                         SEQUENCE LISTING

<110>  Tocagen Inc.
       Gruber, Harry E.
       Jolly, Douglas
       Perez, Omar
       Ostertag, Derek G.
       Robbins, Joan M.
 
<120>  CANCER TREATMENT WITH RECOMBINANT VECTOR

<130>  00014-009WO1

<140>  Not yet known
<141>  2011-03-29

<150>  US 61/318,728
<151>  2010-03-29

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  477
<212>  DNA
<213>  Saccharomyces cerevisiae


<220>
<221>  CDS
<222>  (1)..(477)

<400>  1
atg gtg aca ggg gga atg gca agc aag tgg gat cag aag ggt atg gac         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

att gcc tat gag gag gcg gcc tta ggt tac aaa gag ggt ggt gtt cct         96
Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

att ggc gga tgt ctt atc aat aac aaa gac gga agt gtt ctc ggt cgt        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggt cac aac atg aga ttt caa aag gga tcc gcc aca cta cat ggt gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc act ttg gaa aac tgt ggg aga tta gag ggc aaa gtg tac aaa        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gat acc act ttg tat acg acg ctg tct cca tgc gac atg tgt aca ggt        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gcc atc atc atg tat ggt att cca cgc tgt gtt gtc ggt gag aac gtt        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val           
            100                 105                 110                   

aat ttc aaa agt aag ggc gag aaa tat tta caa act aga ggt cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtt gtt gtt gtt gac gat gag agg tgt aaa aag atc atg aaa caa ttt        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe           
    130                 135                 140                           

atc gat gaa aga cct cag gat tgg ttt gaa gat att ggt gag tag            477
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu                   
145                 150                 155                               


<210>  2
<211>  158
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  3
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered cytosine deaminase


<220>
<221>  CDS
<222>  (1)..(477)

<400>  3
atg gtg aca ggg gga atg gca agc aag tgg gat cag aag ggt atg gac         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

att gcc tat gag gag gcg tta tta ggt tac aaa gag ggt ggt gtt cct         96
Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

att ggc gga tgt ctt atc aat aac aaa gac gga agt gtt ctc ggt cgt        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggt cac aac atg aga ttt caa aag gga tcc gcc aca cta cat ggt gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc act ttg gaa aac tgt ggg aga tta gag ggc aaa gtg tac aaa        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gat acc act ttg tat acg acg ctg tct cca tgc gac atg tgt aca ggt        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gcc atc atc atg tat ggt att cca cgc tgt gtc atc ggt gag aac gtt        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val           
            100                 105                 110                   

aat ttc aaa agt aag ggc gag aaa tat tta caa act aga ggt cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtt gtt gtt gtt gac gat gag agg tgt aaa aag tta atg aaa caa ttt        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe           
    130                 135                 140                           

atc gat gaa aga cct cag gat tgg ttt gaa gat att ggt gag tag            477
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu                   
145                 150                 155                               


<210>  4
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human codon optimized cytosine deaminase


<220>
<221>  CDS
<222>  (1)..(480)

<400>  5
atg gtg acc ggc ggc atg gcc tcc aag tgg gat caa aag ggc atg gat         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

atc gct tac gag gag gcc gca ctg ggc tac aag gag ggc ggc gtg cct         96
Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

atc ggc ggc tgt ctg atc aac aac aag gac ggc agt gtg ctg ggc agg        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggc cac aac atg agg ttc cag aag ggc tcc gcc acc ctg cac ggc gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc acc ctg gag aac tgt ggc agg ctg gag ggc aag gtg tac aag        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gac acc acc ctg tac acc acc ctg tcc cct tgt gac atg tgt acc ggc        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gct atc atc atg tac ggc atc cct agg tgt gtg gtc ggc gag aac gtg        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val           
            100                 105                 110                   

aac ttc aag tcc aag ggc gag aag tac ctg caa acc agg ggc cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtg gtg gtt gtt gac gat gag agg tgt aag aag atc atg aag cag ttc        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe           
    130                 135                 140                           

atc gac gag agg cct cag gac tgg ttc gag gat atc ggc gag tga taa        480
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu                   
145                 150                 155                               


<210>  6
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  7
<211>  756
<212>  DNA
<213>  Saccharomyces cerevisiae


<220>
<221>  CDS
<222>  (1)..(756)

<400>  7
atg aac ccg tta ttc ttt ttg gct tct cca ttc ttg tac ctt aca tat         48
Met Asn Pro Leu Phe Phe Leu Ala Ser Pro Phe Leu Tyr Leu Thr Tyr           
1               5                   10                  15                

ctt ata tat tat cca aac aaa ggg tct ttc gtt agc aaa cct aga aat         96
Leu Ile Tyr Tyr Pro Asn Lys Gly Ser Phe Val Ser Lys Pro Arg Asn           
            20                  25                  30                    

ctg caa aaa atg tct tcg gaa cca ttt aag aac gtc tac ttg cta cct        144
Leu Gln Lys Met Ser Ser Glu Pro Phe Lys Asn Val Tyr Leu Leu Pro           
        35                  40                  45                        

caa aca aac caa ttg ctg ggt ttg tac acc atc atc aga aat aag aat        192
Gln Thr Asn Gln Leu Leu Gly Leu Tyr Thr Ile Ile Arg Asn Lys Asn           
    50                  55                  60                            

aca act aga cct gat ttc att ttc tac tcc gat aga atc atc aga ttg        240
Thr Thr Arg Pro Asp Phe Ile Phe Tyr Ser Asp Arg Ile Ile Arg Leu           
65                  70                  75                  80            

ttg gtt gaa gaa ggt ttg aac cat cta cct gtg caa aag caa att gtg        288
Leu Val Glu Glu Gly Leu Asn His Leu Pro Val Gln Lys Gln Ile Val           
                85                  90                  95                

gaa act gac acc aac gaa aac ttc gaa ggt gtc tca ttc atg ggt aaa        336
Glu Thr Asp Thr Asn Glu Asn Phe Glu Gly Val Ser Phe Met Gly Lys           
            100                 105                 110                   

atc tgt ggt gtt tcc att gtc aga gct ggt gaa tcg atg gag caa gga        384
Ile Cys Gly Val Ser Ile Val Arg Ala Gly Glu Ser Met Glu Gln Gly           
        115                 120                 125                       

tta aga gac tgt tgt agg tct gtg cgt atc ggt aaa att tta att caa        432
Leu Arg Asp Cys Cys Arg Ser Val Arg Ile Gly Lys Ile Leu Ile Gln           
    130                 135                 140                           

agg gac gag gag act gct tta cca aag tta ttc tac gaa aaa tta cca        480
Arg Asp Glu Glu Thr Ala Leu Pro Lys Leu Phe Tyr Glu Lys Leu Pro           
145                 150                 155                 160           

gag gat ata tct gaa agg tat gtc ttc cta tta gac cca atg ctg gcc        528
Glu Asp Ile Ser Glu Arg Tyr Val Phe Leu Leu Asp Pro Met Leu Ala           
                165                 170                 175               

acc ggt ggt agt gct atc atg gct aca gaa gtc ttg att aag aga ggt        576
Thr Gly Gly Ser Ala Ile Met Ala Thr Glu Val Leu Ile Lys Arg Gly           
            180                 185                 190                   

gtt aag cca gag aga att tac ttc tta aac cta atc tgt agt aag gaa        624
Val Lys Pro Glu Arg Ile Tyr Phe Leu Asn Leu Ile Cys Ser Lys Glu           
        195                 200                 205                       

ggg att gaa aaa tac cat gcc gcc ttc cca gag gtc aga att gtt act        672
Gly Ile Glu Lys Tyr His Ala Ala Phe Pro Glu Val Arg Ile Val Thr           
    210                 215                 220                           

ggt gcc ctc gac aga ggt cta gat gaa aac aag tat cta gtt cca ggg        720
Gly Ala Leu Asp Arg Gly Leu Asp Glu Asn Lys Tyr Leu Val Pro Gly           
225                 230                 235                 240           

ttg ggt gac ttt ggt gac aga tac tac tgt gtt taa                        756
Leu Gly Asp Phe Gly Asp Arg Tyr Tyr Cys Val                               
                245                 250                                   


<210>  8
<211>  251
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Asn Pro Leu Phe Phe Leu Ala Ser Pro Phe Leu Tyr Leu Thr Tyr 
1               5                   10                  15      


Leu Ile Tyr Tyr Pro Asn Lys Gly Ser Phe Val Ser Lys Pro Arg Asn 
            20                  25                  30          


Leu Gln Lys Met Ser Ser Glu Pro Phe Lys Asn Val Tyr Leu Leu Pro 
        35                  40                  45              


Gln Thr Asn Gln Leu Leu Gly Leu Tyr Thr Ile Ile Arg Asn Lys Asn 
    50                  55                  60                  


Thr Thr Arg Pro Asp Phe Ile Phe Tyr Ser Asp Arg Ile Ile Arg Leu 
65                  70                  75                  80  


Leu Val Glu Glu Gly Leu Asn His Leu Pro Val Gln Lys Gln Ile Val 
                85                  90                  95      


Glu Thr Asp Thr Asn Glu Asn Phe Glu Gly Val Ser Phe Met Gly Lys 
            100                 105                 110         


Ile Cys Gly Val Ser Ile Val Arg Ala Gly Glu Ser Met Glu Gln Gly 
        115                 120                 125             


Leu Arg Asp Cys Cys Arg Ser Val Arg Ile Gly Lys Ile Leu Ile Gln 
    130                 135                 140                 


Arg Asp Glu Glu Thr Ala Leu Pro Lys Leu Phe Tyr Glu Lys Leu Pro 
145                 150                 155                 160 


Glu Asp Ile Ser Glu Arg Tyr Val Phe Leu Leu Asp Pro Met Leu Ala 
                165                 170                 175     


Thr Gly Gly Ser Ala Ile Met Ala Thr Glu Val Leu Ile Lys Arg Gly 
            180                 185                 190         


Val Lys Pro Glu Arg Ile Tyr Phe Leu Asn Leu Ile Cys Ser Lys Glu 
        195                 200                 205             


Gly Ile Glu Lys Tyr His Ala Ala Phe Pro Glu Val Arg Ile Val Thr 
    210                 215                 220                 


Gly Ala Leu Asp Arg Gly Leu Asp Glu Asn Lys Tyr Leu Val Pro Gly 
225                 230                 235                 240 


Leu Gly Asp Phe Gly Asp Arg Tyr Tyr Cys Val 
                245                 250     


<210>  9
<211>  1443
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(1443)

<400>  9
atg gct gtt gct cgt gct gct ctt ggt cct ctt gtt act ggt ctt tat         48
Met Ala Val Ala Arg Ala Ala Leu Gly Pro Leu Val Thr Gly Leu Tyr           
1               5                   10                  15                

gat gtt caa gct ttt aaa ttt ggt gat ttt gtt ctt aaa tct ggt ctt         96
Asp Val Gln Ala Phe Lys Phe Gly Asp Phe Val Leu Lys Ser Gly Leu           
            20                  25                  30                    

tct tct cct att tat att gat ctt cgt ggt att gtt tct cgt cct cgt        144
Ser Ser Pro Ile Tyr Ile Asp Leu Arg Gly Ile Val Ser Arg Pro Arg           
        35                  40                  45                        

ctt ctt tct caa gtt gct gat att ctt ttt caa act gct caa aat gct        192
Leu Leu Ser Gln Val Ala Asp Ile Leu Phe Gln Thr Ala Gln Asn Ala           
    50                  55                  60                            

ggt att tct ttt gat act gtt tgt ggt gtt cct tat act gct ctt cct        240
Gly Ile Ser Phe Asp Thr Val Cys Gly Val Pro Tyr Thr Ala Leu Pro           
65                  70                  75                  80            

ctt gct act gtt att tgt tct act aat caa att cct atg ctt att cgt        288
Leu Ala Thr Val Ile Cys Ser Thr Asn Gln Ile Pro Met Leu Ile Arg           
                85                  90                  95                

cgt aaa gaa act aaa gat tat ggt act aaa cgt ctt gtt gaa ggt act        336
Arg Lys Glu Thr Lys Asp Tyr Gly Thr Lys Arg Leu Val Glu Gly Thr           
            100                 105                 110                   

att aat cct ggt gaa act tgt ctt att att gaa gat gtt gtt act tct        384
Ile Asn Pro Gly Glu Thr Cys Leu Ile Ile Glu Asp Val Val Thr Ser           
        115                 120                 125                       

ggt tct tct gtt ctt gaa act gtt gaa gtt ctt caa aaa gaa ggt ctt        432
Gly Ser Ser Val Leu Glu Thr Val Glu Val Leu Gln Lys Glu Gly Leu           
    130                 135                 140                           

aaa gtt act gat gct att gtt ctt ctt gat cgt gaa caa ggt ggt aaa        480
Lys Val Thr Asp Ala Ile Val Leu Leu Asp Arg Glu Gln Gly Gly Lys           
145                 150                 155                 160           

gat aaa ctt caa gct cat ggt att cgt ctt cat tct gtt tgt act ctt        528
Asp Lys Leu Gln Ala His Gly Ile Arg Leu His Ser Val Cys Thr Leu           
                165                 170                 175               

tct aaa atg ctt gaa att ctt gaa caa caa aaa aaa gtt gat gct gaa        576
Ser Lys Met Leu Glu Ile Leu Glu Gln Gln Lys Lys Val Asp Ala Glu           
            180                 185                 190                   

act gtt ggt cgt gtt aaa cgt ttt att caa gaa aat gtt ttt gtt gct        624
Thr Val Gly Arg Val Lys Arg Phe Ile Gln Glu Asn Val Phe Val Ala           
        195                 200                 205                       

gct aat cat aat ggt tct cct ctt tct att aaa gaa gct cct aaa gaa        672
Ala Asn His Asn Gly Ser Pro Leu Ser Ile Lys Glu Ala Pro Lys Glu           
    210                 215                 220                           

ctt tct ttt ggt gct cgt gct gaa ctt cct cgt att cat cct gtt gct        720
Leu Ser Phe Gly Ala Arg Ala Glu Leu Pro Arg Ile His Pro Val Ala           
225                 230                 235                 240           

tct aaa ctt ctt cgt ctt atg caa aaa aaa gaa act aat ctt tgt ctt        768
Ser Lys Leu Leu Arg Leu Met Gln Lys Lys Glu Thr Asn Leu Cys Leu           
                245                 250                 255               

tct gct gat gtt tct ctt gct cgt gaa ctt ctt caa ctt gct gat gct        816
Ser Ala Asp Val Ser Leu Ala Arg Glu Leu Leu Gln Leu Ala Asp Ala           
            260                 265                 270                   

ctt ggt cct tct att tgt atg ctt aaa act cat gtt gat att ctt aat        864
Leu Gly Pro Ser Ile Cys Met Leu Lys Thr His Val Asp Ile Leu Asn           
        275                 280                 285                       

gat ttt act ctt gat gtt atg aaa gaa ctt att act ctt gct aaa tgt        912
Asp Phe Thr Leu Asp Val Met Lys Glu Leu Ile Thr Leu Ala Lys Cys           
    290                 295                 300                           

cat gaa ttt ctt att ttt gaa gat cgt aaa ttt gct gat att ggt aat        960
His Glu Phe Leu Ile Phe Glu Asp Arg Lys Phe Ala Asp Ile Gly Asn           
305                 310                 315                 320           

act gtt aaa aaa caa tat gaa ggt ggt att ttt aaa att gct tct tgg       1008
Thr Val Lys Lys Gln Tyr Glu Gly Gly Ile Phe Lys Ile Ala Ser Trp           
                325                 330                 335               

gct gat ctt gtt aat gct cat gtt gtt cct ggt tct ggt gtt gtt aaa       1056
Ala Asp Leu Val Asn Ala His Val Val Pro Gly Ser Gly Val Val Lys           
            340                 345                 350                   

ggt ctt caa gaa gtt ggt ctt cct ctt cat cgt ggt tgt ctt ctt att       1104
Gly Leu Gln Glu Val Gly Leu Pro Leu His Arg Gly Cys Leu Leu Ile           
        355                 360                 365                       

gct gaa atg tct tct act ggt tct ctt gct act ggt gat tat act cgt       1152
Ala Glu Met Ser Ser Thr Gly Ser Leu Ala Thr Gly Asp Tyr Thr Arg           
    370                 375                 380                           

gct gct gtt cgt atg gct gaa gaa cat tct gaa ttt gtt gtt ggt ttt       1200
Ala Ala Val Arg Met Ala Glu Glu His Ser Glu Phe Val Val Gly Phe           
385                 390                 395                 400           

att tct ggt tct cgt gtt tct atg aaa cct gaa ttt ctt cat ctt act       1248
Ile Ser Gly Ser Arg Val Ser Met Lys Pro Glu Phe Leu His Leu Thr           
                405                 410                 415               

cct ggt gtt caa ctt gaa gct ggt ggt gat aat ctt ggt caa caa tat       1296
Pro Gly Val Gln Leu Glu Ala Gly Gly Asp Asn Leu Gly Gln Gln Tyr           
            420                 425                 430                   

aat tct cct caa gaa gtt att ggt aaa cgt ggt tct gat att att att       1344
Asn Ser Pro Gln Glu Val Ile Gly Lys Arg Gly Ser Asp Ile Ile Ile           
        435                 440                 445                       

gtt ggt cgt ggt att att tct gct gct gat cgt ctt gaa gct gct gaa       1392
Val Gly Arg Gly Ile Ile Ser Ala Ala Asp Arg Leu Glu Ala Ala Glu           
    450                 455                 460                           

atg tat cgt aaa gct gct tgg gaa gct tat ctt tct cgt ctt ggt gtt       1440
Met Tyr Arg Lys Ala Ala Trp Glu Ala Tyr Leu Ser Arg Leu Gly Val           
465                 470                 475                 480           

taa                                                                   1443


<210>  10
<211>  480
<212>  PRT
<213>  homo sapiens

<400>  10

Met Ala Val Ala Arg Ala Ala Leu Gly Pro Leu Val Thr Gly Leu Tyr 
1               5                   10                  15      


Asp Val Gln Ala Phe Lys Phe Gly Asp Phe Val Leu Lys Ser Gly Leu 
            20                  25                  30          


Ser Ser Pro Ile Tyr Ile Asp Leu Arg Gly Ile Val Ser Arg Pro Arg 
        35                  40                  45              


Leu Leu Ser Gln Val Ala Asp Ile Leu Phe Gln Thr Ala Gln Asn Ala 
    50                  55                  60                  


Gly Ile Ser Phe Asp Thr Val Cys Gly Val Pro Tyr Thr Ala Leu Pro 
65                  70                  75                  80  


Leu Ala Thr Val Ile Cys Ser Thr Asn Gln Ile Pro Met Leu Ile Arg 
                85                  90                  95      


Arg Lys Glu Thr Lys Asp Tyr Gly Thr Lys Arg Leu Val Glu Gly Thr 
            100                 105                 110         


Ile Asn Pro Gly Glu Thr Cys Leu Ile Ile Glu Asp Val Val Thr Ser 
        115                 120                 125             


Gly Ser Ser Val Leu Glu Thr Val Glu Val Leu Gln Lys Glu Gly Leu 
    130                 135                 140                 


Lys Val Thr Asp Ala Ile Val Leu Leu Asp Arg Glu Gln Gly Gly Lys 
145                 150                 155                 160 


Asp Lys Leu Gln Ala His Gly Ile Arg Leu His Ser Val Cys Thr Leu 
                165                 170                 175     


Ser Lys Met Leu Glu Ile Leu Glu Gln Gln Lys Lys Val Asp Ala Glu 
            180                 185                 190         


Thr Val Gly Arg Val Lys Arg Phe Ile Gln Glu Asn Val Phe Val Ala 
        195                 200                 205             


Ala Asn His Asn Gly Ser Pro Leu Ser Ile Lys Glu Ala Pro Lys Glu 
    210                 215                 220                 


Leu Ser Phe Gly Ala Arg Ala Glu Leu Pro Arg Ile His Pro Val Ala 
225                 230                 235                 240 


Ser Lys Leu Leu Arg Leu Met Gln Lys Lys Glu Thr Asn Leu Cys Leu 
                245                 250                 255     


Ser Ala Asp Val Ser Leu Ala Arg Glu Leu Leu Gln Leu Ala Asp Ala 
            260                 265                 270         


Leu Gly Pro Ser Ile Cys Met Leu Lys Thr His Val Asp Ile Leu Asn 
        275                 280                 285             


Asp Phe Thr Leu Asp Val Met Lys Glu Leu Ile Thr Leu Ala Lys Cys 
    290                 295                 300                 


His Glu Phe Leu Ile Phe Glu Asp Arg Lys Phe Ala Asp Ile Gly Asn 
305                 310                 315                 320 


Thr Val Lys Lys Gln Tyr Glu Gly Gly Ile Phe Lys Ile Ala Ser Trp 
                325                 330                 335     


Ala Asp Leu Val Asn Ala His Val Val Pro Gly Ser Gly Val Val Lys 
            340                 345                 350         


Gly Leu Gln Glu Val Gly Leu Pro Leu His Arg Gly Cys Leu Leu Ile 
        355                 360                 365             


Ala Glu Met Ser Ser Thr Gly Ser Leu Ala Thr Gly Asp Tyr Thr Arg 
    370                 375                 380                 


Ala Ala Val Arg Met Ala Glu Glu His Ser Glu Phe Val Val Gly Phe 
385                 390                 395                 400 


Ile Ser Gly Ser Arg Val Ser Met Lys Pro Glu Phe Leu His Leu Thr 
                405                 410                 415     


Pro Gly Val Gln Leu Glu Ala Gly Gly Asp Asn Leu Gly Gln Gln Tyr 
            420                 425                 430         


Asn Ser Pro Gln Glu Val Ile Gly Lys Arg Gly Ser Asp Ile Ile Ile 
        435                 440                 445             


Val Gly Arg Gly Ile Ile Ser Ala Ala Asp Arg Leu Glu Ala Ala Glu 
    450                 455                 460                 


Met Tyr Arg Lys Ala Ala Trp Glu Ala Tyr Leu Ser Arg Leu Gly Val 
465                 470                 475                 480 


<210>  11
<211>  1227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion construct CDopt-UPRT


<220>
<221>  CDS
<222>  (1)..(1227)

<400>  11
atg gtg acc ggc ggc atg gcc tcc aag tgg gat caa aag ggc atg gat         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

atc gct tac gag gag gcc ctg ctg ggc tac aag gag ggc ggc gtg cct         96
Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

atc ggc ggc tgt ctg atc aac aac aag gac ggc agt gtg ctg ggc agg        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggc cac aac atg agg ttc cag aag ggc tcc gcc acc ctg cac ggc gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc acc ctg gag aac tgt ggc agg ctg gag ggc aag gtg tac aag        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gac acc acc ctg tac acc acc ctg tcc cct tgt gac atg tgt acc ggc        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gct atc atc atg tac ggc atc cct agg tgt gtg atc ggc gag aac gtg        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val           
            100                 105                 110                   

aac ttc aag tcc aag ggc gag aag tac ctg caa acc agg ggc cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtg gtg gtt gtt gac gat gag agg tgt aag aag ctg atg aag cag ttc        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe           
    130                 135                 140                           

atc gac gag agg cct cag gac tgg ttc gag gat atc ggc gag aac ccg        480
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Asn Pro           
145                 150                 155                 160           

tta ttc ttt ttg gct tct cca ttc ttg tac ctt aca tat ctt ata tat        528
Leu Phe Phe Leu Ala Ser Pro Phe Leu Tyr Leu Thr Tyr Leu Ile Tyr           
                165                 170                 175               

tat cca aac aaa ggg tct ttc gtt agc aaa cct aga aat ctg caa aaa        576
Tyr Pro Asn Lys Gly Ser Phe Val Ser Lys Pro Arg Asn Leu Gln Lys           
            180                 185                 190                   

atg tct tcg gaa cca ttt aag aac gtc tac ttg cta cct caa aca aac        624
Met Ser Ser Glu Pro Phe Lys Asn Val Tyr Leu Leu Pro Gln Thr Asn           
        195                 200                 205                       

caa ttg ctg ggt ttg tac acc atc atc aga aat aag aat aca act aga        672
Gln Leu Leu Gly Leu Tyr Thr Ile Ile Arg Asn Lys Asn Thr Thr Arg           
    210                 215                 220                           

cct gat ttc att ttc tac tcc gat aga atc atc aga ttg ttg gtt gaa        720
Pro Asp Phe Ile Phe Tyr Ser Asp Arg Ile Ile Arg Leu Leu Val Glu           
225                 230                 235                 240           

gaa ggt ttg aac cat cta cct gtg caa aag caa att gtg gaa act gac        768
Glu Gly Leu Asn His Leu Pro Val Gln Lys Gln Ile Val Glu Thr Asp           
                245                 250                 255               

acc aac gaa aac ttc gaa ggt gtc tca ttc atg ggt aaa atc tgt ggt        816
Thr Asn Glu Asn Phe Glu Gly Val Ser Phe Met Gly Lys Ile Cys Gly           
            260                 265                 270                   

gtt tcc att gtc aga gct ggt gaa tcg atg gag caa gga tta aga gac        864
Val Ser Ile Val Arg Ala Gly Glu Ser Met Glu Gln Gly Leu Arg Asp           
        275                 280                 285                       

tgt tgt agg tct gtg cgt atc ggt aaa att tta att caa agg gac gag        912
Cys Cys Arg Ser Val Arg Ile Gly Lys Ile Leu Ile Gln Arg Asp Glu           
    290                 295                 300                           

gag act gct tta cca aag tta ttc tac gaa aaa tta cca gag gat ata        960
Glu Thr Ala Leu Pro Lys Leu Phe Tyr Glu Lys Leu Pro Glu Asp Ile           
305                 310                 315                 320           

tct gaa agg tat gtc ttc cta tta gac cca atg ctg gcc acc ggt ggt       1008
Ser Glu Arg Tyr Val Phe Leu Leu Asp Pro Met Leu Ala Thr Gly Gly           
                325                 330                 335               

agt gct atc atg gct aca gaa gtc ttg att aag aga ggt gtt aag cca       1056
Ser Ala Ile Met Ala Thr Glu Val Leu Ile Lys Arg Gly Val Lys Pro           
            340                 345                 350                   

gag aga att tac ttc tta aac cta atc tgt agt aag gaa ggg att gaa       1104
Glu Arg Ile Tyr Phe Leu Asn Leu Ile Cys Ser Lys Glu Gly Ile Glu           
        355                 360                 365                       

aaa tac cat gcc gcc ttc cca gag gtc aga att gtt act ggt gcc ctc       1152
Lys Tyr His Ala Ala Phe Pro Glu Val Arg Ile Val Thr Gly Ala Leu           
    370                 375                 380                           

gac aga ggt cta gat gaa aac aag tat cta gtt cca ggg ttg ggt gac       1200
Asp Arg Gly Leu Asp Glu Asn Lys Tyr Leu Val Pro Gly Leu Gly Asp           
385                 390                 395                 400           

ttt ggt gac aga tac tac tgt gtt taa                                   1227
Phe Gly Asp Arg Tyr Tyr Cys Val                                           
                405                                                       


<210>  12
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Asn Pro 
145                 150                 155                 160 


Leu Phe Phe Leu Ala Ser Pro Phe Leu Tyr Leu Thr Tyr Leu Ile Tyr 
                165                 170                 175     


Tyr Pro Asn Lys Gly Ser Phe Val Ser Lys Pro Arg Asn Leu Gln Lys 
            180                 185                 190         


Met Ser Ser Glu Pro Phe Lys Asn Val Tyr Leu Leu Pro Gln Thr Asn 
        195                 200                 205             


Gln Leu Leu Gly Leu Tyr Thr Ile Ile Arg Asn Lys Asn Thr Thr Arg 
    210                 215                 220                 


Pro Asp Phe Ile Phe Tyr Ser Asp Arg Ile Ile Arg Leu Leu Val Glu 
225                 230                 235                 240 


Glu Gly Leu Asn His Leu Pro Val Gln Lys Gln Ile Val Glu Thr Asp 
                245                 250                 255     


Thr Asn Glu Asn Phe Glu Gly Val Ser Phe Met Gly Lys Ile Cys Gly 
            260                 265                 270         


Val Ser Ile Val Arg Ala Gly Glu Ser Met Glu Gln Gly Leu Arg Asp 
        275                 280                 285             


Cys Cys Arg Ser Val Arg Ile Gly Lys Ile Leu Ile Gln Arg Asp Glu 
    290                 295                 300                 


Glu Thr Ala Leu Pro Lys Leu Phe Tyr Glu Lys Leu Pro Glu Asp Ile 
305                 310                 315                 320 


Ser Glu Arg Tyr Val Phe Leu Leu Asp Pro Met Leu Ala Thr Gly Gly 
                325                 330                 335     


Ser Ala Ile Met Ala Thr Glu Val Leu Ile Lys Arg Gly Val Lys Pro 
            340                 345                 350         


Glu Arg Ile Tyr Phe Leu Asn Leu Ile Cys Ser Lys Glu Gly Ile Glu 
        355                 360                 365             


Lys Tyr His Ala Ala Phe Pro Glu Val Arg Ile Val Thr Gly Ala Leu 
    370                 375                 380                 


Asp Arg Gly Leu Asp Glu Asn Lys Tyr Leu Val Pro Gly Leu Gly Asp 
385                 390                 395                 400 


Phe Gly Asp Arg Tyr Tyr Cys Val 
                405             


<210>  13
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion construction - CDopt - linker - UPRT


<220>
<221>  CDS
<222>  (1)..(1287)

<400>  13
atg gtg acc ggc ggc atg gcc tcc aag tgg gat caa aag ggc atg gat         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

atc gct tac gag gag gcc ctg ctg ggc tac aag gag ggc ggc gtg cct         96
Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

atc ggc ggc tgt ctg atc aac aac aag gac ggc agt gtg ctg ggc agg        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggc cac aac atg agg ttc cag aag ggc tcc gcc acc ctg cac ggc gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc acc ctg gag aac tgt ggc agg ctg gag ggc aag gtg tac aag        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gac acc acc ctg tac acc acc ctg tcc cct tgt gac atg tgt acc ggc        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gct atc atc atg tac ggc atc cct agg tgt gtg atc ggc gag aac gtg        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val           
            100                 105                 110                   

aac ttc aag tcc aag ggc gag aag tac ctg caa acc agg ggc cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtg gtg gtt gtt gac gat gag agg tgt aag aag ctg atg aag cag ttc        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe           
    130                 135                 140                           

atc gac gag agg cct cag gac tgg ttc gag gat atc ggc gag tcc ggc        480
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ser Gly           
145                 150                 155                 160           

ggc ggc gcc tcc ggc ggc ggc gcc tcc ggc ggc ggc gcc tcc ggc ggc        528
Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly           
                165                 170                 175               

ggc gcc aac ccg tta ttc ttt ttg gct tct cca ttc ttg tac ctt aca        576
Gly Ala Asn Pro Leu Phe Phe Leu Ala Ser Pro Phe Leu Tyr Leu Thr           
            180                 185                 190                   

tat ctt ata tat tat cca aac aaa ggg tct ttc gtt agc aaa cct aga        624
Tyr Leu Ile Tyr Tyr Pro Asn Lys Gly Ser Phe Val Ser Lys Pro Arg           
        195                 200                 205                       

aat ctg caa aaa atg tct tcg gaa cca ttt aag aac gtc tac ttg cta        672
Asn Leu Gln Lys Met Ser Ser Glu Pro Phe Lys Asn Val Tyr Leu Leu           
    210                 215                 220                           

cct caa aca aac caa ttg ctg ggt ttg tac acc atc atc aga aat aag        720
Pro Gln Thr Asn Gln Leu Leu Gly Leu Tyr Thr Ile Ile Arg Asn Lys           
225                 230                 235                 240           

aat aca act aga cct gat ttc att ttc tac tcc gat aga atc atc aga        768
Asn Thr Thr Arg Pro Asp Phe Ile Phe Tyr Ser Asp Arg Ile Ile Arg           
                245                 250                 255               

ttg ttg gtt gaa gaa ggt ttg aac cat cta cct gtg caa aag caa att        816
Leu Leu Val Glu Glu Gly Leu Asn His Leu Pro Val Gln Lys Gln Ile           
            260                 265                 270                   

gtg gaa act gac acc aac gaa aac ttc gaa ggt gtc tca ttc atg ggt        864
Val Glu Thr Asp Thr Asn Glu Asn Phe Glu Gly Val Ser Phe Met Gly           
        275                 280                 285                       

aaa atc tgt ggt gtt tcc att gtc aga gct ggt gaa tcg atg gag caa        912
Lys Ile Cys Gly Val Ser Ile Val Arg Ala Gly Glu Ser Met Glu Gln           
    290                 295                 300                           

gga tta aga gac tgt tgt agg tct gtg cgt atc ggt aaa att tta att        960
Gly Leu Arg Asp Cys Cys Arg Ser Val Arg Ile Gly Lys Ile Leu Ile           
305                 310                 315                 320           

caa agg gac gag gag act gct tta cca aag tta ttc tac gaa aaa tta       1008
Gln Arg Asp Glu Glu Thr Ala Leu Pro Lys Leu Phe Tyr Glu Lys Leu           
                325                 330                 335               

cca gag gat ata tct gaa agg tat gtc ttc cta tta gac cca atg ctg       1056
Pro Glu Asp Ile Ser Glu Arg Tyr Val Phe Leu Leu Asp Pro Met Leu           
            340                 345                 350                   

gcc acc ggt ggt agt gct atc atg gct aca gaa gtc ttg att aag aga       1104
Ala Thr Gly Gly Ser Ala Ile Met Ala Thr Glu Val Leu Ile Lys Arg           
        355                 360                 365                       

ggt gtt aag cca gag aga att tac ttc tta aac cta atc tgt agt aag       1152
Gly Val Lys Pro Glu Arg Ile Tyr Phe Leu Asn Leu Ile Cys Ser Lys           
    370                 375                 380                           

gaa ggg att gaa aaa tac cat gcc gcc ttc cca gag gtc aga att gtt       1200
Glu Gly Ile Glu Lys Tyr His Ala Ala Phe Pro Glu Val Arg Ile Val           
385                 390                 395                 400           

act ggt gcc ctc gac aga ggt cta gat gaa aac aag tat cta gtt cca       1248
Thr Gly Ala Leu Asp Arg Gly Leu Asp Glu Asn Lys Tyr Leu Val Pro           
                405                 410                 415               

ggg ttg ggt gac ttt ggt gac aga tac tac tgt gtt taa                   1287
Gly Leu Gly Asp Phe Gly Asp Arg Tyr Tyr Cys Val                           
            420                 425                                       


<210>  14
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly 
                165                 170                 175     


Gly Ala Asn Pro Leu Phe Phe Leu Ala Ser Pro Phe Leu Tyr Leu Thr 
            180                 185                 190         


Tyr Leu Ile Tyr Tyr Pro Asn Lys Gly Ser Phe Val Ser Lys Pro Arg 
        195                 200                 205             


Asn Leu Gln Lys Met Ser Ser Glu Pro Phe Lys Asn Val Tyr Leu Leu 
    210                 215                 220                 


Pro Gln Thr Asn Gln Leu Leu Gly Leu Tyr Thr Ile Ile Arg Asn Lys 
225                 230                 235                 240 


Asn Thr Thr Arg Pro Asp Phe Ile Phe Tyr Ser Asp Arg Ile Ile Arg 
                245                 250                 255     


Leu Leu Val Glu Glu Gly Leu Asn His Leu Pro Val Gln Lys Gln Ile 
            260                 265                 270         


Val Glu Thr Asp Thr Asn Glu Asn Phe Glu Gly Val Ser Phe Met Gly 
        275                 280                 285             


Lys Ile Cys Gly Val Ser Ile Val Arg Ala Gly Glu Ser Met Glu Gln 
    290                 295                 300                 


Gly Leu Arg Asp Cys Cys Arg Ser Val Arg Ile Gly Lys Ile Leu Ile 
305                 310                 315                 320 


Gln Arg Asp Glu Glu Thr Ala Leu Pro Lys Leu Phe Tyr Glu Lys Leu 
                325                 330                 335     


Pro Glu Asp Ile Ser Glu Arg Tyr Val Phe Leu Leu Asp Pro Met Leu 
            340                 345                 350         


Ala Thr Gly Gly Ser Ala Ile Met Ala Thr Glu Val Leu Ile Lys Arg 
        355                 360                 365             


Gly Val Lys Pro Glu Arg Ile Tyr Phe Leu Asn Leu Ile Cys Ser Lys 
    370                 375                 380                 


Glu Gly Ile Glu Lys Tyr His Ala Ala Phe Pro Glu Val Arg Ile Val 
385                 390                 395                 400 


Thr Gly Ala Leu Asp Arg Gly Leu Asp Glu Asn Lys Tyr Leu Val Pro 
                405                 410                 415     


Gly Leu Gly Asp Phe Gly Asp Arg Tyr Tyr Cys Val 
            420                 425             


<210>  15
<211>  1200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion Construct - CDopt3 - OPRT


<220>
<221>  CDS
<222>  (1)..(1200)

<400>  15
atg gtg acc ggc ggc atg gcc tcc aag tgg gat caa aag ggc atg gat         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

atc gct tac gag gag gcc ctg ctg ggc tac aag gag ggc ggc gtg cct         96
Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

atc ggc ggc tgt ctg atc aac aac aag gac ggc agt gtg ctg ggc agg        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggc cac aac atg agg ttc cag aag ggc tcc gcc acc ctg cac ggc gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc acc ctg gag aac tgt ggc agg ctg gag ggc aag gtg tac aag        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gac acc acc ctg tac acc acc ctg tcc cct tgt gac atg tgt acc ggc        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gct atc atc atg tac ggc atc cct agg tgt gtg atc ggc gag aac gtg        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val           
            100                 105                 110                   

aac ttc aag tcc aag ggc gag aag tac ctg caa acc agg ggc cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtg gtg gtt gtt gac gat gag agg tgt aag aag ctg atg aag cag ttc        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe           
    130                 135                 140                           

atc gac gag agg cct cag gac tgg ttc gag gat atc ggc gag gcg gtc        480
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ala Val           
145                 150                 155                 160           

gct cgt gca gct ttg ggg cca ttg gtg acg ggt ctg tac gac gtg cag        528
Ala Arg Ala Ala Leu Gly Pro Leu Val Thr Gly Leu Tyr Asp Val Gln           
                165                 170                 175               

gct ttc aag ttt ggg gac ttc gtg ctg aag agc ggg ctt tcc tcc ccc        576
Ala Phe Lys Phe Gly Asp Phe Val Leu Lys Ser Gly Leu Ser Ser Pro           
            180                 185                 190                   

atc tac atc gat ctg cgg ggc atc gtg tct cga ccg cgt ctt ctg agt        624
Ile Tyr Ile Asp Leu Arg Gly Ile Val Ser Arg Pro Arg Leu Leu Ser           
        195                 200                 205                       

cag gtt gca gat att tta ttc caa act gcc caa aat gca ggc atc agt        672
Gln Val Ala Asp Ile Leu Phe Gln Thr Ala Gln Asn Ala Gly Ile Ser           
    210                 215                 220                           

ttt gac acc gtg tgt gga gtg cct tat aca gct ttg cca ttg gct aca        720
Phe Asp Thr Val Cys Gly Val Pro Tyr Thr Ala Leu Pro Leu Ala Thr           
225                 230                 235                 240           

gtt atc tgt tca acc aat caa att cca atg ctt att aga agg aaa gaa        768
Val Ile Cys Ser Thr Asn Gln Ile Pro Met Leu Ile Arg Arg Lys Glu           
                245                 250                 255               

aca aag gat tat gga act aag cgt ctt gta gaa gga act att aat cca        816
Thr Lys Asp Tyr Gly Thr Lys Arg Leu Val Glu Gly Thr Ile Asn Pro           
            260                 265                 270                   

gga gaa acc tgt tta atc att gaa gat gtt gtc acc agt gga tct agt        864
Gly Glu Thr Cys Leu Ile Ile Glu Asp Val Val Thr Ser Gly Ser Ser           
        275                 280                 285                       

gtt ttg gaa act gtt gag gtt ctt cag aag gag ggc ttg aag gtc act        912
Val Leu Glu Thr Val Glu Val Leu Gln Lys Glu Gly Leu Lys Val Thr           
    290                 295                 300                           

gat gcc ata gtg ctg ttg gac aga gag cag gga ggc aag gac aag ttg        960
Asp Ala Ile Val Leu Leu Asp Arg Glu Gln Gly Gly Lys Asp Lys Leu           
305                 310                 315                 320           

cag gcg cac ggg atc cgc ctc cac tca gtg tgt aca ttg tcc aaa atg       1008
Gln Ala His Gly Ile Arg Leu His Ser Val Cys Thr Leu Ser Lys Met           
                325                 330                 335               

ctg gag att ctc gag cag cag aaa aaa gtt gat gct gag aca gtt ggg       1056
Leu Glu Ile Leu Glu Gln Gln Lys Lys Val Asp Ala Glu Thr Val Gly           
            340                 345                 350                   

aga gtg aag agg ttt att cag gag aat gtc ttt gtg gca gcg aat cat       1104
Arg Val Lys Arg Phe Ile Gln Glu Asn Val Phe Val Ala Ala Asn His           
        355                 360                 365                       

aat ggt tct ccc ctt tct ata aag gaa gca ccc aaa gaa ctc agc ttc       1152
Asn Gly Ser Pro Leu Ser Ile Lys Glu Ala Pro Lys Glu Leu Ser Phe           
    370                 375                 380                           

ggt gca cgt gca gag ctg ccc agg atc cac cca gtt gca tcg aag taa       1200
Gly Ala Arg Ala Glu Leu Pro Arg Ile His Pro Val Ala Ser Lys               
385                 390                 395                               


<210>  16
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ala Val 
145                 150                 155                 160 


Ala Arg Ala Ala Leu Gly Pro Leu Val Thr Gly Leu Tyr Asp Val Gln 
                165                 170                 175     


Ala Phe Lys Phe Gly Asp Phe Val Leu Lys Ser Gly Leu Ser Ser Pro 
            180                 185                 190         


Ile Tyr Ile Asp Leu Arg Gly Ile Val Ser Arg Pro Arg Leu Leu Ser 
        195                 200                 205             


Gln Val Ala Asp Ile Leu Phe Gln Thr Ala Gln Asn Ala Gly Ile Ser 
    210                 215                 220                 


Phe Asp Thr Val Cys Gly Val Pro Tyr Thr Ala Leu Pro Leu Ala Thr 
225                 230                 235                 240 


Val Ile Cys Ser Thr Asn Gln Ile Pro Met Leu Ile Arg Arg Lys Glu 
                245                 250                 255     


Thr Lys Asp Tyr Gly Thr Lys Arg Leu Val Glu Gly Thr Ile Asn Pro 
            260                 265                 270         


Gly Glu Thr Cys Leu Ile Ile Glu Asp Val Val Thr Ser Gly Ser Ser 
        275                 280                 285             


Val Leu Glu Thr Val Glu Val Leu Gln Lys Glu Gly Leu Lys Val Thr 
    290                 295                 300                 


Asp Ala Ile Val Leu Leu Asp Arg Glu Gln Gly Gly Lys Asp Lys Leu 
305                 310                 315                 320 


Gln Ala His Gly Ile Arg Leu His Ser Val Cys Thr Leu Ser Lys Met 
                325                 330                 335     


Leu Glu Ile Leu Glu Gln Gln Lys Lys Val Asp Ala Glu Thr Val Gly 
            340                 345                 350         


Arg Val Lys Arg Phe Ile Gln Glu Asn Val Phe Val Ala Ala Asn His 
        355                 360                 365             


Asn Gly Ser Pro Leu Ser Ile Lys Glu Ala Pro Lys Glu Leu Ser Phe 
    370                 375                 380                 


Gly Ala Arg Ala Glu Leu Pro Arg Ile His Pro Val Ala Ser Lys 
385                 390                 395                 


<210>  17
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion Construct - CDopt3 - linker - OPRT


<220>
<221>  CDS
<222>  (1)..(1260)

<400>  17
atg gtg acc ggc ggc atg gcc tcc aag tgg gat caa aag ggc atg gat         48
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp           
1               5                   10                  15                

atc gct tac gag gag gcc ctg ctg ggc tac aag gag ggc ggc gtg cct         96
Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro           
            20                  25                  30                    

atc ggc ggc tgt ctg atc aac aac aag gac ggc agt gtg ctg ggc agg        144
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg           
        35                  40                  45                        

ggc cac aac atg agg ttc cag aag ggc tcc gcc acc ctg cac ggc gag        192
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu           
    50                  55                  60                            

atc tcc acc ctg gag aac tgt ggc agg ctg gag ggc aag gtg tac aag        240
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys           
65                  70                  75                  80            

gac acc acc ctg tac acc acc ctg tcc cct tgt gac atg tgt acc ggc        288
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly           
                85                  90                  95                

gct atc atc atg tac ggc atc cct agg tgt gtg atc ggc gag aac gtg        336
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val           
            100                 105                 110                   

aac ttc aag tcc aag ggc gag aag tac ctg caa acc agg ggc cac gag        384
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu           
        115                 120                 125                       

gtg gtg gtt gtt gac gat gag agg tgt aag aag ctg atg aag cag ttc        432
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe           
    130                 135                 140                           

atc gac gag agg cct cag gac tgg ttc gag gat atc ggc gag tcc ggc        480
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ser Gly           
145                 150                 155                 160           

ggc ggc gcc tcc ggc ggc ggc gcc tcc ggc ggc ggc gcc tcc ggc ggc        528
Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly           
                165                 170                 175               

ggc gcc gcg gtc gct cgt gca gct ttg ggg cca ttg gtg acg ggt ctg        576
Gly Ala Ala Val Ala Arg Ala Ala Leu Gly Pro Leu Val Thr Gly Leu           
            180                 185                 190                   

tac gac gtg cag gct ttc aag ttt ggg gac ttc gtg ctg aag agc ggg        624
Tyr Asp Val Gln Ala Phe Lys Phe Gly Asp Phe Val Leu Lys Ser Gly           
        195                 200                 205                       

ctt tcc tcc ccc atc tac atc gat ctg cgg ggc atc gtg tct cga ccg        672
Leu Ser Ser Pro Ile Tyr Ile Asp Leu Arg Gly Ile Val Ser Arg Pro           
    210                 215                 220                           

cgt ctt ctg agt cag gtt gca gat att tta ttc caa act gcc caa aat        720
Arg Leu Leu Ser Gln Val Ala Asp Ile Leu Phe Gln Thr Ala Gln Asn           
225                 230                 235                 240           

gca ggc atc agt ttt gac acc gtg tgt gga gtg cct tat aca gct ttg        768
Ala Gly Ile Ser Phe Asp Thr Val Cys Gly Val Pro Tyr Thr Ala Leu           
                245                 250                 255               

cca ttg gct aca gtt atc tgt tca acc aat caa att cca atg ctt att        816
Pro Leu Ala Thr Val Ile Cys Ser Thr Asn Gln Ile Pro Met Leu Ile           
            260                 265                 270                   

aga agg aaa gaa aca aag gat tat gga act aag cgt ctt gta gaa gga        864
Arg Arg Lys Glu Thr Lys Asp Tyr Gly Thr Lys Arg Leu Val Glu Gly           
        275                 280                 285                       

act att aat cca gga gaa acc tgt tta atc att gaa gat gtt gtc acc        912
Thr Ile Asn Pro Gly Glu Thr Cys Leu Ile Ile Glu Asp Val Val Thr           
    290                 295                 300                           

agt gga tct agt gtt ttg gaa act gtt gag gtt ctt cag aag gag ggc        960
Ser Gly Ser Ser Val Leu Glu Thr Val Glu Val Leu Gln Lys Glu Gly           
305                 310                 315                 320           

ttg aag gtc act gat gcc ata gtg ctg ttg gac aga gag cag gga ggc       1008
Leu Lys Val Thr Asp Ala Ile Val Leu Leu Asp Arg Glu Gln Gly Gly           
                325                 330                 335               

aag gac aag ttg cag gcg cac ggg atc cgc ctc cac tca gtg tgt aca       1056
Lys Asp Lys Leu Gln Ala His Gly Ile Arg Leu His Ser Val Cys Thr           
            340                 345                 350                   

ttg tcc aaa atg ctg gag att ctc gag cag cag aaa aaa gtt gat gct       1104
Leu Ser Lys Met Leu Glu Ile Leu Glu Gln Gln Lys Lys Val Asp Ala           
        355                 360                 365                       

gag aca gtt ggg aga gtg aag agg ttt att cag gag aat gtc ttt gtg       1152
Glu Thr Val Gly Arg Val Lys Arg Phe Ile Gln Glu Asn Val Phe Val           
    370                 375                 380                           

gca gcg aat cat aat ggt tct ccc ctt tct ata aag gaa gca ccc aaa       1200
Ala Ala Asn His Asn Gly Ser Pro Leu Ser Ile Lys Glu Ala Pro Lys           
385                 390                 395                 400           

gaa ctc agc ttc ggt gca cgt gca gag ctg ccc agg atc cac cca gtt       1248
Glu Leu Ser Phe Gly Ala Arg Ala Glu Leu Pro Arg Ile His Pro Val           
                405                 410                 415               

gca tcg aag taa                                                       1260
Ala Ser Lys                                                               
                                                                          


<210>  18
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Leu Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Ile Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Leu Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly Gly Ala Ser Gly Gly 
                165                 170                 175     


Gly Ala Ala Val Ala Arg Ala Ala Leu Gly Pro Leu Val Thr Gly Leu 
            180                 185                 190         


Tyr Asp Val Gln Ala Phe Lys Phe Gly Asp Phe Val Leu Lys Ser Gly 
        195                 200                 205             


Leu Ser Ser Pro Ile Tyr Ile Asp Leu Arg Gly Ile Val Ser Arg Pro 
    210                 215                 220                 


Arg Leu Leu Ser Gln Val Ala Asp Ile Leu Phe Gln Thr Ala Gln Asn 
225                 230                 235                 240 


Ala Gly Ile Ser Phe Asp Thr Val Cys Gly Val Pro Tyr Thr Ala Leu 
                245                 250                 255     


Pro Leu Ala Thr Val Ile Cys Ser Thr Asn Gln Ile Pro Met Leu Ile 
            260                 265                 270         


Arg Arg Lys Glu Thr Lys Asp Tyr Gly Thr Lys Arg Leu Val Glu Gly 
        275                 280                 285             


Thr Ile Asn Pro Gly Glu Thr Cys Leu Ile Ile Glu Asp Val Val Thr 
    290                 295                 300                 


Ser Gly Ser Ser Val Leu Glu Thr Val Glu Val Leu Gln Lys Glu Gly 
305                 310                 315                 320 


Leu Lys Val Thr Asp Ala Ile Val Leu Leu Asp Arg Glu Gln Gly Gly 
                325                 330                 335     


Lys Asp Lys Leu Gln Ala His Gly Ile Arg Leu His Ser Val Cys Thr 
            340                 345                 350         


Leu Ser Lys Met Leu Glu Ile Leu Glu Gln Gln Lys Lys Val Asp Ala 
        355                 360                 365             


Glu Thr Val Gly Arg Val Lys Arg Phe Ile Gln Glu Asn Val Phe Val 
    370                 375                 380                 


Ala Ala Asn His Asn Gly Ser Pro Leu Ser Ile Lys Glu Ala Pro Lys 
385                 390                 395                 400 


Glu Leu Ser Phe Gly Ala Arg Ala Glu Leu Pro Arg Ile His Pro Val 
                405                 410                 415     


Ala Ser Lys 
            


<210>  19
<211>  11892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RCR Vector - pAC3-yCD2

<400>  19
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cggcgccagt cctccgattg      600

actgagtcgc ccgggtaccc gtgtatccaa taaaccctct tgcagttgca tccgacttgt      660

ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccgtc agcgggggtc      720

tttcatttgg gggctcgtcc gggatcggga gacccctgcc cagggaccac cgacccacca      780

ccgggaggta agctggccag caacttatct gtgtctgtcc gattgtctag tgtctatgac      840

tgattttatg cgcctgcgtc ggtactagtt agctaactag ctctgtatct ggcggacccg      900

tggtggaact gacgagttcg gaacacccgg ccgcaaccct gggagacgtc ccagggactt      960

cgggggccgt ttttgtggcc cgacctgagt ccaaaaatcc cgatcgtttt ggactctttg     1020

gtgcaccccc cttagaggag ggatatgtgg ttctggtagg agacgagaac ctaaaacagt     1080

tcccgcctcc gtctgaattt ttgctttcgg tttgggaccg aagccgcgcc gcgcgtcttg     1140

tctgctgcag catcgttctg tgttgtctct gtctgactgt gtttctgtat ttgtctgaga     1200

atatgggcca gactgttacc actcccttaa gtttgacctt aggtcactgg aaagatgtcg     1260

agcggatcgc tcacaaccag tcggtagatg tcaagaagag acgttgggtt accttctgct     1320

ctgcagaatg gccaaccttt aacgtcggat ggccgcgaga cggcaccttt aaccgagacc     1380

tcatcaccca ggttaagatc aaggtctttt cacctggccc gcatggacac ccagaccagg     1440

tcccctacat cgtgacctgg gaagccttgg cttttgaccc ccctccctgg gtcaagccct     1500

ttgtacaccc taagcctccg cctcctcttc ctccatccgc cccgtctctc ccccttgaac     1560

ctcctcgttc gaccccgcct cgatcctccc tttatccagc cctcactcct tctctaggcg     1620

ccaaacctaa acctcaagtt ctttctgaca gtggggggcc gctcatcgac ctacttacag     1680

aagacccccc gccttatagg gacccaagac cacccccttc cgacagggac ggaaatggtg     1740

gagaagcgac ccctgcggga gaggcaccgg acccctcccc aatggcatct cgcctacgtg     1800

ggagacggga gccccctgtg gccgactcca ctacctcgca ggcattcccc ctccgcgcag     1860

gaggaaacgg acagcttcaa tactggccgt tctcctcttc tgacctttac aactggaaaa     1920

ataataaccc ttctttttct gaagatccag gtaaactgac agctctgatc gagtctgttc     1980

tcatcaccca tcagcccacc tgggacgact gtcagcagct gttggggact ctgctgaccg     2040

gagaagaaaa acaacgggtg ctcttagagg ctagaaaggc ggtgcggggc gatgatgggc     2100

gccccactca actgcccaat gaagtcgatg ccgcttttcc cctcgagcgc ccagactggg     2160

attacaccac ccaggcaggt aggaaccacc tagtccacta tcgccagttg ctcctagcgg     2220

gtctccaaaa cgcgggcaga agccccacca atttggccaa ggtaaaagga ataacacaag     2280

ggcccaatga gtctccctcg gccttcctag agagacttaa ggaagcctat cgcaggtaca     2340

ctccttatga ccctgaggac ccagggcaag aaactaatgt gtctatgtct ttcatttggc     2400

agtctgcccc agacattggg agaaagttag agaggttaga agatttaaaa aacaagacgc     2460

ttggagattt ggttagagag gcagaaaaga tctttaataa acgagaaacc ccggaagaaa     2520

gagaggaacg tatcaggaga gaaacagagg aaaaagaaga acgccgtagg acagaggatg     2580

agcagaaaga gaaagaaaga gatcgtagga gacatagaga gatgagcaag ctattggcca     2640

ctgtcgttag tggacagaaa caggatagac agggaggaga acgaaggagg tcccaactcg     2700

atcgcgacca gtgtgcctac tgcaaagaaa aggggcactg ggctaaagat tgtcccaaga     2760

aaccacgagg acctcgggga ccaagacccc agacctccct cctgacccta gatgactagg     2820

gaggtcaggg tcaggagccc ccccctgaac ccaggataac cctcaaagtc ggggggcaac     2880

ccgtcacctt cctggtagat actggggccc aacactccgt gctgacccaa aatcctggac     2940

ccctaagtga taagtctgcc tgggtccaag gggctactgg aggaaagcgg tatcgctgga     3000

ccacggatcg caaagtacat ctagctaccg gtaaggtcac ccactctttc ctccatgtac     3060

cagactgtcc ctatcctctg ttaggaagag atttgctgac taaactaaaa gcccaaatcc     3120

actttgaggg atcaggagcc caggttatgg gaccaatggg gcagcccctg caagtgttga     3180

ccctaaatat agaagatgag catcggctac atgagacctc aaaagagcca gatgtttctc     3240

tagggtccac atggctgtct gattttcctc aggcctgggc ggaaaccggg ggcatgggac     3300

tggcagttcg ccaagctcct ctgatcatac ctctgaaagc aacctctacc cccgtgtcca     3360

taaaacaata ccccatgtca caagaagcca gactggggat caagccccac atacagagac     3420

tgttggacca gggaatactg gtaccctgcc agtccccctg gaacacgccc ctgctacccg     3480

ttaagaaacc agggactaat gattataggc ctgtccagga tctgagagaa gtcaacaagc     3540

gggtggaaga catccacccc accgtgccca acccttacaa cctcttgagc gggctcccac     3600

cgtcccacca gtggtacact gtgcttgatt taaaggatgc ctttttctgc ctgagactcc     3660

accccaccag tcagcctctc ttcgcctttg agtggagaga tccagagatg ggaatctcag     3720

gacaattgac ctggaccaga ctcccacagg gtttcaaaaa cagtcccacc ctgtttgatg     3780

aggcactgca cagagaccta gcagacttcc ggatccagca cccagacttg atcctgctac     3840

agtacgtgga tgacttactg ctggccgcca cttctgagct agactgccaa caaggtactc     3900

gggccctgtt acaaacccta gggaacctcg ggtatcgggc ctcggccaag aaagcccaaa     3960

tttgccagaa acaggtcaag tatctggggt atcttctaaa agagggtcag agatggctga     4020

ctgaggccag aaaagagact gtgatggggc agcctactcc gaagacccct cgacaactaa     4080

gggagttcct agggacggca ggcttctgtc gcctctggat ccctgggttt gcagaaatgg     4140

cagccccctt gtaccctctc accaaaacgg ggactctgtt taattggggc ccagaccaac     4200

aaaaggccta tcaagaaatc aagcaagctc ttctaactgc cccagccctg gggttgccag     4260

atttgactaa gccctttgaa ctctttgtcg acgagaagca gggctacgcc aaaggtgtcc     4320

taacgcaaaa actgggacct tggcgtcggc cggtggccta cctgtccaaa aagctagacc     4380

cagtagcagc tgggtggccc ccttgcctac ggatggtagc agccattgcc gtactgacaa     4440

aggatgcagg caagctaacc atgggacagc cactagtcat tctggccccc catgcagtag     4500

aggcactagt caaacaaccc cccgaccgct ggctttccaa cgcccggatg actcactatc     4560

aggccttgct tttggacacg gaccgggtcc agttcggacc ggtggtagcc ctgaacccgg     4620

ctacgctgct cccactgcct gaggaagggc tgcaacacaa ctgccttgat atcctggccg     4680

aagcccacgg aacccgaccc gacctaacgg accagccgct cccagacgcc gaccacacct     4740

ggtacacgga tggaagcagt ctcttacaag agggacagcg taaggcggga gctgcggtga     4800

ccaccgagac cgaggtaatc tgggctaaag ccctgccagc cgggacatcc gctcagcggg     4860

ctgaactgat agcactcacc caggccctaa agatggcaga aggtaagaag ctaaatgttt     4920

atactgatag ccgttatgct tttgctactg cccatatcca tggagaaata tacagaaggc     4980

gtgggttgct cacatcagaa ggcaaagaga tcaaaaataa agacgagatc ttggccctac     5040

taaaagccct ctttctgccc aaaagactta gcataatcca ttgtccagga catcaaaagg     5100

gacacagcgc cgaggctaga ggcaaccgga tggctgacca agcggcccga aaggcagcca     5160

tcacagagac tccagacacc tctaccctcc tcatagaaaa ttcatcaccc tacacctcag     5220

aacattttca ttacacagtg actgatataa aggacctaac caagttgggg gccatttatg     5280

ataaaacaaa gaagtattgg gtctaccaag gaaaacctgt gatgcctgac cagtttactt     5340

ttgaattatt agactttctt catcagctga ctcacctcag cttctcaaaa atgaaggctc     5400

tcctagagag aagccacagt ccctactaca tgctgaaccg ggatcgaaca ctcaaaaata     5460

tcactgagac ctgcaaagct tgtgcacaag tcaacgccag caagtctgcc gttaaacagg     5520

gaactagggt ccgcgggcat cggcccggca ctcattggga gatcgatttc accgagataa     5580

agcccggatt gtatggctat aaatatcttc tagtttttat agataccttt tctggctgga     5640

tagaagcctt cccaaccaag aaagaaaccg ccaaggtcgt aaccaagaag ctactagagg     5700

agatcttccc caggttcggc atgcctcagg tattgggaac tgacaatggg cctgccttcg     5760

tctccaaggt gagtcagaca gtggccgatc tgttggggat tgattggaaa ttacattgtg     5820

catacagacc ccaaagctca ggccaggtag aaagaatgaa tagaaccatc aaggagactt     5880

taactaaatt aacgcttgca actggctcta gagactgggt gctcctactc cccttagccc     5940

tgtaccgagc ccgcaacacg ccgggccccc atggcctcac cccatatgag atcttatatg     6000

gggcaccccc gccccttgta aacttccctg accctgacat gacaagagtt actaacagcc     6060

cctctctcca agctcactta caggctctct acttagtcca gcacgaagtc tggagacctc     6120

tggcggcagc ctaccaagaa caactggacc gaccggtggt acctcaccct taccgagtcg     6180

gcgacacagt gtgggtccgc cgacaccaga ctaagaacct agaacctcgc tggaaaggac     6240

cttacacagt cctgctgacc acccccaccg ccctcaaagt agacggcatc gcagcttgga     6300

tacacgccgc ccacgtgaag gctgccgacc ccgggggtgg accatcctct agactgacat     6360

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat     6420

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt     6480

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg     6540

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga     6600

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag     6660

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg     6720

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta     6780

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga     6840

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc     6900

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc     6960

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg     7020

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt     7080

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat     7140

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag     7200

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga     7260

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa     7320

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt     7380

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca     7440

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac     7500

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc     7560

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt     7620

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca     7680

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt     7740

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat     7800

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat     7860

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc     7920

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg     7980

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt     8040

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac     8100

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc     8160

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct     8220

caatcgattg gtccaatttg ttaaagacag gatctcagtg gtccaggctc tggttttgac     8280

tcagcaatat caccagctaa aacccataga gtacgagcca tgaacgcgtt actggccgaa     8340

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt     8400

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     8460

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     8520

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     8580

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     8640

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     8700

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     8760

gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac     8820

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga ttataaatgg     8880

tgaccggcgg catggcctcc aagtgggatc aaaagggcat ggatatcgct tacgaggagg     8940

ccctgctggg ctacaaggag ggcggcgtgc ctatcggcgg ctgtctgatc aacaacaagg     9000

acggcagtgt gctgggcagg ggccacaaca tgaggttcca gaagggctcc gccaccctgc     9060

acggcgagat ctccaccctg gagaactgtg gcaggctgga gggcaaggtg tacaaggaca     9120

ccaccctgta caccaccctg tccccttgtg acatgtgtac cggcgctatc atcatgtacg     9180

gcatccctag gtgtgtgatc ggcgagaacg tgaacttcaa gtccaagggc gagaagtacc     9240

tgcaaaccag gggccacgag gtggtggttg ttgacgatga gaggtgtaag aagctgatga     9300

agcagttcat cgacgagagg cctcaggact ggttcgagga tatcggcgag taagcggccg     9360

cagataaaat aaaagatttt atttagtctc cagaaaaagg ggggaatgaa agaccccacc     9420

tgtaggtttg gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa     9480

ctgagaatag agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca     9540

aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca     9600

gctgaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca     9660

agaacagatg gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg     9720

tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag     9780

ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa     9840

cccctcactc ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca     9900

ataaaccctc ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct     9960

ctgagtgatt gactacccgt cagcgggggt ctttcattac atgtgagcaa aaggccagca    10020

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc    10080

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata    10140

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc    10200

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc    10260

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga    10320

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc    10380

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag    10440

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag    10500

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag    10560

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca    10620

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    10680

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat    10740

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga    10800

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg    10860

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga    10920

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc    10980

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac    11040

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc    11100

agttaatagt ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc    11160

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc    11220

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt    11280

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc    11340

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg    11400

tatgcggcga ccgagttgct cttgcccggc gtcaacacgg gataataccg cgccacatag    11460

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat    11520

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc    11580

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa    11640

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta    11700

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa    11760

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga    11820

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct    11880

tcaagaattc at                                                        11892


<210>  20
<211>  11892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RCR Vector - pAC3-yCD

<400>  20
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cggcgccagt cctccgattg      600

actgagtcgc ccgggtaccc gtgtatccaa taaaccctct tgcagttgca tccgacttgt      660

ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccgtc agcgggggtc      720

tttcatttgg gggctcgtcc gggatcggga gacccctgcc cagggaccac cgacccacca      780

ccgggaggta agctggccag caacttatct gtgtctgtcc gattgtctag tgtctatgac      840

tgattttatg cgcctgcgtc ggtactagtt agctaactag ctctgtatct ggcggacccg      900

tggtggaact gacgagttcg gaacacccgg ccgcaaccct gggagacgtc ccagggactt      960

cgggggccgt ttttgtggcc cgacctgagt ccaaaaatcc cgatcgtttt ggactctttg     1020

gtgcaccccc cttagaggag ggatatgtgg ttctggtagg agacgagaac ctaaaacagt     1080

tcccgcctcc gtctgaattt ttgctttcgg tttgggaccg aagccgcgcc gcgcgtcttg     1140

tctgctgcag catcgttctg tgttgtctct gtctgactgt gtttctgtat ttgtctgaga     1200

atatgggcca gactgttacc actcccttaa gtttgacctt aggtcactgg aaagatgtcg     1260

agcggatcgc tcacaaccag tcggtagatg tcaagaagag acgttgggtt accttctgct     1320

ctgcagaatg gccaaccttt aacgtcggat ggccgcgaga cggcaccttt aaccgagacc     1380

tcatcaccca ggttaagatc aaggtctttt cacctggccc gcatggacac ccagaccagg     1440

tcccctacat cgtgacctgg gaagccttgg cttttgaccc ccctccctgg gtcaagccct     1500

ttgtacaccc taagcctccg cctcctcttc ctccatccgc cccgtctctc ccccttgaac     1560

ctcctcgttc gaccccgcct cgatcctccc tttatccagc cctcactcct tctctaggcg     1620

ccaaacctaa acctcaagtt ctttctgaca gtggggggcc gctcatcgac ctacttacag     1680

aagacccccc gccttatagg gacccaagac cacccccttc cgacagggac ggaaatggtg     1740

gagaagcgac ccctgcggga gaggcaccgg acccctcccc aatggcatct cgcctacgtg     1800

ggagacggga gccccctgtg gccgactcca ctacctcgca ggcattcccc ctccgcgcag     1860

gaggaaacgg acagcttcaa tactggccgt tctcctcttc tgacctttac aactggaaaa     1920

ataataaccc ttctttttct gaagatccag gtaaactgac agctctgatc gagtctgttc     1980

tcatcaccca tcagcccacc tgggacgact gtcagcagct gttggggact ctgctgaccg     2040

gagaagaaaa acaacgggtg ctcttagagg ctagaaaggc ggtgcggggc gatgatgggc     2100

gccccactca actgcccaat gaagtcgatg ccgcttttcc cctcgagcgc ccagactggg     2160

attacaccac ccaggcaggt aggaaccacc tagtccacta tcgccagttg ctcctagcgg     2220

gtctccaaaa cgcgggcaga agccccacca atttggccaa ggtaaaagga ataacacaag     2280

ggcccaatga gtctccctcg gccttcctag agagacttaa ggaagcctat cgcaggtaca     2340

ctccttatga ccctgaggac ccagggcaag aaactaatgt gtctatgtct ttcatttggc     2400

agtctgcccc agacattggg agaaagttag agaggttaga agatttaaaa aacaagacgc     2460

ttggagattt ggttagagag gcagaaaaga tctttaataa acgagaaacc ccggaagaaa     2520

gagaggaacg tatcaggaga gaaacagagg aaaaagaaga acgccgtagg acagaggatg     2580

agcagaaaga gaaagaaaga gatcgtagga gacatagaga gatgagcaag ctattggcca     2640

ctgtcgttag tggacagaaa caggatagac agggaggaga acgaaggagg tcccaactcg     2700

atcgcgacca gtgtgcctac tgcaaagaaa aggggcactg ggctaaagat tgtcccaaga     2760

aaccacgagg acctcgggga ccaagacccc agacctccct cctgacccta gatgactagg     2820

gaggtcaggg tcaggagccc ccccctgaac ccaggataac cctcaaagtc ggggggcaac     2880

ccgtcacctt cctggtagat actggggccc aacactccgt gctgacccaa aatcctggac     2940

ccctaagtga taagtctgcc tgggtccaag gggctactgg aggaaagcgg tatcgctgga     3000

ccacggatcg caaagtacat ctagctaccg gtaaggtcac ccactctttc ctccatgtac     3060

cagactgtcc ctatcctctg ttaggaagag atttgctgac taaactaaaa gcccaaatcc     3120

actttgaggg atcaggagcc caggttatgg gaccaatggg gcagcccctg caagtgttga     3180

ccctaaatat agaagatgag catcggctac atgagacctc aaaagagcca gatgtttctc     3240

tagggtccac atggctgtct gattttcctc aggcctgggc ggaaaccggg ggcatgggac     3300

tggcagttcg ccaagctcct ctgatcatac ctctgaaagc aacctctacc cccgtgtcca     3360

taaaacaata ccccatgtca caagaagcca gactggggat caagccccac atacagagac     3420

tgttggacca gggaatactg gtaccctgcc agtccccctg gaacacgccc ctgctacccg     3480

ttaagaaacc agggactaat gattataggc ctgtccagga tctgagagaa gtcaacaagc     3540

gggtggaaga catccacccc accgtgccca acccttacaa cctcttgagc gggctcccac     3600

cgtcccacca gtggtacact gtgcttgatt taaaggatgc ctttttctgc ctgagactcc     3660

accccaccag tcagcctctc ttcgcctttg agtggagaga tccagagatg ggaatctcag     3720

gacaattgac ctggaccaga ctcccacagg gtttcaaaaa cagtcccacc ctgtttgatg     3780

aggcactgca cagagaccta gcagacttcc ggatccagca cccagacttg atcctgctac     3840

agtacgtgga tgacttactg ctggccgcca cttctgagct agactgccaa caaggtactc     3900

gggccctgtt acaaacccta gggaacctcg ggtatcgggc ctcggccaag aaagcccaaa     3960

tttgccagaa acaggtcaag tatctggggt atcttctaaa agagggtcag agatggctga     4020

ctgaggccag aaaagagact gtgatggggc agcctactcc gaagacccct cgacaactaa     4080

gggagttcct agggacggca ggcttctgtc gcctctggat ccctgggttt gcagaaatgg     4140

cagccccctt gtaccctctc accaaaacgg ggactctgtt taattggggc ccagaccaac     4200

aaaaggccta tcaagaaatc aagcaagctc ttctaactgc cccagccctg gggttgccag     4260

atttgactaa gccctttgaa ctctttgtcg acgagaagca gggctacgcc aaaggtgtcc     4320

taacgcaaaa actgggacct tggcgtcggc cggtggccta cctgtccaaa aagctagacc     4380

cagtagcagc tgggtggccc ccttgcctac ggatggtagc agccattgcc gtactgacaa     4440

aggatgcagg caagctaacc atgggacagc cactagtcat tctggccccc catgcagtag     4500

aggcactagt caaacaaccc cccgaccgct ggctttccaa cgcccggatg actcactatc     4560

aggccttgct tttggacacg gaccgggtcc agttcggacc ggtggtagcc ctgaacccgg     4620

ctacgctgct cccactgcct gaggaagggc tgcaacacaa ctgccttgat atcctggccg     4680

aagcccacgg aacccgaccc gacctaacgg accagccgct cccagacgcc gaccacacct     4740

ggtacacgga tggaagcagt ctcttacaag agggacagcg taaggcggga gctgcggtga     4800

ccaccgagac cgaggtaatc tgggctaaag ccctgccagc cgggacatcc gctcagcggg     4860

ctgaactgat agcactcacc caggccctaa agatggcaga aggtaagaag ctaaatgttt     4920

atactgatag ccgttatgct tttgctactg cccatatcca tggagaaata tacagaaggc     4980

gtgggttgct cacatcagaa ggcaaagaga tcaaaaataa agacgagatc ttggccctac     5040

taaaagccct ctttctgccc aaaagactta gcataatcca ttgtccagga catcaaaagg     5100

gacacagcgc cgaggctaga ggcaaccgga tggctgacca agcggcccga aaggcagcca     5160

tcacagagac tccagacacc tctaccctcc tcatagaaaa ttcatcaccc tacacctcag     5220

aacattttca ttacacagtg actgatataa aggacctaac caagttgggg gccatttatg     5280

ataaaacaaa gaagtattgg gtctaccaag gaaaacctgt gatgcctgac cagtttactt     5340

ttgaattatt agactttctt catcagctga ctcacctcag cttctcaaaa atgaaggctc     5400

tcctagagag aagccacagt ccctactaca tgctgaaccg ggatcgaaca ctcaaaaata     5460

tcactgagac ctgcaaagct tgtgcacaag tcaacgccag caagtctgcc gttaaacagg     5520

gaactagggt ccgcgggcat cggcccggca ctcattggga gatcgatttc accgagataa     5580

agcccggatt gtatggctat aaatatcttc tagtttttat agataccttt tctggctgga     5640

tagaagcctt cccaaccaag aaagaaaccg ccaaggtcgt aaccaagaag ctactagagg     5700

agatcttccc caggttcggc atgcctcagg tattgggaac tgacaatggg cctgccttcg     5760

tctccaaggt gagtcagaca gtggccgatc tgttggggat tgattggaaa ttacattgtg     5820

catacagacc ccaaagctca ggccaggtag aaagaatgaa tagaaccatc aaggagactt     5880

taactaaatt aacgcttgca actggctcta gagactgggt gctcctactc cccttagccc     5940

tgtaccgagc ccgcaacacg ccgggccccc atggcctcac cccatatgag atcttatatg     6000

gggcaccccc gccccttgta aacttccctg accctgacat gacaagagtt actaacagcc     6060

cctctctcca agctcactta caggctctct acttagtcca gcacgaagtc tggagacctc     6120

tggcggcagc ctaccaagaa caactggacc gaccggtggt acctcaccct taccgagtcg     6180

gcgacacagt gtgggtccgc cgacaccaga ctaagaacct agaacctcgc tggaaaggac     6240

cttacacagt cctgctgacc acccccaccg ccctcaaagt agacggcatc gcagcttgga     6300

tacacgccgc ccacgtgaag gctgccgacc ccgggggtgg accatcctct agactgacat     6360

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat     6420

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt     6480

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg     6540

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga     6600

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag     6660

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg     6720

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta     6780

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga     6840

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc     6900

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc     6960

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg     7020

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt     7080

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat     7140

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag     7200

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga     7260

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa     7320

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt     7380

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca     7440

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac     7500

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc     7560

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt     7620

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca     7680

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt     7740

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat     7800

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat     7860

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc     7920

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg     7980

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt     8040

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac     8100

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc     8160

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct     8220

caatcgattg gtccaatttg ttaaagacag gatctcagtg gtccaggctc tggttttgac     8280

tcagcaatat caccagctaa aacccataga gtacgagcca tgaacgcgtt actggccgaa     8340

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt     8400

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     8460

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     8520

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     8580

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     8640

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     8700

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     8760

gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac     8820

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga ttataaatgg     8880

tgacaggggg aatggcaagc aagtgggatc agaagggtat ggacattgcc tatgaggagg     8940

cggccttagg ttacaaagag ggtggtgttc ctattggcgg atgtcttatc aataacaaag     9000

acggaagtgt tctcggtcgt ggtcacaaca tgagatttca aaagggatcc gccacactac     9060

atggtgagat ctccactttg gaaaactgtg ggagattaga gggcaaagtg tacaaagata     9120

ccactttgta tacgacgctg tctccatgcg acatgtgtac aggtgccatc atcatgtatg     9180

gtattccacg ctgtgttgtc ggtgagaacg ttaatttcaa aagtaagggc gagaaatatt     9240

tacaaactag aggtcacgag gttgttgttg ttgacgatga gaggtgtaaa aagatcatga     9300

aacaatttat cgatgaaaga cctcaggatt ggtttgaaga tattggtgag taggcggccg     9360

cagataaaat aaaagatttt atttagtctc cagaaaaagg ggggaatgaa agaccccacc     9420

tgtaggtttg gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa     9480

ctgagaatag agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca     9540

aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca     9600

gctgaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca     9660

agaacagatg gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg     9720

tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag     9780

ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa     9840

cccctcactc ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca     9900

ataaaccctc ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct     9960

ctgagtgatt gactacccgt cagcgggggt ctttcattac atgtgagcaa aaggccagca    10020

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc    10080

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata    10140

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc    10200

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc    10260

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga    10320

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc    10380

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag    10440

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag    10500

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag    10560

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca    10620

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    10680

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat    10740

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga    10800

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg    10860

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga    10920

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc    10980

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac    11040

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc    11100

agttaatagt ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc    11160

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc    11220

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt    11280

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc    11340

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg    11400

tatgcggcga ccgagttgct cttgcccggc gtcaacacgg gataataccg cgccacatag    11460

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat    11520

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc    11580

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa    11640

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta    11700

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa    11760

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga    11820

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct    11880

tcaagaattc at                                                        11892


<210>  21
<211>  12007
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RCR Vector - pACE-CD

<400>  21
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cggcgccagt cctccgattg      600

actgagtcgc ccgggtaccc gtgtatccaa taaaccctct tgcagttgca tccgacttgt      660

ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccgtc agcgggggtc      720

tttcatttgg gggctcgtcc gggatcggga gacccctgcc cagggaccac cgacccacca      780

ccgggaggta agctggccag caacttatct gtgtctgtcc gattgtctag tgtctatgac      840

tgattttatg cgcctgcgtc ggtactagtt agctaactag ctctgtatct ggcggacccg      900

tggtggaact gacgagttcg gaacacccgg ccgcaaccct gggagacgtc ccagggactt      960

cgggggccgt ttttgtggcc cgacctgagt ccaaaaatcc cgatcgtttt ggactctttg     1020

gtgcaccccc cttagaggag ggatatgtgg ttctggtagg agacgagaac ctaaaacagt     1080

tcccgcctcc gtctgaattt ttgctttcgg tttgggaccg aagccgcgcc gcgcgtcttg     1140

tctgctgcag catcgttctg tgttgtctct gtctgactgt gtttctgtat ttgtctgaga     1200

atatgggcca gactgttacc actcccttaa gtttgacctt aggtcactgg aaagatgtcg     1260

agcggatcgc tcacaaccag tcggtagatg tcaagaagag acgttgggtt accttctgct     1320

ctgcagaatg gccaaccttt aacgtcggat ggccgcgaga cggcaccttt aaccgagacc     1380

tcatcaccca ggttaagatc aaggtctttt cacctggccc gcatggacac ccagaccagg     1440

tcccctacat cgtgacctgg gaagccttgg cttttgaccc ccctccctgg gtcaagccct     1500

ttgtacaccc taagcctccg cctcctcttc ctccatccgc cccgtctctc ccccttgaac     1560

ctcctcgttc gaccccgcct cgatcctccc tttatccagc cctcactcct tctctaggcg     1620

ccaaacctaa acctcaagtt ctttctgaca gtggggggcc gctcatcgac ctacttacag     1680

aagacccccc gccttatagg gacccaagac cacccccttc cgacagggac ggaaatggtg     1740

gagaagcgac ccctgcggga gaggcaccgg acccctcccc aatggcatct cgcctacgtg     1800

ggagacggga gccccctgtg gccgactcca ctacctcgca ggcattcccc ctccgcgcag     1860

gaggaaacgg acagcttcaa tactggccgt tctcctcttc tgacctttac aactggaaaa     1920

ataataaccc ttctttttct gaagatccag gtaaactgac agctctgatc gagtctgttc     1980

tcatcaccca tcagcccacc tgggacgact gtcagcagct gttggggact ctgctgaccg     2040

gagaagaaaa acaacgggtg ctcttagagg ctagaaaggc ggtgcggggc gatgatgggc     2100

gccccactca actgcccaat gaagtcgatg ccgcttttcc cctcgagcgc ccagactggg     2160

attacaccac ccaggcaggt aggaaccacc tagtccacta tcgccagttg ctcctagcgg     2220

gtctccaaaa cgcgggcaga agccccacca atttggccaa ggtaaaagga ataacacaag     2280

ggcccaatga gtctccctcg gccttcctag agagacttaa ggaagcctat cgcaggtaca     2340

ctccttatga ccctgaggac ccagggcaag aaactaatgt gtctatgtct ttcatttggc     2400

agtctgcccc agacattggg agaaagttag agaggttaga agatttaaaa aacaagacgc     2460

ttggagattt ggttagagag gcagaaaaga tctttaataa acgagaaacc ccggaagaaa     2520

gagaggaacg tatcaggaga gaaacagagg aaaaagaaga acgccgtagg acagaggatg     2580

agcagaaaga gaaagaaaga gatcgtagga gacatagaga gatgagcaag ctattggcca     2640

ctgtcgttag tggacagaaa caggatagac agggaggaga acgaaggagg tcccaactcg     2700

atcgcgacca gtgtgcctac tgcaaagaaa aggggcactg ggctaaagat tgtcccaaga     2760

aaccacgagg acctcgggga ccaagacccc agacctccct cctgacccta gatgactagg     2820

gaggtcaggg tcaggagccc ccccctgaac ccaggataac cctcaaagtc ggggggcaac     2880

ccgtcacctt cctggtagat actggggccc aacactccgt gctgacccaa aatcctggac     2940

ccctaagtga taagtctgcc tgggtccaag gggctactgg aggaaagcgg tatcgctgga     3000

ccacggatcg caaagtacat ctagctaccg gtaaggtcac ccactctttc ctccatgtac     3060

cagactgtcc ctatcctctg ttaggaagag atttgctgac taaactaaaa gcccaaatcc     3120

actttgaggg atcaggagcc caggttatgg gaccaatggg gcagcccctg caagtgttga     3180

ccctaaatat agaagatgag catcggctac atgagacctc aaaagagcca gatgtttctc     3240

tagggtccac atggctgtct gattttcctc aggcctgggc ggaaaccggg ggcatgggac     3300

tggcagttcg ccaagctcct ctgatcatac ctctgaaagc aacctctacc cccgtgtcca     3360

taaaacaata ccccatgtca caagaagcca gactggggat caagccccac atacagagac     3420

tgttggacca gggaatactg gtaccctgcc agtccccctg gaacacgccc ctgctacccg     3480

ttaagaaacc agggactaat gattataggc ctgtccagga tctgagagaa gtcaacaagc     3540

gggtggaaga catccacccc accgtgccca acccttacaa cctcttgagc gggctcccac     3600

cgtcccacca gtggtacact gtgcttgatt taaaggatgc ctttttctgc ctgagactcc     3660

accccaccag tcagcctctc ttcgcctttg agtggagaga tccagagatg ggaatctcag     3720

gacaattgac ctggaccaga ctcccacagg gtttcaaaaa cagtcccacc ctgtttgatg     3780

aggcactgca cagagaccta gcagacttcc ggatccagca cccagacttg atcctgctac     3840

agtacgtgga tgacttactg ctggccgcca cttctgagct agactgccaa caaggtactc     3900

gggccctgtt acaaacccta gggaacctcg ggtatcgggc ctcggccaag aaagcccaaa     3960

tttgccagaa acaggtcaag tatctggggt atcttctaaa agagggtcag agatggctga     4020

ctgaggccag aaaagagact gtgatggggc agcctactcc gaagacccct cgacaactaa     4080

gggagttcct agggacggca ggcttctgtc gcctctggat ccctgggttt gcagaaatgg     4140

cagccccctt gtaccctctc accaaaacgg ggactctgtt taattggggc ccagaccaac     4200

aaaaggccta tcaagaaatc aagcaagctc ttctaactgc cccagccctg gggttgccag     4260

atttgactaa gccctttgaa ctctttgtcg acgagaagca gggctacgcc aaaggtgtcc     4320

taacgcaaaa actgggacct tggcgtcggc cggtggccta cctgtccaaa aagctagacc     4380

cagtagcagc tgggtggccc ccttgcctac ggatggtagc agccattgcc gtactgacaa     4440

aggatgcagg caagctaacc atgggacagc cactagtcat tctggccccc catgcagtag     4500

aggcactagt caaacaaccc cccgaccgct ggctttccaa cgcccggatg actcactatc     4560

aggccttgct tttggacacg gaccgggtcc agttcggacc ggtggtagcc ctgaacccgg     4620

ctacgctgct cccactgcct gaggaagggc tgcaacacaa ctgccttgat atcctggccg     4680

aagcccacgg aacccgaccc gacctaacgg accagccgct cccagacgcc gaccacacct     4740

ggtacacgga tggaagcagt ctcttacaag agggacagcg taaggcggga gctgcggtga     4800

ccaccgagac cgaggtaatc tgggctaaag ccctgccagc cgggacatcc gctcagcggg     4860

ctgaactgat agcactcacc caggccctaa agatggcaga aggtaagaag ctaaatgttt     4920

atactgatag ccgttatgct tttgctactg cccatatcca tggagaaata tacagaaggc     4980

gtgggttgct cacatcagaa ggcaaagaga tcaaaaataa agacgagatc ttggccctac     5040

taaaagccct ctttctgccc aaaagactta gcataatcca ttgtccagga catcaaaagg     5100

gacacagcgc cgaggctaga ggcaaccgga tggctgacca agcggcccga aaggcagcca     5160

tcacagagac tccagacacc tctaccctcc tcatagaaaa ttcatcaccc tacacctcag     5220

aacattttca ttacacagtg actgatataa aggacctaac caagttgggg gccatttatg     5280

ataaaacaaa gaagtattgg gtctaccaag gaaaacctgt gatgcctgac cagtttactt     5340

ttgaattatt agactttctt catcagctga ctcacctcag cttctcaaaa atgaaggctc     5400

tcctagagag aagccacagt ccctactaca tgctgaaccg ggatcgaaca ctcaaaaata     5460

tcactgagac ctgcaaagct tgtgcacaag tcaacgccag caagtctgcc gttaaacagg     5520

gaactagggt ccgcgggcat cggcccggca ctcattggga gatcgatttc accgagataa     5580

agcccggatt gtatggctat aaatatcttc tagtttttat agataccttt tctggctgga     5640

tagaagcctt cccaaccaag aaagaaaccg ccaaggtcgt aaccaagaag ctactagagg     5700

agatcttccc caggttcggc atgcctcagg tattgggaac tgacaatggg cctgccttcg     5760

tctccaaggt gagtcagaca gtggccgatc tgttggggat tgattggaaa ttacattgtg     5820

catacagacc ccaaagctca ggccaggtag aaagaatgaa tagaaccatc aaggagactt     5880

taactaaatt aacgcttgca actggctcta gagactgggt gctcctactc cccttagccc     5940

tgtaccgagc ccgcaacacg ccgggccccc atggcctcac cccatatgag atcttatatg     6000

gggcaccccc gccccttgta aacttccctg accctgacat gacaagagtt actaacagcc     6060

cctctctcca agctcactta caggctctct acttagtcca gcacgaagtc tggagacctc     6120

tggcggcagc ctaccaagaa caactggacc gaccggtggt acctcaccct taccgagtcg     6180

gcgacacagt gtgggtccgc cgacaccaga ctaagaacct agaacctcgc tggaaaggac     6240

cttacacagt cctgctgacc acccccaccg ccctcaaagt agacggcatc gcagcttgga     6300

tacacgccgc ccacgtgaag gctgccgacc ccgggggtgg accatcctct agactgacat     6360

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat     6420

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt     6480

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg     6540

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga     6600

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag     6660

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg     6720

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta     6780

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga     6840

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc     6900

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc     6960

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg     7020

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt     7080

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat     7140

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag     7200

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga     7260

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa     7320

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt     7380

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca     7440

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac     7500

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc     7560

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt     7620

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca     7680

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt     7740

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat     7800

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat     7860

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc     7920

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg     7980

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt     8040

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac     8100

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc     8160

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct     8220

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac     8280

tcaacaatat caccagctga agcctataga gtacgagcca tgacgtacgt tactggccga     8340

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     8400

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     8460

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     8520

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     8580

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     8640

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     8700

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     8760

ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa     8820

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat     8880

ggtgacaggg ggaatggcaa gcaagtggga tcagaagggt atggacattg cctatgagga     8940

ggcggcctta ggttacaaag agggtggtgt tcctattggc ggatgtctta tcaataacaa     9000

agacggaagt gttctcggtc gtggtcacaa catgagattt caaaagggat ccgccacact     9060

acatggtgag atctccactt tggaaaactg tgggagatta gagggcaaag tgtacaaaga     9120

taccactttg tatacgacgc tgtctccatg cgacatgtgt acaggtgcca tcatcatgta     9180

tggtattcca cgctgtgttg tcggtgagaa cgttaatttc aaaagtaagg gcgagaaata     9240

tttacaaact agaggtcacg aggttgttgt tgttgacgat gagaggtgta aaaagatcat     9300

gaaacaattt atcgatgaaa gacctcagga ttggtttgaa gatattggtg agtaggcggc     9360

cgcgccatag ataaaataaa agattttatt tagtctccag aaaaaggggg gaatgaaaga     9420

ccccacctgt aggtttggca agctagctta agtaacgcca ttttgcaagg catggaaaaa     9480

tacataactg agaatagaga agttcagatc aaggtcagga acagatggaa cagctgaata     9540

tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga     9600

tggaacagct gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc     9660

agggccaaga acagatggtc cccagatgcg gtccagccct cagcagtttc tagagaacca     9720

tcagatgttt ccagggtgcc ccaaggacct gaaatgaccc tgtgccttgt ttaaactaac     9780

caatcagttc gcttctcgct tctgttcgcg cgcttctgct ccccgagctc aataaaagag     9840

cccacaaccc ctcactcggg gcgccagtcc tccgattgac tgagtcgccc gggtacccgt     9900

gtatccaata aaccctcttg cagttgcatc cgacttgtgg tctcgctgtt ccttgggagg     9960

gtctcctctg agtgattgac tacccgtcag cgggggtctt tcatttgggg gctcgtccgg    10020

gatcgggaga cccctgccca gggaccaccg acccaccacc gggaggtaag ctggctgcct    10080

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacatgtg agcaaaaggc cagcaaaagg    10140

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg    10200

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat    10260

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta    10320

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct    10380

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc    10440

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa    10500

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg    10560

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag    10620

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt    10680

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta    10740

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc    10800

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca    10860

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa    10920

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat    10980

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct    11040

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt    11100

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat    11160

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta    11220

atagtttgcg caacgttgtt gccattgctg caggcatcgt ggtgtcacgc tcgtcgtttg    11280

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt    11340

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg    11400

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg    11460

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc    11520

ggcgaccgag ttgctcttgc ccggcgtcaa cacgggataa taccgcgcca catagcagaa    11580

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac    11640

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt    11700

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg    11760

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa    11820

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata    11880

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca    11940

ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtcttcaag    12000

aattcat                                                              12007


<210>  22
<211>  11893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RCR Vector - pAC3-yCD2

<400>  22
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cggcgccagt cctccgattg      600

actgagtcgc ccgggtaccc gtgtatccaa taaaccctct tgcagttgca tccgacttgt      660

ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccgtc agcgggggtc      720

tttcatttgg gggctcgtcc gggatcggga gacccctgcc cagggaccac cgacccacca      780

ccgggaggta agctggccag caacttatct gtgtctgtcc gattgtctag tgtctatgac      840

tgattttatg cgcctgcgtc ggtactagtt agctaactag ctctgtatct ggcggacccg      900

tggtggaact gacgagttcg gaacacccgg ccgcaaccct gggagacgtc ccagggactt      960

cgggggccgt ttttgtggcc cgacctgagt ccaaaaatcc cgatcgtttt ggactctttg     1020

gtgcaccccc cttagaggag ggatatgtgg ttctggtagg agacgagaac ctaaaacagt     1080

tcccgcctcc gtctgaattt ttgctttcgg tttgggaccg aagccgcgcc gcgcgtcttg     1140

tctgctgcag catcgttctg tgttgtctct gtctgactgt gtttctgtat ttgtctgaaa     1200

atatgggcca gactgttacc actcccttaa gtttgacctt aggtcactgg aaagatgtcg     1260

agcggatcgc tcacaaccag tcggtagatg tcaagaagag acgttgggtt accttctgct     1320

ctgcagaatg gccaaccttt aacgtcggat ggccgcgaga cggcaccttt aaccgagacc     1380

tcatcaccca ggttaagatc aaggtctttt cacctggccc gcatggacac ccagaccagg     1440

tcccctacat cgtgacctgg gaagccttgg cttttgaccc ccctccctgg gtcaagccct     1500

ttgtacaccc taagcctccg cctcctcttc ctccatccgc cccgtctctc ccccttgaac     1560

ctcctcgttc gaccccgcct cgatcctccc tttatccagc cctcactcct tctctaggcg     1620

ccaaacctaa acctcaagtt ctttctgaca gtggggggcc gctcatcgac ctacttacag     1680

aagacccccc gccttatagg gacccaagac cacccccttc cgacagggac ggaaatggtg     1740

gagaagcgac ccctgcggga gaggcaccgg acccctcccc aatggcatct cgcctacgtg     1800

ggagacggga gccccctgtg gccgactcca ctacctcgca ggcattcccc ctccgcgcag     1860

gaggaaacgg acagcttcaa tactggccgt tctcctcttc tgacctttac aactggaaaa     1920

ataataaccc ttctttttct gaagatccag gtaaactgac agctctgatc gagtctgtcc     1980

tcatcaccca tcagcccacc tgggacgact gtcagcagct gttggggact ctgctgaccg     2040

gagaagaaaa acaacgggtg ctcttagagg ctagaaaggc ggtgcggggc gatgatgggc     2100

gccccactca actgcccaat gaagtcgatg ccgcttttcc cctcgagcgc ccagactggg     2160

attacaccac ccaggcaggt aggaaccacc tagtccacta tcgccagttg ctcctagcgg     2220

gtctccaaaa cgcgggcaga agccccacca atttggccaa ggtaaaagga ataacacaag     2280

ggcccaatga gtctccctcg gccttcctag agagacttaa ggaagcctat cgcaggtaca     2340

ctccttatga ccctgaggac ccagggcaag aaactaatgt gtctatgtct ttcatttggc     2400

agtctgcccc agacattggg agaaagttag agaggttaga agatttaaaa aacaagacgc     2460

ttggagattt ggttagagag gcagaaaaga tctttaataa acgagaaacc ccggaagaaa     2520

gagaggaacg tatcaggaga gaaacagagg aaaaagaaga acgccgtagg acagaggatg     2580

agcagaaaga gaaagaaaga gatcgtagga gacatagaga gatgagcaag ctattggcca     2640

ctgtcgttag tggacagaaa caggatagac agggaggaga acgaaggagg tcccaactcg     2700

atcgcgacca gtgtgcctac tgcaaagaaa aggggcactg ggctaaagat tgtcccaaga     2760

aaccacgagg acctcgggga ccaagacccc agacctccct cctgacccta gatgactagg     2820

gaggtcaggg tcaggagccc ccccctgaac ccaggataac cctcaaagtc ggggggcaac     2880

ccgtcacctt cctggtagat actggggccc aacactccgt gctgacccaa aatcctggac     2940

ccctaagtga taagtctgcc tgggtccaag gggctactgg aggaaagcgg tatcgctgga     3000

ccacggatcg caaagtacat ctagctaccg gtaaggtcac ccactctttc ctccatgtac     3060

cagactgtcc ctatcctctg ttaggaagag atttgctgac taaactaaaa gcccaaatcc     3120

actttgaggg atcaggagcc caggttatgg gaccaatggg gcagcccctg caagtgttga     3180

ccctaaatat agaagatgag tatcggctac atgagacctc aaaagagcca gatgtttctc     3240

tagggtccac atggctgtct gattttcctc aggcctgggc ggaaaccggg ggcatgggac     3300

tggcagttcg ccaagctcct ctgatcatac ctctgaaagc aacctctacc cccgtgtcca     3360

taaaacaata ccccatgtca caagaagcca gactggggat caagccccac atacagagac     3420

tgttggacca gggaatactg gtaccctgcc agtccccctg gaacacgccc ctgctacccg     3480

ttaagaaacc agggactaat gattataggc ctgtccagga tctgagagaa gtcaacaagc     3540

gggtggaaga catccacccc accgtgccca acccttacaa cctcttgagc gggctcccac     3600

cgtcccacca gtggtacact gtgcttgatt taaaggatgc ctttttctgc ctgagactcc     3660

accccaccag tcagcctctc ttcgcctttg agtggagaga tccagagatg ggaatctcag     3720

gacaattgac ctggaccaga ctcccacagg gtttcaaaaa cagtcccacc ctgtttgatg     3780

aggcactgca cagagaccta gcagacttcc ggatccagca cccagacttg atcctgctac     3840

agtacgtgga tgacttactg ctggccgcca cttctgagct agactgccaa caaggtactc     3900

gggccctgtt acaaacccta gggaacctcg ggtatcgggc ctcggccaag aaagcccaaa     3960

tttgccagaa acaggtcaag tatctggggt atcttctaaa agagggtcag agatggctga     4020

ctgaggccag aaaagagact gtgatggggc agcctactcc gaagacccct cgacaactaa     4080

gggagttcct agggacggca ggcttctgtc gcctctggat ccctgggttt gcagaaatgg     4140

cagccccctt gtaccctctc accaaaacgg ggactctgtt taattggggc ccagaccaac     4200

aaaaggccta tcaagaaatc aagcaagctc ttctaactgc cccagccctg gggttgccag     4260

atttgactaa gccctttgaa ctctttgtcg acgagaagca gggctacgcc aaaggtgtcc     4320

taacgcaaaa actgggacct tggcgtcggc cggtggccta cctgtccaaa aagctagacc     4380

cagtagcagc tgggtggccc ccttgcctac ggatggtagc agccattgcc gtactgacaa     4440

aggatgcagg caagctaacc atgggacagc cactagtcat tctggccccc catgcagtag     4500

aggcactagt caaacaaccc cccgaccgct ggctttccaa cgcccggatg actcactatc     4560

aggccttgct tttggacacg gaccgggtcc agttcggacc ggtggtagcc ctgaacccgg     4620

ctacgctgct cccactgcct gaggaagggc tgcaacacaa ctgccttgat atcctggccg     4680

aagcccacgg aacccgaccc gacctaacgg accagccgct cccagacgcc gaccacacct     4740

ggtacacgga tggaagcagt ctcttacaag agggacagcg taaggcggga gctgcggtga     4800

ccaccgagac cgaggtaatc tgggctaaag ccctgccagc cgggacatcc gctcagcggg     4860

ctgaactgat agcactcacc caggccctaa agatggcaga aggtaagaag ctaaatgttt     4920

atactgatag ccgttatgct tttgctactg cccatatcca tggagaaata tacagaaggc     4980

gtgggttgct cacatcagaa ggcaaagaga tcaaaaataa agacgagatc ttggccctac     5040

taaaagccct ctttctgccc aaaagactta gcataatcca ttgtccagga catcaaaagg     5100

gacacagcgc cgaggctaga ggcaaccgga tggctgacca agcggcccga aaggcagcca     5160

tcacagagac tccagacacc tctaccctcc tcatagaaaa ttcatcaccc tacacctcag     5220

aacattttca ttacacagtg actgatataa aggacctaac caagttgggg gccatttatg     5280

ataaaacaaa gaagtattgg gtctaccaag gaaaacctgt gatgcctgac cagtttactt     5340

ttgaattatt agactttctt catcagctga ctcacctcag cttctcaaaa atgaaggctc     5400

tcctagagag aagccacagt ccctactaca tgctgaaccg ggatcgaaca ctcaaaaata     5460

tcactgagac ctgcaaagct tgtgcacaag tcaacgccag caagtctgcc gttaaacagg     5520

gaactagggt ccgcgggcat cggcccggca ctcattggga gatcgatttc accgagataa     5580

agcccggatt gtatggctat aaatatcttc tagtttttat agataccttt tctggctgga     5640

tagaagcctt cccaaccaag aaagaaaccg ccaaggtcgt aaccaagaag ctactagagg     5700

agatcttccc caggttcggc atgcctcagg tattgggaac tgacaatggg cctgccttcg     5760

tctccaaggt gagtcagaca gtggccgatc tgttggggat tgattggaaa ttacattgtg     5820

catacagacc ccaaagctca ggccaggtag aaagaatgaa tagaaccatc aaggagactt     5880

taactaaatt aacgcttgca actggctcta gagactgggt gctcctactc cccttagccc     5940

tgtaccgagc ccgcaacacg ccgggccccc atggcctcac cccatatgag atcttatatg     6000

gggcaccccc gccccttgta aacttccctg accctgacat gacaagagtt actaacagcc     6060

cctctctcca agctcactta caggctctct acttagtcca gcacgaagtc tggagacctc     6120

tggcggcagc ctaccaagaa caactggacc gaccggtggt acctcaccct taccgagtcg     6180

gcgacacagt gtgggtccgc cgacaccaga ctaagaacct agaacctcgc tggaaaggac     6240

cttacacagt cctgctgacc acccccaccg ccctcaaagt agacggcatc gcagcttgga     6300

tacacgccgc ccacgtgaag gctgccgacc ccgggggtgg accatcctct agactgacat     6360

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat     6420

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt     6480

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg     6540

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga     6600

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag     6660

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg     6720

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta     6780

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga     6840

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc     6900

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc     6960

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg     7020

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt     7080

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat     7140

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag     7200

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga     7260

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa     7320

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt     7380

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca     7440

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac     7500

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc     7560

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt     7620

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca     7680

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt     7740

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat     7800

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat     7860

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc     7920

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg     7980

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt     8040

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac     8100

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc     8160

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct     8220

caatcgattg gtccaatttg ttaaagacag gatctcagtg gtccaggctc tggttttgac     8280

tcagcaatat caccagctaa aacccataga gtacgagcca tgaacgcgtt actggccgaa     8340

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt     8400

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     8460

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     8520

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     8580

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     8640

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     8700

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     8760

gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac     8820

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga ttataaatgg     8880

tgaccggcgg catggcctcc aagtgggatc aaaagggcat ggatatcgct tacgaggagg     8940

ccctgctggg ctacaaggag ggcggcgtgc ctatcggcgg ctgtctgatc aacaacaagg     9000

acggcagtgt gctgggcagg ggccacaaca tgaggttcca gaagggctcc gccaccctgc     9060

acggcgagat ctccaccctg gagaactgtg gcaggctgga gggcaaggtg tacaaggaca     9120

ccaccctgta caccaccctg tccccttgtg acatgtgtac cggcgctatc atcatgtacg     9180

gcatccctag gtgtgtgatc ggcgagaacg tgaacttcaa gtccaagggc gagaagtacc     9240

tgcaaaccag gggccacgag gtggtggttg ttgacgatga gaggtgtaag aagctgatga     9300

agcagttcat cgacgagagg cctcaggact ggttcgagga tatcggcgag taagcggccg     9360

cagataaaat aaaagatttt atttagtctc cagaaaaagg ggggaatgaa agaccccacc     9420

tgtaggtttg gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa     9480

ctgagaatag agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca     9540

aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca     9600

gctgaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca     9660

agaacagatg gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg     9720

tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag     9780

ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa     9840

cccctcactc ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca     9900

ataaaccctc ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct     9960

ctgagtgatt gactacccgt cagcgggggt ctttcattac atgtgagcaa aaggccagca    10020

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc    10080

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata    10140

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc    10200

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc    10260

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga    10320

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc    10380

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag    10440

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag    10500

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag    10560

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca    10620

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    10680

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat    10740

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga    10800

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg    10860

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga    10920

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc    10980

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac    11040

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc    11100

agttaatagt ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt cacgctcgtc    11160

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc    11220

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt    11280

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc    11340

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg    11400

tatgcggcga ccgagttgct cttgcccggc gtcaacacgg gataataccg cgccacatag    11460

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat    11520

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc    11580

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa    11640

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta    11700

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa    11760

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga    11820

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct    11880

tcaagaattc cat                                                       11893


<210>  23
<211>  4473
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (175)..(3942)

<400>  23
aaggggaggt aaccctggcc cctttggtcg gggccccggg cagccgcgcg ccccttccca       60

cggggccctt tactgcgccg cgcgcccggc ccccacccct cgcagcaccc cgcgccccgc      120

gccctcccag ccgggtccag ccggagccat ggggccggag ccgcagtgag cacc atg        177
                                                            Met           
                                                            1             

gag ctg gcg gcc ttg tgc cgc tgg ggg ctc ctc ctc gcc ctc ttg ccc        225
Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu Pro           
            5                   10                  15                    

ccc gga gcc gcg agc acc caa gtg tgc acc ggc aca gac atg aag ctg        273
Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu           
        20                  25                  30                        

cgg ctc cct gcc agt ccc gag acc cac ctg gac atg ctc cgc cac ctc        321
Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His Leu           
    35                  40                  45                            

tac cag ggc tgc cag gtg gtg cag gga aac ctg gaa ctc acc tac ctg        369
Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu           
50                  55                  60                  65            

ccc acc aat gcc agc ctg tcc ttc ctg cag gat atc cag gag gtg cag        417
Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln           
                70                  75                  80                

ggc tac gtg ctc atc gct cac aac caa gtg agg cag gtc cca ctg cag        465
Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln           
            85                  90                  95                    

agg ctg cgg att gtg cga ggc acc cag ctc ttt gag gac aac tat gcc        513
Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala           
        100                 105                 110                       

ctg gcc gtg cta gac aat gga gac ccg ctg aac aat acc acc cct gtc        561
Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val           
    115                 120                 125                           

aca ggg gcc tcc cca gga ggc ctg cgg gag ctg cag ctt cga agc ctc        609
Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu           
130                 135                 140                 145           

aca gag atc ttg aaa gga ggg gtc ttg atc cag cgg aac ccc cag ctc        657
Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu           
                150                 155                 160               

tgc tac cag gac acg att ttg tgg aag gac atc ttc cac aag aac aac        705
Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn           
            165                 170                 175                   

cag ctg gct ctc aca ctg ata gac acc aac cgc tct cgg gcc tgc cac        753
Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His           
        180                 185                 190                       

ccc tgt tct ccg atg tgt aag ggc tcc cgc tgc tgg gga gag agt tct        801
Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser           
    195                 200                 205                           

gag gat tgt cag agc ctg acg cgc act gtc tgt gcc ggt ggc tgt gcc        849
Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala           
210                 215                 220                 225           

cgc tgc aag ggg cca ctg ccc act gac tgc tgc cat gag cag tgt gct        897
Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala           
                230                 235                 240               

gcc ggc tgc acg ggc ccc aag cac tct gac tgc ctg gcc tgc ctc cac        945
Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His           
            245                 250                 255                   

ttc aac cac agt ggc atc tgt gag ctg cac tgc cca gcc ctg gtc acc        993
Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr           
        260                 265                 270                       

tac aac aca gac acg ttt gag tcc atg ccc aat ccc gag ggc cgg tat       1041
Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr           
    275                 280                 285                           

aca ttc ggc gcc agc tgt gtg act gcc tgt ccc tac aac tac ctt tct       1089
Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser           
290                 295                 300                 305           

acg gac gtg gga tcc tgc acc ctc gtc tgc ccc ctg cac aac caa gag       1137
Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu           
                310                 315                 320               

gtg aca gca gag gat gga aca cag cgg tgt gag aag tgc agc aag ccc       1185
Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro           
            325                 330                 335                   

tgt gcc cga gtg tgc tat ggt ctg ggc atg gag cac ttg cga gag gtg       1233
Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val           
        340                 345                 350                       

agg gca gtt acc agt gcc aat atc cag gag ttt gct ggc tgc aag aag       1281
Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys           
    355                 360                 365                           

atc ttt ggg agc ctg gca ttt ctg ccg gag agc ttt gat ggg gac cca       1329
Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro           
370                 375                 380                 385           

gcc tcc aac act gcc ccg ctc cag cca gag cag ctc caa gtg ttt gag       1377
Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu           
                390                 395                 400               

act ctg gaa gag atc aca ggt tac cta tac atc tca gca tgg ccg gac       1425
Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp           
            405                 410                 415                   

agc ctg cct gac ctc agc gtc ttc cag aac ctg caa gta atc cgg gga       1473
Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly           
        420                 425                 430                       

cga att ctg cac aat ggc gcc tac tcg ctg acc ctg caa ggg ctg ggc       1521
Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly           
    435                 440                 445                           

atc agc tgg ctg ggg ctg cgc tca ctg agg gaa ctg ggc agt gga ctg       1569
Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu           
450                 455                 460                 465           

gcc ctc atc cac cat aac acc cac ctc tgc ttc gtg cac acg gtg ccc       1617
Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val Pro           
                470                 475                 480               

tgg gac cag ctc ttt cgg aac ccg cac caa gct ctg ctc cac act gcc       1665
Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala           
            485                 490                 495                   

aac cgg cca gag gac gag tgt gtg ggc gag ggc ctg gcc tgc cac cag       1713
Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln           
        500                 505                 510                       

ctg tgc gcc cga ggg cac tgc tgg ggt cca ggg ccc acc cag tgt gtc       1761
Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val           
    515                 520                 525                           

aac tgc agc cag ttc ctt cgg ggc cag gag tgc gtg gag gaa tgc cga       1809
Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg           
530                 535                 540                 545           

gta ctg cag ggg ctc ccc agg gag tat gtg aat gcc agg cac tgt ttg       1857
Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu           
                550                 555                 560               

ccg tgc cac cct gag tgt cag ccc cag aat ggc tca gtg acc tgt ttt       1905
Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe           
            565                 570                 575                   

gga ccg gag gct gac cag tgt gtg gcc tgt gcc cac tat aag gac cct       1953
Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro           
        580                 585                 590                       

ccc ttc tgc gtg gcc cgc tgc ccc agc ggt gtg aaa cct gac ctc tcc       2001
Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser           
    595                 600                 605                           

tac atg ccc atc tgg aag ttt cca gat gag gag ggc gca tgc cag cct       2049
Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro           
610                 615                 620                 625           

tgc ccc atc aac tgc acc cac tcc tgt gtg gac ctg gat gac aag ggc       2097
Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly           
                630                 635                 640               

tgc ccc gcc gag cag aga gcc agc cct ctg acg tcc atc atc tct gcg       2145
Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala           
            645                 650                 655                   

gtg gtt ggc att ctg ctg gtc gtg gtc ttg ggg gtg gtc ttt ggg atc       2193
Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile           
        660                 665                 670                       

ctc atc aag cga cgg cag cag aag atc cgg aag tac acg atg cgg aga       2241
Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg           
    675                 680                 685                           

ctg ctg cag gaa acg gag ctg gtg gag ccg ctg aca cct agc gga gcg       2289
Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala           
690                 695                 700                 705           

atg ccc aac cag gcg cag atg cgg atc ctg aaa gag acg gag ctg agg       2337
Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg           
                710                 715                 720               

aag gtg aag gtg ctt gga tct ggc gct ttt ggc aca gtc tac aag ggc       2385
Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly           
            725                 730                 735                   

atc tgg atc cct gat ggg gag aat gtg aaa att cca gtg gcc atc aaa       2433
Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys           
        740                 745                 750                       

gtg ttg agg gaa aac aca tcc ccc aaa gcc aac aaa gaa atc tta gac       2481
Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp           
    755                 760                 765                           

gaa gca tac gtg atg gct ggt gtg ggc tcc cca tat gtc tcc cgc ctt       2529
Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu           
770                 775                 780                 785           

ctg ggc atc tgc ctg aca tcc acg gtg cag ctg gtg aca cag ctt atg       2577
Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met           
                790                 795                 800               

ccc tat ggc tgc ctc tta gac cat gtc cgg gaa aac cgc gga cgc ctg       2625
Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu           
            805                 810                 815                   

ggc tcc cag gac ctg ctg aac tgg tgt atg cag att gcc aag ggg atg       2673
Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met           
        820                 825                 830                       

agc tac ctg gag gat gtg cgg ctc gta cac agg gac ttg gcc gct cgg       2721
Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg           
    835                 840                 845                           

aac gtg ctg gtc aag agt ccc aac cat gtc aaa att aca gac ttc ggg       2769
Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly           
850                 855                 860                 865           

ctg gct cgg ctg ctg gac att gac gag aca gag tac cat gca gat ggg       2817
Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly           
                870                 875                 880               

ggc aag gtg ccc atc aag tgg atg gcg ctg gag tcc att ctc cgc cgg       2865
Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg           
            885                 890                 895                   

cgg ttc acc cac cag agt gat gtg tgg agt tat ggt gtg act gtg tgg       2913
Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp           
        900                 905                 910                       

gag ctg atg act ttt ggg gcc aaa cct tac gat ggg atc cca gcc cgg       2961
Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg           
    915                 920                 925                           

gag atc cct gac ctg ctg gaa aag ggg gag cgg ctg ccc cag ccc ccc       3009
Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro           
930                 935                 940                 945           

atc tgc acc att gat gtc tac atg atc atg gtc aaa tgt tgg atg att       3057
Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile           
                950                 955                 960               

gac tct gaa tgt cgg cca aga ttc cgg gag ttg gtg tct gaa ttc tcc       3105
Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser           
            965                 970                 975                   

cgc atg gcc agg gac ccc cag cgc ttt gtg gtc atc cag aat gag gac       3153
Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp           
        980                 985                 990                       

ttg ggc cca gcc agt ccc ttg  gac agc acc ttc tac  cgc tca ctg ctg     3201
Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu Leu         
    995                 1000                 1005                         

gag  gac gat gac atg ggg  gac ctg gtg gat gct  gag gag tat ctg        3246
Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr Leu            
1010                 1015                 1020                            

gta  ccc cag cag ggc ttc  ttc tgt cca gac cct  gcc ccg ggc gct        3291
Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly Ala            
1025                 1030                 1035                            

ggg  ggc atg gtc cac cac  agg cac cgc agc tca  tct acc agg agt        3336
Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg Ser            
1040                 1045                 1050                            

ggc  ggt ggg gac ctg aca  cta ggg ctg gag ccc  tct gaa gag gag        3381
Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu Glu            
1055                 1060                 1065                            

gcc  ccc agg tct cca ctg  gca ccc tcc gaa ggg  gct ggc tcc gat        3426
Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser Asp            
1070                 1075                 1080                            

gta  ttt gat ggt gac ctg  gga atg ggg gca gcc  aag ggg ctg caa        3471
Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu Gln            
1085                 1090                 1095                            

agc  ctc ccc aca cat gac  ccc agc cct cta cag  cgg tac agt gag        3516
Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser Glu            
1100                 1105                 1110                            

gac  ccc aca gta ccc ctg  ccc tct gag act gat  ggc tac gtt gcc        3561
Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val Ala            
1115                 1120                 1125                            

ccc  ctg acc tgc agc ccc  cag cct gaa tat gtg  aac cag cca gat        3606
Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro Asp            
1130                 1135                 1140                            

gtt  cgg ccc cag ccc cct  tcg ccc cga gag ggc  cct ctg cct gct        3651
Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro Ala            
1145                 1150                 1155                            

gcc  cga cct gct ggt gcc  act ctg gaa agg ccc  aag act ctc tcc        3696
Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu Ser            
1160                 1165                 1170                            

cca  ggg aag aat ggg gtc  gtc aaa gac gtt ttt  gcc ttt ggg ggt        3741
Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly Gly            
1175                 1180                 1185                            

gcc  gtg gag aac ccc gag  tac ttg aca ccc cag  gga gga gct gcc        3786
Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala Ala            
1190                 1195                 1200                            

cct  cag ccc cac cct cct  cct gcc ttc agc cca  gcc ttc gac aac        3831
Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp Asn            
1205                 1210                 1215                            

ctc  tat tac tgg gac cag  gac cca cca gag cgg  ggg gct cca ccc        3876
Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro Pro            
1220                 1225                 1230                            

agc  acc ttc aaa ggg aca  cct acg gca gag aac  cca gag tac ctg        3921
Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr Leu            
1235                 1240                 1245                            

ggt  ctg gac gtg cca gtg  tga accagaaggc caagtccgca gaagccctga        3972
Gly  Leu Asp Val Pro Val                                                  
1250                 1255                                                 

tgtgtcctca gggagcaggg aaggcctgac ttctgctggc atcaagaggt gggagggccc     4032

tccgaccact tccaggggaa cctgccatgc caggaacctg tcctaaggaa ccttccttcc     4092

tgcttgagtt cccagatggc tggaaggggt ccagcctcgt tggaagagga acagcactgg     4152

ggagtctttg tggattctga ggccctgccc aatgagactc tagggtccag tggatgccac     4212

agcccagctt ggccctttcc ttccagatcc tgggtactga aagccttagg gaagctggcc     4272

tgagagggga agcggcccta agggagtgtc taagaacaaa agcgacccat tcagagactg     4332

tccctgaaac ctagtactgc cccccatgag gaaggaacag caatggtgtc agtatccagg     4392

ctttgtacag agtgcttttc tgtttagttt ttactttttt tgttttgttt ttttaaagat     4452

gaaataaaga cccaggggga g                                               4473


<210>  24
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  25
<211>  1212
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1212)

<400>  25
atg aca gcc atc atc aaa gag atc gtt agc aga aac aaa agg aga tat         48
Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr           
1               5                   10                  15                

caa gag gat gga ttc gac tta gac ttg acc tat att tat cca aac att         96
Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile           
            20                  25                  30                    

att gct atg gga ttt cct gca gaa aga ctt gaa ggc gta tac agg aac        144
Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn           
        35                  40                  45                        

aat att gat gat gta gta agg ttt ttg gat tca aag cat aaa aac cat        192
Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His           
    50                  55                  60                            

tac aag ata tac aat ctt tgt gct gaa aga cat tat gac acc gcc aaa        240
Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys           
65                  70                  75                  80            

ttt aat tgc aga gtt gca caa tat cct ttt gaa gac cat aac cca cca        288
Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro           
                85                  90                  95                

cag cta gaa ctt atc aaa ccc ttt tgt gaa gat ctt gac caa tgg cta        336
Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu           
            100                 105                 110                   

agt gaa gat gac aat cat gtt gca gca att cac tgt aaa gct gga aag        384
Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys           
        115                 120                 125                       

gga cga act ggt gta atg ata tgt gca tat tta tta cat cgg ggc aaa        432
Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys           
    130                 135                 140                           

ttt tta aag gca caa gag gcc cta gat ttc tat ggg gaa gta agg acc        480
Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr           
145                 150                 155                 160           

aga gac aaa aag gga gta act att ccc agt cag agg cgc tat gtg tat        528
Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr           
                165                 170                 175               

tat tat agc tac ctg tta aag aat cat ctg gat tat aga cca gtg gca        576
Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala           
            180                 185                 190                   

ctg ttg ttt cac aag atg atg ttt gaa act att cca atg ttc agt ggc        624
Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly           
        195                 200                 205                       

gga act tgc aat cct cag ttt gtg gtc tgc cag cta aag gtg aag ata        672
Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile           
    210                 215                 220                           

tat tcc tcc aat tca gga ccc aca cga cgg gaa gac aag ttc atg tac        720
Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr           
225                 230                 235                 240           

ttt gag ttc cct cag ccg tta cct gtg tgt ggt gat atc aaa gta gag        768
Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu           
                245                 250                 255               

ttc ttc cac aaa cag aac aag atg cta aaa aag gac aaa atg ttt cac        816
Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His           
            260                 265                 270                   

ttt tgg gta aat aca ttc ttc ata cca gga cca gag gaa acc tca gaa        864
Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu           
        275                 280                 285                       

aaa gta gaa aat gga agt cta tgt gat caa gaa atc gat agc att tgc        912
Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys           
    290                 295                 300                           

agt ata gag cgt gca gat aat gac aag gaa tat cta gta ctt act tta        960
Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu           
305                 310                 315                 320           

aca aaa aat gat ctt gac aaa gca aat aaa gac aaa gcc aac cga tac       1008
Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr           
                325                 330                 335               

ttt tct cca aat ttt aag gtg aag ctg tac ttc aca aaa aca gta gag       1056
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu           
            340                 345                 350                   

gag ccg tca aat cca gag gct agc agt tca act tct gta aca cca gat       1104
Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp           
        355                 360                 365                       

gtt agt gac aat gaa cct gat cat tat aga tat tct gac acc act gac       1152
Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp           
    370                 375                 380                           

tct gat cca gag aat gaa cct ttt gat gaa gat cag cat aca caa att       1200
Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile           
385                 390                 395                 400           

aca aaa gtc tga                                                       1212
Thr Lys Val                                                               
                                                                          


<210>  26
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  27
<211>  597
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(597)

<400>  27
atg tca aac gtg cga gtg tct aac ggg agc cct agc ctg gag cgg atg         48
Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met           
1               5                   10                  15                

gac gcc agg cag gcg gag cac ccc aag ccc tcg gcc tgc agg aac ctc         96
Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu           
            20                  25                  30                    

ttc ggc ccg gtg gac cac gaa gag tta acc cgg gac ttg gag aag cac        144
Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His           
        35                  40                  45                        

tgc aga gac atg gaa gag gcg agc cag cgc aag tgg aat ttc gat ttt        192
Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe           
    50                  55                  60                            

cag aat cac aaa ccc cta gag ggc aag tac gag tgg caa gag gtg gag        240
Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu           
65                  70                  75                  80            

aag ggc agc ttg ccc gag ttc tac tac aga ccc ccg cgg ccc ccc aaa        288
Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys           
                85                  90                  95                

ggt gcc tgc aag gtg ccg gcg cag gag agc cag gat gtc agc ggg agc        336
Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser           
            100                 105                 110                   

cgc ccg gcg gcg cct tta att ggg gct ccg gct aac tct gag gac acg        384
Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr           
        115                 120                 125                       

cat ttg gtg gac cca aag act gat ccg tcg gac agc cag acg ggg tta        432
His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu           
    130                 135                 140                           

gcg gag caa tgc gca gga ata agg aag cga cct gca acc gac gat tct        480
Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser           
145                 150                 155                 160           

tct act caa aac aaa aga gcc aac aga aca gaa gaa aat gtt tca gac        528
Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp           
                165                 170                 175               

ggt tcc cca aat gcc ggt tct gtg gag cag acg ccc aag aag cct ggc        576
Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly           
            180                 185                 190                   

ctc aga aga cgt caa acg taa                                            597
Leu Arg Arg Arg Gln Thr                                                   
        195                                                               


<210>  28
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


<210>  29
<211>  894
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(894)

<400>  29
atg aca aca ccc aga aat tca gta aat ggg act ttc ccg gca gag cca         48
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro           
1               5                   10                  15                

atg aaa ggc cct att gct atg caa tct ggt cca aaa cca ctc ttc agg         96
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg           
            20                  25                  30                    

agg atg tct tca ctg gtg ggc ccc acg caa agc ttc ttc atg agg gaa        144
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu           
        35                  40                  45                        

tct aag act ttg ggg gct gtc cag att atg aat ggg ctc ttc cac att        192
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile           
    50                  55                  60                            

gcc ctg ggg ggt ctt ctg atg atc cca gca ggg atc tat gca ccc atc        240
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile           
65                  70                  75                  80            

tgt gtg act gtg tgg tac cct ctc tgg gga ggc att atg tat att att        288
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile           
                85                  90                  95                

tcc gga tca ctc ttg gca gca acg gag aaa aac tct agg aag tgt ttg        336
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu           
            100                 105                 110                   

gtc aaa gga aaa atg ata atg aat tca ttg agc ctc ttt gct gcc att        384
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile           
        115                 120                 125                       

tct gga atg att ctt tca atc atg gac ata ctt aat att aaa att tcc        432
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser           
    130                 135                 140                           

cat ttt tta aaa atg gag agt ctg aat ttt att aga gct cac aca cca        480
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro           
145                 150                 155                 160           

tat att aac ata tac aac tgt gaa cca gct aat ccc tct gag aaa aac        528
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn           
                165                 170                 175               

tcc cca tct acc caa tac tgt tac agc ata caa tct ctg ttc ttg ggc        576
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly           
            180                 185                 190                   

att ttg tca gtg atg ctg atc ttt gcc ttc ttc cag gaa ctt gta ata        624
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile           
        195                 200                 205                       

gct ggc atc gtt gag aat gaa tgg aaa aga acg tgc tcc aga ccc aaa        672
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys           
    210                 215                 220                           

tct aac ata gtt ctc ctg tca gca gaa gaa aaa aaa gaa cag act att        720
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile           
225                 230                 235                 240           

gaa ata aaa gaa gaa gtg gtt ggg cta act gaa aca tct tcc caa cca        768
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro           
                245                 250                 255               

aag aat gaa gaa gac att gaa att att cca atc caa gaa gag gaa gaa        816
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu           
            260                 265                 270                   

gaa gaa aca gag acg aac ttt cca gaa cct ccc caa gat cag gaa tcc        864
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser           
        275                 280                 285                       

tca cca ata gaa aat gac agc tct cct taa                                894
Ser Pro Ile Glu Asn Asp Ser Ser Pro                                       
    290                 295                                               


<210>  30
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  31
<211>  596
<212>  DNA
<213>  homo sapiens

<400>  31
acgcgtactg gagtcaatga aagcaactat ttcaaaagat cagattactt accagtttca       60

ctaataaaga tttattactt taaaccttta tcataaaatg tatgctttga atactgtgaa      120

gtacactgca tataaggagt gtggtatagt ataaagaaac tttctgcagg tagtaattat      180

agtgaagatt ttaggtttac aaagccctag ctgttttctg tgtagctttt attattctta      240

tgactcttga caagtttgta gcttcaccat atacatttaa tattttgcaa taattggcct      300

tgttcctgag ctgttggatt cggggccgta gcactgtctg agaggtttac atttctcaca      360

gtgaaccggt ctctttttca gctgcttcct ggcttctttt tactcaggtt tccactgctt      420

ttttgctttt tttaatgctg tatgaaggtg ttaacatttg tttatatttt tcattaattg      480

taataccttt aaatcatgca tcatactcag aaatagggat tagaatttaa gtgacatctt      540

tggcctaata taatttacct gttaaaaatt tgtgaaagct attgcttagc ggccgc          596


<210>  32
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  32
acgcgtccat gtccgtacct ttctagttca taccttcttt taattttttt tttcttttca       60

atttgaagag agtgcttcct ctgttcttaa ggctagggaa ccaaattagg ttgtttcaat      120

atcgtgctaa aagatactgc ctttagaaga aggctattga caatccagcg tgtctcggtg      180

gaactctgac tccatggttc actttcatga tggccacatg cctcctgccc agagcccggc      240

agccactgtg cagtgggaag gggggccgat acactgtacg agagtgagta gcaggtctca      300

cagtgaaccg gtctctttcc ctactgtgtc acactcctaa tggaatgccg ttatccaaag      360

agcagcacga acccgacagg gctgagtggc ttgtgctagg gagaggtttg tgtcattcct      420

gctgaccaaa ctgcaggaaa aactgctaat tgtcatgctg aagactgcct gacggggaga      480

ctctgccttc tgtaagtagg tcagcggccg c                                     511


<210>  33
<211>  203
<212>  DNA
<213>  Homo sapiens

<400>  33
acgcgtaatt catatttgca tgtcgctatg tgttctggga aatcaccata aacgtgaaat       60

gtctttggat ttgggaatct tataagttct gtatgagacc actcggatga gctgttggat      120

tcggggccgt agcactgtct gagaggttta catttctcac agtgaaccgg tctctttttc      180

agctgcttct tttttgcggc cgc                                              203


<210>  34
<211>  205
<212>  DNA
<213>  Homo sapiens

<400>  34
gcggccgcaa ttcatatttg catgtcgcta tgtgttctgg gaaatcacca taaacgtgaa       60

atgtctttgg atttgggaat cttataagtt ctgtatgaga ccactcggat gagctgttgg      120

attcggggcc gtagcactgt ctgagaggtt tacatttctc acagtgaacc ggtctctttt      180

tcagctgctt cttttttgcg gccgc                                            205


<210>  35
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA target sequence of the miR-142-3p

<400>  35
gcggccgcgt cgactccata aagtaggaaa cactacagcg gccgc                       45


<210>  36
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA target sequence four time repeat miR-142-3pT4X

<400>  36
gcggccgcgt cgactccata aagtaggaaa cactacacga ttccataaag taggaaacac       60

tacaaccggt tccataaagt aggaaacact acatcactcc ataaagtagg aaacactaca      120

gcggccgc                                                               128


<210>  37
<211>  1131
<212>  DNA
<213>  herpes simplex virus 1

<400>  37
atggcttcgt accccggcca tcagcacgcg tctgcgttcg accaggctgc gcgttctcgc       60

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc      120

cgcccggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc ccacgggatg      180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac      240

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc      300

tacaccacac aacaccgcct cgaccagggt gagatatcgg ccggggacgc ggcggtggta      360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct      420

cctcatatcg ggggggaggc tgggagctca catgccccgc ccccggccct caccctcatc      480

ttcgaccgcc atcccatcgc cgccctcctg tgttacccgg ccgcgcgata ccttatgggc      540

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc      600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc      660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacgag      720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggcggga ggattgggga      780

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca      840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc      900

aacggcgacc tgtataacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt      960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctaccg ggacgccctg     1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca cccccggctc cataccgacg     1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaacta a              1131


<210>  38
<211>  499
<212>  DNA
<213>  Homo sapiens

<400>  38
atgaaatata caagttatat cttggctttt cagctctgca tcgttttggg ttctcttggc       60

tgttactgcc aggaccatat gtaaaagaag cagaaaacct taagaaatat tttaatgcag      120

gtcattcaga tgtagcggat aatggaactc ttttcttagg cattttgaag aattggaaag      180

aggagagtga cagaaaaata atgcagagcc aaattgtctc cttttacttc aaacttttta      240

aaaactttaa agatgaccag agcatccaaa agagtgtgga gaccatcaag gaagacatga      300

atgtaagttt ttcaatagca acaaaaagaa acgagatgac ttcgaaaagc tgactaatta      360

ttcggtaact gacttgaatg tccaacgcaa agcaatacat gaactcatcc aagtgatggc      420

tgaactgtcg ccagcagcta aaacagggaa gcgaaaaagg agtcagatgc tgtttcgagg      480

tcgaagagca tcccagtaa                                                   499


<210>  39
<211>  468
<212>  DNA
<213>  Mus musculus

<400>  39
atgaacgcta cacactgcat cttggctttg cagctcttcc tcatggctgt ttctggctgt       60

tactgccacg gcacagtcat tgaaagccta gaaagtctga ataactattt taactcaagt      120

ggcatagatg tggaagaaaa gagtctcttc ttggatatct ggaggaactg gcaaaaggat      180

ggtgacatga aaatcctgca gagccagatt atctctttct acctcagact ctttgaagtc      240

ttgaaagaca atcaggccat cagcaacaac ataagcgtca ttgaatcaca cctgattact      300

accttcttca gcaacagcaa ggcgaaaaag gatgcattca tgagtattgc caagtttgag      360

gtcaacaacc cacaggtcca gcgccaagca ttcaatgagc tcatccgagt ggtccaccag      420

ctgttgccgg aatccagcct caggaagcgg aaaaggagtc gctgctga                   468


<210>  40
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  40
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210>  41
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  41
uguaguguuu ccuacuuuau gga                                               23


<210>  42
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  42
uguaguguuu ccuacuuuau gga                                               23


<210>  43
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast cytosine deaminase with cloning sites

<400>  43
aacacgatta taaatggtga cagggggaat ggcaagcaag tgggatcaga agggtatgga       60

cattgcctat gaggaggcgg ccttaggtta caaagagggt ggtgttccta ttggcggatg      120

tcttatcaat aacaaagacg gaagtgttct cggtcgtggt cacaacatga gatttcaaaa      180

gggatccgcc acactacatg gtgagatctc cactttggaa aactgtggga gattagaggg      240

caaagtgtac aaagatacca ctttgtatac gacgctgtct ccatgcgaca tgtgtacagg      300

tgccatcatc atgtatggta ttccacgctg tgttgtcggt gagaacgtta atttcaaaag      360

taagggcgag aaatatttac aaactagagg tcacgaggtt gttgttgttg acgatgagag      420

gtgtaaaaag atcatgaaac aatttatcga tgaaagacct caggattggt ttgaagatat      480

tggtgagtag gcggccgcgc catagataaa ataaaagatt ttatttagtc tccagaaaaa      540

gggggg                                                                 546


<210>  44
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD codon optimized with cloning sites

<400>  44
ttataaatgg tgaccggcgg catggcctcc aagtgggatc aaaagggcat ggatatcgct       60

tacgaggagg ccgccctggg ctacaaggag ggcggcgtgc ctatcggcgg ctgtctgatc      120

aacaacaagg acggcagtgt gctgggcagg ggccacaaca tgaggttcca gaagggctcc      180

gccaccctgc acggcgagat ctccaccctg gagaactgtg gcaggctgga gggcaaggtg      240

tacaaggaca ccaccctgta caccaccctg tccccttgtg acatgtgtac cggcgctatc      300

atcatgtacg gcatccctag gtgtgtggtg ggcgagaacg tgaacttcaa gtccaagggc      360

gagaagtacc tgcaaaccag gggccacgag gtggtggttg ttgacgatga gaggtgtaag      420

aagatcatga agcagttcat cgacgagagg cctcaggact ggttcgagga tatcggcgag      480

tgataagcgg ccgcagataa aataaaagat tttatttagt ctccagaaaa agggggg         537


<210>  45
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  45
tcgaggatat cggcgagtga aacccgttat tctttttggc                             40


<210>  46
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  46
gccaaaaaga ataacgggtt tcactcgccg atatcctcga                             40


<210>  47
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  47
tcggcgagtg atccggcggc ggcgcctccg gcggcggcgc ctccggcggc ggcgcctccg       60

gcggcggcgc caacccgtta tt                                                82


<210>  48
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  48
aataacgggt tggcgccgcc gccggaggcg ccgccgccgg aggcgccgcc gccggaggcg       60

ccgccgccgg atcactcgcc ga                                                82


<210>  49
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cytosine deaminase codon optimized heat stabilized

<400>  49
atggtgaccg gcggcatggc ctccaagtgg gatcaaaagg gcatggatat cgcttacgag       60

gaggccctgc tgggctacaa ggagggcggc gtgcctatcg gcggctgtct gatcaacaac      120

aaggacggca gtgtgctggg caggggccac aacatgaggt tccagaaggg ctccgccacc      180

ctgcacggcg agatctccac cctggagaac tgtggcaggc tggagggcaa ggtgtacaag      240

gacaccaccc tgtacaccac cctgtcccct tgtgacatgt gtaccggcgc tatcatcatg      300

tacggcatcc ctaggtgtgt gatcggcgag aacgtgaact tcaagtccaa gggcgagaag      360

tacctgcaaa ccaggggcca cgaggtggtg gttgttgacg atgagaggtg taagaagctg      420

atgaagcagt tcatcgacga gaggcctcag gactggttcg aggatatcgg cgagtgataa      480


<210>  50
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cytosine deaminase codon optimized heat stabilized

<400>  50
aacacgatta taaatggtga ccggcggcat ggcctccaag tgggatcaaa agggcatgga       60

tatcgcttac gaggaggccc tgctgggcta caaggagggc ggcgtgccta tcggcggctg      120

tctgatcaac aacaaggacg gcagtgtgct gggcaggggc cacaacatga ggttccagaa      180

gggctccgcc accctgcacg gcgagatctc caccctggag aactgtggca ggctggaggg      240

caaggtgtac aaggacacca ccctgtacac caccctgtcc ccttgtgaca tgtgtaccgg      300

cgctatcatc atgtacggca tccctaggtg tgtgatcggc gagaacgtga acttcaagtc      360

caagggcgag aagtacctgc aaaccagggg ccacgaggtg gtggttgttg acgatgagag      420

gtgtaagaag ctgatgaagc agttcatcga cgagaggcct caggactggt tcgaggatat      480

cggcgagtaa gcggccgcgc catagataaa ataaaagatt ttatttagtc tccagaaaaa      540

gggggg                                                                 546


<210>  51
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  51
tcgaggatat cggcgagtga aacccgttat tctttttggc                             40


<210>  52
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  52
gccaaaaaga ataacgggtt tcactcgccg atatcctcga                             40


<210>  53
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer complement

<400>  53
ccaagctcct atagccgctc actatctact tgggcaataa gaaaaaccga ag               52


<210>  54
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer complement

<400>  54
ggttcgagga tatcggcgag tgatagatga acccgttatt ctttttggct tc               52


<210>  55
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD-UPRT cloning sequence

<400>  55
aacacgatta taaatggtga ccggcggcat ggcctccaag tgggatcaaa agggcatgga       60

tatcgcttac gaggaggccc tgctgggcta caaggagggc ggcgtgccta tcggcggctg      120

tctgatcaac aacaaggacg gcagtgtgct gggcaggggc cacaacatga ggttccagaa      180

gggctccgcc accctgcacg gcgagatctc caccctggag aactgtggca ggctggaggg      240

caaggtgtac aaggacacca ccctgtacac caccctgtcc ccttgtgaca tgtgtaccgg      300

cgctatcatc atgtacggca tccctaggtg tgtgatcggc gagaacgtga acttcaagtc      360

caagggcgag aagtacctgc aaaccagggg ccacgaggtg gtggttgttg acgatgagag      420

gtgtaagaag ctgatgaagc agttcatcga cgagaggcct caggactggt tcgaggatat      480

cggcgagaac ccgttattct ttttggcttc tccattcttg taccttacat atcttatata      540

ttatccaaac aaagggtctt tcgttagcaa acctagaaat ctgcaaaaaa tgtcttcgga      600

accatttaag aacgtctact tgctacctca aacaaaccaa ttgctgggtt tgtacaccat      660

catcagaaat aagaatacaa ctagacctga tttcattttc tactccgata gaatcatcag      720

attgttggtt gaagaaggtt tgaaccatct acctgtgcaa aagcaaattg tggaaactga      780

caccaacgaa aacttcgaag gtgtctcatt catgggtaaa atctgtggtg tttccattgt      840

cagagctggt gaatcgatgg agcaaggatt aagagactgt tgtaggtctg tgcgtatcgg      900

taaaatttta attcaaaggg acgaggagac tgctttacca aagttattct acgaaaaatt      960

accagaggat atatctgaaa ggtatgtctt cctattagac ccaatgctgg ccaccggtgg     1020

tagtgctatc atggctacag aagtcttgat taagagaggt gttaagccag agagaattta     1080

cttcttaaac ctaatctgta gtaaggaagg gattgaaaaa taccatgccg ccttcccaga     1140

ggtcagaatt gttactggtg ccctcgacag aggtctagat gaaaacaagt atctagttcc     1200

agggttgggt gactttggtg acagatacta ctgtgtttaa gcggccgcgc catagataaa     1260

ataaaagatt ttatttagtc tccagaaaaa gggggg                               1296


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  56

Ser Gly Gly Gly Gly 
1               5   


<210>  57
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  57
tcggcgagtg atccggcggc ggcgcctccg gcggcggcgc ctccggcggc ggcgcctccg       60

gcggcggcgc caacccgtta tt                                                82


<210>  58
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  58
aataacgggt tggcgccgcc gccggaggcg ccgccgccgg aggcgccgcc gccggaggcg       60

ccgccgccgg atcactcgcc ga                                                82


<210>  59
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD codon optimized heat stabilized linker UPRT

<400>  59
aacacgatta taaatggtga ccggcggcat ggcctccaag tgggatcaaa agggcatgga       60

tatcgcttac gaggaggccc tgctgggcta caaggagggc ggcgtgccta tcggcggctg      120

tctgatcaac aacaaggacg gcagtgtgct gggcaggggc cacaacatga ggttccagaa      180

gggctccgcc accctgcacg gcgagatctc caccctggag aactgtggca ggctggaggg      240

caaggtgtac aaggacacca ccctgtacac caccctgtcc ccttgtgaca tgtgtaccgg      300

cgctatcatc atgtacggca tccctaggtg tgtgatcggc gagaacgtga acttcaagtc      360

caagggcgag aagtacctgc aaaccagggg ccacgaggtg gtggttgttg acgatgagag      420

gtgtaagaag ctgatgaagc agttcatcga cgagaggcct caggactggt tcgaggatat      480

cggcgagtcc ggcggcggcg cctccggcgg cggcgcctcc ggcggcggcg cctccggcgg      540

cggcgccaac ccgttattct ttttggcttc tccattcttg taccttacat atcttatata      600

ttatccaaac aaagggtctt tcgttagcaa acctagaaat ctgcaaaaaa tgtcttcgga      660

accatttaag aacgtctact tgctacctca aacaaaccaa ttgctgggtt tgtacaccat      720

catcagaaat aagaatacaa ctagacctga tttcattttc tactccgata gaatcatcag      780

attgttggtt gaagaaggtt tgaaccatct acctgtgcaa aagcaaattg tggaaactga      840

caccaacgaa aacttcgaag gtgtctcatt catgggtaaa atctgtggtg tttccattgt      900

cagagctggt gaatcgatgg agcaaggatt aagagactgt tgtaggtctg tgcgtatcgg      960

taaaatttta attcaaaggg acgaggagac tgctttacca aagttattct acgaaaaatt     1020

accagaggat atatctgaaa ggtatgtctt cctattagac ccaatgctgg ccaccggtgg     1080

tagtgctatc atggctacag aagtcttgat taagagaggt gttaagccag agagaattta     1140

cttcttaaac ctaatctgta gtaaggaagg gattgaaaaa taccatgccg ccttcccaga     1200

ggtcagaatt gttactggtg ccctcgacag aggtctagat gaaaacaagt atctagttcc     1260

agggttgggt gactttggtg acagatacta ctgtgtttaa gcggccgcgc catagataaa     1320

ataaaagatt ttatttagtc tccagaaaaa gggggg                               1356


<210>  60
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD codon optimized heat stabilized OPRT

<400>  60
aacacgatta taaatggtga ccggcggcat ggcctccaag tgggatcaaa agggcatgga       60

tatcgcttac gaggaggccc tgctgggcta caaggagggc ggcgtgccta tcggcggctg      120

tctgatcaac aacaaggacg gcagtgtgct gggcaggggc cacaacatga ggttccagaa      180

gggctccgcc accctgcacg gcgagatctc caccctggag aactgtggca ggctggaggg      240

caaggtgtac aaggacacca ccctgtacac caccctgtcc ccttgtgaca tgtgtaccgg      300

cgctatcatc atgtacggca tccctaggtg tgtgatcggc gagaacgtga acttcaagtc      360

caagggcgag aagtacctgc aaaccagggg ccacgaggtg gtggttgttg acgatgagag      420

gtgtaagaag ctgatgaagc agttcatcga cgagaggcct caggactggt tcgaggatat      480

cggcgaggcg gtcgctcgtg cagctttggg gccattggtg acgggtctgt acgacgtgca      540

ggctttcaag tttggggact tcgtgctgaa gagcgggctt tcctccccca tctacatcga      600

tctgcggggc atcgtgtctc gaccgcgtct tctgagtcag gttgcagata ttttattcca      660

aactgcccaa aatgcaggca tcagttttga caccgtgtgt ggagtgcctt atacagcttt      720

gccattggct acagttatct gttcaaccaa tcaaattcca atgcttatta gaaggaaaga      780

aacaaaggat tatggaacta agcgtcttgt agaaggaact attaatccag gagaaacctg      840

tttaatcatt gaagatgttg tcaccagtgg atctagtgtt ttggaaactg ttgaggttct      900

tcagaaggag ggcttgaagg tcactgatgc catagtgctg ttggacagag agcagggagg      960

caaggacaag ttgcaggcgc acgggatccg cctccactca gtgtgtacat tgtccaaaat     1020

gctggagatt ctcgagcagc agaaaaaagt tgatgctgag acagttggga gagtgaagag     1080

gtttattcag gagaatgtct ttgtggcagc gaatcataat ggttctcccc tttctataaa     1140

ggaagcaccc aaagaactca gcttcggtgc acgtgcagag ctgcccagga tccacccagt     1200

tgcatcgaag taagcggccg cgccatagat aaaataaaag attttattta gtctccagaa     1260

aaagggggg                                                             1269


<210>  61
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD codon optimized heat stabilized linker OPRT

<400>  61
aacacgatta taaatggtga ccggcggcat ggcctccaag tgggatcaaa agggcatgga       60

tatcgcttac gaggaggccc tgctgggcta caaggagggc ggcgtgccta tcggcggctg      120

tctgatcaac aacaaggacg gcagtgtgct gggcaggggc cacaacatga ggttccagaa      180

gggctccgcc accctgcacg gcgagatctc caccctggag aactgtggca ggctggaggg      240

caaggtgtac aaggacacca ccctgtacac caccctgtcc ccttgtgaca tgtgtaccgg      300

cgctatcatc atgtacggca tccctaggtg tgtgatcggc gagaacgtga acttcaagtc      360

caagggcgag aagtacctgc aaaccagggg ccacgaggtg gtggttgttg acgatgagag      420

gtgtaagaag ctgatgaagc agttcatcga cgagaggcct caggactggt tcgaggatat      480

cggcgagtcc ggcggcggcg cctccggcgg cggcgcctcc ggcggcggcg cctccggcgg      540

cggcgccgcg gtcgctcgtg cagctttggg gccattggtg acgggtctgt acgacgtgca      600

ggctttcaag tttggggact tcgtgctgaa gagcgggctt tcctccccca tctacatcga      660

tctgcggggc atcgtgtctc gaccgcgtct tctgagtcag gttgcagata ttttattcca      720

aactgcccaa aatgcaggca tcagttttga caccgtgtgt ggagtgcctt atacagcttt      780

gccattggct acagttatct gttcaaccaa tcaaattcca atgcttatta gaaggaaaga      840

aacaaaggat tatggaacta agcgtcttgt agaaggaact attaatccag gagaaacctg      900

tttaatcatt gaagatgttg tcaccagtgg atctagtgtt ttggaaactg ttgaggttct      960

tcagaaggag ggcttgaagg tcactgatgc catagtgctg ttggacagag agcagggagg     1020

caaggacaag ttgcaggcgc acgggatccg cctccactca gtgtgtacat tgtccaaaat     1080

gctggagatt ctcgagcagc agaaaaaagt tgatgctgag acagttggga gagtgaagag     1140

gtttattcag gagaatgtct ttgtggcagc gaatcataat ggttctcccc tttctataaa     1200

ggaagcaccc aaagaactca gcttcggtgc acgtgcagag ctgcccagga tccacccagt     1260

tgcatcgaag taagcggccg cgccatagat aaaataaaag attttattta gtctccagaa     1320

aaagggggg                                                             1329


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  62
ctgatcttac tctttggacc ttg                                               23


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  63
cccctttttc tggagactaa ataa                                              24


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  64
agcccacaac ccctcactc                                                    19


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  65
tctcccgatc ccggacga                                                     18


<210>  66
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  66
ccccaaatga aagacccccg ctgacg                                            26


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  67
atcatcatgt acggcatccc tag                                               23


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  68
tgaactgctt catcagcttc ttac                                              24


<210>  69
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  69
tcatcgtcaa caaccaccac ctcgt                                             25


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  70
aacctcaacc tcccctacaa gt                                                22


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  71
gttaagcgcc tgataggctc                                                   20


<210>  72
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  72
agccaccccc aggaactgga gataga                                            26


<210>  73
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  73

Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Lys Asp Leu 
1               5                   10                  15      


Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn 
            20                  25              


