                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
       Grandori, Carla
       Toyoshima, Masafumi
 
<120>  Methods for Identifying and Using Inhibitors of Casein Kinase 1 
       Epsilon Isoform for Inhibiting the Growth and/or Proliferation of
        Myc-Driven Tumor Cells

<130>  FHCR-1-36613

<150>  US 61/321,414
<151>  2010-04-06

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1251
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1251)

<400>  1
atg gag cta cgt gtg ggg aac aag tac cgc ctg gga cgg aag atc ggg         48
Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly           
1               5                   10                  15                

agc ggg tcc ttc gga gat atc tac ctg ggt gcc aac atc gcc tct ggt         96
Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly           
            20                  25                  30                    

gag gaa gtc gcc atc aag ctg gag tgt gtg aag aca aag cac ccc cag        144
Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln           
        35                  40                  45                        

ctg cac atc gag agc aag ttc tac aag atg atg cag ggt ggc gtg ggg        192
Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly           
    50                  55                  60                            

atc ccg tcc atc aag tgg tgc gga gct gag ggc gac tac aac gtg atg        240
Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met           
65                  70                  75                  80            

gtc atg gag ctg ctg ggg cct agc ctc gag gac ctg ttc aac ttc tgt        288
Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys           
                85                  90                  95                

tcc cgc aaa ttc agc ctc aag acg gtg ctg ctc ttg gcc gac cag atg        336
Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met           
            100                 105                 110                   

atc agc cgc atc gag tat atc cac tcc aag aac ttc atc cac cgg gac        384
Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp           
        115                 120                 125                       

gtc aag ccc gac aac ttc ctc atg ggg ctg ggg aag aag ggc aac ctg        432
Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu           
    130                 135                 140                           

gtc tac atc atc gac ttc ggc ctg gcc aag aag tac cgg gac gcc cgc        480
Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg           
145                 150                 155                 160           

acc cac cag cac att ccc tac cgg gaa aac aag aac ctg acc ggc acg        528
Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr           
                165                 170                 175               

gcc cgc tac gct tcc atc aac acg cac ctg ggc att gag caa agc cgt        576
Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg           
            180                 185                 190                   

cga gat gac ctg gag agc ctg ggc tac gtg ctc atg tac ttc aac ctg        624
Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu           
        195                 200                 205                       

ggc tcc ctg ccc tgg cag ggg ctc aaa gca gcc acc aag cgc cag aag        672
Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys           
    210                 215                 220                           

tat gaa cgg atc agc gag aag aag atg tca acg ccc atc gag gtc ctc        720
Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu           
225                 230                 235                 240           

tgc aaa ggc tat ccc tcc gaa ttc tca aca tac ctc aac ttc tgc cgc        768
Cys Lys Gly Tyr Pro Ser Glu Phe Ser Thr Tyr Leu Asn Phe Cys Arg           
                245                 250                 255               

tcc ctg cgg ttt gac gac aag ccc gac tac tct tac cta cgt cag ctc        816
Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu           
            260                 265                 270                   

ttc cgc aac ctc ttc cac cgg cag ggc ttc tcc tat gac tac gtc ttt        864
Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe           
        275                 280                 285                       

gac tgg aac atg ctg aaa ttc ggt gca gcc cgg aat ccc gag gat gtg        912
Asp Trp Asn Met Leu Lys Phe Gly Ala Ala Arg Asn Pro Glu Asp Val           
    290                 295                 300                           

gac cgg gag cgg cga gaa cac gaa cgc gag gag agg atg ggg cag cta        960
Asp Arg Glu Arg Arg Glu His Glu Arg Glu Glu Arg Met Gly Gln Leu           
305                 310                 315                 320           

cgg ggg tcc gcg acc cga gcc ctg ccc cct ggc cca ccc acg ggg gcc       1008
Arg Gly Ser Ala Thr Arg Ala Leu Pro Pro Gly Pro Pro Thr Gly Ala           
                325                 330                 335               

act gcc aac cgg ctc cgc agt gcc gcc gag ccc gtg gct tcc acg cca       1056
Thr Ala Asn Arg Leu Arg Ser Ala Ala Glu Pro Val Ala Ser Thr Pro           
            340                 345                 350                   

gcc tcc cgc atc cag ccg gct ggc aat act tct ccc aga gcg atc tcg       1104
Ala Ser Arg Ile Gln Pro Ala Gly Asn Thr Ser Pro Arg Ala Ile Ser           
        355                 360                 365                       

cgg gtc gac cgg gag agg aag gtg agt atg agg ctg cac agg ggt gcg       1152
Arg Val Asp Arg Glu Arg Lys Val Ser Met Arg Leu His Arg Gly Ala           
    370                 375                 380                           

ccc gcc aac gtc tcc tcc tca gac ctc act ggg cgg caa gag gtc tcc       1200
Pro Ala Asn Val Ser Ser Ser Asp Leu Thr Gly Arg Gln Glu Val Ser           
385                 390                 395                 400           

cgg atc cca gcc tca cag aca agt gtg cca ttt gac cat ctc ggg aag       1248
Arg Ile Pro Ala Ser Gln Thr Ser Val Pro Phe Asp His Leu Gly Lys           
                405                 410                 415               

tga                                                                   1251


<210>  2
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ser Thr Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ala Arg Asn Pro Glu Asp Val 
    290                 295                 300                 


Asp Arg Glu Arg Arg Glu His Glu Arg Glu Glu Arg Met Gly Gln Leu 
305                 310                 315                 320 


Arg Gly Ser Ala Thr Arg Ala Leu Pro Pro Gly Pro Pro Thr Gly Ala 
                325                 330                 335     


Thr Ala Asn Arg Leu Arg Ser Ala Ala Glu Pro Val Ala Ser Thr Pro 
            340                 345                 350         


Ala Ser Arg Ile Gln Pro Ala Gly Asn Thr Ser Pro Arg Ala Ile Ser 
        355                 360                 365             


Arg Val Asp Arg Glu Arg Lys Val Ser Met Arg Leu His Arg Gly Ala 
    370                 375                 380                 


Pro Ala Asn Val Ser Ser Ser Asp Leu Thr Gly Arg Gln Glu Val Ser 
385                 390                 395                 400 


Arg Ile Pro Ala Ser Gln Thr Ser Val Pro Phe Asp His Leu Gly Lys 
                405                 410                 415     


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggctatccct ccgaattct                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
gaacggatca gcgagaaga                                                    19


