1285                 1290             


Arg Thr  Cys Asp Asp Leu Lys  Leu Cys His Ser Ala  Lys Gln Ser 
    1295                 1300                 1305             


Gly Glu  Tyr Trp Ile Asp Pro  Asn Gln Gly Ser Val  Glu Asp Ala 
    1310                 1315                 1320             


Ile Lys  Val Tyr Cys Asn Met  Glu Thr Gly Glu Thr  Cys Ile Ser 
    1325                 1330                 1335             


Ala Asn  Pro Ser Ser Val Pro  Arg Lys Thr Trp Trp  Ala Ser Lys 
    1340                 1345                 1350             


Ser Pro  Asp Asn Lys Pro Val  Trp Tyr Gly Leu Asp  Met Asn Arg 
    1355                 1360                 1365             


Gly Ser  Gln Phe Ala Tyr Gly  Asp His Gln Ser Pro  Asn Thr Ala 
    1370                 1375                 1380             


Ile Thr  Gln Met Thr Phe Leu  Arg Leu Leu Ser Lys  Glu Ala Ser 
    1385                 1390                 1395             


Gln Asn  Ile Thr Tyr Ile Cys  Lys Asn Ser Val Gly  Tyr Met Asp 
    1400                 1405                 1410             


Asp Gln  Ala Lys Asn Leu Lys  Lys Ala Val Val Leu  Lys Gly Ala 
    1415                 1420                 1425             


Asn Asp  Leu Asp Ile Lys Ala  Glu Gly Asn Ile Arg  Phe Arg Tyr 
    1430                 1435                 1440             


Ile Val  Leu Gln Asp Thr Cys  Ser Lys Arg Asn Gly  Asn Val Gly 
    1445                 1450                 1455             


Lys Thr  Val Phe Glu Tyr Arg  Thr Gln Asn Val Ala  Arg Leu Pro 
    1460                 1465                 1470             


Ile Ile  Asp Leu Ala Pro Val  Asp Val Gly Gly Thr  Asp Gln Glu 
    1475                 1480                 1485             


Phe Gly  Val Glu Ile Gly Pro  Val Cys Phe Val 
    1490                 1495                 


<210>  196
<211>  4857
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Val Thr Gly Gly Gly Ala Ala Pro Pro Gly Thr Val Thr Glu Pro 
1               5                   10                  15      


Leu Pro Ser Val Ile Val Leu Ser Ala Gly Arg Lys Met Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala Ala Gly Ala Gly 
        35                  40                  45              


Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp Gly Cys Met His 
    50                  55                  60                  


Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His Pro Ala Leu Asn 
65                  70                  75                  80  


Ala Ile Leu Ala Val Thr Ser Arg Gly Thr Ile Lys Val Ile Asp Gly 
                85                  90                  95      


Thr Ser Gly Ala Thr Leu Gln Ala Ser Ala Leu Ser Ala Lys Pro Gly 
            100                 105                 110         


Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp Lys Val Ile Phe 
        115                 120                 125             


Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu Asn Gly Ile Leu 
    130                 135                 140                 


Leu Leu Asp Thr Ala Leu Gln Thr Pro Val Ser Lys Gln Asp Asp Val 
145                 150                 155                 160 


Val Gln Leu Glu Leu Pro Val Thr Glu Ala Gln Gln Leu Leu Ser Ala 
                165                 170                 175     


Cys Leu Glu Lys Val Asp Ile Ser Ser Thr Glu Gly Tyr Asp Leu Phe 
            180                 185                 190         


Ile Thr Gln Leu Lys Asp Gly Leu Lys Asn Thr Ser His Glu Thr Ala 
        195                 200                 205             


Ala Asn His Lys Val Ala Lys Trp Ala Thr Val Thr Phe His Leu Pro 
    210                 215                 220                 


His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val Asn Glu Leu Lys 
225                 230                 235                 240 


Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala Ser Ser Val Met 
                245                 250                 255     


Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro Glu Leu Gly Val 
            260                 265                 270         


Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr Ser Glu Ala Asn 
        275                 280                 285             


Arg Arg Glu Thr Phe Thr Ser Trp Pro His Val Gly Tyr Arg Trp Ala 
    290                 295                 300                 


Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His Gln Pro Ala Ser 
305                 310                 315                 320 


Ser Gly Asp Asp Arg Ala Met Cys Phe Thr Cys Ser Val Cys Leu Val 
                325                 330                 335     


Cys Trp Glu Pro Thr Asp Glu Pro Trp Ser Glu His Glu Arg His Ser 
            340                 345                 350         


Pro Asn Cys Pro Phe Val Lys Gly Glu His Thr Gln Asn Val Pro Leu 
        355                 360                 365             


Ser Val Thr Leu Ala Thr Ser Pro Ala Gln Phe Pro Cys Thr Asp Gly 
    370                 375                 380                 


Thr Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys Pro His Phe Leu 
385                 390                 395                 400 


Ala Ala Ala Thr Lys Arg Gly Lys Ile Cys Ile Trp Asp Val Ser Lys 
                405                 410                 415     


Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala Tyr Asp Pro Ala 
            420                 425                 430         


Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser Ser Gly Val Asp 
        435                 440                 445             


Ser Arg Arg Pro Thr Leu Ala Trp Leu Glu Asp Ser Ser Ser Cys Ser 
    450                 455                 460                 


Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu Leu Glu Asp Ser 
465                 470                 475                 480 


Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Thr Gly His Thr Ser 
                485                 490                 495     


Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Thr Ala Leu Ser Ile 
            500                 505                 510         


Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val Ala Asn Val Leu 
        515                 520                 525             


Glu Asp Thr Val Lys Asp Leu Glu Glu Leu Gly Ala Asn Pro Cys Leu 
    530                 535                 540                 


Thr Asn Ser Lys Ser Glu Lys Thr Lys Glu Lys His Gln Glu Gln His 
545                 550                 555                 560 


Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu Leu Thr Tyr Lys 
                565                 570                 575     


Ser Pro Ala Thr Ser Pro Ile Ser Ser Asn Ser His Arg Ser Leu Asp 
            580                 585                 590         


Gly Leu Ser Arg Thr Gln Gly Glu Ser Ile Ser Glu Gln Gly Ser Thr 
        595                 600                 605             


Asp Asn Glu Ser Cys Thr Asn Ser Glu Leu Asn Ser Pro Leu Val Arg 
    610                 615                 620                 


Arg Thr Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys Glu Ser Asp Glu 
625                 630                 635                 640 


Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile Met Ser Lys Ser 
                645                 650                 655     


Leu His Asp Asp Gly Phe Thr Val Pro Gln Ile Ile Glu Met Glu Leu 
            660                 665                 670         


Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro Val Thr Tyr Ile 
        675                 680                 685             


Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Thr Ser Pro Asp Ser Glu 
    690                 695                 700                 


Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Thr Leu Val Gln Cys Leu 
705                 710                 715                 720 


Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys Ile Asp Ser Ile 
                725                 730                 735     


Thr Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly Leu Arg Thr Cys 
            740                 745                 750         


Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu Ala Leu Asn Asn 
        755                 760                 765             


Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg Lys Gly Glu Leu 
    770                 775                 780                 


Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile Ser Val Ile Gln 
785                 790                 795                 800 


His Glu Ser Pro Ala Asp Val Gln Thr Pro Leu Ile Ile Gln Pro Glu 
                805                 810                 815     


Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr Lys Met Asn Tyr 
            820                 825                 830         


Ala Thr Arg Ile Val Thr Leu Glu Glu Glu Pro Ile Lys Ile Gln His 
        835                 840                 845             


Ile Lys Asp Pro Gln Asp Thr Ile Thr Ser Leu Ile Leu Leu Pro Pro 
    850                 855                 860                 


Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu Pro Ile Glu Asp 
865                 870                 875                 880 


Met Gln Leu Thr Ser Lys Asn Gly Phe Glu Arg Glu Lys Thr Ser Asp 
                885                 890                 895     


Ile Ser Thr Leu Gly His Leu Val Ile Thr Thr Gln Gly Gly Tyr Val 
            900                 905                 910         


Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala Lys Val Glu Pro 
        915                 920                 925             


Pro Lys Lys Glu Gly Thr Glu Glu Gln Asp Thr Phe Val Ser Val Ile 
    930                 935                 940                 


Tyr Cys Ser Gly Thr Asp Arg Leu Cys Ala Cys Thr Lys Gly Gly Glu 
945                 950                 955                 960 


Leu His Phe Leu Gln Ile Gly Gly Thr Cys Asp Asp Ile Asp Glu Ala 
                965                 970                 975     


Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile Glu Pro Ser Ser 
            980                 985                 990         


Glu Gly Ser Lys Pro Leu Ser Asn  Pro Ser Ser Pro Gly  Ile Ser Gly 
        995                 1000                 1005             


Val Asp  Leu Leu Val Asp Gln  Pro Phe Thr Leu Glu  Ile Leu Thr 
    1010                 1015                 1020             


Ser Leu  Val Glu Leu Thr Arg  Phe Glu Thr Leu Thr  Pro Arg Phe 
    1025                 1030                 1035             


Ser Ala  Thr Val Pro Pro Cys  Trp Val Glu Val Gln  Gln Glu Gln 
    1040                 1045                 1050             


Gln Gln  Arg Arg His Pro Gln  His Leu His Gln Gln  His His Gly 
    1055                 1060                 1065             


Asp Ala  Ala Gln His Thr Arg  Thr Trp Lys Leu Gln  Thr Asp Ser 
    1070                 1075                 1080             


Asn Ser  Trp Asp Glu His Val  Phe Glu Leu Val Leu  Pro Lys Ala 
    1085                 1090                 1095             


Cys Met  Val Gly His Val Asp  Phe Lys Phe Val Leu  Asn Ser Asn 
    1100                 1105                 1110             


Ile Thr  Asn Ile Pro Gln Ile  Gln Val Thr Leu Leu  Lys Asn Lys 
    1115                 1120                 1125             


Ala Pro  Gly Leu Gly Lys Val  Asn Ala Leu Asn Ile  Glu Val Glu 
    1130                 1135                 1140             


Gln Asn  Gly Lys Pro Ser Leu  Val Asp Leu Asn Glu  Glu Met Gln 
    1145                 1150                 1155             


His Met  Asp Val Glu Glu Ser  Gln Cys Leu Arg Leu  Cys Pro Phe 
    1160                 1165                 1170             


Leu Glu  Asp His Lys Glu Asp  Ile Leu Cys Gly Pro  Val Trp Leu 
    1175                 1180                 1185             


Ala Ser  Gly Leu Asp Leu Ser  Gly His Ala Gly Met  Leu Thr Leu 
    1190                 1195                 1200             


Thr Ser  Pro Lys Leu Val Lys  Gly Met Ala Gly Gly  Lys Tyr Arg 
    1205                 1210                 1215             


Ser Phe  Leu Ile His Val Lys  Ala Val Asn Glu Arg  Gly Thr Glu 
    1220                 1225                 1230             


Glu Ile  Cys Asn Gly Gly Met  Arg Pro Val Val Arg  Leu Pro Ser 
    1235                 1240                 1245             


Leu Lys  His Gln Ser Asn Lys  Gly Tyr Ser Leu Ala  Ser Leu Leu 
    1250                 1255                 1260             


Ala Lys  Val Ala Ala Gly Lys  Glu Lys Ser Ser Asn  Val Lys Asn 
    1265                 1270                 1275             


Glu Asn  Thr Ser Gly Thr Arg  Lys Ser Glu Asn Leu  Arg Gly Cys 
    1280                 1285                 1290             


Asp Leu  Leu Gln Glu Val Ser  Val Thr Ile Arg Arg  Phe Lys Lys 
    1295                 1300                 1305             


Thr Ser  Ile Ser Lys Glu Arg  Val Gln Arg Cys Ala  Met Leu Gln 
    1310                 1315                 1320             


Phe Ser  Glu Phe His Glu Lys  Leu Val Asn Thr Leu  Cys Arg Lys 
    1325                 1330                 1335             


Thr Asp  Asp Gly Gln Ile Thr  Glu His Ala Gln Ser  Leu Val Leu 
    1340                 1345                 1350             


Asp Thr  Leu Cys Trp Leu Ala  Gly Val His Ser Asn  Gly Pro Gly 
    1355                 1360                 1365             


Ser Ser  Lys Glu Gly Asn Glu  Asn Leu Leu Ser Lys  Thr Arg Lys 
    1370                 1375                 1380             


Phe Leu  Ser Asp Ile Val Arg  Val Cys Phe Phe Glu  Ala Gly Arg 
    1385                 1390                 1395             


Ser Ile  Ala His Lys Cys Ala  Arg Phe Leu Ala Leu  Cys Ile Ser 
    1400                 1405                 1410             


Asn Gly  Lys Cys Asp Pro Cys  Gln Pro Ala Phe Gly  Pro Val Leu 
    1415                 1420                 1425             


Leu Lys  Ala Leu Leu Asp Asn  Met Ser Phe Leu Pro  Ala Ala Thr 
    1430                 1435                 1440             


Thr Gly  Gly Ser Val Tyr Trp  Tyr Phe Val Leu Leu  Asn Tyr Val 
    1445                 1450                 1455             


Lys Asp  Glu Asp Leu Ala Gly  Cys Ser Thr Ala Cys  Ala Ser Leu 
    1460                 1465                 1470             


Leu Thr  Ala Val Ser Arg Gln  Leu Gln Asp Arg Leu  Thr Pro Met 
    1475                 1480                 1485             


Glu Ala  Leu Leu Gln Thr Arg  Tyr Gly Leu Tyr Ser  Ser Pro Phe 
    1490                 1495                 1500             


Asp Pro  Val Leu Phe Asp Leu  Glu Met Ser Gly Ser  Ser Cys Lys 
    1505                 1510                 1515             


Asn Val  Tyr Asn Ser Ser Ile  Gly Val Gln Ser Asp  Glu Ile Asp 
    1520                 1525                 1530             


Leu Ser  Asp Val Leu Ser Gly  Asn Gly Lys Val Ser  Ser Cys Thr 
    1535                 1540                 1545             


Ala Ala  Glu Gly Ser Phe Thr  Ser Leu Thr Gly Leu  Leu Glu Val 
    1550                 1555                 1560             


Glu Pro  Leu His Phe Thr Cys  Val Ser Thr Ser Asp  Gly Thr Arg 
    1565                 1570                 1575             


Ile Glu  Arg Asp Asp Ala Met  Ser Ser Phe Gly Val  Thr Pro Ala 
    1580                 1585                 1590             


Val Gly  Gly Leu Ser Ser Gly  Thr Val Gly Glu Ala  Ser Thr Ala 
    1595                 1600                 1605             


Leu Ser  Ser Ala Ala Gln Val  Ala Leu Gln Ser Leu  Ser His Ala 
    1610                 1615                 1620             


Met Ala  Ser Ala Glu Gln Gln  Leu Gln Val Leu Gln  Glu Lys Gln 
    1625                 1630                 1635             


Gln Gln  Leu Leu Lys Leu Gln  Gln Gln Lys Ala Lys  Leu Glu Ala 
    1640                 1645                 1650             


Lys Leu  His Gln Thr Thr Ala  Ala Ala Ala Ala Ala  Ala Ser Ala 
    1655                 1660                 1665             


Val Gly  Pro Val His Asn Ser  Val Pro Ser Asn Pro  Val Ala Ala 
    1670                 1675                 1680             


Pro Gly  Phe Phe Ile His Pro  Ser Asp Val Ile Pro  Pro Thr Pro 
    1685                 1690                 1695             


Lys Thr  Thr Pro Leu Phe Met  Thr Pro Pro Leu Thr  Pro Pro Asn 
    1700                 1705                 1710             


Glu Ala  Val Ser Val Val Ile  Asn Ala Glu Leu Ala  Gln Leu Phe 
    1715                 1720                 1725             


Pro Gly  Ser Val Ile Asp Pro  Pro Ala Val Asn Leu  Ala Ala His 
    1730                 1735                 1740             


Asn Lys  Asn Ser Asn Lys Ser  Arg Met Asn Pro Leu  Gly Ser Gly 
    1745                 1750                 1755             


Leu Ala  Leu Ala Ile Ser His  Ala Ser His Phe Leu  Gln Pro Pro 
    1760                 1765                 1770             


Pro His  Gln Ser Ile Ile Ile  Glu Arg Met His Ser  Gly Ala Arg 
    1775                 1780                 1785             


Arg Phe  Val Thr Leu Asp Phe  Gly Arg Pro Ile Leu  Leu Thr Asp 
    1790                 1795                 1800             


Val Leu  Ile Pro Thr Cys Gly  Asp Leu Ala Ser Leu  Ser Ile Asp 
    1805                 1810                 1815             


Ile Trp  Thr Leu Gly Glu Glu  Val Asp Gly Arg Arg  Leu Val Val 
    1820                 1825                 1830             


Ala Thr  Asp Ile Ser Thr His  Ser Leu Ile Leu His  Asp Leu Ile 
    1835                 1840                 1845             


Pro Pro  Pro Val Cys Arg Phe  Met Lys Ile Thr Val  Ile Gly Arg 
    1850                 1855                 1860             


Tyr Gly  Ser Thr Asn Ala Arg  Ala Lys Ile Pro Leu  Gly Phe Tyr 
    1865                 1870                 1875             


Tyr Gly  His Thr Tyr Ile Leu  Pro Trp Glu Ser Glu  Leu Lys Leu 
    1880                 1885                 1890             


Met His  Asp Pro Leu Lys Gly  Glu Gly Glu Ser Ala  Asn Gln Pro 
    1895                 1900                 1905             


Glu Ile  Asp Gln His Leu Ala  Met Met Val Ala Leu  Gln Glu Asp 
    1910                 1915                 1920             


Ile Gln  Cys Arg Tyr Asn Leu  Ala Cys His Arg Leu  Glu Thr Leu 
    1925                 1930                 1935             


Leu Gln  Ser Ile Asp Leu Pro  Pro Leu Asn Ser Ala  Asn Asn Ala 
    1940                 1945                 1950             


Gln Tyr  Phe Leu Arg Lys Pro  Asp Lys Ala Val Glu  Glu Asp Ser 
    1955                 1960                 1965             


Arg Val  Phe Ser Ala Tyr Gln  Asp Cys Ile Gln Leu  Gln Leu Gln 
    1970                 1975                 1980             


Leu Asn  Leu Ala His Asn Ala  Val Gln Arg Leu Lys  Val Ala Leu 
    1985                 1990                 1995             


Gly Ala  Ser Arg Lys Met Leu  Ser Glu Thr Ser Asn  Pro Glu Asp 
    2000                 2005                 2010             


Leu Ile  Gln Thr Ser Ser Thr  Glu Gln Leu Arg Thr  Ile Ile Arg 
    2015                 2020                 2025             


Tyr Leu  Leu Asp Thr Leu Leu  Ser Leu Leu His Ala  Ser Asn Gly 
    2030                 2035                 2040             


His Ser  Val Pro Ala Val Leu  Gln Ser Thr Phe His  Ala Gln Ala 
    2045                 2050                 2055             


Cys Glu  Glu Leu Phe Lys His  Leu Cys Ile Ser Gly  Thr Pro Lys 
    2060                 2065                 2070             


Ile Arg  Leu His Thr Gly Leu  Leu Leu Val Gln Leu  Cys Gly Gly 
    2075                 2080                 2085             


Glu Arg  Trp Trp Gly Gln Phe  Leu Ser Asn Val Leu  Gln Glu Leu 
    2090                 2095                 2100             


Tyr Asn  Ser Glu Gln Leu Leu  Ile Phe Pro Gln Asp  Arg Val Phe 
    2105                 2110                 2115             


Met Leu  Leu Ser Cys Ile Gly  Gln Arg Ser Leu Ser  Asn Ser Gly 
    2120                 2125                 2130             


Val Leu  Glu Ser Leu Leu Asn  Leu Leu Asp Asn Leu  Leu Ser Pro 
    2135                 2140                 2145             


Leu Gln  Pro Gln Leu Pro Met  His Arg Arg Thr Glu  Gly Val Leu 
    2150                 2155                 2160             


Asp Ile  Pro Met Ile Ser Trp  Val Val Met Leu Val  Ser Arg Leu 
    2165                 2170                 2175             


Leu Asp  Tyr Val Ala Thr Val  Glu Asp Glu Ala Ala  Ala Ala Lys 
    2180                 2185                 2190             


Lys Pro  Leu Asn Gly Asn Gln  Trp Ser Phe Ile Asn  Asn Asn Leu 
    2195                 2200                 2205             


His Thr  Gln Ser Leu Asn Arg  Ser Ser Lys Gly Ser  Ser Ser Leu 
    2210                 2215                 2220             


Asp Arg  Leu Tyr Ser Arg Lys  Ile Arg Lys Gln Leu  Val His His 
    2225                 2230                 2235             


Lys Gln  Gln Leu Asn Leu Leu  Lys Ala Lys Gln Lys  Ala Leu Val 
    2240                 2245                 2250             


Glu Gln  Met Glu Lys Glu Lys  Ile Gln Ser Asn Lys  Gly Ser Ser 
    2255                 2260                 2265             


Tyr Lys  Leu Leu Val Glu Gln  Ala Lys Leu Lys Gln  Ala Thr Ser 
    2270                 2275                 2280             


Lys His  Phe Lys Asp Leu Ile  Arg Leu Arg Arg Thr  Ala Glu Trp 
    2285                 2290                 2295             


Ser Arg  Ser Asn Leu Asp Thr  Glu Val Thr Thr Ala  Lys Glu Ser 
    2300                 2305                 2310             


Pro Glu  Ile Glu Pro Leu Pro  Phe Thr Leu Ala His  Glu Arg Cys 
    2315                 2320                 2325             


Ile Ser  Val Val Gln Lys Leu  Val Leu Phe Leu Leu  Ser Met Asp 
    2330                 2335                 2340             


Phe Thr  Cys His Ala Asp Leu  Leu Leu Phe Val Cys  Lys Val Leu 
    2345                 2350                 2355             


Ala Arg  Ile Ala Asn Ala Thr  Arg Pro Thr Ile His  Leu Cys Glu 
    2360                 2365                 2370             


Ile Val  Asn Glu Pro Gln Leu  Glu Arg Leu Leu Leu  Leu Leu Val 
    2375                 2380                 2385             


Gly Thr  Asp Phe Asn Arg Gly  Asp Ile Ser Trp Gly  Gly Ala Trp 
    2390                 2395                 2400             


Ala Gln  Tyr Ser Leu Thr Cys  Met Leu Gln Asp Ile  Leu Ala Gly 
    2405                 2410                 2415             


Glu Leu  Leu Ala Pro Val Ala  Ala Glu Ala Met Glu  Glu Gly Thr 
    2420                 2425                 2430             


Val Gly  Asp Asp Val Gly Ala  Thr Ala Gly Asp Ser  Asp Asp Ser 
    2435                 2440                 2445             


Leu Gln  Gln Ser Ser Val Gln  Leu Leu Glu Thr Ile  Asp Glu Pro 
    2450                 2455                 2460             


Leu Thr  His Asp Ile Thr Gly  Ala Pro Pro Leu Ser  Ser Leu Glu 
    2465                 2470                 2475             


Lys Asp  Lys Glu Ile Asp Leu  Glu Leu Leu Gln Asp  Leu Met Glu 
    2480                 2485                 2490             


Val Asp  Ile Asp Pro Leu Asp  Ile Asp Leu Glu Lys  Asp Pro Leu 
    2495                 2500                 2505             


Ala Ala  Lys Val Phe Lys Pro  Ile Ser Ser Thr Trp  Tyr Asp Tyr 
    2510                 2515                 2520             


Trp Gly  Ala Asp Tyr Gly Thr  Tyr Asn Tyr Asn Pro  Tyr Ile Gly 
    2525                 2530                 2535             


Gly Leu  Gly Ile Pro Val Ala  Lys Pro Pro Ala Asn  Thr Glu Lys 
    2540                 2545                 2550             


Asn Gly  Ser Gln Thr Val Ser  Val Ser Val Ser Gln  Ala Leu Asp 
    2555                 2560                 2565             


Ala Arg  Leu Glu Val Gly Leu  Glu Gln Gln Ala Glu  Leu Met Leu 
    2570                 2575                 2580             


Lys Met  Met Ser Thr Leu Glu  Ala Asp Ser Ile Leu  Gln Ala Leu 
    2585                 2590                 2595             


Thr Asn  Thr Ser Pro Thr Leu  Ser Gln Ser Pro Thr  Gly Thr Asp 
    2600                 2605                 2610             


Asp Ser  Leu Leu Gly Gly Leu  Gln Ala Ala Asn Gln  Thr Ser Gln 
    2615                 2620                 2625             


Leu Ile  Ile Gln Leu Ser Ser  Val Pro Met Leu Asn  Val Cys Phe 
    2630                 2635                 2640             


Asn Lys  Leu Phe Ser Met Leu  Gln Val His His Val  Gln Leu Glu 
    2645                 2650                 2655             


Ser Leu  Leu Gln Leu Trp Leu  Thr Leu Ser Leu Asn  Ser Ser Ser 
    2660                 2665                 2670             


Thr Gly  Asn Lys Glu Asn Gly  Ala Asp Ile Phe Leu  Tyr Asn Ala 
    2675                 2680                 2685             


Asn Arg  Ile Pro Val Ile Ser  Leu Asn Gln Ala Ser  Ile Thr Ser 
    2690                 2695                 2700             


Phe Leu  Thr Val Leu Ala Trp  Tyr Pro Asn Thr Leu  Leu Arg Thr 
    2705                 2710                 2715             


Trp Cys  Leu Val Leu His Ser  Leu Thr Leu Met Thr  Asn Met Gln 
    2720                 2725                 2730             


Leu Asn  Ser Gly Ser Ser Ser  Ala Ile Gly Thr Gln  Glu Ser Thr 
    2735                 2740                 2745             


Ala His  Leu Leu Val Ser Asp  Pro Asn Leu Ile His  Val Leu Val 
    2750                 2755                 2760             


Lys Phe  Leu Ser Gly Thr Ser  Pro His Gly Thr Asn  Gln His Ser 
    2765                 2770                 2775             


Pro Gln  Val Gly Pro Thr Ala  Thr Gln Ala Met Gln  Glu Phe Leu 
    2780                 2785                 2790             


Thr Arg  Leu Gln Val His Leu  Ser Ser Thr Cys Pro  Gln Ile Phe 
    2795                 2800                 2805             


Ser Glu  Phe Leu Leu Lys Leu  Ile His Ile Leu Ser  Thr Glu Arg 
    2810                 2815                 2820             


Gly Ala  Phe Gln Thr Gly Gln  Gly Pro Leu Asp Ala  Gln Val Lys 
    2825                 2830                 2835             


Leu Leu  Glu Phe Thr Leu Glu  Gln Asn Phe Glu Val  Val Ser Val 
    2840                 2845                 2850             


Ser Thr  Ile Ser Ala Val Ile  Glu Ser Val Thr Phe  Leu Val His 
    2855                 2860                 2865             


His Tyr  Ile Thr Cys Ser Asp  Lys Val Met Ser Arg  Ser Gly Ser 
    2870                 2875                 2880             


Asp Ser  Ser Val Gly Ala Arg  Ala Cys Phe Gly Gly  Leu Phe Ala 
    2885                 2890                 2895             


Asn Leu  Ile Arg Pro Gly Asp  Ala Lys Ala Val Cys  Gly Glu Met 
    2900                 2905                 2910             


Thr Arg  Asp Gln Leu Met Phe  Asp Leu Leu Lys Leu  Val Asn Ile 
    2915                 2920                 2925             


Leu Val  Gln Leu Pro Leu Ser  Gly Asn Arg Glu Tyr  Ser Ala Arg 
    2930                 2935                 2940             


Val Ser  Val Thr Thr Asn Thr  Thr Asp Ser Val Ser  Asp Glu Glu 
    2945                 2950                 2955             


Lys Val  Ser Gly Gly Lys Asp  Gly Asn Gly Ser Ser  Thr Ser Val 
    2960                 2965                 2970             


Gln Gly  Ser Pro Ala Tyr Val  Ala Asp Leu Val Leu  Ala Asn Gln 
    2975                 2980                 2985             


Gln Ile  Met Ser Gln Ile Leu  Ser Ala Leu Gly Leu  Cys Asn Ser 
    2990                 2995                 3000             


Ser Ala  Met Ala Met Ile Ile  Gly Ala Ser Gly Leu  His Leu Thr 
    3005                 3010                 3015             


Lys His  Glu Asn Phe His Gly  Gly Leu Asp Ala Ile  Ser Val Gly 
    3020                 3025                 3030             


Asp Gly  Leu Phe Thr Ile Leu  Thr Thr Leu Ser Lys  Lys Ala Ser 
    3035                 3040                 3045             


Thr Val  His Met Met Leu Gln  Pro Ile Leu Thr Tyr  Met Ala Cys 
    3050                 3055                 3060             


Gly Tyr  Met Gly Arg Gln Gly  Ser Leu Ala Thr Cys  Gln Leu Ser 
    3065                 3070                 3075             


Glu Pro  Leu Leu Trp Phe Ile  Leu Arg Val Leu Asp  Thr Ser Asp 
    3080                 3085                 3090             


Ala Leu  Lys Ala Phe His Asp  Met Gly Gly Val Gln  Leu Ile Cys 
    3095                 3100                 3105             


Asn Asn  Met Val Thr Ser Thr  Arg Ala Ile Val Asn  Thr Ala Arg 
    3110                 3115                 3120             


Ser Met  Val Ser Thr Ile Met  Lys Phe Leu Asp Ser  Gly Pro Asn 
    3125                 3130                 3135             


Lys Ala  Val Asp Ser Thr Leu  Lys Thr Arg Ile Leu  Ala Ser Glu 
    3140                 3145                 3150             


Pro Asp  Asn Ala Glu Gly Ile  His Asn Phe Ala Pro  Leu Gly Thr 
    3155                 3160                 3165             


Ile Thr  Ser Ser Ser Pro Thr  Ala Gln Pro Ala Glu  Val Leu Leu 
    3170                 3175                 3180             


Gln Ala  Thr Pro Pro His Arg  Arg Ala Arg Ser Ala  Ala Trp Ser 
    3185                 3190                 3195             


Tyr Ile  Phe Leu Pro Glu Glu  Ala Trp Cys Asp Leu  Thr Ile His 
    3200                 3205                 3210             


Leu Pro  Ala Ala Val Leu Leu  Lys Glu Ile His Ile  Gln Pro His 
    3215                 3220                 3225             


Leu Ala  Ser Leu Ala Thr Cys  Pro Ser Ser Val Ser  Val Glu Val 
    3230                 3235                 3240             


Ser Ala  Asp Gly Val Asn Met  Leu Pro Leu Ser Thr  Pro Val Val 
    3245                 3250                 3255             


Thr Ser  Gly Leu Thr Tyr Ile  Lys Ile Gln Leu Val  Lys Ala Glu 
    3260                 3265                 3270             


Val Ala  Ser Ala Val Cys Leu  Arg Leu His Arg Pro  Arg Asp Ala 
    3275                 3280                 3285             


Ser Thr  Leu Gly Leu Ser Gln  Ile Lys Leu Leu Gly  Leu Thr Ala 
    3290                 3295                 3300             


Phe Gly  Thr Thr Ser Ser Ala  Thr Val Asn Asn Pro  Phe Leu Pro 
    3305                 3310                 3315             


Ser Glu  Asp Gln Val Ser Lys  Thr Ser Ile Gly Trp  Leu Arg Leu 
    3320                 3325                 3330             


Leu His  His Cys Leu Thr His  Ile Ser Asp Leu Glu  Gly Met Met 
    3335                 3340                 3345             


Ala Ser  Ala Ala Ala Pro Thr  Ala Asn Leu Leu Gln  Thr Cys Ala 
    3350                 3355                 3360             


Ala Leu  Leu Met Ser Pro Tyr  Cys Gly Met His Ser  Pro Asn Ile 
    3365                 3370                 3375             


Glu Val  Val Leu Val Lys Ile  Gly Leu Gln Ser Thr  Arg Ile Gly 
    3380                 3385                 3390             


Leu Lys  Leu Ile Asp Ile Leu  Leu Arg Asn Cys Ala  Ala Ser Gly 
    3395                 3400                 3405             


Ser Asp  Pro Thr Asp Leu Asn  Ser Pro Leu Leu Phe  Gly Arg Leu 
    3410                 3415                 3420             


Asn Gly  Leu Ser Ser Asp Ser  Thr Ile Asp Ile Leu  Tyr Gln Leu 
    3425                 3430                 3435             


Gly Thr  Thr Gln Asp Pro Gly  Thr Lys Asp Arg Ile  Gln Ala Leu 
    3440                 3445                 3450             


Leu Lys  Trp Val Ser Asp Ser  Ala Arg Val Ala Ala  Met Lys Arg 
    3455                 3460                 3465             


Ser Gly  Arg Met Asn Tyr Met  Cys Pro Asn Ser Ser  Thr Val Glu 
    3470                 3475                 3480             


Tyr Gly  Leu Leu Met Pro Ser  Pro Ser His Leu His  Cys Val Ala 
    3485                 3490                 3495             


Ala Ile  Leu Trp His Ser Tyr  Glu Leu Leu Val Glu  Tyr Asp Leu 
    3500                 3505                 3510             


Pro Ala  Leu Leu Asp Gln Glu  Leu Phe Glu Leu Leu  Phe Asn Trp 
    3515                 3520                 3525             


Ser Met  Ser Leu Pro Cys Asn  Met Val Leu Lys Lys  Ala Val Asp 
    3530                 3535                 3540             


Ser Leu  Leu Cys Ser Met Cys  His Val His Pro Asn  Tyr Phe Ser 
    3545                 3550                 3555             


Leu Leu  Met Gly Trp Met Gly  Ile Thr Pro Pro Pro  Val Gln Cys 
    3560                 3565                 3570             


His His  Arg Leu Ser Met Thr  Asp Asp Ser Lys Lys  Gln Asp Leu 
    3575                 3580                 3585             


Ser Ser  Ser Leu Thr Asp Asp  Ser Lys Asn Ala Gln  Ala Pro Leu 
    3590                 3595                 3600             


Ala Leu  Thr Glu Ser His Leu  Ala Thr Leu Ala Ser  Ser Ser Gln 
    3605                 3610                 3615             


Ser Pro  Glu Ala Ile Lys Gln  Leu Leu Asp Ser Gly  Leu Pro Ser 
    3620                 3625                 3630             


Leu Leu  Val Arg Ser Leu Ala  Ser Phe Cys Phe Ser  His Ile Ser 
    3635                 3640                 3645             


Ser Ser  Glu Ser Ile Ala Gln  Ser Ile Asp Ile Ser  Gln Asp Lys 
    3650                 3655                 3660             


Leu Arg  Arg His His Val Pro  Gln Gln Cys Asn Lys  Met Pro Ile 
    3665                 3670                 3675             


Thr Ala  Asp Leu Val Ala Pro  Ile Leu Arg Phe Leu  Thr Glu Val 
    3680                 3685                 3690             


Gly Asn  Ser His Ile Met Lys  Asp Trp Leu Gly Gly  Ser Glu Val 
    3695                 3700                 3705             


Asn Pro  Leu Trp Thr Ala Leu  Leu Phe Leu Leu Cys  His Ser Gly 
    3710                 3715                 3720             


Ser Thr  Ser Gly Ser His Asn  Leu Gly Ala Gln Gln  Thr Ser Ala 
    3725                 3730                 3735             


Arg Ser  Ala Ser Leu Ser Ser  Ala Ala Thr Thr Gly  Leu Thr Thr 
    3740                 3745                 3750             


Gln Gln  Arg Thr Ala Ile Glu  Asn Ala Thr Val Ala  Phe Phe Leu 
    3755                 3760                 3765             


Gln Cys  Ile Ser Cys His Pro  Asn Asn Gln Lys Leu  Met Ala Gln 
    3770                 3775                 3780             


Val Leu  Cys Glu Leu Phe Gln  Thr Ser Pro Gln Arg  Gly Asn Leu 
    3785                 3790                 3795             


Pro Thr  Ser Gly Asn Ile Ser  Gly Phe Ile Arg Arg  Leu Phe Leu 
    3800                 3805                 3810             


Gln Leu  Met Leu Glu Asp Glu  Lys Val Thr Met Phe  Leu Gln Ser 
    3815                 3820                 3825             


Pro Cys  Pro Leu Tyr Lys Gly  Arg Ile Asn Ala Thr  Ser His Val 
    3830                 3835                 3840             


Ile Gln  His Pro Met Tyr Gly  Ala Gly His Lys Phe  Arg Thr Leu 
    3845                 3850                 3855             


His Leu  Pro Val Ser Thr Thr  Leu Ser Asp Val Leu  Asp Arg Val 
    3860                 3865                 3870             


Ser Asp  Thr Pro Ser Ile Thr  Ala Lys Leu Ile Ser  Glu Gln Lys 
    3875                 3880                 3885             


Asp Asp  Lys Glu Lys Lys Asn  His Glu Glu Lys Glu  Lys Val Lys 
    3890                 3895                 3900             


Ala Glu  Asn Gly Phe Gln Asp  Asn Tyr Ser Val Val  Val Ala Ser 
    3905                 3910                 3915             


Gly Leu  Lys Ser Gln Ser Lys  Arg Ala Val Ser Ala  Thr Pro Pro 
    3920                 3925                 3930             


Arg Pro  Pro Ser Arg Arg Gly  Arg Thr Ile Pro Asp  Lys Ile Gly 
    3935                 3940                 3945             


Ser Thr  Ser Gly Ala Glu Ala  Ala Asn Lys Ile Ile  Thr Val Pro 
    3950                 3955                 3960             


Val Phe  His Leu Phe His Lys  Leu Leu Ala Gly Gln  Pro Leu Pro 
    3965                 3970                 3975             


Ala Glu  Met Thr Leu Ala Gln  Leu Leu Thr Leu Leu  Tyr Asp Arg 
    3980                 3985                 3990             


Lys Leu  Pro Gln Gly Tyr Arg  Ser Ile Asp Leu Thr  Val Lys Leu 
    3995                 4000                 4005             


Gly Ser  Arg Val Ile Thr Asp  Pro Ser Leu Ser Lys  Thr Asp Ser 
    4010                 4015                 4020             


Tyr Lys  Arg Leu His Pro Glu  Lys Asp His Gly Asp  Leu Leu Ala 
    4025                 4030                 4035             


Ser Cys  Pro Glu Asp Glu Ala  Leu Thr Pro Gly Asp  Glu Cys Met 
    4040                 4045                 4050             


Asp Gly  Ile Leu Asp Glu Ser  Leu Leu Glu Thr Cys  Pro Ile Gln 
    4055                 4060                 4065             


Ser Pro  Leu Gln Val Phe Ala  Gly Met Gly Gly Leu  Ala Leu Ile 
    4070                 4075                 4080             


Ala Glu  Arg Leu Pro Met Leu  Tyr Pro Glu Val Ile  Gln Gln Val 
    4085                 4090                 4095             


Ser Ala  Pro Val Val Thr Ser  Thr Thr Gln Glu Lys  Pro Lys Asp 
    4100                 4105                 4110             


Ser Asp  Gln Phe Glu Trp Val  Thr Ile Glu Gln Ser  Gly Glu Leu 
    4115                 4120                 4125             


Val Tyr  Glu Ala Pro Glu Thr  Val Ala Ala Glu Pro  Pro Pro Ile 
    4130                 4135                 4140             


Lys Ser  Ala Val Gln Thr Met  Ser Pro Ile Pro Ala  His Ser Leu 
    4145                 4150                 4155             


Ala Ala  Phe Gly Leu Phe Leu  Arg Leu Pro Gly Tyr  Ala Glu Val 
    4160                 4165                 4170             


Leu Leu  Lys Glu Arg Lys His  Ala Gln Cys Leu Leu  Arg Leu Val 
    4175                 4180                 4185             


Leu Gly  Val Thr Asp Asp Gly  Glu Gly Ser His Ile  Leu Gln Ser 
    4190                 4195                 4200             


Pro Ser  Ala Asn Val Leu Pro  Thr Leu Pro Phe His  Val Leu Arg 
    4205                 4210                 4215             


Ser Leu  Phe Ser Thr Thr Pro  Leu Thr Thr Asp Asp  Gly Val Leu 
    4220                 4225                 4230             


Leu Arg  Arg Met Ala Leu Glu  Ile Gly Ala Leu His  Leu Ile Leu 
    4235                 4240                 4245             


Val Cys  Leu Ser Ala Leu Ser  His His Ser Pro Arg  Val Pro Asn 
    4250                 4255                 4260             


Ser Ser  Val Asn Gln Thr Glu  Pro Gln Val Ser Ser  Ser His Asn 
    4265                 4270                 4275             


Pro Thr  Ser Thr Glu Glu Gln  Gln Leu Tyr Trp Ala  Lys Gly Thr 
    4280                 4285                 4290             


Gly Phe  Gly Thr Gly Ser Thr  Ala Ser Gly Trp Asp  Val Glu Gln 
    4295                 4300                 4305             


Ala Leu  Thr Lys Gln Arg Leu  Glu Glu Glu His Val  Thr Cys Leu 
    4310                 4315                 4320             


Leu Gln  Val Leu Ala Ser Tyr  Ile Asn Pro Val Ser  Ser Ala Val 
    4325                 4330                 4335             


Asn Gly  Glu Ala Gln Ser Ser  His Glu Thr Arg Gly  Gln Asn Ser 
    4340                 4345                 4350             


Asn Ala  Leu Pro Ser Val Leu  Leu Glu Leu Leu Ser  Gln Ser Cys 
    4355                 4360                 4365             


Leu Ile  Pro Ala Met Ser Ser  Tyr Leu Arg Asn Asp  Ser Val Leu 
    4370                 4375                 4380             


Asp Met  Ala Arg His Val Pro  Leu Tyr Arg Ala Leu  Leu Glu Leu 
    4385                 4390                 4395             


Leu Arg  Ala Ile Ala Ser Cys  Ala Ala Met Val Pro  Leu Leu Leu 
    4400                 4405                 4410             


Pro Leu  Ser Thr Glu Asn Gly  Glu Glu Glu Glu Glu  Gln Ser Glu 
    4415                 4420                 4425             


Cys Gln  Thr Ser Val Gly Thr  Leu Leu Ala Lys Met  Lys Thr Cys 
    4430                 4435                 4440             


Val Asp  Thr Tyr Thr Asn Arg  Leu Arg Ser Lys Arg  Glu Asn Val 
    4445                 4450                 4455             


Lys Thr  Gly Val Lys Pro Asp  Ala Ser Asp Gln Glu  Pro Glu Gly 
    4460                 4465                 4470             


Leu Thr  Leu Leu Val Pro Asp  Ile Gln Lys Thr Ala  Glu Ile Val 
    4475                 4480                 4485             


Tyr Ala  Ala Thr Thr Ser Leu  Arg Gln Ala Asn Gln  Glu Lys Lys 
    4490                 4495                 4500             


Leu Gly  Glu Tyr Ser Lys Lys  Ala Ala Met Lys Pro  Lys Pro Leu 
    4505                 4510                 4515             


Ser Val  Leu Lys Ser Leu Glu  Glu Lys Tyr Val Ala  Val Met Lys 
    4520                 4525                 4530             


Lys Leu  Gln Phe Asp Thr Phe  Glu Met Val Ser Glu  Asp Glu Asp 
    4535                 4540                 4545             


Gly Lys  Leu Gly Phe Lys Val  Asn Tyr His Tyr Met  Ser Gln Val 
    4550                 4555                 4560             


Lys Asn  Ala Asn Asp Ala Asn  Ser Ala Ala Arg Ala  Arg Arg Leu 
    4565                 4570                 4575             


Ala Gln  Glu Ala Val Thr Leu  Ser Thr Ser Leu Pro  Leu Ser Ser 
    4580                 4585                 4590             


Ser Ser  Ser Val Phe Val Arg  Cys Asp Glu Glu Arg  Leu Asp Ile 
    4595                 4600                 4605             


Met Lys  Val Leu Ile Thr Gly  Pro Ala Asp Thr Pro  Tyr Ala Asn 
    4610                 4615                 4620             


Gly Cys  Phe Glu Phe Asp Val  Tyr Phe Pro Gln Asp  Tyr Pro Ser 
    4625                 4630                 4635             


Ser Pro  Pro Leu Val Asn Leu  Glu Thr Thr Gly Gly  His Ser Val 
    4640                 4645                 4650             


Arg Phe  Asn Pro Asn Leu Tyr  Asn Asp Gly Lys Val  Cys Leu Ser 
    4655                 4660                 4665             


Ile Leu  Asn Thr Trp His Gly  Arg Pro Glu Glu Lys  Trp Asn Pro 
    4670                 4675                 4680             


Gln Thr  Ser Ser Phe Leu Gln  Val Leu Val Ser Val  Gln Ser Leu 
    4685                 4690                 4695             


Ile Leu  Val Ala Glu Pro Tyr  Phe Asn Glu Pro Gly  Tyr Glu Arg 
    4700                 4705                 4710             


Ser Arg  Gly Thr Pro Ser Gly  Thr Gln Ser Ser Arg  Glu Tyr Asp 
    4715                 4720                 4725             


Gly Asn  Ile Arg Gln Ala Thr  Val Lys Trp Ala Met  Leu Glu Gln 
    4730                 4735                 4740             


Ile Arg  Asn Pro Ser Pro Cys  Phe Lys Glu Val Ile  His Lys His 
    4745                 4750                 4755             


Phe Tyr  Leu Lys Arg Val Glu  Ile Met Ala Gln Cys  Glu Glu Trp 
    4760                 4765                 4770             


Ile Ala  Asp Ile Gln Gln Tyr  Ser Ser Asp Lys Arg  Val Gly Arg 
    4775                 4780                 4785             


Thr Met  Ser His His Ala Ala  Ala Leu Lys Arg His  Thr Ala Gln 
    4790                 4795                 4800             


Leu Arg  Glu Glu Leu Leu Lys  Leu Pro Cys Pro Glu  Gly Leu Asp 
    4805                 4810                 4815             


Pro Asp  Thr Asp Asp Ala Pro  Glu Val Cys Arg Ala  Thr Thr Gly 
    4820                 4825                 4830             


Ala Glu  Glu Thr Leu Met His  Asp Gln Val Lys Pro  Ser Ser Ser 
    4835                 4840                 4845             


Lys Glu  Leu Pro Ser Asp Phe  Gln Leu 
    4850                 4855         


<210>  197
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Ser Ser Ser Gly Leu Asn Ser Glu Lys Val Ala Ala Leu Ile Gln 
1               5                   10                  15      


Lys Leu Asn Ser Asp Pro Gln Phe Val Leu Ala Gln Asn Val Gly Thr 
            20                  25                  30          


Thr His Asp Leu Leu Asp Ile Cys Leu Lys Arg Ala Thr Val Gln Arg 
        35                  40                  45              


Ala Gln His Val Phe Gln His Ala Val Pro Gln Glu Gly Lys Pro Ile 
    50                  55                  60                  


Thr Asn Gln Lys Ser Ser Gly Arg Cys Trp Ile Phe Ser Cys Leu Asn 
65                  70                  75                  80  


Val Met Arg Leu Pro Phe Met Lys Lys Leu Asn Ile Glu Glu Phe Glu 
                85                  90                  95      


Phe Ser Gln Ser Tyr Leu Phe Phe Trp Asp Lys Val Glu Arg Cys Tyr 
            100                 105                 110         


Phe Phe Leu Ser Ala Phe Val Asp Thr Ala Gln Arg Lys Glu Pro Glu 
        115                 120                 125             


Asp Gly Arg Leu Val Gln Phe Leu Leu Met Asn Pro Ala Asn Asp Gly 
    130                 135                 140                 


Gly Gln Trp Asp Met Leu Val Asn Ile Val Glu Lys Tyr Gly Val Ile 
145                 150                 155                 160 


Pro Lys Lys Cys Phe Pro Glu Ser Tyr Thr Thr Glu Ala Thr Arg Arg 
                165                 170                 175     


Met Asn Asp Ile Leu Asn His Lys Met Arg Glu Phe Cys Ile Arg Leu 
            180                 185                 190         


Arg Asn Leu Val His Ser Gly Ala Thr Lys Gly Glu Ile Ser Ala Thr 
        195                 200                 205             


Gln Asp Val Met Met Glu Glu Ile Phe Arg Val Val Cys Ile Cys Leu 
    210                 215                 220                 


Gly Asn Pro Pro Glu Thr Phe Thr Trp Glu Tyr Arg Asp Lys Asp Lys 
225                 230                 235                 240 


Asn Tyr Gln Lys Ile Gly Pro Ile Thr Pro Leu Glu Phe Tyr Arg Glu 
                245                 250                 255     


His Val Lys Pro Leu Phe Asn Met Glu Asp Lys Ile Cys Leu Val Asn 
            260                 265                 270         


Asp Pro Arg Pro Gln His Lys Tyr Asn Lys Leu Tyr Thr Val Glu Tyr 
        275                 280                 285             


Leu Ser Asn Met Val Gly Gly Arg Lys Thr Leu Tyr Asn Asn Gln Pro 
    290                 295                 300                 


Ile Asp Phe Leu Lys Lys Met Val Ala Ala Ser Ile Lys Asp Gly Glu 
305                 310                 315                 320 


Ala Val Trp Phe Gly Cys Asp Val Gly Lys His Phe Asn Ser Lys Leu 
                325                 330                 335     


Gly Leu Ser Asp Met Asn Leu Tyr Asp His Glu Leu Val Phe Gly Val 
            340                 345                 350         


Ser Leu Lys Asn Met Asn Lys Ala Glu Arg Leu Thr Phe Gly Glu Ser 
        355                 360                 365             


Leu Met Thr His Ala Met Thr Phe Thr Ala Val Ser Glu Lys Asp Asp 
    370                 375                 380                 


Gln Asp Gly Ala Phe Thr Lys Trp Arg Val Glu Asn Ser Trp Gly Glu 
385                 390                 395                 400 


Asp His Gly His Lys Gly Tyr Leu Cys Met Thr Asp Glu Trp Phe Ser 
                405                 410                 415     


Glu Tyr Val Tyr Glu Val Val Val Asp Arg Lys His Val Pro Glu Glu 
            420                 425                 430         


Val Leu Ala Val Leu Glu Gln Glu Pro Ile Ile Leu Pro Ala Trp Asp 
        435                 440                 445             


Pro Met Gly Ala Leu Ala Glu 
    450                 455 


<210>  198
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Arg Ile Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Thr Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Asn Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Thr Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Val Pro Gln Ser Val Thr Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Leu Val Met Leu Glu Thr Leu Ser Gln Ser Pro Gln Gly 
                165                 170                 175     


Arg Val Met Thr Ile Pro Tyr Gln Pro Met Pro Ala Ser Ser Pro Val 
            180                 185                 190         


Ile Cys Ala Gly Gly Gln Asp Arg Cys Ser Asp Ala Ala Gly Tyr Pro 
        195                 200                 205             


His Ala Thr His Asp Leu Glu Gly Pro Pro Leu Asp Ala Tyr Ser Ile 
    210                 215                 220                 


Gln Gly Gln His Thr Ile Ser Pro Leu Asp Leu Ala Lys Leu Asn Gln 
225                 230                 235                 240 


Val Ala Arg Gln Gln Ser His Phe Ala Met Met His Gly Gly Thr Gly 
                245                 250                 255     


Phe Ala Gly Ile Asp Ser Ser Ser Pro Glu Val Lys Gly Tyr Trp Ala 
            260                 265                 270         


Ser Leu Asp Ala Ser Thr Gln Thr Thr His Glu Leu Thr Ile Pro Asn 
        275                 280                 285             


Asn Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala Asn Ile Asn Glu 
    290                 295                 300                 


Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Pro Val Glu 
305                 310                 315                 320 


Gly Ser Ser Gly Arg Gln Val Thr Ile Thr Gly Ser Ala Ala Ser Ile 
                325                 330                 335     


Ser Leu Ala Gln Tyr Leu Ile Asn Ala Arg Leu Ser Ser Glu Lys Gly 
            340                 345                 350         


Met Gly Cys Ser 
        355     


<210>  199
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  200
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  201
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210>  202
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu 
1               5                   10                  15      


Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala 
            20                  25                  30          


Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala 
        35                  40                  45              


Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val 
    50                  55                  60                  


Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro 
65                  70                  75                  80  


Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser 
                85                  90                  95      


Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu 
            100                 105                 110         


Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly 
        115                 120                 125             


Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg 
    130                 135                 140                 


Thr Val Gly Val Ser Lys Lys Lys 
145                 150         


<210>  203
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn 
1               5                   10                  15      


Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
            20                  25                  30          


Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile 
        35                  40                  45              


Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr 
    50                  55                  60                  


Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly 
                85                  90                  95      


Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser 
            100                 105                 110         


Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu 
        115                 120                 125             


Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys 
    130                 135                 140                 


Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile 
145                 150                 155                 160 


Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val 
                165                 170                 175     


Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg 
            180                 185                 190         


Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu 
        195                 200                 205             


Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe 
    210                 215                 220                 


His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile 
225                 230                 235                 240 


Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu 
                245                 250                 255     


Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly 
            260                 265                 270         


Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr 
        275                 280                 285             


Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu 
    290                 295                 300                 


Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu 
305                 310                 315                 320 


Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro 
                325                 330                 335     


Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val 
            340                 345                 350         


Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro 
        355                 360                 365             


Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp 
    370                 375                 380                 


Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser 
385                 390                 395         


<210>  204
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Gly Lys Val Trp Lys Gln Gln Met Tyr Pro Gln Tyr Ala Thr Tyr 
1               5                   10                  15      


Tyr Tyr Pro Gln Tyr Leu Gln Ala Lys Gln Ser Leu Val Pro Ala His 
            20                  25                  30          


Pro Met Ala Pro Pro Ser Pro Ser Thr Thr Ser Ser Asn Asn Asn Ser 
        35                  40                  45              


Ser Ser Ser Ser Asn Ser Gly Trp Asp Gln Leu Ser Lys Thr Asn Leu 
    50                  55                  60                  


Tyr Ile Arg Gly Leu Pro Pro His Thr Thr Asp Gln Asp Leu Val Lys 
65                  70                  75                  80  


Leu Cys Gln Pro Tyr Gly Lys Ile Val Ser Thr Lys Ala Ile Leu Asp 
                85                  90                  95      


Lys Thr Thr Asn Lys Cys Lys Gly Tyr Gly Phe Val Asp Phe Asp Ser 
            100                 105                 110         


Pro Ala Ala Ala Gln Lys Ala Val Ser Ala Leu Lys Ala Ser Gly Val 
        115                 120                 125             


Gln Ala Gln Met Ala Lys Gln Gln Glu Gln Asp Pro Thr Asn Leu Tyr 
    130                 135                 140                 


Ile Ser Asn Leu Pro Leu Ser Met Asp Glu Gln Glu Leu Glu Asn Met 
145                 150                 155                 160 


Leu Lys Pro Phe Gly Gln Val Ile Ser Thr Arg Ile Leu Arg Asp Ser 
                165                 170                 175     


Ser Gly Thr Ser Arg Gly Val Gly Phe Ala Arg Met Glu Ser Thr Glu 
            180                 185                 190         


Lys Cys Glu Ala Val Ile Gly His Phe Asn Gly Lys Phe Ile Lys Thr 
        195                 200                 205             


Pro Pro Gly Val Ser Ala Pro Thr Glu Pro Leu Leu Cys Lys Phe Ala 
    210                 215                 220                 


Asp Gly Gly Gln Lys Lys Arg Gln Asn Pro Asn Lys Tyr Ile Pro Asn 
225                 230                 235                 240 


Gly Arg Pro Trp His Arg Glu Gly Glu Val Arg Leu Ala Gly Met Thr 
                245                 250                 255     


Leu Thr Tyr Asp Pro Thr Thr Ala Ala Ile Gln Asn Gly Phe Tyr Pro 
            260                 265                 270         


Ser Pro Tyr Ser Ile Ala Thr Asn Arg Met Ile Thr Gln Thr Ser Ile 
        275                 280                 285             


Thr Pro Tyr Ile Ala Ser Pro Val Ser Ala Tyr Gln Val Gln Ser Pro 
    290                 295                 300                 


Ser Trp Met Gln Pro Gln Pro Tyr Ile Leu Gln His Pro Gly Ala Val 
305                 310                 315                 320 


Leu Thr Pro Ser Met Glu His Thr Met Ser Leu Gln Pro Ala Ser Met 
                325                 330                 335     


Ile Ser Pro Leu Ala Gln Gln Met Ser His Leu Ser Leu Gly Ser Thr 
            340                 345                 350         


Gly Thr Tyr Met Pro Ala Thr Ser Ala Met Gln Gly Ala Tyr Leu Pro 
        355                 360                 365             


Gln Tyr Ala His Met Gln Thr Thr Ala Val Pro Val Glu Glu Ala Ser 
    370                 375                 380                 


Gly Gln Gln Gln Val Ala Val Glu Thr Ser Asn Asp His Ser Pro Tyr 
385                 390                 395                 400 


Thr Phe Gln Pro Asn Lys 
                405     


<210>  205
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Pro Gly Val Thr Val Lys Asp Val Asn Gln Gln Glu Phe Val Arg 
1               5                   10                  15      


Ala Leu Ala Ala Phe Leu Lys Lys Ser Gly Lys Leu Lys Val Pro Glu 
            20                  25                  30          


Trp Val Asp Thr Val Lys Leu Ala Lys His Lys Glu Leu Ala Pro Tyr 
        35                  40                  45              


Asp Glu Asn Trp Phe Tyr Thr Arg Ala Ala Ser Thr Ala Arg His Leu 
    50                  55                  60                  


Tyr Leu Arg Gly Gly Ala Gly Val Gly Ser Met Thr Lys Ile Tyr Gly 
65                  70                  75                  80  


Gly Arg Gln Arg Asn Gly Val Met Pro Ser His Phe Ser Arg Gly Ser 
                85                  90                  95      


Lys Ser Val Ala Arg Arg Val Leu Gln Ala Leu Glu Gly Leu Lys Met 
            100                 105                 110         


Val Glu Lys Asp Gln Asp Gly Gly Arg Lys Leu Thr Pro Gln Gly Gln 
        115                 120                 125             


Arg Asp Leu Asp Arg Ile Ala Gly Gln Val Ala Ala Ala Asn Lys Lys 
    130                 135                 140                 


His 
145 


<210>  206
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Arg Glu Cys Ile Ser Val His Val Gly Gln Ala Gly Val Gln Met 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Thr Thr Phe Phe Cys Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Ile Arg Asn 
65                  70                  75                  80  


Gly Pro Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Pro Val Leu Asp Arg Ile Arg Lys Leu Ser Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Ala Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Ile Asp Ser Tyr Glu Asp Glu Asp Glu Gly Glu Glu 
        435                 440                 445             


<210>  207
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Glu Glu Thr Gln Pro Pro Pro Gln Pro Lys Leu Pro Leu Cys Asp 
1               5                   10                  15      


Ser Leu Met Ile Trp Leu Gln Thr Phe Asn Thr Ala Ser Pro Cys Gln 
            20                  25                  30          


Asp Val Lys Gln Leu Thr Ser Gly Val Ala Met Ala Gln Val Leu His 
        35                  40                  45              


Gln Ile Asp Ala Ala Trp Phe Asn Glu Ser Trp Leu Ser Arg Ile Lys 
    50                  55                  60                  


Glu Asp Val Gly Asp Asn Trp Arg Ile Lys Ala Ser Asn Val Lys Lys 
65                  70                  75                  80  


Val Leu Gln Gly Ile Met Ser Tyr Tyr His Glu Phe Leu Gly Gln Gln 
                85                  90                  95      


Ile Ser Glu Ala Leu Ile Pro Asp Leu Asn Gln Ile Thr Glu Cys Ser 
            100                 105                 110         


Asp Pro Val Glu Leu Gly Arg Leu Leu Gln Leu Ile Leu Gly Cys Ala 
        115                 120                 125             


Ile Asn Cys Glu Lys Lys Gln Glu His Ile Gln Asn Ile Met Thr Leu 
    130                 135                 140                 


Glu Glu Ser Val Gln His Val Val Met Thr Ala Ile Gln Glu Leu Met 
145                 150                 155                 160 


Ser Lys Glu Ile Leu Ser Ser Pro Pro Asn Asp Ala Val Gly Glu Leu 
                165                 170                 175     


Glu Gln Gln Leu Lys Arg Ala Leu Glu Glu Leu Gln Glu Ala Leu Ala 
            180                 185                 190         


Glu Lys Glu Glu Leu Arg Gln Arg Cys Glu Glu Leu Asp Met Gln Val 
        195                 200                 205             


Thr Thr Leu Gln Asp Glu Lys Asn Ser Leu Val Ser Glu Asn Glu Met 
    210                 215                 220                 


Met Asn Glu Lys Leu Asp Gln Leu Asp Gly Ser Phe Asp Asp Pro Asn 
225                 230                 235                 240 


Thr Val Val Ala Lys Lys Tyr Phe His Ala Gln Leu Gln Leu Glu Gln 
                245                 250                 255     


Leu Gln Glu Glu Asn Phe Arg Leu Glu Ala Ala Lys Asp Asp Tyr Arg 
            260                 265                 270         


Val His Cys Glu Glu Leu Glu Lys Gln Leu Ile Glu Phe Gln His Arg 
        275                 280                 285             


Asn Asp Glu Leu Thr Ser Leu Ala Glu Glu Thr Arg Ala Leu Lys Asp 
    290                 295                 300                 


Glu Ile Asp Val Leu Arg Ala Thr Ser Asp Lys Ala Asn Lys Leu Glu 
305                 310                 315                 320 


Ser Thr Val Glu Ile Tyr Arg Gln Lys Leu Gln Asp Leu Asn Asp Leu 
                325                 330                 335     


Arg Lys Gln Val Lys Thr Leu Gln Glu Thr Asn Met Met Tyr Met His 
            340                 345                 350         


Asn Thr Val Ser Leu Glu Glu Glu Leu Lys Lys Ala Asn Ala Ala Arg 
        355                 360                 365             


Thr Gln Leu Glu Thr Tyr Lys Arg Gln Val Gln Asp Leu His Val Lys 
    370                 375                 380                 


Leu Ser Ser Glu Ser Lys Arg Ala Asp Thr Leu Ala Phe Glu Met Lys 
385                 390                 395                 400 


Arg Leu Glu Glu Lys His Glu Ala Leu Leu Lys Glu Lys Glu Arg Leu 
                405                 410                 415     


Ile Glu Gln Arg Asp Thr Leu Lys Glu Thr Asn Glu Glu Leu Arg Cys 
            420                 425                 430         


Ser Gln Val Gln Gln Asp His Leu Asn Gln Thr Asp Ala Ser Ala Thr 
        435                 440                 445             


Lys Ser Tyr Glu Asn Leu Ala Ala Glu Ile Met Pro Val Glu Tyr Arg 
    450                 455                 460                 


Glu Val Phe Ile Arg Leu Gln His Glu Asn Lys Met Leu Arg Leu Gln 
465                 470                 475                 480 


Gln Glu Gly Ser Glu Asn Glu Arg Ile Glu Glu Leu Gln Glu Gln Leu 
                485                 490                 495     


Glu Gln Lys His Arg Lys Met Asn Glu Leu Glu Thr Glu Gln Arg Leu 
            500                 505                 510         


Ser Lys Glu Arg Ile Arg Glu Leu Gln Gln Gln Ile Glu Asp Leu Gln 
        515                 520                 525             


Lys Ser Leu Gln Glu Gln Gly Ser Lys Ser Glu Gly Glu Ser Ser Ser 
    530                 535                 540                 


Lys Leu Lys Gln Lys Leu Glu Ala His Met Glu Lys Leu Thr Glu Val 
545                 550                 555                 560 


His Glu Glu Leu Gln Lys Lys Gln Glu Leu Ile Glu Asp Leu Gln Pro 
                565                 570                 575     


Asp Ile Asn Gln Asn Val Gln Lys Ile Asn Glu Leu Glu Ala Ala Leu 
            580                 585                 590         


Gln Lys Lys Asp Glu Asp Met Lys Ala Met Glu Glu Arg Tyr Lys Met 
        595                 600                 605             


Tyr Leu Glu Lys Ala Arg Asn Val Ile Lys Thr Leu Asp Pro Lys Leu 
    610                 615                 620                 


Asn Pro Ala Ser Ala Glu Ile Met Leu Leu Arg Lys Gln Leu Ala Glu 
625                 630                 635                 640 


Lys Glu Arg Arg Ile Glu Ile Leu Glu Ser Glu Cys Lys Val Ala Lys 
                645                 650                 655     


Phe Arg Asp Tyr Glu Glu Lys Leu Ile Val Ser Ala Trp Tyr Asn Lys 
            660                 665                 670         


Ser Leu Ala Phe Gln Lys Leu Gly Met Glu Ser Arg Leu Val Ser Gly 
        675                 680                 685             


Gly Gly Ala Cys Ser Asp Thr Gly Ala Cys Thr Pro Ala Arg Ser Phe 
    690                 695                 700                 


Leu Ala Gln Gln Arg His Ile Thr Asn Thr Arg Arg Asn Leu Ser Val 
705                 710                 715                 720 


Lys Val Pro Ala Thr Thr Ser Asp 
                725             


<210>  208
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile Pro 
        515                 520                 525             


Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser Leu 
    530                 535                 540                 


Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Thr 
545                 550                 555                 560 


Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile Met 
                565                 570                 575     


Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro 
            580                 585                 590         


Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala 
        595                 600                 605             


Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr Val 
    610                 615                 620                 


Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg 
625                 630                 635                 640 


Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Thr 
                645                 650                 655     


Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu Glu 
            660                 665                 670         


Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly 
        675                 680                 685             


Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr 
    690                 695                 700                 


Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr Phe 
705                 710                 715                 720 


Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr Ile 
                725                 730                 735     


Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr Tyr 
            740                 745                 750         


Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val 
        755                 760                 765             


Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Thr 
    770                 775                 780                 


Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu 
785                 790                 795                 800 


Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser Gly 
                805                 810                 815     


Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro Pro 
            820                 825                 830         


Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val Ala 
        835                 840                 845             


Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser 
    850                 855                 860                 


Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg Ala 
865                 870                 875                 880 


Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser Ala 
                885                 890                 895     


Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu Pro 
            900                 905                 910         


Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg 
        915                 920                 925             


Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala 
    930                 935                 940                 


Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu 
945                 950                 955                 960 


Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu Gly 
                965                 970                 975     


Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys Ser 
            980                 985                 990         


Ser Pro Asp Glu Gly Ser Phe Leu  Tyr Thr Leu Pro Asp  Asp Ser Thr 
        995                 1000                 1005             


His Gln  Leu Leu Gln Pro His  His Asp Cys Cys Gln  Arg Gln Glu 
    1010                 1015                 1020             


Gln Pro  Ala Ala Val Gly Gln  Ser Gly Val Arg Arg  Ala Pro Asp 
    1025                 1030                 1035             


Ser Pro  Val Leu Glu Ala Val  Trp Asp Pro Pro Phe  His Ser Gly 
    1040                 1045                 1050             


Pro Pro  Cys Cys Leu Gly Leu  Val Pro Val Glu Glu  Val Asp Ser 
    1055                 1060                 1065             


Pro Asp  Ser Cys Gln Val Ser  Gly Gly Asp Trp Cys  Pro Gln His 
    1070                 1075                 1080             


Pro Val  Gly Ala Tyr Val Gly  Gln Glu Pro Gly Met  Gln Leu Ser 
    1085                 1090                 1095             


Pro Gly  Pro Leu Val Arg Val  Ser Phe Glu Thr Pro  Pro Leu Thr 
    1100                 1105                 1110             


Ile 
    


<210>  209
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Val Leu Ala Asp Leu Gly Arg Lys Ile Thr Ser Ala Leu Arg Ser 
1               5                   10                  15      


Leu Ser Asn Ala Thr Ile Ile Asn Glu Glu Val Leu Asn Ala Met Leu 
            20                  25                  30          


Lys Glu Val Cys Thr Ala Leu Leu Glu Ala Asp Val Asn Ile Lys Leu 
        35                  40                  45              


Val Lys Gln Leu Arg Glu Asn Val Lys Ser Ala Ile Asp Leu Glu Glu 
    50                  55                  60                  


Met Ala Ser Gly Leu Asn Lys Arg Lys Met Ile Gln His Ala Val Phe 
65                  70                  75                  80  


Lys Glu Leu Val Lys Leu Val Asp Pro Gly Val Lys Ala Trp Thr Pro 
                85                  90                  95      


Thr Lys Gly Lys Gln Asn Val Ile Met Phe Val Gly Leu Gln Gly Ser 
            100                 105                 110         


Gly Lys Thr Thr Thr Cys Ser Lys Leu Ala Tyr Tyr Tyr Gln Arg Lys 
        115                 120                 125             


Gly Trp Lys Thr Cys Leu Ile Cys Ala Asp Thr Phe Arg Ala Gly Ala 
    130                 135                 140                 


Phe Asp Gln Leu Lys Gln Asn Ala Thr Lys Ala Arg Ile Pro Phe Tyr 
145                 150                 155                 160 


Gly Ser Tyr Thr Glu Met Asp Pro Val Ile Ile Ala Ser Glu Gly Val 
                165                 170                 175     


Glu Lys Phe Lys Asn Glu Asn Phe Glu Ile Ile Ile Val Asp Thr Ser 
            180                 185                 190         


Gly Arg His Lys Gln Glu Asp Ser Leu Phe Glu Glu Met Leu Gln Val 
        195                 200                 205             


Ala Asn Ala Ile Gln Pro Asp Asn Ile Val Tyr Val Met Asp Ala Ser 
    210                 215                 220                 


Ile Gly Gln Ala Cys Glu Ala Gln Ala Lys Ala Phe Lys Asp Lys Val 
225                 230                 235                 240 


Asp Val Ala Ser Val Ile Val Thr Lys Leu Asp Gly His Ala Lys Gly 
                245                 250                 255     


Gly Gly Ala Leu Ser Ala Val Ala Ala Thr Lys Ser Pro Ile Ile Phe 
            260                 265                 270         


Ile Gly Thr Gly Glu His Ile Asp Asp Phe Glu Pro Phe Lys Thr Gln 
        275                 280                 285             


Pro Phe Ile Ser Lys Leu Leu Gly Met Gly Asp Ile Glu Gly Leu Ile 
    290                 295                 300                 


Asp Lys Val Asn Glu Leu Lys Leu Asp Asp Asn Glu Ala Leu Ile Glu 
305                 310                 315                 320 


Lys Leu Lys His Gly Gln Phe Thr Leu Arg Asp Met Tyr Glu Gln Phe 
                325                 330                 335     


Gln Asn Ile Met Lys Met Gly Pro Phe Ser Gln Ile Leu Gly Met Ile 
            340                 345                 350         


Pro Gly Phe Gly Thr Asp Phe Met Ser Lys Gly Asn Glu Gln Glu Ser 
        355                 360                 365             


Met Ala Arg Leu Lys Lys Leu Met Thr Ile Met Asp Ser Met Asn Asp 
    370                 375                 380                 


Gln Glu Leu Asp Ser Thr Asp Gly Ala Lys Val Phe Ser Lys Gln Pro 
385                 390                 395                 400 


Gly Arg Ile Gln Arg Val Ala Arg Gly Ser Gly Val Ser Thr Arg Asp 
                405                 410                 415     


Val Gln Glu Leu Leu Thr Gln Tyr Thr Lys Phe Ala Gln Met Val Lys 
            420                 425                 430         


Lys Met Gly Gly Ile Lys Gly Leu Phe Lys Gly Gly Asp Met Ser Lys 
        435                 440                 445             


Asn Val Ser Gln Ser Gln Met Ala Lys Leu Asn Gln Gln Met Ala Lys 
    450                 455                 460                 


Met Met Asp Pro Arg Val Leu His His Met Gly Gly Met Ala Gly Leu 
465                 470                 475                 480 


Gln Ser Met Met Arg Gln Phe Gln Gln Gly Ala Ala Gly Asn Met Lys 
                485                 490                 495     


Gly Met Met Gly Phe Asn Asn Met 
            500                 


<210>  210
<211>  1833
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Arg Glu Lys Glu Gln Glu Arg Glu Glu Gln Leu Met Glu Asp Lys 
1               5                   10                  15      


Lys Arg Lys Lys Glu Asp Lys Lys Lys Lys Glu Ala Thr Gln Lys Val 
            20                  25                  30          


Thr Glu Gln Lys Thr Lys Val Pro Glu Val Thr Lys Pro Ser Leu Ser 
        35                  40                  45              


Gln Pro Thr Ala Ala Ser Pro Ile Gly Ser Ser Pro Ser Pro Pro Val 
    50                  55                  60                  


Asn Gly Gly Asn Asn Ala Lys Arg Val Ala Val Pro Asn Gly Gln Pro 
65                  70                  75                  80  


Pro Ser Ala Ala Arg Tyr Met Pro Arg Glu Val Pro Pro Arg Phe Arg 
                85                  90                  95      


Cys Gln Gln Asp His Lys Val Leu Leu Lys Arg Gly Gln Pro Pro Pro 
            100                 105                 110         


Pro Ser Cys Met Leu Leu Gly Gly Gly Ala Gly Pro Pro Pro Cys Thr 
        115                 120                 125             


Ala Pro Gly Ala Asn Pro Asn Asn Ala Gln Val Thr Gly Ala Leu Leu 
    130                 135                 140                 


Gln Ser Glu Ser Gly Thr Ala Pro Asp Ser Thr Leu Gly Gly Ala Ala 
145                 150                 155                 160 


Ala Ser Asn Tyr Ala Asn Ser Thr Trp Gly Ser Gly Ala Ser Ser Asn 
                165                 170                 175     


Asn Gly Thr Ser Pro Asn Pro Ile His Ile Trp Asp Lys Val Ile Val 
            180                 185                 190         


Asp Gly Ser Asp Met Glu Glu Trp Pro Cys Ile Ala Ser Lys Asp Thr 
        195                 200                 205             


Glu Ser Ser Ser Glu Asn Thr Thr Asp Asn Asn Ser Ala Ser Asn Pro 
    210                 215                 220                 


Gly Ser Glu Lys Ser Thr Leu Pro Gly Ser Thr Thr Ser Asn Lys Gly 
225                 230                 235                 240 


Lys Gly Ser Gln Cys Gln Ser Ala Ser Ser Gly Asn Glu Cys Asn Leu 
                245                 250                 255     


Gly Val Trp Lys Ser Asp Pro Lys Ala Lys Ser Val Gln Ser Ser Asn 
            260                 265                 270         


Ser Thr Thr Glu Asn Asn Asn Gly Leu Gly Asn Trp Arg Asn Val Ser 
        275                 280                 285             


Gly Gln Asp Arg Ile Gly Pro Gly Ser Gly Phe Ser Asn Phe Asn Pro 
    290                 295                 300                 


Asn Ser Asn Pro Ser Ala Trp Pro Ala Leu Val Gln Glu Gly Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ala Leu Glu Thr Asp Asn Ser Asn Ser Ser Ala Gln Val 
                325                 330                 335     


Ser Thr Val Gly Gln Thr Ser Arg Glu Gln Gln Ser Lys Met Glu Asn 
            340                 345                 350         


Ala Gly Val Asn Phe Val Val Ser Gly Arg Glu Gln Ala Gln Ile His 
        355                 360                 365             


Asn Thr Asp Gly Pro Lys Asn Gly Asn Thr Asn Ser Leu Asn Leu Ser 
    370                 375                 380                 


Ser Pro Asn Pro Met Glu Asn Lys Gly Met Pro Phe Gly Met Gly Leu 
385                 390                 395                 400 


Gly Asn Thr Ser Arg Ser Thr Asp Ala Pro Ser Gln Ser Thr Gly Asp 
                405                 410                 415     


Arg Lys Thr Gly Ser Val Gly Ser Trp Gly Ala Ala Arg Gly Pro Ser 
            420                 425                 430         


Gly Thr Asp Thr Val Ser Gly Gln Ser Asn Ser Gly Asn Asn Gly Asn 
        435                 440                 445             


Asn Gly Lys Glu Arg Glu Asp Ser Trp Lys Gly Ala Ser Val Gln Lys 
    450                 455                 460                 


Ser Thr Gly Ser Lys Asn Asp Ser Trp Asp Asn Asn Asn Arg Ser Thr 
465                 470                 475                 480 


Gly Gly Ser Trp Asn Phe Gly Pro Gln Asp Ser Asn Asp Asn Lys Trp 
                485                 490                 495     


Gly Glu Gly Asn Lys Met Thr Ser Gly Val Ser Gln Gly Glu Trp Lys 
            500                 505                 510         


Gln Pro Thr Gly Ser Asp Glu Leu Lys Ile Gly Glu Trp Ser Gly Pro 
        515                 520                 525             


Asn Gln Pro Asn Ser Ser Thr Gly Ala Trp Asp Asn Gln Lys Gly His 
    530                 535                 540                 


Pro Leu Pro Glu Asn Gln Gly Asn Ala Gln Ala Pro Cys Trp Gly Arg 
545                 550                 555                 560 


Ser Ser Ser Ser Thr Gly Ser Glu Val Gly Gly Gln Ser Thr Gly Ser 
                565                 570                 575     


Asn His Lys Ala Gly Ser Ser Asp Ser His Asn Ser Gly Arg Arg Ser 
            580                 585                 590         


Tyr Arg Pro Thr His Pro Asp Cys Gln Ala Val Leu Gln Thr Leu Leu 
        595                 600                 605             


Ser Arg Thr Asp Leu Asp Pro Arg Val Leu Ser Asn Thr Gly Trp Gly 
    610                 615                 620                 


Gln Thr Gln Ile Lys Gln Asp Thr Val Trp Asp Ile Glu Glu Val Pro 
625                 630                 635                 640 


Arg Pro Glu Gly Lys Ser Asp Lys Gly Thr Glu Gly Trp Glu Ser Ala 
                645                 650                 655     


Ala Thr Gln Thr Lys Asn Ser Gly Gly Trp Gly Asp Ala Pro Ser Gln 
            660                 665                 670         


Ser Asn Gln Met Lys Ser Gly Trp Gly Glu Leu Ser Ala Ser Thr Glu 
        675                 680                 685             


Trp Lys Asp Pro Lys Asn Thr Gly Gly Trp Asn Asp Tyr Lys Asn Asn 
    690                 695                 700                 


Asn Ser Ser Asn Trp Gly Gly Gly Arg Pro Asp Glu Lys Thr Pro Ser 
705                 710                 715                 720 


Ser Trp Asn Glu Asn Pro Ser Lys Asp Gln Gly Trp Gly Gly Gly Arg 
                725                 730                 735     


Gln Pro Asn Gln Gly Trp Ser Ser Gly Lys Asn Gly Trp Gly Glu Glu 
            740                 745                 750         


Val Asp Gln Thr Lys Asn Ser Asn Trp Glu Ser Ser Ala Ser Lys Pro 
        755                 760                 765             


Val Ser Gly Trp Gly Glu Gly Gly Gln Asn Glu Ile Gly Thr Trp Gly 
    770                 775                 780                 


Asn Gly Gly Asn Ala Ser Leu Ala Ser Lys Gly Gly Trp Glu Asp Cys 
785                 790                 795                 800 


Lys Arg Ser Pro Ala Trp Asn Glu Thr Gly Arg Gln Pro Asn Ser Trp 
                805                 810                 815     


Asn Lys Gln His Gln Gln Gln Gln Pro Pro Gln Gln Pro Pro Pro Pro 
            820                 825                 830         


Gln Pro Glu Ala Ser Gly Ser Trp Gly Gly Pro Pro Pro Pro Pro Pro 
        835                 840                 845             


Gly Asn Val Arg Pro Ser Asn Ser Ser Trp Ser Ser Gly Pro Gln Pro 
    850                 855                 860                 


Ala Thr Pro Lys Asp Glu Glu Pro Ser Gly Trp Glu Glu Pro Ser Pro 
865                 870                 875                 880 


Gln Ser Ile Ser Arg Lys Met Asp Ile Asp Asp Gly Thr Ser Ala Trp 
                885                 890                 895     


Gly Asp Pro Asn Ser Tyr Asn Tyr Lys Asn Val Asn Leu Trp Asp Lys 
            900                 905                 910         


Asn Ser Gln Gly Gly Pro Ala Pro Arg Glu Pro Asn Leu Pro Thr Pro 
        915                 920                 925             


Met Thr Ser Lys Ser Ala Ser Val Trp Ser Lys Ser Thr Pro Pro Ala 
    930                 935                 940                 


Pro Asp Asn Gly Thr Ser Ala Trp Gly Glu Pro Asn Glu Ser Ser Pro 
945                 950                 955                 960 


Gly Trp Gly Glu Met Asp Asp Thr Gly Ala Ser Thr Thr Gly Trp Gly 
                965                 970                 975     


Asn Thr Pro Ala Asn Ala Pro Asn Ala Met Lys Pro Asn Ser Lys Ser 
            980                 985                 990         


Met Gln Asp Gly Trp Gly Glu Ser  Asp Gly Pro Val Thr  Gly Ala Arg 
        995                 1000                 1005             


His Pro  Ser Trp Glu Glu Glu  Glu Asp Gly Gly Val  Trp Asn Thr 
    1010                 1015                 1020             


Thr Gly  Ser Gln Gly Ser Ala  Ser Ser His Asn Ser  Ala Ser Trp 
    1025                 1030                 1035             


Gly Gln  Gly Gly Lys Lys Gln  Met Lys Cys Ser Leu  Lys Gly Gly 
    1040                 1045                 1050             


Asn Asn  Asp Ser Trp Met Asn  Pro Leu Ala Lys Gln  Phe Ser Asn 
    1055                 1060                 1065             


Met Gly  Leu Leu Ser Gln Thr  Glu Asp Asn Pro Ser  Ser Lys Met 
    1070                 1075                 1080             


Asp Leu  Ser Val Gly Ser Leu  Ser Asp Lys Lys Phe  Asp Val Asp 
    1085                 1090                 1095             


Lys Arg  Ala Met Asn Leu Gly  Asp Phe Asn Asp Ile  Met Arg Lys 
    1100                 1105                 1110             


Asp Arg  Ser Gly Phe Arg Pro  Pro Asn Ser Lys Asp  Met Gly Thr 
    1115                 1120                 1125             


Thr Asp  Ser Gly Pro Tyr Phe  Glu Lys Leu Thr Leu  Pro Phe Ser 
    1130                 1135                 1140             


Asn Gln  Asp Gly Cys Leu Gly  Asp Glu Ala Pro Cys  Ser Pro Phe 
    1145                 1150                 1155             


Ser Pro  Ser Pro Ser Tyr Lys  Leu Ser Pro Ser Gly  Ser Thr Leu 
    1160                 1165                 1170             


Pro Asn  Val Ser Leu Gly Ala  Ile Gly Thr Gly Leu  Asn Pro Gln 
    1175                 1180                 1185             


Asn Phe  Ala Ala Arg Gln Gly  Gly Ser His Gly Leu  Phe Gly Asn 
    1190                 1195                 1200             


Ser Thr  Ala Gln Ser Arg Gly  Leu His Thr Pro Val  Gln Pro Leu 
    1205                 1210                 1215             


Asn Ser  Ser Pro Ser Leu Arg  Ala Gln Val Pro Pro  Gln Phe Ile 
    1220                 1225                 1230             


Ser Pro  Gln Val Ser Ala Ser  Met Leu Lys Gln Phe  Pro Asn Ser 
    1235                 1240                 1245             


Gly Leu  Ser Pro Gly Leu Phe  Asn Val Gly Pro Gln  Leu Ser Pro 
    1250                 1255                 1260             


Gln Gln  Ile Ala Met Leu Ser  Gln Leu Pro Gln Ile  Pro Gln Phe 
    1265                 1270                 1275             


Gln Leu  Ala Cys Gln Leu Leu  Leu Gln Gln Gln Gln  Gln Gln Gln 
    1280                 1285                 1290             


Leu Leu  Gln Asn Gln Arg Lys  Ile Ser Gln Ala Val  Arg Gln Gln 
    1295                 1300                 1305             


Gln Glu  Gln Gln Leu Ala Arg  Met Val Ser Ala Leu  Gln Gln Gln 
    1310                 1315                 1320             


Gln Gln  Gln Gln Gln Arg Gln  Pro Gly Met Lys His  Ser Pro Ser 
    1325                 1330                 1335             


His Pro  Val Gly Pro Lys Pro  His Leu Asp Asn Met  Val Pro Asn 
    1340                 1345                 1350             


Ala Leu  Asn Val Gly Leu Pro  Asp Leu Gln Thr Lys  Gly Pro Ile 
    1355                 1360                 1365             


Pro Gly  Tyr Gly Ser Gly Phe  Ser Ser Gly Gly Met  Asp Tyr Gly 
    1370                 1375                 1380             


Met Val  Gly Gly Lys Glu Ala  Gly Thr Glu Ser Arg  Phe Lys Gln 
    1385                 1390                 1395             


Trp Thr  Ser Met Met Glu Gly  Leu Pro Ser Val Ala  Thr Gln Glu 
    1400                 1405                 1410             


Ala Asn  Met His Lys Asn Gly  Ala Ile Val Ala Pro  Gly Lys Thr 
    1415                 1420                 1425             


Arg Gly  Gly Ser Pro Tyr Asn  Gln Phe Asp Ile Ile  Pro Gly Asp 
    1430                 1435                 1440             


Thr Leu  Gly Gly His Thr Gly  Pro Ala Gly Asp Ser  Trp Leu Pro 
    1445                 1450                 1455             


Ala Lys  Ser Pro Pro Thr Asn  Lys Ile Gly Ser Lys  Ser Ser Asn 
    1460                 1465                 1470             


Ala Ser  Trp Pro Pro Glu Phe  Gln Pro Gly Val Pro  Trp Lys Gly 
    1475                 1480                 1485             


Ile Gln  Asn Ile Asp Pro Glu  Ser Asp Pro Tyr Val  Thr Pro Gly 
    1490                 1495                 1500             


Ser Val  Leu Gly Gly Thr Ala  Thr Ser Pro Ile Val  Asp Thr Asp 
    1505                 1510                 1515             


His Gln  Leu Leu Arg Asp Asn  Thr Thr Gly Ser Asn  Ser Ser Leu 
    1520                 1525                 1530             


Asn Thr  Ser Leu Pro Ser Pro  Gly Ala Trp Pro Tyr  Ser Ala Ser 
    1535                 1540                 1545             


Asp Asn  Ser Phe Thr Asn Val  His Ser Thr Ser Ala  Lys Phe Pro 
    1550                 1555                 1560             


Asp Tyr  Lys Ser Thr Trp Ser  Pro Asp Pro Ile Gly  His Asn Pro 
    1565                 1570                 1575             


Thr His  Leu Ser Asn Lys Met  Trp Lys Asn His Ile  Ser Ser Arg 
    1580                 1585                 1590             


Asn Thr  Thr Pro Leu Pro Arg  Pro Pro Pro Gly Leu  Thr Asn Pro 
    1595                 1600                 1605             


Lys Pro  Ser Ser Pro Trp Ser  Ser Thr Ala Pro Arg  Ser Val Arg 
    1610                 1615                 1620             


Gly Trp  Gly Thr Gln Asp Ser  Arg Leu Ala Ser Ala  Ser Thr Trp 
    1625                 1630                 1635             


Ser Asp  Gly Gly Ser Val Arg  Pro Ser Tyr Trp Leu  Val Leu His 
    1640                 1645                 1650             


Asn Leu  Thr Pro Gln Ile Asp  Gly Ser Thr Leu Arg  Thr Ile Cys 
    1655                 1660                 1665             


Met Gln  His Gly Pro Leu Leu  Thr Phe His Leu Asn  Leu Thr Gln 
    1670                 1675                 1680             


Gly Thr  Ala Leu Ile Arg Tyr  Ser Thr Lys Gln Glu  Ala Ala Lys 
    1685                 1690                 1695             


Ala Gln  Thr Ala Leu His Met  Cys Val Leu Gly Asn  Thr Thr Ile 
    1700                 1705                 1710             


Leu Ala  Glu Phe Ala Thr Asp  Asp Glu Val Ser Arg  Phe Leu Ala 
    1715                 1720                 1725             


Gln Ala  Gln Pro Pro Thr Pro  Ala Ala Thr Pro Ser  Ala Pro Ala 
    1730                 1735                 1740             


Ala Gly  Trp Gln Ser Leu Glu  Thr Gly Gln Asn Gln  Ser Asp Pro 
    1745                 1750                 1755             


Val Gly  Pro Ala Leu Asn Leu  Phe Gly Gly Ser Thr  Gly Leu Gly 
    1760                 1765                 1770             


Gln Trp  Ser Ser Ser Ala Gly  Gly Ser Ser Gly Ala  Asp Leu Ala 
    1775                 1780                 1785             


Gly Ala  Ser Leu Trp Gly Pro  Pro Asn Tyr Ser Ser  Ser Leu Trp 
    1790                 1795                 1800             


Gly Val  Pro Thr Val Glu Asp  Pro His Arg Met Gly  Ser Pro Ala 
    1805                 1810                 1815             


Pro Leu  Leu Pro Gly Asp Leu  Leu Gly Gly Gly Ser  Asp Ser Ile 
    1820                 1825                 1830             


<210>  211
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Ser Lys Ile Ser Glu Ala Val Lys Arg Ala Arg Ala Ala Phe Ser 
1               5                   10                  15      


Ser Gly Arg Thr Arg Pro Leu Gln Phe Arg Ile Gln Gln Leu Glu Ala 
            20                  25                  30          


Leu Gln Arg Leu Ile Gln Glu Gln Glu Gln Glu Leu Val Gly Ala Leu 
        35                  40                  45              


Ala Ala Asp Leu His Lys Asn Glu Trp Asn Ala Tyr Tyr Glu Glu Val 
    50                  55                  60                  


Val Tyr Val Leu Glu Glu Ile Glu Tyr Met Ile Gln Lys Leu Pro Glu 
65                  70                  75                  80  


Trp Ala Ala Asp Glu Pro Val Glu Lys Thr Pro Gln Thr Gln Gln Asp 
                85                  90                  95      


Glu Leu Tyr Ile His Ser Glu Pro Leu Gly Val Val Leu Val Ile Gly 
            100                 105                 110         


Thr Trp Asn Tyr Pro Phe Asn Leu Thr Ile Gln Pro Met Val Gly Ala 
        115                 120                 125             


Ile Ala Ala Gly Asn Ser Val Val Leu Lys Pro Ser Glu Leu Ser Glu 
    130                 135                 140                 


Asn Met Ala Ser Leu Leu Ala Thr Ile Ile Pro Gln Tyr Leu Asp Lys 
145                 150                 155                 160 


Asp Leu Tyr Pro Val Ile Asn Gly Gly Val Pro Glu Thr Thr Glu Leu 
                165                 170                 175     


Leu Lys Glu Arg Phe Asp His Ile Leu Tyr Thr Gly Ser Thr Gly Val 
            180                 185                 190         


Gly Lys Ile Ile Met Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr 
        195                 200                 205             


Leu Glu Leu Gly Gly Lys Ser Pro Cys Tyr Val Asp Lys Asn Cys Asp 
    210                 215                 220                 


Leu Asp Val Ala Cys Arg Arg Ile Ala Trp Gly Lys Phe Met Asn Ser 
225                 230                 235                 240 


Gly Gln Thr Cys Val Ala Pro Asp Tyr Ile Leu Cys Asp Pro Ser Ile 
                245                 250                 255     


Gln Asn Gln Ile Val Glu Lys Leu Lys Lys Ser Leu Lys Glu Phe Tyr 
            260                 265                 270         


Gly Glu Asp Ala Lys Lys Ser Arg Asp Tyr Gly Arg Ile Ile Ser Ala 
        275                 280                 285             


Arg His Phe Gln Arg Val Met Gly Leu Ile Glu Gly Gln Lys Val Ala 
    290                 295                 300                 


Tyr Gly Gly Thr Gly Asp Ala Ala Thr Arg Tyr Ile Ala Pro Thr Ile 
305                 310                 315                 320 


Leu Thr Asp Val Asp Pro Gln Ser Pro Val Met Gln Glu Glu Ile Phe 
                325                 330                 335     


Gly Pro Val Leu Pro Ile Val Cys Val Arg Ser Leu Glu Glu Ala Ile 
            340                 345                 350         


Gln Phe Ile Asn Gln Arg Glu Lys Pro Leu Ala Leu Tyr Met Phe Ser 
        355                 360                 365             


Ser Asn Asp Lys Val Ile Lys Lys Met Ile Ala Glu Thr Ser Ser Gly 
    370                 375                 380                 


Gly Val Ala Ala Asn Asp Val Ile Val His Ile Thr Leu His Ser Leu 
385                 390                 395                 400 


Pro Phe Gly Gly Val Gly Asn Ser Gly Met Gly Ser Tyr His Gly Lys 
                405                 410                 415     


Lys Ser Phe Glu Thr Phe Ser His Arg Arg Ser Cys Leu Val Arg Pro 
            420                 425                 430         


Leu Met Asn Asp Glu Gly Leu Lys Val Arg Tyr Pro Pro Ser Pro Ala 
        435                 440                 445             


Lys Met Thr Gln His 
    450             


<210>  212
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ala Val Gln Ile Ser Lys Lys Arg Lys Phe Val Ala Asp Gly Ile 
1               5                   10                  15      


Phe Lys Ala Glu Leu Asn Glu Phe Leu Thr Arg Glu Leu Ala Glu Asp 
            20                  25                  30          


Gly Tyr Ser Gly Val Glu Val Arg Val Thr Pro Thr Arg Thr Glu Ile 
        35                  40                  45              


Ile Ile Leu Ala Thr Arg Thr Gln Asn Val Leu Gly Glu Lys Gly Arg 
    50                  55                  60                  


Arg Ile Arg Glu Leu Thr Ala Val Val Gln Lys Arg Phe Gly Phe Pro 
65                  70                  75                  80  


Glu Gly Ser Val Glu Leu Tyr Ala Glu Lys Val Ala Thr Arg Gly Leu 
                85                  90                  95      


Cys Ala Ile Ala Gln Ala Glu Ser Leu Arg Tyr Lys Leu Leu Gly Gly 
            100                 105                 110         


Leu Ala Val Arg Arg Ala Cys Tyr Gly Val Leu Arg Phe Ile Met Glu 
        115                 120                 125             


Ser Gly Ala Lys Gly Cys Glu Val Val Val Ser Gly Lys Leu Arg Gly 
    130                 135                 140                 


Gln Arg Ala Lys Ser Met Lys Phe Val Asp Gly Leu Met Ile His Ser 
145                 150                 155                 160 


Gly Asp Pro Val Asn Tyr Tyr Val Asp Thr Ala Val Arg His Val Leu 
                165                 170                 175     


Leu Arg Gln Gly Val Leu Gly Ile Lys Val Lys Ile Met Leu Pro Trp 
            180                 185                 190         


Asp Pro Thr Gly Lys Ile Gly Pro Lys Lys Pro Leu Pro Asp His Val 
        195                 200                 205             


Ser Ile Val Glu Pro Lys Asp Glu Ile Leu Pro Thr Thr Pro Ile Ser 
    210                 215                 220                 


Glu Gln Lys Gly Gly Lys Pro Glu Pro Pro Ala Met Pro Gln Pro Val 
225                 230                 235                 240 


Pro Thr Ala 
            


<210>  213
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Glu Leu Glu Val Arg Arg Val Arg Gln Ala Phe Leu Ser Gly Arg 
1               5                   10                  15      


Ser Arg Pro Leu Arg Phe Arg Leu Gln Gln Leu Glu Ala Leu Arg Arg 
            20                  25                  30          


Met Val Gln Glu Arg Glu Lys Asp Ile Leu Thr Ala Ile Ala Ala Asp 
        35                  40                  45              


Leu Cys Lys Ser Glu Phe Asn Val Tyr Ser Gln Glu Val Ile Thr Val 
    50                  55                  60                  


Leu Gly Glu Ile Asp Phe Met Leu Glu Asn Leu Pro Glu Trp Val Thr 
65                  70                  75                  80  


Ala Lys Pro Val Lys Lys Asn Val Leu Thr Met Leu Asp Glu Ala Tyr 
                85                  90                  95      


Ile Gln Pro Gln Pro Leu Gly Val Val Leu Ile Ile Gly Ala Trp Asn 
            100                 105                 110         


Tyr Pro Phe Val Leu Thr Ile Gln Pro Leu Ile Gly Ala Ile Ala Ala 
        115                 120                 125             


Gly Asn Ala Val Ile Ile Lys Pro Ser Glu Leu Ser Glu Asn Thr Ala 
    130                 135                 140                 


Lys Ile Leu Ala Lys Leu Leu Pro Gln Tyr Leu Asp Gln Asp Leu Tyr 
145                 150                 155                 160 


Ile Val Ile Asn Gly Gly Val Glu Glu Thr Thr Glu Leu Leu Lys Gln 
                165                 170                 175     


Arg Phe Asp His Ile Phe Tyr Thr Gly Asn Thr Ala Val Gly Lys Ile 
            180                 185                 190         


Val Met Glu Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu 
        195                 200                 205             


Gly Gly Lys Ser Pro Cys Tyr Ile Asp Lys Asp Cys Asp Leu Asp Ile 
    210                 215                 220                 


Val Cys Arg Arg Ile Thr Trp Gly Lys Tyr Met Asn Cys Gly Gln Thr 
225                 230                 235                 240 


Cys Ile Ala Pro Asp Tyr Ile Leu Cys Glu Ala Ser Leu Gln Asn Gln 
                245                 250                 255     


Ile Val Trp Lys Ile Lys Glu Thr Val Lys Glu Phe Tyr Gly Glu Asn 
            260                 265                 270         


Ile Lys Glu Ser Pro Asp Tyr Glu Arg Ile Ile Asn Leu Arg His Phe 
        275                 280                 285             


Lys Arg Ile Leu Ser Leu Leu Glu Gly Gln Lys Ile Ala Phe Gly Gly 
    290                 295                 300                 


Glu Thr Asp Glu Ala Thr Arg Tyr Ile Ala Pro Thr Val Leu Thr Asp 
305                 310                 315                 320 


Val Asp Pro Lys Thr Lys Val Met Gln Glu Glu Ile Phe Gly Pro Ile 
                325                 330                 335     


Leu Pro Ile Val Pro Val Lys Asn Val Asp Glu Ala Ile Asn Phe Ile 
            340                 345                 350         


Asn Glu Arg Glu Lys Pro Leu Ala Leu Tyr Val Phe Ser His Asn His 
        355                 360                 365             


Lys Leu Ile Lys Arg Met Ile Asp Glu Thr Ser Ser Gly Gly Val Thr 
    370                 375                 380                 


Gly Asn Asp Val Ile Met His Phe Thr Leu Asn Ser Phe Pro Phe Gly 
385                 390                 395                 400 


Gly Val Gly Ser Ser Gly Met Gly Ala Tyr His Gly Lys His Ser Phe 
                405                 410                 415     


Asp Thr Phe Ser His Gln Arg Pro Cys Leu Leu Lys Ser Leu Lys Arg 
            420                 425                 430         


Glu Gly Ala Asn Lys Leu Arg Tyr Pro Pro Asn Ser Gln Ser Lys Val 
        435                 440                 445             


Asp Trp Gly Lys Phe Phe Leu Leu Lys Arg Phe Asn Lys Glu Lys Leu 
    450                 455                 460                 


Gly Leu Leu Leu Leu Thr Phe Leu Gly Ile Val Ala Ala Val Leu Val 
465                 470                 475                 480 


Lys Ala Glu Tyr Tyr 
                485 


<210>  214
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
            20                  25                  30          


Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
        35                  40                  45              


Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
    50                  55                  60                  


Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
65                  70                  75                  80  


His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                85                  90                  95      


Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
            100                 105                 110         


Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
        115                 120                 125             


Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
    130                 135                 140                 


Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
145                 150                 155                 160 


Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                165                 170                 175     


Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
            180                 185                 190         


Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
        195                 200                 205             


Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
    210                 215                 220                 


Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
225                 230                 235                 240 


Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                245                 250                 255     


Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
            260                 265                 270         


Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
        275                 280                 285             


Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
    290                 295                 300                 


Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
305                 310                 315                 320 


Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                325                 330             


<210>  215
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Phe Arg Gln Asp His Pro 
            260                 265                 270         


Ser Ser Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro 
        275                 280                 285             


Gly Glu Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly Arg 
    290                 295                 300                 


Gly Gly Phe Asp Arg Gly Gly Met Ser Arg Gly Gly Arg Gly Gly Gly 
305                 310                 315                 320 


Arg Gly Gly Met Gly Ser Ala Gly Glu Arg Gly Gly Phe Asn Lys Pro 
                325                 330                 335     


Gly Gly Pro Met Asp Glu Gly Pro Asp Leu Asp Leu Gly Pro Pro Val 
            340                 345                 350         


Asp Pro Asp Glu Asp Ser Asp Asn Ser Ala Ile Tyr Val Gln Gly Leu 
        355                 360                 365             


Asn Asp Ser Val Thr Leu Asp Asp Leu Ala Asp Phe Phe Lys Gln Cys 
    370                 375                 380                 


Gly Val Val Lys Met Asn Lys Arg Thr Gly Gln Pro Met Ile His Ile 
385                 390                 395                 400 


Tyr Leu Asp Lys Glu Thr Gly Lys Pro Lys Gly Asp Ala Thr Val Ser 
                405                 410                 415     


Tyr Glu Asp Pro Pro Thr Ala Lys Ala Ala Val Glu Trp Phe Asp Gly 
            420                 425                 430         


Lys Asp Phe Gln Gly Ser Lys Leu Lys Val Ser Leu Ala Arg Lys Lys 
        435                 440                 445             


Pro Pro Met Asn Ser Met Arg Gly Gly Leu Pro Pro Arg Glu Gly Arg 
    450                 455                 460                 


Gly Met Pro Pro Pro Leu Arg Gly Gly Pro Gly Gly Pro Gly Gly Pro 
465                 470                 475                 480 


Gly Gly Pro Met Gly Arg Met Gly Gly Arg Gly Gly Asp Arg Gly Gly 
                485                 490                 495     


Phe Pro Pro Arg Gly Pro Arg Gly Ser Arg Gly Asn Pro Ser Gly Gly 
            500                 505                 510         


Gly Asn Val Gln His Arg Ala Gly Asp Trp Gln Cys Pro Asn Pro Gly 
        515                 520                 525             


Cys Gly Asn Gln Asn Phe Ala Trp Arg Thr Glu Cys Asn Gln Cys Lys 
    530                 535                 540                 


Ala Pro Lys Pro Glu Gly Phe Leu Pro Pro Pro Phe Pro Pro Pro Gly 
545                 550                 555                 560 


Gly Asp Arg Gly Arg Gly Gly Pro Gly Gly Met Arg Gly Gly Arg Gly 
                565                 570                 575     


Gly Leu Met Asp Arg Gly Gly Pro Gly Gly Met Phe Arg Gly Gly Arg 
            580                 585                 590         


Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Met Asp Arg Gly 
        595                 600                 605             


Gly Phe Gly Gly Gly Arg Arg Gly Gly Pro Gly Gly Pro Pro Gly Pro 
    610                 615                 620                 


Leu Met Glu Gln Met Gly Gly Arg Arg Gly Gly Arg Gly Gly Pro Gly 
625                 630                 635                 640 


Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg Pro Tyr 
                645                 650                 655     


<210>  216
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ala Gly Gly Lys Ala Gly Lys Asp Ser Gly Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Val Ser Arg Ser Gln Arg Ala Gly Leu Gln Phe Pro Val Gly Arg 
            20                  25                  30          


Ile His Arg His Leu Lys Thr Arg Thr Thr Ser His Gly Arg Val Gly 
        35                  40                  45              


Ala Thr Ala Ala Val Tyr Ser Ala Ala Ile Leu Glu Tyr Leu Thr Ala 
    50                  55                  60                  


Glu Val Leu Glu Leu Ala Gly Asn Ala Ser Lys Asp Leu Lys Val Lys 
65                  70                  75                  80  


Arg Ile Thr Pro Arg His Leu Gln Leu Ala Ile Arg Gly Asp Glu Glu 
                85                  90                  95      


Leu Asp Ser Leu Ile Lys Ala Thr Ile Ala Gly Gly Gly Val Ile Pro 
            100                 105                 110         


His Ile His Lys Ser Leu Ile Gly Lys Lys Gly Gln Gln Lys Thr Ala 
        115                 120                 125             


<210>  217
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ala Thr Glu His Val Asn Gly Asn Gly Thr Glu Glu Pro Met Asp 
1               5                   10                  15      


Thr Thr Ser Ala Val Ile His Ser Glu Asn Phe Gln Thr Leu Leu Asp 
            20                  25                  30          


Ala Gly Leu Pro Gln Lys Val Ala Glu Lys Leu Asp Glu Ile Tyr Val 
        35                  40                  45              


Ala Gly Leu Val Ala His Ser Asp Leu Asp Glu Arg Ala Ile Glu Ala 
    50                  55                  60                  


Leu Lys Glu Phe Asn Glu Asp Gly Ala Leu Ala Val Leu Gln Gln Phe 
65                  70                  75                  80  


Lys Asp Ser Asp Leu Ser His Val Gln Asn Lys Ser Ala Phe Leu Cys 
                85                  90                  95      


Gly Val Met Lys Thr Tyr Arg Gln Arg Glu Lys Gln Gly Thr Lys Val 
            100                 105                 110         


Ala Asp Ser Ser Lys Gly Pro Asp Glu Ala Lys Ile Lys Ala Leu Leu 
        115                 120                 125             


Glu Arg Thr Gly Tyr Thr Leu Asp Val Thr Thr Gly Gln Arg Lys Tyr 
    130                 135                 140                 


Gly Gly Pro Pro Pro Asp Ser Val Tyr Ser Gly Gln Gln Pro Ser Val 
145                 150                 155                 160 


Gly Thr Glu Ile Phe Val Gly Lys Ile Pro Arg Asp Leu Phe Glu Asp 
                165                 170                 175     


Glu Leu Val Pro Leu Phe Glu Lys Ala Gly Pro Ile Trp Asp Leu Arg 
            180                 185                 190         


Leu Met Met Asp Pro Leu Thr Gly Leu Asn Arg Gly Tyr Ala Phe Val 
        195                 200                 205             


Thr Phe Cys Thr Lys Glu Ala Ala Gln Glu Ala Val Lys Leu Tyr Asn 
    210                 215                 220                 


Asn His Glu Ile Arg Ser Gly Lys His Ile Gly Val Cys Ile Ser Val 
225                 230                 235                 240 


Ala Asn Asn Arg Leu Phe Val Gly Ser Ile Pro Lys Ser Lys Thr Lys 
                245                 250                 255     


Glu Gln Ile Leu Glu Glu Phe Ser Lys Val Thr Glu Gly Leu Thr Asp 
            260                 265                 270         


Val Ile Leu Tyr His Gln Pro Asp Asp Lys Lys Lys Asn Arg Gly Phe 
        275                 280                 285             


Cys Phe Leu Glu Tyr Glu Asp His Lys Thr Ala Ala Gln Ala Arg Arg 
    290                 295                 300                 


Arg Leu Met Ser Gly Lys Val Lys Val Trp Gly Asn Val Gly Thr Val 
305                 310                 315                 320 


Glu Trp Ala Asp Pro Ile Glu Asp Pro Asp Pro Glu Val Met Ala Lys 
                325                 330                 335     


Val Lys Val Leu Phe Val Arg Asn Leu Ala Asn Thr Val Thr Glu Glu 
            340                 345                 350         


Ile Leu Glu Lys Ala Phe Ser Gln Phe Gly Lys Leu Glu Arg Val Lys 
        355                 360                 365             


Lys Leu Lys Asp Tyr Ala Phe Ile His Phe Asp Glu Arg Asp Gly Ala 
    370                 375                 380                 


Val Lys Ala Met Glu Glu Met Asn Gly Lys Asp Leu Glu Gly Glu Asn 
385                 390                 395                 400 


Ile Glu Ile Val Phe Ala Lys Pro Pro Asp Gln Lys Arg Lys Glu Arg 
                405                 410                 415     


Lys Ala Gln Arg Gln Ala Ala Lys Asn Gln Met Tyr Asp Asp Tyr Tyr 
            420                 425                 430         


Tyr Tyr Gly Pro Pro His Met Pro Pro Pro Thr Arg Gly Arg Gly Arg 
        435                 440                 445             


Gly Gly Arg Gly Gly Tyr Gly Tyr Pro Pro Asp Tyr Tyr Gly Tyr Glu 
    450                 455                 460                 


Asp Tyr Tyr Asp Tyr Tyr Gly Tyr Asp Tyr His Asn Tyr Arg Gly Gly 
465                 470                 475                 480 


Tyr Glu Asp Pro Tyr Tyr Gly Tyr Glu Asp Phe Gln Val Gly Ala Arg 
                485                 490                 495     


Gly Arg Gly Gly Arg Gly Ala Arg Gly Ala Ala Pro Ser Arg Gly Arg 
            500                 505                 510         


Gly Ala Ala Pro Pro Arg Gly Arg Ala Gly Tyr Ser Gln Arg Gly Gly 
        515                 520                 525             


Pro Gly Ser Ala Arg Gly Val Arg Gly Ala Arg Gly Gly Ala Gln Gln 
    530                 535                 540                 


Gln Arg Gly Arg Gly Val Arg Gly Ala Arg Gly Gly Arg Gly Gly Asn 
545                 550                 555                 560 


Val Gly Gly Lys Arg Lys Ala Asp Gly Tyr Asn Gln Pro Asp Ser Lys 
                565                 570                 575     


Arg Arg Gln Thr Asn Asn Gln Asn Trp Gly Ser Gln Pro Ile Ala Gln 
            580                 585                 590         


Gln Pro Leu Gln Gly Gly Asp His Ser Gly Asn Tyr Gly Tyr Lys Ser 
        595                 600                 605             


Glu Asn Gln Glu Phe Tyr Gln Asp Thr Phe Gly Gln Gln Trp Lys 
    610                 615                 620             


<210>  218
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ser Val Gly Phe Ile Gly Ala Gly Gln Leu Ala Tyr Ala Leu Ala 
1               5                   10                  15      


Arg Gly Phe Thr Ala Ala Gly Ile Leu Ser Ala His Lys Ile Ile Ala 
            20                  25                  30          


Ser Ser Pro Glu Met Asn Leu Pro Thr Val Ser Ala Leu Arg Lys Met 
        35                  40                  45              


Gly Val Asn Leu Thr Arg Ser Asn Lys Glu Thr Val Lys His Ser Asp 
    50                  55                  60                  


Val Leu Phe Leu Ala Val Lys Pro His Ile Ile Pro Phe Ile Leu Asp 
65                  70                  75                  80  


Glu Ile Gly Ala Asp Val Gln Ala Arg His Ile Val Val Ser Cys Ala 
                85                  90                  95      


Ala Gly Val Thr Ile Ser Ser Val Glu Lys Lys Leu Met Ala Phe Gln 
            100                 105                 110         


Pro Ala Pro Lys Val Ile Arg Cys Met Thr Asn Thr Pro Val Val Val 
        115                 120                 125             


Gln Glu Gly Ala Thr Val Tyr Ala Thr Gly Thr His Ala Leu Val Glu 
    130                 135                 140                 


Asp Gly Gln Leu Leu Glu Gln Leu Met Ser Ser Val Gly Phe Cys Thr 
145                 150                 155                 160 


Glu Val Glu Glu Asp Leu Ile Asp Ala Val Thr Gly Leu Ser Gly Ser 
                165                 170                 175     


Gly Pro Ala Tyr Ala Phe Met Ala Leu Asp Ala Leu Ala Asp Gly Gly 
            180                 185                 190         


Val Lys Met Gly Leu Pro Arg Arg Leu Ala Ile Gln Leu Gly Ala Gln 
        195                 200                 205             


Ala Leu Leu Gly Ala Ala Lys Met Leu Leu Asp Ser Glu Gln His Pro 
    210                 215                 220                 


Cys Gln Leu Lys Asp Asn Val Cys Ser Pro Gly Gly Ala Thr Ile His 
225                 230                 235                 240 


Ala Leu His Phe Leu Glu Ser Gly Gly Phe Arg Ser Leu Leu Ile Asn 
                245                 250                 255     


Ala Val Glu Ala Ser Cys Ile Arg Thr Arg Glu Leu Gln Ser Met Ala 
            260                 265                 270         


Asp Gln Glu Lys Ile Ser Pro Ala Ala Leu Lys Lys Thr Leu Leu Asp 
        275                 280                 285             


Arg Val Lys Leu Glu Ser Pro Thr Val Ser Thr Leu Thr Pro Ser Ser 
    290                 295                 300                 


Pro Gly Lys Leu Leu Thr Arg Ser Leu Ala Leu Gly Gly Lys Lys Asp 
305                 310                 315                 320 


<210>  219
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
1               5                   10                  15      


Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
            20                  25                  30          


Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
        35                  40                  45              


Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
    50                  55                  60                  


Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
65                  70                  75                  80  


Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                85                  90                  95      


Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
            100                 105                 110         


Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
        115                 120                 125             


Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
    130                 135                 140                 


Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
145                 150                 155                 160 


Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                165                 170                 175     


Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
            180                 185                 190         


Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys 
        195                 200                 205             


Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile 
    210                 215                 220                 


Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys 
225                 230                 235                 240 


Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn 
                245                 250                 255     


Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln 
            260                 265                 270         


<210>  220
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Lys Ile Glu Glu Val Lys Ser Thr Thr Lys Thr Gln Arg Ile Ala 
1               5                   10                  15      


Ser His Ser His Val Lys Gly Leu Gly Leu Asp Glu Ser Gly Leu Ala 
            20                  25                  30          


Lys Gln Ala Ala Ser Gly Leu Val Gly Gln Glu Asn Ala Arg Glu Ala 
        35                  40                  45              


Cys Gly Val Ile Val Glu Leu Ile Lys Ser Lys Lys Met Ala Gly Arg 
    50                  55                  60                  


Ala Val Leu Leu Ala Gly Pro Pro Gly Thr Gly Lys Thr Ala Leu Ala 
65                  70                  75                  80  


Leu Ala Ile Ala Gln Glu Leu Gly Ser Lys Val Pro Phe Cys Pro Met 
                85                  90                  95      


Val Gly Ser Glu Val Tyr Ser Thr Glu Ile Lys Lys Thr Glu Val Leu 
            100                 105                 110         


Met Glu Asn Phe Arg Arg Ala Ile Gly Leu Arg Ile Lys Glu Thr Lys 
        115                 120                 125             


Glu Val Tyr Glu Gly Glu Val Thr Glu Leu Thr Pro Cys Glu Thr Glu 
    130                 135                 140                 


Asn Pro Met Gly Gly Tyr Gly Lys Thr Ile Ser His Val Ile Ile Gly 
145                 150                 155                 160 


Leu Lys Thr Ala Lys Gly Thr Lys Gln Leu Lys Leu Asp Pro Ser Ile 
                165                 170                 175     


Phe Glu Ser Leu Gln Lys Glu Arg Val Glu Ala Gly Asp Val Ile Tyr 
            180                 185                 190         


Ile Glu Ala Asn Ser Gly Ala Val Lys Arg Gln Gly Arg Cys Asp Thr 
        195                 200                 205             


Tyr Ala Thr Glu Phe Asp Leu Glu Ala Glu Glu Tyr Val Pro Leu Pro 
    210                 215                 220                 


Lys Gly Asp Val His Lys Lys Lys Glu Ile Ile Gln Asp Val Thr Leu 
225                 230                 235                 240 


His Asp Leu Asp Val Ala Asn Ala Arg Pro Gln Gly Gly Gln Asp Ile 
                245                 250                 255     


Leu Ser Met Met Gly Gln Leu Met Lys Pro Lys Lys Thr Glu Ile Thr 
            260                 265                 270         


Asp Lys Leu Arg Gly Glu Ile Asn Lys Val Val Asn Lys Tyr Ile Asp 
        275                 280                 285             


Gln Gly Ile Ala Glu Leu Val Pro Gly Val Leu Phe Val Asp Glu Val 
    290                 295                 300                 


His Met Leu Asp Ile Glu Cys Phe Thr Tyr Leu His Arg Ala Leu Glu 
305                 310                 315                 320 


Ser Ser Ile Ala Pro Ile Val Ile Phe Ala Ser Asn Arg Gly Asn Cys 
                325                 330                 335     


Val Ile Arg Gly Thr Glu Asp Ile Thr Ser Pro His Gly Ile Pro Leu 
            340                 345                 350         


Asp Leu Leu Asp Arg Val Met Ile Ile Arg Thr Met Leu Tyr Thr Pro 
        355                 360                 365             


Gln Glu Met Lys Gln Ile Ile Lys Ile Arg Ala Gln Thr Glu Gly Ile 
    370                 375                 380                 


Asn Ile Ser Glu Glu Ala Leu Asn His Leu Gly Glu Ile Gly Thr Lys 
385                 390                 395                 400 


Thr Thr Leu Arg Tyr Ser Val Gln Leu Leu Thr Pro Ala Asn Leu Leu 
                405                 410                 415     


Ala Lys Ile Asn Gly Lys Asp Ser Ile Glu Lys Glu His Val Glu Glu 
            420                 425                 430         


Ile Ser Glu Leu Phe Tyr Asp Ala Lys Ser Ser Ala Lys Ile Leu Ala 
        435                 440                 445             


Asp Gln Gln Asp Lys Tyr Met Lys 
    450                 455     


<210>  221
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala 
        675                 680                 685         


<210>  222
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Met Thr Ser Val Ser Ser Asp His Cys Arg Gly Ala Arg Glu Lys 
1               5                   10                  15      


Pro Gln Ile Ser Ala Ala Gln Ser Thr Gln Pro Gln Lys Gln Val Val 
            20                  25                  30          


Gln Ala Thr Ala Glu Gln Met Arg Leu Ala Gln Val Ile Phe Asp Lys 
        35                  40                  45              


Asn Asp Ser Asp Phe Glu Ala Lys Val Lys Gln Leu Met Glu Val Thr 
    50                  55                  60                  


Gly Lys Asn Gln Asp Glu Cys Ile Val Ala Leu His Asp Cys Asn Gly 
65                  70                  75                  80  


Asp Val Asn Lys Ala Ile Asn Ile Leu Leu Glu Gly Asn Ser Asp Thr 
                85                  90                  95      


Thr Ser Trp Glu Thr Val Gly Cys Lys Lys Lys Asn Phe Ala Lys Glu 
            100                 105                 110         


Asn Ser Glu Asn Lys Glu Asn Arg Glu Lys Lys Ser Glu Lys Glu Ser 
        115                 120                 125             


Ser Arg Gly Arg Gly Asn Asn Asn Arg Lys Gly Arg Gly Gly Asn Arg 
    130                 135                 140                 


Gly Arg Glu Phe Arg Gly Glu Glu Asn Gly Ile Asp Cys Asn Gln Val 
145                 150                 155                 160 


Asp Lys Pro Ser Asp Arg Gly Lys Arg Ala Arg Gly Arg Gly Phe Gly 
                165                 170                 175     


Arg Gly Arg Gly Arg Gly Ala Gly Arg Phe Ser Thr Gln Gly Met Gly 
            180                 185                 190         


Thr Phe Asn Pro Ala Asp Tyr Ser Asp Ser Thr Ser Thr Asp Val Cys 
        195                 200                 205             


Gly Thr Lys Leu Val Val Trp Glu Ala Ala Gln Asn Gly Ala Asp Glu 
    210                 215                 220                 


Gly Thr Glu Leu Ala Ser Asn Thr His Asn Ile Ala Gln Asp Leu Ser 
225                 230                 235                 240 


Asn Lys Ser Ser Tyr Gly Leu Lys Gly Ala Trp Lys Asn Ser Val Glu 
                245                 250                 255     


Glu Trp Thr Thr Glu Asp Trp Thr Glu Asp Leu Ser Glu Thr Lys Val 
            260                 265                 270         


Phe Thr Ala Ser Ser Ala Pro Ala Glu Asn His Ile Leu Pro Gly Gln 
        275                 280                 285             


Ser Ile Asp Leu Val Ala Leu Leu Gln Lys Pro Val Pro His Ser Gln 
    290                 295                 300                 


Ala Ser Glu Ala Asn Ser Phe Glu Thr Ser Gln Gln Gln Gly Phe Gly 
305                 310                 315                 320 


Gln Ala Leu Val Phe Thr Asn Ser Gln His Asn Asn Gln Met Ala Pro 
                325                 330                 335     


Gly Thr Gly Ser Ser Thr Ala Val Asn Ser Cys Ser Pro Gln Ser Leu 
            340                 345                 350         


Ser Ser Val Leu Gly Ser Gly Phe Gly Glu Leu Ala Pro Pro Lys Met 
        355                 360                 365             


Ala Asn Ile Thr Ser Ser Gln Ile Leu Asp Gln Leu Lys Ala Pro Ser 
    370                 375                 380                 


Leu Gly Gln Phe Thr Thr Thr Pro Ser Thr Gln Gln Asn Ser Thr Ser 
385                 390                 395                 400 


His Pro Thr Thr Thr Thr Ser Trp Asp Leu Lys Pro Pro Thr Ser Gln 
                405                 410                 415     


Ser Ser Val Leu Ser His Leu Asp Phe Lys Ser Gln Pro Glu Pro Ser 
            420                 425                 430         


Pro Val Leu Ser Gln Leu Ser Gln Arg Gln Gln His Gln Ser Gln Ala 
        435                 440                 445             


Val Thr Val Pro Pro Pro Gly Leu Glu Ser Phe Pro Ser Gln Ala Lys 
    450                 455                 460                 


Leu Arg Glu Ser Thr Pro Gly Asp Ser Pro Ser Thr Val Asn Lys Leu 
465                 470                 475                 480 


Leu Gln Leu Pro Ser Thr Thr Ile Glu Asn Ile Ser Val Ser Val His 
                485                 490                 495     


Gln Pro Gln Pro Lys His Ile Lys Leu Ala Lys Arg Arg Ile Pro Pro 
            500                 505                 510         


Ala Ser Lys Ile Pro Ala Ser Ala Val Glu Met Pro Gly Ser Ala Asp 
        515                 520                 525             


Val Thr Gly Leu Asn Val Gln Phe Gly Ala Leu Glu Phe Gly Ser Glu 
    530                 535                 540                 


Pro Ser Leu Ser Glu Phe Gly Ser Ala Pro Ser Ser Glu Asn Ser Asn 
545                 550                 555                 560 


Gln Ile Pro Ile Ser Leu Tyr Ser Lys Ser Leu Ser Glu Pro Leu Asn 
                565                 570                 575     


Thr Ser Leu Ser Met Thr Ser Ala Val Gln Asn Ser Thr Tyr Thr Thr 
            580                 585                 590         


Ser Val Ile Thr Ser Cys Ser Leu Thr Ser Ser Ser Leu Asn Ser Ala 
        595                 600                 605             


Ser Pro Val Ala Met Ser Ser Ser Tyr Asp Gln Ser Ser Val His Asn 
    610                 615                 620                 


Arg Ile Pro Tyr Gln Ser Pro Val Ser Ser Ser Glu Ser Ala Pro Gly 
625                 630                 635                 640 


Thr Ile Met Asn Gly His Gly Gly Gly Arg Ser Gln Gln Thr Leu Asp 
                645                 650                 655     


Thr Pro Lys Thr Thr Gly Pro Pro Ser Ala Leu Pro Ser Val Ser Ser 
            660                 665                 670         


Leu Pro Ser Thr Thr Ser Cys Thr Ala Leu Leu Pro Ser Thr Ser Gln 
        675                 680                 685             


His Thr Gly Asp Leu Thr Ser Ser Pro Leu Ser Gln Leu Ser Ser Ser 
    690                 695                 700                 


Leu Ser Ser His Gln Ser Ser Leu Ser Ala His Ala Ala Leu Ser Ser 
705                 710                 715                 720 


Ser Thr Ser His Thr His Ala Ser Val Glu Ser Ala Ser Ser His Gln 
                725                 730                 735     


Ser Ser Ala Thr Phe Ser Thr Ala Ala Thr Ser Val Ser Ser Ser Ala 
            740                 745                 750         


Ser Ser Gly Ala Ser Leu Ser Ser Ser Met Asn Thr Ala Asn Ser Leu 
        755                 760                 765             


Cys Leu Gly Gly Thr Pro Ala Ser Ala Ser Ser Ser Ser Ser Arg Ala 
    770                 775                 780                 


Ala Pro Leu Val Thr Ser Gly Lys Ala Pro Pro Asn Leu Pro Gln Gly 
785                 790                 795                 800 


Val Pro Pro Leu Leu His Asn Gln Tyr Leu Val Gly Pro Gly Gly Leu 
                805                 810                 815     


Leu Pro Ala Tyr Pro Ile Tyr Gly Tyr Asp Glu Leu Gln Met Leu Gln 
            820                 825                 830         


Ser Arg Leu Pro Val Asp Tyr Tyr Gly Ile Pro Phe Ala Ala Pro Thr 
        835                 840                 845             


Ala Leu Ala Ser Arg Asp Gly Ser Leu Ala Asn Asn Pro Tyr Pro Gly 
    850                 855                 860                 


Asp Val Thr Lys Phe Gly Arg Gly Asp Ser Ala Ser Pro Ala Pro Ala 
865                 870                 875                 880 


Thr Thr Pro Ala Gln Pro Gln Gln Ser Gln Ser Gln Thr His His Thr 
                885                 890                 895     


Ala Gln Gln Pro Phe Val Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr 
            900                 905                 910         


Thr Gly Leu Pro Tyr Tyr Thr Gly Met Pro Ser Ala Phe Gln Tyr Gly 
        915                 920                 925             


Pro Thr Met Phe Val Pro Pro Ala Ser Ala Lys Gln His Gly Val Asn 
    930                 935                 940                 


Leu Ser Thr Pro Thr Pro Pro Phe Gln Gln Ala Ser Gly Tyr Gly Gln 
945                 950                 955                 960 


His Gly Tyr Ser Thr Gly Tyr Asp Asp Leu Thr Gln Gly Thr Ala Ala 
                965                 970                 975     


Gly Asp Tyr Ser Lys Gly Gly Tyr Ala Gly Ser Ser Gln Ala Pro Asn 
            980                 985                 990         


Lys Ser Ala Gly Ser Gly Pro Gly  Lys Gly Val Ser Val  Ser Ser Ser 
        995                 1000                 1005             


Thr Thr  Gly Leu Pro Asp Met  Thr Gly Ser Val Tyr  Asn Lys Thr 
    1010                 1015                 1020             


Gln Thr  Phe Asp Lys Gln Gly  Phe His Ala Gly Thr  Pro Pro Pro 
    1025                 1030                 1035             


Phe Ser  Leu Pro Ser Val Leu  Gly Ser Thr Gly Pro  Leu Ala Ser 
    1040                 1045                 1050             


Gly Ala  Ala Pro Gly Tyr Ala  Pro Pro Pro Phe Leu  His Ile Leu 
    1055                 1060                 1065             


Pro Ala  His Gln Gln Pro His  Ser Gln Leu Leu His  His His Leu 
    1070                 1075                 1080             


Pro Gln  Asp Ala Gln Ser Gly  Ser Gly Gln Arg Ser  Gln Pro Ser 
    1085                 1090                 1095             


Ser Leu  Gln Pro Lys Ser Gln  Ala Ser Lys Pro Ala  Tyr Gly Asn 
    1100                 1105                 1110             


Ser Pro  Tyr Trp Thr Asn 
    1115                 


<210>  223
<211>  1721
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
1               5                   10                  15      


Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val 
            20                  25                  30          


His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser Arg 
    50                  55                  60                  


Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val Pro 
65                  70                  75                  80  


Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu Gln 
                85                  90                  95      


Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro Ala 
            100                 105                 110         


Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala Ala 
        115                 120                 125             


Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val Pro 
    130                 135                 140                 


Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln Lys 
145                 150                 155                 160 


Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His Gly 
                165                 170                 175     


Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys Val 
            180                 185                 190         


Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala Gln 
    210                 215                 220                 


Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala Ser 
225                 230                 235                 240 


Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys Lys 
                245                 250                 255     


Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu Thr 
            260                 265                 270         


Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser Gln 
        275                 280                 285             


Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln Thr 
    290                 295                 300                 


Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly Ile 
305                 310                 315                 320 


Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val Gln 
                325                 330                 335     


Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg Ile 
            340                 345                 350         


Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys Gly 
        355                 360                 365             


Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser 
    370                 375                 380                 


Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg Val 
385                 390                 395                 400 


Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg 
                405                 410                 415     


Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile 
            420                 425                 430         


Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln Gln 
        435                 440                 445             


Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr Leu 
    450                 455                 460                 


Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val Gln 
                485                 490                 495     


Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys 
            500                 505                 510         


Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro Val 
        515                 520                 525             


Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val Ile 
    530                 535                 540                 


Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe 
545                 550                 555                 560 


Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser 
                565                 570                 575     


Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe Asn 
            580                 585                 590         


Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln 
        595                 600                 605             


Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys 
    610                 615                 620                 


Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly Glu 
625                 630                 635                 640 


Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe 
                645                 650                 655     


Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile 
            660                 665                 670         


Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln 
        675                 680                 685             


Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys 
    690                 695                 700                 


Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro 
705                 710                 715                 720 


Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr 
                725                 730                 735     


Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly Lys 
            740                 745                 750         


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
        755                 760                 765             


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
    770                 775                 780                 


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
785                 790                 795                 800 


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
                805                 810                 815     


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
            820                 825                 830         


His Leu His Pro Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro Pro 
        835                 840                 845             


Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln 
    850                 855                 860                 


Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn 
865                 870                 875                 880 


Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg Tyr 
                885                 890                 895     


Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys 
            900                 905                 910         


Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser Gln 
        915                 920                 925             


Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala 
    930                 935                 940                 


Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp Glu 
945                 950                 955                 960 


Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr Val 
                965                 970                 975     


Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln 
            980                 985                 990         


Arg Gly Arg Cys Glu Asp Ile Asp  Glu Cys Leu Asn Pro  Ser Thr Cys 
        995                 1000                 1005             


Pro Asp  Glu Gln Cys Val Asn  Ser Pro Gly Ser Tyr  Gln Cys Val 
    1010                 1015                 1020             


Pro Cys  Thr Glu Gly Phe Arg  Gly Trp Asn Gly Gln  Cys Leu Asp 
    1025                 1030                 1035             


Val Asp  Glu Cys Leu Glu Pro  Asn Val Cys Ala Asn  Gly Asp Cys 
    1040                 1045                 1050             


Ser Asn  Leu Glu Gly Ser Tyr  Met Cys Ser Cys His  Lys Gly Tyr 
    1055                 1060                 1065             


Thr Arg  Thr Pro Asp His Lys  His Cys Arg Asp Ile  Asp Glu Cys 
    1070                 1075                 1080             


Gln Gln  Gly Asn Leu Cys Val  Asn Gly Gln Cys Lys  Asn Thr Glu 
    1085                 1090                 1095             


Gly Ser  Phe Arg Cys Thr Cys  Gly Gln Gly Tyr Gln  Leu Ser Ala 
    1100                 1105                 1110             


Ala Lys  Asp Gln Cys Glu Asp  Ile Asp Glu Cys Gln  His Arg His 
    1115                 1120                 1125             


Leu Cys  Ala His Gly Gln Cys  Arg Asn Thr Glu Gly  Ser Phe Gln 
    1130                 1135                 1140             


Cys Val  Cys Asp Gln Gly Tyr  Arg Ala Ser Gly Leu  Gly Asp His 
    1145                 1150                 1155             


Cys Glu  Asp Ile Asn Glu Cys  Leu Glu Asp Lys Ser  Val Cys Gln 
    1160                 1165                 1170             


Arg Gly  Asp Cys Ile Asn Thr  Ala Gly Ser Tyr Asp  Cys Thr Cys 
    1175                 1180                 1185             


Pro Asp  Gly Phe Gln Leu Asp  Asp Asn Lys Thr Cys  Gln Asp Ile 
    1190                 1195                 1200             


Asn Glu  Cys Glu His Pro Gly  Leu Cys Gly Pro Gln  Gly Glu Cys 
    1205                 1210                 1215             


Leu Asn  Thr Glu Gly Ser Phe  His Cys Val Cys Gln  Gln Gly Phe 
    1220                 1225                 1230             


Ser Ile  Ser Ala Asp Gly Arg  Thr Cys Glu Asp Ile  Asp Glu Cys 
    1235                 1240                 1245             


Val Asn  Asn Thr Val Cys Asp  Ser His Gly Phe Cys  Asp Asn Thr 
    1250                 1255                 1260             


Ala Gly  Ser Phe Arg Cys Leu  Cys Tyr Gln Gly Phe  Gln Ala Pro 
    1265                 1270                 1275             


Gln Asp  Gly Gln Gly Cys Val  Asp Val Asn Glu Cys  Glu Leu Leu 
    1280                 1285                 1290             


Ser Gly  Val Cys Gly Glu Ala  Phe Cys Glu Asn Val  Glu Gly Ser 
    1295                 1300                 1305             


Phe Leu  Cys Val Cys Ala Asp  Glu Asn Gln Glu Tyr  Ser Pro Met 
    1310                 1315                 1320             


Thr Gly  Gln Cys Arg Ser Arg  Thr Ser Thr Asp Leu  Asp Val Asp 
    1325                 1330                 1335             


Val Asp  Gln Pro Lys Glu Glu  Lys Lys Glu Cys Tyr  Tyr Asn Leu 
    1340                 1345                 1350             


Asn Asp  Ala Ser Leu Cys Asp  Asn Val Leu Ala Pro  Asn Val Thr 
    1355                 1360                 1365             


Lys Gln  Glu Cys Cys Cys Thr  Ser Gly Val Gly Trp  Gly Asp Asn 
    1370                 1375                 1380             


Cys Glu  Ile Phe Pro Cys Pro  Val Leu Gly Thr Ala  Glu Phe Thr 
    1385                 1390                 1395             


Glu Met  Cys Pro Lys Gly Lys  Gly Phe Val Pro Ala  Gly Glu Ser 
    1400                 1405                 1410             


Ser Ser  Glu Ala Gly Gly Glu  Asn Tyr Lys Asp Ala  Asp Glu Cys 
    1415                 1420                 1425             


Leu Leu  Phe Gly Gln Glu Ile  Cys Lys Asn Gly Phe  Cys Leu Asn 
    1430                 1435                 1440             


Thr Arg  Pro Gly Tyr Glu Cys  Tyr Cys Lys Gln Gly  Thr Tyr Tyr 
    1445                 1450                 1455             


Asp Pro  Val Lys Leu Gln Cys  Phe Asp Met Asp Glu  Cys Gln Asp 
    1460                 1465                 1470             


Pro Ser  Ser Cys Ile Asp Gly  Gln Cys Val Asn Thr  Glu Gly Ser 
    1475                 1480                 1485             


Tyr Asn  Cys Phe Cys Thr His  Pro Met Val Leu Asp  Ala Ser Glu 
    1490                 1495                 1500             


Lys Arg  Cys Ile Arg Pro Ala  Glu Ser Asn Glu Gln  Ile Glu Glu 
    1505                 1510                 1515             


Thr Asp  Val Tyr Gln Asp Leu  Cys Trp Glu His Leu  Ser Asp Glu 
    1520                 1525                 1530             


Tyr Val  Cys Ser Arg Pro Leu  Val Gly Lys Gln Thr  Thr Tyr Thr 
    1535                 1540                 1545             


Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp Gly Met  Gln Cys Ala 
    1550                 1555                 1560             


Leu Cys  Pro Leu Lys Asp Ser  Asp Asp Tyr Ala Gln  Leu Cys Asn 
    1565                 1570                 1575             


Ile Pro  Val Thr Gly Arg Arg  Gln Pro Tyr Gly Arg  Asp Ala Leu 
    1580                 1585                 1590             


Val Asp  Phe Ser Glu Gln Tyr  Thr Pro Glu Ala Asp  Pro Tyr Phe 
    1595                 1600                 1605             


Ile Gln  Asp Arg Phe Leu Asn  Ser Phe Glu Glu Leu  Gln Ala Glu 
    1610                 1615                 1620             


Glu Cys  Gly Ile Leu Asn Gly  Cys Glu Asn Gly Arg  Cys Val Arg 
    1625                 1630                 1635             


Val Gln  Glu Gly Tyr Thr Cys  Asp Cys Phe Asp Gly  Tyr His Leu 
    1640                 1645                 1650             


Asp Thr  Ala Lys Met Thr Cys  Val Asp Val Asn Glu  Cys Asp Glu 
    1655                 1660                 1665             


Leu Asn  Asn Arg Met Ser Leu  Cys Lys Asn Ala Lys  Cys Ile Asn 
    1670                 1675                 1680             


Thr Asp  Gly Ser Tyr Lys Cys  Leu Cys Leu Pro Gly  Tyr Val Pro 
    1685                 1690                 1695             


Ser Asp  Lys Pro Asn Tyr Cys  Thr Pro Leu Asn Thr  Ala Leu Asn 
    1700                 1705                 1710             


Leu Glu  Lys Asp Ser Asp Leu  Glu 
    1715                 1720     


<210>  224
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Asp Val Asp Lys Glu Leu Gly Met Glu Ser Val Lys Ala Gly Ala 
1               5                   10                  15      


Ser Gly Lys Pro Glu Met Arg Leu Gly Thr Gln Glu Glu Thr Ser Glu 
            20                  25                  30          


Gly Asp Ala Asn Glu Ser Ser Leu Leu Val Leu Ser Ser Asn Val Pro 
        35                  40                  45              


Leu Leu Ala Leu Glu Phe Leu Glu Ile Ala Gln Ala Lys Glu Lys Ala 
    50                  55                  60                  


Phe Leu Pro Met Val Ser His Thr Phe His Met Arg Thr Glu Glu Ser 
65                  70                  75                  80  


Asp Ala Ser Gln Glu Gly Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr 
                85                  90                  95      


Ser His Pro Lys Gln Asp Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile 
            100                 105                 110         


Gln Pro Lys Glu Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln 
        115                 120                 125             


Ser Lys Lys Glu Asp Leu Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro 
    130                 135                 140                 


Lys Glu Ser Asn Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys 
145                 150                 155                 160 


Leu Gly Asn Ile Pro Lys Ala Ser Val Lys Pro Ser Gln Pro Lys Glu 
                165                 170                 175     


Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu 
            180                 185                 190         


Asp Leu Pro Lys Ser Ser Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp 
        195                 200                 205             


Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile 
    210                 215                 220                 


Ala Lys Thr Ser Val Lys Pro Ser Gln Pro Lys Glu Ser Asp Ile Pro 
225                 230                 235                 240 


Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys 
                245                 250                 255     


Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Pro Lys Ala 
            260                 265                 270         


Ser Val Lys Pro Ser Gln Pro Lys Glu Gly Asp Ile Ser Lys Ser Pro 
        275                 280                 285             


Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Leu Pro Lys Ser Leu Glu 
    290                 295                 300                 


Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu 
305                 310                 315                 320 


Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala 
                325                 330                 335     


Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile 
            340                 345                 350         


Gln Pro Lys Lys Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln 
        355                 360                 365             


Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Lys Gln Ala Ile Gln Pro 
    370                 375                 380                 


Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Pro Pro Lys 
385                 390                 395                 400 


Glu Ile Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu 
                405                 410                 415     


Asp Asp Ser Pro Lys Ser Leu Glu Glu Ala Thr Pro Ser Lys Glu Gly 
            420                 425                 430         


Asp Ile Leu Lys Pro Glu Glu Glu Thr Met Glu Phe Pro Glu Gly Asp 
        435                 440                 445             


Lys Val Lys Val Ile Leu Ser Lys Glu Asp Phe Glu Ala Ser Leu Lys 
    450                 455                 460                 


Glu Ala Gly Glu Arg Leu Val Ala Val Asp Phe Ser Ala Thr Trp Cys 
465                 470                 475                 480 


Gly Pro Cys Arg Thr Ile Arg Pro Phe Phe His Ala Leu Ser Val Lys 
                485                 490                 495     


His Glu Asp Val Val Phe Leu Glu Val Asp Ala Asp Asn Cys Glu Glu 
            500                 505                 510         


Val Val Arg Glu Cys Ala Ile Met Cys Val Pro Thr Phe Gln Phe Tyr 
        515                 520                 525             


Lys Lys Glu Glu Lys Val Asp Glu Leu Cys Gly Ala Leu Lys Glu Lys 
    530                 535                 540                 


Leu Glu Ala Val Ile Ala Glu Leu Lys 
545                 550             


<210>  225
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Arg Val Val Thr Ile Val Ile Leu Leu Cys Phe Cys Lys Ala Ala 
1               5                   10                  15      


Glu Leu Arg Lys Ala Ser Pro Gly Ser Val Arg Ser Arg Val Asn His 
            20                  25                  30          


Gly Arg Ala Gly Gly Gly Arg Arg Gly Ser Asn Pro Val Lys Arg Tyr 
        35                  40                  45              


Ala Pro Gly Leu Pro Cys Asp Val Tyr Thr Tyr Leu His Glu Lys Tyr 
    50                  55                  60                  


Leu Asp Cys Gln Glu Arg Lys Leu Val Tyr Val Leu Pro Gly Trp Pro 
65                  70                  75                  80  


Gln Asp Leu Leu His Met Leu Leu Ala Arg Asn Lys Ile Arg Thr Leu 
                85                  90                  95      


Lys Asn Asn Met Phe Ser Lys Phe Lys Lys Leu Lys Ser Leu Asp Leu 
            100                 105                 110         


Gln Gln Asn Glu Ile Ser Lys Ile Glu Ser Glu Ala Phe Phe Gly Leu 
        115                 120                 125             


Asn Lys Leu Thr Thr Leu Leu Leu Gln His Asn Gln Ile Lys Val Leu 
    130                 135                 140                 


Thr Glu Glu Val Phe Ile Tyr Thr Pro Leu Leu Ser Tyr Leu Arg Leu 
145                 150                 155                 160 


Tyr Asp Asn Pro Trp His Cys Thr Cys Glu Ile Glu Thr Leu Ile Ser 
                165                 170                 175     


Met Leu Gln Ile Pro Arg Asn Arg Asn Leu Gly Asn Tyr Ala Lys Cys 
            180                 185                 190         


Glu Ser Pro Gln Glu Gln Lys Asn Lys Lys Leu Arg Gln Ile Lys Ser 
        195                 200                 205             


Glu Gln Leu Cys Asn Glu Glu Glu Lys Glu Gln Leu Asp Pro Lys Pro 
    210                 215                 220                 


Gln Val Ser Gly Arg Pro Pro Val Ile Lys Pro Glu Val Asp Ser Thr 
225                 230                 235                 240 


Phe Cys His Asn Tyr Val Phe Pro Ile Gln Thr Leu Asp Cys Lys Arg 
                245                 250                 255     


Lys Glu Leu Lys Lys Val Pro Asn Asn Ile Pro Pro Asp Ile Val Lys 
            260                 265                 270         


Leu Asp Leu Ser Tyr Asn Lys Ile Asn Gln Leu Arg Pro Lys Glu Phe 
        275                 280                 285             


Glu Asp Val His Glu Leu Lys Lys Leu Asn Leu Ser Ser Asn Gly Ile 
    290                 295                 300                 


Glu Phe Ile Asp Pro Ala Ala Phe Leu Gly Leu Thr His Leu Glu Glu 
305                 310                 315                 320 


Leu Asp Leu Ser Asn Asn Ser Leu Gln Asn Phe Asp Tyr Gly Val Leu 
                325                 330                 335     


Glu Asp Leu Tyr Phe Leu Lys Leu Leu Trp Leu Arg Asp Asn Pro Trp 
            340                 345                 350         


Arg Cys Asp Tyr Asn Ile His Tyr Leu Tyr Tyr Trp Leu Lys His His 
        355                 360                 365             


Tyr Asn Val His Phe Asn Gly Leu Glu Cys Lys Thr Pro Glu Glu Tyr 
    370                 375                 380                 


Lys Gly Trp Ser Val Gly Lys Tyr Ile Arg Ser Tyr Tyr Glu Glu Cys 
385                 390                 395                 400 


Pro Lys Asp Lys Leu Pro Ala Tyr Pro Glu Ser Phe Asp Gln Asp Thr 
                405                 410                 415     


Glu Asp Asp Glu Trp Glu Lys Lys His Arg Asp His Thr Ala Lys Lys 
            420                 425                 430         


Gln Ser Val Ile Ile Thr Ile Val Gly 
        435                 440     


<210>  226
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ser Arg Gly Thr Met Pro Gln Pro Glu Ala Trp Pro Gly Ala Ser 
1               5                   10                  15      


Cys Ala Glu Thr Pro Ala Arg Glu Ala Ala Ala Thr Ala Arg Asp Gly 
            20                  25                  30          


Gly Lys Ala Ala Ala Ser Gly Gln Pro Arg Pro Glu Met Gln Cys Pro 
        35                  40                  45              


Ala Glu His Glu Glu Asp Met Tyr Arg Ala Ala Asp Glu Ile Glu Lys 
    50                  55                  60                  


Glu Lys Glu Leu Leu Ile His Glu Arg Gly Ala Ser Glu Pro Arg Leu 
65                  70                  75                  80  


Ser Val Ala Pro Glu Met Asp Ile Met Asp Tyr Cys Lys Lys Glu Trp 
                85                  90                  95      


Arg Gly Asn Thr Gln Lys Ala Thr Cys Met Lys Met Gly Tyr Glu Glu 
            100                 105                 110         


Val Ser Gln Lys Phe Thr Ser Ile Arg Arg Val Arg Gly Asp Asn Tyr 
        115                 120                 125             


Cys Ala Leu Arg Ala Thr Leu Phe Gln Ala Met Ser Gln Ala Val Gly 
    130                 135                 140                 


Leu Pro Pro Trp Leu Gln Asp Pro Glu Leu Met Leu Leu Pro Glu Lys 
145                 150                 155                 160 


Leu Ile Ser Lys Tyr Asn Trp Ile Lys Gln Trp Lys Leu Gly Leu Lys 
                165                 170                 175     


Phe Asp Gly Lys Asn Glu Asp Leu Val Asp Lys Ile Lys Glu Ser Leu 
            180                 185                 190         


Thr Leu Leu Arg Lys Lys Trp Ala Gly Leu Ala Glu Met Arg Thr Ala 
        195                 200                 205             


Glu Ala Arg Gln Ile Ala Cys Asp Glu Leu Phe Thr Asn Glu Ala Glu 
    210                 215                 220                 


Glu Tyr Ser Leu Tyr Glu Ala Val Lys Phe Leu Met Leu Asn Arg Ala 
225                 230                 235                 240 


Ile Glu Leu Tyr Asn Asp Lys Glu Lys Gly Lys Glu Val Pro Phe Phe 
                245                 250                 255     


Ser Val Leu Leu Phe Ala Arg Asp Thr Ser Asn Asp Pro Gly Gln Leu 
            260                 265                 270         


Leu Arg Asn His Leu Asn Gln Val Gly His Thr Gly Gly Leu Glu Gln 
        275                 280                 285             


Val Glu Met Phe Leu Leu Ala Tyr Ala Val Arg His Thr Ile Gln Val 
    290                 295                 300                 


Tyr Arg Leu Ser Lys Tyr Asn Thr Glu Glu Phe Ile Thr Val Tyr Pro 
305                 310                 315                 320 


Thr Asp Pro Pro Lys Asp Trp Pro Val Val Thr Leu Ile Ala Glu Asp 
                325                 330                 335     


Asp Arg His Tyr Asn Ile Pro Val Arg Val Cys Glu Glu Thr Ser Leu 
            340                 345                 350         


<210>  227
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Pro Leu Leu Glu Gly Ser Val Gly Val Glu Asp Leu Val Leu Leu 
1               5                   10                  15      


Glu Pro Leu Val Glu Glu Ser Leu Leu Lys Asn Leu Gln Leu Arg Tyr 
            20                  25                  30          


Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly Asn Val Val Ile Ser Val 
        35                  40                  45              


Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly Pro Glu Phe Ile Ala Lys 
    50                  55                  60                  


Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys Pro His Ile Tyr Ala Leu 
65                  70                  75                  80  


Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp Arg Asp Arg Asp Gln Cys 
                85                  90                  95      


Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Ser Lys 
            100                 105                 110         


Leu Val Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly Glu Gln Val 
        115                 120                 125             


Asn Ser Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala 
    130                 135                 140                 


Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn Asn Ser Ser Arg Phe Gly 
145                 150                 155                 160 


Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys Gly Ser Pro Leu Gly Gly 
                165                 170                 175     


Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser Arg Leu Val Lys Gln Leu 
            180                 185                 190         


Lys Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu Leu Ala Gly Ala 
        195                 200                 205             


Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu Glu Arg Asp Thr Thr Gly 
    210                 215                 220                 


Tyr Ala Tyr Leu Asn His Glu Val Ser Arg Val Asp Gly Met Asp Asp 
225                 230                 235                 240 


Ala Ser Ser Phe Arg Ala Val Gln Ser Ala Met Ala Val Ile Gly Phe 
                245                 250                 255     


Ser Glu Glu Glu Ile Arg Gln Val Leu Glu Val Thr Ser Met Val Leu 
            260                 265                 270         


Lys Leu Gly Asn Val Leu Val Ala Asp Glu Phe Gln Ala Ser Gly Ile 
        275                 280                 285             


Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly Val Arg Glu Ile Gly Glu 
    290                 295                 300                 


Met Val Gly Leu Asn Ser Glu Glu Val Glu Arg Ala Leu Cys Ser Arg 
305                 310                 315                 320 


Thr Met Glu Thr Ala Lys Glu Lys Val Val Thr Ala Leu Asn Val Met 
                325                 330                 335     


Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala Lys Asn Ile Tyr Ser Arg 
            340                 345                 350         


Leu Phe Asp Trp Ile Val Asn Arg Ile Asn Glu Ser Ile Lys Val Gly 
        355                 360                 365             


Ile Gly Glu Lys Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe 
    370                 375                 380                 


Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln Phe Val Ile Asn Tyr Cys 
385                 390                 395                 400 


Asn Glu Lys Leu Gln Gln Val Phe Ile Glu Met Thr Leu Lys Glu Glu 
                405                 410                 415     


Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro Trp Thr Lys Val Asp Tyr 
            420                 425                 430         


Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile Glu His Asn Gln Arg Gly 
        435                 440                 445             


Ile Leu Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Val Val Ser 
    450                 455                 460                 


Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln Leu Phe Ser Lys His Gly 
465                 470                 475                 480 


His Tyr Glu Ser Lys Val Thr Gln Asn Ala Gln Arg Gln Tyr Asp His 
                485                 490                 495     


Thr Met Gly Leu Ser Cys Phe Arg Ile Cys His Tyr Ala Gly Lys Val 
            500                 505                 510         


Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys Asn Asn Asp Leu Leu Phe 
        515                 520                 525             


Arg Asp Leu Leu Gln Ala Met Trp Lys Ala Gln His Pro Leu Leu Arg 
    530                 535                 540                 


Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln Ala Ser Leu Lys Arg Pro 
545                 550                 555                 560 


Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser Val Ala Ile Leu Met Lys 
                565                 570                 575     


Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn 
            580                 585                 590         


Glu His Gln Gln Arg Gly Gln Phe Ser Ser Asp Leu Val Ala Thr Gln 
        595                 600                 605             


Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly 
    610                 615                 620                 


Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe Leu Glu Arg Tyr Arg Leu 
625                 630                 635                 640 


Leu Ser Arg Ser Thr Trp Pro His Trp Asn Gly Gly Asp Arg Glu Gly 
                645                 650                 655     


Val Glu Lys Val Leu Gly Glu Leu Ser Met Ser Ser Gly Glu Leu Ala 
            660                 665                 670         


Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser Pro Lys Thr Leu Phe Tyr 
        675                 680                 685             


Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln Gln Leu Ala Thr Leu Ile 
    690                 695                 700                 


Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg Thr His Tyr Gln Leu Met 
705                 710                 715                 720 


Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp Phe Arg Gly Asn Met Gln 
                725                 730                 735     


Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser Val Leu Leu Ile Gln Ala 
            740                 745                 750         


Phe Val Arg Gly Trp Lys Ala Arg Lys Asn Tyr Arg Lys Tyr Phe Arg 
        755                 760                 765             


Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe Ile Tyr Lys Ser Met Val 
    770                 775                 780                 


Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn Leu Pro Ser Thr Asn Val 
785                 790                 795                 800 


Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr Lys Cys Leu Ser Thr Ala 
                805                 810                 815     


Asn Gln Glu Leu Gln Gln Leu Phe Tyr Gln Trp Lys Cys Lys Arg Phe 
            820                 825                 830         


Arg Asp Gln Leu Ser Pro Lys Gln Val Glu Ile Leu Arg Glu Lys Leu 
        835                 840                 845             


Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys Ala Ser Tyr Pro Gln Ser 
    850                 855                 860                 


Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile Gly Leu Gln Gly Asn Pro 
865                 870                 875                 880 


Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu Gly Pro Val Leu Met Ala 
                885                 890                 895     


Glu Ala Val Lys Lys Val Asn Arg Gly Asn Gly Lys Thr Ser Ser Arg 
            900                 905                 910         


Ile Leu Leu Leu Thr Lys Gly His Val Ile Leu Thr Asp Thr Lys Lys 
        915                 920                 925             


Ser Gln Ala Lys Ile Val Ile Gly Leu Asp Asn Val Ala Gly Val Ser 
    930                 935                 940                 


Val Thr Ser Leu Lys Asp Gly Leu Phe Ser Leu His Leu Ser Glu Met 
945                 950                 955                 960 


Ser Ser Val Gly Ser Lys Gly Asp Phe Leu Leu Val Ser Glu His Val 
                965                 970                 975     


Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala Val Leu Asp Ala Thr Gln 
            980                 985                 990         


Arg Gln Leu Thr Val Thr Val Thr  Glu Lys Phe Ser Val  Arg Phe Lys 
        995                 1000                 1005             


Glu Asn  Ser Val Ala Val Lys  Val Val Gln Gly Pro  Ala Gly Gly 
    1010                 1015                 1020             


Asp Asn  Ser Lys Leu Arg Tyr  Lys Lys Lys Gly Ser  His Cys Leu 
    1025                 1030                 1035             


Glu Val  Thr Val Gln 
    1040             


<210>  228
<211>  1575
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Pro His Glu Glu Leu Pro Ser Leu Gln Arg Pro Arg Tyr Gly Ser 
1               5                   10                  15      


Ile Val Asp Asp Glu Arg Leu Ser Ala Glu Glu Met Asp Glu Arg Arg 
            20                  25                  30          


Arg Gln Asn Ile Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys 
        35                  40                  45              


Arg Trp Met Glu Val Cys Leu Val Glu Glu Leu Pro Pro Thr Thr Glu 
    50                  55                  60                  


Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Ala Lys 
65                  70                  75                  80  


Phe Phe Ala Pro Lys Met Val Ser Glu Lys Lys Ile Tyr Asp Val Glu 
                85                  90                  95      


Gln Thr Arg Tyr Lys Lys Ser Gly Leu His Phe Arg His Thr Asp Asn 
            100                 105                 110         


Thr Val Gln Trp Leu Arg Ala Met Glu Ser Ile Gly Leu Pro Lys Ile 
        115                 120                 125             


Phe Tyr Pro Glu Thr Thr Asp Val Tyr Asp Arg Lys Asn Ile Pro Arg 
    130                 135                 140                 


Met Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly 
145                 150                 155                 160 


Ile Ala Pro Gln Ile Gln Asp Leu Leu Gly Lys Val Asp Phe Thr Glu 
                165                 170                 175     


Glu Glu Ile Ser Asn Met Arg Lys Glu Leu Glu Lys Tyr Gly Ile Gln 
            180                 185                 190         


Met Pro Ser Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser 
        195                 200                 205             


Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala 
    210                 215                 220                 


Val Glu Lys Gly Ile Ala Glu Gln Thr Val Val Thr Leu Arg Asn Pro 
225                 230                 235                 240 


Asn Ala Val Leu Thr Leu Val Asp Asp Asn Leu Ala Pro Glu Tyr Gln 
                245                 250                 255     


Lys Glu Leu Trp Asp Ala Lys Lys Lys Lys Glu Glu Asn Ala Arg Leu 
            260                 265                 270         


Lys Asn Ser Cys Ile Ser Glu Glu Glu Arg Asp Ala Tyr Glu Glu Leu 
        275                 280                 285             


Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Arg Gln 
    290                 295                 300                 


Ala Ala Val Asp His Ile Asn Ala Val Ile Pro Glu Gly Asp Pro Glu 
305                 310                 315                 320 


Asn Thr Leu Leu Ala Leu Lys Lys Pro Glu Ala Gln Leu Pro Ala Val 
                325                 330                 335     


Tyr Pro Phe Ala Ala Ala Met Tyr Gln Asn Glu Leu Phe Asn Leu Gln 
            340                 345                 350         


Lys Gln Asn Thr Met Asn Tyr Leu Ala His Glu Glu Leu Leu Ile Ala 
        355                 360                 365             


Val Glu Met Leu Ser Ala Val Ala Leu Leu Asn Gln Ala Leu Glu Ser 
    370                 375                 380                 


Asn Asp Leu Val Ser Val Gln Asn Gln Leu Arg Ser Pro Ala Ile Gly 
385                 390                 395                 400 


Leu Asn Asn Leu Asp Lys Ala Tyr Val Glu Arg Tyr Ala Asn Thr Leu 
                405                 410                 415     


Leu Ser Val Lys Leu Glu Val Leu Ser Gln Gly Gln Asp Asn Leu Ser 
            420                 425                 430         


Trp Asn Glu Ile Gln Asn Cys Ile Asp Met Val Asn Ala Gln Ile Gln 
        435                 440                 445             


Glu Glu Asn Asp Arg Val Val Ala Val Gly Tyr Ile Asn Glu Ala Ile 
    450                 455                 460                 


Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro Thr 
465                 470                 475                 480 


Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln Asp 
                485                 490                 495     


Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser Val 
            500                 505                 510         


Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Asp Ala 
        515                 520                 525             


Asn Val Asp Lys Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val Asp 
    530                 535                 540                 


Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser Val 
545                 550                 555                 560 


Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys Ala 
                565                 570                 575     


Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser Glu 
            580                 585                 590         


Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys Lys 
        595                 600                 605             


Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val Thr 
    610                 615                 620                 


Pro Glu Ser Cys Leu Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu Ile 
625                 630                 635                 640 


Glu Asp Ile Ile Glu Glu Val Thr Val Gly Tyr Ile Arg Glu Asn Ile 
                645                 650                 655     


Trp Ser Ala Ser Glu Glu Leu Leu Leu Arg Phe Gln Ala Thr Ser Ser 
            660                 665                 670         


Gly Pro Ile Leu Arg Glu Glu Phe Glu Ala Arg Lys Ser Phe Leu His 
        675                 680                 685             


Glu Gln Glu Glu Asn Val Val Lys Ile Gln Ala Phe Trp Lys Gly Tyr 
    690                 695                 700                 


Lys Gln Arg Lys Glu Tyr Met His Arg Arg Gln Thr Phe Ile Asp Asn 
705                 710                 715                 720 


Thr Asp Ser Ile Val Lys Ile Gln Ser Trp Phe Arg Met Ala Thr Ala 
                725                 730                 735     


Arg Lys Ser Tyr Leu Ser Arg Leu Gln Tyr Phe Arg Asp His Asn Asn 
            740                 745                 750         


Glu Ile Val Lys Ile Gln Ser Leu Leu Arg Ala Asn Lys Ala Arg Asp 
        755                 760                 765             


Asp Tyr Lys Thr Leu Val Gly Ser Glu Asn Pro Pro Leu Thr Val Ile 
    770                 775                 780                 


Arg Lys Phe Val Tyr Leu Leu Asp Gln Ser Asp Leu Asp Phe Gln Glu 
785                 790                 795                 800 


Glu Leu Glu Val Ala Arg Leu Arg Glu Glu Val Val Thr Lys Ile Arg 
                805                 810                 815     


Ala Asn Gln Gln Leu Glu Lys Asp Leu Asn Leu Met Asp Ile Lys Ile 
            820                 825                 830         


Gly Leu Leu Val Lys Asn Arg Ile Thr Leu Glu Asp Val Ile Ser His 
        835                 840                 845             


Ser Lys Lys Leu Asn Lys Lys Lys Gly Gly Glu Met Glu Ile Leu Asn 
    850                 855                 860                 


Asn Thr Asp Asn Gln Gly Ile Lys Ser Leu Ser Lys Glu Arg Arg Lys 
865                 870                 875                 880 


Thr Leu Glu Thr Tyr Gln Gln Leu Phe Tyr Leu Leu Gln Thr Asn Pro 
                885                 890                 895     


Leu Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys Ser Thr 
            900                 905                 910         


Lys Phe Met Asp Thr Val Ile Phe Thr Leu Tyr Asn Tyr Ala Ser Asn 
        915                 920                 925             


Gln Arg Glu Glu Tyr Leu Leu Leu Lys Leu Phe Lys Thr Ala Leu Glu 
    930                 935                 940                 


Glu Glu Ile Lys Ser Lys Val Asp Gln Val Gln Asp Ile Val Thr Gly 
945                 950                 955                 960 


Asn Pro Thr Val Ile Lys Met Val Val Ser Phe Asn Arg Gly Ala Arg 
                965                 970                 975     


Gly Gln Asn Thr Leu Arg Gln Leu Leu Ala Pro Val Val Lys Glu Ile 
            980                 985                 990         


Ile Asp Asp Lys Ser Leu Ile Ile  Asn Thr Asn Pro Val  Glu Val Tyr 
        995                 1000                 1005             


Lys Ala  Trp Val Asn Gln Leu  Glu Thr Gln Thr Gly  Glu Ala Ser 
    1010                 1015                 1020             


Lys Leu  Pro Tyr Asp Val Thr  Thr Glu Gln Ala Leu  Thr Tyr Pro 
    1025                 1030                 1035             


Glu Val  Lys Asn Lys Leu Glu  Ala Ser Ile Glu Asn  Leu Arg Arg 
    1040                 1045                 1050             


Val Thr  Asp Lys Val Leu Asn  Ser Ile Ile Ser Ser  Leu Asp Leu 
    1055                 1060                 1065             


Leu Pro  Tyr Gly Leu Arg Tyr  Ile Ala Lys Val Leu  Lys Asn Ser 
    1070                 1075                 1080             


Ile His  Glu Lys Phe Pro Asp  Ala Thr Glu Asp Glu  Leu Leu Lys 
    1085                 1090                 1095             


Ile Val  Gly Asn Leu Leu Tyr  Tyr Arg Tyr Met Asn  Pro Ala Ile 
    1100                 1105                 1110             


Val Ala  Pro Asp Gly Phe Asp  Ile Ile Asp Met Thr  Ala Gly Gly 
    1115                 1120                 1125             


Gln Ile  Asn Ser Asp Gln Arg  Arg Asn Leu Gly Ser  Val Ala Lys 
    1130                 1135                 1140             


Val Leu  Gln His Ala Ala Ser  Asn Lys Leu Phe Glu  Gly Glu Asn 
    1145                 1150                 1155             


Glu His  Leu Ser Ser Met Asn  Asn Tyr Leu Ser Glu  Thr Tyr Gln 
    1160                 1165                 1170             


Glu Phe  Arg Lys Tyr Phe Lys  Glu Ala Cys Asn Val  Pro Glu Pro 
    1175                 1180                 1185             


Glu Glu  Lys Phe Asn Met Asp  Lys Tyr Thr Asp Leu  Val Thr Val 
    1190                 1195                 1200             


Ser Lys  Pro Val Ile Tyr Ile  Ser Ile Glu Glu Ile  Ile Ser Thr 
    1205                 1210                 1215             


His Ser  Leu Leu Leu Glu His  Gln Asp Ala Ile Ala  Pro Glu Lys 
    1220                 1225                 1230             


Asn Asp  Leu Leu Ser Glu Leu  Leu Gly Ser Leu Gly  Glu Val Pro 
    1235                 1240                 1245             


Thr Val  Glu Ser Phe Leu Gly  Glu Gly Ala Val Asp  Pro Asn Asp 
    1250                 1255                 1260             


Pro Asn  Lys Ala Asn Thr Leu  Ser Gln Leu Ser Lys  Thr Glu Ile 
    1265                 1270                 1275             


Ser Leu  Val Leu Thr Ser Lys  Tyr Asp Ile Glu Asp  Gly Glu Ala 
    1280                 1285                 1290             


Ile Asp  Ser Arg Ser Leu Met  Ile Lys Thr Lys Lys  Leu Ile Ile 
    1295                 1300                 1305             


Asp Val  Ile Arg Asn Gln Pro  Gly Asn Thr Leu Thr  Glu Ile Leu 
    1310                 1315                 1320             


Glu Thr  Pro Ala Thr Ala Gln  Gln Glu Val Asp His  Ala Thr Asp 
    1325                 1330                 1335             


Met Val  Ser Arg Ala Met Ile  Asp Ser Arg Thr Pro  Glu Glu Met 
    1340                 1345                 1350             


Lys His  Ser Gln Ser Met Ile  Glu Asp Ala Gln Leu  Pro Leu Glu 
    1355                 1360                 1365             


Gln Lys  Lys Arg Lys Ile Gln  Arg Asn Leu Arg Thr  Leu Glu Gln 
    1370                 1375                 1380             


Thr Gly  His Val Ser Ser Glu  Asn Lys Tyr Gln Asp  Ile Leu Asn 
    1385                 1390                 1395             


Glu Ile  Ala Lys Asp Ile Arg  Asn Gln Arg Ile Tyr  Arg Lys Leu 
    1400                 1405                 1410             


Arg Lys  Ala Glu Leu Ala Lys  Leu Gln Gln Thr Leu  Asn Ala Leu 
    1415                 1420                 1425             


Asn Lys  Lys Ala Ala Phe Tyr  Glu Glu Gln Ile Asn  Tyr Tyr Asp 
    1430                 1435                 1440             


Thr Tyr  Ile Lys Thr Cys Leu  Asp Asn Leu Lys Arg  Lys Asn Thr 
    1445                 1450                 1455             


Arg Arg  Ser Ile Lys Leu Asp  Gly Lys Gly Glu Pro  Lys Gly Ala 
    1460                 1465                 1470             


Lys Arg  Ala Lys Pro Val Lys  Tyr Thr Ala Ala Lys  Leu His Glu 
    1475                 1480                 1485             


Lys Gly  Val Leu Leu Asp Ile  Asp Asp Leu Gln Thr  Asn Gln Phe 
    1490                 1495                 1500             


Lys Asn  Val Thr Phe Asp Ile  Ile Ala Thr Glu Asp  Val Gly Ile 
    1505                 1510                 1515             


Phe Asp  Val Arg Ser Lys Phe  Leu Gly Val Glu Met  Glu Lys Val 
    1520                 1525                 1530             


Gln Leu  Asn Ile Gln Asp Leu  Leu Gln Met Gln Tyr  Glu Gly Val 
    1535                 1540                 1545             


Ala Val  Met Lys Met Phe Asp  Lys Val Lys Val Asn  Val Asn Leu 
    1550                 1555                 1560             


Leu Ile  Tyr Leu Leu Asn Lys  Lys Phe Tyr Gly Lys  
    1565                 1570                 1575 


<210>  229
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Ile Thr Ser Ala Ala Gly Ile Ile Ser Leu Leu Asp Glu Asp Glu 
1               5                   10                  15      


Pro Gln Leu Lys Glu Phe Ala Leu His Lys Leu Asn Ala Val Val Asn 
            20                  25                  30          


Asp Phe Trp Ala Glu Ile Ser Glu Ser Val Asp Lys Ile Glu Val Leu 
        35                  40                  45              


Tyr Glu Asp Glu Gly Phe Arg Ser Arg Gln Phe Ala Ala Leu Val Ala 
    50                  55                  60                  


Ser Lys Val Phe Tyr His Leu Gly Ala Phe Glu Glu Ser Leu Asn Tyr 
65                  70                  75                  80  


Ala Leu Gly Ala Gly Asp Leu Phe Asn Val Asn Asp Asn Ser Glu Tyr 
                85                  90                  95      


Val Glu Thr Ile Ile Ala Lys Cys Ile Asp His Tyr Thr Lys Gln Cys 
            100                 105                 110         


Val Glu Asn Ala Asp Leu Pro Glu Gly Glu Lys Lys Pro Ile Asp Gln 
        115                 120                 125             


Arg Leu Glu Gly Ile Val Asn Lys Met Phe Gln Arg Cys Leu Asp Asp 
    130                 135                 140                 


His Lys Tyr Lys Gln Ala Ile Gly Ile Ala Leu Glu Thr Arg Arg Leu 
145                 150                 155                 160 


Asp Val Phe Glu Lys Thr Ile Leu Glu Ser Asn Asp Val Pro Gly Met 
                165                 170                 175     


Leu Ala Tyr Ser Leu Lys Leu Cys Met Ser Leu Met Gln Asn Lys Gln 
            180                 185                 190         


Phe Arg Asn Lys Val Leu Arg Val Leu Val Lys Ile Tyr Met Asn Leu 
        195                 200                 205             


Glu Lys Pro Asp Phe Ile Asn Val Cys Gln Cys Leu Ile Phe Leu Asp 
    210                 215                 220                 


Asp Pro Gln Ala Val Ser Asp Ile Leu Glu Lys Leu Val Lys Glu Asp 
225                 230                 235                 240 


Asn Leu Leu Met Ala Tyr Gln Ile Cys Phe Asp Leu Tyr Glu Ser Ala 
                245                 250                 255     


Ser Gln Gln Phe Leu Ser Ser Val Ile Gln Asn Leu Arg Thr Val Gly 
            260                 265                 270         


Thr Pro Ile Ala Ser Val Pro Gly Ser Thr Asn Thr Gly Thr Val Pro 
        275                 280                 285             


Gly Ser Glu Lys Asp Ser Asp Ser Met Glu Thr Glu Glu Lys Thr Ser 
    290                 295                 300                 


Ser Ala Phe Val Gly Lys Thr Pro Glu Ala Ser Pro Glu Pro Lys Asp 
305                 310                 315                 320 


Gln Thr Leu Lys Met Ile Lys Ile Leu Ser Gly Glu Met Ala Ile Glu 
                325                 330                 335     


Leu His Leu Gln Phe Leu Ile Arg Asn Asn Asn Thr Asp Leu Met Ile 
            340                 345                 350         


Leu Lys Asn Thr Lys Asp Ala Val Arg Asn Ser Val Cys His Thr Ala 
        355                 360                 365             


Thr Val Ile Ala Asn Ser Phe Met His Cys Gly Thr Thr Ser Asp Gln 
    370                 375                 380                 


Phe Leu Arg Asp Asn Leu Glu Trp Leu Ala Arg Ala Thr Asn Trp Ala 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Ala Ser Leu Gly Val Ile His Lys Gly His Glu 
                405                 410                 415     


Lys Glu Ala Leu Gln Leu Met Ala Thr Tyr Leu Pro Lys Asp Thr Ser 
            420                 425                 430         


Pro Gly Ser Ala Tyr Gln Glu Gly Gly Gly Leu Tyr Ala Leu Gly Leu 
        435                 440                 445             


Ile His Ala Asn His Gly Gly Asp Ile Ile Asp Tyr Leu Leu Asn Gln 
    450                 455                 460                 


Leu Lys Asn Ala Ser Asn Asp Ile Val Arg His Gly Gly Ser Leu Gly 
465                 470                 475                 480 


Leu Gly Leu Ala Ala Met Gly Thr Ala Arg Gln Asp Val Tyr Asp Leu 
                485                 490                 495     


Leu Lys Thr Asn Leu Tyr Gln Asp Asp Ala Val Thr Gly Glu Ala Ala 
            500                 505                 510         


Gly Leu Ala Leu Gly Leu Val Met Leu Gly Ser Lys Asn Ala Gln Ala 
        515                 520                 525             


Ile Glu Asp Met Val Gly Tyr Ala Gln Glu Thr Gln His Glu Lys Ile 
    530                 535                 540                 


Leu Arg Gly Leu Ala Val Gly Ile Ala Leu Val Met Tyr Gly Arg Met 
545                 550                 555                 560 


Glu Glu Ala Asp Ala Leu Ile Glu Ser Leu Cys Arg Asp Lys Asp Pro 
                565                 570                 575     


Ile Leu Arg Arg Ser Gly Met Tyr Thr Val Ala Met Ala Tyr Cys Gly 
            580                 585                 590         


Ser Gly Asn Asn Lys Ala Ile Arg Arg Leu Leu His Val Ala Val Ser 
        595                 600                 605             


Asp Val Asn Asp Asp Val Arg Arg Ala Ala Val Glu Ser Leu Gly Phe 
    610                 615                 620                 


Ile Leu Phe Arg Thr Pro Glu Gln Cys Pro Ser Val Val Ser Leu Leu 
625                 630                 635                 640 


Ser Glu Ser Tyr Asn Pro His Val Arg Tyr Gly Ala Ala Met Ala Leu 
                645                 650                 655     


Gly Ile Cys Cys Ala Gly Thr Gly Asn Lys Glu Ala Ile Asn Leu Leu 
            660                 665                 670         


Glu Pro Met Thr Asn Asp Pro Val Asn Tyr Val Arg Gln Gly Ala Leu 
        675                 680                 685             


Ile Ala Ser Ala Leu Ile Met Ile Gln Gln Thr Glu Ile Thr Cys Pro 
    690                 695                 700                 


Lys Val Asn Gln Phe Arg Gln Leu Tyr Ser Lys Val Ile Asn Asp Lys 
705                 710                 715                 720 


His Asp Asp Val Met Ala Lys Phe Gly Ala Ile Leu Ala Gln Gly Ile 
                725                 730                 735     


Leu Asp Ala Gly Gly His Asn Val Thr Ile Ser Leu Gln Ser Arg Thr 
            740                 745                 750         


Gly His Thr His Met Pro Ser Val Val Gly Val Leu Val Phe Thr Gln 
        755                 760                 765             


Phe Trp Phe Trp Phe Pro Leu Ser His Phe Leu Ser Leu Ala Tyr Thr 
    770                 775                 780                 


Pro Thr Cys Val Ile Gly Leu Asn Lys Asp Leu Lys Met Pro Lys Val 
785                 790                 795                 800 


Gln Tyr Lys Ser Asn Cys Lys Pro Ser Thr Phe Ala Tyr Pro Ala Pro 
                805                 810                 815     


Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val 
            820                 825                 830         


Leu Ser Ile Thr Ala Lys Ala Lys Lys Lys Glu Lys Glu Lys Glu Lys 
        835                 840                 845             


Lys Glu Glu Glu Lys Met Glu Val Asp Glu Ala Glu Lys Lys Glu Glu 
    850                 855                 860                 


Lys Glu Lys Lys Lys Glu Pro Glu Pro Asn Phe Gln Leu Leu Asp Asn 
865                 870                 875                 880 


Pro Ala Arg Val Met Pro Ala Gln Leu Lys Val Leu Thr Met Pro Glu 
                885                 890                 895     


Thr Cys Arg Tyr Gln Pro Phe Lys Pro Leu Ser Ile Gly Gly Ile Ile 
            900                 905                 910         


Ile Leu Lys Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val 
        915                 920                 925             


Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro 
    930                 935                 940                 


Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
945                 950             


<210>  230
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Cys Asp Glu Asp Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Met Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Thr Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  231
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Ser Gly Asp Gly Ala Thr Glu Gln Ala Ala Glu Tyr Val Pro Glu 
1               5                   10                  15      


Lys Val Lys Lys Ala Glu Lys Lys Leu Glu Glu Asn Pro Tyr Asp Leu 
            20                  25                  30          


Asp Ala Trp Ser Ile Leu Ile Arg Glu Ala Gln Asn Gln Pro Ile Asp 
        35                  40                  45              


Lys Ala Arg Lys Thr Tyr Glu Arg Leu Val Ala Gln Phe Pro Ser Ser 
    50                  55                  60                  


Gly Arg Phe Trp Lys Leu Tyr Ile Glu Ala Glu Ile Lys Ala Lys Asn 
65                  70                  75                  80  


Tyr Asp Lys Val Glu Lys Leu Phe Gln Arg Cys Leu Met Lys Val Leu 
                85                  90                  95      


His Ile Asp Leu Trp Lys Cys Tyr Leu Ser Tyr Val Arg Glu Thr Lys 
            100                 105                 110         


Gly Lys Leu Pro Ser Tyr Lys Glu Lys Met Ala Gln Ala Tyr Asp Phe 
        115                 120                 125             


Ala Leu Asp Lys Ile Gly Met Glu Ile Met Ser Tyr Gln Ile Trp Val 
    130                 135                 140                 


Asp Tyr Ile Asn Phe Leu Lys Gly Val Glu Ala Val Gly Ser Tyr Ala 
145                 150                 155                 160 


Glu Asn Gln Arg Ile Thr Ala Val Arg Arg Val Tyr Gln Arg Gly Cys 
                165                 170                 175     


Val Asn Pro Met Ile Asn Ile Glu Gln Leu Trp Arg Asp Tyr Asn Lys 
            180                 185                 190         


Tyr Glu Glu Gly Ile Asn Ile His Leu Ala Lys Lys Met Ile Glu Asp 
        195                 200                 205             


Arg Ser Arg Asp Tyr Met Asn Ala Arg Arg Val Ala Lys Glu Tyr Glu 
    210                 215                 220                 


Thr Val Met Lys Gly Leu Asp Arg Asn Ala Pro Ser Val Pro Pro Gln 
225                 230                 235                 240 


Asn Thr Pro Gln Glu Ala Gln Gln Val Asp Met Trp Lys Lys Tyr Ile 
                245                 250                 255     


Gln Trp Glu Lys Ser Asn Pro Leu Arg Thr Glu Asp Gln Thr Leu Ile 
            260                 265                 270         


Thr Lys Arg Val Met Phe Ala Tyr Glu Gln Cys Leu Leu Val Leu Gly 
        275                 280                 285             


His His Pro Asp Ile Trp Tyr Glu Ala Ala Gln Tyr Leu Glu Gln Ser 
    290                 295                 300                 


Ser Lys Leu Leu Ala Glu Lys Gly Asp Met Asn Asn Ala Lys Leu Phe 
305                 310                 315                 320 


Ser Asp Glu Ala Ala Asn Ile Tyr Glu Arg Ala Ile Ser Thr Leu Leu 
                325                 330                 335     


Lys Lys Asn Met Leu Leu Tyr Phe Ala Tyr Ala Asp Tyr Glu Glu Ser 
            340                 345                 350         


Arg Met Lys Tyr Glu Lys Val His Ser Ile Tyr Asn Arg Leu Leu Ala 
        355                 360                 365             


Ile Glu Asp Ile Asp Pro Thr Leu Val Tyr Ile Gln Tyr Met Lys Phe 
    370                 375                 380                 


Ala Arg Arg Ala Glu Gly Ile Lys Ser Gly Arg Met Ile Phe Lys Lys 
385                 390                 395                 400 


Ala Arg Glu Asp Thr Arg Thr Arg His His Val Tyr Val Thr Ala Ala 
                405                 410                 415     


Leu Met Glu Tyr Tyr Cys Ser Lys Asp Lys Ser Val Ala Phe Lys Ile 
            420                 425                 430         


Phe Glu Leu Gly Leu Lys Lys Tyr Gly Asp Ile Pro Glu Tyr Val Leu 
        435                 440                 445             


Ala Tyr Ile Asp Tyr Leu Ser His Leu Asn Glu Asp Asn Asn Thr Arg 
    450                 455                 460                 


Val Leu Phe Glu Arg Val Leu Thr Ser Gly Ser Leu Pro Pro Glu Lys 
465                 470                 475                 480 


Ser Gly Glu Ile Trp Ala Arg Phe Leu Ala Phe Glu Ser Asn Ile Gly 
                485                 490                 495     


Asp Leu Ala Ser Ile Leu Lys Val Glu Lys Arg Arg Phe Thr Ala Phe 
            500                 505                 510         


Lys Glu Glu Tyr Glu Gly Lys Glu Thr Ala Leu Leu Val Asp Arg Tyr 
        515                 520                 525             


Lys Phe Met Asp Leu Tyr Pro Cys Ser Ala Ser Glu Leu Lys Ala Leu 
    530                 535                 540                 


Gly Tyr Lys Asp Val Ser Arg Ala Lys Leu Ala Ala Ile Ile Pro Asp 
545                 550                 555                 560 


Pro Val Val Ala Pro Ser Ile Val Pro Val Leu Lys Asp Glu Val Asp 
                565                 570                 575     


Arg Lys Pro Glu Tyr Pro Lys Pro Asp Thr Gln Gln Met Ile Pro Phe 
            580                 585                 590         


Gln Pro Arg His Leu Ala Pro Pro Gly Leu His Pro Val Pro Gly Gly 
        595                 600                 605             


Val Phe Pro Val Pro Pro Ala Ala Val Val Leu Met Lys Leu Leu Pro 
    610                 615                 620                 


Pro Pro Ile Cys Phe Gln Gly Pro Phe Val Gln Val Asp Glu Leu Met 
625                 630                 635                 640 


Glu Ile Phe Arg Arg Cys Lys Ile Pro Asn Thr Val Glu Glu Ala Val 
                645                 650                 655     


Arg Ile Ile Thr Gly Gly Ala Pro Glu Leu Ala Val Glu Gly Asn Gly 
            660                 665                 670         


Pro Val Glu Ser Asn Ala Val Leu Thr Lys Ala Val Lys Arg Pro Asn 
        675                 680                 685             


Glu Asp Ser Asp Glu Asp Glu Glu Lys Gly Ala Val Val Pro Pro Val 
    690                 695                 700                 


His Asp Ile Tyr Arg Ala Arg Gln Gln Lys Arg Ile Arg 
705                 710                 715         


<210>  232
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  233
<211>  4243
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Gly His Leu Trp Leu Leu Gly Ile Trp Gly Leu Cys Gly Leu Leu 
1               5                   10                  15      


Leu Cys Ala Ala Asp Pro Ser Thr Asp Gly Ser Gln Ile Ile Pro Lys 
            20                  25                  30          


Val Thr Glu Ile Ile Pro Lys Tyr Gly Ser Ile Asn Gly Ala Thr Arg 
        35                  40                  45              


Leu Thr Ile Arg Gly Glu Gly Phe Ser Gln Ala Asn Gln Phe Asn Tyr 
    50                  55                  60                  


Gly Val Asp Asn Ala Glu Leu Gly Asn Ser Val Gln Leu Ile Ser Ser 
65                  70                  75                  80  


Phe Gln Ser Ile Thr Cys Asp Val Glu Lys Asp Ala Ser His Ser Thr 
                85                  90                  95      


Gln Ile Thr Cys Tyr Thr Arg Ala Met Pro Glu Asp Ser Tyr Thr Val 
            100                 105                 110         


Arg Val Ser Val Asp Gly Val Pro Val Thr Glu Asn Asn Thr Cys Lys 
        115                 120                 125             


Gly His Ile Asn Ser Trp Glu Cys Thr Phe Asn Ala Lys Ser Phe Arg 
    130                 135                 140                 


Thr Pro Thr Ile Arg Ser Ile Thr Pro Leu Ser Gly Thr Pro Gly Thr 
145                 150                 155                 160 


Leu Ile Thr Ile Gln Gly Arg Ile Phe Thr Asp Val Tyr Gly Ser Asn 
                165                 170                 175     


Ile Ala Leu Ser Ser Asn Gly Lys Asn Val Arg Ile Leu Arg Val Tyr 
            180                 185                 190         


Ile Gly Gly Met Pro Cys Glu Leu Leu Ile Pro Gln Ser Asp Asn Leu 
        195                 200                 205             


Tyr Gly Leu Lys Leu Asp His Pro Asn Gly Asp Met Gly Ser Met Val 
    210                 215                 220                 


Cys Lys Thr Thr Gly Thr Phe Ile Gly His His Asn Val Ser Phe Ile 
225                 230                 235                 240 


Leu Asp Asn Asp Tyr Gly Arg Ser Phe Pro Gln Lys Met Ala Tyr Phe 
                245                 250                 255     


Val Ser Ser Leu Asn Lys Ile Ala Met Phe Gln Thr Tyr Ala Glu Val 
            260                 265                 270         


Thr Met Ile Phe Pro Ser Gln Gly Ser Ile Arg Gly Gly Thr Thr Leu 
        275                 280                 285             


Thr Ile Ser Gly Arg Phe Phe Asp Gln Thr Asp Phe Pro Val Arg Val 
    290                 295                 300                 


Leu Val Gly Gly Glu Pro Cys Asp Ile Leu Asn Val Thr Glu Asn Ser 
305                 310                 315                 320 


Ile Cys Cys Lys Thr Pro Pro Lys Pro His Ile Leu Lys Thr Val Tyr 
                325                 330                 335     


Pro Gly Gly Arg Gly Leu Lys Leu Glu Val Trp Asn Asn Ser Arg Pro 
            340                 345                 350         


Ile Arg Leu Glu Glu Ile Leu Glu Tyr Asn Glu Lys Thr Pro Gly Tyr 
        355                 360                 365             


Met Gly Ala Ser Trp Val Asp Ser Ala Ser Tyr Ile Trp Leu Met Glu 
    370                 375                 380                 


Gln Asp Thr Phe Val Ala Arg Phe Ser Gly Phe Leu Val Ala Pro Asp 
385                 390                 395                 400 


Ser Asp Val Tyr Arg Phe Tyr Ile Lys Gly Asp Asp Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Phe Ser Gln Thr Gly Leu Pro Glu Asp Lys Val Arg Ile Ala Tyr 
            420                 425                 430         


His Ser Ala Asn Ala Asn Ser Tyr Phe Ser Ser Pro Thr Gln Arg Ser 
        435                 440                 445             


Asp Asp Ile His Leu Gln Lys Gly Lys Glu Tyr Tyr Ile Glu Ile Leu 
    450                 455                 460                 


Leu Gln Glu Tyr Arg Leu Ser Ala Phe Val Asp Val Gly Leu Tyr Gln 
465                 470                 475                 480 


Tyr Arg Asn Val Tyr Thr Glu Gln Gln Thr Gly Asp Ala Val Asn Glu 
                485                 490                 495     


Glu Gln Val Ile Lys Ser Gln Ser Thr Ile Leu Gln Glu Val Gln Val 
            500                 505                 510         


Ile Thr Leu Glu Asn Trp Glu Thr Thr Asn Ala Ile Asn Glu Val Gln 
        515                 520                 525             


Lys Ile Lys Val Thr Ser Pro Cys Val Glu Ala Asn Ser Cys Ser Leu 
    530                 535                 540                 


Tyr Gln Tyr Arg Leu Ile Tyr Asn Met Glu Lys Thr Val Phe Leu Pro 
545                 550                 555                 560 


Ala Asp Ala Ser Glu Phe Ile Leu Gln Ser Ala Leu Asn Asp Leu Trp 
                565                 570                 575     


Ser Ile Lys Pro Asp Thr Val Gln Val Ile Arg Thr Gln Asn Pro Gln 
            580                 585                 590         


Ser Tyr Val Tyr Met Val Thr Phe Ile Ser Thr Arg Gly Asp Phe Asp 
        595                 600                 605             


Leu Leu Gly Tyr Glu Val Val Glu Gly Asn Asn Val Thr Leu Asp Ile 
    610                 615                 620                 


Thr Glu Gln Thr Lys Gly Lys Pro Asn Leu Glu Thr Phe Thr Leu Asn 
625                 630                 635                 640 


Trp Asp Gly Ile Ala Ser Lys Pro Leu Thr Leu Trp Ser Ser Glu Ala 
                645                 650                 655     


Glu Phe Gln Gly Ala Val Glu Glu Met Val Ser Thr Lys Cys Pro Pro 
            660                 665                 670         


Gln Ile Ala Asn Phe Glu Glu Gly Phe Val Val Lys Tyr Phe Arg Asp 
        675                 680                 685             


Tyr Glu Thr Asp Phe Asn Leu Glu His Ile Asn Arg Gly Gln Lys Thr 
    690                 695                 700                 


Ala Glu Thr Asp Ala Tyr Cys Gly Arg Tyr Ser Leu Lys Asn Pro Ala 
705                 710                 715                 720 


Val Leu Phe Asp Ser Ala Asp Val Lys Pro Asn Arg Arg Pro Tyr Gly 
                725                 730                 735     


Asp Ile Leu Leu Phe Pro Tyr Asn Gln Leu Cys Leu Ala Tyr Lys Gly 
            740                 745                 750         


Phe Leu Ala Asn Tyr Ile Gly Leu Lys Phe Gln Tyr Gln Asp Asn Ser 
        755                 760                 765             


Lys Ile Thr Arg Ser Thr Asp Thr Gln Phe Thr Tyr Asn Phe Ala Tyr 
    770                 775                 780                 


Gly Asn Asn Trp Thr Tyr Thr Cys Ile Asp Leu Leu Asp Leu Val Arg 
785                 790                 795                 800 


Thr Lys Tyr Thr Gly Thr Asn Val Ser Leu Gln Arg Ile Ser Leu His 
                805                 810                 815     


Lys Ala Ser Glu Ser Gln Ser Phe Tyr Val Asp Val Val Tyr Ile Gly 
            820                 825                 830         


His Thr Ser Thr Ile Ser Thr Leu Asp Glu Met Pro Lys Arg Arg Leu 
        835                 840                 845             


Pro Ala Leu Ala Asn Lys Gly Ile Phe Leu Glu His Phe Gln Val Asn 
    850                 855                 860                 


Gln Thr Lys Thr Asn Gly Pro Thr Met Thr Asn Gln Tyr Ser Val Thr 
865                 870                 875                 880 


Met Thr Ser Tyr Asn Cys Ser Tyr Asn Ile Pro Met Met Ala Val Ser 
                885                 890                 895     


Phe Gly Gln Ile Ile Thr His Glu Thr Glu Asn Glu Phe Val Tyr Arg 
            900                 905                 910         


Gly Asn Asn Trp Pro Gly Glu Ser Lys Ile His Ile Gln Arg Ile Gln 
        915                 920                 925             


Ala Ala Ser Pro Pro Leu Ser Gly Ser Phe Asp Ile Gln Ala Tyr Gly 
    930                 935                 940                 


His Ile Leu Lys Gly Leu Pro Ala Ala Val Ser Ala Ala Asp Leu Gln 
945                 950                 955                 960 


Phe Ala Leu Gln Ser Leu Glu Gly Met Gly Arg Ile Ser Val Thr Arg 
                965                 970                 975     


Glu Gly Thr Cys Ala Gly Tyr Ala Trp Asn Ile Lys Trp Arg Ser Thr 
            980                 985                 990         


Cys Gly Lys Gln Asn Leu Leu Gln  Ile Asn Asp Ser Asn  Ile Ile Gly 
        995                 1000                 1005             


Glu Lys  Ala Asn Met Thr Val  Thr Arg Ile Lys Glu  Gly Gly Leu 
    1010                 1015                 1020             


Phe Arg  Gln His Val Leu Gly  Asp Leu Leu Arg Thr  Pro Ser Gln 
    1025                 1030                 1035             


Gln Pro  Gln Val Glu Val Tyr  Val Asn Gly Ile Pro  Ala Lys Cys 
    1040                 1045                 1050             


Ser Gly  Asp Cys Gly Phe Thr  Trp Asp Ser Asn Ile  Thr Pro Leu 
    1055                 1060                 1065             


Val Leu  Ala Ile Ser Pro Ser  Gln Gly Ser Tyr Glu  Glu Gly Thr 
    1070                 1075                 1080             


Ile Leu  Thr Ile Val Gly Ser  Gly Phe Ser Pro Ser  Ser Ala Val 
    1085                 1090                 1095             


Thr Val  Ser Val Gly Pro Val  Gly Cys Ser Leu Leu  Ser Val Asp 
    1100                 1105                 1110             


Glu Lys  Glu Leu Lys Cys Gln  Ile Leu Asn Gly Ser  Ala Gly His 
    1115                 1120                 1125             


Ala Pro  Val Ala Val Ser Met  Ala Asp Val Gly Leu  Ala Gln Asn 
    1130                 1135                 1140             


Val Gly  Gly Glu Glu Phe Tyr  Phe Val Tyr Gln Ser  Gln Ile Ser 
    1145                 1150                 1155             


His Ile  Trp Pro Asp Ser Gly  Ser Ile Ala Gly Gly  Thr Leu Leu 
    1160                 1165                 1170             


Thr Leu  Ser Gly Phe Gly Phe  Asn Glu Asn Ser Lys  Val Leu Val 
    1175                 1180                 1185             


Gly Asn  Glu Thr Cys Asn Val  Ile Glu Gly Asp Leu  Asn Arg Ile 
    1190                 1195                 1200             


Thr Cys  Arg Thr Pro Lys Lys  Thr Glu Gly Thr Val  Asp Ile Ser 
    1205                 1210                 1215             


Val Thr  Thr Asn Gly Phe Gln  Ala Thr Ala Arg Asp  Ala Phe Ser 
    1220                 1225                 1230             


Tyr Asn  Cys Leu Gln Thr Pro  Ile Ile Thr Asp Phe  Ser Pro Lys 
    1235                 1240                 1245             


Val Arg  Thr Ile Leu Gly Glu  Val Asn Leu Thr Ile  Lys Gly Tyr 
    1250                 1255                 1260             


Asn Phe  Gly Asn Glu Leu Thr  Gln Asn Met Ala Val  Tyr Val Gly 
    1265                 1270                 1275             


Gly Lys  Thr Cys Gln Ile Leu  His Trp Asn Phe Thr  Asp Ile Arg 
    1280                 1285                 1290             


Cys Leu  Leu Pro Lys Leu Ser  Pro Gly Lys His Asp  Ile Tyr Val 
    1295                 1300                 1305             


Glu Val  Arg Asn Trp Gly Phe  Ala Ser Thr Arg Asp  Lys Leu Asn 
    1310                 1315                 1320             


Ser Ser  Ile Gln Tyr Val Leu  Glu Val Thr Ser Met  Phe Pro Gln 
    1325                 1330                 1335             


Arg Gly  Ser Leu Phe Gly Gly  Thr Glu Ile Thr Ile  Arg Gly Phe 
    1340                 1345                 1350             


Gly Phe  Ser Thr Ile Pro Ala  Glu Asn Thr Val Leu  Leu Gly Ser 
    1355                 1360                 1365             


Ile Pro  Cys Asn Val Thr Ser  Ser Ser Glu Asn Val  Ile Lys Cys 
    1370                 1375                 1380             


Ile Leu  His Ser Thr Gly Asn  Ile Phe Arg Ile Thr  Asn Asn Gly 
    1385                 1390                 1395             


Lys Asp  Ser Val His Gly Leu  Gly Tyr Ala Trp Ser  Pro Pro Val 
    1400                 1405                 1410             


Leu Asn  Val Ser Val Gly Asp  Thr Val Ala Trp His  Trp Gln Thr 
    1415                 1420                 1425             


His Pro  Phe Leu Arg Gly Ile  Gly Tyr Arg Ile Phe  Ser Val Ser 
    1430                 1435                 1440             


Ser Pro  Gly Ser Val Ile Tyr  Asp Gly Lys Gly Phe  Thr Ser Gly 
    1445                 1450                 1455             


Arg Gln  Lys Ser Thr Ser Gly  Ser Phe Ser Tyr Gln  Phe Thr Ser 
    1460                 1465                 1470             


Pro Gly  Ile His Tyr Tyr Ser  Ser Gly Tyr Val Asp  Glu Ala His 
    1475                 1480                 1485             


Ser Ile  Phe Leu Gln Gly Val  Ile Asn Val Leu Pro  Ala Glu Thr 
    1490                 1495                 1500             


Arg His  Ile Pro Leu His Leu  Phe Val Gly Arg Ser  Glu Ala Thr 
    1505                 1510                 1515             


Tyr Ala  Tyr Gly Gly Pro Glu  Asn Leu His Leu Gly  Ser Ser Val 
    1520                 1525                 1530             


Ala Gly  Cys Leu Ala Thr Glu  Pro Leu Cys Ser Leu  Asn Asn Thr 
    1535                 1540                 1545             


Arg Val  Lys Asn Ser Lys Arg  Leu Leu Phe Glu Val  Ser Ser Cys 
    1550                 1555                 1560             


Phe Ser  Pro Ser Ile Ser Asn  Ile Thr Pro Ser Thr  Gly Thr Val 
    1565                 1570                 1575             


Asn Glu  Leu Ile Thr Ile Ile  Gly His Gly Phe Ser  Asn Leu Pro 
    1580                 1585                 1590             


Trp Ala  Asn Lys Val Thr Ile  Gly Ser Tyr Pro Cys  Val Val Glu 
    1595                 1600                 1605             


Glu Ser  Ser Glu Asp Ser Ile  Thr Cys His Ile Asp  Pro Gln Asn 
    1610                 1615                 1620             


Ser Met  Asp Val Gly Ile Arg  Glu Thr Val Thr Leu  Thr Val Tyr 
    1625                 1630                 1635             


Asn Leu  Gly Thr Ala Ile Asn  Thr Leu Ser Asn Glu  Phe Asp Arg 
    1640                 1645                 1650             


Arg Phe  Val Leu Leu Pro Asn  Ile Asp Leu Val Leu  Pro Asn Ala 
    1655                 1660                 1665             


Gly Ser  Thr Thr Gly Met Thr  Ser Val Thr Ile Lys  Gly Ser Gly 
    1670                 1675                 1680             


Phe Ala  Val Ser Ser Ala Gly  Val Lys Val Leu Met  Gly His Phe 
    1685                 1690                 1695             


Pro Cys  Lys Val Leu Ser Val  Asn Tyr Thr Ala Ile  Glu Cys Glu 
    1700                 1705                 1710             


Thr Ser  Pro Ala Ala Gln Gln  Leu Val Asp Val Asp  Leu Leu Ile 
    1715                 1720                 1725             


His Gly  Val Pro Ala Gln Cys  Gln Gly Asn Cys Thr  Phe Ser Tyr 
    1730                 1735                 1740             


Leu Glu  Ser Ile Thr Pro Tyr  Ile Thr Gly Val Phe  Pro Asn Ser 
    1745                 1750                 1755             


Val Ile  Gly Ser Val Lys Val  Leu Ile Glu Gly Glu  Gly Leu Gly 
    1760                 1765                 1770             


Thr Val  Leu Glu Asp Ile Ala  Val Phe Ile Gly Asn  Gln Gln Phe 
    1775                 1780                 1785             


Arg Ala  Ile Glu Val Asn Glu  Asn Asn Ile Thr Ala  Leu Val Thr 
    1790                 1795                 1800             


Pro Leu  Pro Val Gly His His  Ser Val Ser Val Val  Val Gly Ser 
    1805                 1810                 1815             


Lys Gly  Leu Ala Leu Gly Asn  Leu Thr Val Ser Ser  Pro Pro Val 
    1820                 1825                 1830             


Ala Ser  Leu Ser Pro Thr Ser  Gly Ser Ile Gly Gly  Gly Thr Thr 
    1835                 1840                 1845             


Leu Val  Ile Thr Gly Asn Gly  Phe Tyr Pro Gly Asn  Thr Thr Val 
    1850                 1855                 1860             


Thr Ile  Gly Asp Glu Pro Cys  Gln Ile Ile Ser Ile  Asn Pro Asn 
    1865                 1870                 1875             


Glu Val  Tyr Cys Arg Thr Pro  Ala Gly Thr Thr Gly  Met Val Asp 
    1880                 1885                 1890             


Val Lys  Ile Phe Val Asn Thr  Ile Ala Tyr Pro Pro  Leu Leu Phe 
    1895                 1900                 1905             


Thr Tyr  Ala Leu Glu Asp Thr  Pro Phe Leu Arg Gly  Ile Ile Pro 
    1910                 1915                 1920             


Ser Arg  Gly Pro Pro Gly Thr  Glu Ile Glu Ile Thr  Gly Ser Asn 
    1925                 1930                 1935             


Phe Gly  Phe Glu Ile Leu Glu  Ile Ser Val Met Ile  Asn Asn Ile 
    1940                 1945                 1950             


Gln Cys  Asn Val Thr Met Ala  Asn Asp Ser Val Val  Gln Cys Ile 
    1955                 1960                 1965             


Val Gly  Asp His Ala Gly Gly  Thr Phe Pro Val Met  Met His His 
    1970                 1975                 1980             


Lys Thr  Lys Gly Ser Ala Met  Ser Thr Val Val Phe  Glu Tyr Pro 
    1985                 1990                 1995             


Leu Asn  Ile Gln Asn Ile Asn  Pro Ser Gln Gly Ser  Phe Gly Gly 
    2000                 2005                 2010             


Gly Gln  Thr Met Thr Val Thr  Gly Thr Gly Phe Asn  Pro Gln Asn 
    2015                 2020                 2025             


Ser Ile  Ile Leu Val Cys Gly  Ser Glu Cys Ala Ile  Asp Arg Leu 
    2030                 2035                 2040             


Arg Ser  Asp Tyr Thr Thr Leu  Leu Cys Glu Ile Pro  Ser Asn Asn 
    2045                 2050                 2055             


Gly Thr  Gly Ala Glu Gln Ala  Cys Glu Val Ser Val  Val Asn Gly 
    2060                 2065                 2070             


Lys Asp  Leu Ser Gln Ser Met  Thr Pro Phe Thr Tyr  Ala Val Ser 
    2075                 2080                 2085             


Leu Thr  Pro Leu Ile Thr Ala  Val Ser Pro Lys Arg  Gly Ser Thr 
    2090                 2095                 2100             


Ala Gly  Gly Thr Arg Leu Thr  Val Val Gly Ser Gly  Phe Ser Glu 
    2105                 2110                 2115             


Asn Met  Glu Asp Val His Ile  Thr Ile Ala Glu Ala  Lys Cys Asp 
    2120                 2125                 2130             


Val Glu  Tyr Ser Asn Lys Thr  His Ile Ile Cys Met  Thr Asp Ala 
    2135                 2140                 2145             


His Thr  Leu Ser Gly Trp Ala  Pro Val Cys Val His  Ile Arg Gly 
    2150                 2155                 2160             


Val Gly  Met Ala Lys Leu Asp  Asn Ala Asp Phe Leu  Tyr Val Asp 
    2165                 2170                 2175             


Ala Trp  Ser Ser Asn Phe Ser  Trp Gly Gly Lys Ser  Pro Pro Glu 
    2180                 2185                 2190             


Glu Gly  Ser Leu Val Val Ile  Thr Lys Gly Gln Thr  Ile Leu Leu 
    2195                 2200                 2205             


Asp Gln  Ser Thr Pro Ile Leu  Lys Met Leu Leu Ile  Gln Gly Gly 
    2210                 2215                 2220             


Thr Leu  Ile Phe Asp Glu Ala  Asp Ile Glu Leu Gln  Ala Glu Asn 
    2225                 2230                 2235             


Ile Leu  Ile Thr Asp Gly Gly  Val Leu Gln Ile Gly  Thr Glu Thr 
    2240                 2245                 2250             


Ser Pro  Phe Gln His Lys Ala  Val Ile Thr Leu His  Gly His Leu 
    2255                 2260                 2265             


Arg Ser  Pro Glu Leu Pro Val  Tyr Gly Ala Lys Thr  Leu Ala Val 
    2270                 2275                 2280             


Arg Glu  Gly Ile Leu Asp Leu  His Gly Val Pro Val  Pro Val Thr 
    2285                 2290                 2295             


Trp Thr  Arg Leu Ala His Thr  Ala Lys Ala Gly Glu  Arg Ile Leu 
    2300                 2305                 2310             


Ile Leu  Gln Glu Ala Val Thr  Trp Lys Pro Gly Asp  Asn Ile Val 
    2315                 2320                 2325             


Ile Ala  Ser Thr Gly His Arg  His Ser Gln Gly Glu  Asn Glu Lys 
    2330                 2335                 2340             


Met Thr  Ile Ala Ser Val Ser  Ala Asp Gly Ile Asn  Ile Thr Leu 
    2345                 2350                 2355             


Ser Asn  Pro Leu Asn Tyr Thr  His Leu Gly Ile Thr  Val Thr Leu 
    2360                 2365                 2370             


Pro Asp  Gly Thr Leu Phe Glu  Ala Arg Ala Glu Val  Gly Ile Leu 
    2375                 2380                 2385             


Thr Arg  Asn Ile Leu Ile Arg  Gly Ser Asp Asn Val  Glu Trp Asn 
    2390                 2395                 2400             


Asn Lys  Ile Pro Ala Cys Pro  Asp Gly Phe Asp Thr  Gly Glu Phe 
    2405                 2410                 2415             


Ala Thr  Gln Thr Cys Leu Gln  Gly Lys Phe Gly Glu  Glu Ile Gly 
    2420                 2425                 2430             


Ser Asp  Gln Phe Gly Gly Cys  Val Met Phe His Ala  Pro Val Pro 
    2435                 2440                 2445             


Gly Ala  Asn Met Val Thr Gly  Arg Ile Glu Tyr Val  Glu Val Phe 
    2450                 2455                 2460             


His Ala  Gly Gln Ala Phe Arg  Leu Gly Arg Tyr Pro  Ile His Trp 
    2465                 2470                 2475             


His Leu  Leu Gly Asp Leu Gln  Phe Lys Ser Tyr Val  Arg Gly Cys 
    2480                 2485                 2490             


Ala Ile  His Gln Ala Tyr Asn  Arg Ala Val Thr Ile  His Asn Thr 
    2495                 2500                 2505             


His His  Leu Leu Val Glu Arg  Asn Ile Ile Tyr Asp  Ile Lys Gly 
    2510                 2515                 2520             


Gly Ala  Phe Phe Ile Glu Asp  Gly Ile Glu His Gly  Asn Ile Leu 
    2525                 2530                 2535             


Gln Tyr  Asn Leu Ala Val Phe  Val Gln Gln Ser Thr  Ser Leu Leu 
    2540                 2545                 2550             


Asn Asp  Asp Val Thr Pro Ala  Ala Phe Trp Val Thr  Asn Pro Asn 
    2555                 2560                 2565             


Asn Thr  Ile Arg His Asn Ala  Val Ala Gly Gly Thr  His Phe Gly 
    2570                 2575                 2580             


Phe Trp  Tyr Arg Met Asn Asn  His Pro Asp Gly Pro  Ser Tyr Asp 
    2585                 2590                 2595             


Arg Asn  Ile Cys Gln Lys Arg  Val Pro Leu Gly Glu  Phe Phe Asn 
    2600                 2605                 2610             


Asn Thr  Val His Ser Gln Gly  Trp Phe Gly Met Trp  Ile Phe Glu 
    2615                 2620                 2625             


Glu Tyr  Phe Pro Met Gln Thr  Gly Ser Cys Thr Ser  Thr Val Pro 
    2630                 2635                 2640             


Ala Pro  Ala Ile Phe Asn Ser  Leu Thr Thr Trp Asn  Cys Gln Lys 
    2645                 2650                 2655             


Gly Ala  Glu Trp Val Asn Gly  Gly Ala Leu Gln Phe  His Asn Phe 
    2660                 2665                 2670             


Val Met  Val Asn Asn Tyr Glu  Ala Gly Ile Glu Thr  Lys Arg Ile 
    2675                 2680                 2685             


Leu Ala  Pro Tyr Val Gly Gly  Trp Gly Glu Thr Asn  Gly Ala Val 
    2690                 2695                 2700             


Ile Lys  Asn Ala Lys Ile Val  Gly His Leu Asp Glu  Leu Gly Met 
    2705                 2710                 2715             


Gly Ser  Ala Phe Cys Thr Ala  Lys Gly Leu Val Leu  Pro Phe Ser 
    2720                 2725                 2730             


Glu Gly  Leu Thr Val Ser Ser  Val His Phe Met Asn  Phe Asp Arg 
    2735                 2740                 2745             


Pro Asn  Cys Val Ala Leu Gly  Val Thr Ser Ile Ser  Gly Val Cys 
    2750                 2755                 2760             


Asn Asp  Arg Cys Gly Gly Trp  Ser Ala Lys Phe Val  Asp Val Gln 
    2765                 2770                 2775             


Tyr Ser  His Thr Pro Asn Lys  Ala Gly Phe Arg Trp  Glu His Glu 
    2780                 2785                 2790             


Met Val  Met Ile Asp Val Asp  Gly Ser Leu Thr Gly  His Lys Gly 
    2795                 2800                 2805             


His Thr  Val Ile Pro His Ser  Ser Leu Leu Asp Pro  Ser His Cys 
    2810                 2815                 2820             


Thr Gln  Glu Ala Glu Trp Ser  Ile Gly Phe Pro Gly  Ser Val Cys 
    2825                 2830                 2835             


Asp Ala  Ser Val Ser Phe His  Arg Leu Ala Phe Asn  Gln Pro Ser 
    2840                 2845                 2850             


Pro Val  Ser Leu Leu Glu Lys  Asp Val Val Leu Ser  Asp Ser Phe 
    2855                 2860                 2865             


Gly Thr  Ser Ile Ile Pro Phe  Gln Lys Lys Arg Leu  Thr His Met 
    2870                 2875                 2880             


Ser Gly  Trp Met Ala Leu Ile  Pro Asn Ala Asn His  Ile Asn Trp 
    2885                 2890                 2895             


Tyr Phe  Lys Gly Val Asp His  Ile Thr Asn Ile Ser  Tyr Thr Ser 
    2900                 2905                 2910             


Thr Phe  Tyr Gly Phe Lys Glu  Glu Asp Tyr Val Ile  Ile Ser His 
    2915                 2920                 2925             


Asn Phe  Thr Gln Asn Pro Asp  Met Phe Asn Ile Ile  Asp Met Arg 
    2930                 2935                 2940             


Asn Gly  Ser Ser Asn Pro Leu  Asn Trp Asn Thr Ser  Lys Asn Gly 
    2945                 2950                 2955             


Asp Trp  His Leu Glu Ala Asn  Thr Ser Thr Leu Tyr  Tyr Leu Val 
    2960                 2965                 2970             


Ser Gly  Arg Asn Asp Leu His  Gln Ser Gln Leu Ile  Ser Gly Asn 
    2975                 2980                 2985             


Leu Asp  Pro Asp Val Lys Asp  Val Val Ile Asn Phe  Gln Ala Tyr 
    2990                 2995                 3000             


Cys Cys  Ile Leu Gln Asp Cys  Phe Pro Val His Pro  Pro Ser Arg 
    3005                 3010                 3015             


Lys Pro  Ile Pro Lys Lys Arg  Pro Ala Thr Tyr Asn  Leu Trp Ser 
    3020                 3025                 3030             


Asn Asp  Ser Phe Trp Gln Ser  Ser Arg Glu Asn Asn  Tyr Thr Val 
    3035                 3040                 3045             


Pro His  Pro Gly Ala Asn Val  Ile Ile Pro Glu Gly  Thr Trp Ile 
    3050                 3055                 3060             


Val Ala  Asp Ile Asp Met Pro  Ser Met Glu Arg Leu  Ile Ile Trp 
    3065                 3070                 3075             


Gly Val  Leu Glu Leu Glu Asp  Lys Tyr Asn Val Gly  Ala Ala Glu 
    3080                 3085                 3090             


Ser Ser  Tyr Arg Glu Val Val  Leu Asn Ala Thr Tyr  Ile Ser Leu 
    3095                 3100                 3105             


Gln Gly  Gly Arg Leu Ile Gly  Gly Trp Glu Asp Asn  Pro Phe Lys 
    3110                 3115                 3120             


Gly Asp  Leu Lys Ile Val Leu  Arg Gly Asn His Thr  Thr Gln Asp 
    3125                 3130                 3135             


Trp Ala  Leu Pro Glu Gly Pro  Asn Gln Gly Ala Lys  Val Leu Gly 
    3140                 3145                 3150             


Val Phe  Gly Glu Leu Asp Leu  His Gly Ile Pro His  Ser Ile Tyr 
    3155                 3160                 3165             


Lys Thr  Lys Leu Ser Glu Thr  Ala Phe Ala Gly Ser  Lys Val Leu 
    3170                 3175                 3180             


Ser Leu  Met Asp Ala Val Asp  Trp Gln Glu Gly Glu  Glu Ile Val 
    3185                 3190                 3195             


Ile Thr  Thr Thr Ser Tyr Asp  Phe His Gln Thr Glu  Thr Arg Ser 
    3200                 3205                 3210             


Ile Val  Lys Ile Leu His Asp  His Lys Ile Leu Ile  Leu Asn Asp 
    3215                 3220                 3225             


Ser Leu  Ser Tyr Thr His Phe  Ala Glu Lys Tyr His  Val Pro Gly 
    3230                 3235                 3240             


Thr Gly  Glu Ser Tyr Thr Leu  Ala Ala Asp Val Gly  Ile Leu Ser 
    3245                 3250                 3255             


Arg Asn  Ile Lys Ile Val Gly  Glu Asp Tyr Pro Gly  Trp Ser Glu 
    3260                 3265                 3270             


Asp Ser  Phe Gly Ala Arg Val  Leu Val Gly Ser Phe  Thr Glu Asn 
    3275                 3280                 3285             


Met Met  Thr Phe Lys Gly Asn  Ala Arg Ile Ser Asn  Val Glu Phe 
    3290                 3295                 3300             


Tyr His  Ser Gly Gln Glu Gly  Phe Arg Asp Ser Thr  Asp Pro Arg 
    3305                 3310                 3315             


Tyr Ala  Val Thr Phe Leu Asn  Leu Gly Gln Ile Gln  Glu His Gly 
    3320                 3325                 3330             


Ser Ser  Tyr Ile Arg Gly Cys  Ala Phe His His Gly  Phe Ser Pro 
    3335                 3340                 3345             


Ala Ile  Gly Val Phe Gly Thr  Asp Gly Leu Asp Ile  Asp Asp Asn 
    3350                 3355                 3360             


Ile Ile  His Phe Thr Val Gly  Glu Gly Ile Arg Ile  Trp Gly Asn 
    3365                 3370                 3375             


Ala Asn  Arg Val Arg Gly Asn  Leu Ile Ala Leu Ser  Val Trp Pro 
    3380                 3385                 3390             


Gly Thr  Tyr Gln Asn Arg Lys  Asp Leu Ser Ser Thr  Leu Trp His 
    3395                 3400                 3405             


Ala Ala  Ile Glu Ile Asn Arg  Gly Thr Asn Thr Val  Leu Gln Asn 
    3410                 3415                 3420             


Asn Val  Val Ala Gly Phe Gly  Arg Ala Gly Tyr Arg  Ile Asp Gly 
    3425                 3430                 3435             


Glu Pro  Cys Pro Gly Gln Phe  Asn Pro Val Glu Lys  Trp Phe Asp 
    3440                 3445                 3450             


Asn Glu  Ala His Gly Gly Leu  Tyr Gly Ile Tyr Met  Asn Gln Asp 
    3455                 3460                 3465             


Gly Leu  Pro Gly Cys Ser Leu  Ile Gln Gly Phe Thr  Ile Trp Thr 
    3470                 3475                 3480             


Cys Trp  Asp Tyr Gly Ile Tyr  Phe Gln Thr Thr Glu  Ser Val His 
    3485                 3490                 3495             


Ile Tyr  Asn Val Thr Leu Val  Asp Asn Gly Met Ala  Ile Phe Pro 
    3500                 3505                 3510             


Met Ile  Tyr Met Pro Ala Ala  Ile Ser His Lys Ile  Ser Ser Lys 
    3515                 3520                 3525             


Asn Val  Gln Ile Lys Ser Ser  Leu Ile Val Gly Ser  Ser Pro Gly 
    3530                 3535                 3540             


Phe Asn  Cys Ser Asp Val Leu  Thr Asn Asp Asp Pro  Asn Ile Glu 
    3545                 3550                 3555             


Leu Thr  Ala Ala His Arg Ser  Pro Arg Ser Pro Ser  Gly Gly Arg 
    3560                 3565                 3570             


Ser Gly  Ile Cys Trp Pro Thr  Phe Ala Ser Ala His  Asn Met Ala 
    3575                 3580                 3585             


Pro Arg  Lys Pro His Ala Gly  Ile Met Ser Tyr Asn  Ala Ile Ser 
    3590                 3595                 3600             


Gly Leu  Leu Asp Ile Ser Gly  Ser Thr Phe Val Gly  Phe Lys Asn 
    3605                 3610                 3615             


Val Cys  Ser Gly Glu Thr Asn  Val Ile Phe Ile Thr  Asn Pro Leu 
    3620                 3625                 3630             


Asn Glu  Asp Leu Gln His Pro  Ile His Val Lys Asn  Ile Lys Leu 
    3635                 3640                 3645             


Val Asp  Thr Thr Glu Gln Ser  Lys Ile Phe Ile His  Arg Pro Asp 
    3650                 3655                 3660             


Ile Ser  Lys Val Asn Pro Ser  Asp Cys Val Asp Met  Val Cys Asp 
    3665                 3670                 3675             


Ala Lys  Arg Lys Ser Phe Leu  Arg Asp Ile Asp Gly  Ser Phe Leu 
    3680                 3685                 3690             


Gly Asn  Ala Gly Ser Val Ile  Pro Gln Ala Glu Tyr  Glu Trp Asp 
    3695                 3700                 3705             


Gly Asn  Ser Gln Val Gly Ile  Gly Asp Tyr Arg Ile  Pro Lys Ala 
    3710                 3715                 3720             


Met Leu  Thr Phe Leu Asn Gly  Ser Arg Ile Pro Val  Thr Glu Lys 
    3725                 3730                 3735             


Ala Pro  His Lys Gly Ile Ile  Arg Asp Ser Thr Cys  Lys Tyr Leu 
    3740                 3745                 3750             


Pro Glu  Trp Gln Ser Tyr Gln  Cys Phe Gly Met Glu  Tyr Ala Met 
    3755                 3760                 3765             


Met Val  Ile Glu Ser Leu Asp  Pro Asp Thr Glu Thr  Arg Arg Leu 
    3770                 3775                 3780             


Ser Pro  Val Ala Ile Met Gly  Asn Gly Tyr Val Asp  Leu Ile Asn 
    3785                 3790                 3795             


Gly Pro  Gln Asp His Gly Trp  Cys Ala Gly Tyr Thr  Cys Gln Arg 
    3800                 3805                 3810             


Arg Leu  Ser Leu Phe His Ser  Ile Val Ala Leu Asn  Lys Ser Tyr 
    3815                 3820                 3825             


Glu Val  Tyr Phe Thr Gly Thr  Ser Pro Gln Asn Leu  Arg Leu Met 
    3830                 3835                 3840             


Leu Leu  Asn Val Asp His Asn  Lys Ala Val Leu Val  Gly Ile Phe 
    3845                 3850                 3855             


Phe Ser  Thr Leu Gln Arg Leu  Asp Val Tyr Val Asn  Asn Leu Leu 
    3860                 3865                 3870             


Val Cys  Pro Lys Thr Thr Ile  Trp Asn Ala Gln Gln  Lys His Cys 
    3875                 3880                 3885             


Glu Leu  Asn Asn His Leu Tyr  Lys Asp Gln Phe Leu  Pro Asn Leu 
    3890                 3895                 3900             


Asp Ser  Thr Val Leu Gly Glu  Asn Tyr Phe Asp Gly  Thr Tyr Gln 
    3905                 3910                 3915             


Met Leu  Tyr Leu Leu Val Lys  Gly Thr Ile Pro Val  Glu Ile His 
    3920                 3925                 3930             


Thr Ala  Thr Val Ile Phe Val  Ser Phe Gln Leu Ser  Val Ala Thr 
    3935                 3940                 3945             


Glu Asp  Asp Phe Tyr Thr Ser  His Asn Leu Val Lys  Asn Leu Ala 
    3950                 3955                 3960             


Leu Phe  Leu Lys Ile Pro Ser  Asp Lys Ile Arg Ile  Ser Lys Ile 
    3965                 3970                 3975             


Arg Gly  Lys Ser Leu Arg Arg  Lys Arg Ser Met Gly  Phe Ile Ile 
    3980                 3985                 3990             


Glu Ile  Glu Ile Gly Asp Pro  Pro Ile Gln Phe Ile  Ser Asn Gly 
    3995                 4000                 4005             


Thr Thr  Gly Gln Met Gln Leu  Ser Glu Leu Gln Glu  Ile Ala Gly 
    4010                 4015                 4020             


Ser Leu  Gly Gln Ala Val Ile  Leu Gly Asn Ile Ser  Ser Ile Leu 
    4025                 4030                 4035             


Gly Phe  Asn Ile Ser Ser Met  Ser Ile Thr Asn Pro  Leu Pro Ser 
    4040                 4045                 4050             


Pro Ser  Asp Ser Gly Trp Ile  Lys Val Thr Ala Gln  Pro Val Glu 
    4055                 4060                 4065             


Arg Ser  Ala Phe Pro Val His  His Val Ala Phe Val  Ser Ser Leu 
    4070                 4075                 4080             


Leu Val  Ile Thr Gln Pro Val  Ala Ala Gln Pro Gly  Gln Pro Phe 
    4085                 4090                 4095             


Pro Gln  Gln Pro Ser Val Lys  Ala Thr Asp Ser Asp  Gly Asn Cys 
    4100                 4105                 4110             


Val Ser  Val Gly Ile Thr Ala  Leu Thr Leu Arg Ala  Ile Leu Lys 
    4115                 4120                 4125             


Asp Ser  Asn Asn Asn Gln Val  Asn Gly Leu Ser Gly  Asn Thr Thr 
    4130                 4135                 4140             


Ile Pro  Phe Ser Ser Cys Trp  Ala Asn Tyr Thr Asp  Leu Thr Pro 
    4145                 4150                 4155             


Leu Arg  Thr Gly Lys Asn Tyr  Lys Ile Glu Phe Ile  Leu Asp Asn 
    4160                 4165                 4170             


Val Val  Gly Val Glu Ser Arg  Thr Phe Ser Leu Leu  Ala Glu Ser 
    4175                 4180                 4185             


Val Ser  Ser Ser Gly Ser Ser  Ser Ser Ser Asn Ser  Lys Ala Ser 
    4190                 4195                 4200             


Thr Val  Gly Thr Tyr Ala Gln  Ile Met Thr Val Val  Ile Ser Cys 
    4205                 4210                 4215             


Leu Val  Gly Arg Met Trp Leu  Leu Glu Ile Phe Met  Ala Ala Val 
    4220                 4225                 4230             


Ser Thr  Leu Asn Ile Thr Leu  Arg Ser Tyr 
    4235                 4240             


<210>  234
<211>  1801
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Pro Glu Asn Pro Ala Thr Asp Lys Leu Gln Val Leu Gln Val Leu 
1               5                   10                  15      


Asp Arg Leu Lys Met Lys Leu Gln Glu Lys Gly Asp Thr Ser Gln Asn 
            20                  25                  30          


Glu Lys Leu Ser Met Phe Tyr Glu Thr Leu Lys Ser Pro Leu Phe Asn 
        35                  40                  45              


Gln Ile Leu Thr Leu Gln Gln Ser Ile Lys Gln Leu Lys Gly Gln Leu 
    50                  55                  60                  


Asn His Ile Pro Ser Asp Cys Ser Ala Asn Phe Asp Phe Ser Arg Lys 
65                  70                  75                  80  


Gly Leu Leu Val Phe Thr Asp Gly Ser Ile Thr Asn Gly Asn Val His 
                85                  90                  95      


Arg Pro Ser Asn Asn Ser Thr Val Ser Gly Leu Phe Pro Trp Thr Pro 
            100                 105                 110         


Lys Leu Gly Asn Glu Asp Phe Asn Ser Val Ile Gln Gln Met Ala Gln 
        115                 120                 125             


Gly Arg Gln Ile Glu Tyr Ile Asp Ile Glu Arg Pro Ser Thr Gly Gly 
    130                 135                 140                 


Leu Gly Phe Ser Val Val Ala Leu Arg Ser Gln Asn Leu Gly Lys Val 
145                 150                 155                 160 


Asp Ile Phe Val Lys Asp Val Gln Pro Gly Ser Val Ala Asp Arg Asp 
                165                 170                 175     


Gln Arg Leu Lys Glu Asn Asp Gln Ile Leu Ala Ile Asn His Thr Pro 
            180                 185                 190         


Leu Asp Gln Asn Ile Ser His Gln Gln Ala Ile Ala Leu Leu Gln Gln 
        195                 200                 205             


Thr Thr Gly Ser Leu Arg Leu Ile Val Ala Arg Glu Pro Val His Thr 
    210                 215                 220                 


Lys Ser Ser Thr Ser Ser Ser Leu Asn Asp Thr Thr Leu Pro Glu Thr 
225                 230                 235                 240 


Val Cys Trp Gly His Val Glu Glu Val Glu Leu Ile Asn Asp Gly Ser 
                245                 250                 255     


Gly Leu Gly Phe Gly Ile Val Gly Gly Lys Thr Ser Gly Val Val Val 
            260                 265                 270         


Arg Thr Ile Val Pro Gly Gly Leu Ala Asp Arg Asp Gly Arg Leu Gln 
        275                 280                 285             


Thr Gly Asp His Ile Leu Lys Ile Gly Gly Thr Asn Val Gln Gly Met 
    290                 295                 300                 


Thr Ser Glu Gln Val Ala Gln Val Leu Arg Asn Cys Gly Asn Ser Val 
305                 310                 315                 320 


Arg Met Leu Val Ala Arg Asp Pro Ala Gly Asp Ile Ser Val Thr Pro 
                325                 330                 335     


Pro Ala Pro Ala Ala Leu Pro Val Ala Leu Pro Thr Val Ala Ser Lys 
            340                 345                 350         


Gly Pro Gly Ser Asp Ser Ser Leu Phe Glu Thr Tyr Asn Val Glu Leu 
        355                 360                 365             


Val Arg Lys Asp Gly Gln Ser Leu Gly Ile Arg Ile Val Gly Tyr Val 
    370                 375                 380                 


Gly Thr Ser His Thr Gly Glu Ala Ser Gly Ile Tyr Val Lys Ser Ile 
385                 390                 395                 400 


Ile Pro Gly Ser Ala Ala Tyr His Asn Gly His Ile Gln Val Asn Asp 
                405                 410                 415     


Lys Ile Val Ala Val Asp Gly Val Asn Ile Gln Gly Phe Ala Asn His 
            420                 425                 430         


Asp Val Val Glu Val Leu Arg Asn Ala Gly Gln Val Val His Leu Thr 
        435                 440                 445             


Leu Val Arg Arg Lys Thr Ser Ser Ser Thr Ser Pro Leu Glu Pro Pro 
    450                 455                 460                 


Ser Asp Arg Gly Thr Val Val Glu Pro Leu Lys Pro Pro Ala Leu Phe 
465                 470                 475                 480 


Leu Thr Gly Ala Val Glu Thr Glu Thr Asn Val Asp Gly Glu Asp Glu 
                485                 490                 495     


Glu Ile Lys Glu Arg Ile Asp Thr Leu Lys Asn Asp Asn Ile Gln Ala 
            500                 505                 510         


Leu Glu Lys Leu Glu Lys Val Pro Asp Ser Pro Glu Asn Glu Leu Lys 
        515                 520                 525             


Ser Arg Trp Glu Asn Leu Leu Gly Pro Asp Tyr Glu Val Met Val Ala 
    530                 535                 540                 


Thr Leu Asp Thr Gln Ile Ala Asp Asp Ala Glu Leu Gln Lys Tyr Ser 
545                 550                 555                 560 


Lys Leu Leu Pro Ile His Thr Leu Arg Leu Gly Val Glu Val Asp Ser 
                565                 570                 575     


Phe Asp Gly His His Tyr Ile Ser Ser Ile Val Ser Gly Gly Pro Val 
            580                 585                 590         


Asp Thr Leu Gly Leu Leu Gln Pro Glu Asp Glu Leu Leu Glu Val Asn 
        595                 600                 605             


Gly Met Gln Leu Tyr Gly Lys Ser Arg Arg Glu Ala Val Ser Phe Leu 
    610                 615                 620                 


Lys Glu Val Pro Pro Pro Phe Thr Leu Val Cys Cys Arg Arg Leu Phe 
625                 630                 635                 640 


Asp Asp Glu Ala Ser Val Asp Glu Pro Arg Arg Thr Glu Thr Ser Leu 
                645                 650                 655     


Pro Glu Thr Glu Val Asp His Asn Met Asp Val Asn Thr Glu Glu Asp 
            660                 665                 670         


Asp Asp Gly Glu Leu Ala Leu Trp Ser Pro Glu Val Lys Ile Val Glu 
        675                 680                 685             


Leu Val Lys Asp Cys Lys Gly Leu Gly Phe Ser Ile Leu Asp Tyr Gln 
    690                 695                 700                 


Asp Pro Leu Asp Pro Thr Arg Ser Val Ile Val Ile Arg Ser Leu Val 
705                 710                 715                 720 


Ala Asp Gly Val Ala Glu Arg Ser Gly Gly Leu Leu Pro Gly Asp Arg 
                725                 730                 735     


Leu Val Ser Val Asn Glu Tyr Cys Leu Asp Asn Thr Ser Leu Ala Glu 
            740                 745                 750         


Ala Val Glu Ile Leu Lys Ala Val Pro Pro Gly Leu Val His Leu Gly 
        755                 760                 765             


Ile Cys Lys Pro Leu Val Glu Asp Asn Glu Glu Glu Ser Cys Tyr Ile 
    770                 775                 780                 


Leu His Ser Ser Ser Asn Glu Asp Lys Thr Glu Phe Ser Gly Thr Ile 
785                 790                 795                 800 


His Asp Ile Asn Ser Ser Leu Ile Leu Glu Ala Pro Lys Gly Phe Arg 
                805                 810                 815     


Asp Glu Pro Tyr Phe Lys Glu Glu Leu Val Asp Glu Pro Phe Leu Asp 
            820                 825                 830         


Leu Gly Lys Ser Phe His Ser Gln Gln Lys Glu Ile Glu Gln Ser Lys 
        835                 840                 845             


Glu Ala Trp Glu Met His Glu Phe Leu Thr Pro Arg Leu Gln Glu Met 
    850                 855                 860                 


Asp Glu Glu Arg Glu Ile Leu Val Asp Glu Glu Tyr Glu Leu Tyr Gln 
865                 870                 875                 880 


Asp Pro Ser Pro Ser Met Glu Leu Tyr Pro Leu Ser His Ile Gln Glu 
                885                 890                 895     


Ala Thr Pro Val Pro Ser Val Asn Glu Leu His Phe Gly Thr Gln Trp 
            900                 905                 910         


Leu His Asp Asn Glu Pro Ser Glu Ser Gln Glu Ala Arg Thr Gly Arg 
        915                 920                 925             


Thr Val Tyr Ser Gln Glu Ala Gln Pro Tyr Gly Tyr Cys Pro Glu Asn 
    930                 935                 940                 


Val Met Lys Glu Asn Phe Val Met Glu Ser Leu Pro Ser Val Pro Ser 
945                 950                 955                 960 


Thr Glu Gly Asn Ser Gln Gln Gly Arg Phe Asp Asp Leu Glu Asn Leu 
                965                 970                 975     


Asn Ser Leu Ala Lys Thr Ser Leu Asp Leu Gly Met Ile Pro Asn Asp 
            980                 985                 990         


Val Gln Gly Pro Ser Leu Leu Ile  Asp Leu Pro Val Val  Ala Gln Arg 
        995                 1000                 1005             


Arg Glu  Gln Glu Asp Leu Pro  Leu Tyr Gln His Gln  Ala Thr Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Ala Ser Ala  Tyr Thr Gly Met Leu  Ser Ser Arg 
    1025                 1030                 1035             


Tyr Ala  Thr Asp Thr Cys Glu  Leu Pro Glu Arg Glu  Glu Gly Glu 
    1040                 1045                 1050             


Gly Glu  Glu Thr Pro Asn Phe  Ser His Trp Gly Pro  Pro Arg Ile 
    1055                 1060                 1065             


Val Glu  Ile Phe Arg Glu Pro  Asn Val Ser Leu Gly  Ile Ser Ile 
    1070                 1075                 1080             


Val Gly  Gly Gln Thr Val Ile  Lys Arg Leu Lys Asn  Gly Glu Glu 
    1085                 1090                 1095             


Leu Lys  Gly Ile Phe Ile Lys  Gln Val Leu Glu Asp  Ser Pro Ala 
    1100                 1105                 1110             


Gly Lys  Thr Asn Ala Leu Lys  Thr Gly Asp Lys Ile  Leu Glu Val 
    1115                 1120                 1125             


Ser Gly  Val Asp Leu Gln Asn  Ala Ser His Ser Glu  Ala Val Glu 
    1130                 1135                 1140             


Ala Ile  Lys Asn Ala Gly Asn  Pro Val Val Phe Ile  Val Gln Ser 
    1145                 1150                 1155             


Leu Ser  Ser Thr Pro Arg Val  Ile Pro Asn Val His  Asn Lys Ala 
    1160                 1165                 1170             


Asn Lys  Ile Thr Gly Asn Gln  Asn Gln Asp Thr Gln  Glu Lys Lys 
    1175                 1180                 1185             


Glu Lys  Arg Gln Gly Thr Ala  Pro Pro Pro Met Lys  Leu Pro Pro 
    1190                 1195                 1200             


Pro Tyr  Lys Ala Leu Thr Asp  Asp Ser Asp Glu Asn  Glu Glu Glu 
    1205                 1210                 1215             


Asp Ala  Phe Thr Asp Gln Lys  Ile Arg Gln Arg Tyr  Ala Asp Leu 
    1220                 1225                 1230             


Pro Gly  Glu Leu His Ile Ile  Glu Leu Glu Lys Asp  Lys Asn Gly 
    1235                 1240                 1245             


Leu Gly  Leu Ser Leu Ala Gly  Asn Lys Asp Arg Ser  Arg Met Ser 
    1250                 1255                 1260             


Ile Phe  Val Val Gly Ile Asn  Pro Glu Gly Pro Ala  Ala Ala Asp 
    1265                 1270                 1275             


Gly Arg  Met Arg Ile Gly Asp  Glu Leu Leu Glu Ile  Asn Asn Gln 
    1280                 1285                 1290             


Ile Leu  Tyr Gly Arg Ser His  Gln Asn Ala Ser Ala  Ile Ile Lys 
    1295                 1300                 1305             


Thr Ala  Pro Ser Lys Val Lys  Leu Val Phe Ile Arg  Asn Glu Asp 
    1310                 1315                 1320             


Ala Val  Asn Gln Met Ala Val  Thr Pro Phe Pro Val  Pro Ser Ser 
    1325                 1330                 1335             


Ser Pro  Ser Ser Ile Glu Asp  Gln Ser Gly Thr Glu  Pro Ile Ser 
    1340                 1345                 1350             


Ser Glu  Glu Asp Gly Ser Val  Glu Val Gly Ile Lys  Gln Leu Pro 
    1355                 1360                 1365             


Glu Ser  Glu Ser Phe Lys Leu  Ala Val Ser Gln Met  Lys Gln Gln 
    1370                 1375                 1380             


Lys Tyr  Pro Thr Lys Val Ser  Phe Ser Ser Gln Glu  Ile Pro Leu 
    1385                 1390                 1395             


Ala Pro  Ala Ser Ser Tyr His  Ser Thr Asp Ala Asp  Phe Thr Gly 
    1400                 1405                 1410             


Tyr Gly  Gly Phe Gln Ala Pro  Leu Ser Val Asp Pro  Ala Thr Cys 
    1415                 1420                 1425             


Pro Ile  Val Pro Gly Gln Glu  Met Ile Ile Glu Ile  Ser Lys Gly 
    1430                 1435                 1440             


Arg Ser  Gly Leu Gly Leu Ser  Ile Val Gly Gly Lys  Asp Thr Pro 
    1445                 1450                 1455             


Leu Asn  Ala Ile Val Ile His  Glu Val Tyr Glu Glu  Gly Ala Ala 
    1460                 1465                 1470             


Ala Arg  Asp Gly Arg Leu Trp  Ala Gly Asp Gln Ile  Leu Glu Val 
    1475                 1480                 1485             


Asn Gly  Val Asp Leu Arg Asn  Ser Ser His Glu Glu  Ala Ile Thr 
    1490                 1495                 1500             


Ala Leu  Arg Gln Thr Pro Gln  Lys Val Arg Leu Val  Val Tyr Arg 
    1505                 1510                 1515             


Asp Glu  Ala His Tyr Arg Asp  Glu Glu Asn Leu Glu  Ile Phe Pro 
    1520                 1525                 1530             


Val Asp  Leu Gln Lys Lys Ala  Gly Arg Gly Leu Gly  Leu Ser Ile 
    1535                 1540                 1545             


Val Gly  Lys Arg Asn Gly Ser  Gly Val Phe Ile Ser  Asp Ile Val 
    1550                 1555                 1560             


Lys Gly  Gly Ala Ala Asp Leu  Asp Gly Arg Leu Ile  Gln Gly Asp 
    1565                 1570                 1575             


Gln Ile  Leu Ser Val Asn Gly  Glu Asp Met Arg Asn  Ala Ser Gln 
    1580                 1585                 1590             


Glu Thr  Val Ala Thr Ile Leu  Lys Cys Ala Gln Gly  Leu Val Gln 
    1595                 1600                 1605             


Leu Glu  Ile Gly Arg Leu Arg  Ala Gly Ser Trp Thr  Ser Ala Arg 
    1610                 1615                 1620             


Thr Thr  Ser Gln Asn Ser Gln  Gly Ser Gln Gln Ser  Ala His Ser 
    1625                 1630                 1635             


Ser Cys  His Pro Ser Phe Ala  Pro Val Ile Thr Gly  Leu Gln Asn 
    1640                 1645                 1650             


Leu Val  Gly Thr Lys Arg Val  Ser Asp Pro Ser Gln  Lys Asn Ser 
    1655                 1660                 1665             


Gly Thr  Asp Met Glu Pro Arg  Thr Val Glu Ile Asn  Arg Glu Leu 
    1670                 1675                 1680             


Ser Asp  Ala Leu Gly Ile Ser  Ile Ala Gly Gly Arg  Gly Ser Pro 
    1685                 1690                 1695             


Leu Gly  Asp Ile Pro Val Phe  Ile Ala Met Ile Gln  Ala Ser Gly 
    1700                 1705                 1710             


Val Ala  Ala Arg Thr Gln Lys  Leu Lys Val Gly Asp  Arg Ile Val 
    1715                 1720                 1725             


Ser Ile  Asn Gly Gln Pro Leu  Asp Gly Leu Ser His  Ala Asp Val 
    1730                 1735                 1740             


Val Asn  Leu Leu Lys Asn Ala  Tyr Gly Arg Ile Ile  Leu Gln Val 
    1745                 1750                 1755             


Val Ala  Asp Thr Asn Ile Ser  Ala Ile Ala Ala Gln  Leu Glu Asn 
    1760                 1765                 1770             


Met Ser  Thr Gly Tyr His Leu  Gly Ser Pro Thr Ala  Glu His His 
    1775                 1780                 1785             


Pro Glu  Asp Thr Glu Glu Gln  Leu Gln Met Thr Ala  Asp 
    1790                 1795                 1800     


<210>  235
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Pro Tyr Asn Phe Cys Leu Pro Ser Leu Ser Cys Arg Thr Ser Cys 
1               5                   10                  15      


Ser Ser Arg Pro Cys Val Pro Pro Ser Cys His Ser Cys Thr Leu Pro 
            20                  25                  30          


Gly Ala Cys Asn Ile Pro Ala Asn Val Ser Asn Cys Asn Trp Phe Cys 
        35                  40                  45              


Glu Gly Ser Phe Asn Gly Ser Glu Lys Glu Thr Met Gln Phe Leu Asn 
    50                  55                  60                  


Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Gln Leu Glu Arg Asp 
65                  70                  75                  80  


Asn Ala Glu Leu Glu Asn Leu Ile Arg Glu Arg Ser Gln Gln Gln Glu 
                85                  90                  95      


Pro Leu Leu Cys Pro Ser Tyr Gln Ser Tyr Phe Lys Thr Ile Glu Glu 
            100                 105                 110         


Leu Gln Gln Lys Ile Leu Cys Thr Lys Ser Glu Asn Ala Arg Leu Val 
        115                 120                 125             


Val Gln Ile Asp Asn Ala Lys Leu Ala Ala Asp Asp Phe Arg Thr Lys 
    130                 135                 140                 


Tyr Gln Thr Glu Leu Ser Leu Arg Gln Leu Val Glu Ser Asp Ile Asn 
145                 150                 155                 160 


Gly Leu Arg Arg Ile Leu Asp Glu Leu Thr Leu Cys Lys Ser Asp Leu 
                165                 170                 175     


Glu Ala Gln Val Glu Ser Leu Lys Glu Glu Leu Leu Cys Leu Lys Ser 
            180                 185                 190         


Asn His Glu Gln Glu Val Asn Thr Leu Arg Cys Gln Leu Gly Asp Arg 
        195                 200                 205             


Leu Asn Val Glu Val Asp Ala Ala Pro Thr Val Asp Leu Asn Arg Val 
    210                 215                 220                 


Leu Asn Glu Thr Arg Ser Gln Tyr Glu Ala Leu Val Glu Thr Asn Arg 
225                 230                 235                 240 


Arg Glu Val Glu Gln Trp Phe Thr Thr Gln Thr Glu Glu Leu Asn Lys 
                245                 250                 255     


Gln Val Val Ser Ser Ser Glu Gln Leu Gln Ser Tyr Gln Ala Glu Ile 
            260                 265                 270         


Ile Glu Leu Arg Arg Thr Val Asn Ala Leu Glu Ile Glu Leu Gln Ala 
        275                 280                 285             


Gln His Asn Leu Arg Asp Ser Leu Glu Asn Thr Leu Thr Glu Ser Glu 
    290                 295                 300                 


Ala Arg Tyr Ser Ser Gln Leu Ser Gln Val Gln Ser Leu Ile Thr Asn 
305                 310                 315                 320 


Val Glu Ser Gln Leu Ala Glu Ile Arg Ser Asp Leu Glu Arg Gln Asn 
                325                 330                 335     


Gln Glu Tyr Gln Val Leu Leu Asp Val Arg Ala Arg Leu Glu Cys Glu 
            340                 345                 350         


Ile Asn Thr Tyr Arg Ser Leu Leu Glu Ser Glu Asp Cys Asn Leu Pro 
        355                 360                 365             


Ser Asn Pro Cys Ala Thr Thr Asn Ala Cys Ser Lys Pro Ile Gly Pro 
    370                 375                 380                 


Cys Leu Ser Asn Pro Cys Thr Ser Cys Val Pro Pro Ala Pro Cys Thr 
385                 390                 395                 400 


Pro Cys Ala Pro Arg Pro Arg Cys Gly Pro Cys Asn Ser Phe Val Arg 
                405                 410                 415     


<210>  236
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Thr Ser Ser Cys Cys Val Thr Asn Asn Leu Gln Ala Ser Leu Lys 
1               5                   10                  15      


Ser Cys Pro Arg Pro Ala Ser Val Cys Ser Ser Gly Val Asn Cys Arg 
            20                  25                  30          


Pro Glu Leu Cys Leu Gly Tyr Val Cys Gln Pro Met Ala Cys Leu Pro 
        35                  40                  45              


Ser Val Cys Leu Pro Thr Thr Phe Arg Pro Ala Ser Cys Leu Ser Lys 
    50                  55                  60                  


Thr Tyr Leu Ser Ser Ser Cys Gln Ala Ala Ser Gly Ile Ser Gly Ser 
65                  70                  75                  80  


Met Gly Pro Gly Ser Trp Tyr Ser Glu Gly Ala Phe Asn Gly Asn Glu 
                85                  90                  95      


Lys Glu Thr Met Gln Phe Leu Asn Asp Arg Leu Ala Ser Tyr Leu Thr 
            100                 105                 110         


Arg Val Arg Gln Leu Glu Gln Glu Asn Ala Glu Leu Glu Ser Arg Ile 
        115                 120                 125             


Gln Glu Ala Ser His Ser Gln Val Leu Thr Met Thr Pro Asp Tyr Gln 
    130                 135                 140                 


Ser His Phe Arg Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr 
145                 150                 155                 160 


Lys Ala Glu Asn Ala Arg Met Val Val Asn Ile Asp Asn Ala Lys Leu 
                165                 170                 175     


Ala Ala Asp Asp Phe Arg Ala Lys Tyr Glu Ala Glu Leu Ala Met Arg 
            180                 185                 190         


Gln Leu Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Ile Leu Asp Asp 
        195                 200                 205             


Leu Thr Leu Cys Lys Ala Asp Leu Glu Ala Gln Val Glu Ser Leu Lys 
    210                 215                 220                 


Glu Glu Leu Met Cys Leu Lys Lys Asn His Glu Glu Glu Val Gly Ser 
225                 230                 235                 240 


Leu Arg Cys Gln Leu Gly Asp Arg Leu Asn Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Pro Pro Val Asp Leu Thr Arg Val Leu Glu Glu Met Arg Cys Gln Tyr 
            260                 265                 270         


Glu Ala Met Val Glu Ala Asn Arg Arg Asp Val Glu Glu Trp Phe Asn 
        275                 280                 285             


Met Gln Met Glu Glu Leu Asn Gln Gln Val Ala Thr Ser Ser Glu Gln 
    290                 295                 300                 


Leu Gln Asn Tyr Gln Ser Asp Ile Ile Asp Leu Arg Arg Thr Val Asn 
305                 310                 315                 320 


Thr Leu Glu Ile Glu Leu Gln Ala Gln His Ser Leu Arg Asp Ser Leu 
                325                 330                 335     


Glu Asn Thr Leu Thr Glu Ser Glu Ala Arg Tyr Ser Ser Gln Leu Ala 
            340                 345                 350         


Gln Met Gln Cys Met Ile Thr Asn Val Glu Ala Gln Leu Ala Glu Ile 
        355                 360                 365             


Arg Ala Asp Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu Asp 
    370                 375                 380                 


Val Arg Ala Arg Leu Glu Gly Glu Ile Asn Thr Tyr Arg Ser Leu Leu 
385                 390                 395                 400 


Glu Asn Glu Asp Cys Lys Leu Pro Cys Asn Pro Cys Ser Thr Pro Ser 
                405                 410                 415     


Cys Thr Thr Cys Val Pro Ser Pro Cys Val Pro Arg Thr Val Cys Val 
            420                 425                 430         


Pro Arg Thr Val Gly Met Pro Cys Ser Pro Cys Pro Gln Gly Arg Tyr 
        435                 440                 445             


<210>  237
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ala Thr Gln Thr Cys Thr Pro Thr Phe Ser Thr Gly Ser Ile Lys 
1               5                   10                  15      


Gly Leu Cys Gly Thr Ala Gly Gly Ile Ser Arg Val Ser Ser Ile Arg 
            20                  25                  30          


Ser Val Gly Ser Cys Arg Val Pro Ser Leu Ala Gly Ala Ala Gly Tyr 
        35                  40                  45              


Ile Ser Ser Ala Arg Ser Gly Leu Ser Gly Leu Gly Ser Cys Leu Pro 
    50                  55                  60                  


Gly Ser Tyr Leu Ser Ser Glu Cys His Thr Ser Gly Phe Val Gly Ser 
65                  70                  75                  80  


Gly Gly Trp Phe Cys Glu Gly Ser Phe Asn Gly Ser Glu Lys Glu Thr 
                85                  90                  95      


Met Gln Phe Leu Asn Asp Arg Leu Ala Asn Tyr Leu Glu Lys Val Arg 
            100                 105                 110         


Gln Leu Glu Arg Glu Asn Ala Glu Leu Glu Ser Arg Ile Gln Glu Trp 
        115                 120                 125             


Tyr Glu Phe Gln Ile Pro Tyr Ile Cys Pro Asp Tyr Gln Ser Tyr Phe 
    130                 135                 140                 


Lys Thr Ile Glu Asp Phe Gln Gln Lys Ile Leu Leu Thr Lys Ser Glu 
145                 150                 155                 160 


Asn Ala Arg Leu Val Leu Gln Ile Asp Asn Ala Lys Leu Ala Ala Asp 
                165                 170                 175     


Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu Ser Leu Arg Gln Leu Val 
            180                 185                 190         


Glu Ala Asp Ile Asn Gly Leu Arg Arg Ile Leu Asp Glu Leu Thr Leu 
        195                 200                 205             


Cys Lys Ala Asp Leu Glu Ala Gln Val Glu Ser Leu Lys Glu Glu Leu 
    210                 215                 220                 


Met Cys Leu Lys Lys Asn His Glu Glu Glu Val Ser Val Leu Arg Cys 
225                 230                 235                 240 


Gln Leu Gly Asp Arg Leu Asn Val Glu Val Asp Ala Ala Pro Pro Val 
                245                 250                 255     


Asp Leu Asn Lys Ile Leu Glu Asp Met Arg Cys Gln Tyr Glu Ala Leu 
            260                 265                 270         


Val Glu Asn Asn Arg Arg Asp Val Glu Ala Trp Phe Asn Thr Gln Thr 
        275                 280                 285             


Glu Glu Leu Asn Gln Gln Val Val Ser Ser Ser Glu Gln Leu Gln Cys 
    290                 295                 300                 


Cys Gln Thr Glu Ile Ile Glu Leu Arg Arg Thr Val Asn Ala Leu Glu 
305                 310                 315                 320 


Ile Glu Leu Gln Ala Gln His Ser Met Arg Asn Ser Leu Glu Ser Thr 
                325                 330                 335     


Leu Ala Glu Thr Glu Ala Arg Tyr Ser Ser Gln Leu Ala Gln Met Gln 
            340                 345                 350         


Cys Leu Ile Ser Asn Val Glu Ala Gln Leu Ser Glu Ile Arg Cys Asp 
        355                 360                 365             


Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu Asp Val Lys Ala 
    370                 375                 380                 


Arg Leu Glu Gly Glu Ile Ala Thr Tyr Arg His Leu Leu Glu Gly Glu 
385                 390                 395                 400 


Asp Cys Lys Leu Pro Pro Gln Pro Cys Ala Thr Ala Cys Lys Pro Val 
                405                 410                 415     


Ile Arg Val Pro Ser Val Pro Pro Val Pro Cys Val Pro Ser Val Pro 
            420                 425                 430         


Cys Thr Pro Ala Pro Gln Val Gly Thr Gln Ile Arg Thr Ile Thr Glu 
        435                 440                 445             


Glu Ile Arg Asp Gly Lys Val Ile Ser Ser Arg Glu His Val Gln Ser 
    450                 455                 460                 


Arg Pro Leu 
465         


<210>  238
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ile Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Tyr 
            580                 


<210>  239
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Ser Arg Phe Ser Ser Gly Gly Ala Cys Gly 
    50                  55                  60                  


Leu Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Ser Phe 
65                  70                  75                  80  


Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Leu 
                85                  90                  95      


Gly Gly Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu Leu Val 
            100                 105                 110         


Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
        115                 120                 125             


Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
    130                 135                 140                 


Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ala Glu Ile Lys 
145                 150                 155                 160 


Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn Lys Ile 
                165                 170                 175     


Leu Thr Ala Thr Val Asp Asn Ala Asn Val Leu Leu Gln Ile Asp Asn 
            180                 185                 190         


Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu 
        195                 200                 205             


Asn Leu Arg Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val 
    210                 215                 220                 


Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile Glu 
225                 230                 235                 240 


Ser Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu 
                245                 250                 255     


Met Asn Ala Leu Arg Gly Gln Val Gly Gly Asp Val Asn Val Glu Met 
            260                 265                 270         


Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met Arg 
        275                 280                 285             


Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu 
    290                 295                 300                 


Trp Phe Phe Thr Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr Asn 
305                 310                 315                 320 


Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg 
                325                 330                 335     


Thr Met Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys 
            340                 345                 350         


Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met 
        355                 360                 365             


Gln Leu Ala Gln Ile Gln Glu Met Ile Gly Ser Val Glu Glu Gln Leu 
    370                 375                 380                 


Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile 
385                 390                 395                 400 


Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg 
                405                 410                 415     


Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Ser Gln Phe Ser 
            420                 425                 430         


Ser Gly Ser Gln Ser Ser Arg Asp Val Thr Ser Ser Ser Arg Gln Ile 
        435                 440                 445             


Arg Thr Lys Val Met Asp Val His Asp Gly Lys Val Val Ser Thr His 
    450                 455                 460                 


Glu Gln Val Leu Arg Thr Lys Asn 
465                 470         


<210>  240
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Arg Phe Ser Ser Gly Gly Ala Cys Gly Leu 
    50                  55                  60                  


Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Phe Gly Ser 
65                  70                  75                  80  


Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Phe Gly Gly 
                85                  90                  95      


Gly Leu Gly Ala Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu 
            100                 105                 110         


Leu Val Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu 
        115                 120                 125             


Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp 
    130                 135                 140                 


Leu Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ser Glu 
145                 150                 155                 160 


Ile Lys Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn 
                165                 170                 175     


Lys Ile Ile Ala Ala Thr Ile Glu Asn Ala Gln Pro Ile Leu Gln Ile 
            180                 185                 190         


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu His 
        195                 200                 205             


Glu Leu Ala Leu Arg Gln Thr Val Glu Ala Asp Val Asn Gly Leu Arg 
    210                 215                 220                 


Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln 
225                 230                 235                 240 


Ile Glu Gly Leu Lys Glu Glu Leu Ala Tyr Leu Arg Lys Asn His Glu 
                245                 250                 255     


Glu Glu Met Leu Ala Leu Arg Gly Gln Thr Gly Gly Asp Val Asn Val 
            260                 265                 270         


Glu Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu 
        275                 280                 285             


Met Arg Asp Gln Tyr Glu Gln Met Ala Glu Lys Asn Arg Arg Asp Ala 
    290                 295                 300                 


Glu Thr Trp Phe Leu Ser Lys Thr Glu Glu Leu Asn Lys Glu Val Ala 
305                 310                 315                 320 


Ser Asn Ser Glu Leu Val Gln Ser Ser Arg Ser Glu Val Thr Glu Leu 
                325                 330                 335     


Arg Arg Val Leu Gln Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser 
            340                 345                 350         


Met Lys Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr 
        355                 360                 365             


Cys Met Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu Glu 
    370                 375                 380                 


Gln Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Ser Gln Glu Tyr 
385                 390                 395                 400 


Gln Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr 
                405                 410                 415     


Tyr Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Gln Gln 
            420                 425                 430         


Ala Ser Gly Gln Ser Tyr Ser Ser Arg Glu Val Phe Thr Ser Ser Ser 
        435                 440                 445             


Ser Ser Ser Ser Arg Gln Thr Arg Pro Ile Leu Lys Glu Gln Ser Ser 
    450                 455                 460                 


Ser Ser Phe Ser Gln Gly Gln Ser Ser 
465                 470             


<210>  241
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ser Phe Thr Thr Arg Ser Thr Phe Ser Thr Asn Tyr Arg Ser Leu 
1               5                   10                  15      


Gly Ser Val Gln Ala Pro Ser Tyr Gly Ala Arg Pro Val Ser Ser Ala 
            20                  25                  30          


Ala Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Arg Ile Ser Val 
        35                  40                  45              


Ser Arg Ser Thr Ser Phe Arg Gly Gly Met Gly Ser Gly Gly Leu Ala 
    50                  55                  60                  


Thr Gly Ile Ala Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Glu 
65                  70                  75                  80  


Lys Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 
                85                  90                  95      


Arg Val Arg Ser Leu Glu Thr Glu Asn Arg Arg Leu Glu Ser Lys Ile 
            100                 105                 110         


Arg Glu His Leu Glu Lys Lys Gly Pro Gln Val Arg Asp Trp Ser His 
        115                 120                 125             


Tyr Phe Lys Ile Ile Glu Asp Leu Arg Ala Gln Ile Phe Ala Asn Thr 
    130                 135                 140                 


Val Asp Asn Ala Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu Ala 
145                 150                 155                 160 


Ala Asp Asp Phe Arg Val Lys Tyr Glu Thr Glu Leu Ala Met Arg Gln 
                165                 170                 175     


Ser Val Glu Asn Asp Ile His Gly Leu Arg Lys Val Ile Asp Asp Thr 
            180                 185                 190         


Asn Ile Thr Arg Leu Gln Leu Glu Thr Glu Ile Glu Ala Leu Lys Glu 
        195                 200                 205             


Glu Leu Leu Phe Met Lys Lys Asn His Glu Glu Glu Val Lys Gly Leu 
    210                 215                 220                 


Gln Ala Gln Ile Ala Ser Ser Gly Leu Thr Val Glu Val Asp Ala Pro 
225                 230                 235                 240 


Lys Ser Gln Asp Leu Ala Lys Ile Met Ala Asp Ile Arg Ala Gln Tyr 
                245                 250                 255     


Asp Glu Leu Ala Arg Lys Asn Arg Glu Glu Leu Asp Lys Tyr Trp Ser 
            260                 265                 270         


Gln Gln Ile Glu Glu Ser Thr Thr Val Val Thr Thr Gln Ser Ala Glu 
        275                 280                 285             


Val Gly Ala Ala Glu Thr Thr Leu Thr Glu Leu Arg Arg Thr Val Gln 
    290                 295                 300                 


Ser Leu Glu Ile Asp Leu Asp Ser Met Arg Asn Leu Lys Ala Ser Leu 
305                 310                 315                 320 


Glu Asn Ser Leu Arg Glu Val Glu Ala Arg Tyr Ala Leu Gln Met Glu 
                325                 330                 335     


Gln Leu Asn Gly Ile Leu Leu His Leu Glu Ser Glu Leu Ala Gln Thr 
            340                 345                 350         


Arg Ala Glu Gly Gln Arg Gln Ala Gln Glu Tyr Glu Ala Leu Leu Asn 
        355                 360                 365             


Ile Lys Val Lys Leu Glu Ala Glu Ile Ala Thr Tyr Arg Arg Leu Leu 
    370                 375                 380                 


Glu Asp Gly Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp Ser Ser Asn 
385                 390                 395                 400 


Ser Met Gln Thr Ile Gln Lys Thr Thr Thr Arg Arg Ile Val Asp Gly 
                405                 410                 415     


Lys Val Val Ser Glu Thr Asn Asp Thr Lys Val Leu Arg His 
            420                 425                 430 


<210>  242
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly 
1               5                   10                  15      


Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg 
            20                  25                  30          


Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser 
        35                  40                  45              


Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Gly Ala Tyr Gly Gly Gly 
    50                  55                  60                  


Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu 
65                  70                  75                  80  


Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 
                85                  90                  95      


Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile 
            100                 105                 110         


Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala 
    130                 135                 140                 


Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu 
145                 150                 155                 160 


Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg 
                165                 170                 175     


Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu 
            180                 185                 190         


Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys 
        195                 200                 205             


Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr 
    210                 215                 220                 


Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala 
225                 230                 235                 240 


Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr 
                245                 250                 255     


Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr 
            260                 265                 270         


Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln 
        275                 280                 285             


Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln 
    290                 295                 300                 


Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu 
305                 310                 315                 320 


Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala 
                325                 330                 335     


His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Gly Asp Val 
            340                 345                 350         


Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp 
        355                 360                 365             


Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu 
    370                 375                 380                 


Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu 
385                 390                 395                 400 


<210>  243
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ser Cys Arg Gln Phe Ser Ser Ser Tyr Leu Ser Arg Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Leu Gly Ser Gly Gly Ser Ile Arg Ser Ser Tyr 
            20                  25                  30          


Ser Arg Phe Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Arg Phe Ser 
        35                  40                  45              


Ser Ser Ser Gly Tyr Gly Gly Gly Ser Ser Arg Val Cys Gly Arg Gly 
    50                  55                  60                  


Gly Gly Gly Ser Phe Gly Tyr Ser Tyr Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Phe Ser Ala Ser Ser Leu Gly Gly Gly Phe Gly Gly Gly Ser Arg Gly 
                85                  90                  95      


Phe Gly Gly Ala Ser Gly Gly Gly Tyr Ser Ser Ser Gly Gly Phe Gly 
            100                 105                 110         


Gly Gly Phe Gly Gly Gly Ser Gly Gly Gly Phe Gly Gly Gly Tyr Gly 
        115                 120                 125             


Ser Gly Phe Gly Gly Phe Gly Gly Phe Gly Gly Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asp Gly Gly Ile Leu Thr Ala Asn Glu Lys Ser Thr Met Gln Glu Leu 
145                 150                 155                 160 


Asn Ser Arg Leu Ala Ser Tyr Leu Asp Lys Val Gln Ala Leu Glu Glu 
                165                 170                 175     


Ala Asn Asn Asp Leu Glu Asn Lys Ile Gln Asp Trp Tyr Asp Lys Lys 
            180                 185                 190         


Gly Pro Ala Ala Ile Gln Lys Asn Tyr Ser Pro Tyr Tyr Asn Thr Ile 
        195                 200                 205             


Asp Asp Leu Lys Asp Gln Ile Val Asp Leu Thr Val Gly Asn Asn Lys 
    210                 215                 220                 


Thr Leu Leu Asp Ile Asp Asn Thr Arg Met Thr Leu Asp Asp Phe Arg 
225                 230                 235                 240 


Ile Lys Phe Glu Met Glu Gln Asn Leu Arg Gln Gly Val Asp Ala Asp 
                245                 250                 255     


Ile Asn Gly Leu Arg Gln Val Leu Asp Asn Leu Thr Met Glu Lys Ser 
            260                 265                 270         


Asp Leu Glu Met Gln Tyr Glu Thr Leu Gln Glu Glu Leu Met Ala Leu 
        275                 280                 285             


Lys Lys Asn His Lys Glu Glu Met Ser Gln Leu Thr Gly Gln Asn Ser 
    290                 295                 300                 


Gly Asp Val Asn Val Glu Ile Asn Val Ala Pro Gly Lys Asp Leu Thr 
305                 310                 315                 320 


Lys Thr Leu Asn Asp Met Arg Gln Glu Tyr Glu Gln Leu Ile Ala Lys 
                325                 330                 335     


Asn Arg Lys Asp Ile Glu Asn Gln Tyr Glu Thr Gln Ile Thr Gln Ile 
            340                 345                 350         


Glu His Glu Val Ser Ser Ser Gly Gln Glu Val Gln Ser Ser Ala Lys 
        355                 360                 365             


Glu Val Thr Gln Leu Arg His Gly Val Gln Glu Leu Glu Ile Glu Leu 
    370                 375                 380                 


Gln Ser Gln Leu Ser Lys Lys Ala Ala Leu Glu Lys Ser Leu Glu Asp 
385                 390                 395                 400 


Thr Lys Asn Arg Tyr Cys Gly Gln Leu Gln Met Ile Gln Glu Gln Ile 
                405                 410                 415     


Ser Asn Leu Glu Ala Gln Ile Thr Asp Val Arg Gln Glu Ile Glu Cys 
            420                 425                 430         


Gln Asn Gln Glu Tyr Ser Leu Leu Leu Ser Ile Lys Met Arg Leu Glu 
        435                 440                 445             


Lys Glu Ile Glu Thr Tyr His Asn Leu Leu Glu Gly Gly Gln Glu Asp 
    450                 455                 460                 


Phe Glu Ser Ser Gly Ala Gly Lys Ile Gly Leu Gly Gly Arg Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Tyr Gly Arg Gly Ser Arg Gly Gly Ser Gly Gly Ser 
                485                 490                 495     


Tyr Gly Gly Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Ser 
            500                 505                 510         


Arg Gly Gly Ser Gly Gly Ser Tyr Gly Gly Gly Ser Gly Ser Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Gly Gly His Ser Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly His Ser Gly Gly Ser Gly Gly Asn Tyr Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Ser Gly Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser 
                565                 570                 575     


Gly Ser Arg Gly Gly Ser Gly Gly Ser His Gly Gly Gly Ser Gly Phe 
            580                 585                 590         


Gly Gly Glu Ser Gly Gly Ser Tyr Gly Gly Gly Glu Glu Ala Ser Gly 
        595                 600                 605             


Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Lys Ser Ser His Ser 
    610                 615                 620             


<210>  244
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Thr Cys Gly Ser Gly Phe Gly Gly Arg Ala Phe Ser Cys Ile Ser 
1               5                   10                  15      


Ala Cys Gly Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr 
            20                  25                  30          


Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His 
        35                  40                  45              


Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly 
    50                  55                  60                  


Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr 
65                  70                  75                  80  


Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp 
                85                  90                  95      


Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser 
            100                 105                 110         


Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu 
        115                 120                 125             


Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg 
    130                 135                 140                 


Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu 
                165                 170                 175     


Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys 
            180                 185                 190         


Lys Tyr Glu Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe 
        195                 200                 205             


Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp 
    210                 215                 220                 


Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg 
225                 230                 235                 240 


Arg Leu Tyr Glu Glu Glu Ile Leu Ile Leu Gln Ser His Ile Ser Asp 
                245                 250                 255     


Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp 
            260                 265                 270         


Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg 
        275                 280                 285             


Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met 
    290                 295                 300                 


Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu 
305                 310                 315                 320 


Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val 
                325                 330                 335     


Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln 
            340                 345                 350         


Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu 
        355                 360                 365             


Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys 
    370                 375                 380                 


Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp 
385                 390                 395                 400 


Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg 
                405                 410                 415     


Leu Cys Glu Gly Ile Gly Ala Val Asn Val Cys Val Ser Ser Ser Arg 
            420                 425                 430         


Gly Gly Val Val Cys Gly Asp Leu Cys Val Ser Gly Ser Arg Pro Val 
        435                 440                 445             


Thr Gly Ser Val Cys Ser Ala Pro Cys Asn Gly Asn Val Ala Val Ser 
    450                 455                 460                 


Thr Gly Leu Cys Ala Pro Cys Gly Gln Leu Asn Thr Thr Cys Gly Gly 
465                 470                 475                 480 


Gly Ser Cys Gly Val Gly Ser Cys Gly Ile Ser Ser Leu Gly Val Gly 
                485                 490                 495     


Ser Cys Gly Ser Ser Cys Arg Lys Cys 
            500                 505 


<210>  245
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ser Cys Arg Ser Tyr Arg Ile Ser Ser Gly Cys Gly Val Thr Arg 
1               5                   10                  15      


Asn Phe Ser Ser Cys Ser Ala Val Ala Pro Lys Thr Gly Asn Arg Cys 
            20                  25                  30          


Cys Ile Ser Ala Ala Pro Tyr Arg Gly Val Ser Cys Tyr Arg Gly Leu 
        35                  40                  45              


Thr Gly Phe Gly Ser Arg Ser Leu Cys Asn Leu Gly Ser Cys Gly Pro 
    50                  55                  60                  


Arg Ile Ala Val Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe 
65                  70                  75                  80  


Gly Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr 
                85                  90                  95      


Thr Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile 
            100                 105                 110         


Asp Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys 
        115                 120                 125             


Ser Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu 
    130                 135                 140                 


Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Trp Gln Phe Tyr Gln Asn 
145                 150                 155                 160 


Gln Arg Cys Cys Glu Ser Asn Leu Glu Pro Leu Phe Ser Gly Tyr Ile 
                165                 170                 175     


Glu Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg 
            180                 185                 190         


Leu Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys 
        195                 200                 205             


Lys Lys Tyr Glu Glu Glu Val Ala Leu Arg Ala Thr Ala Glu Asn Glu 
    210                 215                 220                 


Phe Val Val Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser 
225                 230                 235                 240 


Asp Leu Glu Ala Asn Val Glu Ala Leu Val Glu Glu Ser Ser Phe Leu 
                245                 250                 255     


Arg Arg Leu Tyr Glu Glu Glu Ile Arg Val Leu Gln Ala His Ile Ser 
            260                 265                 270         


Asp Thr Ser Val Ile Val Lys Met Asp Asn Ser Arg Asp Leu Asn Met 
        275                 280                 285             


Asp Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Val Ala Ser 
    290                 295                 300                 


Arg Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu 
305                 310                 315                 320 


Met Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys 
                325                 330                 335     


Glu Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu 
            340                 345                 350         


Ile Glu Asn Ala Lys Cys Gln Arg Ala Lys Leu Glu Ala Ala Val Ala 
        355                 360                 365             


Glu Ala Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys 
    370                 375                 380                 


Leu Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala 
385                 390                 395                 400 


Cys Leu Leu Lys Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu 
                405                 410                 415     


Asp Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu His 
            420                 425                 430         


Arg Leu Cys Glu Gly Val Gly Ser Val Asn Val Cys Val Ser Ser Ser 
        435                 440                 445             


Arg Gly Gly Val Ser Cys Gly Gly Leu Ser Tyr Ser Thr Thr Pro Gly 
    450                 455                 460                 


Arg Gln Ile Thr Ser Gly Pro Ser Ala Ile Gly Gly Ser Ile Thr Val 
465                 470                 475                 480 


Val Ala Pro Asp Ser Cys Ala Pro Cys Gln Pro Arg Ser Ser Ser Phe 
                485                 490                 495     


Ser Cys Gly Ser Ser Arg Ser Val Arg Phe Ala 
            500                 505         


<210>  246
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ser Arg Gln Phe Ser Ser Arg Ser Gly Tyr Arg Ser Gly Gly Gly 
1               5                   10                  15      


Phe Ser Ser Gly Ser Ala Gly Ile Ile Asn Tyr Gln Arg Arg Thr Thr 
            20                  25                  30          


Ser Ser Ser Thr Arg Arg Ser Gly Gly Gly Gly Gly Arg Phe Ser Ser 
        35                  40                  45              


Cys Gly Gly Gly Gly Gly Ser Phe Gly Ala Gly Gly Gly Phe Gly Ser 
    50                  55                  60                  


Arg Ser Leu Val Asn Leu Gly Gly Ser Lys Ser Ile Ser Ile Ser Val 
65                  70                  75                  80  


Ala Arg Gly Gly Gly Arg Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly 
                85                  90                  95      


Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly 
            100                 105                 110         


Gly Ile Gly Gly Gly Gly Phe Gly Gly Phe Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Tyr Gly Gly Gly Tyr Gly 
    130                 135                 140                 


Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Ser 
145                 150                 155                 160 


Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Glu Ile Gln Lys Val 
                165                 170                 175     


Lys Ser Arg Glu Arg Glu Gln Ile Lys Ser Leu Asn Asn Gln Phe Ala 
            180                 185                 190         


Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu 
        195                 200                 205             


Gln Thr Lys Trp Glu Leu Leu Gln Gln Val Asp Thr Ser Thr Arg Thr 
    210                 215                 220                 


His Asn Leu Glu Pro Tyr Phe Glu Ser Phe Ile Asn Asn Leu Arg Arg 
225                 230                 235                 240 


Arg Val Asp Gln Leu Lys Ser Asp Gln Ser Arg Leu Asp Ser Glu Leu 
                245                 250                 255     


Lys Asn Met Gln Asp Met Val Glu Asp Tyr Arg Asn Lys Tyr Glu Asp 
            260                 265                 270         


Glu Ile Asn Lys Arg Thr Asn Ala Glu Asn Glu Phe Val Thr Ile Lys 
        275                 280                 285             


Lys Asp Val Asp Gly Ala Tyr Met Thr Lys Val Asp Leu Gln Ala Lys 
    290                 295                 300                 


Leu Asp Asn Leu Gln Gln Glu Ile Asp Phe Leu Thr Ala Leu Tyr Gln 
305                 310                 315                 320 


Ala Glu Leu Ser Gln Met Gln Thr Gln Ile Ser Glu Thr Asn Val Ile 
                325                 330                 335     


Leu Ser Met Asp Asn Asn Arg Ser Leu Asp Leu Asp Ser Ile Ile Ala 
            340                 345                 350         


Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Gln Lys Ser Lys Ala Glu 
        355                 360                 365             


Ala Glu Ser Leu Tyr Gln Ser Lys Tyr Glu Glu Leu Gln Ile Thr Ala 
    370                 375                 380                 


Gly Arg His Gly Asp Ser Val Arg Asn Ser Lys Ile Glu Ile Ser Glu 
385                 390                 395                 400 


Leu Asn Arg Val Ile Gln Arg Leu Arg Ser Glu Ile Asp Asn Val Lys 
                405                 410                 415     


Lys Gln Ile Ser Asn Leu Gln Gln Ser Ile Ser Asp Ala Glu Gln Arg 
            420                 425                 430         


Gly Glu Asn Ala Leu Lys Asp Ala Lys Asn Lys Leu Asn Asp Leu Glu 
        435                 440                 445             


Asp Ala Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg Leu Leu Arg Asp 
    450                 455                 460                 


Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp Leu Glu Ile Ala 
465                 470                 475                 480 


Thr Tyr Arg Thr Leu Leu Glu Gly Glu Glu Ser Arg Met Ser Gly Glu 
                485                 490                 495     


Cys Ala Pro Asn Val Ser Val Ser Val Ser Thr Ser His Thr Thr Ile 
            500                 505                 510         


Ser Gly Gly Gly Ser Arg Gly Gly Gly Gly Gly Gly Tyr Gly Ser Gly 
        515                 520                 525             


Gly Ser Ser Tyr Gly Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Gly Gly Gly Arg Gly Ser Tyr Gly Ser Gly Gly Ser Ser Tyr Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly Gly Gly Gly His Gly 
                565                 570                 575     


Ser Tyr Gly Ser Gly Ser Ser Ser Gly Gly Tyr Arg Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Gly Gly Ser Ser Gly Gly Arg Gly Ser Gly Gly Gly Ser 
        595                 600                 605             


Ser Gly Gly Ser Ile Gly Gly Arg Gly Ser Ser Ser Gly Gly Val Lys 
    610                 615                 620                 


Ser Ser Gly Gly Ser Ser Ser Val Lys Phe Val Ser Thr Thr Tyr Ser 
625                 630                 635                 640 


Gly Val Thr Arg 
                


<210>  247
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ser His Gln Phe Ser Ser Gln Ser Ala Phe Ser Ser Met Ser Arg 
1               5                   10                  15      


Arg Val Tyr Ser Thr Ser Ser Ser Ala Gly Ser Gly Gly Gly Ser Pro 
            20                  25                  30          


Ala Val Gly Ser Val Cys Tyr Ala Arg Gly Arg Cys Gly Gly Gly Gly 
        35                  40                  45              


Tyr Gly Ile His Gly Arg Gly Phe Gly Ser Arg Ser Leu Tyr Asn Leu 
    50                  55                  60                  


Gly Gly Ser Arg Ser Ile Ser Ile Asn Leu Met Gly Arg Ser Thr Ser 
65                  70                  75                  80  


Gly Phe Cys Gln Gly Gly Gly Val Gly Gly Phe Gly Gly Gly Arg Gly 
                85                  90                  95      


Phe Gly Val Gly Ser Thr Gly Ala Gly Gly Phe Gly Gly Gly Gly Phe 
            100                 105                 110         


Gly Gly Ala Gly Phe Gly Thr Ser Asn Phe Gly Leu Gly Gly Phe Gly 
        115                 120                 125             


Pro Tyr Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Ser 
    130                 135                 140                 


Leu Leu Glu Pro Leu His Leu Glu Val Asp Pro Glu Ile Gln Arg Ile 
145                 150                 155                 160 


Lys Thr Gln Glu Arg Glu Gln Ile Met Val Leu Asn Asn Lys Phe Ala 
                165                 170                 175     


Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu 
            180                 185                 190         


Gln Thr Lys Trp Glu Leu Leu Gln Gln Val Asn Thr Ser Thr Gly Thr 
        195                 200                 205             


Asn Asn Leu Glu Pro Leu Leu Glu Asn Tyr Ile Gly Asp Leu Arg Arg 
    210                 215                 220                 


Gln Val Asp Leu Leu Ser Ala Glu Gln Met Arg Gln Asn Ala Glu Val 
225                 230                 235                 240 


Arg Ser Met Gln Asp Val Val Glu Asp Tyr Lys Ser Lys Tyr Glu Asp 
                245                 250                 255     


Glu Ile Asn Lys Arg Thr Gly Ser Glu Asn Asp Phe Val Val Leu Lys 
            260                 265                 270         


Lys Asp Val Asp Ala Ala Tyr Val Ser Lys Val Asp Leu Glu Ser Arg 
        275                 280                 285             


Val Asp Thr Leu Thr Gly Glu Val Asn Phe Leu Lys Tyr Leu Phe Leu 
    290                 295                 300                 


Thr Glu Leu Ser Gln Val Gln Thr His Ile Ser Asp Thr Asn Val Ile 
305                 310                 315                 320 


Leu Ser Met Asp Asn Asn Arg Ser Leu Asp Leu Asp Ser Ile Ile Asp 
                325                 330                 335     


Ala Val Arg Thr Gln Tyr Glu Leu Ile Ala Gln Arg Ser Lys Asp Glu 
            340                 345                 350         


Ala Glu Ala Leu Tyr Gln Thr Lys Tyr Gln Glu Leu Gln Ile Thr Ala 
        355                 360                 365             


Gly Arg His Gly Asp Asp Leu Lys Asn Ser Lys Met Glu Ile Ala Glu 
    370                 375                 380                 


Leu Asn Arg Thr Val Gln Arg Leu Gln Ala Glu Ile Ser Asn Val Lys 
385                 390                 395                 400 


Lys Gln Ile Glu Gln Met Gln Ser Leu Ile Ser Asp Ala Glu Glu Arg 
                405                 410                 415     


Gly Glu Gln Ala Leu Gln Asp Ala Trp Gln Lys Leu Gln Asp Leu Glu 
            420                 425                 430         


Glu Ala Leu Gln Gln Ser Lys Glu Glu Leu Ala Arg Leu Leu Arg Asp 
        435                 440                 445             


Tyr Gln Ala Met Leu Gly Val Lys Leu Ser Leu Asp Val Glu Ile Ala 
    450                 455                 460                 


Thr Tyr Arg Gln Leu Leu Glu Gly Glu Glu Ser Arg Met Ser Gly Glu 
465                 470                 475                 480 


Leu Gln Ser His Val Ser Ile Ser Val Gln Asn Ser Gln Val Ser Val 
                485                 490                 495     


Asn Gly Gly Ala Gly Gly Gly Gly Ser Tyr Gly Ser Gly Gly Tyr Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Arg Ser Tyr Arg Gly Gly 
        515                 520                 525             


Gly Ala Arg Gly Arg Ser Gly Gly Gly Tyr Gly Ser Gly Cys Gly Gly 
    530                 535                 540                 


Gly Gly Gly Ser Tyr Gly Gly Ser Gly Arg Ser Gly Arg Gly Ser Ser 
545                 550                 555                 560 


Arg Val Gln Ile Ile Gln Thr Ser Thr Asn Thr Ser His Arg Arg Ile 
                565                 570                 575     


Leu Glu 
        


<210>  248
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ser Cys Gln Ile Ser Cys Lys Ser Arg Gly Arg Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Phe Arg Gly Phe Ser Ser Gly Ser Ala Val Val Ser Gly Gly 
            20                  25                  30          


Ser Arg Arg Ser Thr Ser Ser Phe Ser Cys Leu Ser Arg His Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Ser Arg Ser Leu Val 
    50                  55                  60                  


Gly Leu Gly Gly Thr Lys Ser Ile Ser Ile Ser Val Ala Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Phe Gly Ala Ala Gly Gly Phe Gly Gly Arg Gly Gly Gly Phe 
                85                  90                  95      


Gly Gly Gly Ser Ser Phe Gly Gly Gly Ser Gly Phe Ser Gly Gly Gly 
            100                 105                 110         


Phe Gly Gly Gly Gly Phe Gly Gly Gly Arg Phe Gly Gly Phe Gly Gly 
        115                 120                 125             


Pro Gly Gly Val Gly Gly Leu Gly Gly Pro Gly Gly Phe Gly Pro Gly 
    130                 135                 140                 


Gly Tyr Pro Gly Gly Ile His Glu Val Ser Val Asn Gln Ser Leu Leu 
145                 150                 155                 160 


Gln Pro Leu Asn Val Lys Val Asp Pro Glu Ile Gln Asn Val Lys Ala 
                165                 170                 175     


Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe 
            180                 185                 190         


Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu Gln Thr 
        195                 200                 205             


Lys Trp Glu Leu Leu Gln Gln Met Asn Val Gly Thr Arg Pro Ile Asn 
    210                 215                 220                 


Leu Glu Pro Ile Phe Gln Gly Tyr Ile Asp Ser Leu Lys Arg Tyr Leu 
225                 230                 235                 240 


Asp Gly Leu Thr Ala Glu Arg Thr Ser Gln Asn Ser Glu Leu Asn Asn 
                245                 250                 255     


Met Gln Asp Leu Val Glu Asp Tyr Lys Lys Lys Tyr Glu Asp Glu Ile 
            260                 265                 270         


Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe Val Thr Leu Lys Lys Asp 
        275                 280                 285             


Val Asp Asn Ala Tyr Met Ile Lys Val Glu Leu Gln Ser Lys Val Asp 
    290                 295                 300                 


Leu Leu Asn Gln Glu Ile Glu Phe Leu Lys Val Leu Tyr Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Gln Ile His Gln Ser Val Thr Asp Thr Asn Val Ile Leu Ser 
                325                 330                 335     


Met Asp Asn Ser Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val 
            340                 345                 350         


Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Lys Glu Glu Ala Glu 
        355                 360                 365             


Ala Leu Tyr His Ser Lys Tyr Glu Glu Leu Gln Val Thr Val Gly Arg 
    370                 375                 380                 


His Gly Asp Ser Leu Lys Glu Ile Lys Ile Glu Ile Ser Glu Leu Asn 
385                 390                 395                 400 


Arg Val Ile Gln Arg Leu Gln Gly Glu Ile Ala His Val Lys Lys Gln 
                405                 410                 415     


Cys Lys Asn Val Gln Asp Ala Ile Ala Asp Ala Glu Gln Arg Gly Glu 
            420                 425                 430         


His Ala Leu Lys Asp Ala Arg Asn Lys Leu Asn Asp Leu Glu Glu Ala 
        435                 440                 445             


Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg Leu Leu Arg Asp Tyr Gln 
    450                 455                 460                 


Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr Tyr 
465                 470                 475                 480 


Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Asp Leu Ser 
                485                 490                 495     


Ser Asn Val Thr Val Ser Val Thr Ser Ser Thr Ile Ser Ser Asn Val 
            500                 505                 510         


Ala Ser Lys Ala Ala Phe Gly Gly Ser Gly Gly Arg Gly Ser Ser Ser 
        515                 520                 525             


Gly Gly Gly Tyr Ser Ser Gly Ser Ser Ser Tyr Gly Ser Gly Gly Arg 
    530                 535                 540                 


Gln Ser Gly Ser Arg Gly Gly Ser Gly Gly Gly Gly Ser Ile Ser Gly 
545                 550                 555                 560 


Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly Gly Arg Tyr Gly Ser Gly 
                565                 570                 575     


Gly Gly Ser Lys Gly Gly Ser Ile Ser Gly Gly Gly Tyr Gly Ser Gly 
            580                 585                 590         


Gly Gly Lys His Ser Ser Gly Gly Gly Ser Arg Gly Gly Ser Ser Ser 
        595                 600                 605             


Gly Gly Gly Tyr Gly Ser Gly Gly Gly Gly Ser Ser Ser Val Lys Gly 
    610                 615                 620                 


Ser Ser Gly Glu Ala Phe Gly Ser Ser Val Thr Phe Ser Phe Arg 
625                 630                 635                 


<210>  249
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Ile Ala Arg Gln Gln Cys Val Arg Gly Gly Pro Arg Gly Phe Ser 
1               5                   10                  15      


Cys Gly Ser Ala Ile Val Gly Gly Gly Lys Arg Gly Ala Phe Ser Ser 
            20                  25                  30          


Val Ser Met Ser Gly Gly Ala Gly Arg Cys Ser Ser Gly Gly Phe Gly 
        35                  40                  45              


Ser Arg Ser Leu Tyr Asn Leu Arg Gly Asn Lys Ser Ile Ser Met Ser 
    50                  55                  60                  


Val Ala Gly Ser Arg Gln Gly Ala Cys Phe Gly Gly Ala Gly Gly Phe 
65                  70                  75                  80  


Gly Thr Gly Gly Phe Gly Ala Gly Gly Phe Gly Ala Gly Phe Gly Thr 
                85                  90                  95      


Gly Gly Phe Gly Gly Gly Phe Gly Gly Ser Phe Ser Gly Lys Gly Gly 
            100                 105                 110         


Pro Gly Phe Pro Val Cys Pro Ala Gly Gly Ile Gln Glu Val Thr Ile 
        115                 120                 125             


Asn Gln Ser Leu Leu Thr Pro Leu His Val Glu Ile Asp Pro Glu Ile 
    130                 135                 140                 


Gln Lys Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Leu Leu Asn Asn 
145                 150                 155                 160 


Lys Phe Ala Ser Phe Ile Asp Lys Val Gln Phe Leu Glu Gln Gln Asn 
                165                 170                 175     


Lys Val Leu Glu Thr Lys Trp Asn Leu Leu Gln Gln Gln Thr Thr Thr 
            180                 185                 190         


Thr Ser Ser Lys Asn Leu Glu Pro Leu Phe Glu Thr Tyr Leu Ser Val 
        195                 200                 205             


Leu Arg Lys Gln Leu Asp Thr Leu Gly Asn Asp Lys Gly Arg Leu Gln 
    210                 215                 220                 


Ser Glu Leu Lys Thr Met Gln Asp Ser Val Glu Asp Phe Lys Thr Lys 
225                 230                 235                 240 


Tyr Glu Glu Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe Val 
                245                 250                 255     


Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Leu Asn Lys Val Glu Leu 
            260                 265                 270         


Glu Ala Lys Val Asp Ser Leu Asn Asp Glu Ile Asn Phe Leu Lys Val 
        275                 280                 285             


Leu Tyr Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp Thr 
    290                 295                 300                 


Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser 
305                 310                 315                 320 


Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser 
                325                 330                 335     


Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys Val Gln Gln Leu Gln 
            340                 345                 350         


Ile Ser Val Asp Gln His Gly Asp Asn Leu Lys Asn Thr Lys Ser Glu 
        355                 360                 365             


Ile Ala Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Glu 
    370                 375                 380                 


Asn Ile Lys Lys Gln Cys Gln Thr Leu Gln Val Ser Val Ala Asp Ala 
385                 390                 395                 400 


Glu Gln Arg Gly Glu Asn Ala Leu Lys Asp Ala His Ser Lys Arg Val 
                405                 410                 415     


Glu Leu Glu Ala Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala Arg Met 
            420                 425                 430         


Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala Leu Asp Ile 
        435                 440                 445             


Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Tyr Arg Met 
    450                 455                 460                 


Ser Gly Glu Cys Gln Ser Ala Val Ser Ile Ser Val Val Ser Gly Ser 
465                 470                 475                 480 


Thr Ser Thr Gly Gly Ile Ser Gly Gly Leu Gly Ser Gly Ser Gly Phe 
                485                 490                 495     


Gly Leu Ser Ser Gly Phe Gly Ser Gly Ser Gly Ser Gly Phe Gly Phe 
            500                 505                 510         


Gly Gly Ser Val Ser Gly Ser Ser Ser Ser Lys Ile Ile Ser Thr Thr 
        515                 520                 525             


Thr Leu Asn Lys Arg Arg 
    530                 


<210>  250
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  251
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Asn Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Asn Met Gln Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Ile Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Thr Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  252
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ser Ile His Phe Ser Ser Pro Val Phe Thr Ser Arg Ser Ala Ala 
1               5                   10                  15      


Phe Ser Gly Arg Gly Ala Gln Val Arg Leu Ser Ser Ala Arg Pro Gly 
            20                  25                  30          


Gly Leu Gly Ser Ser Ser Leu Tyr Gly Leu Gly Ala Ser Arg Pro Arg 
        35                  40                  45              


Val Ala Val Arg Ser Ala Tyr Gly Gly Pro Val Gly Ala Gly Ile Arg 
    50                  55                  60                  


Glu Val Thr Ile Asn Gln Ser Leu Leu Ala Pro Leu Arg Leu Asp Ala 
65                  70                  75                  80  


Asp Pro Ser Leu Gln Arg Val Arg Gln Glu Glu Ser Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Trp Thr Leu Leu Gln Glu 
        115                 120                 125             


Gln Lys Ser Ala Lys Ser Ser Arg Leu Pro Asp Ile Phe Glu Ala Gln 
    130                 135                 140                 


Ile Ala Gly Leu Arg Gly Gln Leu Glu Ala Leu Gln Val Asp Gly Gly 
145                 150                 155                 160 


Arg Leu Glu Ala Glu Leu Arg Ser Met Gln Asp Val Val Glu Asp Phe 
                165                 170                 175     


Lys Asn Lys Tyr Glu Asp Glu Ile Asn His Arg Thr Ala Ala Glu Asn 
            180                 185                 190         


Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Ser Lys 
        195                 200                 205             


Val Glu Leu Glu Ala Lys Val Asp Ala Leu Asn Asp Glu Ile Asn Phe 
    210                 215                 220                 


Leu Arg Thr Leu Asn Glu Thr Glu Leu Thr Glu Leu Gln Ser Gln Ile 
225                 230                 235                 240 


Ser Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp 
                245                 250                 255     


Leu Asp Gly Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Met Ala 
            260                 265                 270         


Lys Cys Ser Arg Ala Glu Ala Glu Ala Trp Tyr Gln Thr Lys Phe Glu 
        275                 280                 285             


Thr Leu Gln Ala Gln Ala Gly Lys His Gly Asp Asp Leu Arg Asn Thr 
    290                 295                 300                 


Arg Asn Glu Ile Ser Glu Met Asn Arg Ala Ile Gln Arg Leu Gln Ala 
305                 310                 315                 320 


Glu Ile Asp Asn Ile Lys Asn Gln Arg Ala Lys Leu Glu Ala Ala Ile 
                325                 330                 335     


Ala Glu Ala Glu Glu Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Ala 
            340                 345                 350         


Lys Gln Glu Glu Leu Glu Ala Ala Leu Gln Arg Gly Lys Gln Asp Met 
        355                 360                 365             


Ala Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala 
    370                 375                 380                 


Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
385                 390                 395                 400 


Ser Arg Leu Ala Gly Asp Gly Val Gly Ala Val Asn Ile Ser Val Met 
                405                 410                 415     


Asn Ser Thr Gly Gly Ser Ser Ser Gly Gly Gly Ile Gly Leu Thr Leu 
            420                 425                 430         


Gly Gly Thr Met Gly Ser Asn Ala Leu Ser Phe Ser Ser Ser Ala Gly 
        435                 440                 445             


Pro Gly Leu Leu Lys Ala Tyr Ser Ile Arg Thr Ala Ser Ala Ser Arg 
    450                 455                 460                 


Arg Ser Ala Arg Asp 
465                 


<210>  253
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly 
1               5                   10                  15      


Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg 
            20                  25                  30          


Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly 
        35                  40                  45              


Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr 
    50                  55                  60                  


Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val 
65                  70                  75                  80  


Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 
        115                 120                 125             


Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile 
    130                 135                 140                 


Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 
145                 150                 155                 160 


Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys 
                165                 170                 175     


Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu 
            180                 185                 190         


Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val 
        195                 200                 205             


Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 
    210                 215                 220                 


Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 
225                 230                 235                 240 


Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met 
                245                 250                 255     


Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn 
            260                 265                 270         


Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 
        275                 280                 285             


Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys 
    290                 295                 300                 


Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu 
305                 310                 315                 320 


Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala 
                325                 330                 335     


Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys 
            340                 345                 350         


Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala 
        355                 360                 365             


Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu 
    370                 375                 380                 


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 
385                 390                 395                 400 


Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr 
                405                 410                 415     


Ser Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser 
            420                 425                 430         


Pro Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly 
        435                 440                 445             


Ser Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys 
    450                 455                 460                 


Lys Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val 
465                 470                 475                 480 


Leu Pro Lys 
            


<210>  254
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Glu Ser Thr Pro Phe Ser Gly Val Ala Asn Gln Ile His Thr Leu 
1               5                   10                  15      


Cys Glu Arg Pro Thr Tyr Gly Glu Val Lys Asp Gly Ala Leu Asp Val 
            20                  25                  30          


Lys Arg Gln His Lys Cys Pro Gly Pro Thr Ser Gly Pro Ser Pro Gly 
        35                  40                  45              


Thr Asn Leu Ser Gly Cys Ile Arg Met Asn Asp Asp Pro Ser Met Glu 
    50                  55                  60                  


Glu Asn Gly Val Glu Arg Val Cys Pro Glu Ser Leu Leu Gln Ser Arg 
65                  70                  75                  80  


Glu Tyr Ser Ser Leu Pro Leu Pro Arg His Thr Ser Ser Thr Asp Gly 
                85                  90                  95      


Thr Ile Thr Ser Ser Asp Pro Gly Leu Glu Ile Leu Asn Met Ala Ser 
            100                 105                 110         


Cys Asp Leu Asp Arg Asn Ser Leu Cys Lys Lys Glu Glu Asp Thr Arg 
        115                 120                 125             


Ser Ala Ser Pro Thr Ile Glu Ala Gln Gly Thr Ser Pro Ala His Asp 
    130                 135                 140                 


Asn Ile Ala Phe Gln Asp Ser Thr Ser Lys Asp Lys Thr Ile Leu Asn 
145                 150                 155                 160 


Leu Glu Ala Lys Glu Glu Pro Glu Thr Ile Glu Glu His Lys Lys Glu 
                165                 170                 175     


His Ala Ser Gly Asp Ser Val Val Ser Pro Leu Pro Val Thr Thr Val 
            180                 185                 190         


Lys Ser Val Asn Leu Arg Gln Ser Glu Asn Thr Ser Ala Asn Glu Lys 
        195                 200                 205             


Glu Val Glu Ala Glu Phe Leu Arg Leu Ser Leu Gly Phe Lys Cys Asp 
    210                 215                 220                 


Trp Phe Thr Leu Glu Lys Arg Val Lys Leu Glu Glu Arg Ser Arg Asp 
225                 230                 235                 240 


Leu Ala Glu Glu Asn Leu Lys Lys Glu Ile Thr Asn Cys Leu Lys Leu 
                245                 250                 255     


Leu Glu Ser Leu Thr Pro Leu Cys Glu Asp Asp Asn Gln Ala Gln Glu 
            260                 265                 270         


Ile Ile Lys Lys Leu Glu Lys Ser Ile Lys Phe Leu Ser Gln Cys Ala 
        275                 280                 285             


Ala Arg Val Ala Ser Arg Ala Glu Met Leu Gly Ala Ile Asn Gln Glu 
    290                 295                 300                 


Ser Arg Val Ser Lys Ala Val Glu Val Met Ile Gln His Val Glu Asn 
305                 310                 315                 320 


Leu Lys Arg Met Tyr Ala Lys Glu His Ala Glu Leu Glu Glu Leu Lys 
                325                 330                 335     


Gln Val Leu Leu Gln Asn Glu Arg Ser Phe Asn Pro Leu Glu Asp Asp 
            340                 345                 350         


Asp Asp Cys Gln Ile Lys Lys Arg Ser Ala Ser Leu Asn Ser Lys Pro 
        355                 360                 365             


Ser Ser Leu Arg Arg Val Thr Ile Ala Ser Leu Pro Arg Asn Ile Gly 
    370                 375                 380                 


Asn Ala Gly Met Val Ala Gly Met Glu Asn Asn Asp Arg Phe Ser Arg 
385                 390                 395                 400 


Arg Ser Ser Ser Trp Arg Ile Leu Gly Ser Lys Gln Ser Glu His Arg 
                405                 410                 415     


Pro Ser Leu Pro Arg Phe Ile Ser Thr Tyr Ser Trp Ala Asp Ala Glu 
            420                 425                 430         


Glu Glu Lys Cys Glu Leu Lys Thr Lys Asp Asp Ser Glu Pro Ser Gly 
        435                 440                 445             


Glu Glu Thr Val Glu Arg Thr Arg Lys Pro Ser Leu Ser Glu Lys Lys 
    450                 455                 460                 


Asn Asn Pro Ser Lys Trp Asp Val Ser Ser Val Tyr Asp Thr Ile Ala 
465                 470                 475                 480 


Ser Trp Ala Thr Asn Leu Lys Ser Ser Ile Arg Lys Ala Asn Lys Ala 
                485                 490                 495     


Leu Trp Leu Ser Ile Ala Phe Ile Val Leu Phe Ala Ala Leu Met Ser 
            500                 505                 510         


Phe Leu Thr Gly Gln Leu Phe Gln Lys Ser Val Asp Ala Ala Pro Thr 
        515                 520                 525             


Gln Gln Glu Asp Ser Trp Thr Ser Leu Glu His Ile Leu Trp Pro Phe 
    530                 535                 540                 


Thr Arg Leu Arg His Asn Gly Pro Pro Pro Val 
545                 550                 555 


<210>  255
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ala Pro Lys Lys Asp Val Lys Lys Pro Val Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Lys 
            20                  25                  30          


Pro Lys Glu Glu Lys Ile Asp Leu Ser Ala Ile Lys Ile Glu Phe Ser 
        35                  40                  45              


Lys Glu Gln Gln Asp Glu Phe Lys Glu Ala Phe Leu Leu Phe Asp Arg 
    50                  55                  60                  


Thr Gly Asp Ser Lys Ile Thr Leu Ser Gln Val Gly Asp Val Leu Arg 
65                  70                  75                  80  


Ala Leu Gly Thr Asn Pro Thr Asn Ala Glu Val Arg Lys Val Leu Gly 
                85                  90                  95      


Asn Pro Ser Asn Glu Glu Leu Asn Ala Lys Lys Ile Glu Phe Glu Gln 
            100                 105                 110         


Phe Leu Pro Met Met Gln Ala Ile Ser Asn Asn Lys Asp Gln Ala Thr 
        115                 120                 125             


Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly Asn 
    130                 135                 140                 


Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu Gly 
145                 150                 155                 160 


Glu Lys Met Lys Glu Glu Glu Val Glu Ala Leu Met Ala Gly Gln Glu 
                165                 170                 175     


Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile Met 
            180                 185                 190         


Ser Ile 
        


<210>  256
<211>  1941
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ser Ser Asp Ser Glu Leu Ala Val Phe Gly Glu Ala Ala Pro Phe 
1               5                   10                  15      


Leu Arg Lys Ser Glu Arg Glu Arg Ile Glu Ala Gln Asn Arg Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Ser Val Phe Val Ala Glu Pro Lys Glu Ser Phe Val 
        35                  40                  45              


Lys Gly Thr Ile Gln Ser Arg Glu Gly Gly Lys Val Thr Val Lys Thr 
    50                  55                  60                  


Glu Gly Gly Ala Thr Leu Thr Val Lys Asp Asp Gln Val Phe Pro Met 
65                  70                  75                  80  


Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His 
                85                  90                  95      


Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Thr Ala Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu 
        195                 200                 205             


Glu Ile Thr Ser Gly Lys Ile Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Val Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Thr Ser Asn Lys Lys Pro Glu Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Pro Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Ser Val Ala Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Asp Ile Leu Gly Phe Thr Asn Glu Glu Lys Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Leu Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Ser Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Glu Gln Val Ser Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Glu Lys Met Phe Leu Trp Met Val Ala Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Ala Asn Phe Gln Lys Pro Lys Val Val Lys Gly Lys Ala 
                565                 570                 575     


Glu Ala His Phe Ala Leu Ile His Tyr Ala Gly Val Val Asp Tyr Asn 
            580                 585                 590         


Ile Thr Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Gln Leu Phe 
    610                 615                 620                 


Ser Gly Ala Gln Thr Ala Glu Gly Glu Gly Ala Gly Gly Gly Ala Lys 
625                 630                 635                 640 


Lys Gly Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu 
                645                 650                 655     


Phe Arg Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His 
            660                 665                 670         


Pro His Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly 
        675                 680                 685             


Ala Met Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val 
    690                 695                 700                 


Leu Glu Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu 
705                 710                 715                 720 


Tyr Ala Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile 
                725                 730                 735     


Pro Glu Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu 
            740                 745                 750         


Ala Ser Ile Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys 
        755                 760                 765             


Val Phe Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp 
    770                 775                 780                 


Asp Lys Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Arg Cys Arg Gly 
785                 790                 795                 800 


Phe Leu Ala Arg Val Glu Tyr Gln Arg Met Val Glu Arg Arg Glu Ala 
                805                 810                 815     


Ile Phe Cys Ile Gln Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His 
            820                 825                 830         


Trp Pro Trp Met Lys Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser 
        835                 840                 845             


Ala Glu Thr Glu Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys 
    850                 855                 860                 


Ile Lys Asp Glu Leu Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu 
865                 870                 875                 880 


Glu Lys Met Val Thr Leu Leu Lys Glu Lys Asn Asp Leu Gln Leu Gln 
                885                 890                 895     


Val Gln Ala Glu Ala Glu Gly Leu Ala Asp Ala Glu Glu Arg Cys Asp 
            900                 905                 910         


Gln Leu Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val 
        915                 920                 925             


Thr Glu Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala 
    930                 935                 940                 


Lys Lys Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile 
945                 950                 955                 960 


Asp Asp Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala 
                965                 970                 975     


Thr Glu Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp 
            980                 985                 990         


Glu Thr Ile Ala Lys Leu Thr Lys  Glu Lys Lys Ala Leu  Gln Glu Ala 
        995                 1000                 1005             


His Gln  Gln Thr Leu Asp Asp  Leu Gln Ala Glu Glu  Asp Lys Val 
    1010                 1015                 1020             


Asn Thr  Leu Thr Lys Ala Lys  Ile Lys Leu Glu Gln  Gln Val Asp 
    1025                 1030                 1035             


Asp Leu  Glu Gly Ser Leu Glu  Gln Glu Lys Lys Leu  Arg Met Asp 
    1040                 1045                 1050             


Leu Glu  Arg Ala Lys Arg Lys  Leu Glu Gly Asp Leu  Lys Leu Ala 
    1055                 1060                 1065             


Gln Glu  Ser Ile Met Asp Ile  Glu Asn Glu Lys Gln  Gln Leu Asp 
    1070                 1075                 1080             


Glu Lys  Leu Lys Lys Lys Glu  Phe Glu Ile Ser Asn  Leu Gln Ser 
    1085                 1090                 1095             


Lys Ile  Glu Asp Glu Gln Ala  Leu Gly Ile Gln Leu  Gln Lys Lys 
    1100                 1105                 1110             


Ile Lys  Glu Leu Gln Ala Arg  Ile Glu Glu Leu Glu  Glu Glu Ile 
    1115                 1120                 1125             


Glu Ala  Glu Arg Ala Ser Arg  Ala Lys Ala Glu Lys  Gln Arg Ser 
    1130                 1135                 1140             


Asp Leu  Ser Arg Glu Leu Glu  Glu Ile Ser Glu Arg  Leu Glu Glu 
    1145                 1150                 1155             


Ala Gly  Gly Ala Thr Ser Ala  Gln Ile Glu Met Asn  Lys Lys Arg 
    1160                 1165                 1170             


Glu Ala  Glu Phe Gln Lys Met  Arg Arg Asp Leu Glu  Glu Ala Thr 
    1175                 1180                 1185             


Leu Gln  His Glu Ala Thr Ala  Ala Thr Leu Arg Lys  Lys His Ala 
    1190                 1195                 1200             


Asp Ser  Val Ala Glu Leu Gly  Glu Gln Ile Asp Asn  Leu Gln Arg 
    1205                 1210                 1215             


Val Lys  Gln Lys Leu Glu Lys  Glu Lys Ser Glu Met  Lys Met Glu 
    1220                 1225                 1230             


Ile Asp  Asp Leu Ala Ser Asn  Val Glu Thr Val Ser  Lys Ala Lys 
    1235                 1240                 1245             


Gly Asn  Leu Glu Lys Met Cys  Arg Thr Leu Glu Asp  Gln Leu Ser 
    1250                 1255                 1260             


Glu Leu  Lys Ser Lys Glu Glu  Glu Gln Gln Arg Leu  Ile Asn Asp 
    1265                 1270                 1275             


Leu Thr  Ala Gln Arg Gly Arg  Leu Gln Thr Glu Ser  Gly Glu Phe 
    1280                 1285                 1290             


Ser Arg  Gln Leu Asp Glu Lys  Glu Ala Leu Val Ser  Gln Leu Ser 
    1295                 1300                 1305             


Arg Gly  Lys Gln Ala Phe Thr  Gln Gln Ile Glu Glu  Leu Lys Arg 
    1310                 1315                 1320             


Gln Leu  Glu Glu Glu Ile Lys  Ala Lys Asn Ala Leu  Ala His Ala 
    1325                 1330                 1335             


Leu Gln  Ser Ser Arg His Asp  Cys Asp Leu Leu Arg  Glu Gln Tyr 
    1340                 1345                 1350             


Glu Glu  Glu Gln Glu Ser Lys  Ala Glu Leu Gln Arg  Ala Leu Ser 
    1355                 1360                 1365             


Lys Ala  Asn Thr Glu Val Ala  Gln Trp Arg Thr Lys  Tyr Glu Thr 
    1370                 1375                 1380             


Asp Ala  Ile Gln Arg Thr Glu  Glu Leu Glu Glu Ala  Lys Lys Lys 
    1385                 1390                 1395             


Leu Ala  Gln Arg Leu Gln Ala  Ala Glu Glu His Val  Glu Ala Val 
    1400                 1405                 1410             


Asn Ala  Lys Cys Ala Ser Leu  Glu Lys Thr Lys Gln  Arg Leu Gln 
    1415                 1420                 1425             


Asn Glu  Val Glu Asp Leu Met  Leu Asp Val Glu Arg  Thr Asn Ala 
    1430                 1435                 1440             


Ala Cys  Ala Ala Leu Asp Lys  Lys Gln Arg Asn Phe  Asp Lys Ile 
    1445                 1450                 1455             


Leu Ala  Glu Trp Lys Gln Lys  Cys Glu Glu Thr His  Ala Glu Leu 
    1460                 1465                 1470             


Glu Ala  Ser Gln Lys Glu Ala  Arg Ser Leu Gly Thr  Glu Leu Phe 
    1475                 1480                 1485             


Lys Ile  Lys Asn Ala Tyr Glu  Glu Ser Leu Asp Gln  Leu Glu Thr 
    1490                 1495                 1500             


Leu Lys  Arg Glu Asn Lys Asn  Leu Gln Gln Glu Ile  Ser Asp Leu 
    1505                 1510                 1515             


Thr Glu  Gln Ile Ala Glu Gly  Gly Lys Arg Ile His  Glu Leu Glu 
    1520                 1525                 1530             


Lys Ile  Lys Lys Gln Val Glu  Gln Glu Lys Cys Glu  Leu Gln Ala 
    1535                 1540                 1545             


Ala Leu  Glu Glu Ala Glu Ala  Ser Leu Glu His Glu  Glu Gly Lys 
    1550                 1555                 1560             


Ile Leu  Arg Ile Gln Leu Glu  Leu Asn Gln Val Lys  Ser Glu Val 
    1565                 1570                 1575             


Asp Arg  Lys Ile Ala Glu Lys  Asp Glu Glu Ile Asp  Gln Leu Lys 
    1580                 1585                 1590             


Arg Asn  His Ile Arg Ile Val  Glu Ser Met Gln Ser  Thr Leu Asp 
    1595                 1600                 1605             


Ala Glu  Ile Arg Ser Arg Asn  Asp Ala Ile Arg Leu  Lys Lys Lys 
    1610                 1615                 1620             


Met Glu  Gly Asp Leu Asn Glu  Met Glu Ile Gln Leu  Asn His Ala 
    1625                 1630                 1635             


Asn Arg  Met Ala Ala Glu Ala  Leu Arg Asn Tyr Arg  Asn Thr Gln 
    1640                 1645                 1650             


Gly Ile  Leu Lys Asp Thr Gln  Ile His Leu Asp Asp  Ala Leu Arg 
    1655                 1660                 1665             


Ser Gln  Glu Asp Leu Lys Glu  Gln Leu Ala Met Val  Glu Arg Arg 
    1670                 1675                 1680             


Ala Asn  Leu Leu Gln Ala Glu  Ile Glu Glu Leu Arg  Ala Thr Leu 
    1685                 1690                 1695             


Glu Gln  Thr Glu Arg Ser Arg  Lys Ile Ala Glu Gln  Glu Leu Leu 
    1700                 1705                 1710             


Asp Ala  Ser Glu Arg Val Gln  Leu Leu His Thr Gln  Asn Thr Ser 
    1715                 1720                 1725             


Leu Ile  Asn Thr Lys Lys Lys  Leu Glu Thr Asp Ile  Ser Gln Met 
    1730                 1735                 1740             


Gln Gly  Glu Met Glu Asp Ile  Leu Gln Glu Ala Arg  Asn Ala Glu 
    1745                 1750                 1755             


Glu Lys  Ala Lys Lys Ala Ile  Thr Asp Ala Ala Met  Met Ala Glu 
    1760                 1765                 1770             


Glu Leu  Lys Lys Glu Gln Asp  Thr Ser Ala His Leu  Glu Arg Met 
    1775                 1780                 1785             


Lys Lys  Asn Met Glu Gln Thr  Val Lys Asp Leu Gln  Leu Arg Leu 
    1790                 1795                 1800             


Asp Glu  Ala Glu Gln Leu Ala  Leu Lys Gly Gly Lys  Lys Gln Ile 
    1805                 1810                 1815             


Gln Lys  Leu Glu Ala Arg Val  Arg Glu Leu Glu Gly  Glu Val Glu 
    1820                 1825                 1830             


Ser Glu  Gln Lys Arg Asn Ala  Glu Ala Val Lys Gly  Leu Arg Lys 
    1835                 1840                 1845             


His Glu  Arg Arg Val Lys Glu  Leu Thr Tyr Gln Thr  Glu Glu Asp 
    1850                 1855                 1860             


Arg Lys  Asn Ile Leu Arg Leu  Gln Asp Leu Val Asp  Lys Leu Gln 
    1865                 1870                 1875             


Ala Lys  Val Lys Ser Tyr Lys  Arg Gln Ala Glu Glu  Ala Glu Glu 
    1880                 1885                 1890             


Gln Ser  Asn Thr Asn Leu Ala  Lys Phe Arg Lys Leu  Gln His Glu 
    1895                 1900                 1905             


Leu Glu  Glu Ala Glu Glu Arg  Ala Asp Ile Ala Glu  Ser Gln Val 
    1910                 1915                 1920             


Asn Lys  Leu Arg Val Lys Ser  Arg Glu Val His Thr  Lys Val Ile 
    1925                 1930                 1935             


Ser Glu  Glu 
    1940     


<210>  257
<211>  1996
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Met Arg Thr Thr Glu Asp Phe His Lys Pro Ser Ala Thr Leu Asn 
1               5                   10                  15      


Ser Asn Thr Ala Thr Lys Gly Arg Tyr Ile Tyr Leu Glu Ala Phe Leu 
            20                  25                  30          


Glu Gly Gly Ala Pro Trp Gly Phe Thr Leu Lys Gly Gly Leu Glu His 
        35                  40                  45              


Gly Glu Pro Leu Ile Ile Ser Lys Val Glu Glu Gly Gly Lys Ala Asp 
    50                  55                  60                  


Thr Leu Ser Ser Lys Leu Gln Ala Gly Asp Glu Val Val His Ile Asn 
65                  70                  75                  80  


Glu Val Thr Leu Ser Ser Ser Arg Lys Glu Ala Val Ser Leu Val Lys 
                85                  90                  95      


Gly Ser Tyr Lys Thr Leu Arg Leu Val Val Arg Arg Asp Val Cys Thr 
            100                 105                 110         


Asp Pro Gly His Ala Asp Thr Gly Ala Ser Asn Phe Val Ser Pro Glu 
        115                 120                 125             


His Leu Thr Ser Gly Pro Gln His Arg Lys Ala Ala Trp Ser Gly Gly 
    130                 135                 140                 


Val Lys Leu Arg Leu Lys His Arg Arg Ser Glu Pro Ala Gly Arg Pro 
145                 150                 155                 160 


His Ser Trp His Thr Thr Lys Ser Gly Glu Lys Gln Pro Asp Ala Ser 
                165                 170                 175     


Met Met Gln Ile Ser Gln Gly Met Ile Gly Pro Pro Trp His Gln Ser 
            180                 185                 190         


Tyr His Ser Ser Ser Ser Thr Ser Asp Leu Ser Asn Tyr Asp His Ala 
        195                 200                 205             


Tyr Leu Arg Arg Ser Pro Asp Gln Cys Ser Ser Gln Gly Ser Met Glu 
    210                 215                 220                 


Ser Leu Glu Pro Ser Gly Ala Tyr Pro Pro Cys His Leu Ser Pro Ala 
225                 230                 235                 240 


Lys Ser Thr Gly Ser Ile Asp Gln Leu Ser His Phe His Asn Lys Arg 
                245                 250                 255     


Asp Ser Ala Tyr Ser Ser Phe Ser Thr Ser Ser Ser Ile Leu Glu Tyr 
            260                 265                 270         


Pro His Pro Gly Ile Ser Gly Arg Glu Arg Ser Gly Ser Met Asp Asn 
        275                 280                 285             


Thr Ser Ala Arg Gly Gly Leu Leu Glu Gly Met Arg Gln Ala Asp Ile 
    290                 295                 300                 


Arg Tyr Val Lys Thr Val Tyr Asp Thr Arg Arg Gly Val Ser Ala Glu 
305                 310                 315                 320 


Tyr Glu Val Asn Ser Ser Ala Leu Leu Leu Gln Gly Arg Glu Ala Arg 
                325                 330                 335     


Ala Ser Ala Asn Gly Gln Gly Tyr Asp Lys Trp Ser Asn Ile Pro Arg 
            340                 345                 350         


Gly Lys Gly Val Pro Pro Pro Ser Trp Ser Gln Gln Cys Pro Ser Ser 
        355                 360                 365             


Leu Glu Thr Ala Thr Asp Asn Leu Pro Pro Lys Val Gly Ala Pro Leu 
    370                 375                 380                 


Pro Pro Ala Arg Ser Asp Ser Tyr Ala Ala Phe Arg His Arg Glu Arg 
385                 390                 395                 400 


Pro Ser Ser Trp Ser Ser Leu Asp Gln Lys Arg Leu Cys Arg Pro Gln 
                405                 410                 415     


Ala Asn Ser Leu Gly Ser Leu Lys Ser Pro Phe Ile Glu Glu Gln Leu 
            420                 425                 430         


His Thr Val Leu Glu Lys Ser Pro Glu Asn Ser Pro Pro Val Lys Pro 
        435                 440                 445             


Lys His Asn Tyr Thr Gln Lys Ala Gln Pro Gly Gln Pro Leu Leu Pro 
    450                 455                 460                 


Thr Ser Ile Tyr Pro Val Pro Ser Leu Glu Pro His Phe Ala Gln Val 
465                 470                 475                 480 


Pro Gln Pro Ser Val Ser Ser Asn Gly Met Leu Tyr Pro Ala Leu Ala 
                485                 490                 495     


Lys Glu Ser Gly Tyr Ile Ala Pro Gln Gly Ala Cys Asn Lys Met Ala 
            500                 505                 510         


Thr Ile Asp Glu Asn Gly Asn Gln Asn Gly Ser Gly Arg Pro Gly Phe 
        515                 520                 525             


Ala Phe Cys Gln Pro Leu Glu His Asp Leu Leu Ser Pro Val Glu Lys 
    530                 535                 540                 


Lys Pro Glu Ala Thr Ala Lys Tyr Val Pro Ser Lys Val His Phe Cys 
545                 550                 555                 560 


Ser Val Pro Glu Asn Glu Glu Asp Ala Ser Leu Lys Arg His Leu Thr 
                565                 570                 575     


Pro Pro Gln Gly Asn Ser Pro His Ser Asn Glu Arg Lys Ser Thr His 
            580                 585                 590         


Ser Asn Lys Pro Ser Ser His Pro His Ser Leu Lys Cys Pro Gln Ala 
        595                 600                 605             


Gln Ala Trp Gln Ala Gly Glu Asp Lys Arg Ser Ser Arg Leu Ser Glu 
    610                 615                 620                 


Pro Trp Glu Gly Asp Phe Gln Glu Asp His Asn Ala Asn Leu Trp Arg 
625                 630                 635                 640 


Arg Leu Glu Arg Glu Gly Leu Gly Gln Ser Leu Ser Gly Asn Phe Gly 
                645                 650                 655     


Lys Thr Lys Ser Ala Phe Ser Ser Leu Gln Asn Ile Pro Glu Ser Leu 
            660                 665                 670         


Arg Arg His Ser Ser Leu Glu Leu Gly Arg Gly Thr Gln Glu Gly Tyr 
        675                 680                 685             


Pro Gly Gly Arg Pro Thr Cys Ala Val Asn Thr Lys Ala Glu Asp Pro 
    690                 695                 700                 


Gly Arg Lys Ala Ala Pro Asp Leu Gly Ser His Leu Asp Arg Gln Val 
705                 710                 715                 720 


Ser Tyr Pro Arg Pro Glu Gly Arg Thr Gly Ala Ser Ala Ser Phe Asn 
                725                 730                 735     


Ser Thr Asp Pro Ser Pro Glu Glu Pro Pro Ala Pro Ser His Pro His 
            740                 745                 750         


Thr Ser Ser Leu Gly Arg Arg Gly Pro Gly Pro Gly Ser Ala Ser Ala 
        755                 760                 765             


Leu Gln Gly Phe Gln Tyr Gly Lys Pro His Cys Ser Val Leu Glu Lys 
    770                 775                 780                 


Val Ser Lys Phe Glu Gln Arg Glu Gln Gly Ser Gln Arg Pro Ser Val 
785                 790                 795                 800 


Gly Gly Ser Gly Phe Gly His Asn Tyr Arg Pro His Arg Thr Val Ser 
                805                 810                 815     


Thr Ser Ser Thr Ser Gly Asn Asp Phe Glu Glu Thr Lys Ala His Ile 
            820                 825                 830         


Arg Phe Ser Glu Ser Ala Glu Pro Leu Gly Asn Gly Glu Gln His Phe 
        835                 840                 845             


Lys Asn Gly Glu Leu Lys Leu Glu Glu Ala Ser Arg Gln Pro Cys Gly 
    850                 855                 860                 


Gln Gln Leu Ser Gly Gly Ala Ser Asp Ser Gly Arg Gly Pro Gln Arg 
865                 870                 875                 880 


Pro Asp Ala Arg Leu Leu Arg Ser Gln Ser Thr Phe Gln Leu Ser Ser 
                885                 890                 895     


Glu Pro Glu Arg Glu Pro Glu Trp Arg Asp Arg Pro Gly Ser Pro Glu 
            900                 905                 910         


Ser Pro Leu Leu Asp Ala Pro Phe Ser Arg Ala Tyr Arg Asn Ser Ile 
        915                 920                 925             


Lys Asp Ala Gln Ser Arg Val Leu Gly Ala Thr Ser Phe Arg Arg Arg 
    930                 935                 940                 


Asp Leu Glu Leu Gly Ala Pro Val Ala Ser Arg Ser Trp Arg Pro Arg 
945                 950                 955                 960 


Pro Ser Ser Ala His Val Gly Leu Arg Ser Pro Glu Ala Ser Ala Ser 
                965                 970                 975     


Ala Ser Pro His Thr Pro Arg Glu Arg His Ser Val Thr Pro Ala Glu 
            980                 985                 990         


Gly Asp Leu Ala Arg Pro Val Pro  Pro Ala Ala Arg Arg  Gly Ala Arg 
        995                 1000                 1005             


Arg Arg  Leu Thr Pro Glu Gln  Lys Lys Arg Ser Tyr  Ser Glu Pro 
    1010                 1015                 1020             


Glu Lys  Met Asn Glu Val Gly  Ile Val Glu Glu Ala  Glu Pro Ala 
    1025                 1030                 1035             


Pro Leu  Gly Pro Gln Arg Asn  Gly Met Arg Phe Pro  Glu Ser Ser 
    1040                 1045                 1050             


Val Ala  Asp Arg Arg Arg Leu  Phe Glu Arg Asp Gly  Lys Ala Cys 
    1055                 1060                 1065             


Ser Thr  Leu Ser Leu Ser Gly  Pro Glu Leu Lys Gln  Phe Gln Gln 
    1070                 1075                 1080             


Ser Ala  Leu Ala Asp Tyr Ile  Gln Arg Lys Thr Gly  Lys Arg Pro 
    1085                 1090                 1095             


Thr Ser  Ala Ala Gly Cys Ser  Leu Gln Glu Pro Gly  Pro Leu Arg 
    1100                 1105                 1110             


Glu Arg  Ala Gln Ser Ala Tyr  Leu Gln Pro Gly Pro  Ala Ala Leu 
    1115                 1120                 1125             


Glu Gly  Ser Gly Leu Ala Ser  Ala Ser Ser Leu Ser  Ser Leu Arg 
    1130                 1135                 1140             


Glu Pro  Ser Leu Gln Pro Arg  Arg Glu Ala Thr Leu  Leu Pro Ala 
    1145                 1150                 1155             


Thr Val  Ala Glu Thr Gln Gln  Ala Pro Arg Asp Arg  Ser Ser Ser 
    1160                 1165                 1170             


Phe Ala  Gly Gly Arg Arg Leu  Gly Glu Arg Arg Arg  Gly Asp Leu 
    1175                 1180                 1185             


Leu Ser  Gly Ala Asn Gly Gly  Thr Arg Gly Thr Gln  Arg Gly Asp 
    1190                 1195                 1200             


Glu Thr  Pro Arg Glu Pro Ser  Ser Trp Gly Ala Arg  Ala Gly Lys 
    1205                 1210                 1215             


Ser Met  Ser Ala Glu Asp Leu  Leu Glu Arg Ser Asp  Val Leu Ala 
    1220                 1225                 1230             


Gly Pro  Val His Val Arg Ser  Arg Ser Ser Pro Ala  Thr Ala Asp 
    1235                 1240                 1245             


Lys Arg  Gln Asp Val Leu Leu  Gly Gln Asp Ser Gly  Phe Gly Leu 
    1250                 1255                 1260             


Val Lys  Asp Pro Cys Tyr Leu  Ala Gly Pro Gly Ser  Arg Ser Leu 
    1265                 1270                 1275             


Ser Cys  Ser Glu Arg Gly Gln  Glu Glu Met Leu Pro  Leu Phe His 
    1280                 1285                 1290             


His Leu  Thr Pro Arg Trp Gly  Gly Ser Gly Cys Lys  Ala Ile Gly 
    1295                 1300                 1305             


Asp Ser  Ser Val Pro Ser Glu  Cys Pro Gly Thr Leu  Asp His Gln 
    1310                 1315                 1320             


Arg Gln  Ala Ser Arg Thr Pro  Cys Pro Arg Pro Pro  Leu Ala Gly 
    1325                 1330                 1335             


Thr Gln  Gly Leu Val Thr Asp  Thr Arg Ala Ala Pro  Leu Thr Pro 
    1340                 1345                 1350             


Ile Gly  Thr Pro Leu Pro Ser  Ala Ile Pro Ser Gly  Tyr Cys Ser 
    1355                 1360                 1365             


Gln Asp  Gly Gln Thr Gly Arg  Gln Pro Leu Pro Pro  Tyr Thr Pro 
    1370                 1375                 1380             


Ala Met  Met His Arg Ser Asn  Gly His Thr Leu Thr  Gln Pro Pro 
    1385                 1390                 1395             


Gly Pro  Arg Gly Cys Glu Gly  Asp Gly Pro Glu His  Gly Val Glu 
    1400                 1405                 1410             


Glu Gly  Thr Arg Lys Arg Val  Ser Leu Pro Gln Trp  Pro Pro Pro 
    1415                 1420                 1425             


Ser Arg  Ala Lys Trp Ala His  Ala Ala Arg Glu Asp  Ser Leu Pro 
    1430                 1435                 1440             


Glu Glu  Ser Ser Ala Pro Asp  Phe Ala Asn Leu Lys  His Tyr Gln 
    1445                 1450                 1455             


Lys Gln  Gln Ser Leu Pro Ser  Leu Cys Ser Thr Ser  Asp Pro Asp 
    1460                 1465                 1470             


Thr Pro  Leu Gly Ala Pro Ser  Thr Pro Gly Arg Ile  Ser Leu Arg 
    1475                 1480                 1485             


Ile Ser  Glu Ser Val Leu Arg  Asp Ser Pro Pro Pro  His Glu Asp 
    1490                 1495                 1500             


Tyr Glu  Asp Glu Val Phe Val  Arg Asp Pro His Pro  Lys Ala Thr 
    1505                 1510                 1515             


Ser Ser  Pro Thr Phe Glu Pro  Leu Pro Pro Pro Pro  Pro Pro Pro 
    1520                 1525                 1530             


Pro Ser  Gln Glu Thr Pro Val  Tyr Ser Met Asp Asp  Phe Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro His Thr Val Cys  Glu Ala Gln Leu Asp  Ser Glu Asp 
    1550                 1555                 1560             


Pro Glu  Gly Pro Arg Pro Ser  Phe Asn Lys Leu Ser  Lys Val Thr 
    1565                 1570                 1575             


Ile Ala  Arg Glu Arg His Met  Pro Gly Ala Ala His  Val Val Gly 
    1580                 1585                 1590             


Ser Gln  Thr Leu Ala Ser Arg  Leu Gln Thr Ser Ile  Lys Gly Ser 
    1595                 1600                 1605             


Glu Ala  Glu Ser Thr Pro Pro  Ser Phe Met Ser Val  His Ala Gln 
    1610                 1615                 1620             


Leu Ala  Gly Ser Leu Gly Gly  Gln Pro Ala Pro Ile  Gln Thr Gln 
    1625                 1630                 1635             


Ser Leu  Ser His Asp Pro Val  Ser Gly Thr Gln Gly  Leu Glu Lys 
    1640                 1645                 1650             


Lys Val  Ser Pro Asp Pro Gln  Lys Ser Ser Glu Asp  Ile Arg Thr 
    1655                 1660                 1665             


Glu Ala  Leu Ala Lys Glu Ile  Val His Gln Asp Lys  Ser Leu Ala 
    1670                 1675                 1680             


Asp Ile  Leu Asp Pro Asp Ser  Arg Leu Lys Thr Thr  Met Asp Leu 
    1685                 1690                 1695             


Met Glu  Gly Leu Phe Pro Arg  Asp Val Asn Leu Leu  Lys Glu Asn 
    1700                 1705                 1710             


Ser Val  Lys Arg Lys Ala Ile  Gln Arg Thr Val Ser  Ser Ser Gly 
    1715                 1720                 1725             


Cys Glu  Gly Lys Arg Asn Glu  Asp Lys Glu Ala Val  Ser Met Leu 
    1730                 1735                 1740             


Val Asn  Cys Pro Ala Tyr Tyr  Ser Val Ser Ala Pro  Lys Ala Glu 
    1745                 1750                 1755             


Leu Leu  Asn Lys Ile Lys Glu  Met Pro Ala Glu Val  Asn Glu Glu 
    1760                 1765                 1770             


Glu Glu  Gln Ala Asp Val Asn  Glu Lys Lys Ala Glu  Leu Ile Gly 
    1775                 1780                 1785             


Ser Leu  Thr His Lys Leu Glu  Thr Leu Gln Glu Ala  Lys Gly Ser 
    1790                 1795                 1800             


Leu Leu  Thr Asp Ile Lys Leu  Asn Asn Ala Leu Gly  Glu Glu Val 
    1805                 1810                 1815             


Glu Ala  Leu Ile Ser Glu Leu  Cys Lys Pro Asn Glu  Phe Asp Lys 
    1820                 1825                 1830             


Tyr Arg  Met Phe Ile Gly Asp  Leu Asp Lys Val Val  Asn Leu Leu 
    1835                 1840                 1845             


Leu Ser  Leu Ser Gly Arg Leu  Ala Arg Val Glu Asn  Val Leu Ser 
    1850                 1855                 1860             


Gly Leu  Gly Glu Asp Ala Ser  Asn Glu Glu Arg Ser  Ser Leu Tyr 
    1865                 1870                 1875             


Glu Lys  Arg Lys Ile Leu Ala  Gly Gln His Glu Asp  Ala Arg Glu 
    1880                 1885                 1890             


Leu Lys  Glu Asn Leu Asp Arg  Arg Glu Arg Val Val  Leu Gly Ile 
    1895                 1900                 1905             


Leu Ala  Asn Tyr Leu Ser Glu  Glu Gln Leu Gln Asp  Tyr Gln His 
    1910                 1915                 1920             


Phe Val  Lys Met Lys Ser Thr  Leu Leu Ile Glu Gln  Arg Lys Leu 
    1925                 1930                 1935             


Asp Asp  Lys Ile Lys Leu Gly  Gln Glu Gln Val Lys  Cys Leu Leu 
    1940                 1945                 1950             


Glu Ser  Leu Pro Ser Asp Phe  Ile Pro Lys Ala Gly  Ala Leu Ala 
    1955                 1960                 1965             


Leu Pro  Pro Asn Leu Thr Ser  Glu Pro Ile Pro Ala  Gly Gly Cys 
    1970                 1975                 1980             


Thr Phe  Ser Gly Ile Phe Pro  Thr Leu Thr Ser Pro  Leu 
    1985                 1990                 1995     


<210>  258
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Pro Asn Thr Ala Met Lys Lys Lys Val Leu Leu Met Gly Lys Ser 
1               5                   10                  15      


Gly Ser Gly Lys Thr Ser Met Arg Ser Ile Ile Phe Ala Asn Tyr Ile 
            20                  25                  30          


Ala Arg Asp Thr Arg Arg Leu Gly Ala Thr Ile Asp Val Glu His Ser 
        35                  40                  45              


His Val Arg Phe Leu Gly Asn Leu Val Leu Asn Leu Trp Asp Cys Gly 
    50                  55                  60                  


Gly Gln Asp Thr Phe Met Glu Asn Tyr Phe Thr Ser Gln Arg Asp Asn 
65                  70                  75                  80  


Ile Phe Arg Asn Val Glu Val Leu Ile Tyr Val Phe Asp Val Glu Ser 
                85                  90                  95      


Arg Glu Leu Glu Lys Asp Met His Tyr Tyr Gln Ser Cys Leu Glu Ala 
            100                 105                 110         


Ile Leu Gln Asn Ser Pro Asp Ala Lys Ile Phe Cys Leu Val His Lys 
        115                 120                 125             


Met Asp Leu Val Gln Glu Asp Gln Arg Asp Leu Ile Phe Lys Glu Arg 
    130                 135                 140                 


Glu Glu Asp Leu Arg Arg Leu Ser Arg Pro Leu Glu Cys Ala Cys Phe 
145                 150                 155                 160 


Arg Thr Ser Ile Trp Asp Glu Thr Leu Tyr Lys Ala Trp Ser Ser Ile 
                165                 170                 175     


Val Tyr Gln Leu Ile Pro Asn Val Gln Gln Leu Glu Met Asn Leu Arg 
            180                 185                 190         


Asn Phe Ala Gln Ile Ile Glu Ala Asp Glu Val Leu Leu Phe Glu Arg 
        195                 200                 205             


Ala Thr Phe Leu Val Ile Ser His Tyr Gln Cys Lys Glu Gln Arg Asp 
    210                 215                 220                 


Val His Arg Phe Glu Lys Ile Ser Asn Ile Ile Lys Gln Phe Lys Leu 
225                 230                 235                 240 


Ser Cys Ser Lys Leu Ala Ala Ser Phe Gln Ser Met Glu Val Arg Asn 
                245                 250                 255     


Ser Asn Phe Ala Ala Phe Ile Asp Ile Phe Thr Ser Asn Thr Tyr Val 
            260                 265                 270         


Met Val Val Met Ser Asp Pro Ser Ile Pro Ser Ala Ala Thr Leu Ile 
        275                 280                 285             


Asn Ile Arg Asn Ala Arg Lys His Phe Glu Lys Leu Glu Arg Val Asp 
    290                 295                 300                 


Gly Pro Lys His Ser Leu Leu Met Arg 
305                 310             


<210>  259
<211>  1413
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Arg His Gly Val Ala Trp Ala Leu Leu Val Ala Ala Ala Leu Gly 
1               5                   10                  15      


Leu Gly Ala Arg Gly Val Arg Gly Ala Val Ala Leu Ala Asp Phe Tyr 
            20                  25                  30          


Pro Phe Gly Ala Glu Arg Gly Asp Ala Val Thr Pro Lys Gln Asp Asp 
        35                  40                  45              


Gly Gly Ser Gly Leu Arg Pro Leu Ser Val Pro Phe Pro Phe Phe Gly 
    50                  55                  60                  


Ala Glu His Ser Gly Leu Tyr Val Asn Asn Asn Gly Ile Ile Ser Phe 
65                  70                  75                  80  


Leu Lys Glu Val Ser Gln Phe Thr Pro Val Ala Phe Pro Ile Ala Lys 
                85                  90                  95      


Asp Arg Cys Val Val Ala Ala Phe Trp Ala Asp Val Asp Asn Arg Arg 
            100                 105                 110         


Ala Gly Asp Val Tyr Tyr Arg Glu Ala Thr Asp Pro Ala Met Leu Arg 
        115                 120                 125             


Arg Ala Thr Glu Asp Val Arg His Tyr Phe Pro Glu Leu Leu Asp Phe 
    130                 135                 140                 


Asn Ala Thr Trp Val Phe Val Ala Thr Trp Tyr Arg Val Thr Phe Phe 
145                 150                 155                 160 


Gly Gly Ser Ser Ser Ser Pro Val Asn Thr Phe Gln Thr Val Leu Ile 
                165                 170                 175     


Thr Asp Gly Lys Leu Ser Phe Thr Ile Phe Asn Tyr Glu Ser Ile Val 
            180                 185                 190         


Trp Thr Thr Gly Thr His Ala Ser Ser Gly Gly Asn Ala Thr Gly Leu 
        195                 200                 205             


Gly Gly Ile Ala Ala Gln Ala Gly Phe Asn Ala Gly Asp Gly Gln Arg 
    210                 215                 220                 


Tyr Phe Ser Ile Pro Gly Ser Arg Thr Ala Asp Met Ala Glu Val Glu 
225                 230                 235                 240 


Thr Thr Thr Asn Val Gly Val Pro Gly Arg Trp Ala Phe Arg Ile Asp 
                245                 250                 255     


Asp Ala Gln Val Arg Val Gly Gly Cys Gly His Thr Thr Ser Val Cys 
            260                 265                 270         


Leu Ala Leu Arg Pro Cys Leu Asn Gly Gly Lys Cys Ile Asp Asp Cys 
        275                 280                 285             


Val Thr Gly Asn Pro Ser Tyr Thr Cys Ser Cys Leu Ser Gly Phe Thr 
    290                 295                 300                 


Gly Arg Arg Cys His Leu Asp Val Asn Glu Cys Ala Ser Gln Pro Cys 
305                 310                 315                 320 


Gln Asn Gly Gly Thr Cys Thr His Gly Ile Asn Ser Phe Arg Cys Gln 
                325                 330                 335     


Cys Pro Ala Gly Phe Gly Gly Pro Thr Cys Glu Thr Ala Gln Ser Pro 
            340                 345                 350         


Cys Asp Thr Lys Glu Cys Gln His Gly Gly Gln Cys Gln Val Glu Asn 
        355                 360                 365             


Gly Ser Ala Val Cys Val Cys Gln Ala Gly Tyr Thr Gly Ala Ala Cys 
    370                 375                 380                 


Glu Met Asp Val Asp Asp Cys Ser Pro Asp Pro Cys Leu Asn Gly Gly 
385                 390                 395                 400 


Ser Cys Val Asp Leu Val Gly Asn Tyr Thr Cys Leu Cys Ala Glu Pro 
                405                 410                 415     


Phe Lys Gly Leu Arg Cys Glu Thr Gly Asp His Pro Val Pro Asp Ala 
            420                 425                 430         


Cys Leu Ser Ala Pro Cys His Asn Gly Gly Thr Cys Val Asp Ala Asp 
        435                 440                 445             


Gln Gly Tyr Val Cys Glu Cys Pro Glu Gly Phe Met Gly Leu Asp Cys 
    450                 455                 460                 


Arg Glu Arg Val Pro Asp Asp Cys Glu Cys Arg Asn Gly Gly Arg Cys 
465                 470                 475                 480 


Leu Gly Ala Asn Thr Thr Leu Cys Gln Cys Pro Leu Gly Phe Phe Gly 
                485                 490                 495     


Leu Leu Cys Glu Phe Glu Ile Thr Ala Met Pro Cys Asn Met Asn Thr 
            500                 505                 510         


Gln Cys Pro Asp Gly Gly Tyr Cys Met Glu His Gly Gly Ser Tyr Leu 
        515                 520                 525             


Cys Val Cys His Thr Asp His Asn Ala Ser His Ser Leu Pro Ser Pro 
    530                 535                 540                 


Cys Asp Ser Asp Pro Cys Phe Asn Gly Gly Ser Cys Asp Ala His Asp 
545                 550                 555                 560 


Asp Ser Tyr Thr Cys Glu Cys Pro Arg Gly Phe His Gly Lys His Cys 
                565                 570                 575     


Glu Lys Ala Arg Pro His Leu Cys Ser Ser Gly Pro Cys Arg Asn Gly 
            580                 585                 590         


Gly Thr Cys Lys Glu Ala Gly Gly Glu Tyr His Cys Ser Cys Pro Tyr 
        595                 600                 605             


Arg Phe Thr Gly Arg His Cys Glu Ile Gly Lys Pro Asp Ser Cys Ala 
    610                 615                 620                 


Ser Gly Pro Cys His Asn Gly Gly Thr Cys Phe His Tyr Ile Gly Lys 
625                 630                 635                 640 


Tyr Lys Cys Asp Cys Pro Pro Gly Phe Ser Gly Arg His Cys Glu Ile 
                645                 650                 655     


Ala Pro Ser Pro Cys Phe Arg Ser Pro Cys Val Asn Gly Gly Thr Cys 
            660                 665                 670         


Glu Asp Arg Asp Thr Asp Phe Phe Cys His Cys Gln Ala Gly Tyr Met 
        675                 680                 685             


Gly Arg Arg Cys Gln Ala Glu Val Asp Cys Gly Pro Pro Glu Glu Val 
    690                 695                 700                 


Lys His Ala Thr Leu Arg Phe Asn Gly Thr Arg Leu Gly Ala Val Ala 
705                 710                 715                 720 


Leu Tyr Ala Cys Asp Arg Gly Tyr Ser Leu Ser Ala Pro Ser Arg Ile 
                725                 730                 735     


Arg Val Cys Gln Pro His Gly Val Trp Ser Glu Pro Pro Gln Cys Leu 
            740                 745                 750         


Glu Ile Asp Glu Cys Arg Ser Gln Pro Cys Leu His Gly Gly Ser Cys 
        755                 760                 765             


Gln Asp Arg Val Ala Gly Tyr Leu Cys Leu Cys Ser Thr Gly Tyr Glu 
    770                 775                 780                 


Gly Ala His Cys Glu Leu Glu Arg Asp Glu Cys Arg Ala His Pro Cys 
785                 790                 795                 800 


Arg Asn Gly Gly Ser Cys Arg Asn Leu Pro Gly Ala Tyr Val Cys Arg 
                805                 810                 815     


Cys Pro Ala Gly Phe Val Gly Val His Cys Glu Thr Glu Val Asp Ala 
            820                 825                 830         


Cys Asp Ser Ser Pro Cys Gln His Gly Gly Arg Cys Glu Ser Gly Gly 
        835                 840                 845             


Gly Ala Tyr Leu Cys Val Cys Pro Glu Ser Phe Phe Gly Tyr His Cys 
    850                 855                 860                 


Glu Thr Val Ser Asp Pro Cys Phe Ser Ser Pro Cys Gly Gly Arg Gly 
865                 870                 875                 880 


Tyr Cys Leu Ala Ser Asn Gly Ser His Ser Cys Thr Cys Lys Val Gly 
                885                 890                 895     


Tyr Thr Gly Glu Asp Cys Ala Lys Glu Leu Phe Pro Pro Thr Ala Leu 
            900                 905                 910         


Lys Met Glu Arg Val Glu Glu Ser Gly Val Ser Ile Ser Trp Asn Pro 
        915                 920                 925             


Pro Asn Gly Pro Ala Ala Arg Gln Met Leu Asp Gly Tyr Ala Val Thr 
    930                 935                 940                 


Tyr Val Ser Ser Asp Gly Ser Tyr Arg Arg Thr Asp Phe Val Asp Arg 
945                 950                 955                 960 


Thr Arg Ser Ser His Gln Leu Gln Ala Leu Ala Ala Gly Arg Ala Tyr 
                965                 970                 975     


Asn Ile Ser Val Phe Ser Val Lys Arg Asn Ser Asn Asn Lys Asn Asp 
            980                 985                 990         


Ile Ser Arg Pro Ala Val Leu Leu  Ala Arg Thr Arg Pro  Arg Pro Val 
        995                 1000                 1005             


Glu Gly  Phe Glu Val Thr Asn  Val Thr Ala Ser Thr  Ile Ser Val 
    1010                 1015                 1020             


Gln Trp  Ala Leu His Arg Ile  Arg His Ala Thr Val  Ser Gly Val 
    1025                 1030                 1035             


Arg Val  Ser Ile Arg His Pro  Glu Ala Leu Arg Asp  Gln Ala Thr 
    1040                 1045                 1050             


Asp Val  Asp Arg Ser Val Asp  Arg Phe Thr Phe Arg  Ala Leu Leu 
    1055                 1060                 1065             


Pro Gly  Lys Arg Tyr Thr Ile  Gln Leu Thr Thr Leu  Ser Gly Leu 
    1070                 1075                 1080             


Arg Gly  Glu Glu His Pro Thr  Glu Ser Leu Ala Thr  Ala Pro Thr 
    1085                 1090                 1095             


His Val  Trp Thr Arg Pro Leu  Pro Pro Ala Asn Leu  Thr Ala Ala 
    1100                 1105                 1110             


Arg Val  Thr Ala Thr Ser Ala  His Val Val Trp Asp  Ala Pro Thr 
    1115                 1120                 1125             


Pro Gly  Ser Leu Leu Glu Ala  Tyr Val Ile Asn Val  Thr Thr Ser 
    1130                 1135                 1140             


Gln Ser  Thr Lys Ser Arg Tyr  Val Pro Asn Gly Lys  Leu Ala Ser 
    1145                 1150                 1155             


Tyr Thr  Val Arg Asp Leu Leu  Pro Gly Arg Arg Tyr  Gln Leu Ser 
    1160                 1165                 1170             


Val Ile  Ala Val Gln Ser Thr  Glu Leu Gly Pro Gln  His Ser Glu 
    1175                 1180                 1185             


Pro Ala  His Leu Tyr Ile Ile  Thr Ser Pro Arg Asp  Gly Ala Asp 
    1190                 1195                 1200             


Arg Arg  Trp His Gln Gly Gly  His His Pro Arg Val  Leu Lys Asn 
    1205                 1210                 1215             


Arg Pro  Pro Pro Ala Arg Leu  Pro Glu Leu Arg Leu  Leu Asn Asp 
    1220                 1225                 1230             


His Ser  Ala Pro Glu Thr Pro  Thr Gln Pro Pro Arg  Phe Ser Glu 
    1235                 1240                 1245             


Leu Val  Asp Gly Arg Gly Arg  Val Ser Ala Arg Phe  Gly Gly Ser 
    1250                 1255                 1260             


Pro Ser  Lys Ala Ala Thr Val  Arg Ser Gln Pro Thr  Ala Ser Ala 
    1265                 1270                 1275             


Gln Leu  Glu Asn Met Glu Glu  Ala Pro Lys Arg Val  Ser Leu Ala 
    1280                 1285                 1290             


Leu Gln  Leu Pro Glu His Gly  Ser Lys Asp Ile Gly  Asn Val Pro 
    1295                 1300                 1305             


Gly Asn  Cys Ser Glu Asn Pro  Cys Gln Asn Gly Gly  Thr Cys Val 
    1310                 1315                 1320             


Pro Gly  Ala Asp Ala His Ser  Cys Asp Cys Gly Pro  Gly Phe Lys 
    1325                 1330                 1335             


Gly Arg  Arg Cys Glu Leu Ala  Cys Ile Lys Val Ser  Arg Pro Cys 
    1340                 1345                 1350             


Thr Arg  Leu Phe Ser Glu Thr  Lys Ala Phe Pro Val  Trp Glu Gly 
    1355                 1360                 1365             


Gly Val  Cys His His Val Tyr  Lys Arg Val Tyr Arg  Val His Gln 
    1370                 1375                 1380             


Asp Ile  Cys Phe Lys Glu Ser  Cys Glu Ser Thr Ser  Leu Lys Lys 
    1385                 1390                 1395             


Thr Pro  Asn Arg Lys Gln Ser  Lys Ser Gln Thr Leu  Glu Lys Ser 
    1400                 1405                 1410             


<210>  260
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Lys Trp Val Trp Ala Leu Leu Leu Leu Ala Ala Leu Gly Ser Gly 
1               5                   10                  15      


Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
            20                  25                  30          


Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys 
        35                  40                  45              


Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser 
    50                  55                  60                  


Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
65                  70                  75                  80  


Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                85                  90                  95      


Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
            100                 105                 110         


Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp 
        115                 120                 125             


Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp 
    130                 135                 140                 


Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
145                 150                 155                 160 


Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu 
                165                 170                 175     


Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys 
            180                 185                 190         


Asp Gly Arg Ser Glu Arg Asn Leu Leu 
        195                 200     


<210>  261
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  262
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Thr His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly Lys 
1               5                   10                  15      


Ala Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala 
            20                  25                  30          


Ala Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg Val 
        35                  40                  45              


Phe Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp His 
    50                  55                  60                  


Ile Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly 
65                  70                  75                  80  


Gly Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu 
                85                  90                  95      


Gly Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr Asn 
            100                 105                 110         


Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe 
        115                 120                 125             


Arg Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly Lys 
    130                 135                 140                 


Ile Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val Gly 
145                 150                 155                 160 


Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile 
                165                 170                 175     


Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala Ile 
            180                 185                 190         


Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met 
        195                 200                 205             


Gly Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu 
225                 230                 235                 240 


Glu His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg 
                245                 250                 255     


Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys 
            260                 265                 270         


Pro Ile Thr Ser Glu Asp Ile Lys Asn Leu Val Val Lys Arg Leu Gly 
        275                 280                 285             


Tyr Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr 
    290                 295                 300                 


Pro Ser Ala Phe Asp Arg Ile Leu Gly Ser Arg Met Gly Val Glu Ala 
305                 310                 315                 320 


Val Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val Val 
                325                 330                 335     


Ser Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu Cys Val 
            340                 345                 350         


Gln Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys Phe Asp 
        355                 360                 365             


Glu Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu Val 
    370                 375                 380                 


Tyr Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser Gly Ser 
385                 390                 395                 400 


His Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met Asn 
                405                 410                 415     


Ala Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn Arg 
            420                 425                 430         


Val Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Ile 
        435                 440                 445             


Glu Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly Gly 
    450                 455                 460                 


Ser Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe Glu Gln 
465                 470                 475                 480 


Ile Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val Ile Ile 
                485                 490                 495     


Gly Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly Arg 
            500                 505                 510         


Lys Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala Thr 
        515                 520                 525             


Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala Asp Thr 
    530                 535                 540                 


Ala Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser Ala 
545                 550                 555                 560 


Ala Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly Tyr 
                565                 570                 575     


Cys Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp Ala 
            580                 585                 590         


Ala Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Ala Asn 
        595                 600                 605             


Val Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly Leu 
    610                 615                 620                 


Val Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile 
625                 630                 635                 640 


Phe Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg Lys 
                645                 650                 655     


Asn Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro Phe Asp 
            660                 665                 670         


Arg Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp Met Ser 
        675                 680                 685             


Gly Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn Thr 
    690                 695                 700                 


Pro Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val Phe 
705                 710                 715                 720 


Gln Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg Ile 
                725                 730                 735     


Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile Leu 
            740                 745                 750         


Ala Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu Glu 
        755                 760                 765             


His Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val 
    770                 775                 780 


<210>  263
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Thr His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly Lys 
1               5                   10                  15      


Ala Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala 
            20                  25                  30          


Ala Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg Val 
        35                  40                  45              


Phe Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp His 
    50                  55                  60                  


Ile Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly 
65                  70                  75                  80  


Gly Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu 
                85                  90                  95      


Gly Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr Asn 
            100                 105                 110         


Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe 
        115                 120                 125             


Arg Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly Lys 
    130                 135                 140                 


Ile Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val Gly 
145                 150                 155                 160 


Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile 
                165                 170                 175     


Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala Ile 
            180                 185                 190         


Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met 
        195                 200                 205             


Gly Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu 
225                 230                 235                 240 


Glu His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg 
                245                 250                 255     


Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys 
            260                 265                 270         


Pro Ile Thr Ser Glu Asp Ile Lys Asn Gly Ser Arg Met Gly Val Glu 
        275                 280                 285             


Ala Val Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val 
    290                 295                 300                 


Val Ser Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu Cys 
305                 310                 315                 320 


Val Gln Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys Phe 
                325                 330                 335     


Asp Glu Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu 
            340                 345                 350         


Val Tyr Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser Gly 
        355                 360                 365             


Ser His Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met 
    370                 375                 380                 


Asn Ala Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn 
385                 390                 395                 400 


Arg Val Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln 
                405                 410                 415     


Ile Glu Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly 
            420                 425                 430         


Gly Ser Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe Glu 
        435                 440                 445             


Gln Ile Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val Ile 
    450                 455                 460                 


Ile Gly Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly 
465                 470                 475                 480 


Arg Lys Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala 
                485                 490                 495     


Thr Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala Asp 
            500                 505                 510         


Thr Ala Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser 
        515                 520                 525             


Ala Ala Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly 
    530                 535                 540                 


Tyr Cys Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp 
545                 550                 555                 560 


Ala Ala Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Ala 
                565                 570                 575     


Asn Val Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly 
            580                 585                 590         


Leu Val Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe 
        595                 600                 605             


Ile Phe Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg 
    610                 615                 620                 


Lys Asn Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro Phe 
625                 630                 635                 640 


Asp Arg Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp Met 
                645                 650                 655     


Ser Gly Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn 
            660                 665                 670         


Thr Pro Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val 
        675                 680                 685             


Phe Gln Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg 
    690                 695                 700                 


Ile Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile 
705                 710                 715                 720 


Leu Ala Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu 
                725                 730                 735     


Glu His Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val 
            740                 745                 


<210>  264
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Glu Glu Lys Leu Lys Lys Thr Lys Ile Ile Phe Val Val Gly Gly 
1               5                   10                  15      


Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Ile Val Gln Lys Tyr 
            20                  25                  30          


Gly Tyr Thr His Leu Ser Thr Gly Asp Leu Leu Arg Ser Glu Val Ser 
        35                  40                  45              


Ser Gly Ser Ala Arg Gly Lys Lys Leu Ser Glu Ile Met Glu Lys Gly 
    50                  55                  60                  


Gln Leu Val Pro Leu Glu Thr Val Leu Asp Met Leu Arg Asp Ala Met 
65                  70                  75                  80  


Val Ala Lys Val Asn Thr Ser Lys Gly Phe Leu Ile Asp Gly Tyr Pro 
                85                  90                  95      


Arg Glu Val Gln Gln Gly Glu Glu Phe Glu Arg Arg Ile Gly Gln Pro 
            100                 105                 110         


Thr Leu Leu Leu Tyr Val Asp Ala Gly Pro Glu Thr Met Thr Gln Arg 
        115                 120                 125             


Leu Leu Lys Arg Gly Glu Thr Ser Gly Arg Val Asp Asp Asn Glu Glu 
    130                 135                 140                 


Thr Ile Lys Lys Arg Leu Glu Thr Tyr Tyr Lys Ala Thr Glu Pro Val 
145                 150                 155                 160 


Ile Ala Phe Tyr Glu Lys Arg Gly Ile Val Arg Lys Val Asn Ala Glu 
                165                 170                 175     


Gly Ser Val Asp Ser Val Phe Ser Gln Val Cys Thr His Leu Asp Ala 
            180                 185                 190         


Leu Lys 
        


<210>  265
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Asn Gln Ile Glu Pro Gly Val Gln Tyr Asn Tyr Val Tyr Asp Glu 
1               5                   10                  15      


Asp Glu Tyr Met Ile Gln Glu Glu Glu Trp Asp Arg Asp Leu Leu Leu 
            20                  25                  30          


Asp Pro Ala Trp Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys 
        35                  40                  45              


Asn Ser His Leu Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Glu Glu 
    50                  55                  60                  


Asp Phe Arg Asn Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser 
65                  70                  75                  80  


Gly Glu Arg Leu Pro Lys Pro Asp Arg Gly Lys Met Arg Phe His Lys 
                85                  90                  95      


Ile Ala Asn Val Asn Lys Ala Leu Asp Tyr Ile Ala Ser Lys Gly Val 
            100                 105                 110         


Lys Leu Val Ser Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Val Lys 
        115                 120                 125             


Met Thr Leu Gly Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln 
    130                 135                 140                 


Asp Ile Ser Val Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp 
145                 150                 155                 160 


Cys Gln Arg Lys Thr Ala Pro Tyr Arg Asn Val Asn Ile Gln Asn Phe 
                165                 170                 175     


His Thr Ser Trp Lys Asp Gly Leu Gly Leu Cys Ala Leu Ile His Arg 
            180                 185                 190         


His Arg Pro Asp Leu Ile Asp Tyr Ser Lys Leu Asn Lys Asp Asp Pro 
        195                 200                 205             


Ile Gly Asn Ile Asn Leu Ala Met Glu Ile Ala Glu Lys His Leu Asp 
    210                 215                 220                 


Ile Pro Lys Met Leu Asp Ala Glu Asp Ile Val Asn Thr Pro Lys Pro 
225                 230                 235                 240 


Asp Glu Arg Ala Ile Met Thr Tyr Val Ser Cys Phe Tyr His Ala Phe 
                245                 250                 255     


Ala Gly Ala Glu Gln Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val 
            260                 265                 270         


Leu Ala Val Asn Gln Glu Asn Glu Arg Leu Met Glu Glu Tyr Glu Arg 
        275                 280                 285             


Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu 
    290                 295                 300                 


Glu Asn Arg Thr Pro Glu Lys Thr Met Gln Ala Met Gln Lys Lys Leu 
305                 310                 315                 320 


Glu Asp Phe Arg Asp Tyr Arg Arg Lys His Lys Pro Pro Lys Val Gln 
                325                 330                 335     


Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu 
            340                 345                 350         


Arg Ile Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val 
        355                 360                 365             


Ser Asp Ile Ala Gly Ala Trp Gln Arg Leu Glu Gln Ala Glu Lys Gly 
    370                 375                 380                 


Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Glu 
385                 390                 395                 400 


His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Thr His Glu Thr Trp 
                405                 410                 415     


Ala Tyr Gly Lys Glu Gln Ile Leu Leu Gln Lys Asp Tyr Glu Ser Ala 
            420                 425                 430         


Ser Leu Thr Glu Val Arg Ala Leu Leu Arg Lys His Glu Ala Phe Glu 
        435                 440                 445             


Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile 
    450                 455                 460                 


Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Asp Ala Val Asn Val Asn 
465                 470                 475                 480 


Asp Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Arg Leu Gly Thr Leu 
                485                 490                 495     


Thr Gln Lys Arg Arg Glu Ala Leu Glu Arg Met Glu Lys Leu Leu Glu 
            500                 505                 510         


Thr Ile Asp Gln Leu His Leu Glu Phe Ala Lys Arg Ala Ala Pro Phe 
        515                 520                 525             


Asn Asn Trp Met Glu Gly Ala Met Glu Asp Leu Gln Asp Met Phe Ile 
    530                 535                 540                 


Val His Ser Ile Glu Glu Ile Gln Ser Leu Ile Thr Ala His Glu Gln 
545                 550                 555                 560 


Phe Lys Ala Thr Leu Pro Glu Ala Asp Gly Glu Arg Gln Ser Ile Met 
                565                 570                 575     


Ala Ile Gln Asn Glu Val Glu Lys Val Ile Gln Ser Tyr Asn Ile Arg 
            580                 585                 590         


Ile Ser Ser Ser Asn Pro Tyr Ser Thr Val Thr Met Asp Glu Leu Arg 
        595                 600                 605             


Thr Lys Trp Asp Lys Val Lys Gln Leu Val Pro Ile Arg Asp Gln Ser 
    610                 615                 620                 


Leu Gln Glu Glu Leu Ala Arg Gln His Ala Asn Glu Arg Leu Arg Arg 
625                 630                 635                 640 


Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln Asn Lys 
                645                 650                 655     


Met Glu Glu Ile Ala Arg Ser Ser Ile Gln Ile Thr Gly Ala Leu Glu 
            660                 665                 670         


Asp Gln Met Asn Gln Leu Lys Gln Tyr Glu His Asn Ile Ile Asn Tyr 
        675                 680                 685             


Lys Asn Asn Ile Asp Lys Leu Glu Gly Asp His Gln Leu Ile Gln Glu 
    690                 695                 700                 


Ala Leu Val Phe Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile 
705                 710                 715                 720 


Arg Val Gly Trp Glu Leu Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn 
                725                 730                 735     


Glu Val Glu Thr Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Thr Gln 
            740                 745                 750         


Glu Gln Met Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Arg 
        755                 760                 765             


Lys Asn Gly Leu Met Asp His Glu Asp Phe Arg Ala Cys Leu Ile Ser 
    770                 775                 780                 


Met Gly Tyr Asp Leu Gly Glu Ala Glu Phe Ala Arg Ile Met Thr Leu 
785                 790                 795                 800 


Val Asp Pro Asn Gly Gln Gly Thr Val Thr Phe Gln Ser Phe Ile Asp 
                805                 810                 815     


Phe Met Thr Arg Glu Thr Ala Asp Thr Asp Thr Ala Glu Gln Val Ile 
            820                 825                 830         


Ala Ser Phe Arg Ile Leu Ala Ser Asp Lys Pro Tyr Ile Leu Ala Glu 
        835                 840                 845             


Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Gln Tyr Cys Ile Lys 
    850                 855                 860                 


Arg Met Pro Ala Tyr Ser Gly Pro Gly Ser Val Pro Gly Ala Leu Asp 
865                 870                 875                 880 


Tyr Ala Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890                 


<210>  266
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Ser Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Ala Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  267
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Ser Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Ala Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val 
145                 150                 155                 160 


Tyr His His Leu Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala 
                165                 170                 175     


Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn 
            180                 185                 190         


Asn Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr 
        195                 200                 205             


Pro Asp Lys Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr 
    210                 215                 220                 


Arg Asn Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala 
225                 230                 235                 240 


Arg His Ile Thr Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile 
                245                 250                 255     


Lys Asn Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp 
            260                 265                 270         


Trp Ala Thr Trp Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val 
        275                 280                 285             


Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val 
    290                 295                 300                 


Glu Lys Lys Ala Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly 
305                 310                 315                 320 


Ser Val Thr Glu Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly 
                325                 330                 335     


Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe 
            340                 345                 350         


Ile Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly 
        355                 360                 365             


Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg 
    370                 375                 380                 


Ile Glu Glu Ala Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe 
385                 390                 395                 400 


Arg Asn Pro Lys Ala Lys 
                405     


<210>  268
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Ala Lys Phe Gly 
    50                  55                  60                  


Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala 
65                  70                  75                  80  


Ala Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly 
                85                  90                  95      


Asn Pro Asp Leu Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly 
            100                 105                 110         


Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu 
        115                 120                 125             


Pro Val Gly Ala Ser Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu 
    130                 135                 140                 


Val Tyr His His Leu Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp 
145                 150                 155                 160 


Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu 
                165                 170                 175     


Asn Asn Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly 
            180                 185                 190         


Tyr Pro Asp Lys Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe 
        195                 200                 205             


Tyr Arg Asn Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Arg His Ile Thr Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe 
225                 230                 235                 240 


Ile Lys Asn Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp 
                245                 250                 255     


Asp Trp Ala Thr Trp Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile 
            260                 265                 270         


Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala 
        275                 280                 285             


Val Glu Lys Lys Ala Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile 
    290                 295                 300                 


Gly Ser Val Thr Glu Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn 
305                 310                 315                 320 


Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr 
                325                 330                 335     


Phe Ile Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr 
            340                 345                 350         


Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met 
        355                 360                 365             


Arg Ile Glu Glu Ala Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys 
    370                 375                 380                 


Phe Arg Asn Pro Lys Ala Lys 
385                 390     


<210>  269
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro 
1               5                   10                  15      


Glu Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Leu Glu Leu Tyr Lys Lys Leu Arg Asp Lys Glu Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Val Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Glu Leu Phe Asp Pro Ile Ile Ser Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His 
            100                 105                 110         


Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu 
145                 150                 155                 160 


Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Lys Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly 
                245                 250                 255     


Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met 
            260                 265                 270         


Trp Asn Gln His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala His Leu Ser Lys 
    290                 295                 300                 


His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ser Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu 
        355                 360                 365             


Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys 
    370                 375                 380     


<210>  270
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  271
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Ser Arg Pro Leu Ser Asp Gln Glu Lys Arg Lys Gln Ile Ser Val 
1               5                   10                  15      


Arg Gly Leu Ala Gly Val Glu Asn Val Thr Glu Leu Lys Lys Asn Phe 
            20                  25                  30          


Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
        35                  40                  45              


Pro Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
    50                  55                  60                  


Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Lys Asp Pro 
65                  70                  75                  80  


Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                85                  90                  95      


Gln Asn Thr Met Val Asn Leu Ala Leu Glu Asn Ala Cys Asp Glu Ala 
            100                 105                 110         


Thr Tyr Gln Leu Gly Leu Asp Met Glu Glu Leu Glu Glu Ile Glu Glu 
        115                 120                 125             


Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
    130                 135                 140                 


Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
145                 150                 155                 160 


Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Ser Gly Gly Trp Gln 
                165                 170                 175     


Met Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
            180                 185                 190         


Ala Arg Pro Glu Phe Thr Leu Pro Val His Phe Tyr Gly His Val Glu 
        195                 200                 205             


His Thr Ser Gln Gly Ala Lys Trp Val Asp Thr Gln Val Val Leu Ala 
    210                 215                 220                 


Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Arg Asn Asn Val Val Asn 
225                 230                 235                 240 


Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Asn Leu Lys 
                245                 250                 255     


Asp Phe Asn Val Gly Gly Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu 
            260                 265                 270         


Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
        275                 280                 285             


Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
    290                 295                 300                 


Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
305                 310                 315                 320 


Asp Pro Val Arg Thr Asn Phe Asp Ala Phe Pro Asp Lys Val Ala Ile 
                325                 330                 335     


Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro Glu Leu Met Arg 
            340                 345                 350         


Ile Leu Val Asp Leu Glu Arg Met Asp Trp Asp Lys Ala Trp Asp Val 
        355                 360                 365             


Thr Val Arg Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
    370                 375                 380                 


Leu Glu Arg Trp Pro Val His Leu Leu Glu Thr Leu Leu Pro Arg His 
385                 390                 395                 400 


Leu Gln Ile Ile Tyr Glu Ile Asn Gln Arg Phe Leu Asn Arg Val Ala 
                405                 410                 415     


Ala Ala Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Leu Val 
            420                 425                 430         


Glu Glu Gly Ala Val Lys Arg Ile Asn Met Ala His Leu Cys Ile Ala 
        435                 440                 445             


Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Leu 
    450                 455                 460                 


Lys Lys Thr Ile Phe Lys Asp Phe Tyr Glu Leu Glu Pro His Lys Phe 
465                 470                 475                 480 


Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Val Leu Cys 
                485                 490                 495     


Asn Pro Gly Leu Ala Glu Val Ile Ala Glu Arg Ile Gly Glu Asp Phe 
            500                 505                 510         


Ile Ser Asp Leu Asp Gln Leu Arg Lys Leu Leu Ser Phe Val Asp Asp 
        515                 520                 525             


Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
    530                 535                 540                 


Lys Phe Ala Ala Tyr Leu Glu Arg Glu Tyr Lys Val His Ile Asn Pro 
545                 550                 555                 560 


Asn Ser Leu Phe Asp Ile Gln Val Lys Arg Ile His Glu Tyr Lys Arg 
                565                 570                 575     


Gln Leu Leu Asn Cys Leu His Val Ile Thr Leu Tyr Asn Arg Ile Lys 
            580                 585                 590         


Arg Glu Pro Asn Lys Phe Phe Val Pro Arg Thr Val Met Ile Gly Gly 
        595                 600                 605             


Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Arg Leu Val 
    610                 615                 620                 


Thr Ala Ile Gly Asp Val Val Asn His Asp Pro Ala Val Gly Asp Arg 
625                 630                 635                 640 


Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                645                 650                 655     


Val Ile Pro Ala Ala Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly Thr 
            660                 665                 670         


Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
        675                 680                 685             


Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
    690                 695                 700                 


Gly Glu Glu Asn Phe Phe Ile Phe Gly Met Arg Val Glu Asp Val Asp 
705                 710                 715                 720 


Lys Leu Asp Gln Arg Gly Tyr Asn Ala Gln Glu Tyr Tyr Asp Arg Ile 
                725                 730                 735     


Pro Glu Leu Arg Gln Val Ile Glu Gln Leu Ser Ser Gly Phe Phe Ser 
            740                 745                 750         


Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Val Asn Met Leu Met His 
        755                 760                 765             


His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Asp Tyr Ile Lys Cys 
    770                 775                 780                 


Gln Glu Lys Val Ser Ala Leu Tyr Lys Asn Pro Arg Glu Trp Thr Arg 
785                 790                 795                 800 


Met Val Ile Arg Asn Ile Ala Thr Ser Gly Lys Phe Ser Ser Asp Arg 
                805                 810                 815     


Thr Ile Ala Gln Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Arg 
            820                 825                 830         


Gln Arg Leu Pro Ala Pro Asp Glu Ala Ile 
        835                 840         


<210>  272
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210>  273
<211>  1939
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Ser Ser Asp Ser Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Phe 
1               5                   10                  15      


Leu Arg Lys Ser Glu Arg Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Ser Val Phe Val Val Asp Pro Lys Glu Ser Phe Val 
        35                  40                  45              


Lys Ala Thr Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gly Ala Thr Val Thr Val Lys Asp Asp Gln Val Phe Pro Met 
65                  70                  75                  80  


Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His 
                85                  90                  95      


Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Thr Ala Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu 
        195                 200                 205             


Glu Val Thr Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Met Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Glu Ile Leu Gly Phe Thr Ser Asp Glu Arg Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Asn Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Asp Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Pro 
                565                 570                 575     


Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn 
            580                 585                 590         


Ile Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Leu Leu Phe 
    610                 615                 620                 


Val Gly Ala Thr Gly Ala Glu Ala Glu Ala Gly Gly Gly Lys Lys Gly 
625                 630                 635                 640 


Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg 
                645                 650                 655     


Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His 
            660                 665                 670         


Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met 
        675                 680                 685             


Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu 
    690                 695                 700                 


Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala 
705                 710                 715                 720 


Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu 
                725                 730                 735     


Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser 
            740                 745                 750         


Ile Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe 
        755                 760                 765             


Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys 
    770                 775                 780                 


Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Met Cys Arg Gly Phe Leu 
785                 790                 795                 800 


Ala Arg Val Glu Tyr Gln Lys Met Val Glu Arg Arg Glu Ser Ile Phe 
                805                 810                 815     


Cys Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro 
            820                 825                 830         


Trp Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu 
        835                 840                 845             


Thr Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys 
    850                 855                 860                 


Glu Glu Leu Ala Lys Thr Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys 
865                 870                 875                 880 


Met Val Thr Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln 
                885                 890                 895     


Ala Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu 
            900                 905                 910         


Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu 
        915                 920                 925             


Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys 
    930                 935                 940                 


Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp 
945                 950                 955                 960 


Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu 
                965                 970                 975     


Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr 
            980                 985                 990         


Ile Ala Lys Leu Thr Lys Glu Lys  Lys Ala Leu Gln Glu  Ala His Gln 
        995                 1000                 1005             


Gln Thr  Leu Asp Asp Leu Gln  Ala Glu Glu Asp Lys  Val Asn Thr 
    1010                 1015                 1020             


Leu Thr  Lys Ala Lys Ile Lys  Leu Glu Gln Gln Val  Asp Asp Leu 
    1025                 1030                 1035             


Glu Gly  Ser Leu Glu Gln Glu  Lys Lys Ile Arg Met  Asp Leu Glu 
    1040                 1045                 1050             


Arg Ala  Lys Arg Lys Leu Glu  Gly Asp Leu Lys Leu  Ala Gln Glu 
    1055                 1060                 1065             


Ser Thr  Met Asp Ile Glu Asn  Asp Lys Gln Gln Leu  Asp Glu Lys 
    1070                 1075                 1080             


Leu Lys  Lys Lys Glu Phe Glu  Met Ser Gly Leu Gln  Ser Lys Ile 
    1085                 1090                 1095             


Glu Asp  Glu Gln Ala Leu Gly  Met Gln Leu Gln Lys  Lys Ile Lys 
    1100                 1105                 1110             


Glu Leu  Gln Ala Arg Ile Glu  Glu Leu Glu Glu Glu  Ile Glu Ala 
    1115                 1120                 1125             


Glu Arg  Ala Ser Arg Ala Lys  Ala Glu Lys Gln Arg  Ser Asp Leu 
    1130                 1135                 1140             


Ser Arg  Glu Leu Glu Glu Ile  Ser Glu Arg Leu Glu  Glu Ala Gly 
    1145                 1150                 1155             


Gly Ala  Thr Ser Ala Gln Ile  Glu Met Asn Lys Lys  Arg Glu Ala 
    1160                 1165                 1170             


Glu Phe  Gln Lys Met Arg Arg  Asp Leu Glu Glu Ala  Thr Leu Gln 
    1175                 1180                 1185             


His Glu  Ala Thr Ala Ala Thr  Leu Arg Lys Lys His  Ala Asp Ser 
    1190                 1195                 1200             


Val Ala  Glu Leu Gly Glu Gln  Ile Asp Asn Leu Gln  Arg Val Lys 
    1205                 1210                 1215             


Gln Lys  Leu Glu Lys Glu Lys  Ser Glu Met Lys Met  Glu Ile Asp 
    1220                 1225                 1230             


Asp Leu  Ala Ser Asn Met Glu  Thr Val Ser Lys Ala  Lys Gly Asn 
    1235                 1240                 1245             


Leu Glu  Lys Met Cys Arg Ala  Leu Glu Asp Gln Leu  Ser Glu Ile 
    1250                 1255                 1260             


Lys Thr  Lys Glu Glu Glu Gln  Gln Arg Leu Ile Asn  Asp Leu Thr 
    1265                 1270                 1275             


Ala Gln  Arg Ala Arg Leu Gln  Thr Glu Ser Gly Glu  Tyr Ser Arg 
    1280                 1285                 1290             


Gln Leu  Asp Glu Lys Asp Thr  Leu Val Ser Gln Leu  Ser Arg Gly 
    1295                 1300                 1305             


Lys Gln  Ala Phe Thr Gln Gln  Ile Glu Glu Leu Lys  Arg Gln Leu 
    1310                 1315                 1320             


Glu Glu  Glu Ile Lys Ala Lys  Ser Ala Leu Ala His  Ala Leu Gln 
    1325                 1330                 1335             


Ser Ser  Arg His Asp Cys Asp  Leu Leu Arg Glu Gln  Tyr Glu Glu 
    1340                 1345                 1350             


Glu Gln  Glu Ala Lys Ala Glu  Leu Gln Arg Ala Met  Ser Lys Ala 
    1355                 1360                 1365             


Asn Ser  Glu Val Ala Gln Trp  Arg Thr Lys Tyr Glu  Thr Asp Ala 
    1370                 1375                 1380             


Ile Gln  Arg Thr Glu Glu Leu  Glu Glu Ala Lys Lys  Lys Leu Ala 
    1385                 1390                 1395             


Gln Arg  Leu Gln Asp Ala Glu  Glu His Val Glu Ala  Val Asn Ala 
    1400                 1405                 1410             


Lys Cys  Ala Ser Leu Glu Lys  Thr Lys Gln Arg Leu  Gln Asn Glu 
    1415                 1420                 1425             


Val Glu  Asp Leu Met Ile Asp  Val Glu Arg Thr Asn  Ala Ala Cys 
    1430                 1435                 1440             


Ala Ala  Leu Asp Lys Lys Gln  Arg Asn Phe Asp Lys  Ile Leu Ala 
    1445                 1450                 1455             


Glu Trp  Lys Gln Lys Cys Glu  Glu Thr His Ala Glu  Leu Glu Ala 
    1460                 1465                 1470             


Ser Gln  Lys Glu Ser Arg Ser  Leu Ser Thr Glu Leu  Phe Lys Ile 
    1475                 1480                 1485             


Lys Asn  Ala Tyr Glu Glu Ser  Leu Asp Gln Leu Glu  Thr Leu Lys 
    1490                 1495                 1500             


Arg Glu  Asn Lys Asn Leu Gln  Gln Glu Ile Ser Asp  Leu Thr Glu 
    1505                 1510                 1515             


Gln Ile  Ala Glu Gly Gly Lys  Arg Ile His Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Lys Lys  Gln Val Glu Gln Glu  Lys Ser Glu Leu Gln  Ala Ala Leu 
    1535                 1540                 1545             


Glu Glu  Ala Glu Ala Ser Leu  Glu His Glu Glu Gly  Lys Ile Leu 
    1550                 1555                 1560             


Arg Ile  Gln Leu Glu Leu Asn  Gln Val Lys Ser Glu  Val Asp Arg 
    1565                 1570                 1575             


Lys Ile  Ala Glu Lys Asp Glu  Glu Ile Asp Gln Met  Lys Arg Asn 
    1580                 1585                 1590             


His Ile  Arg Ile Val Glu Ser  Met Gln Ser Thr Leu  Asp Ala Glu 
    1595                 1600                 1605             


Ile Arg  Ser Arg Asn Asp Ala  Ile Arg Leu Lys Lys  Lys Met Glu 
    1610                 1615                 1620             


Gly Asp  Leu Asn Glu Met Glu  Ile Gln Leu Asn His  Ala Asn Arg 
    1625                 1630                 1635             


Met Ala  Ala Glu Ala Leu Arg  Asn Tyr Arg Asn Thr  Gln Ala Ile 
    1640                 1645                 1650             


Leu Lys  Asp Thr Gln Leu His  Leu Asp Asp Ala Leu  Arg Ser Gln 
    1655                 1660                 1665             


Glu Asp  Leu Lys Glu Gln Leu  Ala Met Val Glu Arg  Arg Ala Asn 
    1670                 1675                 1680             


Leu Leu  Gln Ala Glu Ile Glu  Glu Leu Arg Ala Thr  Leu Glu Gln 
    1685                 1690                 1695             


Thr Glu  Arg Ser Arg Lys Ile  Ala Glu Gln Glu Leu  Leu Asp Ala 
    1700                 1705                 1710             


Ser Glu  Arg Val Gln Leu Leu  His Thr Gln Asn Thr  Ser Leu Ile 
    1715                 1720                 1725             


Asn Thr  Lys Lys Lys Leu Glu  Thr Asp Ile Ser Gln  Ile Gln Gly 
    1730                 1735                 1740             


Glu Met  Glu Asp Ile Ile Gln  Glu Ala Arg Asn Ala  Glu Glu Lys 
    1745                 1750                 1755             


Ala Lys  Lys Ala Ile Thr Asp  Ala Ala Met Met Ala  Glu Glu Leu 
    1760                 1765                 1770             


Lys Lys  Glu Gln Asp Thr Ser  Ala His Leu Glu Arg  Met Lys Lys 
    1775                 1780                 1785             


Asn Leu  Glu Gln Thr Val Lys  Asp Leu Gln His Arg  Leu Asp Glu 
    1790                 1795                 1800             


Ala Glu  Gln Leu Ala Leu Lys  Gly Gly Lys Lys Gln  Ile Gln Lys 
    1805                 1810                 1815             


Leu Glu  Ala Arg Val Arg Glu  Leu Glu Gly Glu Val  Glu Ser Glu 
    1820                 1825                 1830             


Gln Lys  Arg Asn Val Glu Ala  Val Lys Gly Leu Arg  Lys His Glu 
    1835                 1840                 1845             


Arg Lys  Val Lys Glu Leu Thr  Tyr Gln Thr Glu Glu  Asp Arg Lys 
    1850                 1855                 1860             


Asn Ile  Leu Arg Leu Gln Asp  Leu Val Asp Lys Leu  Gln Ala Lys 
    1865                 1870                 1875             


Val Lys  Ser Tyr Lys Arg Gln  Ala Glu Glu Ala Glu  Glu Gln Ser 
    1880                 1885                 1890             


Asn Val  Asn Leu Ser Lys Phe  Arg Arg Ile Gln His  Glu Leu Glu 
    1895                 1900                 1905             


Glu Ala  Glu Glu Arg Ala Asp  Ile Ala Glu Ser Gln  Val Asn Lys 
    1910                 1915                 1920             


Leu Arg  Val Lys Ser Arg Glu  Val His Thr Lys Ile  Ile Ser Glu 
    1925                 1930                 1935             


Glu 
    


<210>  274
<211>  1941
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Ser Ser Asp Ser Glu Leu Ala Val Phe Gly Glu Ala Ala Pro Phe 
1               5                   10                  15      


Leu Arg Lys Ser Glu Arg Glu Arg Ile Glu Ala Gln Asn Arg Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Ser Val Phe Val Ala Glu Pro Lys Glu Ser Phe Val 
        35                  40                  45              


Lys Gly Thr Ile Gln Ser Arg Glu Gly Gly Lys Val Thr Val Lys Thr 
    50                  55                  60                  


Glu Gly Gly Ala Thr Leu Thr Val Lys Asp Asp Gln Val Phe Pro Met 
65                  70                  75                  80  


Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His 
                85                  90                  95      


Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Thr Ala Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu 
        195                 200                 205             


Glu Ile Thr Ser Gly Lys Ile Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Val Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Thr Ser Asn Lys Lys Pro Glu Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Pro Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Ser Val Ala Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Asp Ile Leu Gly Phe Thr Asn Glu Glu Lys Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Leu Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Ser Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Glu Gln Val Ser Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Glu Lys Met Phe Leu Trp Met Val Ala Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Ala Asn Phe Gln Lys Pro Lys Val Val Lys Gly Lys Ala 
                565                 570                 575     


Glu Ala His Phe Ala Leu Ile His Tyr Ala Gly Val Val Asp Tyr Asn 
            580                 585                 590         


Ile Thr Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Gln Leu Phe 
    610                 615                 620                 


Ser Gly Ala Gln Thr Ala Glu Gly Glu Gly Ala Gly Gly Gly Ala Lys 
625                 630                 635                 640 


Lys Gly Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu 
                645                 650                 655     


Phe Arg Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His 
            660                 665                 670         


Pro His Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly 
        675                 680                 685             


Ala Met Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val 
    690                 695                 700                 


Leu Glu Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu 
705                 710                 715                 720 


Tyr Ala Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile 
                725                 730                 735     


Pro Glu Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu 
            740                 745                 750         


Ala Ser Ile Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys 
        755                 760                 765             


Val Phe Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp 
    770                 775                 780                 


Asp Lys Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Arg Cys Arg Gly 
785                 790                 795                 800 


Phe Leu Ala Arg Val Glu Tyr Gln Arg Met Val Glu Arg Arg Glu Ala 
                805                 810                 815     


Ile Phe Cys Ile Gln Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His 
            820                 825                 830         


Trp Pro Trp Met Lys Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser 
        835                 840                 845             


Ala Glu Thr Glu Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys 
    850                 855                 860                 


Ile Lys Asp Glu Leu Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu 
865                 870                 875                 880 


Glu Lys Met Val Thr Leu Leu Lys Glu Lys Asn Asp Leu Gln Leu Gln 
                885                 890                 895     


Val Gln Ala Glu Ala Glu Gly Leu Ala Asp Ala Glu Glu Arg Cys Asp 
            900                 905                 910         


Gln Leu Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val 
        915                 920                 925             


Thr Glu Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala 
    930                 935                 940                 


Lys Lys Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile 
945                 950                 955                 960 


Asp Asp Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala 
                965                 970                 975     


Thr Glu Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp 
            980                 985                 990         


Glu Thr Ile Ala Lys Leu Thr Lys  Glu Lys Lys Ala Leu  Gln Glu Ala 
        995                 1000                 1005             


His Gln  Gln Thr Leu Asp Asp  Leu Gln Ala Glu Glu  Asp Lys Val 
    1010                 1015                 1020             


Asn Thr  Leu Thr Lys Ala Lys  Ile Lys Leu Glu Gln  Gln Val Asp 
    1025                 1030                 1035             


Asp Leu  Glu Gly Ser Leu Glu  Gln Glu Lys Lys Leu  Arg Met Asp 
    1040                 1045                 1050             


Leu Glu  Arg Ala Lys Arg Lys  Leu Glu Gly Asp Leu  Lys Leu Ala 
    1055                 1060                 1065             


Gln Glu  Ser Ile Met Asp Ile  Glu Asn Glu Lys Gln  Gln Leu Asp 
    1070                 1075                 1080             


Glu Lys  Leu Lys Lys Lys Glu  Phe Glu Ile Ser Asn  Leu Gln Ser 
    1085                 1090                 1095             


Lys Ile  Glu Asp Glu Gln Ala  Leu Gly Ile Gln Leu  Gln Lys Lys 
    1100                 1105                 1110             


Ile Lys  Glu Leu Gln Ala Arg  Ile Glu Glu Leu Glu  Glu Glu Ile 
    1115                 1120                 1125             


Glu Ala  Glu Arg Ala Ser Arg  Ala Lys Ala Glu Lys  Gln Arg Ser 
    1130                 1135                 1140             


Asp Leu  Ser Arg Glu Leu Glu  Glu Ile Ser Glu Arg  Leu Glu Glu 
    1145                 1150                 1155             


Ala Gly  Gly Ala Thr Ser Ala  Gln Ile Glu Met Asn  Lys Lys Arg 
    1160                 1165                 1170             


Glu Ala  Glu Phe Gln Lys Met  Arg Arg Asp Leu Glu  Glu Ala Thr 
    1175                 1180                 1185             


Leu Gln  His Glu Ala Thr Ala  Ala Thr Leu Arg Lys  Lys His Ala 
    1190                 1195                 1200             


Asp Ser  Val Ala Glu Leu Gly  Glu Gln Ile Asp Asn  Leu Gln Arg 
    1205                 1210                 1215             


Val Lys  Gln Lys Leu Glu Lys  Glu Lys Ser Glu Met  Lys Met Glu 
    1220                 1225                 1230             


Ile Asp  Asp Leu Ala Ser Asn  Val Glu Thr Val Ser  Lys Ala Lys 
    1235                 1240                 1245             


Gly Asn  Leu Glu Lys Met Cys  Arg Thr Leu Glu Asp  Gln Leu Ser 
    1250                 1255                 1260             


Glu Leu  Lys Ser Lys Glu Glu  Glu Gln Gln Arg Leu  Ile Asn Asp 
    1265                 1270                 1275             


Leu Thr  Ala Gln Arg Gly Arg  Leu Gln Thr Glu Ser  Gly Glu Phe 
    1280                 1285                 1290             


Ser Arg  Gln Leu Asp Glu Lys  Glu Ala Leu Val Ser  Gln Leu Ser 
    1295                 1300                 1305             


Arg Gly  Lys Gln Ala Phe Thr  Gln Gln Ile Glu Glu  Leu Lys Arg 
    1310                 1315                 1320             


Gln Leu  Glu Glu Glu Ile Lys  Ala Lys Asn Ala Leu  Ala His Ala 
    1325                 1330                 1335             


Leu Gln  Ser Ser Arg His Asp  Cys Asp Leu Leu Arg  Glu Gln Tyr 
    1340                 1345                 1350             


Glu Glu  Glu Gln Glu Ser Lys  Ala Glu Leu Gln Arg  Ala Leu Ser 
    1355                 1360                 1365             


Lys Ala  Asn Thr Glu Val Ala  Gln Trp Arg Thr Lys  Tyr Glu Thr 
    1370                 1375                 1380             


Asp Ala  Ile Gln Arg Thr Glu  Glu Leu Glu Glu Ala  Lys Lys Lys 
    1385                 1390                 1395             


Leu Ala  Gln Arg Leu Gln Ala  Ala Glu Glu His Val  Glu Ala Val 
    1400                 1405                 1410             


Asn Ala  Lys Cys Ala Ser Leu  Glu Lys Thr Lys Gln  Arg Leu Gln 
    1415                 1420                 1425             


Asn Glu  Val Glu Asp Leu Met  Leu Asp Val Glu Arg  Thr Asn Ala 
    1430                 1435                 1440             


Ala Cys  Ala Ala Leu Asp Lys  Lys Gln Arg Asn Phe  Asp Lys Ile 
    1445                 1450                 1455             


Leu Ala  Glu Trp Lys Gln Lys  Cys Glu Glu Thr His  Ala Glu Leu 
    1460                 1465                 1470             


Glu Ala  Ser Gln Lys Glu Ala  Arg Ser Leu Gly Thr  Glu Leu Phe 
    1475                 1480                 1485             


Lys Ile  Lys Asn Ala Tyr Glu  Glu Ser Leu Asp Gln  Leu Glu Thr 
    1490                 1495                 1500             


Leu Lys  Arg Glu Asn Lys Asn  Leu Gln Gln Glu Ile  Ser Asp Leu 
    1505                 1510                 1515             


Thr Glu  Gln Ile Ala Glu Gly  Gly Lys Arg Ile His  Glu Leu Glu 
    1520                 1525                 1530             


Lys Ile  Lys Lys Gln Val Glu  Gln Glu Lys Cys Glu  Leu Gln Ala 
    1535                 1540                 1545             


Ala Leu  Glu Glu Ala Glu Ala  Ser Leu Glu His Glu  Glu Gly Lys 
    1550                 1555                 1560             


Ile Leu  Arg Ile Gln Leu Glu  Leu Asn Gln Val Lys  Ser Glu Val 
    1565                 1570                 1575             


Asp Arg  Lys Ile Ala Glu Lys  Asp Glu Glu Ile Asp  Gln Leu Lys 
    1580                 1585                 1590             


Arg Asn  His Ile Arg Ile Val  Glu Ser Met Gln Ser  Thr Leu Asp 
    1595                 1600                 1605             


Ala Glu  Ile Arg Ser Arg Asn  Asp Ala Ile Arg Leu  Lys Lys Lys 
    1610                 1615                 1620             


Met Glu  Gly Asp Leu Asn Glu  Met Glu Ile Gln Leu  Asn His Ala 
    1625                 1630                 1635             


Asn Arg  Met Ala Ala Glu Ala  Leu Arg Asn Tyr Arg  Asn Thr Gln 
    1640                 1645                 1650             


Gly Ile  Leu Lys Asp Thr Gln  Ile His Leu Asp Asp  Ala Leu Arg 
    1655                 1660                 1665             


Ser Gln  Glu Asp Leu Lys Glu  Gln Leu Ala Met Val  Glu Arg Arg 
    1670                 1675                 1680             


Ala Asn  Leu Leu Gln Ala Glu  Ile Glu Glu Leu Arg  Ala Thr Leu 
    1685                 1690                 1695             


Glu Gln  Thr Glu Arg Ser Arg  Lys Ile Ala Glu Gln  Glu Leu Leu 
    1700                 1705                 1710             


Asp Ala  Ser Glu Arg Val Gln  Leu Leu His Thr Gln  Asn Thr Ser 
    1715                 1720                 1725             


Leu Ile  Asn Thr Lys Lys Lys  Leu Glu Thr Asp Ile  Ser Gln Met 
    1730                 1735                 1740             


Gln Gly  Glu Met Glu Asp Ile  Leu Gln Glu Ala Arg  Asn Ala Glu 
    1745                 1750                 1755             


Glu Lys  Ala Lys Lys Ala Ile  Thr Asp Ala Ala Met  Met Ala Glu 
    1760                 1765                 1770             


Glu Leu  Lys Lys Glu Gln Asp  Thr Ser Ala His Leu  Glu Arg Met 
    1775                 1780                 1785             


Lys Lys  Asn Met Glu Gln Thr  Val Lys Asp Leu Gln  Leu Arg Leu 
    1790                 1795                 1800             


Asp Glu  Ala Glu Gln Leu Ala  Leu Lys Gly Gly Lys  Lys Gln Ile 
    1805                 1810                 1815             


Gln Lys  Leu Glu Ala Arg Val  Arg Glu Leu Glu Gly  Glu Val Glu 
    1820                 1825                 1830             


Ser Glu  Gln Lys Arg Asn Ala  Glu Ala Val Lys Gly  Leu Arg Lys 
    1835                 1840                 1845             


His Glu  Arg Arg Val Lys Glu  Leu Thr Tyr Gln Thr  Glu Glu Asp 
    1850                 1855                 1860             


Arg Lys  Asn Ile Leu Arg Leu  Gln Asp Leu Val Asp  Lys Leu Gln 
    1865                 1870                 1875             


Ala Lys  Val Lys Ser Tyr Lys  Arg Gln Ala Glu Glu  Ala Glu Glu 
    1880                 1885                 1890             


Gln Ser  Asn Thr Asn Leu Ala  Lys Phe Arg Lys Leu  Gln His Glu 
    1895                 1900                 1905             


Leu Glu  Glu Ala Glu Glu Arg  Ala Asp Ile Ala Glu  Ser Gln Val 
    1910                 1915                 1920             


Asn Lys  Leu Arg Val Lys Ser  Arg Glu Val His Thr  Lys Val Ile 
    1925                 1930                 1935             


Ser Glu  Glu 
    1940     


<210>  275
<211>  1940
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Ser Ser Asp Thr Glu Met Glu Val Phe Gly Ile Ala Ala Pro Phe 
1               5                   10                  15      


Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Gln Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Tyr Cys Phe Val Val Asp Ser Lys Glu Glu Tyr Ala 
        35                  40                  45              


Lys Gly Lys Ile Lys Ser Ser Gln Asp Gly Lys Val Thr Val Glu Thr 
    50                  55                  60                  


Glu Asp Asn Arg Thr Leu Val Val Lys Pro Glu Asp Val Tyr Ala Met 
65                  70                  75                  80  


Asn Pro Pro Lys Phe Asp Arg Ile Glu Asp Met Ala Met Leu Thr His 
                85                  90                  95      


Leu Asn Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Thr Ser 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Asn Pro Glu Val Val Glu Gly Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Ala Thr Gly Asp Leu Ala Lys Lys 
        195                 200                 205             


Lys Asp Ser Lys Met Lys Gly Thr Leu Glu Asp Gln Ile Ile Ser Ala 
    210                 215                 220                 


Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp 
225                 230                 235                 240 


Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Thr Thr 
                245                 250                 255     


Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser 
            260                 265                 270         


Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile Phe Tyr 
        275                 280                 285             


Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Ile Glu Leu Leu Leu Ile 
    290                 295                 300                 


Thr Thr Asn Pro Tyr Asp Tyr Pro Phe Ile Ser Gln Gly Glu Ile Leu 
305                 310                 315                 320 


Val Ala Ser Ile Asp Asp Ala Glu Glu Leu Leu Ala Thr Asp Ser Ala 
                325                 330                 335     


Ile Asp Ile Leu Gly Phe Thr Pro Glu Glu Lys Ser Gly Leu Tyr Lys 
            340                 345                 350         


Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys 
        355                 360                 365             


Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala Asp Lys 
    370                 375                 380                 


Thr Ala Tyr Leu Met Gly Leu Asn Ser Ser Asp Leu Leu Lys Ala Leu 
385                 390                 395                 400 


Cys Phe Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln 
                405                 410                 415     


Thr Val Asp Gln Val His His Ala Val Asn Ala Leu Ser Lys Ser Val 
            420                 425                 430         


Tyr Glu Lys Leu Phe Leu Trp Met Val Thr Arg Ile Asn Gln Gln Leu 
        435                 440                 445             


Asp Thr Lys Leu Pro Arg Gln His Phe Ile Gly Val Leu Asp Ile Ala 
    450                 455                 460                 


Gly Phe Glu Ile Phe Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn 
465                 470                 475                 480 


Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val 
                485                 490                 495     


Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile 
            500                 505                 510         


Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu Lys Pro 
        515                 520                 525             


Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala 
    530                 535                 540                 


Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu Gly Lys 
545                 550                 555                 560 


Ser Asn Asn Phe Gln Lys Pro Lys Val Val Lys Gly Arg Ala Glu Ala 
                565                 570                 575     


His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Ser Val Ser 
            580                 585                 590         


Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly 
        595                 600                 605             


Leu Tyr Gln Lys Ser Ser Asn Arg Leu Leu Ala His Leu Tyr Ala Thr 
    610                 615                 620                 


Phe Ala Thr Ala Asp Ala Asp Ser Gly Lys Lys Lys Val Ala Lys Lys 
625                 630                 635                 640 


Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu Asn Leu 
                645                 650                 655     


Asn Lys Leu Met Ser Asn Leu Arg Thr Thr His Pro His Phe Val Arg 
            660                 665                 670         


Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu His Ser 
        675                 680                 685             


Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg 
    690                 695                 700                 


Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Lys 
705                 710                 715                 720 


Gln Arg Tyr Arg Val Leu Asn Ala Ser Ala Ile Pro Glu Gly Gln Phe 
                725                 730                 735     


Ile Asp Ser Lys Lys Ala Cys Glu Lys Leu Leu Ala Ser Ile Asp Ile 
            740                 745                 750         


Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala 
        755                 760                 765             


Gly Leu Leu Gly Thr Leu Glu Glu Met Arg Asp Asp Arg Leu Ala Lys 
    770                 775                 780                 


Leu Ile Thr Arg Thr Gln Ala Val Cys Arg Gly Phe Leu Met Arg Val 
785                 790                 795                 800 


Glu Phe Gln Lys Met Val Gln Arg Arg Glu Ser Ile Phe Cys Ile Gln 
                805                 810                 815     


Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His Trp Pro Trp Met Lys 
            820                 825                 830         


Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu Lys 
        835                 840                 845             


Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys Thr Lys Asp Glu Leu 
    850                 855                 860                 


Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Leu Val Thr 
865                 870                 875                 880 


Leu Val Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Ser 
                885                 890                 895     


Glu Asn Leu Leu Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Ala 
            900                 905                 910         


Lys Phe Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu Arg Ala Glu 
        915                 920                 925             


Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu 
    930                 935                 940                 


Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu Leu 
945                 950                 955                 960 


Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val 
                965                 970                 975     


Lys Asn Leu Thr Glu Glu Leu Ser Gly Leu Asp Glu Thr Ile Ala Lys 
            980                 985                 990         


Leu Thr Arg Glu Lys Lys Ala Leu  Gln Glu Ala His Gln  Gln Ala Leu 
        995                 1000                 1005             


Asp Asp  Leu Gln Ala Glu Glu  Asp Lys Val Asn Ser  Leu Asn Lys 
    1010                 1015                 1020             


Thr Lys  Ser Lys Leu Glu Gln  Gln Val Glu Asp Leu  Glu Ser Ser 
    1025                 1030                 1035             


Leu Glu  Gln Glu Lys Lys Leu  Arg Val Asp Leu Glu  Arg Asn Lys 
    1040                 1045                 1050             


Arg Lys  Leu Glu Gly Asp Leu  Lys Leu Ala Gln Glu  Ser Ile Leu 
    1055                 1060                 1065             


Asp Leu  Glu Asn Asp Lys Gln  Gln Leu Asp Glu Arg  Leu Lys Lys 
    1070                 1075                 1080             


Lys Asp  Phe Glu Tyr Cys Gln  Leu Gln Ser Lys Val  Glu Asp Glu 
    1085                 1090                 1095             


Gln Thr  Leu Gly Leu Gln Phe  Gln Lys Lys Ile Lys  Glu Leu Gln 
    1100                 1105                 1110             


Ala Arg  Ile Glu Glu Leu Glu  Glu Glu Ile Glu Ala  Glu Arg Ala 
    1115                 1120                 1125             


Thr Arg  Ala Lys Thr Glu Lys  Gln Arg Ser Asp Tyr  Ala Arg Glu 
    1130                 1135                 1140             


Leu Glu  Glu Leu Ser Glu Arg  Leu Glu Glu Ala Gly  Gly Val Thr 
    1145                 1150                 1155             


Ser Thr  Gln Ile Glu Leu Asn  Lys Lys Arg Glu Ala  Glu Phe Leu 
    1160                 1165                 1170             


Lys Leu  Arg Arg Asp Leu Glu  Glu Ala Thr Leu Gln  His Glu Ala 
    1175                 1180                 1185             


Met Val  Ala Ala Leu Arg Lys  Lys His Ala Asp Ser  Val Ala Glu 
    1190                 1195                 1200             


Leu Gly  Glu Gln Ile Asp Asn  Leu Gln Arg Val Lys  Gln Lys Leu 
    1205                 1210                 1215             


Glu Lys  Glu Lys Ser Glu Phe  Lys Leu Glu Ile Asp  Asp Leu Ser 
    1220                 1225                 1230             


Ser Ser  Met Glu Ser Val Ser  Lys Ser Lys Ala Asn  Leu Glu Lys 
    1235                 1240                 1245             


Ile Cys  Arg Thr Leu Glu Asp  Gln Leu Ser Glu Ala  Arg Gly Lys 
    1250                 1255                 1260             


Asn Glu  Glu Ile Gln Arg Ser  Leu Ser Glu Leu Thr  Thr Gln Lys 
    1265                 1270                 1275             


Ser Arg  Leu Gln Thr Glu Ala  Gly Glu Leu Ser Arg  Gln Leu Glu 
    1280                 1285                 1290             


Glu Lys  Glu Ser Ile Val Ser  Gln Leu Ser Arg Ser  Lys Gln Ala 
    1295                 1300                 1305             


Phe Thr  Gln Gln Thr Glu Glu  Leu Lys Arg Gln Leu  Glu Glu Glu 
    1310                 1315                 1320             


Asn Lys  Ala Lys Asn Ala Leu  Ala His Ala Leu Gln  Ser Ser Arg 
    1325                 1330                 1335             


His Asp  Cys Asp Leu Leu Arg  Glu Gln Tyr Glu Glu  Glu Gln Glu 
    1340                 1345                 1350             


Gly Lys  Ala Glu Leu Gln Arg  Ala Leu Ser Lys Ala  Asn Ser Glu 
    1355                 1360                 1365             


Val Ala  Gln Trp Arg Thr Lys  Tyr Glu Thr Asp Ala  Ile Gln Arg 
    1370                 1375                 1380             


Thr Glu  Glu Leu Glu Glu Ala  Lys Lys Lys Leu Ala  Gln Arg Leu 
    1385                 1390                 1395             


Gln Asp  Ser Glu Glu Gln Val  Glu Ala Val Asn Ala  Lys Cys Ala 
    1400                 1405                 1410             


Ser Leu  Glu Lys Thr Lys Gln  Arg Leu Gln Gly Glu  Val Glu Asp 
    1415                 1420                 1425             


Leu Met  Val Asp Val Glu Arg  Ala Asn Ser Leu Ala  Ala Ala Leu 
    1430                 1435                 1440             


Asp Lys  Lys Gln Arg Asn Phe  Asp Lys Val Leu Ala  Glu Trp Lys 
    1445                 1450                 1455             


Thr Lys  Cys Glu Glu Ser Gln  Ala Glu Leu Glu Ala  Ser Leu Lys 
    1460                 1465                 1470             


Glu Ser  Arg Ser Leu Ser Thr  Glu Leu Phe Lys Leu  Lys Asn Ala 
    1475                 1480                 1485             


Tyr Glu  Glu Ala Leu Asp Gln  Leu Glu Thr Val Lys  Arg Glu Asn 
    1490                 1495                 1500             


Lys Asn  Leu Glu Gln Glu Ile  Ala Asp Leu Thr Glu  Gln Ile Ala 
    1505                 1510                 1515             


Glu Asn  Gly Lys Thr Ile His  Glu Leu Glu Lys Ser  Arg Lys Gln 
    1520                 1525                 1530             


Ile Glu  Leu Glu Lys Ala Asp  Ile Gln Leu Ala Leu  Glu Glu Ala 
    1535                 1540                 1545             


Glu Ala  Ala Leu Glu His Glu  Glu Ala Lys Ile Leu  Arg Ile Gln 
    1550                 1555                 1560             


Leu Glu  Leu Thr Gln Val Lys  Ser Glu Ile Asp Arg  Lys Ile Ala 
    1565                 1570                 1575             


Glu Lys  Asp Glu Glu Ile Glu  Gln Leu Lys Arg Asn  Tyr Gln Arg 
    1580                 1585                 1590             


Thr Val  Glu Thr Met Gln Ser  Ala Leu Asp Ala Glu  Val Arg Ser 
    1595                 1600                 1605             


Arg Asn  Glu Ala Ile Arg Leu  Lys Lys Lys Met Glu  Gly Asp Leu 
    1610                 1615                 1620             


Asn Glu  Ile Glu Ile Gln Leu  Ser His Ala Asn Arg  Gln Ala Ala 
    1625                 1630                 1635             


Glu Thr  Leu Lys His Leu Arg  Ser Val Gln Gly Gln  Leu Lys Asp 
    1640                 1645                 1650             


Thr Gln  Leu His Leu Asp Asp  Ala Leu Arg Gly Gln  Glu Asp Leu 
    1655                 1660                 1665             


Lys Glu  Gln Leu Ala Ile Val  Glu Arg Arg Ala Asn  Leu Leu Gln 
    1670                 1675                 1680             


Ala Glu  Val Glu Glu Leu Arg  Ala Thr Leu Glu Gln  Thr Glu Arg 
    1685                 1690                 1695             


Ala Arg  Lys Leu Ala Glu Gln  Glu Leu Leu Asp Ser  Asn Glu Arg 
    1700                 1705                 1710             


Val Gln  Leu Leu His Thr Gln  Asn Thr Ser Leu Ile  His Thr Lys 
    1715                 1720                 1725             


Lys Lys  Leu Glu Thr Asp Leu  Met Gln Leu Gln Ser  Glu Val Glu 
    1730                 1735                 1740             


Asp Ala  Ser Arg Asp Ala Arg  Asn Ala Glu Glu Lys  Ala Lys Lys 
    1745                 1750                 1755             


Ala Ile  Thr Asp Ala Ala Met  Met Ala Glu Glu Leu  Lys Lys Glu 
    1760                 1765                 1770             


Gln Asp  Thr Ser Ala His Leu  Glu Arg Met Lys Lys  Asn Leu Glu 
    1775                 1780                 1785             


Gln Thr  Val Lys Asp Leu Gln  His Arg Leu Asp Glu  Ala Glu Gln 
    1790                 1795                 1800             


Leu Ala  Leu Lys Gly Gly Lys  Lys Gln Ile Gln Lys  Leu Glu Thr 
    1805                 1810                 1815             


Arg Ile  Arg Glu Leu Glu Phe  Glu Leu Glu Gly Glu  Gln Lys Lys 
    1820                 1825                 1830             


Asn Thr  Glu Ser Val Lys Gly  Leu Arg Lys Tyr Glu  Arg Arg Val 
    1835                 1840                 1845             


Lys Glu  Leu Thr Tyr Gln Ser  Glu Glu Asp Arg Lys  Asn Val Leu 
    1850                 1855                 1860             


Arg Leu  Gln Asp Leu Val Asp  Lys Leu Gln Val Lys  Val Lys Ser 
    1865                 1870                 1875             


Tyr Lys  Arg Gln Ala Glu Glu  Ala Asp Glu Gln Ala  Asn Ala His 
    1880                 1885                 1890             


Leu Thr  Lys Phe Arg Lys Ala  Gln His Glu Leu Glu  Glu Ala Glu 
    1895                 1900                 1905             


Glu Arg  Ala Asp Ile Ala Glu  Ser Gln Val Asn Lys  Leu Arg Ala 
    1910                 1915                 1920             


Lys Thr  Arg Asp Phe Thr Ser  Ser Arg Met Val Val  His Glu Ser 
    1925                 1930                 1935             


Glu Glu  
    1940 


<210>  276
<211>  1939
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Ser Ser Asp Ser Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Phe 
1               5                   10                  15      


Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Ser Val Phe Val Val Asp Pro Lys Glu Ser Tyr Val 
        35                  40                  45              


Lys Ala Ile Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gly Ala Thr Val Thr Val Lys Glu Asp Gln Val Phe Ser Met 
65                  70                  75                  80  


Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His 
                85                  90                  95      


Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Asn Pro Glu Val Val Thr Ala Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu 
        195                 200                 205             


Glu Pro Ala Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Ala Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Phe Ala Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Val Asp Ile Leu Gly Phe Thr Ala Asp Glu Lys Val Ala Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Thr Ser Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ser Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Phe Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Ile Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Pro 
                565                 570                 575     


Glu Ala His Phe Ser Leu Val His Tyr Ala Gly Thr Val Asp Tyr Asn 
            580                 585                 590         


Ile Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Phe Leu Phe 
    610                 615                 620                 


Ser Gly Ala Gln Thr Ala Glu Ala Glu Gly Gly Gly Gly Lys Lys Gly 
625                 630                 635                 640 


Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg 
                645                 650                 655     


Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His 
            660                 665                 670         


Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met 
        675                 680                 685             


Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu 
    690                 695                 700                 


Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala 
705                 710                 715                 720 


Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu 
                725                 730                 735     


Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser 
            740                 745                 750         


Ile Glu Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe 
        755                 760                 765             


Phe Lys Ala Gly Leu Leu Gly Thr Leu Glu Glu Met Arg Asp Glu Lys 
    770                 775                 780                 


Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Ile Cys Arg Gly Phe Leu 
785                 790                 795                 800 


Met Arg Val Glu Phe Arg Lys Met Met Glu Arg Arg Glu Ser Ile Phe 
                805                 810                 815     


Cys Ile Gln Tyr Asn Ile Arg Ala Phe Met Asn Val Lys His Trp Pro 
            820                 825                 830         


Trp Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu 
        835                 840                 845             


Thr Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys 
    850                 855                 860                 


Glu Glu Leu Ala Lys Thr Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys 
865                 870                 875                 880 


Met Val Thr Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln 
                885                 890                 895     


Ala Glu Ala Asp Ala Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu 
            900                 905                 910         


Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu 
        915                 920                 925             


Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys 
    930                 935                 940                 


Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp 
945                 950                 955                 960 


Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu 
                965                 970                 975     


Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr 
            980                 985                 990         


Ile Ala Lys Leu Thr Lys Glu Lys  Lys Ala Leu Gln Glu  Ala His Gln 
        995                 1000                 1005             


Gln Thr  Leu Asp Asp Leu Gln  Met Glu Glu Asp Lys  Val Asn Thr 
    1010                 1015                 1020             


Leu Thr  Lys Ala Lys Thr Lys  Leu Glu Gln Gln Val  Asp Asp Leu 
    1025                 1030                 1035             


Glu Gly  Ser Leu Glu Gln Glu  Lys Lys Leu Cys Met  Asp Leu Glu 
    1040                 1045                 1050             


Arg Ala  Lys Arg Lys Leu Glu  Gly Asp Leu Lys Leu  Ala Gln Glu 
    1055                 1060                 1065             


Ser Thr  Met Asp Thr Glu Asn  Asp Lys Gln Gln Leu  Asn Glu Lys 
    1070                 1075                 1080             


Leu Lys  Lys Lys Glu Phe Glu  Met Ser Asn Leu Gln  Gly Lys Ile 
    1085                 1090                 1095             


Glu Asp  Glu Gln Ala Leu Ala  Ile Gln Leu Gln Lys  Lys Ile Lys 
    1100                 1105                 1110             


Glu Leu  Gln Ala Arg Ile Glu  Glu Leu Glu Glu Glu  Ile Glu Ala 
    1115                 1120                 1125             


Glu Arg  Ala Ser Arg Ala Lys  Ala Glu Lys Gln Arg  Ser Asp Leu 
    1130                 1135                 1140             


Ser Arg  Glu Leu Glu Glu Ile  Ser Glu Arg Leu Glu  Glu Ala Gly 
    1145                 1150                 1155             


Gly Ala  Thr Ser Ala Gln Ile  Glu Met Asn Lys Lys  Arg Glu Ala 
    1160                 1165                 1170             


Glu Phe  Gln Lys Met Arg Arg  Asp Leu Glu Glu Ser  Thr Leu Gln 
    1175                 1180                 1185             


His Glu  Ala Thr Ala Ala Ala  Leu Arg Lys Lys His  Ala Asp Ser 
    1190                 1195                 1200             


Val Ala  Glu Leu Gly Glu Gln  Ile Asp Ser Leu Gln  Arg Val Lys 
    1205                 1210                 1215             


Gln Lys  Leu Glu Lys Glu Lys  Ser Glu Leu Lys Met  Glu Ile Asn 
    1220                 1225                 1230             


Asp Leu  Ala Ser Asn Met Glu  Thr Val Ser Lys Ala  Lys Ala Asn 
    1235                 1240                 1245             


Phe Glu  Lys Met Cys Arg Thr  Leu Glu Asp Gln Leu  Ser Glu Ile 
    1250                 1255                 1260             


Lys Thr  Lys Glu Glu Glu Gln  Gln Arg Leu Ile Asn  Glu Leu Ser 
    1265                 1270                 1275             


Ala Gln  Lys Ala Arg Leu His  Thr Glu Ser Gly Glu  Phe Ser Arg 
    1280                 1285                 1290             


Gln Leu  Asp Glu Lys Asp Ala  Met Val Ser Gln Leu  Ser Arg Gly 
    1295                 1300                 1305             


Lys Gln  Ala Phe Thr Gln Gln  Ile Glu Glu Leu Lys  Arg Gln Leu 
    1310                 1315                 1320             


Glu Glu  Glu Thr Lys Ala Lys  Ser Thr Leu Ala His  Ala Leu Gln 
    1325                 1330                 1335             


Ser Ala  Arg His Asp Cys Asp  Leu Leu Arg Glu Gln  Tyr Glu Glu 
    1340                 1345                 1350             


Glu Gln  Glu Ala Lys Ala Glu  Leu Gln Arg Gly Met  Ser Lys Ala 
    1355                 1360                 1365             


Asn Ser  Glu Val Ala Gln Trp  Arg Thr Lys Tyr Glu  Thr Asp Ala 
    1370                 1375                 1380             


Ile Gln  Arg Thr Glu Glu Leu  Glu Glu Ala Lys Lys  Lys Leu Ala 
    1385                 1390                 1395             


Gln Arg  Leu Gln Asp Ala Glu  Glu His Val Glu Ala  Val Asn Ser 
    1400                 1405                 1410             


Lys Cys  Ala Ser Leu Glu Lys  Thr Lys Gln Arg Leu  Gln Asn Glu 
    1415                 1420                 1425             


Val Glu  Asp Leu Met Ile Asp  Val Glu Arg Ser Asn  Ala Ala Cys 
    1430                 1435                 1440             


Ile Ala  Leu Asp Lys Lys Gln  Arg Asn Phe Asp Lys  Val Leu Ala 
    1445                 1450                 1455             


Glu Trp  Lys Gln Lys Tyr Glu  Glu Thr Gln Ala Glu  Leu Glu Ala 
    1460                 1465                 1470             


Ser Gln  Lys Glu Ser Arg Ser  Leu Ser Thr Glu Leu  Phe Lys Val 
    1475                 1480                 1485             


Lys Asn  Ala Tyr Glu Glu Ser  Leu Asp His Leu Glu  Thr Leu Lys 
    1490                 1495                 1500             


Arg Glu  Asn Lys Asn Leu Gln  Gln Glu Ile Ser Asp  Leu Thr Glu 
    1505                 1510                 1515             


Gln Ile  Ala Glu Gly Gly Lys  His Ile His Glu Leu  Glu Lys Val 
    1520                 1525                 1530             


Lys Lys  Gln Leu Asp His Glu  Lys Ser Glu Leu Gln  Thr Ser Leu 
    1535                 1540                 1545             


Glu Glu  Ala Glu Ala Ser Leu  Glu His Glu Glu Gly  Lys Ile Leu 
    1550                 1555                 1560             


Arg Ile  Gln Leu Glu Leu Asn  Gln Val Lys Ser Glu  Ile Asp Arg 
    1565                 1570                 1575             


Lys Ile  Ala Glu Lys Asp Glu  Glu Leu Asp Gln Leu  Lys Arg Asn 
    1580                 1585                 1590             


His Leu  Arg Val Val Glu Ser  Met Gln Ser Thr Leu  Asp Ala Glu 
    1595                 1600                 1605             


Ile Arg  Ser Arg Asn Asp Ala  Leu Arg Ile Lys Lys  Lys Met Glu 
    1610                 1615                 1620             


Gly Asp  Leu Asn Glu Met Glu  Ile Gln Leu Asn His  Ala Asn Arg 
    1625                 1630                 1635             


Gln Ala  Ala Glu Ala Leu Arg  Asn Leu Arg Asn Thr  Gln Gly Ile 
    1640                 1645                 1650             


Leu Lys  Asp Thr Gln Leu His  Leu Asp Asp Ala Ile  Arg Gly Gln 
    1655                 1660                 1665             


Asp Asp  Leu Lys Glu Gln Leu  Ala Met Val Glu Arg  Arg Ala Asn 
    1670                 1675                 1680             


Leu Met  Gln Ala Glu Val Glu  Glu Leu Arg Ala Ser  Leu Glu Arg 
    1685                 1690                 1695             


Thr Glu  Arg Gly Arg Lys Met  Ala Glu Gln Glu Leu  Leu Asp Ala 
    1700                 1705                 1710             


Ser Glu  Arg Val Gln Leu Leu  His Thr Gln Asn Thr  Ser Leu Ile 
    1715                 1720                 1725             


Asn Thr  Lys Lys Lys Leu Glu  Thr Asp Ile Ser Gln  Ile Gln Gly 
    1730                 1735                 1740             


Glu Met  Glu Asp Ile Val Gln  Glu Ala Arg Asn Ala  Glu Glu Lys 
    1745                 1750                 1755             


Ala Lys  Lys Ala Ile Thr Asp  Ala Ala Met Met Ala  Glu Glu Leu 
    1760                 1765                 1770             


Lys Lys  Glu Gln Asp Thr Ser  Ala His Leu Glu Arg  Met Lys Lys 
    1775                 1780                 1785             


Asn Met  Glu Gln Thr Val Lys  Asp Leu Gln Leu Arg  Leu Asp Glu 
    1790                 1795                 1800             


Ala Glu  Gln Leu Ala Leu Lys  Gly Gly Lys Lys Gln  Ile Gln Lys 
    1805                 1810                 1815             


Leu Glu  Ala Arg Val Arg Glu  Leu Glu Ser Glu Val  Glu Ser Glu 
    1820                 1825                 1830             


Gln Lys  His Asn Val Glu Ala  Val Lys Gly Leu Arg  Lys His Glu 
    1835                 1840                 1845             


Arg Arg  Val Lys Glu Leu Thr  Tyr Gln Thr Glu Glu  Asp Arg Lys 
    1850                 1855                 1860             


Asn Ile  Leu Arg Leu Gln Asp  Leu Val Asp Lys Leu  Gln Thr Lys 
    1865                 1870                 1875             


Val Lys  Ala Tyr Lys Arg Gln  Ala Glu Glu Ala Glu  Glu Gln Ser 
    1880                 1885                 1890             


Asn Val  Asn Leu Ala Lys Phe  Arg Lys Leu Gln His  Glu Leu Glu 
    1895                 1900                 1905             


Glu Ala  Lys Glu Arg Ala Asp  Ile Ala Glu Ser Gln  Val Asn Lys 
    1910                 1915                 1920             


Leu Arg  Val Lys Ser Arg Glu  Val His Thr Lys Val  Ile Ser Glu 
    1925                 1930                 1935             


Glu 
    


<210>  277
<211>  1939
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Thr Asp Ala Gln Met Ala Asp Phe Gly Ala Ala Ala Gln Tyr Leu 
1               5                   10                  15      


Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp 
            20                  25                  30          


Ile Arg Thr Glu Cys Phe Val Pro Asp Asp Lys Glu Glu Phe Val Lys 
        35                  40                  45              


Ala Lys Ile Leu Ser Arg Glu Gly Gly Lys Val Ile Ala Glu Thr Glu 
    50                  55                  60                  


Asn Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Leu Gln Gln Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu 
                85                  90                  95      


His Glu Pro Ala Val Leu Phe Asn Leu Lys Glu Arg Tyr Ala Ala Trp 
            100                 105                 110         


Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr 
        115                 120                 125             


Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Ala Ala Tyr Arg Gly 
    130                 135                 140                 


Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn 
145                 150                 155                 160 


Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile 
                165                 170                 175     


Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile 
            180                 185                 190         


Gln Tyr Phe Ala Ser Ile Ala Ala Ile Gly Asp Arg Gly Lys Lys Asp 
        195                 200                 205             


Asn Ala Asn Ala Asn Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala 
    210                 215                 220                 


Asn Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp 
225                 230                 235                 240 


Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr 
                245                 250                 255     


Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser 
            260                 265                 270         


Arg Val Ile Phe Gln Leu Lys Ala Glu Arg Asn Tyr His Ile Phe Tyr 
        275                 280                 285             


Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Val 
    290                 295                 300                 


Thr Asn Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu Val Ser 
305                 310                 315                 320 


Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Met Ala Thr Asp Ser Ala 
                325                 330                 335     


Phe Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Ala Gly Val Tyr Lys 
            340                 345                 350         


Leu Thr Gly Ala Ile Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys 
        355                 360                 365             


Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Asp Ala Asp Lys 
    370                 375                 380                 


Ser Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu 
385                 390                 395                 400 


Cys His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln 
                405                 410                 415     


Ser Val Gln Gln Val Tyr Tyr Ser Ile Gly Ala Leu Ala Lys Ala Val 
            420                 425                 430         


Tyr Glu Lys Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu 
        435                 440                 445             


Glu Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala 
    450                 455                 460                 


Gly Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn 
465                 470                 475                 480 


Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val 
                485                 490                 495     


Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile 
            500                 505                 510         


Asp Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro 
        515                 520                 525             


Met Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala 
    530                 535                 540                 


Thr Asp Met Thr Phe Lys Ala Lys Leu Tyr Asp Asn His Leu Gly Lys 
545                 550                 555                 560 


Ser Asn Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Gln Glu Ala 
                565                 570                 575     


His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn Ile Leu 
            580                 585                 590         


Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Ala 
        595                 600                 605             


Leu Tyr Gln Lys Ser Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Ser 
    610                 615                 620                 


Tyr Ala Thr Ala Asp Thr Gly Asp Ser Gly Lys Ser Lys Gly Gly Lys 
625                 630                 635                 640 


Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn 
                645                 650                 655     


Leu Asn Lys Leu Met Thr Asn Leu Arg Thr Thr His Pro His Phe Val 
            660                 665                 670         


Arg Cys Ile Ile Pro Asn Glu Arg Lys Ala Pro Gly Val Met Asp Asn 
        675                 680                 685             


Pro Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile 
    690                 695                 700                 


Arg Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe 
705                 710                 715                 720 


Arg Gln Arg Tyr Arg Ile Leu Asn Pro Val Ala Ile Pro Glu Gly Gln 
                725                 730                 735     


Phe Ile Asp Ser Arg Lys Gly Thr Glu Lys Leu Leu Ser Ser Leu Asp 
            740                 745                 750         


Ile Asp His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys 
        755                 760                 765             


Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser 
    770                 775                 780                 


Arg Ile Ile Thr Arg Met Gln Ala Gln Ala Arg Gly Gln Leu Met Arg 
785                 790                 795                 800 


Ile Glu Phe Lys Lys Ile Val Glu Arg Arg Asp Ala Leu Leu Val Ile 
                805                 810                 815     


Gln Trp Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met 
            820                 825                 830         


Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu 
        835                 840                 845             


Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gly Arg Ile Lys Glu Thr 
    850                 855                 860                 


Leu Glu Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val 
865                 870                 875                 880 


Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu 
                885                 890                 895     


Gln Asp Asn Leu Asn Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys 
            900                 905                 910         


Asn Lys Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu 
        915                 920                 925             


Glu Asp Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys 
    930                 935                 940                 


Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu 
945                 950                 955                 960 


Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys 
                965                 970                 975     


Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala 
            980                 985                 990         


Lys Leu Thr Lys Glu Lys Lys Ala  Leu Gln Glu Ala His  Gln Gln Ala 
        995                 1000                 1005             


Leu Asp  Asp Leu Gln Val Glu  Glu Asp Lys Val Asn  Ser Leu Ser 
    1010                 1015                 1020             


Lys Ser  Lys Val Lys Leu Glu  Gln Gln Val Asp Asp  Leu Glu Gly 
    1025                 1030                 1035             


Ser Leu  Glu Gln Glu Lys Lys  Val Arg Met Asp Leu  Glu Arg Ala 
    1040                 1045                 1050             


Lys Arg  Lys Leu Glu Gly Asp  Leu Lys Leu Thr Gln  Glu Ser Ile 
    1055                 1060                 1065             


Met Asp  Leu Glu Asn Asp Lys  Leu Gln Leu Glu Glu  Lys Leu Lys 
    1070                 1075                 1080             


Lys Lys  Glu Phe Asp Ile Asn  Gln Gln Asn Ser Lys  Ile Glu Asp 
    1085                 1090                 1095             


Glu Gln  Val Leu Ala Leu Gln  Leu Gln Lys Lys Leu  Lys Glu Asn 
    1100                 1105                 1110             


Gln Ala  Arg Ile Glu Glu Leu  Glu Glu Glu Leu Glu  Ala Glu Arg 
    1115                 1120                 1125             


Thr Ala  Arg Ala Lys Val Glu  Lys Leu Arg Ser Asp  Leu Ser Arg 
    1130                 1135                 1140             


Glu Leu  Glu Glu Ile Ser Glu  Arg Leu Glu Glu Ala  Gly Gly Ala 
    1145                 1150                 1155             


Thr Ser  Val Gln Ile Glu Met  Asn Lys Lys Arg Glu  Ala Glu Phe 
    1160                 1165                 1170             


Gln Lys  Met Arg Arg Asp Leu  Glu Glu Ala Thr Leu  Gln His Glu 
    1175                 1180                 1185             


Ala Thr  Ala Ala Ala Leu Arg  Lys Lys His Ala Asp  Ser Val Ala 
    1190                 1195                 1200             


Glu Leu  Gly Glu Gln Ile Asp  Asn Leu Gln Arg Val  Lys Gln Lys 
    1205                 1210                 1215             


Leu Glu  Lys Glu Lys Ser Glu  Phe Lys Leu Glu Leu  Asp Asp Val 
    1220                 1225                 1230             


Thr Ser  Asn Met Glu Gln Ile  Ile Lys Ala Lys Ala  Asn Leu Glu 
    1235                 1240                 1245             


Lys Val  Ser Arg Thr Leu Glu  Asp Gln Ala Asn Glu  Tyr Arg Val 
    1250                 1255                 1260             


Lys Leu  Glu Glu Ala Gln Arg  Ser Leu Asn Asp Phe  Thr Thr Gln 
    1265                 1270                 1275             


Arg Ala  Lys Leu Gln Thr Glu  Asn Gly Glu Leu Ala  Arg Gln Leu 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ala Leu Ile  Ser Gln Leu Thr Arg  Gly Lys Leu 
    1295                 1300                 1305             


Ser Tyr  Thr Gln Gln Met Glu  Asp Leu Lys Arg Gln  Leu Glu Glu 
    1310                 1315                 1320             


Glu Gly  Lys Ala Lys Asn Ala  Leu Ala His Ala Leu  Gln Ser Ala 
    1325                 1330                 1335             


Arg His  Asp Cys Asp Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Thr 
    1340                 1345                 1350             


Glu Ala  Lys Ala Glu Leu Gln  Arg Val Leu Ser Lys  Ala Asn Ser 
    1355                 1360                 1365             


Glu Val  Ala Gln Trp Arg Thr  Lys Tyr Glu Thr Asp  Ala Ile Gln 
    1370                 1375                 1380             


Arg Thr  Glu Glu Leu Glu Glu  Ala Lys Lys Lys Leu  Ala Gln Arg 
    1385                 1390                 1395             


Leu Gln  Asp Ala Glu Glu Ala  Val Glu Ala Val Asn  Ala Lys Cys 
    1400                 1405                 1410             


Ser Ser  Leu Glu Lys Thr Lys  His Arg Leu Gln Asn  Glu Ile Glu 
    1415                 1420                 1425             


Asp Leu  Met Val Asp Val Glu  Arg Ser Asn Ala Ala  Ala Ala Ala 
    1430                 1435                 1440             


Leu Asp  Lys Lys Gln Arg Asn  Phe Asp Lys Ile Leu  Ala Glu Trp 
    1445                 1450                 1455             


Lys Gln  Lys Tyr Glu Glu Ser  Gln Ser Glu Leu Glu  Ser Ser Gln 
    1460                 1465                 1470             


Lys Glu  Ala Arg Ser Leu Ser  Thr Glu Leu Phe Lys  Leu Lys Asn 
    1475                 1480                 1485             


Ala Tyr  Glu Glu Ser Leu Glu  His Leu Glu Thr Phe  Lys Arg Glu 
    1490                 1495                 1500             


Asn Lys  Asn Leu Gln Glu Glu  Ile Ser Asp Leu Thr  Glu Gln Leu 
    1505                 1510                 1515             


Gly Glu  Gly Gly Lys Asn Val  His Glu Leu Glu Lys  Val Arg Lys 
    1520                 1525                 1530             


Gln Leu  Glu Val Glu Lys Leu  Glu Leu Gln Ser Ala  Leu Glu Glu 
    1535                 1540                 1545             


Ala Glu  Ala Ser Leu Glu His  Glu Glu Gly Lys Ile  Leu Arg Ala 
    1550                 1555                 1560             


Gln Leu  Glu Phe Asn Gln Ile  Lys Ala Glu Ile Glu  Arg Lys Leu 
    1565                 1570                 1575             


Ala Glu  Lys Asp Glu Glu Met  Glu Gln Ala Lys Arg  Asn His Gln 
    1580                 1585                 1590             


Arg Val  Val Asp Ser Leu Gln  Thr Ser Leu Asp Ala  Glu Thr Arg 
    1595                 1600                 1605             


Ser Arg  Asn Glu Val Leu Arg  Val Lys Lys Lys Met  Glu Gly Asp 
    1610                 1615                 1620             


Leu Asn  Glu Met Glu Ile Gln  Leu Ser His Ala Asn  Arg Met Ala 
    1625                 1630                 1635             


Ala Glu  Ala Gln Lys Gln Val  Lys Ser Leu Gln Ser  Leu Leu Lys 
    1640                 1645                 1650             


Asp Thr  Gln Ile Gln Leu Asp  Asp Ala Val Arg Ala  Asn Asp Asp 
    1655                 1660                 1665             


Leu Lys  Glu Asn Ile Ala Ile  Val Glu Arg Arg Asn  Asn Leu Leu 
    1670                 1675                 1680             


Gln Ala  Glu Leu Glu Glu Leu  Arg Ala Val Val Glu  Gln Thr Glu 
    1685                 1690                 1695             


Arg Ser  Arg Lys Leu Ala Glu  Gln Glu Leu Ile Glu  Thr Ser Glu 
    1700                 1705                 1710             


Arg Val  Gln Leu Leu His Ser  Gln Asn Thr Ser Leu  Ile Asn Gln 
    1715                 1720                 1725             


Lys Lys  Lys Met Glu Ser Asp  Leu Thr Gln Leu Gln  Ser Glu Val 
    1730                 1735                 1740             


Glu Glu  Ala Val Gln Glu Cys  Arg Asn Ala Glu Glu  Lys Ala Lys 
    1745                 1750                 1755             


Lys Ala  Ile Thr Asp Ala Ala  Met Met Ala Glu Glu  Leu Lys Lys 
    1760                 1765                 1770             


Glu Gln  Asp Thr Ser Ala His  Leu Glu Arg Met Lys  Lys Asn Met 
    1775                 1780                 1785             


Glu Gln  Thr Ile Lys Asp Leu  Gln His Arg Leu Asp  Glu Ala Glu 
    1790                 1795                 1800             


Gln Ile  Ala Leu Lys Gly Gly  Lys Lys Gln Leu Gln  Lys Leu Glu 
    1805                 1810                 1815             


Ala Arg  Val Arg Glu Leu Glu  Gly Glu Leu Glu Ala  Glu Gln Lys 
    1820                 1825                 1830             


Arg Asn  Ala Glu Ser Val Lys  Gly Met Arg Lys Ser  Glu Arg Arg 
    1835                 1840                 1845             


Ile Lys  Glu Leu Thr Tyr Gln  Thr Glu Glu Asp Lys  Lys Asn Leu 
    1850                 1855                 1860             


Leu Arg  Leu Gln Asp Leu Val  Asp Lys Leu Gln Leu  Lys Val Lys 
    1865                 1870                 1875             


Ala Tyr  Lys Arg Gln Ala Glu  Glu Ala Glu Glu Gln  Ala Asn Thr 
    1880                 1885                 1890             


Asn Leu  Ser Lys Phe Arg Lys  Val Gln His Glu Leu  Asp Glu Ala 
    1895                 1900                 1905             


Glu Glu  Arg Ala Asp Ile Ala  Glu Ser Gln Val Asn  Lys Leu Arg 
    1910                 1915                 1920             


Ala Lys  Ser Arg Asp Ile Gly  Ala Lys Gln Lys Met  His Asp Glu 
    1925                 1930                 1935             


Glu 
    


<210>  278
<211>  1935
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Gly Asp Ser Glu Met Ala Val Phe Gly Ala Ala Ala Pro Tyr Leu 
1               5                   10                  15      


Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp 
            20                  25                  30          


Leu Lys Lys Asp Val Phe Val Pro Asp Asp Lys Gln Glu Phe Val Lys 
        35                  40                  45              


Ala Lys Ile Val Ser Arg Glu Gly Gly Lys Val Thr Ala Glu Thr Glu 
    50                  55                  60                  


Tyr Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Met Gln Gln Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu 
                85                  90                  95      


His Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Gly Ser Trp 
            100                 105                 110         


Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr 
        115                 120                 125             


Lys Trp Leu Pro Val Tyr Thr Pro Glu Val Val Ala Ala Tyr Arg Gly 
    130                 135                 140                 


Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn 
145                 150                 155                 160 


Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile 
                165                 170                 175     


Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile 
            180                 185                 190         


Gln Tyr Phe Ala Val Ile Ala Ala Ile Gly Asp Arg Ser Lys Lys Asp 
        195                 200                 205             


Gln Ser Pro Gly Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala Asn 
    210                 215                 220                 


Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp Asn 
225                 230                 235                 240 


Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr Gly 
                245                 250                 255     


Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg 
            260                 265                 270         


Val Ile Phe Gln Leu Lys Ala Glu Arg Asp Tyr His Ile Phe Tyr Gln 
        275                 280                 285             


Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Ile Thr 
    290                 295                 300                 


Asn Asn Pro Tyr Asp Tyr Ala Phe Ile Ser Gln Gly Glu Thr Thr Val 
305                 310                 315                 320 


Ala Ser Ile Asp Asp Ala Glu Glu Leu Met Ala Thr Asp Asn Ala Phe 
                325                 330                 335     


Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Asn Ser Met Tyr Lys Leu 
            340                 345                 350         


Thr Gly Ala Ile Met His Phe Gly Asn Met Lys Phe Lys Leu Lys Gln 
        355                 360                 365             


Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Glu Ala Asp Lys Ser 
    370                 375                 380                 


Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu Cys 
385                 390                 395                 400 


His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Asn 
                405                 410                 415     


Val Gln Gln Val Ile Tyr Ala Thr Gly Ala Leu Ala Lys Ala Val Tyr 
            420                 425                 430         


Glu Arg Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu Glu 
        435                 440                 445             


Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly 
    450                 455                 460                 


Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe 
465                 470                 475                 480 


Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val Leu 
                485                 490                 495     


Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile Asp 
            500                 505                 510         


Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met 
        515                 520                 525             


Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr 
    530                 535                 540                 


Asp Met Thr Phe Lys Ala Lys Leu Phe Asp Asn His Leu Gly Lys Ser 
545                 550                 555                 560 


Ala Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Pro Glu Ala His 
                565                 570                 575     


Phe Ser Leu Ile His Tyr Ala Gly Ile Val Asp Tyr Asn Ile Ile Gly 
            580                 585                 590         


Trp Leu Gln Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly Leu 
        595                 600                 605             


Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Thr Leu Phe Ala Asn Tyr 
    610                 615                 620                 


Ala Gly Ala Asp Ala Pro Ile Glu Lys Gly Lys Gly Lys Ala Lys Lys 
625                 630                 635                 640 


Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn Leu Asn 
                645                 650                 655     


Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe Val Arg Cys 
            660                 665                 670         


Ile Ile Pro Asn Glu Thr Lys Ser Pro Gly Val Met Asp Asn Pro Leu 
        675                 680                 685             


Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile 
    690                 695                 700                 


Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Arg Gln 
705                 710                 715                 720 


Arg Tyr Arg Ile Leu Asn Pro Ala Ala Ile Pro Glu Gly Gln Phe Ile 
                725                 730                 735     


Asp Ser Arg Lys Gly Ala Glu Lys Leu Leu Ser Ser Leu Asp Ile Asp 
            740                 745                 750         


His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala Gly 
        755                 760                 765             


Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser Arg Ile 
    770                 775                 780                 


Ile Thr Arg Ile Gln Ala Gln Ser Arg Gly Val Leu Ala Arg Met Glu 
785                 790                 795                 800 


Tyr Lys Lys Leu Leu Glu Arg Arg Asp Ser Leu Leu Val Ile Gln Trp 
                805                 810                 815     


Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met Lys Leu 
            820                 825                 830         


Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Arg Glu Lys Glu 
        835                 840                 845             


Met Ala Ser Met Lys Glu Glu Phe Thr Arg Leu Lys Glu Ala Leu Glu 
    850                 855                 860                 


Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val Ser Leu 
865                 870                 875                 880 


Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Gln Asp 
                885                 890                 895     


Asn Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Asn Lys 
            900                 905                 910         


Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu Glu Asp 
        915                 920                 925             


Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu Glu 
    930                 935                 940                 


Asp Glu Cys Ser Glu Leu Lys Arg Asp Ile Asp Asp Leu Glu Leu Thr 
945                 950                 955                 960 


Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val Lys 
                965                 970                 975     


Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala Lys Leu 
            980                 985                 990         


Thr Lys Glu Lys Lys Ala Leu Gln  Glu Ala His Gln Gln  Ala Leu Asp 
        995                 1000                 1005             


Asp Leu  Gln Ala Glu Glu Asp  Lys Val Asn Thr Leu  Thr Lys Ala 
    1010                 1015                 1020             


Lys Val  Lys Leu Glu Gln Gln  Val Asp Asp Leu Glu  Gly Ser Leu 
    1025                 1030                 1035             


Glu Gln  Glu Lys Lys Val Arg  Met Asp Leu Glu Arg  Ala Lys Arg 
    1040                 1045                 1050             


Lys Leu  Glu Gly Asp Leu Lys  Leu Thr Gln Glu Ser  Ile Met Asp 
    1055                 1060                 1065             


Leu Glu  Asn Asp Lys Gln Gln  Leu Asp Glu Arg Leu  Lys Lys Lys 
    1070                 1075                 1080             


Asp Phe  Glu Leu Asn Ala Leu  Asn Ala Arg Ile Glu  Asp Glu Gln 
    1085                 1090                 1095             


Ala Leu  Gly Ser Gln Leu Gln  Lys Lys Leu Lys Glu  Leu Gln Ala 
    1100                 1105                 1110             


Arg Ile  Glu Glu Leu Glu Glu  Glu Leu Glu Ala Glu  Arg Thr Ala 
    1115                 1120                 1125             


Arg Ala  Lys Val Glu Lys Leu  Arg Ser Asp Leu Ser  Arg Glu Leu 
    1130                 1135                 1140             


Glu Glu  Ile Ser Glu Arg Leu  Glu Glu Ala Gly Gly  Ala Thr Ser 
    1145                 1150                 1155             


Val Gln  Ile Glu Met Asn Lys  Lys Arg Glu Ala Glu  Phe Gln Lys 
    1160                 1165                 1170             


Met Arg  Arg Asp Leu Glu Glu  Ala Thr Leu Gln His  Glu Ala Thr 
    1175                 1180                 1185             


Ala Ala  Ala Leu Arg Lys Lys  His Ala Asp Ser Val  Ala Glu Leu 
    1190                 1195                 1200             


Gly Glu  Gln Ile Asp Asn Leu  Gln Arg Val Lys Gln  Lys Leu Glu 
    1205                 1210                 1215             


Lys Glu  Lys Ser Glu Phe Lys  Leu Glu Leu Asp Asp  Val Thr Ser 
    1220                 1225                 1230             


Asn Met  Glu Gln Ile Ile Lys  Ala Lys Ala Asn Leu  Glu Lys Met 
    1235                 1240                 1245             


Cys Arg  Thr Leu Glu Asp Gln  Met Asn Glu His Arg  Ser Lys Ala 
    1250                 1255                 1260             


Glu Glu  Thr Gln Arg Ser Val  Asn Asp Leu Thr Ser  Gln Arg Ala 
    1265                 1270                 1275             


Lys Leu  Gln Thr Glu Asn Gly  Glu Leu Ser Arg Gln  Leu Asp Glu 
    1280                 1285                 1290             


Lys Glu  Ala Leu Ile Ser Gln  Leu Thr Arg Gly Lys  Leu Thr Tyr 
    1295                 1300                 1305             


Thr Gln  Gln Leu Glu Asp Leu  Lys Arg Gln Leu Glu  Glu Glu Val 
    1310                 1315                 1320             


Lys Ala  Lys Asn Ala Leu Ala  His Ala Leu Gln Ser  Ala Arg His 
    1325                 1330                 1335             


Asp Cys  Asp Leu Leu Arg Glu  Gln Tyr Glu Glu Glu  Thr Glu Ala 
    1340                 1345                 1350             


Lys Ala  Glu Leu Gln Arg Val  Leu Ser Lys Ala Asn  Ser Glu Val 
    1355                 1360                 1365             


Ala Gln  Trp Arg Thr Lys Tyr  Glu Thr Asp Ala Ile  Gln Arg Thr 
    1370                 1375                 1380             


Glu Glu  Leu Glu Glu Ala Lys  Lys Lys Leu Ala Gln  Arg Leu Gln 
    1385                 1390                 1395             


Glu Ala  Glu Glu Ala Val Glu  Ala Val Asn Ala Lys  Cys Ser Ser 
    1400                 1405                 1410             


Leu Glu  Lys Thr Lys His Arg  Leu Gln Asn Glu Ile  Glu Asp Leu 
    1415                 1420                 1425             


Met Val  Asp Val Glu Arg Ser  Asn Ala Ala Ala Ala  Ala Leu Asp 
    1430                 1435                 1440             


Lys Lys  Gln Arg Asn Phe Asp  Lys Ile Leu Ala Glu  Trp Lys Gln 
    1445                 1450                 1455             


Lys Tyr  Glu Glu Ser Gln Ser  Glu Leu Glu Ser Ser  Gln Lys Glu 
    1460                 1465                 1470             


Ala Arg  Ser Leu Ser Thr Glu  Leu Phe Lys Leu Lys  Asn Ala Tyr 
    1475                 1480                 1485             


Glu Glu  Ser Leu Glu His Leu  Glu Thr Phe Lys Arg  Glu Asn Lys 
    1490                 1495                 1500             


Asn Leu  Gln Glu Glu Ile Ser  Asp Leu Thr Glu Gln  Leu Gly Ser 
    1505                 1510                 1515             


Ser Gly  Lys Thr Ile His Glu  Leu Glu Lys Val Arg  Lys Gln Leu 
    1520                 1525                 1530             


Glu Ala  Glu Lys Met Glu Leu  Gln Ser Ala Leu Glu  Glu Ala Glu 
    1535                 1540                 1545             


Ala Ser  Leu Glu His Glu Glu  Gly Lys Ile Leu Arg  Ala Gln Leu 
    1550                 1555                 1560             


Glu Phe  Asn Gln Ile Lys Ala  Glu Ile Glu Arg Lys  Leu Ala Glu 
    1565                 1570                 1575             


Lys Asp  Glu Glu Met Glu Gln  Ala Lys Arg Asn His  Leu Arg Val 
    1580                 1585                 1590             


Val Asp  Ser Leu Gln Thr Ser  Leu Asp Ala Glu Thr  Arg Ser Arg 
    1595                 1600                 1605             


Asn Glu  Ala Leu Arg Val Lys  Lys Lys Met Glu Gly  Asp Leu Asn 
    1610                 1615                 1620             


Glu Met  Glu Ile Gln Leu Ser  His Ala Asn Arg Met  Ala Ala Glu 
    1625                 1630                 1635             


Ala Gln  Lys Gln Val Lys Ser  Leu Gln Ser Leu Leu  Lys Asp Thr 
    1640                 1645                 1650             


Gln Ile  Gln Leu Asp Asp Ala  Val Arg Ala Asn Asp  Asp Leu Lys 
    1655                 1660                 1665             


Glu Asn  Ile Ala Ile Val Glu  Arg Arg Asn Asn Leu  Leu Gln Ala 
    1670                 1675                 1680             


Glu Leu  Glu Glu Leu Arg Ala  Val Val Glu Gln Thr  Glu Arg Ser 
    1685                 1690                 1695             


Arg Lys  Leu Ala Glu Gln Glu  Leu Ile Glu Thr Ser  Glu Arg Val 
    1700                 1705                 1710             


Gln Leu  Leu His Ser Gln Asn  Thr Ser Leu Ile Asn  Gln Lys Lys 
    1715                 1720                 1725             


Lys Met  Asp Ala Asp Leu Ser  Gln Leu Gln Thr Glu  Val Glu Glu 
    1730                 1735                 1740             


Ala Val  Gln Glu Cys Arg Asn  Ala Glu Glu Lys Ala  Lys Lys Ala 
    1745                 1750                 1755             


Ile Thr  Asp Ala Ala Met Met  Ala Glu Glu Leu Lys  Lys Glu Gln 
    1760                 1765                 1770             


Asp Thr  Ser Ala His Leu Glu  Arg Met Lys Lys Asn  Met Glu Gln 
    1775                 1780                 1785             


Thr Ile  Lys Asp Leu Gln His  Arg Leu Asp Glu Ala  Glu Gln Ile 
    1790                 1795                 1800             


Ala Leu  Lys Gly Gly Lys Lys  Gln Leu Gln Lys Leu  Glu Ala Arg 
    1805                 1810                 1815             


Val Arg  Glu Leu Glu Asn Glu  Leu Glu Ala Glu Gln  Lys Arg Asn 
    1820                 1825                 1830             


Ala Glu  Ser Val Lys Gly Met  Arg Lys Ser Glu Arg  Arg Ile Lys 
    1835                 1840                 1845             


Glu Leu  Thr Tyr Gln Thr Glu  Glu Asp Arg Lys Asn  Leu Leu Arg 
    1850                 1855                 1860             


Leu Gln  Asp Leu Val Asp Lys  Leu Gln Leu Lys Val  Lys Ala Tyr 
    1865                 1870                 1875             


Lys Arg  Gln Ala Glu Glu Ala  Glu Glu Gln Ala Asn  Thr Asn Leu 
    1880                 1885                 1890             


Ser Lys  Phe Arg Lys Val Gln  His Glu Leu Asp Glu  Ala Glu Glu 
    1895                 1900                 1905             


Arg Ala  Asp Ile Ala Glu Ser  Gln Val Asn Lys Leu  Arg Ala Lys 
    1910                 1915                 1920             


Ser Arg  Asp Ile Gly Thr Lys  Gly Leu Asn Glu Glu  
    1925                 1930                 1935 


<210>  279
<211>  1937
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Ser Ala Ser Ser Asp Ala Glu Met Ala Val Phe Gly Glu Ala Ala 
1               5                   10                  15      


Pro Tyr Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys 
            20                  25                  30          


Pro Phe Asp Ala Lys Thr Ser Val Phe Val Ala Glu Pro Lys Glu Ser 
        35                  40                  45              


Tyr Val Lys Ser Thr Ile Gln Ser Lys Glu Gly Gly Lys Val Thr Val 
    50                  55                  60                  


Lys Thr Glu Gly Gly Ala Thr Leu Thr Val Arg Glu Asp Gln Val Phe 
65                  70                  75                  80  


Pro Met Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met 
                85                  90                  95      


Thr His Leu His Glu Pro Gly Val Leu Tyr Asn Leu Lys Glu Arg Tyr 
            100                 105                 110         


Ala Ala Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val 
        115                 120                 125             


Asn Pro Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Ala Ala 
    130                 135                 140                 


Tyr Arg Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile 
145                 150                 155                 160 


Ser Asp Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser 
                165                 170                 175     


Ile Leu Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys 
            180                 185                 190         


Arg Val Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys 
        195                 200                 205             


Lys Asp Glu Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Thr Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Asp Ile Leu Gly Phe Thr Pro Glu Glu Lys Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Ser Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Leu Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Ala Asn Phe Gln Lys Pro Lys Val Val Lys Gly Lys Ala 
                565                 570                 575     


Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn 
            580                 585                 590         


Ile Thr Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Asp Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Ser Leu Phe 
    610                 615                 620                 


Ser Thr Tyr Ala Ser Ala Glu Ala Asp Ser Ser Ala Lys Lys Gly Ala 
625                 630                 635                 640 


Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu 
                645                 650                 655     


Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe 
            660                 665                 670         


Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu 
        675                 680                 685             


His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly 
    690                 695                 700                 


Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Gly Asp 
705                 710                 715                 720 


Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu Gly 
                725                 730                 735     


Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Ala Ser Ile 
            740                 745                 750         


Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe 
        755                 760                 765             


Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys Leu 
    770                 775                 780                 


Ala Gln Ile Ile Thr Arg Thr Gln Ala Val Cys Arg Gly Phe Leu Met 
785                 790                 795                 800 


Arg Val Glu Tyr Gln Lys Met Leu Gln Arg Arg Glu Ala Leu Phe Cys 
                805                 810                 815     


Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro Trp 
            820                 825                 830         


Met Lys Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr 
        835                 840                 845             


Glu Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys Thr Lys Asp 
    850                 855                 860                 


Glu Leu Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Met 
865                 870                 875                 880 


Val Thr Leu Leu Lys Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ser 
                885                 890                 895     


Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Glu Gln Leu Ile 
            900                 905                 910         


Lys Asn Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu Arg 
        915                 920                 925             


Ala Glu Glu Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg 
    930                 935                 940                 


Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu 
945                 950                 955                 960 


Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn 
                965                 970                 975     


Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr Ile 
            980                 985                 990         


Ala Lys Leu Ser Lys Glu Lys Lys  Ala Leu Gln Glu Thr  His Gln Gln 
        995                 1000                 1005             


Thr Leu  Asp Asp Leu Gln Ala  Glu Glu Asp Lys Val  Asn Ile Leu 
    1010                 1015                 1020             


Thr Lys  Ala Lys Thr Lys Leu  Glu Gln Gln Val Asp  Asp Leu Glu 
    1025                 1030                 1035             


Gly Ser  Leu Glu Gln Glu Lys  Lys Leu Arg Met Asp  Leu Glu Arg 
    1040                 1045                 1050             


Ala Lys  Arg Lys Leu Glu Gly  Asp Leu Lys Leu Ala  Gln Glu Ser 
    1055                 1060                 1065             


Thr Met  Asp Met Glu Asn Asp  Lys Gln Gln Leu Asp  Glu Lys Leu 
    1070                 1075                 1080             


Glu Lys  Lys Glu Phe Glu Ile  Ser Asn Leu Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Asp Glu  Gln Ala Val Glu Ile  Gln Leu Gln Lys Lys  Ile Lys Glu 
    1100                 1105                 1110             


Leu Gln  Ala Arg Ile Glu Glu  Leu Gly Glu Glu Ile  Glu Ala Glu 
    1115                 1120                 1125             


Arg Ala  Ser Arg Ala Lys Ala  Glu Lys Gln Arg Ser  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Leu Glu Glu Ile Ser  Glu Arg Leu Glu Glu  Ala Gly Gly 
    1145                 1150                 1155             


Ala Thr  Ser Ala Gln Val Glu  Leu Asn Lys Lys Arg  Glu Ala Glu 
    1160                 1165                 1170             


Phe Gln  Lys Leu Arg Arg Asp  Leu Glu Glu Ala Thr  Leu Gln His 
    1175                 1180                 1185             


Glu Ala  Met Val Ala Ala Leu  Arg Lys Lys His Ala  Asp Ser Met 
    1190                 1195                 1200             


Ala Glu  Leu Gly Glu Gln Ile  Asp Asn Leu Gln Arg  Val Lys Gln 
    1205                 1210                 1215             


Lys Leu  Glu Lys Glu Lys Ser  Glu Leu Lys Met Glu  Thr Asp Asp 
    1220                 1225                 1230             


Leu Ser  Ser Asn Ala Glu Ala  Ile Ser Lys Ala Lys  Gly Asn Leu 
    1235                 1240                 1245             


Glu Lys  Met Cys Arg Ser Leu  Glu Asp Gln Val Ser  Glu Leu Lys 
    1250                 1255                 1260             


Thr Lys  Glu Glu Glu Gln Gln  Arg Leu Ile Asn Asp  Leu Thr Ala 
    1265                 1270                 1275             


Gln Arg  Ala Arg Leu Gln Thr  Glu Ala Gly Glu Tyr  Ser Arg Gln 
    1280                 1285                 1290             


Leu Asp  Glu Lys Asp Ala Leu  Val Ser Gln Leu Ser  Arg Ser Lys 
    1295                 1300                 1305             


Gln Ala  Ser Thr Gln Gln Ile  Glu Glu Leu Lys His  Gln Leu Glu 
    1310                 1315                 1320             


Glu Glu  Thr Lys Ala Lys Asn  Ala Leu Ala His Ala  Leu Gln Ser 
    1325                 1330                 1335             


Ser Arg  His Asp Cys Asp Leu  Leu Arg Glu Gln Tyr  Glu Glu Glu 
    1340                 1345                 1350             


Gln Glu  Gly Lys Ala Glu Leu  Gln Arg Ala Leu Ser  Lys Ala Asn 
    1355                 1360                 1365             


Ser Glu  Val Ala Gln Trp Arg  Thr Lys Tyr Glu Thr  Asp Ala Ile 
    1370                 1375                 1380             


Gln Arg  Thr Glu Glu Leu Glu  Glu Ala Lys Lys Lys  Leu Ala Gln 
    1385                 1390                 1395             


Arg Leu  Gln Glu Ala Glu Glu  His Val Glu Ala Val  Asn Ala Lys 
    1400                 1405                 1410             


Cys Ala  Ser Leu Glu Lys Thr  Lys Gln Arg Leu Gln  Asn Glu Val 
    1415                 1420                 1425             


Glu Asp  Leu Met Leu Asp Val  Glu Arg Ser Asn Ala  Ala Cys Ala 
    1430                 1435                 1440             


Ala Leu  Asp Lys Lys Gln Arg  Asn Phe Asp Lys Val  Leu Ser Glu 
    1445                 1450                 1455             


Trp Lys  Gln Lys Tyr Glu Glu  Thr Gln Ala Glu Leu  Glu Ala Ser 
    1460                 1465                 1470             


Gln Lys  Glu Ser Arg Ser Leu  Ser Thr Glu Leu Phe  Lys Val Lys 
    1475                 1480                 1485             


Asn Val  Tyr Glu Glu Ser Leu  Asp Gln Leu Glu Thr  Leu Arg Arg 
    1490                 1495                 1500             


Glu Asn  Lys Asn Leu Gln Gln  Glu Ile Ser Asp Leu  Thr Glu Gln 
    1505                 1510                 1515             


Ile Ala  Glu Gly Gly Lys Gln  Ile His Glu Leu Glu  Lys Ile Lys 
    1520                 1525                 1530             


Lys Gln  Val Glu Gln Glu Lys  Cys Glu Ile Gln Ala  Ala Leu Glu 
    1535                 1540                 1545             


Glu Ala  Glu Ala Ser Leu Glu  His Glu Glu Gly Lys  Ile Leu Arg 
    1550                 1555                 1560             


Ile Gln  Leu Glu Leu Asn Gln  Val Lys Ser Glu Val  Asp Arg Lys 
    1565                 1570                 1575             


Ile Ala  Glu Lys Asp Glu Glu  Ile Asp Gln Leu Lys  Arg Asn His 
    1580                 1585                 1590             


Thr Arg  Val Val Glu Thr Met  Gln Ser Thr Leu Asp  Ala Glu Ile 
    1595                 1600                 1605             


Arg Ser  Arg Asn Asp Ala Leu  Arg Val Lys Lys Lys  Met Glu Gly 
    1610                 1615                 1620             


Asp Leu  Asn Glu Met Glu Ile  Gln Leu Asn His Ala  Asn Arg Leu 
    1625                 1630                 1635             


Ala Ala  Glu Ser Leu Arg Asn  Tyr Arg Asn Thr Gln  Gly Ile Leu 
    1640                 1645                 1650             


Lys Glu  Thr Gln Leu His Leu  Asp Asp Ala Leu Arg  Gly Gln Glu 
    1655                 1660                 1665             


Asp Leu  Lys Glu Gln Leu Ala  Ile Val Glu Arg Arg  Ala Asn Leu 
    1670                 1675                 1680             


Leu Gln  Ala Glu Ile Glu Glu  Leu Trp Ala Thr Leu  Glu Gln Thr 
    1685                 1690                 1695             


Glu Arg  Ser Arg Lys Ile Ala  Glu Gln Glu Leu Leu  Asp Ala Ser 
    1700                 1705                 1710             


Glu Arg  Val Gln Leu Leu His  Thr Gln Asn Thr Ser  Leu Ile Asn 
    1715                 1720                 1725             


Thr Lys  Lys Lys Leu Glu Asn  Asp Val Ser Gln Leu  Gln Ser Glu 
    1730                 1735                 1740             


Val Glu  Glu Val Ile Gln Glu  Ser Arg Asn Ala Glu  Glu Lys Ala 
    1745                 1750                 1755             


Lys Lys  Ala Ile Thr Asp Ala  Ala Met Met Ala Glu  Glu Leu Lys 
    1760                 1765                 1770             


Lys Glu  Gln Asp Thr Ser Ala  His Leu Glu Arg Met  Lys Lys Asn 
    1775                 1780                 1785             


Leu Glu  Gln Thr Val Lys Asp  Leu Gln His Arg Leu  Asp Glu Ala 
    1790                 1795                 1800             


Glu Gln  Leu Ala Leu Lys Gly  Gly Lys Lys Gln Ile  Gln Lys Leu 
    1805                 1810                 1815             


Glu Ala  Arg Val Arg Glu Leu  Glu Gly Glu Val Glu  Asn Glu Gln 
    1820                 1825                 1830             


Lys Arg  Asn Ala Glu Ala Val  Lys Gly Leu Arg Lys  His Glu Arg 
    1835                 1840                 1845             


Arg Val  Lys Glu Leu Thr Tyr  Gln Thr Glu Glu Asp  Arg Lys Asn 
    1850                 1855                 1860             


Val Leu  Arg Leu Gln Asp Leu  Val Asp Lys Leu Gln  Ala Lys Val 
    1865                 1870                 1875             


Lys Ser  Tyr Lys Arg Gln Ala  Glu Glu Ala Glu Glu  Gln Ser Asn 
    1880                 1885                 1890             


Ala Asn  Leu Ser Lys Phe Arg  Lys Leu Gln His Glu  Leu Glu Glu 
    1895                 1900                 1905             


Ala Glu  Glu Arg Ala Asp Ile  Ala Glu Ser Gln Val  Asn Lys Leu 
    1910                 1915                 1920             


Arg Val  Lys Ser Arg Glu Val  His Thr Lys Ile Ser  Ala Glu 
    1925                 1930                 1935         


<210>  280
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys 
1               5                   10                  15      


Pro Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser 
            20                  25                  30          


Ala Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu 
        35                  40                  45              


Pro Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg 
    50                  55                  60                  


Phe Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala 
65                  70                  75                  80  


Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr 
                85                  90                  95      


Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile 
            100                 105                 110         


Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly 
        115                 120                 125             


Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr 
    130                 135                 140                 


Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys 
145                 150                 155                 160 


Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp 
                165                 170                 175     


Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val 
            180                 185                 190         


Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu 
        195                 200                 205             


Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala 
    210                 215                 220                 


Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu 
225                 230                 235                 240 


Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp 
                245                 250                 255     


Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu 
            260                 265                 270         


Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp 
        275                 280                 285             


Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val 
    290                 295                 300                 


Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile 
305                 310                 315                 320 


Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro 
                325                 330                 335     


Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu 
            340                 345                 350         


Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala 
        355                 360                 365             


Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp 
    370                 375                 380                 


His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser 
385                 390                 395                 400 


Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His 
                405                 410                 415     


Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu 
            420                 425                 430         


Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu 
        435                 440                 445             


Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys 
    450                 455                 460                 


Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val 
465                 470                 475                 480 


Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp 
                485                 490                 495     


Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala 
            500                 505                 510         


Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile 
        515                 520                 525             


Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu 
    530                 535                 540                 


Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val 
545                 550                 555                 560 


Ile Thr 
        


<210>  281
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Ser Asp Phe Glu Glu Trp Ile Ser Gly Thr Tyr Arg Lys Met Glu 
1               5                   10                  15      


Glu Gly Pro Leu Pro Leu Leu Thr Phe Ala Thr Ala Pro Tyr His Asp 
            20                  25                  30          


Gln Lys Pro Gly Thr Ser Gly Leu Arg Lys Lys Thr Tyr Tyr Phe Glu 
        35                  40                  45              


Glu Lys Pro Cys Tyr Leu Glu Asn Phe Ile Gln Ser Ile Phe Phe Ser 
    50                  55                  60                  


Ile Asp Leu Lys Asp Arg Gln Gly Ser Ser Leu Val Val Gly Gly Asp 
65                  70                  75                  80  


Gly Arg Tyr Phe Asn Lys Ser Ala Ile Glu Thr Ile Val Gln Met Ala 
                85                  90                  95      


Ala Ala Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu 
            100                 105                 110         


Ser Thr Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly 
        115                 120                 125             


Gly Ile Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp 
    130                 135                 140                 


Phe Gly Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala 
145                 150                 155                 160 


Ile Thr Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala 
                165                 170                 175     


Val Cys Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln 
            180                 185                 190         


Phe Asp Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp 
        195                 200                 205             


Ser Val Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser 
    210                 215                 220                 


Ala Leu Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile 
225                 230                 235                 240 


Asp Ala Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys 
                245                 250                 255     


Glu Glu Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu 
            260                 265                 270         


Glu Asp Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala 
        275                 280                 285             


Asp Leu Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala 
    290                 295                 300                 


Phe Asp Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe 
305                 310                 315                 320 


Phe Val Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe 
                325                 330                 335     


Ser Ile Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser 
            340                 345                 350         


Met Pro Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile 
        355                 360                 365             


Ala Leu Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met 
    370                 375                 380                 


Asp Ala Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly 
385                 390                 395                 400 


Ser Asp His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp 
                405                 410                 415     


Leu Ser Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys 
            420                 425                 430         


Asp His Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr 
        435                 440                 445             


Glu Glu Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu 
    450                 455                 460                 


Ala Leu Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn 
465                 470                 475                 480 


Asp Lys Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp 
                485                 490                 495     


Pro Val Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe 
            500                 505                 510         


Thr Asp Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala 
        515                 520                 525             


Gly Ala Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala 
    530                 535                 540                 


Lys Ile Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile 
545                 550                 555                 560 


Ala Leu Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro 
                565                 570                 575     


Thr Val Ile Thr 
            580 


<210>  282
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly 
1               5                   10                  15      


Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn 
            20                  25                  30          


Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys 
        35                  40                  45              


Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu 
    50                  55                  60                  


Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro 
65                  70                  75                  80  


Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu 
                85                  90                  95      


Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala 
            100                 105                 110         


Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu 
        115                 120                 125             


Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro 
    130                 135                 140                 


Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val 
145                 150                 155                 160 


Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met 
                165                 170                 175     


Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys 
            180                 185                 190         


Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe 
        195                 200                 205             


Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile 
    210                 215                 220                 


Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met 
225                 230                 235                 240 


Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser 
                245                 250                 255     


Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys 
            260                 265                 270         


Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr 
        275                 280                 285             


Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala 
    290                 295                 300                 


Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser 
305                 310                 315                 320 


Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp 
                325                 330                 335     


Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr 
            340                 345                 350         


Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile 
        355                 360                 365             


Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn 
    370                 375                 380                 


Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu 
385                 390                 395                 400 


Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn 
                405                 410                 415     


Ile 
    


<210>  283
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Ala Ala Tyr Lys Leu Val Leu Ile Arg His Gly Glu Ser Ala Trp 
1               5                   10                  15      


Asn Leu Glu Asn Arg Phe Ser Gly Trp Tyr Asp Ala Asp Leu Ser Pro 
            20                  25                  30          


Ala Gly His Glu Glu Ala Lys Arg Gly Gly Gln Ala Leu Arg Asp Ala 
        35                  40                  45              


Gly Tyr Glu Phe Asp Ile Cys Phe Thr Ser Val Gln Lys Arg Ala Ile 
    50                  55                  60                  


Arg Thr Leu Trp Thr Val Leu Asp Ala Ile Asp Gln Met Trp Leu Pro 
65                  70                  75                  80  


Val Val Arg Thr Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr 
                85                  90                  95      


Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Ala Gln Val 
            100                 105                 110         


Lys Ile Trp Arg Arg Ser Tyr Asp Val Pro Pro Pro Pro Met Glu Pro 
        115                 120                 125             


Asp His Pro Phe Tyr Ser Asn Ile Ser Lys Asp Arg Arg Tyr Ala Asp 
    130                 135                 140                 


Leu Thr Glu Asp Gln Leu Pro Ser Cys Glu Ser Leu Lys Asp Thr Ile 
145                 150                 155                 160 


Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys 
                165                 170                 175     


Glu Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly 
            180                 185                 190         


Ile Val Lys His Leu Glu Gly Leu Ser Glu Glu Ala Ile Met Glu Leu 
        195                 200                 205             


Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asp Lys Asn Leu 
    210                 215                 220                 


Lys Pro Ile Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg 
225                 230                 235                 240 


Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys Lys 
                245                 250                 


<210>  284
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  285
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Val Arg 
385                 390                 395                 400 


Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  286
<211>  1001
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Glu Ala Ala His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe 
1               5                   10                  15      


Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala 
    210                 215                 220                 


Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys 
385                 390                 395                 400 


Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys 
    450                 455                 460                 


Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val 
        515                 520                 525             


Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val Lys Glu Lys 
    530                 535                 540                 


Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met 
                565                 570                 575     


Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr 
        595                 600                 605             


Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly 
625                 630                 635                 640 


Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg 
            660                 665                 670         


Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val 
        675                 680                 685             


Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala 
                725                 730                 735     


Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr 
        835                 840                 845             


Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His 
    850                 855                 860                 


Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn 
865                 870                 875                 880 


Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro 
                885                 890                 895     


Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg 
945                 950                 955                 960 


Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu 
            980                 985                 990         


Glu Asp Pro Glu Asp Glu Arg Arg  Lys 
        995                 1000     


<210>  287
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Glu Ala Ala His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe 
1               5                   10                  15      


Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala 
    210                 215                 220                 


Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys 
385                 390                 395                 400 


Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys 
    450                 455                 460                 


Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val 
        515                 520                 525             


Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val Lys Glu Lys 
    530                 535                 540                 


Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met 
                565                 570                 575     


Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr 
        595                 600                 605             


Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly 
625                 630                 635                 640 


Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg 
            660                 665                 670         


Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val 
        675                 680                 685             


Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala 
                725                 730                 735     


Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr 
        835                 840                 845             


Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His 
    850                 855                 860                 


Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn 
865                 870                 875                 880 


Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro 
                885                 890                 895     


Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg 
945                 950                 955                 960 


Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu 
            980                 985                 990         


Glu Gly 
        


<210>  288
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Val Gln Pro  Ala Thr Lys Ser Cys  Ser Phe Ser 
        995                 1000                 1005             


Ala Cys  Thr Asp Gly Ile Ser  Trp Pro Phe Val Leu  Leu Ile Met 
    1010                 1015                 1020             


Pro Leu  Val Ile Trp Val Tyr  Ser Thr Asp Thr Asn  Phe Ser Asp 
    1025                 1030                 1035             


Met Phe  Trp Ser 
    1040         


<210>  289
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  290
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Val Leu Ser Ser Glu Leu 
        995                 


<210>  291
<211>  1015
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Gly Glu Ser Val Ser Val 
145                 150                 155                 160 


Ile Lys His Thr Asp Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp 
                165                 170                 175     


Lys Lys Asn Met Leu Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala 
            180                 185                 190         


Met Gly Val Val Val Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile 
        195                 200                 205             


Arg Asp Glu Met Val Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln 
    210                 215                 220                 


Lys Leu Asp Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile 
225                 230                 235                 240 


Cys Ile Ala Val Trp Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val 
                245                 250                 255     


His Gly Gly Ser Trp Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala 
            260                 265                 270         


Val Ala Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile 
        275                 280                 285             


Thr Thr Cys Leu Ala Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala 
    290                 295                 300                 


Ile Val Arg Ser Leu Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val 
305                 310                 315                 320 


Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val 
                325                 330                 335     


Cys Arg Met Phe Ile Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu 
            340                 345                 350         


Asn Glu Phe Thr Ile Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val 
        355                 360                 365             


His Lys Asp Asp Lys Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val 
    370                 375                 380                 


Glu Leu Ala Thr Ile Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr 
385                 390                 395                 400 


Asn Glu Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr 
                405                 410                 415     


Ala Leu Thr Cys Leu Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu 
            420                 425                 430         


Lys Gly Leu Ser Lys Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile 
        435                 440                 445             


Lys Gln Leu Met Lys Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg 
    450                 455                 460                 


Lys Ser Met Ser Val Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser 
465                 470                 475                 480 


Met Ser Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg 
                485                 490                 495     


Cys Thr His Ile Arg Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly 
            500                 505                 510         


Val Lys Gln Lys Ile Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser 
        515                 520                 525             


Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg 
    530                 535                 540                 


Arg Glu Glu Met His Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu 
545                 550                 555                 560 


Thr Asn Leu Thr Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg 
                565                 570                 575     


Ile Glu Val Ala Ser Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg 
            580                 585                 590         


Val Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys 
        595                 600                 605             


Arg Arg Ile Gly Ile Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala 
    610                 615                 620                 


Phe Thr Gly Arg Glu Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp 
625                 630                 635                 640 


Ala Cys Leu Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys 
                645                 650                 655     


Ser Lys Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met 
            660                 665                 670         


Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile 
        675                 680                 685             


Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu 
    690                 695                 700                 


Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu 
705                 710                 715                 720 


Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu 
                725                 730                 735     


Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala 
            740                 745                 750         


Leu Gly Phe Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn 
        755                 760                 765             


Leu Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro 
    770                 775                 780                 


Asp Leu Asp Ile Met Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu 
785                 790                 795                 800 


Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val 
                805                 810                 815     


Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp 
            820                 825                 830         


Gly Gly Pro Arg Val Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys 
        835                 840                 845             


Lys Glu Asp Asn Pro Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu 
    850                 855                 860                 


Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu 
865                 870                 875                 880 


Met Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg 
                885                 890                 895     


Met Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser 
            900                 905                 910         


Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile 
        915                 920                 925             


Phe Gln Ile Thr Pro Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys 
    930                 935                 940                 


Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala 
945                 950                 955                 960 


Arg Asn Tyr Leu Glu Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys 
                965                 970                 975     


Ser Cys Ser Phe Ser Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val 
            980                 985                 990         


Leu Leu Ile Met Pro Leu Val Ile  Trp Val Tyr Ser Thr  Asp Thr Asn 
        995                 1000                 1005             


Phe Ser  Asp Met Phe Trp Ser  
    1010                 1015 


<210>  292
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Asp Ile Ile Lys 
        995         


<210>  293
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210>  294
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Pro His Pro Asn Cys Ile Phe Leu Tyr Cys Leu Tyr Leu 
            180                 185                 190         


His Pro Val Met Val Gly Thr Arg Pro Ile Pro Ser Pro Leu Thr Ile 
        195                 200                 205             


Met Val Gly Thr Lys Arg His Gln Gly Gly Phe Ser Leu Ala Glu Arg 
    210                 215                 220                 


Trp Lys Ala Trp Trp Asp Leu Leu Leu Gly Ser Leu Gly Pro Ser Glu 
225                 230                 235                 240 


Gly Arg Arg Glu Thr Ile Leu Ser Leu 
                245                 


<210>  295
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  296
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Cys Arg Leu Arg Ile Phe Leu Arg Thr Ala Ser Ser Glu His Leu 
1               5                   10                  15      


His Glu Arg Lys Leu Arg Glu Thr Ala Glu Ala Asp Val Ala Ser Leu 
            20                  25                  30          


Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp Arg Ala Gln Glu 
        35                  40                  45              


Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala Glu Lys Ala Ala 
    50                  55                  60                  


Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser Arg Ala Gln Lys 
65                  70                  75                  80  


Asp Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu Lys Glu Ala Lys 
                85                  90                  95      


His Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys 
            100                 105                 110         


Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu Glu Arg Ala Glu 
        115                 120                 125             


Leu Ser Glu Gly Gln Val Arg Gln Leu Glu Glu Gln Leu Arg Ile Met 
    130                 135                 140                 


Asp Ser Asp Leu Glu Ser Ile Asn Ala Ala Glu Asp Lys Tyr Ser Gln 
145                 150                 155                 160 


Lys Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu Ser Asp Lys Leu 
                165                 170                 175     


Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Thr Lys 
            180                 185                 190         


Leu Glu Lys Ser Ile Asp Asp Leu Glu Glu Lys Val Ala His Ala Lys 
        195                 200                 205             


Glu Glu Asn Leu Ser Met His Gln Met Leu Asp Gln Thr Leu Leu Glu 
    210                 215                 220                 


Leu Asn Asn Met 
225             


<210>  297
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  298
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  299
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Ala Gly Ser Ser Ser Leu Glu Ala Val Arg Arg Lys Ile Arg Ser 
1               5                   10                  15      


Leu Gln Glu Gln Ala Asp Ala Ala Glu Glu Arg Ala Gly Thr Leu Gln 
            20                  25                  30          


Arg Glu Leu Asp His Glu Arg Lys Leu Arg Glu Thr Ala Glu Ala Asp 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser 
                85                  90                  95      


Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu 
            180                 185                 190         


Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu Glu Asp Gln Leu 
    210                 215                 220                 


Tyr Gln Gln Leu Glu Gln Asn Arg Arg Leu Thr Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Asp 
                245 


<210>  300
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln Ala 
            20                  25                  30          


Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala Asp 
65                  70                  75                  80  


Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu 
                165                 170                 175     


Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  301
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             


<210>  302
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         


<210>  303
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Thr  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  304
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  305
<211>  4061
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210>  306
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Cys Asp Gln Gln Gln Ile Gln Cys Arg Leu Pro Leu Gln Gln Cys 
1               5                   10                  15      


Cys Val Lys Gly Pro Ser Phe Cys Ser Ser Gln Ser Pro Phe Ala Gln 
            20                  25                  30          


Ser Gln Val Val Val Gln Ala Pro Cys Glu Met Gln Ile Val Asp Cys 
        35                  40                  45              


Pro Ala Ser Cys Pro Val Gln Val Cys Gln Val Ser Asp Gln Ala Pro 
    50                  55                  60                  


Cys Gln Ser Gln Thr Thr Gln Val Lys Cys Gln Ser Lys Thr Lys Gln 
65                  70                  75                  80  


Val Lys Gly Gln Ala Gln Cys Gln Ser Lys Thr Thr Gln Val Lys Gly 
                85                  90                  95      


Gln Ala Ala Ser Gln Ser Gln Thr Ser Ser Val Gln Ser Gln Ala Pro 
            100                 105                 110         


Cys Gln Ser Glu Val Ser Tyr Val Gln Cys Glu Ala Ser Gln Pro Val 
        115                 120                 125             


Gln Thr Cys Phe Val Glu Cys Ala Pro Val Cys Tyr Thr Glu Thr Cys 
    130                 135                 140                 


Tyr Val Glu Cys Pro Val Gln Asn Tyr Val Pro Cys Pro Ala Pro Gln 
145                 150                 155                 160 


Pro Val Gln Met Tyr Arg Gly Arg Pro Ala Val Cys Gln Pro Gln Gly 
                165                 170                 175     


Arg Phe Ser Thr Gln Cys Gln Tyr Gln Gly Ser Tyr Ser Ser Cys Gly 
            180                 185                 190         


Pro Gln Phe Gln Ser Arg Ala Thr Cys Asn Asn Tyr Thr Pro Gln Phe 
        195                 200                 205             


Gln Leu Arg Pro Ser Tyr Ser Ser Cys Phe Pro Gln Tyr Arg Ser Arg 
    210                 215                 220                 


Thr Ser Phe Ser Pro Cys Val Pro Gln Cys Gln Thr Gln Gly Ser Tyr 
225                 230                 235                 240 


Gly Ser Phe Thr Glu Gln His Arg Ser Arg Ser Thr Ser Arg Cys Leu 
                245                 250                 255     


Pro Pro Pro Arg Arg Leu Gln Leu Phe Pro Arg Ser Cys Ser Pro Pro 
            260                 265                 270         


Arg Arg Phe Glu Pro Cys Ser Ser Ser Tyr Leu Pro Leu Arg Pro Ser 
        275                 280                 285             


Glu Gly Phe Pro Asn Tyr Cys Thr Pro Pro Arg Arg Ser Glu Pro Ile 
    290                 295                 300                 


Tyr Asn Ser Arg Cys Pro Arg Arg Pro Ile Ser Ser Cys Ser Gln Arg 
305                 310                 315                 320 


Arg Gly Pro Lys Cys Arg Ile Glu Ile Ser Ser Pro Cys Cys Pro Arg 
                325                 330                 335     


Gln Val Pro Pro Gln Arg Cys Pro Val Glu Ile Pro Pro Ile Arg Arg 
            340                 345                 350         


Arg Ser Gln Ser Cys Gly Pro Gln Pro Ser Trp Gly Ala Ser Cys Pro 
        355                 360                 365             


Glu Leu Arg Pro His Val Glu Pro Arg Pro Leu Pro Ser Phe Cys Pro 
    370                 375                 380                 


Pro Arg Arg Leu Asp Gln Cys Pro Glu Ser Pro Leu Gln Arg Cys Pro 
385                 390                 395                 400 


Pro Pro Ala Pro Arg Pro Arg Leu Arg Pro Glu Pro Cys Ile Ser Leu 
                405                 410                 415     


Glu Pro Arg Pro Arg Pro Leu Pro Arg Gln Leu Ser Glu Pro Cys Leu 
            420                 425                 430         


Tyr Pro Glu Pro Leu Pro Ala Leu Arg Pro Thr Pro Arg Pro Val Pro 
        435                 440                 445             


Leu Pro Arg Pro Gly Gln Cys Glu Ile Pro Glu Pro Arg Pro Cys Leu 
    450                 455                 460                 


Gln Pro Cys Glu His Pro Glu Pro Cys Pro Arg Pro Glu Pro Ile Pro 
465                 470                 475                 480 


Leu Pro Ala Pro Cys Pro Ser Pro Glu Pro Cys Arg Glu Thr Trp Arg 
                485                 490                 495     


Ser Pro Ser Pro Cys Trp Gly Pro Asn Pro Val Pro Tyr Pro Gly Asp 
            500                 505                 510         


Leu Gly Cys His Glu Ser Ser Pro His Arg Leu Asp Thr Glu Ala Pro 
        515                 520                 525             


Tyr Cys Gly Pro Ser Ser Tyr Asn Gln Gly Gln Glu Ser Gly Ala Gly 
    530                 535                 540                 


Cys Gly Pro Gly Asp Val Phe Pro Glu Arg Arg Gly Gln Asp Gly His 
545                 550                 555                 560 


Gly Asp Gln Gly Asn Ala Phe Ala Gly Val Lys Gly Glu Ala Lys Ser 
                565                 570                 575     


Ala Tyr Phe 
            


<210>  307
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Ala Thr Lys Cys Gly Asn Cys Gly Pro Gly Tyr Ser Thr Pro Leu 
1               5                   10                  15      


Glu Ala Met Lys Gly Pro Arg Glu Glu Ile Val Tyr Leu Pro Cys Ile 
            20                  25                  30          


Tyr Arg Asn Thr Gly Thr Glu Ala Pro Asp Tyr Leu Ala Thr Val Asp 
        35                  40                  45              


Val Asp Pro Lys Ser Pro Gln Tyr Cys Gln Val Ile His Arg Leu Pro 
    50                  55                  60                  


Met Pro Asn Leu Lys Asp Glu Leu His His Ser Gly Trp Asn Thr Cys 
65                  70                  75                  80  


Ser Ser Cys Phe Gly Asp Ser Thr Lys Ser Arg Thr Lys Leu Val Leu 
                85                  90                  95      


Pro Ser Leu Ile Ser Ser Arg Ile Tyr Val Val Asp Val Gly Ser Glu 
            100                 105                 110         


Pro Arg Ala Pro Lys Leu His Lys Val Ile Glu Pro Lys Asp Ile His 
        115                 120                 125             


Ala Lys Cys Glu Leu Ala Phe Leu His Thr Ser His Cys Leu Ala Ser 
    130                 135                 140                 


Gly Glu Val Met Ile Ser Ser Leu Gly Asp Val Lys Gly Asn Gly Lys 
145                 150                 155                 160 


Gly Gly Phe Val Leu Leu Asp Gly Glu Thr Phe Glu Val Lys Gly Thr 
                165                 170                 175     


Trp Glu Arg Pro Gly Gly Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr 
            180                 185                 190         


Gln Pro Arg His Asn Val Met Ile Ser Thr Glu Trp Ala Ala Pro Asn 
        195                 200                 205             


Val Leu Arg Asp Gly Phe Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr 
    210                 215                 220                 


Gly Ser His Leu Tyr Val Trp Asp Trp Gln Arg His Glu Ile Val Gln 
225                 230                 235                 240 


Thr Leu Ser Leu Lys Asp Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu 
                245                 250                 255     


His Asn Pro Asp Ala Ala Gln Gly Phe Val Gly Cys Ala Leu Ser Ser 
            260                 265                 270         


Thr Ile Gln Arg Phe Tyr Lys Asn Glu Gly Gly Thr Trp Ser Val Glu 
        275                 280                 285             


Lys Val Ile Gln Val Pro Pro Lys Lys Val Lys Gly Trp Leu Leu Pro 
    290                 295                 300                 


Glu Met Pro Gly Leu Ile Thr Asp Ile Leu Leu Ser Leu Asp Asp Arg 
305                 310                 315                 320 


Phe Leu Tyr Phe Ser Asn Trp Leu His Gly Asp Leu Arg Gln Tyr Asp 
                325                 330                 335     


Ile Ser Asp Pro Gln Arg Pro Arg Leu Thr Gly Gln Leu Phe Leu Gly 
            340                 345                 350         


Gly Ser Ile Val Lys Gly Gly Pro Val Gln Val Leu Glu Asp Glu Glu 
        355                 360                 365             


Leu Lys Ser Gln Pro Glu Pro Leu Val Val Lys Gly Lys Arg Val Ala 
    370                 375                 380                 


Gly Gly Pro Gln Met Ile Gln Leu Ser Leu Asp Gly Lys Arg Leu Tyr 
385                 390                 395                 400 


Ile Thr Thr Ser Leu Tyr Ser Ala Trp Asp Lys Gln Phe Tyr Pro Asp 
                405                 410                 415     


Leu Ile Arg Glu Gly Ser Val Met Leu Gln Val Asp Val Asp Thr Val 
            420                 425                 430         


Lys Gly Gly Leu Lys Leu Asn Pro Asn Phe Leu Val Asp Phe Gly Lys 
        435                 440                 445             


Glu Pro Leu Gly Pro Ala Leu Ala His Glu Leu Arg Tyr Pro Gly Gly 
    450                 455                 460                 


Asp Cys Ser Ser Asp Ile Trp Ile 
465                 470         


<210>  308
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Pro Asn Leu Lys Asp Glu Leu His His Ser Gly Trp Asn Thr Cys 
1               5                   10                  15      


Ser Ser Cys Phe Gly Asp Ser Thr Lys Ser Arg Thr Lys Leu Val Leu 
            20                  25                  30          


Pro Ser Leu Ile Ser Ser Arg Ile Tyr Val Val Asp Val Gly Ser Glu 
        35                  40                  45              


Pro Arg Ala Pro Lys Leu His Lys Val Ile Glu Pro Lys Asp Ile His 
    50                  55                  60                  


Ala Lys Cys Glu Leu Ala Phe Leu His Thr Ser His Cys Leu Ala Ser 
65                  70                  75                  80  


Gly Glu Val Met Ile Ser Ser Leu Gly Asp Val Lys Gly Asn Gly Lys 
                85                  90                  95      


Gly Gly Phe Val Leu Leu Asp Gly Glu Thr Phe Glu Val Lys Gly Thr 
            100                 105                 110         


Trp Glu Arg Pro Gly Gly Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr 
        115                 120                 125             


Gln Pro Arg His Asn Val Met Ile Ser Thr Glu Trp Ala Ala Pro Asn 
    130                 135                 140                 


Val Leu Arg Asp Gly Phe Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr 
145                 150                 155                 160 


Gly Ser His Leu Tyr Val Trp Asp Trp Gln Arg His Glu Ile Val Gln 
                165                 170                 175     


Thr Leu Ser Leu Lys Asp Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu 
            180                 185                 190         


His Asn Pro Asp Ala Ala Gln Gly Phe Val Gly Cys Ala Leu Ser Ser 
        195                 200                 205             


Thr Ile Gln Arg Phe Tyr Lys Asn Glu Gly Gly Thr Trp Ser Val Glu 
    210                 215                 220                 


Lys Val Ile Gln Val Pro Pro Lys Lys Val Lys Gly Trp Leu Leu Pro 
225                 230                 235                 240 


Glu Met Pro Gly Leu Ile Thr Asp Ile Leu Leu Ser Leu Asp Asp Arg 
                245                 250                 255     


Phe Leu Tyr Phe Ser Asn Trp Leu His Gly Asp Leu Arg Gln Tyr Asp 
            260                 265                 270         


Ile Ser Asp Pro Gln Arg Pro Arg Leu Thr Gly Gln Leu Phe Leu Gly 
        275                 280                 285             


Gly Ser Ile Val Lys Gly Gly Pro Val Gln Val Leu Glu Asp Glu Glu 
    290                 295                 300                 


Leu Lys Ser Gln Pro Glu Pro Leu Val Val Lys Gly Lys Arg Val Ala 
305                 310                 315                 320 


Gly Gly Pro Gln Met Ile Gln Leu Ser Leu Asp Gly Lys Arg Leu Tyr 
                325                 330                 335     


Ile Thr Thr Ser Leu Tyr Ser Ala Trp Asp Lys Gln Phe Tyr Pro Asp 
            340                 345                 350         


Leu Ile Arg Glu Gly Ser Val Met Leu Gln Val Asp Val Asp Thr Val 
        355                 360                 365             


Lys Gly Gly Leu Lys Leu Asn Pro Asn Phe Leu Val Asp Phe Gly Lys 
    370                 375                 380                 


Glu Pro Leu Gly Pro Ala Leu Ala His Glu Leu Arg Tyr Pro Gly Gly 
385                 390                 395                 400 


Asp Cys Ser Ser Asp Ile Trp Ile 
                405             


<210>  309
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Ala Thr Val Gln Gln Leu Glu Gly Arg Trp Arg Leu Val Asp Ser 
1               5                   10                  15      


Lys Gly Phe Asp Glu Tyr Met Lys Glu Leu Gly Val Gly Ile Ala Leu 
            20                  25                  30          


Arg Lys Met Gly Ala Met Ala Lys Pro Asp Cys Ile Ile Thr Cys Asp 
        35                  40                  45              


Gly Lys Asn Leu Thr Ile Lys Thr Glu Ser Thr Leu Lys Thr Thr Gln 
    50                  55                  60                  


Phe Ser Cys Thr Leu Gly Glu Lys Phe Glu Glu Thr Thr Ala Asp Gly 
65                  70                  75                  80  


Arg Lys Thr Gln Thr Val Cys Asn Phe Thr Asp Gly Ala Leu Val Gln 
                85                  90                  95      


His Gln Glu Trp Asp Gly Lys Glu Ser Thr Ile Thr Arg Lys Leu Lys 
            100                 105                 110         


Asp Gly Lys Leu Val Val Glu Cys Val Met Asn Asn Val Thr Cys Thr 
        115                 120                 125             


Arg Ile Tyr Glu Lys Val Glu 
    130                 135 


<210>  310
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ser Asn Val Pro His Lys Ser Ser Leu Pro Glu Gly Ile Arg Pro 
1               5                   10                  15      


Gly Thr Val Leu Arg Ile Arg Gly Leu Val Pro Pro Asn Ala Ser Arg 
            20                  25                  30          


Phe His Val Asn Leu Leu Cys Gly Glu Glu Gln Gly Ser Asp Ala Ala 
        35                  40                  45              


Leu His Phe Asn Pro Arg Leu Asp Thr Ser Glu Val Val Phe Asn Ser 
    50                  55                  60                  


Lys Glu Gln Gly Ser Trp Gly Arg Glu Glu Arg Gly Pro Gly Val Pro 
65                  70                  75                  80  


Phe Gln Arg Gly Gln Pro Phe Glu Val Leu Ile Ile Ala Ser Asp Asp 
                85                  90                  95      


Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His Phe Arg His 
            100                 105                 110         


Arg Leu Pro Leu Ala Arg Val Arg Leu Val Glu Val Gly Gly Asp Val 
        115                 120                 125             


Gln Leu Asp Ser Val Arg Ile Phe 
    130                 135     


<210>  311
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210>  312
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Ala Gly Glu Leu Thr Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala 
1               5                   10                  15      


Phe Ser Ala Val Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu 
            20                  25                  30          


Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gln 
        35                  40                  45              


Leu Arg Lys Leu Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile 
    50                  55                  60                  


Ser Phe Gln Glu Phe Leu Thr Ala Ala Lys Lys Ala Arg Ala Gly Leu 
65                  70                  75                  80  


Glu Asp Leu Gln Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly 
                85                  90                  95      


His Ile Thr Val Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln 
            100                 105                 110         


Pro Leu Pro Gln Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val 
        115                 120                 125             


Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala 
    130                 135                 140                 


Gln Glu 
145     


<210>  313
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Gly Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Arg Glu Tyr Arg Glu Lys Val Glu Thr Glu Leu Gln Gly Val Cys 
                85                  90                  95      


Asp Thr Val Leu Gly Leu Leu Asp Ser His Leu Ile Lys Glu Ala Gly 
            100                 105                 110         


Asp Ala Glu Ser Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
        115                 120                 125             


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
    130                 135                 140                 


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
            180                 185                 190         


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
        195                 200                 205             


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ala Asp Asn Ala Gly Glu Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Pro Gln Glu Pro Gln Ser 
                245             


<210>  314
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ser Lys 
1               5                   10                  15      


Ser Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Ile His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Ile Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ser Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Gly Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His His Lys Ala 
        115                 120                 125             


Gln Ser Lys 
    130     


<210>  315
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  316
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Ser Glu Thr Ala Pro Leu Ala Pro Thr Ile Pro Ala Pro Ala Glu 
1               5                   10                  15      


Lys Thr Pro Val Lys Lys Lys Ala Lys Lys Ala Gly Ala Thr Ala Gly 
            20                  25                  30          


Lys Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala 
        35                  40                  45              


Val Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys 
    50                  55                  60                  


Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg 
65                  70                  75                  80  


Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln 
                85                  90                  95      


Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala 
            100                 105                 110         


Ala Ser Gly Glu Gly Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys 
        115                 120                 125             


Pro Arg Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Val Ala Gly 
    130                 135                 140                 


Ala Ala Thr Pro Lys Lys Ser Ile Lys Lys Thr Pro Lys Lys Val Lys 
145                 150                 155                 160 


Lys Pro Ala Thr Ala Ala Gly Thr Lys Lys Val Ala Lys Ser Ala Lys 
                165                 170                 175     


Lys Val Lys Thr Pro Gln Pro Lys Lys Ala Ala Lys Ser Pro Ala Lys 
            180                 185                 190         


Ala Lys Ala Pro Lys Pro Lys Ala Ala Lys Pro Lys Ser Gly Lys Pro 
        195                 200                 205             


Lys Val Thr Lys Ala Lys Lys Ala Ala Pro Lys Lys Lys 
    210                 215                 220     


<210>  317
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala 
            100                 105                 110         


Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
        115                 120                 125             


Ala Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln 
    130                 135                 140                 


Gly Cys Gly Val 
145             


<210>  318
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln 
1               5                   10                  15      


Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys 
            20                  25                  30          


Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr 
        35                  40                  45              


Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His 
    50                  55                  60                  


Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr 
65                  70                  75                  80  


Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn 
                85                  90                  95      


Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro 
            100                 105                 110         


Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg 
        115                 120                 125             


His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile 
    130                 135                 140                 


Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr 
145                 150                 155                 160 


Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly 
                165                 170                 175     


Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly 
            180                 185                 190         


Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser 
        195                 200                 205             


Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu 
    210                 215                 220                 


Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile 
225                 230                 235                 240 


Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser 
                245                 250                 255     


Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr 
            260                 265                 270         


Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly 
        275                 280                 285             


Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln 
    290                 295                 300                 


Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr 
305                 310                 315                 320 


Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser 
                325                 330                 335     


Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly 
            340                 345                 350         


Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile 
        355                 360                 365             


Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser 
    370                 375                 380                 


Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro 
385                 390                 395                 400 


Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Lys Arg Leu Gly Met 
                405                 410                 415     


Arg Glu Leu Leu Ala Leu Val Pro Gln Arg Ala Thr Ser Ser Arg Val 
            420                 425                 430         


Asn Leu Ser Ser Ala Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser 
        435                 440                 445             


Gly Leu Ile Asp Ser Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala 
    450                 455                 460                 


Ser Arg Cys Asp Asp Lys Ser Val Glu Asn Cys Met Cys Val Leu His 
465                 470                 475                 480 


Asn Leu Ser Tyr Arg Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln 
                485                 490                 495     


Leu Glu Tyr Asn Ala Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly 
            500                 505                 510         


Cys Phe Ser Asn Lys Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys 
        515                 520                 525             


Pro Leu Pro Glu Glu Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr 
    530                 535                 540                 


His Ser Asp Ala Ile Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys 
545                 550                 555                 560 


Lys Asp Ala Thr Leu Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr 
                565                 570                 575     


Ala Ser Lys Gly Leu Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu 
            580                 585                 590         


Lys Glu Lys Gly Leu Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn 
        595                 600                 605             


Ser Asp Val Val Arg Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg 
    610                 615                 620                 


His Pro Leu Leu His Arg Val Met Gly Asn Gln Val Phe Pro Glu Val 
625                 630                 635                 640 


Thr Arg Leu Leu Thr Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp 
                645                 650                 655     


Ile Leu Ser Ser Ala Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln 
            660                 665                 670         


Pro Gln Leu Ala Lys Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile 
        675                 680                 685             


Ile Asn Leu Cys Arg Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala 
    690                 695                 700                 


Arg Leu Leu Leu Ser Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val 
705                 710                 715                 720 


Leu Arg Gln Gln Gly Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly 
                725                 730                 735     


Ala Asn Ser Leu Arg Asn Phe Thr Ser Arg Phe 
            740                 745         


<210>  319
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln 
1               5                   10                  15      


Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys 
            20                  25                  30          


Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr 
        35                  40                  45              


Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His 
    50                  55                  60                  


Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr 
65                  70                  75                  80  


Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn 
                85                  90                  95      


Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro 
            100                 105                 110         


Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg 
        115                 120                 125             


His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile 
    130                 135                 140                 


Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr 
145                 150                 155                 160 


Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly 
                165                 170                 175     


Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly 
            180                 185                 190         


Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser 
        195                 200                 205             


Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu 
    210                 215                 220                 


Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile 
225                 230                 235                 240 


Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser 
                245                 250                 255     


Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr 
            260                 265                 270         


Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly 
        275                 280                 285             


Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln 
    290                 295                 300                 


Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr 
305                 310                 315                 320 


Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser 
                325                 330                 335     


Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly 
            340                 345                 350         


Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile 
        355                 360                 365             


Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser 
    370                 375                 380                 


Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro 
385                 390                 395                 400 


Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Asn Leu Ser Ser Ala 
                405                 410                 415     


Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser Gly Leu Ile Asp Ser 
            420                 425                 430         


Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala Ser Arg Cys Asp Asp 
        435                 440                 445             


Lys Ser Val Glu Asn Cys Met Cys Val Leu His Asn Leu Ser Tyr Arg 
    450                 455                 460                 


Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln Leu Glu Tyr Asn Ala 
465                 470                 475                 480 


Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly Cys Phe Ser Asn Lys 
                485                 490                 495     


Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys Pro Leu Pro Glu Glu 
            500                 505                 510         


Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr His Ser Asp Ala Ile 
        515                 520                 525             


Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys Lys Asp Ala Thr Leu 
    530                 535                 540                 


Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr Ala Ser Lys Gly Leu 
545                 550                 555                 560 


Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu Lys Glu Lys Gly Leu 
                565                 570                 575     


Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn Ser Asp Val Val Arg 
            580                 585                 590         


Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg His Pro Leu Leu His 
        595                 600                 605             


Arg Val Met Gly Asn Gln Val Phe Pro Glu Val Thr Arg Leu Leu Thr 
    610                 615                 620                 


Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp Ile Leu Ser Ser Ala 
625                 630                 635                 640 


Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln Pro Gln Leu Ala Lys 
                645                 650                 655     


Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile Ile Asn Leu Cys Arg 
            660                 665                 670         


Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala Arg Leu Leu Leu Ser 
        675                 680                 685             


Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val Leu Arg Gln Gln Gly 
    690                 695                 700                 


Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly Ala Asn Ser Leu Arg 
705                 710                 715                 720 


Asn Phe Thr Ser Arg Phe 
                725     


<210>  320
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Asp Ala Gln Asp Cys Gln Ala Ala Ala Ser Pro Glu Pro Pro Gly 
1               5                   10                  15      


Pro Pro Ala Arg Ser Cys Val Ala Ala Trp Trp Asp Met Val Asp Arg 
            20                  25                  30          


Asn Leu Arg Tyr Phe Pro His Ser Cys Ser Met Leu Gly Arg Lys Ile 
        35                  40                  45              


Ala Ala Leu Tyr Asp Ser Phe Thr Ser Lys Ser Leu Lys Glu His Val 
    50                  55                  60                  


Phe Leu Pro Leu Ile Asp Met Leu Ile Tyr Phe Asn Phe Phe Lys Ala 
65                  70                  75                  80  


Pro Phe Leu Val Asp Leu Lys Lys Pro Glu Leu Lys Ile Pro His Thr 
                85                  90                  95      


Val Asn Phe Tyr Leu Arg Val Glu Pro Gly Val Met Leu Gly Ile Trp 
            100                 105                 110         


His Thr Val Pro Ser Cys Arg Gly Glu Asp Ala Lys Gly Lys Asp Cys 
        115                 120                 125             


Cys Trp Tyr Glu Ala Ala Leu Arg Asp Gly Asn Pro Ile Ile Val Tyr 
    130                 135                 140                 


Leu His Gly Ser Ala Glu His Arg Ala Ala Ser His Arg Leu Lys Leu 
145                 150                 155                 160 


Val Lys Val Leu Ser Asp Gly Gly Phe His Val Leu Ser Val Asp Tyr 
                165                 170                 175     


Arg Gly Phe Gly Asp Ser Thr Gly Lys Pro Thr Glu Glu Gly Leu Thr 
            180                 185                 190         


Thr Asp Ala Ile Cys Val Tyr Glu Trp Thr Lys Ala Arg Ser Gly Ile 
        195                 200                 205             


Thr Pro Val Cys Leu Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr 
    210                 215                 220                 


Asn Ala Ala Lys Val Leu Glu Glu Lys Gly Cys Pro Val Asp Ala Ile 
225                 230                 235                 240 


Val Leu Glu Ala Pro Phe Thr Asn Met Trp Val Ala Ser Ile Asn Tyr 
                245                 250                 255     


Pro Leu Leu Lys Ile Tyr Arg Asn Ile Pro Gly Phe Leu Arg Thr Leu 
            260                 265                 270         


Met Asp Ala Leu Arg Lys Asp Lys Ile Ile Phe Pro Asn Asp Glu Asn 
        275                 280                 285             


Val Lys Phe Leu Ser Ser Pro Leu Leu Ile Leu His Gly Glu Asp Asp 
    290                 295                 300                 


Arg Thr Val Pro Leu Glu Tyr Gly Lys Lys Leu Tyr Glu Ile Ala Arg 
305                 310                 315                 320 


Asn Ala Tyr Arg Asn Lys Glu Arg Val Lys Met Val Ile Phe Pro Pro 
                325                 330                 335     


Gly Phe Gln His Asn Leu Leu Cys Lys Ser Pro Thr Leu Leu Ile Thr 
            340                 345                 350         


Val Arg Asp Phe Leu Ser Lys Gln Trp Ser 
        355                 360         


<210>  321
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Asp Ala Gln Asp Cys Gln Ala Ala Ala Ser Pro Glu Pro Pro Gly 
1               5                   10                  15      


Pro Pro Ala Arg Ser Cys Val Ala Ala Trp Trp Asp Met Val Asp Arg 
            20                  25                  30          


Asn Leu Arg His Thr Val Pro Ser Cys Arg Gly Glu Asp Ala Lys Gly 
        35                  40                  45              


Lys Asp Cys Cys Trp Tyr Glu Ala Ala Leu Arg Asp Gly Asn Pro Ile 
    50                  55                  60                  


Ile Val Tyr Leu His Gly Ser Ala Glu His Arg Ala Ala Ser His Arg 
65                  70                  75                  80  


Leu Lys Leu Val Lys Val Leu Ser Asp Gly Gly Phe His Val Leu Ser 
                85                  90                  95      


Val Asp Tyr Arg Gly Phe Gly Asp Ser Thr Gly Lys Pro Thr Glu Glu 
            100                 105                 110         


Gly Leu Thr Thr Asp Ala Ile Cys Val Tyr Glu Trp Thr Lys Ala Arg 
        115                 120                 125             


Ser Gly Ile Thr Pro Val Cys Leu Trp Gly His Ser Leu Gly Thr Gly 
    130                 135                 140                 


Val Ala Thr Asn Ala Ala Lys Val Leu Glu Glu Lys Gly Cys Pro Val 
145                 150                 155                 160 


Asp Ala Ile Val Leu Glu Ala Pro Phe Thr Asn Met Trp Val Ala Ser 
                165                 170                 175     


Ile Asn Tyr Pro Leu Leu Lys Ile Tyr Arg Asn Ile Pro Gly Phe Leu 
            180                 185                 190         


Arg Thr Leu Met Asp Ala Leu Arg Lys Asp Lys Ile Ile Phe Pro Asn 
        195                 200                 205             


Asp Glu Asn Val Lys Phe Leu Ser Ser Pro Leu Leu Ile Leu His Gly 
    210                 215                 220                 


Glu Asp Asp Arg Thr Val Pro Leu Glu Tyr Gly Lys Lys Leu Tyr Glu 
225                 230                 235                 240 


Ile Ala Arg Asn Ala Tyr Arg Asn Lys Glu Arg Val Lys Met Val Ile 
                245                 250                 255     


Phe Pro Pro Gly Phe Gln His Asn Leu Leu Cys Lys Ser Pro Thr Leu 
            260                 265                 270         


Leu Ile Thr Val Arg Asp Phe Leu Ser Lys Gln Trp Ser 
        275                 280                 285 


<210>  322
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Leu Gly Ile Trp His Thr Val Pro Ser Cys Arg Gly Glu Asp Ala 
1               5                   10                  15      


Lys Gly Lys Asp Cys Cys Trp Tyr Glu Ala Ala Leu Arg Asp Gly Asn 
            20                  25                  30          


Pro Ile Ile Val Tyr Leu His Gly Ser Ala Glu His Arg Ala Ala Ser 
        35                  40                  45              


His Arg Leu Lys Leu Val Lys Val Leu Ser Asp Gly Gly Phe His Val 
    50                  55                  60                  


Leu Ser Val Asp Tyr Arg Gly Phe Gly Asp Ser Thr Gly Lys Pro Thr 
65                  70                  75                  80  


Glu Glu Gly Leu Thr Thr Asp Ala Ile Cys Val Tyr Glu Trp Thr Lys 
                85                  90                  95      


Ala Arg Ser Gly Ile Thr Pro Val Cys Leu Trp Gly His Ser Leu Gly 
            100                 105                 110         


Thr Gly Val Ala Thr Asn Ala Ala Lys Val Leu Glu Glu Lys Gly Cys 
        115                 120                 125             


Pro Val Asp Ala Ile Val Leu Glu Ala Pro Phe Thr Asn Met Trp Val 
    130                 135                 140                 


Ala Ser Ile Asn Tyr Pro Leu Leu Lys Ile Tyr Arg Asn Ile Pro Gly 
145                 150                 155                 160 


Phe Leu Arg Thr Leu Met Asp Ala Leu Arg Lys Asp Lys Ile Ile Phe 
                165                 170                 175     


Pro Asn Asp Glu Asn Val Lys Phe Leu Ser Ser Pro Leu Leu Ile Leu 
            180                 185                 190         


His Gly Glu Asp Asp Arg Thr Val Pro Leu Glu Tyr Gly Lys Lys Leu 
        195                 200                 205             


Tyr Glu Ile Ala Arg Asn Ala Tyr Arg Asn Lys Glu Arg Val Lys Met 
    210                 215                 220                 


Val Ile Phe Pro Pro Gly Phe Gln His Asn Leu Leu Cys Lys Ser Pro 
225                 230                 235                 240 


Thr Leu Leu Ile Thr Val Arg Asp Phe Leu Ser Lys Gln Trp Ser 
                245                 250                 255 


<210>  323
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Trp Val Ala Ser Ile Asn Tyr Pro Leu Leu Lys Ile Tyr Arg Asn 
1               5                   10                  15      


Ile Pro Gly Phe Leu Arg Thr Leu Met Asp Ala Leu Arg Lys Asp Lys 
            20                  25                  30          


Ile Ile Phe Pro Asn Asp Glu Asn Val Lys Phe Leu Ser Ser Pro Leu 
        35                  40                  45              


Leu Ile Leu His Gly Glu Asp Asp Arg Thr Val Pro Leu Glu Tyr Gly 
    50                  55                  60                  


Lys Lys Leu Tyr Glu Ile Ala Arg Asn Ala Tyr Arg Asn Lys Glu Arg 
65                  70                  75                  80  


Val Lys Met Val Ile Phe Pro Pro Gly Phe Gln His Asn Leu Leu Cys 
                85                  90                  95      


Lys Ser Pro Thr Leu Leu Ile Thr Val Arg Asp Phe Leu Ser Lys Gln 
            100                 105                 110         


Trp Ser 
        


<210>  324
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Asp Ala Gln Asp Cys Gln Ala Ala Ala Ser Pro Glu Pro Pro Gly 
1               5                   10                  15      


Pro Pro Ala Arg Ser Cys Val Ala Ala Trp Trp Asp Met Val Asp Arg 
            20                  25                  30          


Asn Leu Arg His Thr Val Pro Ser Cys Arg Gly Glu Asp Ala Lys Gly 
        35                  40                  45              


Lys Asp Cys Cys Trp Tyr Glu Ala Ala Leu Arg Asp Gly Asn Pro Ile 
    50                  55                  60                  


Ile Val Tyr Leu His Gly Ser Ala Glu His Arg Ala Ala Ser His Arg 
65                  70                  75                  80  


Leu Lys Leu Val Lys Val Leu Ser Asp Gly Gly Phe His Val Leu Ser 
                85                  90                  95      


Val Asp Tyr Arg Gly Phe Gly Asp Ser Thr Gly Lys Pro Thr Glu Glu 
            100                 105                 110         


Gly Leu Thr Thr Asp Ala Ile Cys Val Tyr Glu Trp Thr Lys Ala Arg 
        115                 120                 125             


Ser Gly Ile Thr Pro Val Cys Leu Trp Gly His Ser Leu Gly Thr Gly 
    130                 135                 140                 


Val Ala Thr Asn Ala Ala Lys Val Leu Glu Glu Lys Gly Cys Pro Val 
145                 150                 155                 160 


Asp Ala Ile Val Leu Glu Ala Pro Phe Thr Asn Met Trp Val Ala Ser 
                165                 170                 175     


Ile Asn Tyr Pro Leu Leu Lys Ser Leu Ala Leu Ser Ser Arg Leu Glu 
            180                 185                 190         


Cys Ser Gly Val Ile Ser Ala His Cys Lys Leu Arg Phe Pro Gly Ser 
        195                 200                 205             


Arg His Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Thr Thr Gly Ala 
    210                 215                 220                 


Arg His His Ala Trp Leu Ile Phe Leu Cys Phe 
225                 230                 235 


<210>  325
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp 
                165                 170                 175     


Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu 
            180                 185                 190         


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205             


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220                 


Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240 


Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser 
                245                 250                 255     


Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala 
            260                 265                 270         


Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val 
        275                 280                 285             


Gly Ala Thr Thr Asp Trp Ser 
    290                 295 


<210>  326
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys 
        


<210>  327
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Val Thr Gln Asn Phe 
        35                  40                  45              


Leu Ile Leu Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala 
    50                  55                  60                  


Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser 
65                  70                  75                  80  


Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys 
                85                  90                  95      


Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala 
            100                 105                 110         


Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val 
        115                 120                 125             


Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr 
    130                 135                 140                 


Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys 
                165                 170                 175     


Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro 
            180                 185                 190         


Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met 
        195                 200                 205             


Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu 
    210                 215                 220                 


Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp 
225                 230                 235                 240 


Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val 
                245                 250                 255     


Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile 
            260                 265                 270         


Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro 
        275                 280                 285             


Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala 
    290                 295                 300                 


Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His 
305                 310                 315                 320 


Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys 
                325                 330 


<210>  328
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Thr Arg Thr Val Asn 
        195                 200                 205             


Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly 
    210                 215                 220                 


Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys 
225                 230                 235     


<210>  329
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  330
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  331
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys 
1               5                   10                  15      


Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 
            20                  25                  30          


Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 
        35                  40                  45              


Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 
    50                  55                  60                  


Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu 
65                  70                  75                  80  


Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ala 
                85                  90                  95      


Leu Leu Asp Asn Glu Asp Asp Glu Met Gln His Asn Glu Gly Gln Glu 
            100                 105                 110         


Arg Ser Ser Asn Asn Phe Asn Tyr Gly Ala Tyr His Ser Leu Glu Ala 
        115                 120                 125             


Ile Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala 
    130                 135                 140                 


Arg Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val 
145                 150                 155                 160 


Leu Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu 
                165                 170                 175     


Asn Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile 
            180                 185                 190         


Trp Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile 
        195                 200                 205             


Thr Ser Ile Leu Glu Lys Met Asp Ile Phe Leu Leu Pro Val Ala Asn 
    210                 215                 220                 


Pro Asp Gly Tyr Val Tyr Thr Gln Thr Gln Asn Arg Leu Trp Arg Lys 
225                 230                 235                 240 


Thr Arg Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn 
                245                 250                 255     


Arg Asn Trp Asn Ala Ser Phe Ala Gly Lys Gly Ala Ser Asp Asn Pro 
            260                 265                 270         


Cys Ser Glu Val Tyr His Gly Pro His Ala Asn Ser Glu Val Glu Val 
        275                 280                 285             


Lys Ser Val Val Asp Phe Ile Gln Lys His Gly Asn Phe Lys Gly Phe 
    290                 295                 300                 


Ile Asp Leu His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr 
305                 310                 315                 320 


Ser Val Lys Lys Ala Pro Asp Ala Glu Glu Leu Asp Lys Val Ala Arg 
                325                 330                 335     


Leu Ala Ala Lys Ala Leu Ala Ser Val Ser Gly Thr Glu Tyr Gln Val 
            340                 345                 350         


Gly Pro Thr Cys Thr Thr Val Tyr Pro Ala Ser Gly Ser Ser Ile Asp 
        355                 360                 365             


Trp Ala Tyr Asp Asn Gly Ile Lys Phe Ala Phe Thr Phe Glu Leu Arg 
    370                 375                 380                 


Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Ala Asn Gln Ile Ile Pro 
385                 390                 395                 400 


Thr Ala Glu Glu Thr Trp Leu Gly Leu Lys Thr Ile Met Glu His Val 
                405                 410                 415     


Arg Asp Asn Leu Tyr 
            420     


<210>  332
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  333
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  334
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  335
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Gly Val Gly Arg Arg Lys Ser 
            20                  25                  


<210>  336
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Ala 
            180                 185                 190         


Leu Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln 
        195                 200                 205             


Glu Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys 
    210                 215                 220                 


Asn His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr 
225                 230                 235                 240 


Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp 
                245                 250                 255     


Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe 
            260                 265                 270         


Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys 
        275                 280                 285             


Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu 
    290                 295                 300                 


Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly 
305                 310                 315                 320 


Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu 
                325                 330                 335     


Ile His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser 
            340                 345                 350         


Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln 
        355                 360                 365             


Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr 
    370                 375                 380                 


Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala 
385                 390                 395                 400 


His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp 
                405                 410                 415     


Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg 
            420                 425                 430         


Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile 
        435                 440                 445             


Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu 
    450                 455                 460                 


Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln 
465                 470                 475                 480 


Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro 
                485                 490                 495     


Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly 
            500                 505                 510         


Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly 
        515                 520                 525             


Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro 
    530                 535                 540                 


Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val 
545                 550                 555                 560 


Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp 
                565                 570                 575     


Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser 
            580                 585                 590         


Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser 
        595                 600                 605             


Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala 
    610                 615                 620                 


Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn 
625                 630                 635                 640 


Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly 
                645                 650                 655     


Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala 
            660                 665                 670         


Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu 
        675                 680                 685             


Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn 
    690                 695                 700                 


Val Asp Met Lys Ile Gly Val 
705                 710     


<210>  337
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     


His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         


Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  338
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Ala Gly Trp Glu Pro Asn Glu 
            260                 265                 270         


Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly 
        275                 280                 285             


Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro 
    290                 295                 300                 


Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn 
305                 310                 315                 320 


Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met 
                325                 330                 335     


Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn 
            340                 345                 350         


Pro Glu Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu 
        355                 360                 365             


Glu Thr Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr 
    370                 375                 380                 


Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp 
385                 390                 395                 400 


His Glu Gly Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr 
                405                 410                 415     


Gly Thr Ala Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg 
            420                 425                 430         


Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro 
        435                 440                 445             


Ile Ser His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp 
    450                 455                 460                 


Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn 
465                 470                 475                 480 


Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr 
                485                 490                 495     


Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu 
            500                 505                 510         


Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn 
        515                 520                 525             


Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly 
    530                 535                 540                 


Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys 
545                 550                 555                 560 


Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe 
                565                 570                 575     


Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg 
            580                 585                 590         


Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His 
        595                 600                 605             


Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu 
    610                 615                 620                 


Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro 
625                 630                 635                 640 


Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu 
                645                 650                 655     


Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys 
            660                 665                 670         


Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro 
        675                 680                 685             


Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu 
    690                 695                 700                 


Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp 
705                 710                 715                 720 


Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                725                 730                 


<210>  339
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Thr Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  340
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Arg Asn Arg Asn Asp Val Thr 
            500                 505                 510         


Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu 
        515                 520                 525             


Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe 
    530                 535                 540                 


Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val 
545                 550                 555                 560 


Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp 
                565                 570                 575     


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
            580                 585                 590         


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
        595                 600                 605             


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
    610                 615                 620                 


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
625                 630                 635                 640 


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
                645                 650                 655     


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
            660                 665                 670         


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
        675                 680                 685             


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
    690                 695                 700                 


Gln Asn Val Asp Met Lys Ile Gly Val 
705                 710             


<210>  341
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Arg Asp Gln Asp Thr Phe His Pro Ser 
    530                 535                 540                 


Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His 
545                 550                 555                 560 


Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr 
                565                 570                 575     


Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu 
            580                 585                 590         


Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys 
        595                 600                 605             


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu 
    610                 615                 620                 


Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu 
625                 630                 635                 640 


Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe 
                645                 650                 655     


Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile 
            660                 665                 670         


Gly Val 
        


<210>  342
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Ser 
        675 


<210>  343
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
305                 310                 315                 320 


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
                325                 330                 335     


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
        355                 360                 365             


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
465                 470                 475                 480 


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210>  344
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Arg 
    210                 215                 220                 


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
225                 230                 235                 240 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
                245                 250                 255     


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
            260                 265                 270         


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
        275                 280                 285             


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
    290                 295                 300                 


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
305                 310                 315                 320 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
                325                 330                 335     


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
            340                 345                 350         


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
        355                 360                 365             


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
    370                 375                 380                 


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
385                 390                 395                 400 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
                405                 410                 415     


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
            420                 425                 


<210>  345
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly 
        355                 360 


<210>  346
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Arg Asp 
        275                 280                 285             


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
    290                 295                 300                 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
305                 310                 315                 320 


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
                325                 330                 335     


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
            340                 345                 350         


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
        355                 360                 365             


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
    370                 375                 380                 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
385                 390                 395                 400 


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
                405                 410                 415     


Gln Asn Val Asp Met Lys Ile Gly Val 
            420                 425 


<210>  347
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Arg Arg Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr 
            260                 265                 270         


His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly 
        275                 280                 285             


Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp 
    290                 295                 300                 


Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val 
305                 310                 315                 320 


Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu 
                325                 330                 335     


Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly 
            340                 345                 350         


Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn 
        355                 360                 365             


Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr 
    370                 375                 380                 


Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
385                 390                 395     


<210>  348
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Ser 
    290                 


<210>  349
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Ala 
            180                 185                 190         


Leu Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln 
        195                 200                 205             


Glu Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys 
    210                 215                 220                 


Asn His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr 
225                 230                 235                 240 


Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp 
                245                 250                 255     


Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe 
            260                 265                 270         


Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys 
        275                 280                 285             


Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu 
    290                 295                 300                 


Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly 
305                 310                 315                 320 


Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu 
                325                 330                 335     


Ile His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser 
            340                 345                 350         


Thr Thr Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr 
        355                 360                 365             


Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser 
    370                 375                 380                 


His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp 
385                 390                 395                 400 


Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly 
                405                 410                 415     


Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln 
            420                 425                 430         


Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu 
        435                 440                 445             


Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn 
    450                 455                 460                 


Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr 
465                 470                 475                 480 


Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser 
                485                 490                 495     


Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val 
            500                 505                 510         


Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu 
        515                 520                 525             


Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr 
    530                 535                 540                 


His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly 
545                 550                 555                 560 


Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp 
                565                 570                 575     


Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val 
            580                 585                 590         


Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu 
        595                 600                 605             


Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly 
    610                 615                 620                 


Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn 
625                 630                 635                 640 


Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr 
                645                 650                 655     


Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
            660                 665             


<210>  350
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Ala Gly Trp Glu Pro Asn Glu 
            260                 265                 270         


Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly 
        275                 280                 285             


Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro 
    290                 295                 300                 


Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn 
305                 310                 315                 320 


Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met 
                325                 330                 335     


Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn 
            340                 345                 350         


Pro Glu Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu 
        355                 360                 365             


Glu Thr Pro His Ser Thr Ser Thr Thr Ala Ser Ala His Thr Ser His 
    370                 375                 380                 


Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp Thr 
385                 390                 395                 400 


Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln Ala 
                405                 410                 415     


Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro 
            420                 425                 430         


Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly 
        435                 440                 445             


Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr 
    450                 455                 460                 


Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr 
465                 470                 475                 480 


Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro 
                485                 490                 495     


Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His 
            500                 505                 510         


Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala 
        515                 520                 525             


Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn 
    530                 535                 540                 


Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro 
545                 550                 555                 560 


Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser 
                565                 570                 575     


His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg 
            580                 585                 590         


Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala 
        595                 600                 605             


Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg 
    610                 615                 620                 


Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val 
625                 630                 635                 640 


Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln 
                645                 650                 655     


Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln 
            660                 665                 670         


Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys 
        675                 680                 685             


Ile Gly Val 
    690     


<210>  351
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      


Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         


Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 


Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     


Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met 
            260                 265                 270         


Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys 
    290                 295                 300                 


His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             


Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     


<210>  352
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro 
            340                 345                 350         


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
        355                 360                 365             


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro 
    370                 375                 380                 


Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys 
385                 390                 395                 400 


Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp 
                405                 410                 415     


Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn 
            420                 425                 430         


Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val 
        435                 440                 445             


Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg 
    450                 455                 460                 


Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
465                 470                 475     


<210>  353
<211>  466
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (295)..(295)
<223>  Xaa can be any naturally occurring amino acid

<400>  353

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro 
            260                 265                 270         


Gly Asn Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg 
        275                 280                 285             


Gly Pro Gly Ser Phe Pro Xaa Asn Met Arg Glu Ile Ser Lys Glu Gly 
    290                 295                 300                 


Asn Arg Leu Leu Gly Gly Ser Gly Asp Asn Tyr Arg Gly Gln Gly Ser 
305                 310                 315                 320 


Ser Trp Gly Ser Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val 
                325                 330                 335     


Asn Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys 
            340                 345                 350         


Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys 
        355                 360                 365             


Asn Gln Val Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg 
    370                 375                 380                 


Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala 
385                 390                 395                 400 


Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg 
                405                 410                 415     


Asp Asp Gln Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr 
            420                 425                 430         


Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro 
        435                 440                 445             


Ser Ser Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys 
    450                 455                 460                 


Phe Trp 
465     


<210>  354
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro 
            340                 345                 350         


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
        355                 360                 365             


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg 
    370                 375                 380                 


Ile Pro 
385     


<210>  355
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro 
            260                 265                 270         


Gly Asn Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Gln Gly 
        275                 280                 285             


Ser Ser Trp Gly Ser Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr 
    290                 295                 300                 


Val Asn Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp 
305                 310                 315                 320 


Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn 
                325                 330                 335     


Lys Asn Gln Val Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser 
            340                 345                 350         


Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys 
        355                 360                 365             


Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly 
    370                 375                 380                 


Arg Asp Asp Gln Pro Gly Ala Gly Trp Gln Glu Val Ala Ala Val Thr 
385                 390                 395                 400 


Ser Lys Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly 
                405                 410                 415     


Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser 
            420                 425                 430         


Ser Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe 
        435                 440                 445             


Trp 
    


<210>  356
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln Gly 
            340                 345                 350         


Val Ser Ser Asn Met Arg Asn Ser Glu Thr Ser Pro Gly Met Phe Asn 
        355                 360                 365             


Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn 
    370                 375                 380                 


Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg Ile Pro 
385                 390                 395             


<210>  357
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln Gly 
            340                 345                 350         


Val Ser Ser Asn Met Arg Glu Ile Ser Lys Glu Gly Asn Arg Leu Leu 
        355                 360                 365             


Gly Gly Ser Gly Asp Asn Tyr Arg Gly Gln Gly Ser Ser Trp Gly Ser 
    370                 375                 380                 


Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val Asn Ser Glu Thr 
385                 390                 395                 400 


Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser 
                405                 410                 415     


Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser 
            420                 425                 430         


Ser Arg Ile Pro 
        435     


<210>  358
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Asn Ser Glu Thr Ser Pro Gly 
                325                 330                 335     


Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
            340                 345                 350         


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg Ile 
        355                 360                 365             


Pro 
    


<210>  359
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser 
    50                  55                  60                  


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro 
                85                  90                  95      


Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe 
            100                 105                 110         


Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala 
        115                 120                 125             


Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr 
    130                 135                 140                 


Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser 
145                 150                 155                 160 


Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser 
                165                 170                 175     


Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
            180                 185                 


<210>  360
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Ser Pro Pro Asp Gln Gly Val Val Glu Ser Arg Leu Trp Arg Gln 
1               5                   10                  15      


Met Leu His Lys Gly Gln Gly Ser Ser Trp Gly Ser Gly Gly Gly Asp 
            20                  25                  30          


Ala Val Gly Gly Val Asn Thr Val Asn Ser Glu Thr Ser Pro Gly Met 
        35                  40                  45              


Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe 
    50                  55                  60                  


Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser Thr 
65                  70                  75                  80  


Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln Asn 
                85                  90                  95      


Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser 
            100                 105                 110         


Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn 
        115                 120                 125             


Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr 
    130                 135                 140                 


Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln 
145                 150                 155                 160 


Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                165                 170 


<210>  361
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Arg Gly Gln Gly Ser Ser Trp Gly Ser Gly Gly Gly Asp Ala Val 
1               5                   10                  15      


Gly Gly Val Asn Thr Val Asn Ser Glu Thr Ser Pro Gly Met Phe Asn 
            20                  25                  30          


Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn 
        35                  40                  45              


Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser Thr Arg Ala 
    50                  55                  60                  


Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro 
65                  70                  75                  80  


Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu 
                85                  90                  95      


Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn Gln His 
            100                 105                 110         


Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala 
        115                 120                 125             


Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro Gly 
    130                 135                 140                 


Leu Leu Gln Trp Val Lys Phe Trp 
145                 150         


<210>  362
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Arg Asn Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe 
1               5                   10                  15      


Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile 
            20                  25                  30          


Asn Lys Asn Gln Val Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe 
        35                  40                  45              


Ser Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp 
    50                  55                  60                  


Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala 
65                  70                  75                  80  


Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr 
                85                  90                  95      


Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val 
            100                 105                 110         


Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp 
        115                 120                 125             


Val Lys Phe Trp 
    130         


<210>  363
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Arg Asn Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe 
1               5                   10                  15      


Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile 
            20                  25                  30          


Asn Lys Asn Gln Val Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe 
        35                  40                  45              


Ser Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp 
    50                  55                  60                  


Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala 
65                  70                  75                  80  


Gly Arg Asp Asp Gln Pro Gly Ala Gly Trp Gln Glu Val Ala Ala Val 
                85                  90                  95      


Thr Ser Lys Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr 
            100                 105                 110         


Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro 
        115                 120                 125             


Ser Ser Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys 
    130                 135                 140                 


Phe Trp 
145     


<210>  364
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser 
            20                  25                  30          


Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln 
        35                  40                  45              


Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala 
    50                  55                  60                  


Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr 
65                  70                  75                  80  


Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys 
                85                  90                  95      


Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val 
            100                 105                 110         


Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
        115                 120             


<210>  365
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser 
            20                  25                  30          


Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln 
        35                  40                  45              


Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala 
    50                  55                  60                  


Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Pro Gly Ala Gly 
65                  70                  75                  80  


Trp Gln Glu Val Ala Ala Val Thr Ser Lys Asn Tyr Asn Tyr Asn Gln 
                85                  90                  95      


His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro 
            100                 105                 110         


Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro 
        115                 120                 125             


Gly Leu Leu Gln Trp Val Lys Phe Trp 
    130                 135         


<210>  366
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Asn Met Lys Pro Ala Thr Ala Ser Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Ala Trp Thr Gln Gly Ser His Gly Trp Gly Ala Asp Ala Ser 
            20                  25                  30          


Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn 
        35                  40                  45              


Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr 
    50                  55                  60                  


Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                85                  90  


<210>  367
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu 
                85                  90                  95      


Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
        115                 120                 125             


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
    130                 135             


<210>  368
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala 
        115                 120 


<210>  369
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  370
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Ala Gly Asp Val 
        435         


<210>  371
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  372
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser 
1               5                   10                  15      


Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg Ile His 
            20                  25                  30          


Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gln Asp 
        35                  40                  45              


Phe Lys Leu Asp Phe Gly Asn Ser Gln Gly Lys Thr Ser Gln Thr Trp 
    50                  55                  60                  


His Gly Gly Ile Ala Thr Ile Phe Gln Ser Pro Gly Asp Glu Val Trp 
65                  70                  75                  80  


Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu 
                85                  90                  95      


Gln Glu Gly Val Lys Ser Gly Met Tyr Val Val Ile Glu Val Lys Val 
            100                 105                 110         


Ala Thr Gln Glu Gly Lys Glu Ile Thr Cys Arg Ser Tyr Leu Met Thr 
        115                 120                 125             


Asn Tyr Glu Ser Ala Pro Pro Ser Pro Gln Tyr Lys Lys Ile Ile Cys 
    130                 135                 140                 


Met Gly Ala Lys Glu Asn Gly Leu Pro Leu Glu Tyr Gln Glu Lys Leu 
145                 150                 155                 160 


Lys Ala Ile Glu Pro Asn Asp Tyr Thr Gly Lys Val Ser Glu Glu Ile 
                165                 170                 175     


Glu Asp Ile Ile Lys Lys Gly Glu Thr Gln Thr Leu 
            180                 185             


<210>  373
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser 
1               5                   10                  15      


Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg Ile His 
            20                  25                  30          


Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gln Asp 
        35                  40                  45              


Phe Lys Leu Asp Phe Gly Asn Ser Gln Gly Lys Thr Ser Gln Thr Trp 
    50                  55                  60                  


His Gly Gly Ile Ala Thr Ile Phe Gln Ser Pro Gly Asp Glu Val Trp 
65                  70                  75                  80  


Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu 
                85                  90                  95      


Leu Phe Ala Trp Val Gln Lys Lys Met Val Cys Arg Trp Ser Ile Lys 
            100                 105                 110         


Arg Ser 
        


<210>  374
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  375
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Pro Arg Tyr Thr Val His Val Arg Gly Glu Trp Leu Ala Val Pro 
1               5                   10                  15      


Cys Gln Asp Ala Gln Leu Thr Val Gly Trp Leu Gly Arg Glu Ala Val 
            20                  25                  30          


Arg Arg Tyr Ile Lys Asn Lys Pro Asp Asn Gly Gly Phe Thr Ser Val 
        35                  40                  45              


Asp Asp Ala His Phe Leu Val Arg Arg Cys Lys Gly Leu Gly Leu Leu 
    50                  55                  60                  


Asp Asn Glu Asp Arg Leu Glu Val Ala Leu Glu Asn Asn Glu Phe Val 
65                  70                  75                  80  


Glu Val Val Ile Glu Gly Asp Ala Met Ser Pro Asp Phe Ile Pro Ser 
                85                  90                  95      


Gln Pro Glu Gly Val Tyr Leu Tyr Ser Lys Tyr Arg Glu Pro Glu Lys 
            100                 105                 110         


Tyr Ile Glu Leu Asp Gly Asp Arg Leu Thr Thr Glu Asp Leu Val Asn 
        115                 120                 125             


Leu Gly Lys Gly Arg Tyr Lys Ile Lys Leu Thr Pro Thr Ala Glu Lys 
    130                 135                 140                 


Arg Val Gln Lys Ser Arg Glu Val Ile Asp Ser Ile Ile Lys Glu Lys 
145                 150                 155                 160 


Thr Val Val Tyr Gly Ile Thr Thr Gly Phe Gly Lys Phe Ala Arg Thr 
                165                 170                 175     


Val Ile Pro Ile Asn Lys Leu Gln Glu Leu Gln Val Asn Leu Val Arg 
            180                 185                 190         


Ser His Ser Ser Gly Val Gly Lys Pro Leu Ser Pro Glu Arg Cys Arg 
        195                 200                 205             


Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly 
    210                 215                 220                 


Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser 
225                 230                 235                 240 


Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp 
                245                 250                 255     


Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys 
            260                 265                 270         


Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu 
        275                 280                 285             


Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala 
    290                 295                 300                 


Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val 
305                 310                 315                 320 


Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu 
                325                 330                 335     


Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile 
            340                 345                 350         


His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe 
        355                 360                 365             


Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser 
    370                 375                 380                 


His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys 
385                 390                 395                 400 


Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn 
                405                 410                 415     


Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe 
            420                 425                 430         


Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr 
        435                 440                 445             


Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala 
    450                 455                 460                 


Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser 
465                 470                 475                 480 


Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe 
                485                 490                 495     


Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala 
            500                 505                 510         


Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr 
        515                 520                 525             


Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg 
    530                 535                 540                 


Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala 
545                 550                 555                 560 


Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu 
                565                 570                 575     


Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys 
            580                 585                 590         


Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu 
        595                 600                 605             


Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg 
    610                 615                 620                 


Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser 
625                 630                 635                 640 


Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp 
                645                 650                 655     


Leu 
    


<210>  376
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  376

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210>  377
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  377

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Glu Gly Glu Val Ser Ala Asp Glu Glu Gly Phe Glu Asn Leu Trp Ala 
        435                 440                 445             


Thr Ala Ser Thr Phe Ile Val Leu Phe Leu Leu Ser Leu Phe Tyr Ser 
    450                 455                 460                 


Thr Thr Val Thr Leu Phe Lys Val Lys 
465                 470             


<210>  378
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Asp Pro Ala Gly Ser 
            20                  25                  30          


Pro Leu Glu Pro Gly Pro Ser Leu Pro Thr Met Asn Phe Val His Thr 
        35                  40                  45              


Ser Pro Lys Val Lys Asn Leu Asn Pro Lys Lys Phe Ser Ile His Asp 
    50                  55                  60                  


Gln Asp His Lys Val Leu Val Leu Asp Ser Gly Asn Leu Ile Ala Val 
65                  70                  75                  80  


Pro Asp Lys Asn Tyr Ile Arg Pro Glu Ile Phe Phe Ala Leu Ala Ser 
                85                  90                  95      


Ser Leu Ser Ser Ala Ser Ala Glu Lys Gly Ser Pro Ile Leu Leu Gly 
            100                 105                 110         


Val Ser Lys Gly Glu Phe Cys Leu Tyr Cys Asp Lys Asp Lys Gly Gln 
        115                 120                 125             


Ser His Pro Ser Leu Gln Leu Lys Lys Glu Lys Leu Met Lys Leu Ala 
    130                 135                 140                 


Ala Gln Lys Glu Ser Ala Arg Arg Pro Phe Ile Phe Tyr Arg Ala Gln 
145                 150                 155                 160 


Val Gly Ser Trp Asn Met Leu Glu Ser Ala Ala His Pro Gly Trp Phe 
                165                 170                 175     


Ile Cys Thr Ser Cys Asn Cys Asn Glu Pro Val Gly Val Thr Asp Lys 
            180                 185                 190         


Phe Glu Asn Arg Lys His Ile Glu Phe Ser Phe Gln Pro Val Cys Lys 
        195                 200                 205             


Ala Glu Met Ser Pro Ser Glu Val Ser Asp 
    210                 215             


<210>  379
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Asp Pro Ala Gly Ser 
            20                  25                  30          


Pro Leu Glu Pro Gly Pro Ser Leu Pro Thr Met Asn Phe Val His Thr 
        35                  40                  45              


Lys Ile Phe Phe Ala Leu Ala Ser Ser Leu Ser Ser Ala Ser Ala Glu 
    50                  55                  60                  


Lys Gly Ser Pro Ile Leu Leu Gly Val Ser Lys Gly Glu Phe Cys Leu 
65                  70                  75                  80  


Tyr Cys Asp Lys Asp Lys Gly Gln Ser His Pro Ser Leu Gln Leu Lys 
                85                  90                  95      


Lys Glu Lys Leu Met Lys Leu Ala Ala Gln Lys Glu Ser Ala Arg Arg 
            100                 105                 110         


Pro Phe Ile Phe Tyr Arg Ala Gln Val Gly Ser Trp Asn Met Leu Glu 
        115                 120                 125             


Ser Ala Ala His Pro Gly Trp Phe Ile Cys Thr Ser Cys Asn Cys Asn 
    130                 135                 140                 


Glu Pro Val Gly Val Thr Asp Lys Phe Glu Asn Arg Lys His Ile Glu 
145                 150                 155                 160 


Phe Ser Phe Gln Pro Val Cys Lys Ala Glu Met Ser Pro Ser Glu Val 
                165                 170                 175     


Ser Asp 
        


<210>  380
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Asp Pro Ala Gly Ser 
            20                  25                  30          


Pro Leu Glu Pro Gly Pro Ser Leu Pro Thr Met Asn Phe Val His Thr 
        35                  40                  45              


Lys Ile Phe Phe Ala Leu Ala Ser Ser Leu Ser Ser Ala Ser Ala Glu 
    50                  55                  60                  


Lys Gly Ser Pro Ile Leu Leu Gly Val Ser Lys Gly Glu Phe Cys Leu 
65                  70                  75                  80  


Tyr Cys Asp Lys Asp Lys Gly Gln Ser His Pro Ser Leu Gln Leu Lys 
                85                  90                  95      


Lys Glu Lys Leu Met Lys Leu Ala Ala Gln Lys Glu Ser Ala Arg Arg 
            100                 105                 110         


Pro Phe Ile Phe Tyr Arg Ala Gln Val Gly Ser Trp Asn Met Leu Glu 
        115                 120                 125             


Ser Ala Ala His Pro Gly Trp Phe Ile Cys Thr Ser Cys Asn Cys Asn 
    130                 135                 140                 


Glu Pro Val Gly Val Thr Asp Lys Phe Glu Asn Arg Lys His Ile Glu 
145                 150                 155                 160 


Phe Ser Phe Gln Pro Val Cys Lys Ala Glu Met Ser Pro Ser Glu Val 
                165                 170                 175     


Ser Asp 
        


<210>  381
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Gly Pro Lys Val Lys 
            20                  25                  30          


Asn Leu Asn Pro Lys Lys Phe Ser Ile His Asp Gln Asp His Lys Val 
        35                  40                  45              


Leu Val Leu Asp Ser Gly Asn Leu Ile Ala Val Pro Asp Lys Asn Tyr 
    50                  55                  60                  


Ile Arg Pro Glu Ile Phe Phe Ala Leu Ala Ser Ser Leu Ser Ser Ala 
65                  70                  75                  80  


Ser Ala Glu Lys Gly Ser Pro Ile Leu Leu Gly Val Ser Lys Gly Glu 
                85                  90                  95      


Phe Cys Leu Tyr Cys Asp Lys Asp Lys Gly Gln Ser His Pro Ser Leu 
            100                 105                 110         


Gln Leu Lys Lys Glu Lys Leu Met Lys Leu Ala Ala Gln Lys Glu Ser 
        115                 120                 125             


Ala Arg Arg Pro Phe Ile Phe Tyr Arg Ala Gln Val Gly Ser Trp Asn 
    130                 135                 140                 


Met Leu Glu Ser Ala Ala His Pro Gly Trp Phe Ile Cys Thr Ser Cys 
145                 150                 155                 160 


Asn Cys Asn Glu Pro Val Gly Val Thr Asp Lys Phe Glu Asn Arg Lys 
                165                 170                 175     


His Ile Glu Phe Ser Phe Gln Pro Val Cys Lys Ala Glu Met Ser Pro 
            180                 185                 190         


Ser Glu Val Ser Asp 
        195         


<210>  382
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Glu Ile Phe Phe Ala 
            20                  25                  30          


Leu Ala Ser Ser Leu Ser Ser Ala Ser Ala Glu Lys Gly Ser Pro Ile 
        35                  40                  45              


Leu Leu Gly Val Ser Lys Gly Glu Phe Cys Leu Tyr Cys Asp Lys Asp 
    50                  55                  60                  


Lys Gly Gln Ser His Pro Ser Leu Gln Leu Lys Lys Glu Lys Leu Met 
65                  70                  75                  80  


Lys Leu Ala Ala Gln Lys Glu Ser Ala Arg Arg Pro Phe Ile Phe Tyr 
                85                  90                  95      


Arg Ala Gln Val Gly Ser Trp Asn Met Leu Glu Ser Ala Ala His Pro 
            100                 105                 110         


Gly Trp Phe Ile Cys Thr Ser Cys Asn Cys Asn Glu Pro Val Gly Val 
        115                 120                 125             


Thr Asp Lys Phe Glu Asn Arg Lys His Ile Glu Phe Ser Phe Gln Pro 
    130                 135                 140                 


Val Cys Lys Ala Glu Met Ser Pro Ser Glu Val Ser Asp 
145                 150                 155         


<210>  383
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Lys Pro Leu Leu Leu Ala Val Ser Leu Gly Leu Ile Ala Ala Leu 
1               5                   10                  15      


Gln Ala His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser 
            20                  25                  30          


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu 
        35                  40                  45              


Met Asn Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
    50                  55                  60                  


Gly Asn Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln 
65                  70                  75                  80  


Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
                85                  90                  95      


Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys 
            100                 105                 110         


Asp His Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val 
        115                 120                 125             


Arg Gly Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala 
    130                 135                 140                 


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
145                 150                 155                 160 


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
                165                 170                 175     


<210>  384
<211>  1265
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Ser Pro Ala Leu Gln Asp Leu Ser Gln Pro Glu Gly Leu Lys Lys 
1               5                   10                  15      


Thr Leu Arg Asp Glu Ile Asn Ala Ile Leu Gln Lys Arg Ile Met Val 
            20                  25                  30          


Leu Asp Gly Gly Met Gly Thr Met Ile Gln Arg Glu Lys Leu Asn Glu 
        35                  40                  45              


Glu His Phe Arg Gly Gln Glu Phe Lys Asp His Ala Arg Pro Leu Lys 
    50                  55                  60                  


Gly Asn Asn Asp Ile Leu Ser Ile Thr Gln Pro Asp Val Ile Tyr Gln 
65                  70                  75                  80  


Ile His Lys Glu Tyr Leu Leu Ala Gly Ala Asp Ile Ile Glu Thr Asn 
                85                  90                  95      


Thr Phe Ser Ser Thr Ser Ile Ala Gln Ala Asp Tyr Gly Leu Glu His 
            100                 105                 110         


Leu Ala Tyr Arg Met Asn Met Cys Ser Ala Gly Val Ala Arg Lys Ala 
        115                 120                 125             


Ala Glu Glu Val Thr Leu Gln Thr Gly Ile Lys Arg Phe Val Ala Gly 
    130                 135                 140                 


Ala Leu Gly Pro Thr Asn Lys Thr Leu Ser Val Ser Pro Ser Val Glu 
145                 150                 155                 160 


Arg Pro Asp Tyr Arg Asn Ile Thr Phe Asp Glu Leu Val Glu Ala Tyr 
                165                 170                 175     


Gln Glu Gln Ala Lys Gly Leu Leu Asp Gly Gly Val Asp Ile Leu Leu 
            180                 185                 190         


Ile Glu Thr Ile Phe Asp Thr Ala Asn Ala Lys Ala Ala Leu Phe Ala 
        195                 200                 205             


Leu Gln Asn Leu Phe Glu Glu Lys Tyr Ala Pro Arg Pro Ile Phe Ile 
    210                 215                 220                 


Ser Gly Thr Ile Val Asp Lys Ser Gly Arg Thr Leu Ser Gly Gln Thr 
225                 230                 235                 240 


Gly Glu Gly Phe Val Ile Ser Val Ser His Gly Glu Pro Leu Cys Ile 
                245                 250                 255     


Gly Leu Asn Cys Ala Leu Gly Ala Ala Glu Met Arg Pro Phe Ile Glu 
            260                 265                 270         


Ile Ile Gly Lys Cys Thr Thr Ala Tyr Val Leu Cys Tyr Pro Asn Ala 
        275                 280                 285             


Gly Leu Pro Asn Thr Phe Gly Asp Tyr Asp Glu Thr Pro Ser Met Met 
    290                 295                 300                 


Ala Lys His Leu Lys Asp Phe Ala Met Asp Gly Leu Val Asn Ile Val 
305                 310                 315                 320 


Gly Gly Cys Cys Gly Ser Thr Pro Asp His Ile Arg Glu Ile Ala Glu 
                325                 330                 335     


Ala Val Lys Asn Cys Lys Pro Arg Val Pro Pro Ala Thr Ala Phe Glu 
            340                 345                 350         


Gly His Met Leu Leu Ser Gly Leu Glu Pro Phe Arg Ile Gly Pro Tyr 
        355                 360                 365             


Thr Asn Phe Val Asn Ile Gly Glu Arg Cys Asn Val Ala Gly Ser Arg 
    370                 375                 380                 


Lys Phe Ala Lys Leu Ile Met Ala Gly Asn Tyr Glu Glu Ala Leu Cys 
385                 390                 395                 400 


Val Ala Lys Val Gln Val Glu Met Gly Ala Gln Val Leu Asp Val Asn 
                405                 410                 415     


Met Asp Asp Gly Met Leu Asp Gly Pro Ser Ala Met Thr Arg Phe Cys 
            420                 425                 430         


Asn Leu Ile Ala Ser Glu Pro Asp Ile Ala Lys Val Pro Leu Cys Ile 
        435                 440                 445             


Asp Ser Ser Asn Phe Ala Val Ile Glu Ala Gly Leu Lys Cys Cys Gln 
    450                 455                 460                 


Gly Lys Cys Ile Val Asn Ser Ile Ser Leu Lys Glu Gly Glu Asp Asp 
465                 470                 475                 480 


Phe Leu Glu Lys Ala Arg Lys Ile Lys Lys Tyr Gly Ala Ala Met Val 
                485                 490                 495     


Val Met Ala Phe Asp Glu Glu Gly Gln Ala Thr Glu Thr Asp Thr Lys 
            500                 505                 510         


Ile Arg Val Cys Thr Arg Ala Tyr His Leu Leu Val Lys Lys Leu Gly 
        515                 520                 525             


Phe Asn Pro Asn Asp Ile Ile Phe Asp Pro Asn Ile Leu Thr Ile Gly 
    530                 535                 540                 


Thr Gly Met Glu Glu His Asn Leu Tyr Ala Ile Asn Phe Ile His Ala 
545                 550                 555                 560 


Thr Lys Val Ile Lys Glu Thr Leu Pro Gly Ala Arg Ile Ser Gly Gly 
                565                 570                 575     


Leu Ser Asn Leu Ser Phe Ser Phe Arg Gly Met Glu Ala Ile Arg Glu 
            580                 585                 590         


Ala Met His Gly Val Phe Leu Tyr His Ala Ile Lys Ser Gly Met Asp 
        595                 600                 605             


Met Gly Ile Val Asn Ala Gly Asn Leu Pro Val Tyr Asp Asp Ile His 
    610                 615                 620                 


Lys Glu Leu Leu Gln Leu Cys Glu Asp Leu Ile Trp Asn Lys Asp Pro 
625                 630                 635                 640 


Glu Ala Thr Glu Lys Leu Leu Arg Tyr Ala Gln Thr Gln Gly Thr Gly 
                645                 650                 655     


Gly Lys Lys Val Ile Gln Thr Asp Glu Trp Arg Asn Gly Pro Val Glu 
            660                 665                 670         


Glu Arg Leu Glu Tyr Ala Leu Val Lys Gly Ile Glu Lys His Ile Ile 
        675                 680                 685             


Glu Asp Thr Glu Glu Ala Arg Leu Asn Gln Lys Lys Tyr Pro Arg Pro 
    690                 695                 700                 


Leu Asn Ile Ile Glu Gly Pro Leu Met Asn Gly Met Lys Ile Val Gly 
705                 710                 715                 720 


Asp Leu Phe Gly Ala Gly Lys Met Phe Leu Pro Gln Val Ile Lys Ser 
                725                 730                 735     


Ala Arg Val Met Lys Lys Ala Val Gly His Leu Ile Pro Phe Met Glu 
            740                 745                 750         


Lys Glu Arg Glu Glu Thr Arg Val Leu Asn Gly Thr Val Glu Glu Glu 
        755                 760                 765             


Asp Pro Tyr Gln Gly Thr Ile Val Leu Ala Thr Val Lys Gly Asp Val 
    770                 775                 780                 


His Asp Ile Gly Lys Asn Ile Val Gly Val Val Leu Gly Cys Asn Asn 
785                 790                 795                 800 


Phe Arg Val Ile Asp Leu Gly Val Met Thr Pro Cys Asp Lys Ile Leu 
                805                 810                 815     


Lys Ala Ala Leu Asp His Lys Ala Asp Ile Ile Gly Leu Ser Gly Leu 
            820                 825                 830         


Ile Thr Pro Ser Leu Asp Glu Met Ile Phe Val Ala Lys Glu Met Glu 
        835                 840                 845             


Arg Leu Ala Ile Arg Ile Pro Leu Leu Ile Gly Gly Ala Thr Thr Ser 
    850                 855                 860                 


Lys Thr His Thr Ala Val Lys Ile Ala Pro Arg Tyr Ser Ala Pro Val 
865                 870                 875                 880 


Ile His Val Leu Asp Ala Ser Lys Ser Val Val Val Cys Ser Gln Leu 
                885                 890                 895     


Leu Asp Glu Asn Leu Lys Asp Glu Tyr Phe Glu Glu Ile Met Glu Glu 
            900                 905                 910         


Tyr Glu Asp Ile Arg Gln Asp His Tyr Glu Ser Leu Lys Glu Arg Arg 
        915                 920                 925             


Tyr Leu Pro Leu Ser Gln Ala Arg Lys Ser Gly Phe Gln Met Asp Trp 
    930                 935                 940                 


Leu Ser Glu Pro His Pro Val Lys Pro Thr Phe Ile Gly Thr Gln Val 
945                 950                 955                 960 


Phe Glu Asp Tyr Asp Leu Gln Lys Leu Val Asp Tyr Ile Asp Trp Lys 
                965                 970                 975     


Pro Phe Phe Asp Val Trp Gln Leu Arg Gly Lys Tyr Pro Asn Arg Gly 
            980                 985                 990         


Phe Pro Lys Ile Phe Asn Asp Lys  Thr Val Gly Gly Glu  Ala Arg Lys 
        995                 1000                 1005             


Val Tyr  Asp Asp Ala His Asn  Met Leu Asn Thr Leu  Ile Ser Gln 
    1010                 1015                 1020             


Lys Lys  Leu Arg Ala Arg Gly  Val Val Gly Phe Trp  Pro Ala Gln 
    1025                 1030                 1035             


Ser Ile  Gln Asp Asp Ile His  Leu Tyr Ala Glu Ala  Ala Val Pro 
    1040                 1045                 1050             


Gln Ala  Ala Glu Pro Ile Ala  Thr Phe Tyr Gly Leu  Arg Gln Gln 
    1055                 1060                 1065             


Ala Glu  Lys Asp Ser Ala Ser  Thr Glu Pro Tyr Tyr  Cys Leu Ser 
    1070                 1075                 1080             


Asp Phe  Ile Ala Pro Leu His  Ser Gly Ile Arg Asp  Tyr Leu Gly 
    1085                 1090                 1095             


Leu Phe  Ala Val Ala Cys Phe  Gly Val Glu Glu Leu  Ser Lys Ala 
    1100                 1105                 1110             


Tyr Glu  Asp Asp Gly Asp Asp  Tyr Ser Ser Ile Met  Val Lys Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Leu Ala Glu  Ala Phe Ala Glu Glu  Leu His Glu 
    1130                 1135                 1140             


Arg Val  Arg Arg Glu Leu Trp  Ala Tyr Cys Gly Ser  Glu Gln Leu 
    1145                 1150                 1155             


Asp Val  Ala Asp Leu Arg Arg  Leu Arg Tyr Lys Gly  Ile Arg Pro 
    1160                 1165                 1170             


Ala Pro  Gly Tyr Pro Ser Gln  Pro Asp His Thr Glu  Lys Leu Thr 
    1175                 1180                 1185             


Met Trp  Arg Leu Ala Asp Ile  Glu Gln Ser Thr Gly  Ile Arg Leu 
    1190                 1195                 1200             


Thr Glu  Ser Leu Ala Met Ala  Pro Ala Ser Ala Val  Ser Gly Leu 
    1205                 1210                 1215             


Tyr Phe  Ser Asn Leu Lys Ser  Lys Tyr Phe Ala Val  Gly Lys Ile 
    1220                 1225                 1230             


Ser Lys  Asp Gln Val Glu Asp  Tyr Ala Leu Arg Lys  Asn Ile Ser 
    1235                 1240                 1245             


Val Ala  Glu Val Glu Lys Trp  Leu Gly Pro Ile Leu  Gly Tyr Asp 
    1250                 1255                 1260             


Thr Asp  
    1265 


<210>  385
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      


Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         


Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             


Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 


Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 


Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     


Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         


Tyr Phe Ser Lys His Asn 
        195             


<210>  386
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  387
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ser Pro Trp Lys Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu 
1               5                   10                  15      


Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val Met 
            20                  25                  30          


Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His 
        35                  40                  45              


Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val 
    50                  55                  60                  


Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser 
65                  70                  75                  80  


Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu 
                85                  90                  95      


Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly 
            100                 105                 110         


Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu 
        115                 120                 125             


Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr 
    130                 135                 140                 


Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser 
145                 150                 155                 160 


Ala Pro Glu Gly Arg Thr Ser Leu Val Pro Pro Ala Thr Ala Ala Pro 
                165                 170                 175     


Ala Leu Cys His Arg Val Gly His His Arg Leu Leu Pro Thr Trp Leu 
            180                 185                 190         


Ala Leu Gln Pro 
        195     


<210>  388
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Ser Ser Ser Tyr Trp Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr 
1               5                   10                  15      


Gln Gln Leu Pro Glu Val Leu Gln Cys Gln Pro Gln His Tyr His Cys 
            20                  25                  30          


Tyr His Gln Ser Ser Gln Ala Gln Gln Pro Pro Glu Lys Asn Val Val 
        35                  40                  45              


Tyr Glu Arg Val Arg Thr Tyr Ser Gly Pro Met Asn Lys Val Val Gln 
    50                  55                  60                  


Ala Leu Asp Pro Phe Asn Ser Arg Glu Val Leu Ser Pro Leu Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Tyr Gln Asn Leu Val Trp Ser Asp His Ser Gln Glu Leu 
                85                  90                  95      


His Ser Pro Thr Leu Lys Ile Ser Thr Cys Ala Pro Ser Thr Leu His 
            100                 105                 110         


Ile Thr Gln Asn Thr Glu Gln Glu Leu His Ser Pro Thr Val Lys Leu 
        115                 120                 125             


Thr Thr Tyr Pro Gln Thr Thr Ile Arg Lys Tyr Val Val Gln Asn Pro 
    130                 135                 140                 


Glu Gln Glu Pro Leu Ser Gln Phe Leu Arg Gly Ser His Phe Phe Pro 
145                 150                 155                 160 


Gly Asn Asn Val Ile Tyr Glu Lys Thr Ile Arg Lys Val Glu Lys Leu 
                165                 170                 175     


Asn Thr Asp Gln Gly Cys His Pro Gln Ala Gln Cys His His His Ile 
            180                 185                 190         


Ile Gln Gln Pro Gln Val Ile His Ser Ala His Trp Gln Gln Pro Asp 
        195                 200                 205             


Ser Ser Gln Gln Ile Gln Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr 
    210                 215                 220                 


His Ile Gly Asn Glu Leu Cys His Ser Gly Ser Ser Gln Ile Cys Glu 
225                 230                 235                 240 


Gln Val Ile Ile Gln Asp Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr 
                245                 250                 255     


Phe Gly Glu Leu Leu Ala Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr 
            260                 265                 270         


His Cys Leu Leu Glu His Leu Gln Arg Ile Gly Gly Ser Lys Gln Asp 
        275                 280                 285             


Phe Glu Ser Thr Asp Glu Ser Glu Asp Ile Glu Ser Leu Ile Pro Lys 
    290                 295                 300                 


Gly Leu Ser Glu Phe Thr Lys Gln Gln Ile Arg Tyr Ile Leu Gln Met 
305                 310                 315                 320 


Arg Gly Met Ser Asp Lys Ser Leu Arg Leu Val Leu Ser Thr Phe Ser 
                325                 330                 335     


Asn Ile Arg Glu Glu Leu Gly His Leu Gln Asn Asp Met Thr Ser Leu 
            340                 345                 350         


Glu Asn Asp Lys Met Arg Leu Glu Lys Asp Leu Ser Phe Lys Asp Thr 
        355                 360                 365             


Gln Leu Lys Glu Tyr Glu Glu Leu Leu Ala Ser Val Arg Ala Asn Asn 
    370                 375                 380                 


His Gln Gln Gln Gln Gly Leu Gln Asp Ser Ser Ser Lys Cys Gln Ala 
385                 390                 395                 400 


Leu Glu Glu Asn Asn Leu Ser Leu Arg His Thr Leu Ser Asp Met Glu 
                405                 410                 415     


Tyr Arg Leu Lys Glu Leu Glu Tyr Cys Lys Arg Asn Leu Glu Gln Glu 
            420                 425                 430         


Asn Gln Asn Leu Arg Met Gln Val Ser Glu Thr Cys Thr Gly Pro Met 
        435                 440                 445             


Leu Gln Ala Lys Met Asp Glu Ile Gly Asn His Tyr Thr Glu Met Val 
    450                 455                 460                 


Lys Asn Leu Arg Met Glu Lys Asp Arg Glu Ile Cys Arg Leu Arg Ser 
465                 470                 475                 480 


Gln Leu Asn Gln Tyr His Lys Asp Val Ser Lys Arg Glu Gly Ser Cys 
                485                 490                 495     


Ser Asp Phe Gln Phe Lys Leu His Glu Leu Thr Ser Leu Leu Glu Glu 
            500                 505                 510         


Lys Asp Ser Leu Ile Lys Arg Gln Ser Glu Glu Leu Ser Lys Leu Arg 
        515                 520                 525             


Gln Glu Ile Tyr Ser Ser His Asn Gln Pro Ser Thr Gly Gly Arg Thr 
    530                 535                 540                 


Thr Ile Thr Thr Lys Lys Tyr Arg Thr Gln Tyr Pro Ile Leu Gly Leu 
545                 550                 555                 560 


Leu Tyr Asp Asp Tyr Glu Tyr Ile Pro Pro Gly Ser Glu Thr Gln Thr 
                565                 570                 575     


Ile Val Ile Glu Lys Thr Glu Asp Lys Tyr Thr Cys Val Ser Ser Leu 
            580                 585                 590         


Gly His Phe 
        595 


<210>  389
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Ser Ser Ser Tyr Trp Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr 
1               5                   10                  15      


Gln Gln Leu Pro Glu Val Leu Gln Cys Gln Pro Gln His Tyr His Cys 
            20                  25                  30          


Tyr His Gln Ser Ser Gln Ala Gln Gln Pro Pro Glu Lys Asn Val Val 
        35                  40                  45              


Tyr Glu Arg Val Arg Thr Tyr Ser Gly Pro Met Asn Lys Val Val Gln 
    50                  55                  60                  


Ala Leu Asp Pro Phe Asn Ser Arg Glu Val Leu Ser Pro Leu Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Tyr Gln Asn Leu Val Trp Ser Asp His Ser Gln Glu Leu 
                85                  90                  95      


His Ser Pro Thr Leu Lys Ile Ser Thr Cys Ala Pro Ser Thr Leu His 
            100                 105                 110         


Ile Thr Gln Asn Thr Glu Gln Glu Leu His Ser Pro Thr Val Lys Leu 
        115                 120                 125             


Thr Thr Tyr Pro Gln Thr Thr Ile Arg Lys Tyr Val Val Gln Asn Pro 
    130                 135                 140                 


Glu Gln Glu Pro Leu Ser Gln Phe Leu Arg Gly Ser His Phe Phe Pro 
145                 150                 155                 160 


Gly Asn Asn Val Ile Tyr Glu Lys Thr Ile Arg Lys Val Glu Lys Leu 
                165                 170                 175     


Asn Thr Asp Gln Gly Cys His Pro Gln Ala Gln Cys His His His Ile 
            180                 185                 190         


Ile Gln Gln Pro Gln Val Ile His Ser Ala His Trp Gln Gln Pro Asp 
        195                 200                 205             


Ser Ser Gln Gln Ile Gln Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr 
    210                 215                 220                 


His Ile Gly Asn Glu Leu Cys His Ser Gly Ser Ser Gln Ile Cys Glu 
225                 230                 235                 240 


Gln Val Ile Ile Gln Asp Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr 
                245                 250                 255     


Phe Gly Glu Leu Leu Ala Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr 
            260                 265                 270         


His Cys Leu Leu Glu His Leu Gln Arg Ile Gly Gly Ser Lys Gln Asp 
        275                 280                 285             


Phe Glu Ser Thr Asp Glu Ser Glu Asp Ile Glu Ser Leu Ile Pro Lys 
    290                 295                 300                 


Gly Leu Ser Glu Phe Thr Lys Gln Gln Ile Arg Tyr Ile Leu Gln Met 
305                 310                 315                 320 


Arg Gly Met Ser Asp Lys Ser Leu Arg Leu Val Leu Ser Thr Phe Ser 
                325                 330                 335     


Asn Ile Arg Glu Glu Leu Gly His Leu Gln Asn Asp Met Thr Ser Leu 
            340                 345                 350         


Glu Asn Asp Lys Met Arg Leu Glu Lys Asp Leu Ser Phe Lys Asp Thr 
        355                 360                 365             


Gln Leu Lys Glu Tyr Glu Glu Leu Leu Ala Ser Val Arg Ala Asn Asn 
    370                 375                 380                 


His Gln Gln Gln Gln Gly Leu Gln Asp Ser Ser Ser Lys Cys Gln Ala 
385                 390                 395                 400 


Leu Glu Glu Asn Asn Leu Ser Leu Arg His Thr Leu Ser Asp Met Glu 
                405                 410                 415     


Tyr Arg Leu Lys Glu Leu Glu Tyr Cys Lys Arg Asn Leu Glu Gln Glu 
            420                 425                 430         


Asn Gln Asn Leu Arg Met Gln Val Ser Glu Thr Cys Thr Gly Pro Met 
        435                 440                 445             


Leu Gln Ala Lys Met Asp Glu Ile Gly Asn His Tyr Thr Glu Met Val 
    450                 455                 460                 


Lys Asn Leu Arg Met Glu Lys Asp Arg Glu Ile Cys Arg Leu Arg Ser 
465                 470                 475                 480 


Gln Leu Asn Gln Tyr His Lys Asp Val Ser Lys Arg Glu Gly Ser Cys 
                485                 490                 495     


Ser Asp Phe Gln Phe Lys Leu His Glu Leu Thr Ser Leu Leu Glu Glu 
            500                 505                 510         


Lys Asp Ser Leu Ile Lys Arg Gln Ser Glu Glu Leu Ser Lys Leu Arg 
        515                 520                 525             


Gln Glu Ile Tyr Ser Ser His Asn Gln Pro Ser Thr Gly Gly Arg Thr 
    530                 535                 540                 


Thr Ile Thr Thr Lys Lys Tyr Arg Thr Gln Tyr Pro Ile Leu Gly Leu 
545                 550                 555                 560 


Leu Tyr Asp Asp Tyr Glu Tyr Ile Pro Pro Gly Ser Glu Thr Gln Thr 
                565                 570                 575     


Ile Val Ile Glu Lys Thr Glu Asp Lys Tyr Thr Cys Pro 
            580                 585                 


<210>  390
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Ser Ser Ser Tyr Trp Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr 
1               5                   10                  15      


Gln Gln Leu Pro Glu Val Leu Gln Cys Gln Pro Gln His Tyr His Cys 
            20                  25                  30          


Tyr His Gln Ser Ser Gln Ala Gln Gln Pro Pro Glu Lys Asn Val Val 
        35                  40                  45              


Tyr Glu Arg Val Arg Thr Tyr Ser Gly Pro Met Asn Lys Val Val Gln 
    50                  55                  60                  


Ala Leu Asp Pro Phe Asn Ser Arg Glu Val Leu Ser Pro Leu Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Tyr Gln Asn Leu Val Trp Ser Asp His Ser Gln Glu Leu 
                85                  90                  95      


His Ser Pro Thr Leu Lys Ile Ser Thr Cys Ala Pro Ser Thr Leu His 
            100                 105                 110         


Ile Thr Gln Asn Thr Glu Gln Glu Leu His Ser Pro Thr Val Lys Leu 
        115                 120                 125             


Thr Thr Tyr Pro Gln Thr Thr Ile Arg Lys Tyr Val Val Gln Asn Pro 
    130                 135                 140                 


Glu Gln Glu Pro Leu Ser Gln Phe Leu Arg Gly Ser His Phe Phe Pro 
145                 150                 155                 160 


Gly Asn Asn Val Ile Tyr Glu Lys Thr Ile Arg Lys Val Glu Lys Leu 
                165                 170                 175     


Asn Thr Asp Gln Gly Cys His Pro Gln Ala Gln Cys His His His Ile 
            180                 185                 190         


Ile Gln Gln Pro Gln Val Ile His Ser Ala His Trp Gln Gln Pro Asp 
        195                 200                 205             


Ser Ser Gln Gln Ile Gln Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr 
    210                 215                 220                 


His Ile Gly Asn Glu Leu Cys His Ser Gly Ser Ser Gln Ile Cys Glu 
225                 230                 235                 240 


Gln Val Ile Ile Gln Asp Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr 
                245                 250                 255     


Phe Gly Glu Leu Leu Ala Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr 
            260                 265                 270         


His Cys Leu Leu Glu His Leu Gln Arg Ile Gly Arg Lys Gln Ser Leu 
        275                 280                 285             


Ser Ser Thr Tyr Thr Ile Arg His Gly Ile Gln Thr Lys Arg Thr Gly 
    290                 295                 300                 


Ile Leu 
305     


<210>  391
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Arg Arg Asp Asp Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Thr Asn Tyr Leu Ala Asp Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Thr Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210>  392
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ala Ala Leu Gly Val Gln Ser Ile Asn Trp Gln Thr Ala Phe Asn 
1               5                   10                  15      


Arg Gln Ala His His Thr Asp Lys Phe Ser Ser Gln Glu Leu Ile Leu 
            20                  25                  30          


Arg Arg Gly Gln Asn Phe Gln Val Leu Met Ile Met Asn Lys Gly Leu 
        35                  40                  45              


Gly Ser Asn Glu Arg Leu Glu Phe Ile Val Ser Thr Gly Pro Tyr Pro 
    50                  55                  60                  


Ser Glu Ser Ala Met Thr Lys Ala Val Phe Pro Leu Ser Asn Gly Ser 
65                  70                  75                  80  


Ser Gly Gly Trp Ser Ala Val Leu Gln Ala Ser Asn Gly Asn Thr Leu 
                85                  90                  95      


Thr Ile Ser Ile Ser Ser Pro Ala Ser Ala Pro Ile Gly Arg Tyr Thr 
            100                 105                 110         


Met Ala Leu Gln Ile Phe Ser Gln Gly Gly Ile Ser Ser Val Lys Leu 
        115                 120                 125             


Gly Thr Phe Ile Leu Leu Phe Asn Pro Trp Leu Asn Val Asp Ser Val 
    130                 135                 140                 


Phe Met Gly Asn His Ala Glu Arg Glu Glu Tyr Val Gln Glu Asp Ala 
145                 150                 155                 160 


Gly Ile Ile Phe Val Gly Ser Thr Asn Arg Ile Gly Met Ile Gly Trp 
                165                 170                 175     


Asn Phe Gly Gln Phe Glu Glu Asp Ile Leu Ser Ile Cys Leu Ser Ile 
            180                 185                 190         


Leu Asp Arg Ser Leu Asn Phe Arg Arg Asp Ala Ala Thr Asp Val Ala 
        195                 200                 205             


Ser Arg Asn Asp Pro Lys Tyr Val Gly Arg Val Leu Ser Ala Met Ile 
    210                 215                 220                 


Asn Ser Asn Asp Asp Asn Gly Val Leu Ala Gly Asn Trp Ser Gly Thr 
225                 230                 235                 240 


Tyr Thr Gly Gly Arg Asp Pro Arg Ser Trp Asn Gly Ser Val Glu Ile 
                245                 250                 255     


Leu Lys Asn Trp Lys Lys Ser Gly Phe Ser Pro Val Arg Tyr Gly Gln 
            260                 265                 270         


Cys Trp Val Phe Ala Gly Thr Leu Asn Thr Ala Leu Arg Ser Leu Gly 
        275                 280                 285             


Ile Pro Ser Arg Val Ile Thr Asn Phe Asn Ser Ala His Asp Thr Asp 
    290                 295                 300                 


Arg Asn Leu Ser Val Asp Val Tyr Tyr Asp Pro Met Gly Asn Pro Leu 
305                 310                 315                 320 


Asp Lys Gly Ser Asp Ser Val Trp Asn Phe His Val Trp Asn Glu Gly 
                325                 330                 335     


Trp Phe Val Arg Ser Asp Leu Gly Pro Ser Tyr Gly Gly Trp Gln Val 
            340                 345                 350         


Leu Asp Ala Thr Pro Gln Glu Arg Ser Gln Gly Val Phe Gln Cys Gly 
        355                 360                 365             


Pro Ala Ser Val Ile Gly Val Arg Glu Gly Asp Val Gln Leu Asn Phe 
    370                 375                 380                 


Asp Met Pro Phe Ile Phe Ala Glu Val Asn Ala Asp Arg Ile Thr Trp 
385                 390                 395                 400 


Leu Tyr Asp Asn Thr Thr Gly Lys Gln Trp Lys Asn Ser Val Asn Ser 
                405                 410                 415     


His Thr Ile Gly Arg Tyr Ile Ser Thr Lys Ala Val Gly Ser Asn Ala 
            420                 425                 430         


Arg Met Asp Val Thr Asp Lys Tyr Lys Tyr Pro Glu Gly Ser Asp Gln 
        435                 440                 445             


Glu Arg Gln Val Phe Gln Lys Ala Leu Gly Lys Leu Lys Pro Asn Thr 
    450                 455                 460                 


Pro Phe Ala Ala Thr Ser Ser Met Gly Leu Glu Thr Glu Glu Gln Glu 
465                 470                 475                 480 


Pro Ser Ile Ile Gly Lys Leu Lys Val Ala Gly Met Leu Ala Val Gly 
                485                 490                 495     


Lys Glu Val Asn Leu Val Leu Leu Leu Lys Asn Leu Ser Arg Asp Thr 
            500                 505                 510         


Lys Thr Val Thr Val Asn Met Thr Ala Trp Thr Ile Ile Tyr Asn Gly 
        515                 520                 525             


Thr Leu Val His Glu Val Trp Lys Asp Ser Ala Thr Met Ser Leu Asp 
    530                 535                 540                 


Pro Glu Glu Glu Ala Glu His Pro Ile Lys Ile Ser Tyr Ala Gln Tyr 
545                 550                 555                 560 


Glu Lys Tyr Leu Lys Ser Asp Asn Met Ile Arg Ile Thr Ala Val Cys 
                565                 570                 575     


Lys Val Pro Asp Glu Ser Glu Val Val Val Glu Arg Asp Ile Ile Leu 
            580                 585                 590         


Asp Asn Pro Thr Leu Thr Leu Glu Val Leu Asn Glu Ala Arg Val Arg 
        595                 600                 605             


Lys Pro Val Asn Val Gln Met Leu Phe Ser Asn Pro Leu Asp Glu Pro 
    610                 615                 620                 


Val Arg Asp Cys Val Leu Met Val Glu Gly Ser Gly Leu Leu Leu Gly 
625                 630                 635                 640 


Asn Leu Lys Ile Asp Val Pro Thr Leu Gly Pro Lys Glu Gly Ser Arg 
                645                 650                 655     


Val Arg Phe Asp Ile Leu Pro Ser Arg Ser Gly Thr Lys Gln Leu Leu 
            660                 665                 670         


Ala Asp Phe Ser Cys Asn Lys Phe Pro Ala Ile Lys Ala Met Leu Ser 
        675                 680                 685             


Ile Asp Val Ala Glu 
    690             


<210>  393
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  394
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Val Arg 
385                 390                 395                 400 


Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  395
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15      


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30          


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45              


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60                  


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80  


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95      


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110         


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125             


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140                 


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160 


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175     


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190         


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205             


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220                 


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240 


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255     


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270         


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285             


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300                 


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320 


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335     


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350         


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365             


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380                 


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400 


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415     


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430         


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445             


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460                 


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480 


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495     


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510         


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525             


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540                 


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575     


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590         


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605             


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620                 


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640 


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655     


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670         


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685             


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700                 


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720 


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735     


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750         


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765             


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780                 


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800 


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815     


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830         


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845             


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860                 


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880 


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895     


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910         


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925             


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940                 


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960 


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975     


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990         


Arg Phe Ser Ile Arg Asn Thr Lys  Val Lys Lys Gly Gln  Lys Gly Asn 
        995                 1000                 1005             


Pro Lys  Gly Arg Gln Asn Glu  Arg Val Val Ile Gln  Tyr His Tyr 
    1010                 1015                 1020             


Thr Gln  Trp Pro Asp Met Gly  Val Pro Glu Tyr Ala  Leu Pro Val 
    1025                 1030                 1035             


Leu Thr  Phe Val Arg Arg Ser  Ser Ala Ala Arg Met  Pro Glu Thr 
    1040                 1045                 1050             


Gly Pro  Val Leu Val His Cys  Ser Ala Gly Val Gly  Arg Thr Gly 
    1055                 1060                 1065             


Thr Tyr  Ile Val Ile Asp Ser  Met Leu Gln Gln Ile  Lys Asp Lys 
    1070                 1075                 1080             


Ser Thr  Val Asn Val Leu Gly  Phe Leu Lys His Ile  Arg Thr Gln 
    1085                 1090                 1095             


Arg Asn  Tyr Leu Val Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His 
    1100                 1105                 1110             


Asp Ala  Leu Leu Glu Ala Ile  Leu Gly Lys Glu Thr  Glu Val Ser 
    1115                 1120                 1125             


Ser Asn  Gln Leu His Ser Tyr  Val Asn Ser Ile Leu  Ile Pro Gly 
    1130                 1135                 1140             


Val Gly  Gly Lys Thr Arg Leu  Glu Lys Gln Phe Lys  Leu Val Thr 
    1145                 1150                 1155             


Gln Cys  Asn Ala Lys Tyr Val  Glu Cys Phe Ser Ala  Gln Lys Glu 
    1160                 1165                 1170             


Cys Asn  Lys Glu Lys Asn Arg  Asn Ser Ser Val Val  Pro Ser Glu 
    1175                 1180                 1185             


Arg Ala  Arg Val Gly Leu Ala  Pro Leu Pro Gly Met  Lys Gly Thr 
    1190                 1195                 1200             


Asp Tyr  Ile Asn Ala Ser Tyr  Ile Met Gly Tyr Tyr  Arg Ser Asn 
    1205                 1210                 1215             


Glu Phe  Ile Ile Thr Gln His  Pro Leu Pro His Thr  Thr Lys Asp 
    1220                 1225                 1230             


Phe Trp  Arg Met Ile Trp Asp  His Asn Ala Gln Ile  Ile Val Met 
    1235                 1240                 1245             


Leu Pro  Asp Asn Gln Ser Leu  Ala Glu Asp Glu Phe  Val Tyr Trp 
    1250                 1255                 1260             


Pro Ser  Arg Glu Glu Ser Met  Asn Cys Glu Ala Phe  Thr Val Thr 
    1265                 1270                 1275             


Leu Ile  Ser Lys Asp Arg Leu  Cys Leu Ser Asn Glu  Glu Gln Ile 
    1280                 1285                 1290             


Ile Ile  His Asp Phe Ile Leu  Glu Ala Thr Gln Asp  Asp Tyr Val 
    1295                 1300                 1305             


Leu Glu  Val Arg His Phe Gln  Cys Pro Lys Trp Pro  Asn Pro Asp 
    1310                 1315                 1320             


Ala Pro  Ile Ser Ser Thr Phe  Glu Leu Ile Asn Val  Ile Lys Glu 
    1325                 1330                 1335             


Glu Ala  Leu Thr Arg Asp Gly  Pro Thr Ile Val His  Asp Glu Tyr 
    1340                 1345                 1350             


Gly Ala  Val Ser Ala Gly Met  Leu Cys Ala Leu Thr  Thr Leu Ser 
    1355                 1360                 1365             


Gln Gln  Leu Glu Asn Glu Asn  Ala Val Asp Val Phe  Gln Val Ala 
    1370                 1375                 1380             


Lys Met  Ile Asn Leu Met Arg  Pro Gly Val Phe Thr  Asp Ile Glu 
    1385                 1390                 1395             


Gln Tyr  Gln Phe Ile Tyr Lys  Ala Met Leu Ser Leu  Val Ser Thr 
    1400                 1405                 1410             


Lys Glu  Asn Gly Asn Gly Pro  Met Thr Val Asp Lys  Asn Gly Ala 
    1415                 1420                 1425             


Val Leu  Ile Ala Asp Glu Ser  Asp Pro Ala Glu Ser  Met Glu Ser 
    1430                 1435                 1440             


Leu Val  
    1445 


<210>  396
<211>  1416
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15      


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30          


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45              


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60                  


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80  


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95      


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110         


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125             


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140                 


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160 


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175     


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190         


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205             


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220                 


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240 


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255     


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270         


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285             


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300                 


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320 


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335     


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350         


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365             


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380                 


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400 


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415     


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430         


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445             


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460                 


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480 


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495     


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510         


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525             


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540                 


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575     


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590         


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605             


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620                 


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640 


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655     


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670         


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685             


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700                 


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720 


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735     


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750         


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Lys Cys Phe Gln Thr 
        755                 760                 765             


Ala His Phe Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn 
    770                 775                 780                 


Glu Ser Ile Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro 
785                 790                 795                 800 


Val Lys Gln Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln 
                805                 810                 815     


His Gly Phe Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp 
            820                 825                 830         


Met Asn Ile Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys 
        835                 840                 845             


Asn Arg Tyr Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu 
    850                 855                 860                 


Arg Pro Leu Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala 
865                 870                 875                 880 


Asn Tyr Val Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln 
                885                 890                 895     


Gly Pro Leu Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu 
            900                 905                 910         


Gln Asn Thr Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly 
        915                 920                 925             


Arg Arg Lys Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr 
    930                 935                 940                 


Gly Asn Ile Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr 
945                 950                 955                 960 


Thr Val Arg Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln 
                965                 970                 975     


Lys Gly Asn Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr 
            980                 985                 990         


His Tyr Thr Gln Trp Pro Asp Met  Gly Val Pro Glu Tyr  Ala Leu Pro 
        995                 1000                 1005             


Val Leu  Thr Phe Val Arg Arg  Ser Ser Ala Ala Arg  Met Pro Glu 
    1010                 1015                 1020             


Thr Gly  Pro Val Leu Val His  Cys Ser Ala Gly Val  Gly Arg Thr 
    1025                 1030                 1035             


Gly Thr  Tyr Ile Val Ile Asp  Ser Met Leu Gln Gln  Ile Lys Asp 
    1040                 1045                 1050             


Lys Ser  Thr Val Asn Val Leu  Gly Phe Leu Lys His  Ile Arg Thr 
    1055                 1060                 1065             


Gln Arg  Asn Tyr Leu Val Gln  Thr Glu Glu Gln Tyr  Ile Phe Ile 
    1070                 1075                 1080             


His Asp  Ala Leu Leu Glu Ala  Ile Leu Gly Lys Glu  Thr Glu Val 
    1085                 1090                 1095             


Ser Ser  Asn Gln Leu His Ser  Tyr Val Asn Ser Ile  Leu Ile Pro 
    1100                 1105                 1110             


Gly Val  Gly Gly Lys Thr Arg  Leu Glu Lys Gln Phe  Lys Leu Val 
    1115                 1120                 1125             


Thr Gln  Cys Asn Ala Lys Tyr  Val Glu Cys Phe Ser  Ala Gln Lys 
    1130                 1135                 1140             


Glu Cys  Asn Lys Glu Lys Asn  Arg Asn Ser Ser Val  Val Pro Ser 
    1145                 1150                 1155             


Glu Arg  Ala Arg Val Gly Leu  Ala Pro Leu Pro Gly  Met Lys Gly 
    1160                 1165                 1170             


Thr Asp  Tyr Ile Asn Ala Ser  Tyr Ile Met Gly Tyr  Tyr Arg Ser 
    1175                 1180                 1185             


Asn Glu  Phe Ile Ile Thr Gln  His Pro Leu Pro His  Thr Thr Lys 
    1190                 1195                 1200             


Asp Phe  Trp Arg Met Ile Trp  Asp His Asn Ala Gln  Ile Ile Val 
    1205                 1210                 1215             


Met Leu  Pro Asp Asn Gln Ser  Leu Ala Glu Asp Glu  Phe Val Tyr 
    1220                 1225                 1230             


Trp Pro  Ser Arg Glu Glu Ser  Met Asn Cys Glu Ala  Phe Thr Val 
    1235                 1240                 1245             


Thr Leu  Ile Ser Lys Asp Arg  Leu Cys Leu Ser Asn  Glu Glu Gln 
    1250                 1255                 1260             


Ile Ile  Ile His Asp Phe Ile  Leu Glu Ala Thr Gln  Asp Asp Tyr 
    1265                 1270                 1275             


Val Leu  Glu Val Arg His Phe  Gln Cys Pro Lys Trp  Pro Asn Pro 
    1280                 1285                 1290             


Asp Ala  Pro Ile Ser Ser Thr  Phe Glu Leu Ile Asn  Val Ile Lys 
    1295                 1300                 1305             


Glu Glu  Ala Leu Thr Arg Asp  Gly Pro Thr Ile Val  His Asp Glu 
    1310                 1315                 1320             


Tyr Gly  Ala Val Ser Ala Gly  Met Leu Cys Ala Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Gln  Gln Leu Glu Asn Glu  Asn Ala Val Asp Val  Phe Gln Val 
    1340                 1345                 1350             


Ala Lys  Met Ile Asn Leu Met  Arg Pro Gly Val Phe  Thr Asp Ile 
    1355                 1360                 1365             


Glu Gln  Tyr Gln Phe Ile Tyr  Lys Ala Met Leu Ser  Leu Val Ser 
    1370                 1375                 1380             


Thr Lys  Glu Asn Gly Asn Gly  Pro Met Thr Val Asp  Lys Asn Gly 
    1385                 1390                 1395             


Ala Val  Leu Ile Ala Asp Glu  Ser Asp Pro Ala Glu  Ser Met Glu 
    1400                 1405                 1410             


Ser Leu  Val 
    1415     


<210>  397
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Lys Ile Ala Thr Val Ser Val Leu Leu Pro Leu Ala Leu Cys Leu 
1               5                   10                  15      


Ile Gln Asp Ala Ala Ser Lys Asn Glu Asp Gln Glu Met Cys His Glu 
            20                  25                  30          


Phe Gln Ala Phe Met Lys Asn Gly Lys Leu Phe Cys Pro Gln Asp Lys 
        35                  40                  45              


Lys Phe Phe Gln Ser Leu Asp Gly Ile Met Phe Ile Asn Lys Cys Ala 
    50                  55                  60                  


Thr Cys Lys Met Ile Leu Glu Lys Glu Ala Lys Ser Gln Lys Arg Ala 
65                  70                  75                  80  


Arg His Leu Ala Arg Ala Pro Lys Ala Thr Ala Pro Thr Glu Leu Asn 
                85                  90                  95      


Cys Asp Asp Phe Lys Lys Gly Glu Arg Asp Gly Asp Phe Ile Cys Pro 
            100                 105                 110         


Asp Tyr Tyr Glu Ala Val Cys Gly Thr Asp Gly Lys Thr Tyr Asp Asn 
        115                 120                 125             


Arg Cys Ala Leu Cys Ala Glu Asn Ala Lys Thr Gly Ser Gln Ile Gly 
    130                 135                 140                 


Val Lys Ser Glu Gly Glu Cys Lys Ser Ser Asn Pro Glu Gln Asp Val 
145                 150                 155                 160 


Cys Ser Ala Phe Arg Pro Phe Val Arg Asp Gly Arg Leu Gly Cys Thr 
                165                 170                 175     


Arg Glu Asn Asp Pro Val Leu Gly Pro Asp Gly Lys Thr His Gly Asn 
            180                 185                 190         


Lys Cys Ala Met Cys Ala Glu Leu Phe Leu Lys Glu Ala Glu Asn Ala 
        195                 200                 205             


Lys Arg Glu Gly Glu Thr Arg Ile Arg Arg Asn Ala Glu Lys Asp Phe 
    210                 215                 220                 


Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly Arg Leu Phe Cys Thr 
225                 230                 235                 240 


Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly Arg Met His Gly Asn 
                245                 250                 255     


Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Gln Arg Phe Ser Glu Glu 
            260                 265                 270         


Asn Ser Lys Thr Asp Gln Asn Leu Gly Lys Ala Glu Glu Lys Thr Lys 
        275                 280                 285             


Val Lys Arg Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala 
    290                 295                 300                 


Lys Asn Gly Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Arg Gly 
305                 310                 315                 320 


Pro Asp Gly Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr 
                325                 330                 335     


Phe Gln Ala Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Ala Arg 
            340                 345                 350         


Asn Lys Arg Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser 
        355                 360                 365             


Glu Tyr Arg Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu 
    370                 375                 380                 


Asn Asp Pro Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys 
385                 390                 395                 400 


Ser Met Cys Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys 
                405                 410                 415     


Lys Glu Gly Lys Ser Arg Asn Lys Arg Gln Ser Lys Ser Thr Ala Ser 
            420                 425                 430         


Phe Glu Glu Leu Cys Ser Glu Tyr Arg Lys Ser Arg Lys Asn Gly Arg 
        435                 440                 445             


Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Gln Gly Pro Asp Gly Lys 
    450                 455                 460                 


Met His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln Gln Glu 
465                 470                 475                 480 


Glu Arg Ala Arg Ala Lys Ala Lys Arg Glu Ala Ala Lys Glu Ile Cys 
                485                 490                 495     


Ser Glu Phe Arg Asp Gln Val Arg Asn Gly Thr Leu Ile Cys Thr Arg 
            500                 505                 510         


Glu His Asn Pro Val Arg Gly Pro Asp Gly Lys Met His Gly Asn Lys 
        515                 520                 525             


Cys Ala Met Cys Ala Ser Val Phe Lys Leu Glu Glu Glu Glu Lys Lys 
    530                 535                 540                 


Asn Asp Lys Glu Glu Lys Gly Lys Val Glu Ala Glu Lys Val Lys Arg 
545                 550                 555                 560 


Glu Ala Val Gln Glu Leu Cys Ser Glu Tyr Arg His Tyr Val Arg Asn 
                565                 570                 575     


Gly Arg Leu Pro Cys Thr Arg Glu Asn Asp Pro Ile Glu Gly Leu Asp 
            580                 585                 590         


Gly Lys Ile His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln 
        595                 600                 605             


Gln Glu Ala Lys Glu Lys Glu Arg Ala Glu Pro Arg Ala Lys Val Lys 
    610                 615                 620                 


Arg Glu Ala Glu Lys Glu Thr Cys Asp Glu Phe Arg Arg Leu Leu Gln 
625                 630                 635                 640 


Asn Gly Lys Leu Phe Cys Thr Arg Glu Asn Asp Pro Val Arg Gly Pro 
                645                 650                 655     


Asp Gly Lys Thr His Gly Asn Lys Cys Ala Met Cys Lys Ala Val Phe 
            660                 665                 670         


Gln Lys Glu Asn Glu Glu Arg Lys Arg Lys Glu Glu Glu Asp Gln Arg 
        675                 680                 685             


Asn Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln 
    690                 695                 700                 


Asp Glu Cys Ala Glu Tyr Arg Glu Gln Met Lys Asn Gly Arg Leu Ser 
705                 710                 715                 720 


Cys Thr Arg Glu Ser Asp Pro Val Arg Asp Ala Asp Gly Lys Ser Tyr 
                725                 730                 735     


Asn Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu 
            740                 745                 750         


Arg Lys Asn Glu Tyr Ser Arg Ser Arg Ser Asn Gly Thr Gly Ser Glu 
        755                 760                 765             


Ser Gly Lys Asp Thr Cys Asp Glu Phe Arg Ser Gln Met Lys Asn Gly 
    770                 775                 780                 


Lys Leu Ile Cys Thr Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly 
785                 790                 795                 800 


Lys Thr His Gly Asn Lys Cys Thr Met Cys Lys Glu Lys Leu Glu Arg 
                805                 810                 815     


Glu Ala Ala Glu Lys Lys Lys Lys Glu Asp Glu Asp Arg Ser Asn Thr 
            820                 825                 830         


Gly Glu Arg Ser Asn Thr Gly Glu Arg Ser Asn Asp Lys Glu Asp Leu 
        835                 840                 845             


Cys Arg Glu Phe Arg Ser Met Gln Arg Asn Gly Lys Leu Ile Cys Thr 
    850                 855                 860                 


Arg Glu Asn Asn Pro Val Arg Gly Pro Tyr Gly Lys Met His Ile Asn 
865                 870                 875                 880 


Lys Cys Ala Met Cys Gln Ser Ile Phe Asp Arg Glu Ala Asn Glu Arg 
                885                 890                 895     


Lys Lys Lys Asp Glu Glu Lys Ser Ser Ser Lys Pro Ser Asn Asn Ala 
            900                 905                 910         


Lys Asp Glu Cys Ser Glu Phe Arg Asn Tyr Ile Arg Asn Asn Glu Leu 
        915                 920                 925             


Ile Cys Pro Arg Glu Asn Asp Pro Val His Gly Ala Asp Gly Lys Phe 
    930                 935                 940                 


Tyr Thr Asn Lys Cys Tyr Met Cys Arg Ala Val Phe Leu Thr Glu Ala 
945                 950                 955                 960 


Leu Glu Arg Ala Lys Leu Gln Glu Lys Pro Ser His Val Arg Ala Ser 
                965                 970                 975     


Gln Glu Glu Asp Ser Pro Asp Ser Phe Ser Ser Leu Asp Ser Glu Met 
            980                 985                 990         


Cys Lys Asp Tyr Arg Val Leu Pro  Arg Ile Gly Tyr Leu  Cys Pro Lys 
        995                 1000                 1005             


Asp Leu  Lys Pro Val Cys Gly  Asp Asp Gly Gln Thr  Tyr Asn Asn 
    1010                 1015                 1020             


Pro Cys  Met Leu Cys His Glu  Asn Leu Ile Arg Gln  Thr Asn Thr 
    1025                 1030                 1035             


His Ile  Arg Ser Thr Gly Lys  Cys Glu Glu Ser Ser  Thr Pro Gly 
    1040                 1045                 1050             


Thr Thr  Ala Ala Ser Met Pro  Pro Ser Asp Glu 
    1055                 1060                 


<210>  398
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Lys Ile Ala Thr Val Ser Val Leu Leu Pro Leu Ala Leu Cys Leu 
1               5                   10                  15      


Ile Gln Asp Ala Ala Ser Lys Asn Glu Asp Gln Glu Met Cys His Glu 
            20                  25                  30          


Phe Gln Ala Phe Met Lys Asn Gly Lys Leu Phe Cys Pro Gln Asp Lys 
        35                  40                  45              


Lys Phe Phe Gln Ser Leu Asp Gly Ile Met Phe Ile Asn Lys Cys Ala 
    50                  55                  60                  


Thr Cys Lys Met Ile Leu Glu Lys Glu Ala Lys Ser Gln Lys Arg Ala 
65                  70                  75                  80  


Arg His Leu Ala Arg Ala Pro Lys Ala Thr Ala Pro Thr Glu Leu Asn 
                85                  90                  95      


Cys Asp Asp Phe Lys Lys Gly Glu Arg Asp Gly Asp Phe Ile Cys Pro 
            100                 105                 110         


Asp Tyr Tyr Glu Ala Val Cys Gly Thr Asp Gly Lys Thr Tyr Asp Asn 
        115                 120                 125             


Arg Cys Ala Leu Cys Ala Glu Asn Ala Lys Thr Gly Ser Gln Ile Gly 
    130                 135                 140                 


Val Lys Ser Glu Gly Glu Cys Lys Ser Ser Asn Pro Glu Gln Asp Val 
145                 150                 155                 160 


Cys Ser Ala Phe Arg Pro Phe Val Arg Asp Gly Arg Leu Gly Cys Thr 
                165                 170                 175     


Arg Glu Asn Asp Pro Val Leu Gly Pro Asp Gly Lys Thr His Gly Asn 
            180                 185                 190         


Lys Cys Ala Met Cys Ala Glu Leu Phe Leu Lys Glu Ala Glu Asn Ala 
        195                 200                 205             


Lys Arg Glu Gly Glu Thr Arg Ile Arg Arg Asn Ala Glu Lys Asp Phe 
    210                 215                 220                 


Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly Arg Leu Phe Cys Thr 
225                 230                 235                 240 


Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly Arg Met His Gly Asn 
                245                 250                 255     


Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Gln Arg Phe Ser Glu Glu 
            260                 265                 270         


Asn Ser Lys Thr Asp Gln Asn Leu Gly Lys Ala Glu Glu Lys Thr Lys 
        275                 280                 285             


Val Lys Arg Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala 
    290                 295                 300                 


Lys Asn Gly Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Arg Gly 
305                 310                 315                 320 


Pro Asp Gly Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr 
                325                 330                 335     


Phe Gln Ala Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Ala Arg 
            340                 345                 350         


Asn Lys Arg Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser 
        355                 360                 365             


Glu Tyr Arg Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu 
    370                 375                 380                 


Asn Asp Pro Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys 
385                 390                 395                 400 


Ser Met Cys Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys 
                405                 410                 415     


Lys Glu Gly Lys Ser Arg Asn Lys Arg Gln Ser Lys Ser Thr Ala Ser 
            420                 425                 430         


Phe Glu Glu Leu Cys Ser Glu Tyr Arg Lys Ser Arg Lys Asn Gly Arg 
        435                 440                 445             


Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Gln Gly Pro Asp Gly Lys 
    450                 455                 460                 


Met His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln Gln Glu 
465                 470                 475                 480 


Glu Arg Ala Arg Ala Lys Ala Lys Arg Glu Ala Ala Lys Glu Ile Cys 
                485                 490                 495     


Ser Glu Phe Arg Asp Gln Val Arg Asn Gly Thr Leu Ile Cys Thr Arg 
            500                 505                 510         


Glu His Asn Pro Val Arg Gly Pro Asp Gly Lys Met His Gly Asn Lys 
        515                 520                 525             


Cys Ala Met Cys Ala Ser Val Phe Lys Leu Glu Glu Glu Glu Lys Lys 
    530                 535                 540                 


Asn Asp Lys Glu Glu Lys Gly Lys Val Glu Ala Glu Lys Val Lys Arg 
545                 550                 555                 560 


Glu Ala Val Gln Glu Leu Cys Ser Glu Tyr Arg His Tyr Val Arg Asn 
                565                 570                 575     


Gly Arg Leu Pro Cys Thr Arg Glu Asn Asp Pro Ile Glu Gly Leu Asp 
            580                 585                 590         


Gly Lys Ile His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln 
        595                 600                 605             


Gln Glu Ala Lys Glu Lys Glu Arg Ala Glu Pro Arg Ala Lys Val Lys 
    610                 615                 620                 


Arg Glu Ala Glu Lys Glu Thr Cys Asp Glu Phe Arg Arg Leu Leu Gln 
625                 630                 635                 640 


Asn Gly Lys Leu Phe Cys Thr Arg Glu Asn Asp Pro Val Arg Gly Pro 
                645                 650                 655     


Asp Gly Lys Thr His Gly Asn Lys Cys Ala Met Cys Lys Ala Val Phe 
            660                 665                 670         


Gln Lys Glu Asn Glu Glu Arg Lys Arg Lys Glu Glu Glu Asp Gln Arg 
        675                 680                 685             


Asn Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln 
    690                 695                 700                 


Asp Glu Cys Ala Glu Tyr Arg Glu Gln Met Lys Asn Gly Arg Leu Ser 
705                 710                 715                 720 


Cys Thr Arg Glu Ser Asp Pro Val Arg Asp Ala Asp Gly Lys Ser Tyr 
                725                 730                 735     


Asn Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu 
            740                 745                 750         


Arg Lys Asn Glu Tyr Ser Arg Ser Arg Ser Asn Gly Thr Gly Ser Glu 
        755                 760                 765             


Ser Gly Lys Asp Thr Cys Asp Glu Phe Arg Ser Gln Met Lys Asn Gly 
    770                 775                 780                 


Lys Leu Ile Cys Thr Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly 
785                 790                 795                 800 


Lys Thr His Gly Asn Lys Cys Thr Met Cys Lys Glu Lys Leu Glu Arg 
                805                 810                 815     


Glu Ala Ala Glu Lys Lys Lys Lys Glu Asp Glu Asp Arg Ser Asn Thr 
            820                 825                 830         


Gly Glu Arg Ser Asn Thr Gly Glu Arg Ser Asn Asp Lys Glu Asp Leu 
        835                 840                 845             


Cys Arg Glu Phe Arg Ser Met Gln Arg Asn Gly Lys Leu Ile Cys Thr 
    850                 855                 860                 


Arg Glu Asn Asn Pro Val Arg Gly Pro Tyr Gly Lys Met His Ile Asn 
865                 870                 875                 880 


Lys Cys Ala Met Cys Gln Ser Ile Phe Asp Arg Glu Ala Asn Glu Arg 
                885                 890                 895     


Lys Lys Lys Asp Glu Glu Lys Ser Ser Ser Lys Pro Ser Asn Asn Ala 
            900                 905                 910         


Lys Val Ile Tyr 
        915     


<210>  399
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Lys Ile Ala Thr Val Ser Val Leu Leu Pro Leu Ala Leu Cys Leu 
1               5                   10                  15      


Ile Gln Asp Ala Ala Ser Lys Asn Glu Asp Gln Glu Met Cys His Glu 
            20                  25                  30          


Phe Gln Ala Phe Met Lys Asn Gly Lys Leu Phe Cys Pro Gln Asp Lys 
        35                  40                  45              


Lys Phe Phe Gln Ser Leu Asp Gly Ile Met Phe Ile Asn Lys Cys Ala 
    50                  55                  60                  


Thr Cys Lys Met Ile Leu Glu Lys Glu Ala Lys Ser Gln Lys Arg Ala 
65                  70                  75                  80  


Arg His Leu Ala Arg Ala Pro Lys Ala Thr Ala Pro Thr Glu Leu Asn 
                85                  90                  95      


Cys Asp Asp Phe Lys Lys Gly Glu Arg Asp Gly Asp Phe Ile Cys Pro 
            100                 105                 110         


Asp Tyr Tyr Glu Ala Val Cys Gly Thr Asp Gly Lys Thr Tyr Asp Asn 
        115                 120                 125             


Arg Cys Ala Leu Cys Ala Glu Asn Ala Lys Thr Gly Ser Gln Ile Gly 
    130                 135                 140                 


Val Lys Ser Glu Gly Glu Cys Lys Ser Ser Asn Pro Glu Gln Asp Val 
145                 150                 155                 160 


Cys Ser Ala Phe Arg Pro Phe Val Arg Asp Gly Arg Leu Gly Cys Thr 
                165                 170                 175     


Arg Glu Asn Asp Pro Val Leu Gly Pro Asp Gly Lys Thr His Gly Asn 
            180                 185                 190         


Lys Cys Ala Met Cys Ala Glu Leu Phe Leu Lys Glu Ala Glu Asn Ala 
        195                 200                 205             


Lys Arg Glu Gly Glu Thr Arg Ile Arg Arg Asn Ala Glu Lys Asp Phe 
    210                 215                 220                 


Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly Arg Leu Phe Cys Thr 
225                 230                 235                 240 


Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly Arg Met His Gly Asn 
                245                 250                 255     


Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Gln Arg Phe Ser Glu Glu 
            260                 265                 270         


Asn Ser Lys Thr Asp Gln Asn Leu Gly Lys Ala Glu Glu Lys Thr Lys 
        275                 280                 285             


Val Lys Arg Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala 
    290                 295                 300                 


Lys Asn Gly Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Arg Gly 
305                 310                 315                 320 


Pro Asp Gly Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr 
                325                 330                 335     


Phe Gln Ala Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Ala Arg 
            340                 345                 350         


Asn Lys Arg Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser 
        355                 360                 365             


Glu Tyr Arg Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu 
    370                 375                 380                 


Asn Asp Pro Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys 
385                 390                 395                 400 


Ser Met Cys Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys 
                405                 410                 415     


Lys Glu Gly Lys Ser Arg Asn Lys Arg Gln Ser Lys Ser Thr Ala Ser 
            420                 425                 430         


Phe Glu Glu Leu Cys Ser Glu Tyr Arg Lys Ser Arg Lys Asn Gly Arg 
        435                 440                 445             


Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Gln Gly Pro Asp Gly Lys 
    450                 455                 460                 


Met His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln Gln Glu 
465                 470                 475                 480 


Glu Arg Ala Arg Ala Lys Ala Lys Arg Glu Ala Ala Lys Glu Ile Cys 
                485                 490                 495     


Ser Glu Phe Arg Asp Gln Val Arg Asn Gly Thr Leu Ile Cys Thr Arg 
            500                 505                 510         


Glu His Asn Pro Val Arg Gly Pro Asp Gly Lys Met His Gly Asn Lys 
        515                 520                 525             


Cys Ala Met Cys Ala Ser Val Phe Lys Leu Glu Glu Glu Glu Lys Lys 
    530                 535                 540                 


Asn Asp Lys Glu Glu Lys Gly Lys Val Glu Ala Glu Lys Val Lys Arg 
545                 550                 555                 560 


Glu Ala Val Gln Glu Leu Cys Ser Glu Tyr Arg His Tyr Val Arg Asn 
                565                 570                 575     


Gly Arg Leu Pro Cys Thr Arg Glu Asn Asp Pro Ile Glu Gly Leu Asp 
            580                 585                 590         


Gly Lys Ile His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln 
        595                 600                 605             


Gln Glu Ala Lys Glu Lys Glu Arg Ala Glu Pro Arg Ala Lys Val Lys 
    610                 615                 620                 


Arg Glu Ala Glu Lys Glu Thr Cys Asp Glu Phe Arg Arg Leu Leu Gln 
625                 630                 635                 640 


Asn Gly Lys Leu Phe Cys Thr Arg Glu Asn Asp Pro Val Arg Gly Pro 
                645                 650                 655     


Asp Gly Lys Thr His Gly Asn Lys Cys Ala Met Cys Lys Ala Val Phe 
            660                 665                 670         


Gln Lys Glu Asn Glu Glu Arg Lys Arg Lys Glu Glu Glu Asp Gln Arg 
        675                 680                 685             


Asn Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln 
    690                 695                 700                 


Asp Glu Cys Ala Glu Tyr Arg Glu Gln Met Lys Asn Gly Arg Leu Ser 
705                 710                 715                 720 


Cys Thr Arg Glu Ser Asp Pro Val Arg Asp Ala Asp Gly Lys Ser Tyr 
                725                 730                 735     


Asn Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu 
            740                 745                 750         


Arg Lys Asn Glu Tyr Ser Arg Ser Arg Ser Asn Gly Thr Gly Ser Glu 
        755                 760                 765             


Ser Gly Lys Asp Thr Cys Asp Glu Phe Arg Ser Gln Met Lys Asn Gly 
    770                 775                 780                 


Lys Leu Ile Cys Thr Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly 
785                 790                 795                 800 


Lys Thr His Gly Asn Lys Cys Thr Met Cys Lys Glu Lys Leu Glu Arg 
                805                 810                 815     


Glu Ala Ala Glu Lys Lys Lys Lys Glu Asp Glu Asp Arg Ser Asn Thr 
            820                 825                 830         


Gly Glu Arg Ser Asn Thr Gly Glu Arg Ser Asn Asp Lys Glu Asp Leu 
        835                 840                 845             


Cys Arg Glu Phe Arg Ser Met Gln Arg Asn Gly Lys Leu Ile Cys Thr 
    850                 855                 860                 


Arg Glu Asn Asn Pro Val Arg Gly Pro Tyr Gly Lys Met His Ile Asn 
865                 870                 875                 880 


Lys Cys Ala Met Cys Gln Ser Ile Phe Asp Arg Glu Ala Asn Glu Arg 
                885                 890                 895     


Lys Lys Lys Asp Glu Glu Lys Ser Ser Ser Lys Pro Ser Asn Asn Ala 
            900                 905                 910         


Lys Asp Gln Cys Arg Gln Val Gln Asn Glu Ala Glu Asp Ala Lys Phe 
        915                 920                 925             


Arg Gln Pro Gly Arg Ser Leu Ala Ser Val Ala Arg Met Ser Thr Asp 
    930                 935                 940                 


Glu Cys Ser Glu Phe Arg Asn Tyr Ile Arg Asn Asn Glu Leu Ile Cys 
945                 950                 955                 960 


Pro Arg Glu Asn Asp Pro Val His Gly Ala Asp Gly Lys Phe Tyr Thr 
                965                 970                 975     


Asn Lys Cys Tyr Met Cys Arg Ala Val Phe Leu Thr Glu Ala Leu Glu 
            980                 985                 990         


Arg Ala Lys Leu Gln Glu Lys Pro  Ser His Val Arg Ala  Ser Gln Glu 
        995                 1000                 1005             


Glu Asp  Ser Pro Asp Ser Phe  Ser Ser Leu Asp Ser  Glu Met Cys 
    1010                 1015                 1020             


Lys Asp  Tyr Arg Val Leu Pro  Arg Ile Gly Tyr Leu  Cys Pro Lys 
    1025                 1030                 1035             


Asp Leu  Lys Pro Val Cys Gly  Asp Asp Gly Gln Thr  Tyr Asn Asn 
    1040                 1045                 1050             


Pro Cys  Met Leu Cys His Glu  Asn Leu Ile Arg Gln  Thr Asn Thr 
    1055                 1060                 1065             


His Ile  Arg Ser Thr Gly Lys  Cys Glu Glu Ser Ser  Thr Pro Gly 
    1070                 1075                 1080             


Thr Thr  Ala Ala Ser Met Pro  Pro Ser Asp Glu 
    1085                 1090                 


<210>  400
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Lys Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Gly Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Leu Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Val Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Ile Pro Glu Gly Asn Ile Gly Ser Asn Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Lys Lys Phe Asn Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Asn Thr Tyr Lys 
        195                 200                 205             


Ser Ile Gln Met Met Arg Gln Tyr Thr Ser Phe His Phe Ala Ser Leu 
    210                 215                 220                 


Glu Asp Val Gln Ala Lys Val Leu Glu Ile Pro Tyr Lys Gly Lys Asp 
225                 230                 235                 240 


Leu Ser Met Ile Val Leu Leu Pro Asn Glu Ile Asp Gly Leu Gln Lys 
                245                 250                 255     


Leu Glu Glu Lys Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu 
            260                 265                 270         


Gln Asn Met Arg Glu Thr Arg Val Asp Leu His Leu Pro Arg Phe Lys 
        275                 280                 285             


Val Glu Glu Ser Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met 
    290                 295                 300                 


Val Asp Ile Phe Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Gly Ser 
305                 310                 315                 320 


Arg Gly Leu Val Leu Ser Gly Val Leu His Lys Ala Phe Val Glu Val 
                325                 330                 335     


Thr Glu Glu Gly Ala Glu Ala Ala Ala Ala Thr Ala Val Val Gly Phe 
            340                 345                 350         


Gly Ser Ser Pro Thr Ser Thr Asn Glu Glu Phe His Cys Asn His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210>  401
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Lys Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Gly Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Leu Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Val Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Ile Pro Glu Gly Asn Ile Gly Ser Asn Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Lys Lys Phe Asn Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Leu Glu Glu Lys 
        195                 200                 205             


Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu Gln Asn Met Arg 
    210                 215                 220                 


Glu Thr Arg Val Asp Leu His Leu Pro Arg Phe Lys Val Glu Glu Ser 
225                 230                 235                 240 


Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met Val Asp Ile Phe 
                245                 250                 255     


Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Gly Ser Arg Gly Leu Val 
            260                 265                 270         


Leu Ser Gly Val Leu His Lys Ala Phe Val Glu Val Thr Glu Glu Gly 
        275                 280                 285             


Ala Glu Ala Ala Ala Ala Thr Ala Val Val Gly Phe Gly Ser Ser Pro 
    290                 295                 300                 


Thr Ser Thr Asn Glu Glu Phe His Cys Asn His Pro Phe Leu Phe Phe 
305                 310                 315                 320 


Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr Gly Arg Phe Ser 
                325                 330                 335     


Ser Pro 
        


<210>  402
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Lys Leu Ala Val Thr Leu Thr Leu Val Thr Leu Ala Leu Cys Cys 
1               5                   10                  15      


Ser Ser Ala Ser Ala Glu Ile Cys Pro Ser Phe Gln Arg Val Ile Glu 
            20                  25                  30          


Thr Leu Leu Met Asp Thr Pro Ser Ser Tyr Glu Ala Ala Met Glu Leu 
        35                  40                  45              


Phe Ser Pro Asp Gln Asp Met Arg Glu Ala Gly Ala Gln Leu Lys Lys 
    50                  55                  60                  


Leu Val Asp Thr Leu Pro Gln Lys Pro Arg Glu Ser Ile Ile Lys Leu 
65                  70                  75                  80  


Met Glu Lys Ile Ala Gln Ser Ser Leu Cys Asn 
                85                  90      


<210>  403
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro 
1               5                   10                  15      


Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu 
            20                  25                  30          


Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu 
        35                  40                  45              


Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln 
    50                  55                  60                  


Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr 
65                  70                  75                  80  


Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg 
                85                  90                  95      


Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn 
            100                 105                 110         


Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val 
        115                 120                 125             


Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala 
    130                 135                 140                 


Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly 
145                 150                 155                 160 


Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu 
                165                 170                 175     


Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala 
            180                 185                 190         


Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln 
        195                 200                 205             


Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu 
    210                 215                 220                 


Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr 
225                 230                 235                 240 


Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val 
                245                 250                 255     


Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser 
            260                 265                 270         


Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys 
        275                 280                 285             


Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly 
    290                 295                 300                 


Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly 
                325                 330                 335     


Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val 
            340                 345                 350         


Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro 
        355                 360                 365             


Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala 
    370                 375                 380                 


Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp 
385                 390                 395                 400 


Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val 
                405                 410                 


<210>  404
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Gly Met Leu Ala Pro Gly Pro Leu Gln Gly Arg Arg Pro Arg Lys 
1               5                   10                  15      


Gly His Lys Gly Gln Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser 
            20                  25                  30          


Gly Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn 
        35                  40                  45              


Val Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly 
    50                  55                  60                  


Pro Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu 
65                  70                  75                  80  


Ala Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala 
                85                  90                  95      


Asp Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val Ser 
            100                 105                 110         


Ser Pro His Cys Glu Glu Pro Cys Ala His Ser Cys Ala His Pro Gly 
        115                 120                 125             


Leu Pro Pro His Leu Val His Lys Leu Pro Leu Ser Tyr Leu Gln Thr 
    130                 135                 140                 


Gln Asp Thr Asp Ala Ala Ser Arg Arg Ile Asn Ala Pro Leu Ala Ala 
145                 150                 155                 160 


Gly Trp Ser Trp Leu Arg Leu Trp Leu Val Thr Leu Ala Ser Gly Val 
                165                 170                 175     


Asp Phe Pro Gln Val Ser Ala Trp Met Arg Ala Leu Pro Ser Pro Asp 
            180                 185                 190         


Cys Pro Gly Leu Arg Thr Thr Gly Glu Gln Met Gln Lys Leu Leu Leu 
        195                 200                 205             


Lys Glu Asn Lys Val Lys Thr Arg Lys Ser Lys Arg Arg Ser Gly Glu 
    210                 215                 220                 


Gly Ser His Leu Thr Thr Ser Ile Leu Glu Gln 
225                 230                 235 


