                               SEQUENCE LISTING	

<110> PFENEX, INC.
      
<120> HIGH LEVEL EXPRESSION OF RECOMBINANT TOXIN PROTEINS

<130> 38194-735.601

<140>
<141>

<150> 61/325,235
<151> 2010-04-16

<150> PCT/US10/30573
<151> 2010-04-09

<150> 61/319,152
<151> 2010-03-30

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 535
<212> PRT
<213> Corynebacterium diphtheriae

<400> 1
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210> 2
<211> 1605
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(1605)

<400> 2
ggg gcg gac gat gtg gtg gat tcc tcc aag tcg ttt gtc atg gaa aat         48
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn           
1               5                   10                  15                

ttc tcg tcg tac cat ggc act aag cca ggc tac gtg gat agc att caa         96
Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln           
            20                  25                  30                    

aag ggc atc cag aag ccc aag agc ggt act cag ggg aac tat gac gac        144
Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp           
        35                  40                  45                        

gac tgg aag gaa ttt tac agc acc gac aat aag tac gat gct gcg ggc        192
Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly           
    50                  55                  60                            

tat agc gtg gac aac gaa aac cca ttg tcg ggc aag gcc ggt ggc gtg        240
Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val           
65                  70                  75                  80            

gtg aag gtg acc tat cct ggt ctg acg aaa gtt ctg gcg ttg aaa gtg        288
Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val           
                85                  90                  95                

gac aac gcc gag act atc aag aaa gaa ttg ggc ttg agt ttg acc gag        336
Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu           
            100                 105                 110                   

ccg ctg atg gaa cag gtg ggt acc gaa gaa ttc att aaa cgt ttt ggg        384
Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly           
        115                 120                 125                       

gac ggc gcg tcg cgc gtg gtc ctg tcg ttg ccg ttc gcc gaa ggg tcg        432
Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser           
    130                 135                 140                           

tcg tcg gtg gaa tat atc aac aac tgg gaa cag gcc aag gcg ctg tcg        480
Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser           
145                 150                 155                 160           

gtg gaa ctg gaa att aac ttc gaa acg cgg ggc aaa cgg ggc cag gac        528
Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp           
                165                 170                 175               

gcc atg tac gaa tac atg gcg cag gcg tgc gcc ggg aac cgg gtg cgg        576
Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg           
            180                 185                 190                   

cgc agc gtg ggc agt tcc ttg agt tgc atc aat ctg gac tgg gac gtc        624
Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val           
        195                 200                 205                       

atc cgc gat aag acg aag acg aaa atc gag tcg ctc aaa gag cac ggc        672
Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly           
    210                 215                 220                           

ccg atc aaa aac aaa atg agc gag tcg ccg aat aaa acg gtg tcc gag        720
Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu           
225                 230                 235                 240           

gag aag gcg aag caa tac ctg gag gaa ttc cac cag acg gct ctg gag        768
Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu           
                245                 250                 255               

cac ccg gag ctg agc gaa ctc aaa acc gtt acc ggt acg aac ccg gtg        816
His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val           
            260                 265                 270                   

ttt gcc ggg gca aac tat gca gct tgg gcc gtc aac gtg gcc caa gtg        864
Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val           
        275                 280                 285                       

atc gac tcc gaa acg gcc gac aac ctg gaa aag act acc gcc gcg ttg        912
Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu           
    290                 295                 300                           

tcg atc ctc ccg ggc atc ggg agc gtc atg ggt att gcc gat ggt gcg        960
Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala           
305                 310                 315                 320           

gtg cat cac aac acc gaa gag atc gtc gcg cag tcg atc gca ttg tcc       1008
Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser           
                325                 330                 335               

tcc ctg atg gtc gcc caa gct atc ccg ctg gtc ggc gag ctg gtc gat       1056
Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp           
            340                 345                 350                   

atc ggc ttt gcc gct tat aac ttt gtt gaa tcg atc att aac ctg ttc       1104
Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe           
        355                 360                 365                       

cag gtg gtg cat aac agc tac aac cgg cca gcg tac tcg ccc ggt cac       1152
Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His           
    370                 375                 380                           

aag acc cag ccc ttt ctc cac gac ggc tat gcc gtg tcg tgg aac acc       1200
Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr           
385                 390                 395                 400           

gtg gag gac agc atc atc cgc acc ggt ttc cag ggc gag agc ggc cat       1248
Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His           
                405                 410                 415               

gac atc aaa att acc gcg gaa aac acg ccc ttg ccg atc gct ggc gtg       1296
Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val           
            420                 425                 430                   

ttg ctc ccg acg atc ccg ggt aag ctc gac gtc aac aag tcc aag acc       1344
Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr           
        435                 440                 445                       

cat atc agc gtc aat ggc cgc aag atc cgc atg cgc tgt cgg gcc att       1392
His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile           
    450                 455                 460                           

gat ggc gac gtc acg ttt tgc cgg ccg aag agt ccc gtc tat gtc ggg       1440
Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly           
465                 470                 475                 480           

aac ggt gtc cat gcc aac ctg cac gtc gca ttc cac cgg agc agc tcg       1488
Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser           
                485                 490                 495               

gaa aag atc cac agc aat gag atc agc agc gac agc atc ggc gtg ctg       1536
Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu           
            500                 505                 510                   

ggg tat caa aag acg gtc gat cac acc aag gtg aac agt aaa ctg agc       1584
Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser           
        515                 520                 525                       

ttg ttc ttt gaa atc aag tcg                                           1605
Leu Phe Phe Glu Ile Lys Ser                                               
    530                 535                                               


<210> 3
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Met Arg Asn Leu Ile Leu Ser Ala Ala Leu Val Thr Ala Ser Leu Phe 
1               5                   10                  15      


Gly Met Thr Ala Gln Ala 
            20          


<210> 4
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Met Phe Ala Lys Leu Val Ala Val Ser Leu Leu Thr Leu Ala Ser Gly 
1               5                   10                  15      


Gln Leu Leu Ala 
            20  


<210> 5
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Ile Arg Asp Asn Arg Leu Lys Thr Ser Leu Leu Arg Gly Leu Thr 
1               5                   10                  15      


Leu Thr Leu Leu Ser Leu Thr Leu Leu Ser Pro Ala Ala His Ala 
            20                  25                  30      


<210> 6
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Met Asn Arg Ser Ser Ala Leu Leu Leu Ala Phe Val Phe Leu Ser Gly 
1               5                   10                  15      


Cys Gln Ala Met Ala 
            20      


<210> 7
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Met Leu Phe Arg Thr Leu Leu Ala Ser Leu Thr Phe Ala Val Ile Ala 
1               5                   10                  15      


Gly Leu Pro Ser Thr Ala His Ala 
            20                  


<210> 8
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Met Ser Cys Thr Arg Ala Phe Lys Pro Leu Leu Leu Ile Gly Leu Ala 
1               5                   10                  15      


Thr Leu Met Cys Ser His Ala Phe Ala 
            20                  25  


<210> 9
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Met Arg Leu Ala Ala Leu Pro Leu Leu Leu Ala Pro Leu Phe Ile Ala 
1               5                   10                  15      


Pro Met Ala Val Ala 
            20      


<210> 10
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala Ala Gly 
1               5                   10                  15      


Val Ala Thr Val Asn Ala Val Ala 
            20                  


<210> 11
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Met Arg Leu Thr Gln Ile Ile Ala Ala Ala Ala Ile Ala Leu Val Ser 
1               5                   10                  15      


Thr Phe Ala Leu Ala 
            20      


<210> 12
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Met Arg Asn Leu Leu Arg Gly Met Leu Val Val Ile Cys Cys Met Ala 
1               5                   10                  15      


Gly Ile Ala Ala Ala 
            20      


<210> 13
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala Ala Gly 
1               5                   10                  15      


Val Ala Thr Ala Asn Ala Val Ala 
            20                  


<210> 14
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Met Gln Asn Tyr Lys Lys Phe Leu Leu Ala Ala Ala Val Ser Met Ala 
1               5                   10                  15      


Phe Ser Ala Thr Ala Met Ala 
            20              


<210> 15
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Met Pro Pro Arg Ser Ile Ala Ala Cys Leu Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Met Ala Thr Gln Ala Ala Ala 
            20              


<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Met Lys Lys Ser Thr Leu Ala Val Ala Val Thr Leu Gly Ala Ile Ala 
1               5                   10                  15      


Gln Gln Ala Gly Ala 
            20      


<210> 17
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Met Lys Leu Lys Arg Leu Met Ala Ala Met Thr Phe Val Ala Ala Gly 
1               5                   10                  15      


Val Ala Thr Ala Asn Ala Val Ala 
            20                  


<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Met Lys Phe Lys Gln Leu Met Ala Met Ala Leu Leu Leu Ala Leu Ser 
1               5                   10                  15      


Ala Val Ala Gln Ala 
            20      


<210> 19
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Gln Asn Arg Thr Val Glu Ile Gly Val Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Gly Ile Leu Ala Leu Leu Leu Leu Ala Leu Arg Val Ser Gly Leu Ser 
            20                  25                  30          


Ala 
    


<210> 20
<211> 25
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<400> 20
Met Ser Arg Lys Leu Phe Ala Ser Xaa Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala 
            20                  25  


<210> 21
<211> 4
<212> PRT
<213> Corynebacterium diphtheriae

<400> 21
Gly Ala Asp Asp 
1               


<210> 22
<211> 102
<212> PRT
<213> Vibrio cholerae

<400> 22
Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr Gln 
1               5                   10                  15      


Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu Ala 
            20                  25                  30          


Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr Phe 
        35                  40                  45              


Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala 
    50                  55                  60                  


Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu Ala 
65                  70                  75                  80  


Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro His Ala Ile 
                85                  90                  95      


Ala Ala Ile Ser Met Ala 
            100         


<210> 23
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(306)

<400> 23
acg ccg caa aat atc acc gac ctg tgc gca gaa tat cac aat acc caa         48
Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr Gln           
1               5                   10                  15                

atc cat act ctg aac gac aaa atc ttc agc tac acc gag agc ctg gct         96
Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu Ala           
            20                  25                  30                    

ggc aag cgc gag atg gcg atc att acg ttc aaa aac ggt gcg acc ttt        144
Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr Phe           
        35                  40                  45                        

cag gtg gaa gtc ccc ggc agt cag cac atc gat tcc cag aaa aag gcc        192
Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala           
    50                  55                  60                            

att gaa cgg atg aag gac acc ctc cgt atc gcc tac ttg acc gaa gcc        240
Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu Ala           
65                  70                  75                  80            

aag gtg gag aag ctg tgc gtt tgg aac aac aaa acc ccg cac gcc atc        288
Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro His Ala Ile           
                85                  90                  95                

gcg gcc atc tcg atg gcc                                                306
Ala Ala Ile Ser Met Ala                                                   
            100                                                           


<210> 24
<211> 3119
<212> DNA
<213> Bordetella pertussis


<220>
<221> CDS
<222> (1)..(807)

<220>
<221> CDS
<222> (850)..(1527)

<220>
<221> CDS
<222> (1587)..(1979)

<220>
<221> CDS
<222> (1994)..(2353)

<220>
<221> CDS
<222> (2439)..(3119)

<400> 24
atg cgt tgc act cgg gca att cgc caa acc gca aga aca ggc tgg ctg         48
Met Arg Cys Thr Arg Ala Ile Arg Gln Thr Ala Arg Thr Gly Trp Leu           
1               5                   10                  15                

acg tgg ctg gcg att ctt gcc gtc acg gcg ccc gtg act tcg ccg gca         96
Thr Trp Leu Ala Ile Leu Ala Val Thr Ala Pro Val Thr Ser Pro Ala           
            20                  25                  30                    

tgg gcc gac gat cct ccc gcc acc gta tac aaa tat gac tcc cgc ccg        144
Trp Ala Asp Asp Pro Pro Ala Thr Val Tyr Lys Tyr Asp Ser Arg Pro           
        35                  40                  45                        

ccg gag gac gtt ttc cag aac gga ttc acg gcg tgg gga aac aac gac        192
Pro Glu Asp Val Phe Gln Asn Gly Phe Thr Ala Trp Gly Asn Asn Asp           
    50                  55                  60                            

aat gtg ctc gac cat ctg acc gga cgt tcc tgc cag gtc ggc agc agc        240
Asn Val Leu Asp His Leu Thr Gly Arg Ser Cys Gln Val Gly Ser Ser           
65                  70                  75                  80            

aac agc gct ttc gtc tcc acc agc agc agc cgg cgc tat acc gag gtc        288
Asn Ser Ala Phe Val Ser Thr Ser Ser Ser Arg Arg Tyr Thr Glu Val           
                85                  90                  95                

tat ctc gaa cat cgc atg cag gaa gcg gtc gag gcc gaa cgc gcc ggc        336
Tyr Leu Glu His Arg Met Gln Glu Ala Val Glu Ala Glu Arg Ala Gly           
            100                 105                 110                   

agg ggc acc ggc cac ttc atc ggc tac atc tac gaa gtc cgc gcc gac        384
Arg Gly Thr Gly His Phe Ile Gly Tyr Ile Tyr Glu Val Arg Ala Asp           
        115                 120                 125                       

aac aat ttc tac ggc gcc gcc agc tcg tac ttc gaa tac gtc gac act        432
Asn Asn Phe Tyr Gly Ala Ala Ser Ser Tyr Phe Glu Tyr Val Asp Thr           
    130                 135                 140                           

tat ggc gac aat gcc ggc cgt atc ctc gcc ggc gcg ctg gcc acc tac        480
Tyr Gly Asp Asn Ala Gly Arg Ile Leu Ala Gly Ala Leu Ala Thr Tyr           
145                 150                 155                 160           

cag agc gca tat ctg gca cac cgg cgc att ccg ccc gaa aac atc cgc        528
Gln Ser Ala Tyr Leu Ala His Arg Arg Ile Pro Pro Glu Asn Ile Arg           
                165                 170                 175               

agg gta acg cgg gtc tat cac aac ggc atc acc ggc gag acc acg acc        576
Arg Val Thr Arg Val Tyr His Asn Gly Ile Thr Gly Glu Thr Thr Thr           
            180                 185                 190                   

acg gag tat tcc aac gct cgc tac gtc agc cag cag act cgc gcc aat        624
Thr Glu Tyr Ser Asn Ala Arg Tyr Val Ser Gln Gln Thr Arg Ala Asn           
        195                 200                 205                       

ccc aac ccc tac aca tcg cga agg tcc gta gcg tcg atc gtc ggc aca        672
Pro Asn Pro Tyr Thr Ser Arg Arg Ser Val Ala Ser Ile Val Gly Thr           
    210                 215                 220                           

ttg gtg cgc atg gcg ccg gtg ata ggc gct tgc atg gcg cgg cag gcc        720
Leu Val Arg Met Ala Pro Val Ile Gly Ala Cys Met Ala Arg Gln Ala           
225                 230                 235                 240           

gaa agc tcc gag gcc atg gca gcc tgg tcc gaa cgc gcc ggc gag gcg        768
Glu Ser Ser Glu Ala Met Ala Ala Trp Ser Glu Arg Ala Gly Glu Ala           
                245                 250                 255               

atg gtt ctc gtg tac tac gaa agc atc gcg tat tcg ttc tagacctggc         817
Met Val Leu Val Tyr Tyr Glu Ser Ile Ala Tyr Ser Phe                       
            260                 265                                       

ccagccccgc ccaactccgg taattgaaca gc atg ccg atc gac cgc aag acg        870
                                    Met Pro Ile Asp Arg Lys Thr           
                                    270                 275               

ctc tgc cat ctc ctg tcc gtt ctg ccg ttg gcc ctc ctc gga tct cac        918
Leu Cys His Leu Leu Ser Val Leu Pro Leu Ala Leu Leu Gly Ser His           
            280                 285                 290                   

gtg gcg cgg gcc tcc acg cca ggc atc gtc att ccg ccg cag gaa cag        966
Val Ala Arg Ala Ser Thr Pro Gly Ile Val Ile Pro Pro Gln Glu Gln           
        295                 300                 305                       

att acc cag cat ggc agc ccc tat gga cgc tgc gcg aac aag acc cgt       1014
Ile Thr Gln His Gly Ser Pro Tyr Gly Arg Cys Ala Asn Lys Thr Arg           
    310                 315                 320                           

gcc ctg acc gtg gcg gaa ttg cgc ggc agc ggc gat ctg cag gag tac       1062
Ala Leu Thr Val Ala Glu Leu Arg Gly Ser Gly Asp Leu Gln Glu Tyr           
325                 330                 335                 340           

ctg cgt cat gtg acg cgc ggc tgg tca ata ttt gcg ctc tac gat ggc       1110
Leu Arg His Val Thr Arg Gly Trp Ser Ile Phe Ala Leu Tyr Asp Gly           
                345                 350                 355               

acc tat ctc ggc ggc gaa tat ggc ggc gtg atc aag gac gga aca ccc       1158
Thr Tyr Leu Gly Gly Glu Tyr Gly Gly Val Ile Lys Asp Gly Thr Pro           
            360                 365                 370                   

ggc ggc gca ttc gac ctg aaa acg acg ttc tgc atc atg acc acg cgc       1206
Gly Gly Ala Phe Asp Leu Lys Thr Thr Phe Cys Ile Met Thr Thr Arg           
        375                 380                 385                       

aat acg ggt caa ccc gca acg gat cac tac tac agc aac gtc acc gcc       1254
Asn Thr Gly Gln Pro Ala Thr Asp His Tyr Tyr Ser Asn Val Thr Ala           
    390                 395                 400                           

act cgc ctg ctc tcc agc acc aac agc agg cta tgc gcg gtc ttc gtc       1302
Thr Arg Leu Leu Ser Ser Thr Asn Ser Arg Leu Cys Ala Val Phe Val           
405                 410                 415                 420           

aga agc ggg caa ccg gtc att ggc gcc tgc acc agc ccg tat gac ggc       1350
Arg Ser Gly Gln Pro Val Ile Gly Ala Cys Thr Ser Pro Tyr Asp Gly           
                425                 430                 435               

aag tac tgg agc atg tac agc cgg ctg cgg aaa atg ctt tac ctg atc       1398
Lys Tyr Trp Ser Met Tyr Ser Arg Leu Arg Lys Met Leu Tyr Leu Ile           
            440                 445                 450                   

tac gtg gcc ggc atc tcc gta cgc gtc cat gtc agc aag gaa gaa cag       1446
Tyr Val Ala Gly Ile Ser Val Arg Val His Val Ser Lys Glu Glu Gln           
        455                 460                 465                       

tat tac gac tat gag gac gca acg ttc gag act tac gcc ctt acc ggc       1494
Tyr Tyr Asp Tyr Glu Asp Ala Thr Phe Glu Thr Tyr Ala Leu Thr Gly           
    470                 475                 480                           

atc tcc atc tgc aat cct gga tca tcc tta tgc tgagacgctt ccccactcga     1547
Ile Ser Ile Cys Asn Pro Gly Ser Ser Leu Cys                               
485                 490                 495                               

accaccgccc cgggacaggg cggcgcccgg cggtcgcgc gtg cgc gcc ctg gcg        1601
                                           Val Arg Ala Leu Ala            
                                                           500            

tgg ttg ctg gca tcc ggc gcg atg acg cat ctt tcc ccc gcc ctg gcc       1649
Trp Leu Leu Ala Ser Gly Ala Met Thr His Leu Ser Pro Ala Leu Ala           
                505                 510                 515               

gac gtt cct tat gtg ctg gtg aag acc aat atg gtg gtc acc agc gta       1697
Asp Val Pro Tyr Val Leu Val Lys Thr Asn Met Val Val Thr Ser Val           
            520                 525                 530                   

gcc atg aag ccg tat gaa gtc acc ccg acg cgc atg ctg gtc tgc ggc       1745
Ala Met Lys Pro Tyr Glu Val Thr Pro Thr Arg Met Leu Val Cys Gly           
        535                 540                 545                       

atc gcc gcc aaa ctg ggc gcc gcg gcc agc agc ccg gac gcg cac gtg       1793
Ile Ala Ala Lys Leu Gly Ala Ala Ala Ser Ser Pro Asp Ala His Val           
    550                 555                 560                           

ccg ttc tgc ttc ggc aag gat ctc aag cgt ccc ggc agc agt ccc atg       1841
Pro Phe Cys Phe Gly Lys Asp Leu Lys Arg Pro Gly Ser Ser Pro Met           
565                 570                 575                 580           

gaa gtc atg ttg cgc gcc gtc ttc atg caa caa cgg ccg ctg cgc atg       1889
Glu Val Met Leu Arg Ala Val Phe Met Gln Gln Arg Pro Leu Arg Met           
                585                 590                 595               

ttt ctg ggt ccc aag caa ctc act ttc gaa ggc aag ccc gcg ctc gaa       1937
Phe Leu Gly Pro Lys Gln Leu Thr Phe Glu Gly Lys Pro Ala Leu Glu           
            600                 605                 610                   

ctg atc cgg atg gtc gaa tgc agc ggc aag cag gat tgc ccc               1979
Leu Ile Arg Met Val Glu Cys Ser Gly Lys Gln Asp Cys Pro                   
        615                 620                 625                       

tgaaggcgaa cccc atg cat acc atc gca tcc atc ctg ttg tcc gtg ctc       2029
                Met His Thr Ile Ala Ser Ile Leu Leu Ser Val Leu           
                            630                 635                       

ggc ata tac agc ccg gct gac gtc gcc ggc ttg ccg acc cat ctg tac       2077
Gly Ile Tyr Ser Pro Ala Asp Val Ala Gly Leu Pro Thr His Leu Tyr           
    640                 645                 650                           

aag aac ttc act gtc cag gag ctg gcc ttg aaa ctg aag ggc aag aat       2125
Lys Asn Phe Thr Val Gln Glu Leu Ala Leu Lys Leu Lys Gly Lys Asn           
655                 660                 665                 670           

cag gag ttc tgc ctg acc gcc ttc atg tcg ggc aga agc ctg gtc cgg       2173
Gln Glu Phe Cys Leu Thr Ala Phe Met Ser Gly Arg Ser Leu Val Arg           
                675                 680                 685               

gcg tgc ctg tcc gac gcg gga cac gag cac gac acg tgg ttc gac acc       2221
Ala Cys Leu Ser Asp Ala Gly His Glu His Asp Thr Trp Phe Asp Thr           
            690                 695                 700                   

atg ctt ggc ttt gcc ata tcc gcg tat gcg ctc aag agc cgg atc gcg       2269
Met Leu Gly Phe Ala Ile Ser Ala Tyr Ala Leu Lys Ser Arg Ile Ala           
        705                 710                 715                       

ctg acg gtg gaa gac tcg ccg tat ccg ggc act ccc ggc gat ctg ctc       2317
Leu Thr Val Glu Asp Ser Pro Tyr Pro Gly Thr Pro Gly Asp Leu Leu           
    720                 725                 730                           

gaa ctg cag atc tgc ccg ctc aac gga tat tgc gaa tgaacccttc            2363
Glu Leu Gln Ile Cys Pro Leu Asn Gly Tyr Cys Glu                           
735                 740                 745                               

cggaggtttc gacgtttccg cgcaatccgc ttgagacgat cttccgccct ggttccattc     2423

cgggaacacc gcaac atg ctg atc aac aac aag aag ctg ctt cat cac att      2474
                 Met Leu Ile Asn Asn Lys Lys Leu Leu His His Ile          
                             750                 755                      

ctg ccc atc ctg gtg ctc gcc ctg ctg ggc atg cgc acg gcc cag gcc       2522
Leu Pro Ile Leu Val Leu Ala Leu Leu Gly Met Arg Thr Ala Gln Ala           
    760                 765                 770                           

gtt gcg cca ggc atc gtc atc ccg ccg aag gca ctg ttc acc caa cag       2570
Val Ala Pro Gly Ile Val Ile Pro Pro Lys Ala Leu Phe Thr Gln Gln           
775                 780                 785                 790           

ggc ggc gcc tat gga cgc tgc ccg aac gga acc cgc gcc ttg acc gtg       2618
Gly Gly Ala Tyr Gly Arg Cys Pro Asn Gly Thr Arg Ala Leu Thr Val           
                795                 800                 805               

gcc gaa ctg cgc ggc aac gcc gaa ttg cag acg tat ttg cgc cag ata       2666
Ala Glu Leu Arg Gly Asn Ala Glu Leu Gln Thr Tyr Leu Arg Gln Ile           
            810                 815                 820                   

acg ccc ggc tgg tcc ata tac ggt ctc tat gac ggt acg tac ctg ggc       2714
Thr Pro Gly Trp Ser Ile Tyr Gly Leu Tyr Asp Gly Thr Tyr Leu Gly           
        825                 830                 835                       

cag gcg tac ggc ggc atc atc aag gac gcg ccg cca ggc gcg ggg ttc       2762
Gln Ala Tyr Gly Gly Ile Ile Lys Asp Ala Pro Pro Gly Ala Gly Phe           
    840                 845                 850                           

att tat cgc gaa act ttc tgc atc acg acc ata tac aag acc ggg caa       2810
Ile Tyr Arg Glu Thr Phe Cys Ile Thr Thr Ile Tyr Lys Thr Gly Gln           
855                 860                 865                 870           

ccg gct gcg gat cac tac tac agc aag gtc acg gcc acg cgc ctg ctc       2858
Pro Ala Ala Asp His Tyr Tyr Ser Lys Val Thr Ala Thr Arg Leu Leu           
                875                 880                 885               

gcc agc acc aac agc agg ctg tgc gcg gta ttc gtc agg gac ggg caa       2906
Ala Ser Thr Asn Ser Arg Leu Cys Ala Val Phe Val Arg Asp Gly Gln           
            890                 895                 900                   

tcg gtc atc gga gcc tgc gcc agc ccg tat gaa ggc agg tac aga gac       2954
Ser Val Ile Gly Ala Cys Ala Ser Pro Tyr Glu Gly Arg Tyr Arg Asp           
        905                 910                 915                       

atg tac gac gcg ctg cgg cgc ctg ctg tac atg atc tat atg tcc ggc       3002
Met Tyr Asp Ala Leu Arg Arg Leu Leu Tyr Met Ile Tyr Met Ser Gly           
    920                 925                 930                           

ctt gcc gta cgc gtc cac gtc agc aag gag gaa cag tat tac gac tac       3050
Leu Ala Val Arg Val His Val Ser Lys Glu Glu Gln Tyr Tyr Asp Tyr           
935                 940                 945                 950           

gag gac gcc aca ttc cag acc tat gcc ctc acc ggc att tcc ctc tgc       3098
Glu Asp Ala Thr Phe Gln Thr Tyr Ala Leu Thr Gly Ile Ser Leu Cys           
                955                 960                 965               

aac ccg gca gcg tcg ata tgc                                           3119
Asn Pro Ala Ala Ser Ile Cys                                               
            970                                                           


<210> 25
<211> 269
<212> PRT
<213> Bordetella pertussis

<400> 25
Met Arg Cys Thr Arg Ala Ile Arg Gln Thr Ala Arg Thr Gly Trp Leu 
1               5                   10                  15      


Thr Trp Leu Ala Ile Leu Ala Val Thr Ala Pro Val Thr Ser Pro Ala 
            20                  25                  30          


Trp Ala Asp Asp Pro Pro Ala Thr Val Tyr Lys Tyr Asp Ser Arg Pro 
        35                  40                  45              


Pro Glu Asp Val Phe Gln Asn Gly Phe Thr Ala Trp Gly Asn Asn Asp 
    50                  55                  60                  


Asn Val Leu Asp His Leu Thr Gly Arg Ser Cys Gln Val Gly Ser Ser 
65                  70                  75                  80  


Asn Ser Ala Phe Val Ser Thr Ser Ser Ser Arg Arg Tyr Thr Glu Val 
                85                  90                  95      


Tyr Leu Glu His Arg Met Gln Glu Ala Val Glu Ala Glu Arg Ala Gly 
            100                 105                 110         


Arg Gly Thr Gly His Phe Ile Gly Tyr Ile Tyr Glu Val Arg Ala Asp 
        115                 120                 125             


Asn Asn Phe Tyr Gly Ala Ala Ser Ser Tyr Phe Glu Tyr Val Asp Thr 
    130                 135                 140                 


Tyr Gly Asp Asn Ala Gly Arg Ile Leu Ala Gly Ala Leu Ala Thr Tyr 
145                 150                 155                 160 


Gln Ser Ala Tyr Leu Ala His Arg Arg Ile Pro Pro Glu Asn Ile Arg 
                165                 170                 175     


Arg Val Thr Arg Val Tyr His Asn Gly Ile Thr Gly Glu Thr Thr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Asn Ala Arg Tyr Val Ser Gln Gln Thr Arg Ala Asn 
        195                 200                 205             


Pro Asn Pro Tyr Thr Ser Arg Arg Ser Val Ala Ser Ile Val Gly Thr 
    210                 215                 220                 


Leu Val Arg Met Ala Pro Val Ile Gly Ala Cys Met Ala Arg Gln Ala 
225                 230                 235                 240 


Glu Ser Ser Glu Ala Met Ala Ala Trp Ser Glu Arg Ala Gly Glu Ala 
                245                 250                 255     


Met Val Leu Val Tyr Tyr Glu Ser Ile Ala Tyr Ser Phe 
            260                 265                 


<210> 26
<211> 226
<212> PRT
<213> Bordetella pertussis

<400> 26
Met Pro Ile Asp Arg Lys Thr Leu Cys His Leu Leu Ser Val Leu Pro 
1               5                   10                  15      


Leu Ala Leu Leu Gly Ser His Val Ala Arg Ala Ser Thr Pro Gly Ile 
            20                  25                  30          


Val Ile Pro Pro Gln Glu Gln Ile Thr Gln His Gly Ser Pro Tyr Gly 
        35                  40                  45              


Arg Cys Ala Asn Lys Thr Arg Ala Leu Thr Val Ala Glu Leu Arg Gly 
    50                  55                  60                  


Ser Gly Asp Leu Gln Glu Tyr Leu Arg His Val Thr Arg Gly Trp Ser 
65                  70                  75                  80  


Ile Phe Ala Leu Tyr Asp Gly Thr Tyr Leu Gly Gly Glu Tyr Gly Gly 
                85                  90                  95      


Val Ile Lys Asp Gly Thr Pro Gly Gly Ala Phe Asp Leu Lys Thr Thr 
            100                 105                 110         


Phe Cys Ile Met Thr Thr Arg Asn Thr Gly Gln Pro Ala Thr Asp His 
        115                 120                 125             


Tyr Tyr Ser Asn Val Thr Ala Thr Arg Leu Leu Ser Ser Thr Asn Ser 
    130                 135                 140                 


Arg Leu Cys Ala Val Phe Val Arg Ser Gly Gln Pro Val Ile Gly Ala 
145                 150                 155                 160 


Cys Thr Ser Pro Tyr Asp Gly Lys Tyr Trp Ser Met Tyr Ser Arg Leu 
                165                 170                 175     


Arg Lys Met Leu Tyr Leu Ile Tyr Val Ala Gly Ile Ser Val Arg Val 
            180                 185                 190         


His Val Ser Lys Glu Glu Gln Tyr Tyr Asp Tyr Glu Asp Ala Thr Phe 
        195                 200                 205             


Glu Thr Tyr Ala Leu Thr Gly Ile Ser Ile Cys Asn Pro Gly Ser Ser 
    210                 215                 220                 


Leu Cys 
225     


<210> 27
<211> 227
<212> PRT
<213> Bordetella pertussis

<400> 27
Met Leu Ile Asn Asn Lys Lys Leu Leu His His Ile Leu Pro Ile Leu 
1               5                   10                  15      


Val Leu Ala Leu Leu Gly Met Arg Thr Ala Gln Ala Val Ala Pro Gly 
            20                  25                  30          


Ile Val Ile Pro Pro Lys Ala Leu Phe Thr Gln Gln Gly Gly Ala Tyr 
        35                  40                  45              


Gly Arg Cys Pro Asn Gly Thr Arg Ala Leu Thr Val Ala Glu Leu Arg 
    50                  55                  60                  


Gly Asn Ala Glu Leu Gln Thr Tyr Leu Arg Gln Ile Thr Pro Gly Trp 
65                  70                  75                  80  


Ser Ile Tyr Gly Leu Tyr Asp Gly Thr Tyr Leu Gly Gln Ala Tyr Gly 
                85                  90                  95      


Gly Ile Ile Lys Asp Ala Pro Pro Gly Ala Gly Phe Ile Tyr Arg Glu 
            100                 105                 110         


Thr Phe Cys Ile Thr Thr Ile Tyr Lys Thr Gly Gln Pro Ala Ala Asp 
        115                 120                 125             


His Tyr Tyr Ser Lys Val Thr Ala Thr Arg Leu Leu Ala Ser Thr Asn 
    130                 135                 140                 


Ser Arg Leu Cys Ala Val Phe Val Arg Asp Gly Gln Ser Val Ile Gly 
145                 150                 155                 160 


Ala Cys Ala Ser Pro Tyr Glu Gly Arg Tyr Arg Asp Met Tyr Asp Ala 
                165                 170                 175     


Leu Arg Arg Leu Leu Tyr Met Ile Tyr Met Ser Gly Leu Ala Val Arg 
            180                 185                 190         


Val His Val Ser Lys Glu Glu Gln Tyr Tyr Asp Tyr Glu Asp Ala Thr 
        195                 200                 205             


Phe Gln Thr Tyr Ala Leu Thr Gly Ile Ser Leu Cys Asn Pro Ala Ala 
    210                 215                 220                 


Ser Ile Cys 
225         


<210> 28
<211> 131
<212> PRT
<213> Bordetella pertussis

<400> 28
Val Arg Ala Leu Ala Trp Leu Leu Ala Ser Gly Ala Met Thr His Leu 
1               5                   10                  15      


Ser Pro Ala Leu Ala Asp Val Pro Tyr Val Leu Val Lys Thr Asn Met 
            20                  25                  30          


Val Val Thr Ser Val Ala Met Lys Pro Tyr Glu Val Thr Pro Thr Arg 
        35                  40                  45              


Met Leu Val Cys Gly Ile Ala Ala Lys Leu Gly Ala Ala Ala Ser Ser 
    50                  55                  60                  


Pro Asp Ala His Val Pro Phe Cys Phe Gly Lys Asp Leu Lys Arg Pro 
65                  70                  75                  80  


Gly Ser Ser Pro Met Glu Val Met Leu Arg Ala Val Phe Met Gln Gln 
                85                  90                  95      


Arg Pro Leu Arg Met Phe Leu Gly Pro Lys Gln Leu Thr Phe Glu Gly 
            100                 105                 110         


Lys Pro Ala Leu Glu Leu Ile Arg Met Val Glu Cys Ser Gly Lys Gln 
        115                 120                 125             


Asp Cys Pro 
    130     


<210> 29
<211> 120
<212> PRT
<213> Bordetella pertussis

<400> 29
Met His Thr Ile Ala Ser Ile Leu Leu Ser Val Leu Gly Ile Tyr Ser 
1               5                   10                  15      


Pro Ala Asp Val Ala Gly Leu Pro Thr His Leu Tyr Lys Asn Phe Thr 
            20                  25                  30          


Val Gln Glu Leu Ala Leu Lys Leu Lys Gly Lys Asn Gln Glu Phe Cys 
        35                  40                  45              


Leu Thr Ala Phe Met Ser Gly Arg Ser Leu Val Arg Ala Cys Leu Ser 
    50                  55                  60                  


Asp Ala Gly His Glu His Asp Thr Trp Phe Asp Thr Met Leu Gly Phe 
65                  70                  75                  80  


Ala Ile Ser Ala Tyr Ala Leu Lys Ser Arg Ile Ala Leu Thr Val Glu 
                85                  90                  95      


Asp Ser Pro Tyr Pro Gly Thr Pro Gly Asp Leu Leu Glu Leu Gln Ile 
            100                 105                 110         


Cys Pro Leu Asn Gly Tyr Cys Glu 
        115                 120 


<210> 30
<211> 451
<212> PRT
<213> Clostridium tetani

<400> 30
Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile 
1               5                   10                  15      


Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile 
            20                  25                  30          


Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala 
        35                  40                  45              


Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn 
    50                  55                  60                  


Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn 
65                  70                  75                  80  


Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
                85                  90                  95      


Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile 
            100                 105                 110         


Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser 
        115                 120                 125             


Val Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala 
    130                 135                 140                 


Gly Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe Asn 
145                 150                 155                 160 


Ala Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg 
                165                 170                 175     


Leu Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala 
            180                 185                 190         


Glu Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu 
        195                 200                 205             


Lys Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys 
    210                 215                 220                 


Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn 
                245                 250                 255     


Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser Ser 
            260                 265                 270         


Ser Lys Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu Thr 
        275                 280                 285             


Asn Ala Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg Arg 
    290                 295                 300                 


Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn 
305                 310                 315                 320 


Glu Ile Asp Ser Phe Val Lys Ser Gly Asp Phe Ile Lys Leu Tyr Val 
                325                 330                 335     


Ser Tyr Asn Asn Asn Glu His Ile Val Gly Tyr Pro Lys Asp Gly Asn 
            340                 345                 350         


Ala Phe Asn Asn Leu Asp Arg Ile Leu Arg Val Gly Tyr Asn Ala Pro 
        355                 360                 365             


Gly Ile Pro Leu Tyr Lys Lys Met Glu Ala Val Lys Leu Arg Asp Leu 
    370                 375                 380                 


Lys Thr Tyr Ser Val Gln Leu Lys Leu Tyr Asp Asp Lys Asn Ala Ser 
385                 390                 395                 400 


Leu Gly Leu Val Gly Thr His Asn Gly Gln Ile Gly Asn Asp Pro Asn 
                405                 410                 415     


Arg Asp Ile Leu Ile Ala Ser Asn Trp Tyr Phe Asn His Leu Lys Asp 
            420                 425                 430         


Lys Ile Leu Gly Cys Asp Trp Tyr Phe Val Pro Thr Asp Glu Gly Trp 
        435                 440                 445             


Thr Asn Asp 
    450     


<210> 31
<211> 1353
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(1353)

<400> 31
aaa aac ctg gac tgt tgg gtt gac aac gaa gaa gat atc gat gtc atc         48
Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile           
1               5                   10                  15                

ctg aag aaa tcc acc att ttg aac ctc gac atc aac aat gac atc att         96
Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile           
            20                  25                  30                    

tcc gac att agc ggt ttc aac tcg tcc gtg att acg tac cca gat gct        144
Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala           
        35                  40                  45                        

cag ctg gtg ccc ggg att aac ggc aag gct atc cac ctc gtc aac aac        192
Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn           
    50                  55                  60                            

gag tcg tcg gaa gtc atc gtc cat aaa gcg atg gac atc gag tat aac        240
Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn           
65                  70                  75                  80            

gac atg ttt aat aat ttc acc gtg tcc ttt tgg ctg cgc gtg ccc aag        288
Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys           
                85                  90                  95                

gtg tcc gcc tcc cac ctg gaa cag tac ggg acc aac gag tac agc atc        336
Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile           
            100                 105                 110                   

atc agc tcg atg aag aag cac tcg ttg agc atc ggc agc ggc tgg tcg        384
Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser           
        115                 120                 125                       

gtt agt ctc aaa ggg aac aac ctg att tgg acc ctg aaa gat agc gcc        432
Val Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala           
    130                 135                 140                           

ggc gag gtg cgt cag atc act ttc cgg gac ctg ccg gat aag ttc aac        480
Gly Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe Asn           
145                 150                 155                 160           

gcc tac ctg gca aac aaa tgg gtg ttc att acc atc acg aac gac cgc        528
Ala Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg           
                165                 170                 175               

ctg agt agc gcg aat ctc tac atc aat ggc gtg ctg atg ggc agc gcg        576
Leu Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala           
            180                 185                 190                   

gaa atc acg ggc ttg ggt gcc atc cgc gaa gat aac aat atc acc ttg        624
Glu Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu           
        195                 200                 205                       

aag ctg gac cgc tgc aac aac aac aac caa tac gtg tcc att gat aag        672
Lys Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys           
    210                 215                 220                           

ttc cgc atc ttt tgc aag gcc ctg aac ccg aaa gag atc gaa aag ctc        720
Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu           
225                 230                 235                 240           

tac acc agc tac ttg agt atc acc ttc ctg cgc gac ttt tgg ggt aat        768
Tyr Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn           
                245                 250                 255               

ccg ttg cgt tat gac acc gag tat tat ctg atc ccc gtg gcc agc agc        816
Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser Ser           
            260                 265                 270                   

agc aag gac gtc cag ctg aag aac atc acc gac tac atg tac ttg act        864
Ser Lys Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu Thr           
        275                 280                 285                       

aac gcg ccc tcg tat acc aat ggc aaa ctg aac att tac tac cgc cgg        912
Asn Ala Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg Arg           
    290                 295                 300                           

ctc tac aac ggg ctc aag ttc atc atc aaa cgc tat acg ccg aat aat        960
Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn           
305                 310                 315                 320           

gaa atc gac agt ttt gtc aag agc ggc gac ttc atc aag ttg tac gtg       1008
Glu Ile Asp Ser Phe Val Lys Ser Gly Asp Phe Ile Lys Leu Tyr Val           
                325                 330                 335               

agc tac aat aac aac gag cac atc gtt ggt tac cct aag gat ggc aac       1056
Ser Tyr Asn Asn Asn Glu His Ile Val Gly Tyr Pro Lys Asp Gly Asn           
            340                 345                 350                   

gct ttc aac aac ctc gat cgt atc ctg cgg gtt ggc tac aac gca cca       1104
Ala Phe Asn Asn Leu Asp Arg Ile Leu Arg Val Gly Tyr Asn Ala Pro           
        355                 360                 365                       

ggc att ccg ctg tat aag aag atg gaa gcg gtc aaa ctg cgt gac ctg       1152
Gly Ile Pro Leu Tyr Lys Lys Met Glu Ala Val Lys Leu Arg Asp Leu           
    370                 375                 380                           

aaa acc tac tcc gtg caa ctg aag ctg tac gac gac aag aat gcc tcg       1200
Lys Thr Tyr Ser Val Gln Leu Lys Leu Tyr Asp Asp Lys Asn Ala Ser           
385                 390                 395                 400           

ttg ggt ctg gtc ggc acg cat aat ggt cag att ggc aac gac ccg aac       1248
Leu Gly Leu Val Gly Thr His Asn Gly Gln Ile Gly Asn Asp Pro Asn           
                405                 410                 415               

cgg gac atc ctg atc gcc agc aac tgg tat ttc aat cac ctg aag gat       1296
Arg Asp Ile Leu Ile Ala Ser Asn Trp Tyr Phe Asn His Leu Lys Asp           
            420                 425                 430                   

aag atc ttg ggc tgc gat tgg tat ttc gtc cct acc gat gag ggc tgg       1344
Lys Ile Leu Gly Cys Asp Trp Tyr Phe Val Pro Thr Asp Glu Gly Trp           
        435                 440                 445                       

act aat gac                                                           1353
Thr Asn Asp                                                               
    450                                                                   


<210> 32
<211> 2366
<212> PRT
<213> Clostridium difficile

<400> 32
Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210> 33
<211> 7098
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(7098)

<400> 33
atg tcc ctc gtc aat cgc aag cag ctg gag aag atg gcc aac gtt cgt         48
Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg           
1               5                   10                  15                

ttc cgc acc caa gag gac gaa tac gtc gcc atc ctc gac gcc ctg gaa         96
Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu           
            20                  25                  30                    

gaa tac cat aac atg agc gaa aac acc gtt gtc gag aag tac ctc aag        144
Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys           
        35                  40                  45                        

ctg aag gac atc aac agc ctg acg gac atc tat atc gac acg tac aag        192
Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys           
    50                  55                  60                            

aag tcc ggt cgc aac aag gca ctc aag aag ttc aaa gag tac ctg gtc        240
Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val           
65                  70                  75                  80            

acc gaa gtg ttg gaa ctc aag aac aac aac ctc acg ccg gtg gaa aag        288
Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys           
                85                  90                  95                

aac ctg cat ttc gtg tgg att ggc ggc cag atc aac gac acc gcc atc        336
Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile           
            100                 105                 110                   

aac tac att aac cag tgg aaa gac gtc aac tcg gac tac aat gtg aat        384
Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn           
        115                 120                 125                       

gtg ttc tat gac tcg aac gcc ttt ttg atc aac acg ctg aag aaa acc        432
Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr           
    130                 135                 140                           

gtc gtg gaa tcg gcc atc aat gac acc ctg gaa agc ttc cgt gaa aac        480
Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn           
145                 150                 155                 160           

ctc aac gat cct cgg ttt gac tac aac aag ttt ttc cgc aag cgc atg        528
Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met           
                165                 170                 175               

gag atc atc tat gac aag cag aaa aac ttt atc aac tac tac aaa gcg        576
Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala           
            180                 185                 190                   

cag cgc gaa gag aac ccg gag ctg atc atc gac gat atc gtg aaa acc        624
Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr           
        195                 200                 205                       

tat ctg tcc aac gag tat agt aaa gaa atc gat gag ctg aac acg tat        672
Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr           
    210                 215                 220                           

atc gaa gag agt ctg aac aag atc act cag aac agc ggt aac gac gtc        720
Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val           
225                 230                 235                 240           

cgg aac ttt gaa gag ttc aaa aac ggc gag tcg ttc aac ctc tac gaa        768
Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu           
                245                 250                 255               

cag gag ctg gtc gag cgc tgg aac ctg gca gcg gcg tcg gac atc ctg        816
Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu           
            260                 265                 270                   

cgt atc agc gct ctg aaa gag atc ggc ggc atg tac ctg gac gtg gat        864
Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp           
        275                 280                 285                       

atg ctc cct ggc atc cag cct gat ctg ttt gaa tcg att gaa aag cca        912
Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro           
    290                 295                 300                           

tcg agc gtg acc gtc gac ttt tgg gag atg acc aag ctg gag gcg atc        960
Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile           
305                 310                 315                 320           

atg aag tac aaa gaa tac atc ccg gag tat acg agt gaa cac ttt gat       1008
Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp           
                325                 330                 335               

atg ctg gac gaa gaa gtg caa tcc tcg ttt gaa agc gtc ctg gcg agc       1056
Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser           
            340                 345                 350                   

aag agt gat aag agc gaa atc ttc tcg tcc ttg ggc gat atg gag gcg       1104
Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala           
        355                 360                 365                       

tcc cca ctg gag gtc aaa atc gcc ttc aac agc aag ggc att atc aat       1152
Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn           
    370                 375                 380                           

cag ggc ctg att tcg gtc aag gat agc tac tgc agc aac ctg atc gtc       1200
Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val           
385                 390                 395                 400           

aag cag atc gag aac cgt tac aag atc ctg aac aac agt ctg aac ccc       1248
Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro           
                405                 410                 415               

gcc atc agc gaa gat aat gac ttc aat acc acg acg aac acg ttt atc       1296
Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile           
            420                 425                 430                   

gac tcc atc atg gcc gaa gcc aac gcg gac aac ggc cgc ttt atg atg       1344
Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met           
        435                 440                 445                       

gag ttg ggg aag tac ctg cgc gtg ggc ttc ttc ccg gac gtg aaa acc       1392
Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr           
    450                 455                 460                           

acg atc aat ctc tcc ggc cca gaa gcg tat gca gcc gca tac caa gat       1440
Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp           
465                 470                 475                 480           

ctg ctc atg ttc aaa gag ggc tcg atg aac atc cat ctg att gag gcg       1488
Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala           
                485                 490                 495               

gac ttg cgc aac ttc gaa atc tcg aaa acg aac atc agc caa tcg acg       1536
Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr           
            500                 505                 510                   

gag cag gaa atg gcg agc ctg tgg tcc ttc gac gat gct cgc gcc aag       1584
Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys           
        515                 520                 525                       

gcc caa ttt gaa gag tac aaa cgg aac tac ttc gaa ggc tcg ctg ggt       1632
Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly           
    530                 535                 540                           

gag gat gac aac ttg gac ttc tcg caa aac atc gtc gtg gac aaa gaa       1680
Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu           
545                 550                 555                 560           

tac ctg ttg gaa aag atc agc tcc ctg gcc cgg agc tcg gaa cgg ggc       1728
Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly           
                565                 570                 575               

tac atc cac tac att gtt cag ctg caa ggg gat aag atc tcg tat gaa       1776
Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu           
            580                 585                 590                   

gcg gcg tgc aat ctc ttc gcc aag acg ccg tac gac tcc gtg ctg ttc       1824
Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe           
        595                 600                 605                       

cag aag aac atc gag gac agt gaa atc gcc tac tat tac aac ccc ggt       1872
Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly           
    610                 615                 620                           

gac ggc gaa atc caa gaa att gat aag tac aag atc ccg tcc att atc       1920
Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile           
625                 630                 635                 640           

tcc gat cgt ccg aag atc aaa ctc acc ttc att ggc cac ggg aag gac       1968
Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp           
                645                 650                 655               

gag ttc aac acc gat atc ttc gca ggt ttt gac gtg gat agt ctc tcg       2016
Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser           
            660                 665                 670                   

acc gag atc gag gcc gcg atc gac ctg gcg aaa gag gac att tcg cca       2064
Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro           
        675                 680                 685                       

aag tcg atc gaa atc aac ctg ctg ggc tgc aat atg ttt tcg tat agt       2112
Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser           
    690                 695                 700                           

atc aac gtt gaa gaa acc tat ccg ggc aaa ctc ctg ctg aag gtc aag       2160
Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys           
705                 710                 715                 720           

gac aag att agc gaa ctg atg ccg agc atc tcg cag gat agc atc atc       2208
Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile           
                725                 730                 735               

gtg agt gct aac cag tat gag gtg cgt atc aac agc gag ggt cgc cgc       2256
Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg           
            740                 745                 750                   

gag ctg ctc gat cac tcg ggc gag tgg atc aac aaa gaa gag agc atc       2304
Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile           
        755                 760                 765                       

atc aaa gat atc agc agt aaa gaa tac att agt ttc aac ccg aaa gag       2352
Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu           
    770                 775                 780                           

aac aag atc acg gtg aaa tcg aag aat ttg ccg gag ttg agt acc ctg       2400
Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu           
785                 790                 795                 800           

ctg cag gag atc cgt aac aat tcc aac tcc agt gat atc gaa ctc gaa       2448
Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu           
                805                 810                 815               

gaa aag gtc atg ctg acc gag tgc gag atc aat gtc atc agc aac atc       2496
Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile           
            820                 825                 830                   

gac act cag atc gtg gaa gaa cgc att gaa gag gcc aag aac ctg acc       2544
Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr           
        835                 840                 845                       

tcg gac tcg atc aac tat atc aaa gac gag ttc aag ctg att gaa tcc       2592
Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser           
    850                 855                 860                           

atc tcg gat gcc ctg tgc gac ctg aag cag cag aac gag ttg gag gat       2640
Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp           
865                 870                 875                 880           

agc cac ttc atc agt ttc gag gat atc tcg gag act gac gag ggc ttc       2688
Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe           
                885                 890                 895               

agc atc cgt ttc atc aac aaa gaa acc ggt gaa tcc att ttc gtt gaa       2736
Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu           
            900                 905                 910                   

acg gag aaa acc att ttc agc gaa tac gcc aat cac atc acc gaa gag       2784
Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu           
        915                 920                 925                       

atc agc aag atc aag ggt act atc ttt gac acg gtg aat ggc aaa ctg       2832
Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu           
    930                 935                 940                           

gtg aag aaa gtc aac ctg gac acc acc cac gag gtc aac acc ctg aac       2880
Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn           
945                 950                 955                 960           

gcc gcg ttc ttc atc caa agc ctg atc gaa tac aac agc tcc aaa gaa       2928
Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu           
                965                 970                 975               

tcc ttg agc aac ttg agc gtg gcc atg aaa gtg cag gtg tat gcc cag       2976
Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln           
            980                 985                 990                   

ttg ttc tcg acc ggc ctg aac acc  att acg gac gcg gca  aag gtg gtt     3024
Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val         
        995                 1000                 1005                     

gaa ctg  gtc agc acc gcc ttg  gac gaa acc atc gac  ctg ctg ccg        3069
Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro            
    1010                 1015                 1020                        

acc ctg  agc gag ggc ctg ccc  atc atc gcc acg atc  att gac ggg        3114
Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly            
    1025                 1030                 1035                        

gtc agc  ctg ggc gca gcc atc  aaa gag ttg agc gag  act tcc gac        3159
Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp            
    1040                 1045                 1050                        

ccg ctg  ctg cgc cag gaa atc  gaa gct aag atc ggg  atc atg gcc        3204
Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala            
    1055                 1060                 1065                        

gtg aat  ctg acc acc gcg acc  acc gcg atc att acc  tcc agc ctc        3249
Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu            
    1070                 1075                 1080                        

ggc att  gcg tcc ggc ttc tcc  atc ctg ctg gtc ccc  ttg gcg ggc        3294
Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly            
    1085                 1090                 1095                        

atc agc  gcc ggt atc cct agc  ttg gtg aac aac gag  ttg gtc ctg        3339
Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu            
    1100                 1105                 1110                        

cgt gat  aaa gcg acc aag gtt  gtg gat tac ttc aag  cat gtc tcc        3384
Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser            
    1115                 1120                 1125                        

ctg gtc  gaa acg gaa ggg gtg  ttc acc ctg ctg gac  gat aag att        3429
Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile            
    1130                 1135                 1140                        

atg atg  ccc caa gac gat ttg  gtc atc agc gaa att  gac ttt aac        3474
Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn            
    1145                 1150                 1155                        

aac aat  tcg atc gtc ctc ggg  aag tgt gaa atc tgg  cgg atg gag        3519
Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu            
    1160                 1165                 1170                        

ggc ggt  tcg ggc cac acc gtg  acc gat gat atc gac  cat ttc ttt        3564
Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe            
    1175                 1180                 1185                        

agt gcg  ccc tcc atc acg tac  cgc gag ccg cac ctg  agc atc tac        3609
Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr            
    1190                 1195                 1200                        

gac gtg  ctc gag gtg cag aaa  gaa gaa ctg gat ctg  tcc aaa gat        3654
Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp            
    1205                 1210                 1215                        

ctg atg  gtt ctg ccg aac gct  ccc aat cgg gtg ttc  gct tgg gaa        3699
Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu            
    1220                 1225                 1230                        

acg ggc  tgg acg cca ggc ctc  cgc tcg ctg gag aac  gac ggg act        3744
Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr            
    1235                 1240                 1245                        

aag ttg  ctg gat cgc att cgc  gac aat tac gaa ggc  gaa ttc tac        3789
Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr            
    1250                 1255                 1260                        

tgg cgc  tac ttt gcg ttt atc  gcc gac gct ctg att  acc acc ctg        3834
Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu            
    1265                 1270                 1275                        

aag ccg  cgg tac gag gac act  aac atc cgc atc aat  ctg gat agc        3879
Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser            
    1280                 1285                 1290                        

aac act  cgc agc ttc att gtc  ccg atc atc acc act  gaa tac att        3924
Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile            
    1295                 1300                 1305                        

cgc gaa  aag ctg agc tac agc  ttt tac ggt agc ggt  ggt acc tat        3969
Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr            
    1310                 1315                 1320                        

gcc ctg  agc ctg tcc cag tac  aac atg ggc atc aac  att gaa ttg        4014
Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu            
    1325                 1330                 1335                        

tcg gag  agc gat gtg tgg atc  att gac gtg gat aat  gtc gtc cgc        4059
Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg            
    1340                 1345                 1350                        

gat gtg  acc att gag agc gac  aaa atc aag aaa ggg  gat ttg atc        4104
Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile            
    1355                 1360                 1365                        

gaa ggc  atc ctg tcg acc ttg  agc atc gaa gag aat  aag atc atc        4149
Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile            
    1370                 1375                 1380                        

ctg aat  agc cac gaa atc aac  ttc tcc ggc gaa gtg  aac ggc agc        4194
Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser            
    1385                 1390                 1395                        

aac ggc  ttc gtc agc ctg acc  ttt tcc atc ctg gaa  ggt atc aac        4239
Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn            
    1400                 1405                 1410                        

gcc atc  att gag gtc gat ctg  ctc agc aaa agc tac  aag ctg ctc        4284
Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu            
    1415                 1420                 1425                        

atc tcg  ggc gag ctg aaa atc  ctc atg ttg aat tcg  aat cac atc        4329
Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile            
    1430                 1435                 1440                        

caa cag  aaa atc gac tat atc  ggc ttc aac agc gag  ctg caa aag        4374
Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys            
    1445                 1450                 1455                        

aac atc  ccc tac tcg ttt gtg  gac agc gaa ggc aaa  gag aac ggc        4419
Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly            
    1460                 1465                 1470                        

ttc atc  aac ggc tcc acc aaa  gag ggg ctg ttc gtg  agc gag ctg        4464
Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu            
    1475                 1480                 1485                        

ccg gac  gtg gtg ctc atc agc  aaa gtg tat atg gac  gac agc aag        4509
Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys            
    1490                 1495                 1500                        

cct agt  ttt ggc tac tac tcc  aat aac ctg aaa gat  gtt aaa gtg        4554
Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val            
    1505                 1510                 1515                        

att acc  aag gat aac gtg aac  atc ctc acc ggt tac  tac ctg aag        4599
Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys            
    1520                 1525                 1530                        

gac gac  att aag atc agc ctg  tcc ctg acc ctg caa  gat gaa aag        4644
Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys            
    1535                 1540                 1545                        

acc atc  aaa ttg aat agc gtc  cat ctc gac gag agt  ggt gtc gcc        4689
Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala            
    1550                 1555                 1560                        

gag atc  ttg aag ttc atg aat  cgc aag ggt aat acc  aac acg agc        4734
Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser            
    1565                 1570                 1575                        

gac tcg  ttg atg tcc ttc ctg  gaa agc atg aac atc  aag agc att        4779
Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile            
    1580                 1585                 1590                        

ttc gtg  aac ttc ctg caa agc  aat atc aag ttc att  ttg gac gcg        4824
Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala            
    1595                 1600                 1605                        

aac ttt  atc atc tcc ggg acc  acg tcc atc ggc cag  ttt gag ttc        4869
Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe            
    1610                 1615                 1620                        

atc tgt  gac gag aac gac aac  att cag ccg tat ttc  atc aag ttc        4914
Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe            
    1625                 1630                 1635                        

aat acc  ttg gaa act aac tac  acc ctg tac gtt ggc  aac cgg caa        4959
Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln            
    1640                 1645                 1650                        

aac atg  att gtc gaa ccc aac  tat gac ttg gat gac  agt ggt gat        5004
Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp            
    1655                 1660                 1665                        

atc agt  agc acc gtg att aac  ttt tcc cag aag tac  ctg tat ggc        5049
Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly            
    1670                 1675                 1680                        

atc gac  tcc tgc gtg aac aaa  gtg gtg atc tcg ccg  aat atc tac        5094
Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr            
    1685                 1690                 1695                        

acg gac  gaa atc aat atc act  ccc gtc tat gaa acc  aac aac acc        5139
Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr            
    1700                 1705                 1710                        

tac ccc  gag gtg att gtc ttg  gat gcg aac tac att  aac gaa aag        5184
Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys            
    1715                 1720                 1725                        

att aac  gtg aac att aac gac  ctg agc atc cgg tat  gtg tgg agt        5229
Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser            
    1730                 1735                 1740                        

aat gac  ggg aac gac ttc att  ctg atg agc acc tcc  gaa gaa aac        5274
Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn            
    1745                 1750                 1755                        

aaa gtc  tcg caa gtc aag atc  cgc ttc gtt aac gtt  ttc aaa gac        5319
Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp            
    1760                 1765                 1770                        

aag acc  ttg gcc aac aaa ctc  agc ttc aat ttc tcg  gac aaa cag        5364
Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln            
    1775                 1780                 1785                        

gac gtg  cct gtg tcg gag atc  att ctc agt ttc acc  ccg agc tac        5409
Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr            
    1790                 1795                 1800                        

tac gag  gac ggc ctg atc ggt  tac gac ctg ggc ctg  gtt agc ctc        5454
Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu            
    1805                 1810                 1815                        

tac aac  gaa aag ttc tat atc  aac aat ttc ggg atg  atg gtt tcg        5499
Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser            
    1820                 1825                 1830                        

ggt ctg  atc tat atc aat gac  agc ttg tac tac ttc  aaa cct ccg        5544
Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro            
    1835                 1840                 1845                        

gtg aac  aat ttg atc acc ggc  ttc gtg acc gtg ggc  gat gac aag        5589
Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys            
    1850                 1855                 1860                        

tac tat  ttc aac ccg att aac  ggt ggc gct gcg tcg  att ggc gaa        5634
Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu            
    1865                 1870                 1875                        

acc atc  atc gac gac aag aac  tac tat ttc aac cag  agc ggt gtg        5679
Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val            
    1880                 1885                 1890                        

ctg caa  acc ggg gtc ttt agc  acg gag gat ggg ttt  aag tat ttc        5724
Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe            
    1895                 1900                 1905                        

gcg cct  gcc aat acc ctg gac  gag aat ttg gag ggc  gaa gcc att        5769
Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile            
    1910                 1915                 1920                        

gac ttc  acc ggc aaa ctg att  atc gac gaa aac atc  tac tat ttc        5814
Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe            
    1925                 1930                 1935                        

gat gac  aac tac cgc ggt gcg  gtc gaa tgg aaa gag  ttg gac ggg        5859
Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly            
    1940                 1945                 1950                        

gag atg  cac tat ttc tcg cca  gag act ggt aag gcc  ttc aag ggc        5904
Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly            
    1955                 1960                 1965                        

ctg aac  cag atc ggc gac tac  aag tac tat ttc aat  agc gac ggc        5949
Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly            
    1970                 1975                 1980                        

gtg atg  cag aag ggg ttc gtc  agc atc aac gac aac  aag cat tac        5994
Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr            
    1985                 1990                 1995                        

ttc gac  gat agc ggc gtt atg  aag gtg ggc tat act  gag atc gac        6039
Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp            
    2000                 2005                 2010                        

ggc aag  cac ttc tat ttc gcc  gag aac ggc gag atg  caa atc ggc        6084
Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly            
    2015                 2020                 2025                        

gtg ttc  aac acc gag gac ggc  ttc aaa tac ttc gct  cat cac aac        6129
Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn            
    2030                 2035                 2040                        

gaa gat  ctc ggt aat gaa gaa  ggt gaa gag att tcc  tat tcg ggc        6174
Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly            
    2045                 2050                 2055                        

atc ctg  aac ttc aac aat aag  atc tac tac ttt gat  gac tcg ttc        6219
Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe            
    2060                 2065                 2070                        

acc gcc  gtg gtg ggt tgg aag  gac ttg gag gac ggg  agc aag tat        6264
Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr            
    2075                 2080                 2085                        

tac ttc  gac gaa gat acc gcc  gag gca tac atc ggc  ttg tcg ctc        6309
Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu            
    2090                 2095                 2100                        

atc aac  gac ggt cag tac tac  ttc aac gac gat ggc  atc atg cag        6354
Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln            
    2105                 2110                 2115                        

gtg ggc  ttc gtg act atc aac  gac aag gtg ttc tac  ttc agt gac        6399
Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp            
    2120                 2125                 2130                        

agt ggc  atc att gag tcg ggc  gtg cag aat atc gac  gat aac tat        6444
Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr            
    2135                 2140                 2145                        

ttc tat  atc gat gac aat ggc  att gtg cag atc ggc  gtg ttt gat        6489
Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp            
    2150                 2155                 2160                        

acc tcc  gat ggg tat aag tat  ttc gca cca gca aat  acc gtc aat        6534
Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn            
    2165                 2170                 2175                        

gac aac  atc tac ggc cag gcc  gtg gag tac agc ggg  ctg gtt cgt        6579
Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg            
    2180                 2185                 2190                        

gtg ggc  gag gac gtt tac tat  ttc ggt gag act tat  act atc gaa        6624
Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu            
    2195                 2200                 2205                        

acc ggc  tgg atc tat gat atg  gaa aac gaa tcg gat  aag tac tac        6669
Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr            
    2210                 2215                 2220                        

ttt aac  cca gaa acg aag aaa  gcc tgc aag ggc atc  aac ctc att        6714
Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile            
    2225                 2230                 2235                        

gat gac  atc aag tat tac ttt  gac gaa aag ggt atc  atg cgc acc        6759
Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr            
    2240                 2245                 2250                        

ggc ctg  atc tcg ttt gag aac  aac aac tac tat ttc  aac gag aat        6804
Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn            
    2255                 2260                 2265                        

ggc gaa  atg cag ttt ggg tac  atc aat atc gag gat  aag atg ttc        6849
Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe            
    2270                 2275                 2280                        

tac ttt  ggg gag gac ggc gtc  atg cag att ggt gtg  ttt aac acc        6894
Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr            
    2285                 2290                 2295                        

ccg gat  ggc ttc aag tac ttc  gcc cat cag aac act  ctg gac gaa        6939
Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu            
    2300                 2305                 2310                        

aac ttc  gag ggc gaa agc atc  aat tac act ggc tgg  ctg gac ctg        6984
Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu            
    2315                 2320                 2325                        

gat gag  aaa cgc tac tac ttc  acc gac gag tac att  gcc gcc acg        7029
Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr            
    2330                 2335                 2340                        

ggc tcc  gtg att atc gac ggc  gaa gaa tac tat ttc  gat ccc gac        7074
Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp            
    2345                 2350                 2355                        

acc gcc  cag ttg gtc att agc  gaa                                     7098
Thr Ala  Gln Leu Val Ile Ser  Glu                                         
    2360                 2365                                             


<210> 34
<211> 613
<212> PRT
<213> Pseudomonas aeruginosa


<220>
<221> MOD_RES
<222> (426)..(426)
<223> His or Tyr

<220>
<221> MOD_RES
<222> (553)..(553)
<223> May or may not be present

<400> 34
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala Xaa Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210> 35
<211> 3119
<212> DNA
<213> Bordetella pertussis


<220>
<221> CDS
<222> (1)..(807)

<220>
<221> CDS
<222> (850)..(1527)

<220>
<221> CDS
<222> (1587)..(1979)

<220>
<221> CDS
<222> (1994)..(2353)

<220>
<221> CDS
<222> (2439)..(3119)

<400> 35
atg cgt tgc act cgg gca att cgc caa acc gca aga aca ggc tgg ctg         48
Met Arg Cys Thr Arg Ala Ile Arg Gln Thr Ala Arg Thr Gly Trp Leu           
1               5                   10                  15                

acg tgg ctg gcg att ctt gcc gtc acg gcg ccc gtg act tcg ccg gca         96
Thr Trp Leu Ala Ile Leu Ala Val Thr Ala Pro Val Thr Ser Pro Ala           
            20                  25                  30                    

tgg gcc gac gat cct ccc gcc acc gta tac cgc tat gac tcc cgc ccg        144
Trp Ala Asp Asp Pro Pro Ala Thr Val Tyr Arg Tyr Asp Ser Arg Pro           
        35                  40                  45                        

ccg gag gac gtt ttc cag aac gga ttc acg gcg tgg gga aac aac gac        192
Pro Glu Asp Val Phe Gln Asn Gly Phe Thr Ala Trp Gly Asn Asn Asp           
    50                  55                  60                            

aat gtg ctc gac cat ctg acc gga cgt tcc tgc cag gtc ggc agc agc        240
Asn Val Leu Asp His Leu Thr Gly Arg Ser Cys Gln Val Gly Ser Ser           
65                  70                  75                  80            

aac agc gct ttc gtc tcc acc agc agc agc cgg cgc tat acc gag gtc        288
Asn Ser Ala Phe Val Ser Thr Ser Ser Ser Arg Arg Tyr Thr Glu Val           
                85                  90                  95                

tat ctc gaa cat cgc atg cag gaa gcg gtc gag gcc gaa cgc gcc ggc        336
Tyr Leu Glu His Arg Met Gln Glu Ala Val Glu Ala Glu Arg Ala Gly           
            100                 105                 110                   

agg ggc acc ggc cac ttc atc ggc tac atc tac gaa gtc cgc gcc gac        384
Arg Gly Thr Gly His Phe Ile Gly Tyr Ile Tyr Glu Val Arg Ala Asp           
        115                 120                 125                       

aac aat ttc tac ggc gcc gcc agc tcg tac ttc gaa tac gtc gac act        432
Asn Asn Phe Tyr Gly Ala Ala Ser Ser Tyr Phe Glu Tyr Val Asp Thr           
    130                 135                 140                           

tat ggc gac aat gcc ggc cgt atc ctc gcc ggc gcg ctg gcc acc tac        480
Tyr Gly Asp Asn Ala Gly Arg Ile Leu Ala Gly Ala Leu Ala Thr Tyr           
145                 150                 155                 160           

cag agc gaa tat ctg gca cac cgg cgc att ccg ccc gaa aac atc cgc        528
Gln Ser Glu Tyr Leu Ala His Arg Arg Ile Pro Pro Glu Asn Ile Arg           
                165                 170                 175               

agg gta acg cgg gtc tat cac aac ggc atc acc ggc gag acc acg acc        576
Arg Val Thr Arg Val Tyr His Asn Gly Ile Thr Gly Glu Thr Thr Thr           
            180                 185                 190                   

acg gag tat tcc aac gct cgc tac gtc agc cag cag act cgc gcc aat        624
Thr Glu Tyr Ser Asn Ala Arg Tyr Val Ser Gln Gln Thr Arg Ala Asn           
        195                 200                 205                       

ccc aac ccc tac aca tcg cga agg tcc gta gcg tcg atc gtc ggc aca        672
Pro Asn Pro Tyr Thr Ser Arg Arg Ser Val Ala Ser Ile Val Gly Thr           
    210                 215                 220                           

ttg gtg cgc atg gcg ccg gtg ata ggc gct tgc atg gcg cgg cag gcc        720
Leu Val Arg Met Ala Pro Val Ile Gly Ala Cys Met Ala Arg Gln Ala           
225                 230                 235                 240           

gaa agc tcc gag gcc atg gca gcc tgg tcc gaa cgc gcc ggc gag gcg        768
Glu Ser Ser Glu Ala Met Ala Ala Trp Ser Glu Arg Ala Gly Glu Ala           
                245                 250                 255               

atg gtt ctc gtg tac tac gaa agc atc gcg tat tcg ttc tagacctggc         817
Met Val Leu Val Tyr Tyr Glu Ser Ile Ala Tyr Ser Phe                       
            260                 265                                       

ccagccccgc ccaactccgg taattgaaca gc atg ccg atc gac cgc aag acg        870
                                    Met Pro Ile Asp Arg Lys Thr           
                                    270                 275               

ctc tgc cat ctc ctg tcc gtt ctg ccg ttg gcc ctc ctc gga tct cac        918
Leu Cys His Leu Leu Ser Val Leu Pro Leu Ala Leu Leu Gly Ser His           
            280                 285                 290                   

gtg gcg cgg gcc tcc acg cca ggc atc gtc att ccg ccg cag gaa cag        966
Val Ala Arg Ala Ser Thr Pro Gly Ile Val Ile Pro Pro Gln Glu Gln           
        295                 300                 305                       

att acc cag cat ggc agc ccc tat gga cgc tgc gcg aac aag acc cgt       1014
Ile Thr Gln His Gly Ser Pro Tyr Gly Arg Cys Ala Asn Lys Thr Arg           
    310                 315                 320                           

gcc ctg acc gtg gcg gaa ttg cgc ggc agc ggc gat ctg cag gag tac       1062
Ala Leu Thr Val Ala Glu Leu Arg Gly Ser Gly Asp Leu Gln Glu Tyr           
325                 330                 335                 340           

ctg cgt cat gtg acg cgc ggc tgg tca ata ttt gcg ctc tac gat ggc       1110
Leu Arg His Val Thr Arg Gly Trp Ser Ile Phe Ala Leu Tyr Asp Gly           
                345                 350                 355               

acc tat ctc ggc ggc gaa tat ggc ggc gtg atc aag gac gga aca ccc       1158
Thr Tyr Leu Gly Gly Glu Tyr Gly Gly Val Ile Lys Asp Gly Thr Pro           
            360                 365                 370                   

ggc ggc gca ttc gac ctg aaa acg acg ttc tgc atc atg acc acg cgc       1206
Gly Gly Ala Phe Asp Leu Lys Thr Thr Phe Cys Ile Met Thr Thr Arg           
        375                 380                 385                       

aat acg ggt caa ccc gca acg gat cac tac tac agc aac gtc acc gcc       1254
Asn Thr Gly Gln Pro Ala Thr Asp His Tyr Tyr Ser Asn Val Thr Ala           
    390                 395                 400                           

act cgc ctg ctc tcc agc acc aac agc agg cta tgc gcg gtc ttc gtc       1302
Thr Arg Leu Leu Ser Ser Thr Asn Ser Arg Leu Cys Ala Val Phe Val           
405                 410                 415                 420           

aga agc ggg caa ccg gtc att ggc gcc tgc acc agc ccg tat gac ggc       1350
Arg Ser Gly Gln Pro Val Ile Gly Ala Cys Thr Ser Pro Tyr Asp Gly           
                425                 430                 435               

aag tac tgg agc atg tac agc cgg ctg cgg aaa atg ctt tac ctg atc       1398
Lys Tyr Trp Ser Met Tyr Ser Arg Leu Arg Lys Met Leu Tyr Leu Ile           
            440                 445                 450                   

tac gtg gcc ggc atc tcc gta cgc gtc cat gtc agc aag gaa gaa cag       1446
Tyr Val Ala Gly Ile Ser Val Arg Val His Val Ser Lys Glu Glu Gln           
        455                 460                 465                       

tat tac gac tat gag gac gca acg ttc gag act tac gcc ctt acc ggc       1494
Tyr Tyr Asp Tyr Glu Asp Ala Thr Phe Glu Thr Tyr Ala Leu Thr Gly           
    470                 475                 480                           

atc tcc atc tgc aat cct gga tca tcc tta tgc tgagacgctt ccccactcga     1547
Ile Ser Ile Cys Asn Pro Gly Ser Ser Leu Cys                               
485                 490                 495                               

accaccgccc cgggacaggg cggcgcccgg cggtcgcgc gtg cgc gcc ctg gcg        1601
                                           Val Arg Ala Leu Ala            
                                                           500            

tgg ttg ctg gca tcc ggc gcg atg acg cat ctt tcc ccc gcc ctg gcc       1649
Trp Leu Leu Ala Ser Gly Ala Met Thr His Leu Ser Pro Ala Leu Ala           
                505                 510                 515               

gac gtt cct tat gtg ctg gtg aag acc aat atg gtg gtc acc agc gta       1697
Asp Val Pro Tyr Val Leu Val Lys Thr Asn Met Val Val Thr Ser Val           
            520                 525                 530                   

gcc atg aag ccg tat gaa gtc acc ccg acg cgc atg ctg gtc tgc ggc       1745
Ala Met Lys Pro Tyr Glu Val Thr Pro Thr Arg Met Leu Val Cys Gly           
        535                 540                 545                       

atc gcc gcc aaa ctg ggc gcc gcg gcc agc agc ccg gac gcg cac gtg       1793
Ile Ala Ala Lys Leu Gly Ala Ala Ala Ser Ser Pro Asp Ala His Val           
    550                 555                 560                           

ccg ttc tgc ttc ggc aag gat ctc aag cgt ccc ggc agc agt ccc atg       1841
Pro Phe Cys Phe Gly Lys Asp Leu Lys Arg Pro Gly Ser Ser Pro Met           
565                 570                 575                 580           

gaa gtc atg ttg cgc gcc gtc ttc atg caa caa cgg ccg ctg cgc atg       1889
Glu Val Met Leu Arg Ala Val Phe Met Gln Gln Arg Pro Leu Arg Met           
                585                 590                 595               

ttt ctg ggt ccc aag caa ctc act ttc gaa ggc aag ccc gcg ctc gaa       1937
Phe Leu Gly Pro Lys Gln Leu Thr Phe Glu Gly Lys Pro Ala Leu Glu           
            600                 605                 610                   

ctg atc cgg atg gtc gaa tgc agc ggc aag cag gat tgc ccc               1979
Leu Ile Arg Met Val Glu Cys Ser Gly Lys Gln Asp Cys Pro                   
        615                 620                 625                       

tgaaggcgaa cccc atg cat acc atc gca tcc atc ctg ttg tcc gtg ctc       2029
                Met His Thr Ile Ala Ser Ile Leu Leu Ser Val Leu           
                            630                 635                       

ggc ata tac agc ccg gct gac gtc gcc ggc ttg ccg acc cat ctg tac       2077
Gly Ile Tyr Ser Pro Ala Asp Val Ala Gly Leu Pro Thr His Leu Tyr           
    640                 645                 650                           

aag aac ttc act gtc cag gag ctg gcc ttg aaa ctg aag ggc aag aat       2125
Lys Asn Phe Thr Val Gln Glu Leu Ala Leu Lys Leu Lys Gly Lys Asn           
655                 660                 665                 670           

cag gag ttc tgc ctg acc gcc ttc atg tcg ggc aga agc ctg gtc cgg       2173
Gln Glu Phe Cys Leu Thr Ala Phe Met Ser Gly Arg Ser Leu Val Arg           
                675                 680                 685               

gcg tgc ctg tcc gac gcg gga cac gag cac gac acg tgg ttc gac acc       2221
Ala Cys Leu Ser Asp Ala Gly His Glu His Asp Thr Trp Phe Asp Thr           
            690                 695                 700                   

atg ctt ggc ttt gcc ata tcc gcg tat gcg ctc aag agc cgg atc gcg       2269
Met Leu Gly Phe Ala Ile Ser Ala Tyr Ala Leu Lys Ser Arg Ile Ala           
        705                 710                 715                       

ctg acg gtg gaa gac tcg ccg tat ccg ggc act ccc ggc gat ctg ctc       2317
Leu Thr Val Glu Asp Ser Pro Tyr Pro Gly Thr Pro Gly Asp Leu Leu           
    720                 725                 730                           

gaa ctg cag atc tgc ccg ctc aac gga tat tgc gaa tgaacccttc            2363
Glu Leu Gln Ile Cys Pro Leu Asn Gly Tyr Cys Glu                           
735                 740                 745                               

cggaggtttc gacgtttccg cgcaatccgc ttgagacgat cttccgccct ggttccattc     2423

cgggaacacc gcaac atg ctg atc aac aac aag aag ctg ctt cat cac att      2474
                 Met Leu Ile Asn Asn Lys Lys Leu Leu His His Ile          
                             750                 755                      

ctg ccc atc ctg gtg ctc gcc ctg ctg ggc atg cgc acg gcc cag gcc       2522
Leu Pro Ile Leu Val Leu Ala Leu Leu Gly Met Arg Thr Ala Gln Ala           
    760                 765                 770                           

gtt gcg cca ggc atc gtc atc ccg ccg aag gca ctg ttc acc caa cag       2570
Val Ala Pro Gly Ile Val Ile Pro Pro Lys Ala Leu Phe Thr Gln Gln           
775                 780                 785                 790           

ggc ggc gcc tat gga cgc tgc ccg aac gga acc cgc gcc ttg acc gtg       2618
Gly Gly Ala Tyr Gly Arg Cys Pro Asn Gly Thr Arg Ala Leu Thr Val           
                795                 800                 805               

gcc gaa ctg cgc ggc aac gcc gaa ttg cag acg tat ttg cgc cag ata       2666
Ala Glu Leu Arg Gly Asn Ala Glu Leu Gln Thr Tyr Leu Arg Gln Ile           
            810                 815                 820                   

acg ccc ggc tgg tcc ata tac ggt ctc tat gac ggt acg tac ctg ggc       2714
Thr Pro Gly Trp Ser Ile Tyr Gly Leu Tyr Asp Gly Thr Tyr Leu Gly           
        825                 830                 835                       

cag gcg tac ggc ggc atc atc aag gac gcg ccg cca ggc gcg ggg ttc       2762
Gln Ala Tyr Gly Gly Ile Ile Lys Asp Ala Pro Pro Gly Ala Gly Phe           
    840                 845                 850                           

att tat cgc gaa act ttc tgc atc acg acc ata tac aag acc ggg caa       2810
Ile Tyr Arg Glu Thr Phe Cys Ile Thr Thr Ile Tyr Lys Thr Gly Gln           
855                 860                 865                 870           

ccg gct gcg gat cac tac tac agc aag gtc acg gcc acg cgc ctg ctc       2858
Pro Ala Ala Asp His Tyr Tyr Ser Lys Val Thr Ala Thr Arg Leu Leu           
                875                 880                 885               

gcc agc acc aac agc agg ctg tgc gcg gta ttc gtc agg gac ggg caa       2906
Ala Ser Thr Asn Ser Arg Leu Cys Ala Val Phe Val Arg Asp Gly Gln           
            890                 895                 900                   

tcg gtc atc gga gcc tgc gcc agc ccg tat gaa ggc agg tac aga gac       2954
Ser Val Ile Gly Ala Cys Ala Ser Pro Tyr Glu Gly Arg Tyr Arg Asp           
        905                 910                 915                       

atg tac gac gcg ctg cgg cgc ctg ctg tac atg atc tat atg tcc ggc       3002
Met Tyr Asp Ala Leu Arg Arg Leu Leu Tyr Met Ile Tyr Met Ser Gly           
    920                 925                 930                           

ctt gcc gta cgc gtc cac gtc agc aag gag gaa cag tat tac gac tac       3050
Leu Ala Val Arg Val His Val Ser Lys Glu Glu Gln Tyr Tyr Asp Tyr           
935                 940                 945                 950           

gag gac gcc aca ttc cag acc tat gcc ctc acc ggc att tcc ctc tgc       3098
Glu Asp Ala Thr Phe Gln Thr Tyr Ala Leu Thr Gly Ile Ser Leu Cys           
                955                 960                 965               

aac ccg gca gcg tcg ata tgc                                           3119
Asn Pro Ala Ala Ser Ile Cys                                               
            970                                                           


<210> 36
<211> 535
<212> PRT
<213> Corynebacterium diphtheriae 

<400> 36
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210> 37
<211> 960
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(960)

<400> 37
ggg gcg gac gat gtg gtg gat tcc tcc aag tcg ttt gtc atg gaa aat         48
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn           
1               5                   10                  15                

ttc tcg tcg tac cat ggc act aag cca ggc tac gtg gat agc att caa         96
Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln           
            20                  25                  30                    

aag ggc atc cag aag ccc aag agc ggt act cag ggg aac tat gac gac        144
Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp           
        35                  40                  45                        

gac tgg aag gga ttt tac agc acc gac aat aag tac gat gct gcg ggc        192
Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly           
    50                  55                  60                            

tat agc gtg gac aac gaa aac cca ttg tcg ggc aag gcc ggt ggc gtg        240
Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val           
65                  70                  75                  80            

gtg aag gtg acc tat cct ggt ctg acg aaa gtt ctg gcg ttg aaa gtg        288
Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val           
                85                  90                  95                

gac aac gcc gag act atc aag aaa gaa ttg ggc ttg agt ttg acc gag        336
Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu           
            100                 105                 110                   

ccg ctg atg gaa cag gtg ggt acc gaa gaa ttc att aaa cgt ttt ggg        384
Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly           
        115                 120                 125                       

gac ggc gcg tcg cgc gtg gtc ctg tcg ttg ccg ttc gcc gaa ggg tcg        432
Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser           
    130                 135                 140                           

tcg tcg gtg gaa tat atc aac aac tgg gaa cag gcc aag gcg ctg tcg        480
Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser           
145                 150                 155                 160           

gtg gaa ctg gaa att aac ttc gaa acg cgg ggc aaa cgg ggc cag gac        528
Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp           
                165                 170                 175               

gcc atg tac gaa tac atg gcg cag gcg tgc gcc ggg aac cgg gtg cgg        576
Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg           
            180                 185                 190                   

cgc agc gtg ggc agt tcc ttg agt tgc atc aat ctg gac tgg gac gtc        624
Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val           
        195                 200                 205                       

atc cgc gat aag acg aag acg aaa atc gag tcg ctc aaa gag cac ggc        672
Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly           
    210                 215                 220                           

ccg atc aaa aac aaa atg agc gag tcg ccg aat aaa acg gtg tcc gag        720
Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu           
225                 230                 235                 240           

gag aag gcg aag caa tac ctg gag gaa ttc cac cag acg gct ctg gag        768
Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu           
                245                 250                 255               

cac ccg gag ctg agc gaa ctc aaa acc gtt acc ggt acg aac ccg gtg        816
His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val           
            260                 265                 270                   

ttt gcc ggg gca aac tat gca gct tgg gcc gtc aac gtg gcc caa gtg        864
Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val           
        275                 280                 285                       

atc gac tcc gaa acg gcc gac aac ctg gaa aag act acc gcc gcg ttg        912
Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu           
    290                 295                 300                           

tcg atc ctc ccg ggc atc ggg agc gtc atg ggt att gcc gat ggt gcg        960
Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala           
305                 310                 315                 320           


<210> 38
<211> 258
<212> PRT
<213> Vibrio cholerae

<400> 38
Met Val Lys Ile Ile Phe Val Phe Phe Ile Phe Leu Ser Ser Phe Ser 
1               5                   10                  15      


Tyr Ala Asn Asp Asp Lys Leu Tyr Arg Ala Asp Ser Arg Pro Pro Asp 
            20                  25                  30          


Glu Ile Lys Gln Ser Gly Gly Leu Met Pro Arg Gly Gln Ser Glu Tyr 
        35                  40                  45              


Phe Asp Arg Gly Thr Gln Met Asn Ile Asn Leu Tyr Asp His Ala Arg 
    50                  55                  60                  


Gly Thr Gln Thr Gly Phe Val Arg His Asp Asp Gly Tyr Val Ser Thr 
65                  70                  75                  80  


Ser Ile Ser Leu Arg Ser Ala His Leu Val Gly Gln Thr Ile Leu Ser 
                85                  90                  95      


Gly His Ser Thr Tyr Tyr Ile Tyr Val Ile Ala Thr Ala Pro Asn Met 
            100                 105                 110         


Phe Asn Val Asn Asp Val Leu Gly Ala Tyr Ser Pro His Pro Asp Glu 
        115                 120                 125             


Gln Glu Val Ser Ala Leu Gly Gly Ile Pro Tyr Ser Gln Ile Tyr Gly 
    130                 135                 140                 


Trp Tyr Arg Val His Phe Gly Val Leu Asp Glu Gln Leu His Arg Asn 
145                 150                 155                 160 


Arg Gly Tyr Arg Asp Arg Tyr Tyr Ser Asn Leu Asp Ile Ala Pro Ala 
                165                 170                 175     


Ala Asp Gly Tyr Gly Leu Ala Gly Phe Pro Pro Glu His Arg Ala Trp 
            180                 185                 190         


Arg Glu Glu Pro Trp Ile His His Ala Pro Pro Gly Cys Gly Asn Ala 
        195                 200                 205             


Pro Arg Ser Ser Met Ser Asn Thr Cys Asp Glu Lys Thr Gln Ser Leu 
    210                 215                 220                 


Gly Val Lys Phe Leu Asp Glu Tyr Gln Ser Lys Val Lys Arg Gln Ile 
225                 230                 235                 240 


Phe Ser Gly Tyr Gln Ser Asp Ile Asp Thr His Asn Arg Ile Lys Asp 
                245                 250                 255     


Glu Leu 
        


<210> 39
<211> 124
<212> PRT
<213> Vibrio cholerae

<400> 39
Met Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser 
1               5                   10                  15      


Ala Tyr Ala His Gly Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu 
            20                  25                  30          


Tyr His Asn Thr Gln Ile Tyr Thr Leu Asn Asp Lys Ile Phe Ser Tyr 
        35                  40                  45              


Thr Glu Ser Leu Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys 
    50                  55                  60                  


Asn Gly Ala Ile Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp 
65                  70                  75                  80  


Ser Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala 
                85                  90                  95      


Tyr Leu Thr Glu Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys 
            100                 105                 110         


Thr Pro His Ala Ile Ala Ala Ile Ser Met Ala Asn 
        115                 120                 


<210> 40
<211> 1148
<212> DNA
<213> Vibrio cholerae

<400> 40
atggtaaaga taatatttgt gttttttatt ttcttatcat cattttcata tgcaaatgat       60

gataagttat atcgggcaga ttctagacct cctgatgaaa taaagcagtc aggtggtctt      120

atgccaagag gacagagtga gtactttgac cgaggtactc aaatgaatat caacctttat      180

gatcatgcaa gaggaactca gacgggattt gttaggcacg atgatggata tgtttccacc      240

tcaattagtt tgagaagtgc ccacttagtg ggtcaaacta tattgtctgg tcattctact      300

tattatatat atgttatagc cactgcaccc aacatgttta acgttaatga tgtattaggg      360

gcatacagtc ctcatccaga tgaacaagaa gtttctgctt taggtgggat tccatactcc      420

caaatatatg gatggtatcg agttcatttt ggggtgcttg atgaacaatt acatcgtaat      480

aggggctaca gagatagata ttacagtaac ttagatattg ctccagcagc agatggttat      540

ggattggcag gtttccctcc ggagcataga gcttggaggg aagagccgtg gattcatcat      600

gcaccgccgg gttgtgggaa tgctccaaga tcatcgatga gtaatacttg cgatgaaaaa      660

acccaaagtc taggtgtaaa attccttgac gaataccaat ctaaagttaa aagacaaata      720

ttttcaggct atcaatctga tattgataca cataatagaa ttaaggatga attatgatta      780

aattaaaatt tggtgttttt tttacagttt tactatcttc agcatatgca catggaacac      840

ctcaaaatat tactgatttg tgtgcagaat accacaacac acaaatatat acgctaaatg      900

ataagatatt ttcgtataca gaatctctag ctggaaaaag agagatggct atcattactt      960

ttaagaatgg tgcaattttt caagtagaag taccaggtag tcaacatata gattcacaaa     1020

aaaaagcgat tgaaaggatg aaggataccc tgaggattgc atatcttact gaagctaaag     1080

tcgaaaagtt atgtgtatgg aataataaaa cgcctcatgc gattgccgca attagtatgg     1140

caaattaa                                                              1148


<210> 41
<211> 269
<212> PRT
<213> Bordetella pertussis

<400> 41
Met Arg Cys Thr Arg Ala Ile Arg Gln Thr Ala Arg Thr Gly Trp Leu 
1               5                   10                  15      


Thr Trp Leu Ala Ile Leu Ala Val Thr Ala Pro Val Thr Ser Pro Ala 
            20                  25                  30          


Trp Ala Asp Asp Pro Pro Ala Thr Val Tyr Arg Tyr Asp Ser Arg Pro 
        35                  40                  45              


Pro Glu Asp Val Phe Gln Asn Gly Phe Thr Ala Trp Gly Asn Asn Asp 
    50                  55                  60                  


Asn Val Leu Asp His Leu Thr Gly Arg Ser Cys Gln Val Gly Ser Ser 
65                  70                  75                  80  


Asn Ser Ala Phe Val Ser Thr Ser Ser Ser Arg Arg Tyr Thr Glu Val 
                85                  90                  95      


Tyr Leu Glu His Arg Met Gln Glu Ala Val Glu Ala Glu Arg Ala Gly 
            100                 105                 110         


Arg Gly Thr Gly His Phe Ile Gly Tyr Ile Tyr Glu Val Arg Ala Asp 
        115                 120                 125             


Asn Asn Phe Tyr Gly Ala Ala Ser Ser Tyr Phe Glu Tyr Val Asp Thr 
    130                 135                 140                 


Tyr Gly Asp Asn Ala Gly Arg Ile Leu Ala Gly Ala Leu Ala Thr Tyr 
145                 150                 155                 160 


Gln Ser Glu Tyr Leu Ala His Arg Arg Ile Pro Pro Glu Asn Ile Arg 
                165                 170                 175     


Arg Val Thr Arg Val Tyr His Asn Gly Ile Thr Gly Glu Thr Thr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Asn Ala Arg Tyr Val Ser Gln Gln Thr Arg Ala Asn 
        195                 200                 205             


Pro Asn Pro Tyr Thr Ser Arg Arg Ser Val Ala Ser Ile Val Gly Thr 
    210                 215                 220                 


Leu Val Arg Met Ala Pro Val Ile Gly Ala Cys Met Ala Arg Gln Ala 
225                 230                 235                 240 


Glu Ser Ser Glu Ala Met Ala Ala Trp Ser Glu Arg Ala Gly Glu Ala 
                245                 250                 255     


Met Val Leu Val Tyr Tyr Glu Ser Ile Ala Tyr Ser Phe 
            260                 265                 


<210> 42
<211> 226
<212> PRT
<213> Bordetella pertussis

<400> 42
Met Pro Ile Asp Arg Lys Thr Leu Cys His Leu Leu Ser Val Leu Pro 
1               5                   10                  15      


Leu Ala Leu Leu Gly Ser His Val Ala Arg Ala Ser Thr Pro Gly Ile 
            20                  25                  30          


Val Ile Pro Pro Gln Glu Gln Ile Thr Gln His Gly Ser Pro Tyr Gly 
        35                  40                  45              


Arg Cys Ala Asn Lys Thr Arg Ala Leu Thr Val Ala Glu Leu Arg Gly 
    50                  55                  60                  


Ser Gly Asp Leu Gln Glu Tyr Leu Arg His Val Thr Arg Gly Trp Ser 
65                  70                  75                  80  


Ile Phe Ala Leu Tyr Asp Gly Thr Tyr Leu Gly Gly Glu Tyr Gly Gly 
                85                  90                  95      


Val Ile Lys Asp Gly Thr Pro Gly Gly Ala Phe Asp Leu Lys Thr Thr 
            100                 105                 110         


Phe Cys Ile Met Thr Thr Arg Asn Thr Gly Gln Pro Ala Thr Asp His 
        115                 120                 125             


Tyr Tyr Ser Asn Val Thr Ala Thr Arg Leu Leu Ser Ser Thr Asn Ser 
    130                 135                 140                 


Arg Leu Cys Ala Val Phe Val Arg Ser Gly Gln Pro Val Ile Gly Ala 
145                 150                 155                 160 


Cys Thr Ser Pro Tyr Asp Gly Lys Tyr Trp Ser Met Tyr Ser Arg Leu 
                165                 170                 175     


Arg Lys Met Leu Tyr Leu Ile Tyr Val Ala Gly Ile Ser Val Arg Val 
            180                 185                 190         


His Val Ser Lys Glu Glu Gln Tyr Tyr Asp Tyr Glu Asp Ala Thr Phe 
        195                 200                 205             


Glu Thr Tyr Ala Leu Thr Gly Ile Ser Ile Cys Asn Pro Gly Ser Ser 
    210                 215                 220                 


Leu Cys 
225     


<210> 43
<211> 131
<212> PRT
<213> Bordetella pertussis

<400> 43
Val Arg Ala Leu Ala Trp Leu Leu Ala Ser Gly Ala Met Thr His Leu 
1               5                   10                  15      


Ser Pro Ala Leu Ala Asp Val Pro Tyr Val Leu Val Lys Thr Asn Met 
            20                  25                  30          


Val Val Thr Ser Val Ala Met Lys Pro Tyr Glu Val Thr Pro Thr Arg 
        35                  40                  45              


Met Leu Val Cys Gly Ile Ala Ala Lys Leu Gly Ala Ala Ala Ser Ser 
    50                  55                  60                  


Pro Asp Ala His Val Pro Phe Cys Phe Gly Lys Asp Leu Lys Arg Pro 
65                  70                  75                  80  


Gly Ser Ser Pro Met Glu Val Met Leu Arg Ala Val Phe Met Gln Gln 
                85                  90                  95      


Arg Pro Leu Arg Met Phe Leu Gly Pro Lys Gln Leu Thr Phe Glu Gly 
            100                 105                 110         


Lys Pro Ala Leu Glu Leu Ile Arg Met Val Glu Cys Ser Gly Lys Gln 
        115                 120                 125             


Asp Cys Pro 
    130     


<210> 44
<211> 120
<212> PRT
<213> Bordetella pertussis

<400> 44
Met His Thr Ile Ala Ser Ile Leu Leu Ser Val Leu Gly Ile Tyr Ser 
1               5                   10                  15      


Pro Ala Asp Val Ala Gly Leu Pro Thr His Leu Tyr Lys Asn Phe Thr 
            20                  25                  30          


Val Gln Glu Leu Ala Leu Lys Leu Lys Gly Lys Asn Gln Glu Phe Cys 
        35                  40                  45              


Leu Thr Ala Phe Met Ser Gly Arg Ser Leu Val Arg Ala Cys Leu Ser 
    50                  55                  60                  


Asp Ala Gly His Glu His Asp Thr Trp Phe Asp Thr Met Leu Gly Phe 
65                  70                  75                  80  


Ala Ile Ser Ala Tyr Ala Leu Lys Ser Arg Ile Ala Leu Thr Val Glu 
                85                  90                  95      


Asp Ser Pro Tyr Pro Gly Thr Pro Gly Asp Leu Leu Glu Leu Gln Ile 
            100                 105                 110         


Cys Pro Leu Asn Gly Tyr Cys Glu 
        115                 120 


<210> 45
<211> 227
<212> PRT
<213> Bordetella pertussis

<400> 45
Met Leu Ile Asn Asn Lys Lys Leu Leu His His Ile Leu Pro Ile Leu 
1               5                   10                  15      


Val Leu Ala Leu Leu Gly Met Arg Thr Ala Gln Ala Val Ala Pro Gly 
            20                  25                  30          


Ile Val Ile Pro Pro Lys Ala Leu Phe Thr Gln Gln Gly Gly Ala Tyr 
        35                  40                  45              


Gly Arg Cys Pro Asn Gly Thr Arg Ala Leu Thr Val Ala Glu Leu Arg 
    50                  55                  60                  


Gly Asn Ala Glu Leu Gln Thr Tyr Leu Arg Gln Ile Thr Pro Gly Trp 
65                  70                  75                  80  


Ser Ile Tyr Gly Leu Tyr Asp Gly Thr Tyr Leu Gly Gln Ala Tyr Gly 
                85                  90                  95      


Gly Ile Ile Lys Asp Ala Pro Pro Gly Ala Gly Phe Ile Tyr Arg Glu 
            100                 105                 110         


Thr Phe Cys Ile Thr Thr Ile Tyr Lys Thr Gly Gln Pro Ala Ala Asp 
        115                 120                 125             


His Tyr Tyr Ser Lys Val Thr Ala Thr Arg Leu Leu Ala Ser Thr Asn 
    130                 135                 140                 


Ser Arg Leu Cys Ala Val Phe Val Arg Asp Gly Gln Ser Val Ile Gly 
145                 150                 155                 160 


Ala Cys Ala Ser Pro Tyr Glu Gly Arg Tyr Arg Asp Met Tyr Asp Ala 
                165                 170                 175     


Leu Arg Arg Leu Leu Tyr Met Ile Tyr Met Ser Gly Leu Ala Val Arg 
            180                 185                 190         


Val His Val Ser Lys Glu Glu Gln Tyr Tyr Asp Tyr Glu Asp Ala Thr 
        195                 200                 205             


Phe Gln Thr Tyr Ala Leu Thr Gly Ile Ser Leu Cys Asn Pro Ala Ala 
    210                 215                 220                 


Ser Ile Cys 
225         


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 46
His His His His His His
1               5     


