                         SEQUENCE LISTING

<110>  Codexis, Inc.
       McDaniel, Robert
       Meshulam-Simon, Galit
       Alvizo, Oscar
       Zhang, Xiyun
 
<120>  Production of Monoterpenes

<130>  90834-799186

<140>  PCT/US11/30606
<141>  2011-03-30

<150>  US 61/319,560
<151>  2010-03-31

<150>  US 61/319,586
<151>  2010-03-31

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a bornyl 
       diphopshate synthase obtained from Salvia officinalis

<400>  1
atgcgtcgtt ctgggaacta ccagccggct ctgtgggaca gtaattacat ccagtctctg       60

aacacacctt acaccgaaga gcgccatctg gaccgcaagg ctgagctgat cgtgcaagtc      120

cgcatcttac tgaaagagaa aatggaaccg gtacagcagc tggaactgat tcacgatttg      180

aaatatttag ggctgtctga ttttttccaa gatgagatta aagaaatttt aggcgtgatc      240

tataacgaac acaaatgttt tcacaacaac gaagtggaaa aaatggattt atactttacc      300

gcattgggtt tccgcttatt gcgtcagcac ggttttaata tttctcagga tgtgtttaat      360

tgctttaaaa acgaaaaagg catcgatttt aaagcatctc tggcccaaga tacaaaaggt      420

atgctgcaac tgtatgaagc gtctttcctg ttacgtaaag gcgaagatac tctggagctg      480

gcgcgtgaat tcgccacgaa atgcctgcag aaaaaactgg atgaaggcgg taacgaaatc      540

gatgagaacc tgctgttatg gattcgtcat agcttagatt taccgctgca ctggcgtatt      600

caaagcgtag aggctcgttg gttcatcgat gcgtatgcgc gccgtccgga tatgaacccg      660

ctgattttcg aattggccaa actgaacttt aacattattc aggcgacaca tcagcaggaa      720

ttaaaagatc tgtctcgctg gtggtctcgc ctgtgcttcc cggaaaaact gccgtttgtt      780

cgtgaccgtt tagtagaatc atttttttgg gcagtgggca tgttcgaacc acaccagcac      840

ggctatcagc gtaaaatggc cgcgaccatc attgtcctgg cgactgtcat tgatgatatt      900

tatgatgtct acggtactct ggacgaactg gaactgttta cggatacttt caagcgctgg      960

gatactgaat ctattacccg tctgccatac tatatgcaac tgtgctactg gggggtccac     1020

aactatatct cggacgcagc gtatgatatt ttaaaggaac atggtttctt ttgcctgcag     1080

tatctgcgta aatcggtcgt cgatttggtt gaagcatact tccacgaagc taagtggtac     1140

cacagcggtt ataccccttc tttggacgaa tacctgaata ttgcgaaaat ttcagttgca     1200

tcgccggcca ttatttcccc gacgtatttt acattcgcga acgctagtca tgacacggcg     1260

gtgatcgatt ccctgtacca atatcatgac atcctgtgct tggctggcat tattctgcgc     1320

ctgccggatg atctgggcac ctcttatttc gaactggcgc gtggtgacgt acctaaaacg     1380

atccagtgtt acatgaaaga aaccaatgca tcagaagaag aggcggtgga acacgttaaa     1440

tttctgattc gtgaagcctg gaaagacatg aataccgcca tcgccgcggg ctatccgttt     1500

ccggatggca tggtagcagg cgccgcgaac atcggtcgtg tggcccagtt catttatctg     1560

cacggtgacg gttttggtgt acagcactct aaaacatatg aacatattgc gggtctgctg     1620

tttgaaccgt atgcgtaa                                                   1638


<210>  2
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a bornyl diphopshate synthase obtained from Salvia 
       officinalis

<400>  2

Met Arg Arg Ser Gly Asn Tyr Gln Pro Ala Leu Trp Asp Ser Asn Tyr 
1               5                   10                  15      


Ile Gln Ser Leu Asn Thr Pro Tyr Thr Glu Glu Arg His Leu Asp Arg 
            20                  25                  30          


Lys Ala Glu Leu Ile Val Gln Val Arg Ile Leu Leu Lys Glu Lys Met 
        35                  40                  45              


Glu Pro Val Gln Gln Leu Glu Leu Ile His Asp Leu Lys Tyr Leu Gly 
    50                  55                  60                  


Leu Ser Asp Phe Phe Gln Asp Glu Ile Lys Glu Ile Leu Gly Val Ile 
65                  70                  75                  80  


Tyr Asn Glu His Lys Cys Phe His Asn Asn Glu Val Glu Lys Met Asp 
                85                  90                  95      


Leu Tyr Phe Thr Ala Leu Gly Phe Arg Leu Leu Arg Gln His Gly Phe 
            100                 105                 110         


Asn Ile Ser Gln Asp Val Phe Asn Cys Phe Lys Asn Glu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Ala Ser Leu Ala Gln Asp Thr Lys Gly Met Leu Gln Leu 
    130                 135                 140                 


Tyr Glu Ala Ser Phe Leu Leu Arg Lys Gly Glu Asp Thr Leu Glu Leu 
145                 150                 155                 160 


Ala Arg Glu Phe Ala Thr Lys Cys Leu Gln Lys Lys Leu Asp Glu Gly 
                165                 170                 175     


Gly Asn Glu Ile Asp Glu Asn Leu Leu Leu Trp Ile Arg His Ser Leu 
            180                 185                 190         


Asp Leu Pro Leu His Trp Arg Ile Gln Ser Val Glu Ala Arg Trp Phe 
        195                 200                 205             


Ile Asp Ala Tyr Ala Arg Arg Pro Asp Met Asn Pro Leu Ile Phe Glu 
    210                 215                 220                 


Leu Ala Lys Leu Asn Phe Asn Ile Ile Gln Ala Thr His Gln Gln Glu 
225                 230                 235                 240 


Leu Lys Asp Leu Ser Arg Trp Trp Ser Arg Leu Cys Phe Pro Glu Lys 
                245                 250                 255     


Leu Pro Phe Val Arg Asp Arg Leu Val Glu Ser Phe Phe Trp Ala Val 
            260                 265                 270         


Gly Met Phe Glu Pro His Gln His Gly Tyr Gln Arg Lys Met Ala Ala 
        275                 280                 285             


Thr Ile Ile Val Leu Ala Thr Val Ile Asp Asp Ile Tyr Asp Val Tyr 
    290                 295                 300                 


Gly Thr Leu Asp Glu Leu Glu Leu Phe Thr Asp Thr Phe Lys Arg Trp 
305                 310                 315                 320 


Asp Thr Glu Ser Ile Thr Arg Leu Pro Tyr Tyr Met Gln Leu Cys Tyr 
                325                 330                 335     


Trp Gly Val His Asn Tyr Ile Ser Asp Ala Ala Tyr Asp Ile Leu Lys 
            340                 345                 350         


Glu His Gly Phe Phe Cys Leu Gln Tyr Leu Arg Lys Ser Val Val Asp 
        355                 360                 365             


Leu Val Glu Ala Tyr Phe His Glu Ala Lys Trp Tyr His Ser Gly Tyr 
    370                 375                 380                 


Thr Pro Ser Leu Asp Glu Tyr Leu Asn Ile Ala Lys Ile Ser Val Ala 
385                 390                 395                 400 


Ser Pro Ala Ile Ile Ser Pro Thr Tyr Phe Thr Phe Ala Asn Ala Ser 
                405                 410                 415     


His Asp Thr Ala Val Ile Asp Ser Leu Tyr Gln Tyr His Asp Ile Leu 
            420                 425                 430         


Cys Leu Ala Gly Ile Ile Leu Arg Leu Pro Asp Asp Leu Gly Thr Ser 
        435                 440                 445             


Tyr Phe Glu Leu Ala Arg Gly Asp Val Pro Lys Thr Ile Gln Cys Tyr 
    450                 455                 460                 


Met Lys Glu Thr Asn Ala Ser Glu Glu Glu Ala Val Glu His Val Lys 
465                 470                 475                 480 


Phe Leu Ile Arg Glu Ala Trp Lys Asp Met Asn Thr Ala Ile Ala Ala 
                485                 490                 495     


Gly Tyr Pro Phe Pro Asp Gly Met Val Ala Gly Ala Ala Asn Ile Gly 
            500                 505                 510         


Arg Val Ala Gln Phe Ile Tyr Leu His Gly Asp Gly Phe Gly Val Gln 
        515                 520                 525             


His Ser Lys Thr Tyr Glu His Ile Ala Gly Leu Leu Phe Glu Pro Tyr 
    530                 535                 540                 


Ala 
545 


<210>  3
<211>  1644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a bornyl 
       diphopshate synthase obtained from Rosemarinus officinalis

<400>  3
atgcgtcgta gcggtaacta tcagccgtca agttgggatt tcaattacat ccaaagcctt       60

aataccccat acaaagaaga acgtcaactg aaccgtgaag ccgaacttat tgtccaagtg      120

aagatgttgc tgaaagagaa acgtgaatat gtaaagcagt tggaactgat tgacgatctt      180

aaatatttag ggctgtctta cttcttccaa gatgagatta aagaaattct gggctttatc      240

tataacgaac acaaatggtt agacaacagc gaagcggatg aacgtgattt atacttaaag      300

gcattgggtt tccgtatctt gcgtcagcac ggtttcaatg tttctcagga agtgtttgat      360

tgctttaaga atgagaaggg cagcgacttc aaagcatctc tggcccaaga taccaaaggt      420

attctgcaac tgtatgaagc ggctttcctg ttacgtgaag gcgaagatac tctggagctg      480

gcgcgtgcat tcgccacgaa atgcttacag aagaaactgg atgaaggcgg tgacggaatt      540

gatgagaacc tgctgtcatg gattcgtcat agcttagatt taccgctgca ctggcgtatt      600

caacgtttag aggctcgttg gttcttagat gcgtatgcgc gtcgtccgga tatgaacccg      660

ctgatctttg aattggccaa actggacttt aacattattc aggcgacata tcagcaggaa      720

ttaaaggatg tgtctcgttg gtggaatcgt ctgggcttag cggagaaact gccgtttgtt      780

cgtgaccgta ttgtagaatc atatttctgg ggagtgggca tgttcgaacc aaaccagtac      840

ggctatcagc gtaagatgtc cgggatcatc attatgctgg cgactgtcat tgatgatgtt      900

tatgatgttt atggtactct ggacgaactg caactgttta cggatactat ccgtagcttt      960

agttgggata ctgaatctat ttcccaactg ccatactata tgcaactgtg ctacttggcg     1020

ttatacaact ttgtcagtga attagcgtat gataatttaa aggaacaaca tttcatttcc     1080

attccgtatc tgcataaatc ctgggtcgat ttggctgaag catacttgaa ggaagctaag     1140

tggtactaca gcggttatac cccttctttg gaagaatacc tgagtaatgc gaagatctca     1200

attgcaagtc cgaacattat ttcccagttg cactttacat tagcgaactc tagtactgac     1260

aagtggagta tcgaatccct gtaccaatat cataacatcc tgaacttgtc tggcatgctt     1320

ctgcgtctgg cggatgatgt gggcaccgct cctttcgaac tgaagcgtgg tgacgtacag     1380

aaggcgatcc agtgtcacat gaaagatcgt aatgccagtg agaaggaggc gcaggaacac     1440

gttatgtttc tgcttcgtga agcctggaaa gaaatgaata ccgcaatggc tgatggctat     1500

ccgtttgcgg atgaattggt agcagccgcc gcgaacttag gtcgtgtggc ccagttcatg     1560

tatctggaag gtgacggtca tggtgtacag cactctggta ttcatcaaca aatggcgggt     1620

ctgctgtttg aaccatatac ctaa                                            1644


<210>  4
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a bornyl diphopshate synthase obtained from 
       Rosemarinus officinalis

<400>  4

Met Arg Arg Ser Gly Asn Tyr Gln Pro Ser Ser Trp Asp Phe Asn Tyr 
1               5                   10                  15      


Ile Gln Ser Leu Asn Thr Pro Tyr Lys Glu Glu Arg Gln Leu Asn Arg 
            20                  25                  30          


Glu Ala Glu Leu Ile Val Gln Val Lys Met Leu Leu Lys Glu Lys Arg 
        35                  40                  45              


Glu Tyr Val Lys Gln Leu Glu Leu Ile Asp Asp Leu Lys Tyr Leu Gly 
    50                  55                  60                  


Leu Ser Tyr Phe Phe Gln Asp Glu Ile Lys Glu Ile Leu Gly Phe Ile 
65                  70                  75                  80  


Tyr Asn Glu His Lys Trp Leu Asp Asn Ser Glu Ala Asp Glu Arg Asp 
                85                  90                  95      


Leu Tyr Leu Lys Ala Leu Gly Phe Arg Ile Leu Arg Gln His Gly Phe 
            100                 105                 110         


Asn Val Ser Gln Glu Val Phe Asp Cys Phe Lys Asn Glu Lys Gly Ser 
        115                 120                 125             


Asp Phe Lys Ala Ser Leu Ala Gln Asp Thr Lys Gly Ile Leu Gln Leu 
    130                 135                 140                 


Tyr Glu Ala Ala Phe Leu Leu Arg Glu Gly Glu Asp Thr Leu Glu Leu 
145                 150                 155                 160 


Ala Arg Ala Phe Ala Thr Lys Cys Leu Gln Lys Lys Leu Asp Glu Gly 
                165                 170                 175     


Gly Asp Gly Ile Asp Glu Asn Leu Leu Ser Trp Ile Arg His Ser Leu 
            180                 185                 190         


Asp Leu Pro Leu His Trp Arg Ile Gln Arg Leu Glu Ala Arg Trp Phe 
        195                 200                 205             


Leu Asp Ala Tyr Ala Arg Arg Pro Asp Met Asn Pro Leu Ile Phe Glu 
    210                 215                 220                 


Leu Ala Lys Leu Asp Phe Asn Ile Ile Gln Ala Thr Tyr Gln Gln Glu 
225                 230                 235                 240 


Leu Lys Asp Val Ser Arg Trp Trp Asn Arg Leu Gly Leu Ala Glu Lys 
                245                 250                 255     


Leu Pro Phe Val Arg Asp Arg Ile Val Glu Ser Tyr Phe Trp Gly Val 
            260                 265                 270         


Gly Met Phe Glu Pro Asn Gln Tyr Gly Tyr Gln Arg Lys Met Ser Gly 
        275                 280                 285             


Ile Ile Ile Met Leu Ala Thr Val Ile Asp Asp Val Tyr Asp Val Tyr 
    290                 295                 300                 


Gly Thr Leu Asp Glu Leu Gln Leu Phe Thr Asp Thr Ile Arg Ser Phe 
305                 310                 315                 320 


Ser Trp Asp Thr Glu Ser Ile Ser Gln Leu Pro Tyr Tyr Met Gln Leu 
                325                 330                 335     


Cys Tyr Leu Ala Leu Tyr Asn Phe Val Ser Glu Leu Ala Tyr Asp Asn 
            340                 345                 350         


Leu Lys Glu Gln His Phe Ile Ser Ile Pro Tyr Leu His Lys Ser Trp 
        355                 360                 365             


Val Asp Leu Ala Glu Ala Tyr Leu Lys Glu Ala Lys Trp Tyr Tyr Ser 
    370                 375                 380                 


Gly Tyr Thr Pro Ser Leu Glu Glu Tyr Leu Ser Asn Ala Lys Ile Ser 
385                 390                 395                 400 


Ile Ala Ser Pro Asn Ile Ile Ser Gln Leu His Phe Thr Leu Ala Asn 
                405                 410                 415     


Ser Ser Thr Asp Lys Trp Ser Ile Glu Ser Leu Tyr Gln Tyr His Asn 
            420                 425                 430         


Ile Leu Asn Leu Ser Gly Met Leu Leu Arg Leu Ala Asp Asp Val Gly 
        435                 440                 445             


Thr Ala Pro Phe Glu Leu Lys Arg Gly Asp Val Gln Lys Ala Ile Gln 
    450                 455                 460                 


Cys His Met Lys Asp Arg Asn Ala Ser Glu Lys Glu Ala Gln Glu His 
465                 470                 475                 480 


Val Met Phe Leu Leu Arg Glu Ala Trp Lys Glu Met Asn Thr Ala Met 
                485                 490                 495     


Ala Asp Gly Tyr Pro Phe Ala Asp Glu Leu Val Ala Ala Ala Ala Asn 
            500                 505                 510         


Leu Gly Arg Val Ala Gln Phe Met Tyr Leu Glu Gly Asp Gly His Gly 
        515                 520                 525             


Val Gln His Ser Gly Ile His Gln Gln Met Ala Gly Leu Leu Phe Glu 
    530                 535                 540                 


Pro Tyr Thr 
545         


<210>  5
<211>  1713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a camphene 
       synthase obtained from Pseudotsuga menzeseii

<400>  5
atgcgtcgtg tcggtaacta tcattctaac ttatgggacg atgatttcat taatagtctg       60

atctcaactc cttatgaagc gccatcatat cgtgaacgtg gcgagacgtt gattggtgag      120

gtgaaagaaa tcttcaacag cattagcgtg gaggacgccg gggagttgat taccccgtta      180

aatgacctga tccaacgtct gtggatggtt gacagcgtgg aacgtttagg catcgaccgt      240

cacttcaaag atgaaatcaa gagtgcactg gattatgtat atagtcattg gcgtgaagaa      300

ggcatcggct gtggtcgtga gagtgtagca actgatttaa attctacagc gttaggtctg      360

cgtaccctgc gtctgcatgg ttatccggtt agtagcgacg tgttagaaca tttcaaagac      420

cagaaagggc acttcgcttc ctgttcaagc agtagtattg agaccggtgg ggagattcgt      480

agcgtgctga acctgtttcg tgcgagtctg attgcgttcc caaacgagaa agtcatggac      540

gaagcccaaa tcttctctac cacgtattta aaggaagccg tgcagaagat cccagtgagt      600

tctctgtctc gtcaaatcga atacgtcatg gaatacggtt gggataccaa cctgccacgt      660

ctggaggccc gtcactacat ccatgtgttg ggccaagaca ttacctataa tgataatgaa      720

atgccctata caaatgtaga gaaactgctg gaattggcga agctggaatt taacatgttc      780

cattctttgc aacaacgtga actgaaacac ctgtcccgtt ggtggaagga tagtggtatg      840

ccagaagcga cctttacccg tcatcgtcat gttgagtact atgccctggc aagttgtatc      900

gcgtttgaac cgcagcacag tgggttccga ttcggctttg cgaaattatg ccacattatt      960

accgtgctgg atgacatgta tgatttattc ggcaccattg atgagctgga actgtttacc     1020

gccgccatta aacgttggga ccctagtgcc accgactgct taccggaata tatgaaaggt     1080

gtgtacacta tggtttatga tactatcaat gagatggcag gcgaggccca gaatgcacag     1140

ggccgtgaca cattgaacta cgcacgtgaa gcgtgggaag cctgtttaga ttcctatttg     1200

caggaggcca aatggattgc aaccgggtat ctgcctagct ttgaagagta ctatgagaat     1260

ggtaaagtca gtagtgctca ccgtgtctgc accttacagc cgattctgac gttggatatt     1320

ccatttcctg atcatattct gaaagaggtg gatttcccgt ctaaactgaa cgacctggcc     1380

tgcgccgttc tgcgtctgcg tggtgatacc cgttgttatc aggccgaccg tgcgcgtggt     1440

gaagaagcca gttctatttc atgttacatg aaggataatc caggttccac tgaagaagat     1500

gcgctgaacc acatcaatgc catgcttagt gacgttatca aggaactgaa ctgggaactg     1560

ttgaagcctg acagcgtgcc gattagcgct aagaaacatg cgtatgatgt cagtcgtgca     1620

ttccattacg gctacaaata ccgtgacggt tatagcgtgg ctaatattga aattaagaac     1680

ttcgtggcta ttagtgtgct ggaacccgta taa                                  1713


<210>  6
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a camphene synthase obtained from Pseudotsuga 
       menzeseii

<400>  6

Met Arg Arg Val Gly Asn Tyr His Ser Asn Leu Trp Asp Asp Asp Phe 
1               5                   10                  15      


Ile Asn Ser Leu Ile Ser Thr Pro Tyr Glu Ala Pro Ser Tyr Arg Glu 
            20                  25                  30          


Arg Gly Glu Thr Leu Ile Gly Glu Val Lys Glu Ile Phe Asn Ser Ile 
        35                  40                  45              


Ser Val Glu Asp Ala Gly Glu Leu Ile Thr Pro Leu Asn Asp Leu Ile 
    50                  55                  60                  


Gln Arg Leu Trp Met Val Asp Ser Val Glu Arg Leu Gly Ile Asp Arg 
65                  70                  75                  80  


His Phe Lys Asp Glu Ile Lys Ser Ala Leu Asp Tyr Val Tyr Ser His 
                85                  90                  95      


Trp Arg Glu Glu Gly Ile Gly Cys Gly Arg Glu Ser Val Ala Thr Asp 
            100                 105                 110         


Leu Asn Ser Thr Ala Leu Gly Leu Arg Thr Leu Arg Leu His Gly Tyr 
        115                 120                 125             


Pro Val Ser Ser Asp Val Leu Glu His Phe Lys Asp Gln Lys Gly His 
    130                 135                 140                 


Phe Ala Ser Cys Ser Ser Ser Ser Ile Glu Thr Gly Gly Glu Ile Arg 
145                 150                 155                 160 


Ser Val Leu Asn Leu Phe Arg Ala Ser Leu Ile Ala Phe Pro Asn Glu 
                165                 170                 175     


Lys Val Met Asp Glu Ala Gln Ile Phe Ser Thr Thr Tyr Leu Lys Glu 
            180                 185                 190         


Ala Val Gln Lys Ile Pro Val Ser Ser Leu Ser Arg Gln Ile Glu Tyr 
        195                 200                 205             


Val Met Glu Tyr Gly Trp Asp Thr Asn Leu Pro Arg Leu Glu Ala Arg 
    210                 215                 220                 


His Tyr Ile His Val Leu Gly Gln Asp Ile Thr Tyr Asn Asp Asn Glu 
225                 230                 235                 240 


Met Pro Tyr Thr Asn Val Glu Lys Leu Leu Glu Leu Ala Lys Leu Glu 
                245                 250                 255     


Phe Asn Met Phe His Ser Leu Gln Gln Arg Glu Leu Lys His Leu Ser 
            260                 265                 270         


Arg Trp Trp Lys Asp Ser Gly Met Pro Glu Ala Thr Phe Thr Arg His 
        275                 280                 285             


Arg His Val Glu Tyr Tyr Ala Leu Ala Ser Cys Ile Ala Phe Glu Pro 
    290                 295                 300                 


Gln His Ser Gly Phe Arg Phe Gly Phe Ala Lys Leu Cys His Ile Ile 
305                 310                 315                 320 


Thr Val Leu Asp Asp Met Tyr Asp Leu Phe Gly Thr Ile Asp Glu Leu 
                325                 330                 335     


Glu Leu Phe Thr Ala Ala Ile Lys Arg Trp Asp Pro Ser Ala Thr Asp 
            340                 345                 350         


Cys Leu Pro Glu Tyr Met Lys Gly Val Tyr Thr Met Val Tyr Asp Thr 
        355                 360                 365             


Ile Asn Glu Met Ala Gly Glu Ala Gln Asn Ala Gln Gly Arg Asp Thr 
    370                 375                 380                 


Leu Asn Tyr Ala Arg Glu Ala Trp Glu Ala Cys Leu Asp Ser Tyr Leu 
385                 390                 395                 400 


Gln Glu Ala Lys Trp Ile Ala Thr Gly Tyr Leu Pro Ser Phe Glu Glu 
                405                 410                 415     


Tyr Tyr Glu Asn Gly Lys Val Ser Ser Ala His Arg Val Cys Thr Leu 
            420                 425                 430         


Gln Pro Ile Leu Thr Leu Asp Ile Pro Phe Pro Asp His Ile Leu Lys 
        435                 440                 445             


Glu Val Asp Phe Pro Ser Lys Leu Asn Asp Leu Ala Cys Ala Val Leu 
    450                 455                 460                 


Arg Leu Arg Gly Asp Thr Arg Cys Tyr Gln Ala Asp Arg Ala Arg Gly 
465                 470                 475                 480 


Glu Glu Ala Ser Ser Ile Ser Cys Tyr Met Lys Asp Asn Pro Gly Ser 
                485                 490                 495     


Thr Glu Glu Asp Ala Leu Asn His Ile Asn Ala Met Leu Ser Asp Val 
            500                 505                 510         


Ile Lys Glu Leu Asn Trp Glu Leu Leu Lys Pro Asp Ser Val Pro Ile 
        515                 520                 525             


Ser Ala Lys Lys His Ala Tyr Asp Val Ser Arg Ala Phe His Tyr Gly 
    530                 535                 540                 


Tyr Lys Tyr Arg Asp Gly Tyr Ser Val Ala Asn Ile Glu Ile Lys Asn 
545                 550                 555                 560 


Phe Val Ala Ile Ser Val Leu Glu Pro Val 
                565                 570 


<210>  7
<211>  1683
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a camphene 
       synthase obtained from Abies Grandis

<400>  7
atgcgtcgtg tgggtaatta ccactcaaac ttgtgggatg atgactttat tcaaagtctg       60

attagcacgc cttacggagc ccccgactat cgtgaacgtg ccgatcgttt aattggtgag      120

gtgaaagaca ttatgttcaa cttcaagagc ttggaggacg gggggaatga cctgttacaa      180

cgtctgttgt tagttgacga cgtggaacgt ttaggcatcg accgtcactt caagaaagaa      240

atcaagaccg cactggatta tgtaaatagt tattggaacg agaagggcat cggctgtggt      300

cgtgagagtg tagtaactga tttaaattct acagcgttag gtctgcgtac cctgcgtctg      360

catggttata cggttagtag cgacgtgtta aatgtgttta aagacaagaa tgggcagttt      420

agttccactg caaacattca gatcgaaggg gagattcgtg gcgtgctgaa cctgtttcgt      480

gcgagtctgg ttgcgttccc aggcgagaaa gtcatggacg aagccgaaac tttctctacc      540

aagtatttac gtgaagcctt acagaagatc ccagcgagtt ctattctgtc tcttgaaatc      600

cgtgatgttc tggaatacgg ttggcatacc aacctgccac gtctggaggc ccgtaactac      660

atggatgtct ttggccaaca cacgaagaac aagaacgcag cagagaagct gctggaattg      720

gcgaagctgg aatttaacat ctttcattct ttgcaagaac gtgaactgaa acacgtgtcc      780

cgttggtgga aggatagtgg ttctccagaa atgactttct gtcgtcatcg tcatgttgag      840

tactatgccc tggcaagttg tatcgcgttt gaaccgcagc acagtgggtt ccgtttgggc      900

tttacgaaga tgtcccacct gattaccgtg ctggatgaca tgtatgatgt cttcggcacc      960

gtcgatgagc tggaactgtt tactgcaacc attaaacgtt gggaccctag tgcaatggaa     1020

tgcttaccgg aatatatgaa aggtgtgtac atgatggttt atcatactgt caatgagatg     1080

gcacgtgtgg ccgagaaagc acagggccgt gacacattga actacgcacg tcaagcgtgg     1140

gaagcctgtt tcgattccta tatgcaggag gccaaatgga ttgcaaccgg gtatctgcct     1200

acctttgaag agtacttaga gaatggtaaa gtcagtagtg ctcaccgtcc ctgcgcctta     1260

cagccgattc tgacgttgga tattccattt cctgatcata ttctgaaaga ggtggatttc     1320

ccgtctaaac tgaacgacct gatctgcatc attctgcgtc tgcgtggtga tacccgttgt     1380

tataaggccg accgtgcgcg tggtgaagaa gccagttcta tttcatgtta catgaaggat     1440

aatccaggtt taactgaaga agatgcgctg aaccacatca atttcatgat tcgtgacgct     1500

atccgtgaac tgaactggga actgttgaag cctgacaata gcgtgccgat tacctccaag     1560

aagcatgcgt ttgatattag tcgtgtatgg catcacggct accgttaccg tgacggttat     1620

agctttgcta atgtggaaac aaagtctctg gtgatgcgta ctgtgattga acccgtacca     1680

ctg                                                                   1683


<210>  8
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a camphene synthase obtained from Abies grandis

<400>  8

Met Arg Arg Val Gly Asn Tyr His Ser Asn Leu Trp Asp Asp Asp Phe 
1               5                   10                  15      


Ile Gln Ser Leu Ile Ser Thr Pro Tyr Gly Ala Pro Asp Tyr Arg Glu 
            20                  25                  30          


Arg Ala Asp Arg Leu Ile Gly Glu Val Lys Asp Ile Met Phe Asn Phe 
        35                  40                  45              


Lys Ser Leu Glu Asp Gly Gly Asn Asp Leu Leu Gln Arg Leu Leu Leu 
    50                  55                  60                  


Val Asp Asp Val Glu Arg Leu Gly Ile Asp Arg His Phe Lys Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Ala Leu Asp Tyr Val Asn Ser Tyr Trp Asn Glu Lys Gly 
                85                  90                  95      


Ile Gly Cys Gly Arg Glu Ser Val Val Thr Asp Leu Asn Ser Thr Ala 
            100                 105                 110         


Leu Gly Leu Arg Thr Leu Arg Leu His Gly Tyr Thr Val Ser Ser Asp 
        115                 120                 125             


Val Leu Asn Val Phe Lys Asp Lys Asn Gly Gln Phe Ser Ser Thr Ala 
    130                 135                 140                 


Asn Ile Gln Ile Glu Gly Glu Ile Arg Gly Val Leu Asn Leu Phe Arg 
145                 150                 155                 160 


Ala Ser Leu Val Ala Phe Pro Gly Glu Lys Val Met Asp Glu Ala Glu 
                165                 170                 175     


Thr Phe Ser Thr Lys Tyr Leu Arg Glu Ala Leu Gln Lys Ile Pro Ala 
            180                 185                 190         


Ser Ser Ile Leu Ser Leu Glu Ile Arg Asp Val Leu Glu Tyr Gly Trp 
        195                 200                 205             


His Thr Asn Leu Pro Arg Leu Glu Ala Arg Asn Tyr Met Asp Val Phe 
    210                 215                 220                 


Gly Gln His Thr Lys Asn Lys Asn Ala Ala Glu Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Ala Lys Leu Glu Phe Asn Ile Phe His Ser Leu Gln Glu Arg Glu Leu 
                245                 250                 255     


Lys His Val Ser Arg Trp Trp Lys Asp Ser Gly Ser Pro Glu Met Thr 
            260                 265                 270         


Phe Cys Arg His Arg His Val Glu Tyr Tyr Ala Leu Ala Ser Cys Ile 
        275                 280                 285             


Ala Phe Glu Pro Gln His Ser Gly Phe Arg Leu Gly Phe Thr Lys Met 
    290                 295                 300                 


Ser His Leu Ile Thr Val Leu Asp Asp Met Tyr Asp Val Phe Gly Thr 
305                 310                 315                 320 


Val Asp Glu Leu Glu Leu Phe Thr Ala Thr Ile Lys Arg Trp Asp Pro 
                325                 330                 335     


Ser Ala Met Glu Cys Leu Pro Glu Tyr Met Lys Gly Val Tyr Met Met 
            340                 345                 350         


Val Tyr His Thr Val Asn Glu Met Ala Arg Val Ala Glu Lys Ala Gln 
        355                 360                 365             


Gly Arg Asp Thr Leu Asn Tyr Ala Arg Gln Ala Trp Glu Ala Cys Phe 
    370                 375                 380                 


Asp Ser Tyr Met Gln Glu Ala Lys Trp Ile Ala Thr Gly Tyr Leu Pro 
385                 390                 395                 400 


Thr Phe Glu Glu Tyr Leu Glu Asn Gly Lys Val Ser Ser Ala His Arg 
                405                 410                 415     


Pro Cys Ala Leu Gln Pro Ile Leu Thr Leu Asp Ile Pro Phe Pro Asp 
            420                 425                 430         


His Ile Leu Lys Glu Val Asp Phe Pro Ser Lys Leu Asn Asp Leu Ile 
        435                 440                 445             


Cys Ile Ile Leu Arg Leu Arg Gly Asp Thr Arg Cys Tyr Lys Ala Asp 
    450                 455                 460                 


Arg Ala Arg Gly Glu Glu Ala Ser Ser Ile Ser Cys Tyr Met Lys Asp 
465                 470                 475                 480 


Asn Pro Gly Leu Thr Glu Glu Asp Ala Leu Asn His Ile Asn Phe Met 
                485                 490                 495     


Ile Arg Asp Ala Ile Arg Glu Leu Asn Trp Glu Leu Leu Lys Pro Asp 
            500                 505                 510         


Asn Ser Val Pro Ile Thr Ser Lys Lys His Ala Phe Asp Ile Ser Arg 
        515                 520                 525             


Val Trp His His Gly Tyr Arg Tyr Arg Asp Gly Tyr Ser Phe Ala Asn 
    530                 535                 540                 


Val Glu Thr Lys Ser Leu Val Met Arg Thr Val Ile Glu Pro Val Pro 
545                 550                 555                 560 


Leu 
    


<210>  9
<211>  1641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a TPS10 synthase
       obtained from Arabidopsis thaliana

<400>  9
atgcgccgct cggcgaacta ccagccgtcc cgctgggatc accaccacct gctgtcggtg       60

gaaaataagt tcgccaaaga caaacgcgtt cgcgagcgcg atctgttaaa agaaaaagta      120

cgtaaaatgt tgaacgacga acagaaaacc tatctggacc agctggaatt tattgacgac      180

ttgcagaagt tgggcgtgtc gtaccacttt gaggcagaga ttgacaatat tctgacgtcc      240

tcatacaaaa aggaccgcac caacattcag gaaagtgatc tgcatgccac agctctggaa      300

tttcgtctgt tccgccagca tggtttcaac gttagcgaag acgtgtttga tgtatttatg      360

gaaaactgcg gcaaattcga tcgtgatgac atctacggtc tgatcagttt atatgaggct      420

tcctatctgt ctacgaaatt ggataagaat ctgcaaatct ttattcgtcc gtttgctacg      480

cagcagctgc gcgatttcgt ggatacacac tccaacgaag acttcggttc gtgtgacatg      540

gttgaaattg ttgtacaggc tctggatatg ccatactact ggcagatgcg tcgtttatcg      600

acccgctggt atattgacgt ctacggtaaa cgtcaaaatt acaagaatct ggtagttgtt      660

gaatttgcaa aaattgactt taacatcgtc caggccattc accaggagga actgaaaaac      720

gtgtcatcgt ggtggatgga aacaggtctg gggaagcagc tgtactttgc ccgcgaccgt      780

atcgtagaaa actacttttg gaccattggc caaattcaag aaccgcagta tggttacgtt      840

cgtcaaacaa tgacgaaaat caatgcgttg ttaacgacta tcgatgacat ctatgatatc      900

tacggcacgt tggaagaact gcaactgttc actgtcgcat tcgaaaactg ggacatcaac      960

cgcctggatg aactgccgga atacatgcgt ctgtgctttc tggtcatcta caacgaagtg     1020

aactcaatcg cgtgcgaaat tctgcgtacg aaaaacatca acgttattcc ttttttgaaa     1080

aaaagctgga ccgacgtttc taaggcatat ctggttgaag ctaaatggta taaatctggc     1140

cacaaaccga atctggaaga atacatgcag aatgcgcgca ttagtatttc cagtccgact     1200

atcttcgtgc acttttactg cgtattctct gaccaactga gtatccaagt tctggaaacc     1260

ttaagccagc accaacagaa tgtggttcgt tgcagttctt cagttttccg tctggcgaac     1320

gacttagtaa cttccccgga tgaattggcc cgtggcgatg tgtgcaaatc gatccaatgt     1380

tacatgtccg aaacgggtgc ctctgaagat aaagcacgca gtcacgtccg ccagatgatt     1440

aatgatctgt gggatgagat gaattatgaa aaaatggccc attcatcttc tattctgcac     1500

cacgatttta tggaaacggt gatcaactta gcccgcatgt cgcagtgcat gtatcagtat     1560

ggcgatggcc acgggtctcc ggaaaaagcg aaaattgtcg accgtgtcat gtcactgctg     1620

tttaatccta ttccgctgga t                                               1641


<210>  10
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a TPS10 synthase obtained from Arabidopsis thaliana

<400>  10

Met Arg Arg Ser Ala Asn Tyr Gln Pro Ser Arg Trp Asp His His His 
1               5                   10                  15      


Leu Leu Ser Val Glu Asn Lys Phe Ala Lys Asp Lys Arg Val Arg Glu 
            20                  25                  30          


Arg Asp Leu Leu Lys Glu Lys Val Arg Lys Met Leu Asn Asp Glu Gln 
        35                  40                  45              


Lys Thr Tyr Leu Asp Gln Leu Glu Phe Ile Asp Asp Leu Gln Lys Leu 
    50                  55                  60                  


Gly Val Ser Tyr His Phe Glu Ala Glu Ile Asp Asn Ile Leu Thr Ser 
65                  70                  75                  80  


Ser Tyr Lys Lys Asp Arg Thr Asn Ile Gln Glu Ser Asp Leu His Ala 
                85                  90                  95      


Thr Ala Leu Glu Phe Arg Leu Phe Arg Gln His Gly Phe Asn Val Ser 
            100                 105                 110         


Glu Asp Val Phe Asp Val Phe Met Glu Asn Cys Gly Lys Phe Asp Arg 
        115                 120                 125             


Asp Asp Ile Tyr Gly Leu Ile Ser Leu Tyr Glu Ala Ser Tyr Leu Ser 
    130                 135                 140                 


Thr Lys Leu Asp Lys Asn Leu Gln Ile Phe Ile Arg Pro Phe Ala Thr 
145                 150                 155                 160 


Gln Gln Leu Arg Asp Phe Val Asp Thr His Ser Asn Glu Asp Phe Gly 
                165                 170                 175     


Ser Cys Asp Met Val Glu Ile Val Val Gln Ala Leu Asp Met Pro Tyr 
            180                 185                 190         


Tyr Trp Gln Met Arg Arg Leu Ser Thr Arg Trp Tyr Ile Asp Val Tyr 
        195                 200                 205             


Gly Lys Arg Gln Asn Tyr Lys Asn Leu Val Val Val Glu Phe Ala Lys 
    210                 215                 220                 


Ile Asp Phe Asn Ile Val Gln Ala Ile His Gln Glu Glu Leu Lys Asn 
225                 230                 235                 240 


Val Ser Ser Trp Trp Met Glu Thr Gly Leu Gly Lys Gln Leu Tyr Phe 
                245                 250                 255     


Ala Arg Asp Arg Ile Val Glu Asn Tyr Phe Trp Thr Ile Gly Gln Ile 
            260                 265                 270         


Gln Glu Pro Gln Tyr Gly Tyr Val Arg Gln Thr Met Thr Lys Ile Asn 
        275                 280                 285             


Ala Leu Leu Thr Thr Ile Asp Asp Ile Tyr Asp Ile Tyr Gly Thr Leu 
    290                 295                 300                 


Glu Glu Leu Gln Leu Phe Thr Val Ala Phe Glu Asn Trp Asp Ile Asn 
305                 310                 315                 320 


Arg Leu Asp Glu Leu Pro Glu Tyr Met Arg Leu Cys Phe Leu Val Ile 
                325                 330                 335     


Tyr Asn Glu Val Asn Ser Ile Ala Cys Glu Ile Leu Arg Thr Lys Asn 
            340                 345                 350         


Ile Asn Val Ile Pro Phe Leu Lys Lys Ser Trp Thr Asp Val Ser Lys 
        355                 360                 365             


Ala Tyr Leu Val Glu Ala Lys Trp Tyr Lys Ser Gly His Lys Pro Asn 
    370                 375                 380                 


Leu Glu Glu Tyr Met Gln Asn Ala Arg Ile Ser Ile Ser Ser Pro Thr 
385                 390                 395                 400 


Ile Phe Val His Phe Tyr Cys Val Phe Ser Asp Gln Leu Ser Ile Gln 
                405                 410                 415     


Val Leu Glu Thr Leu Ser Gln His Gln Gln Asn Val Val Arg Cys Ser 
            420                 425                 430         


Ser Ser Val Phe Arg Leu Ala Asn Asp Leu Val Thr Ser Pro Asp Glu 
        435                 440                 445             


Leu Ala Arg Gly Asp Val Cys Lys Ser Ile Gln Cys Tyr Met Ser Glu 
    450                 455                 460                 


Thr Gly Ala Ser Glu Asp Lys Ala Arg Ser His Val Arg Gln Met Ile 
465                 470                 475                 480 


Asn Asp Leu Trp Asp Glu Met Asn Tyr Glu Lys Met Ala His Ser Ser 
                485                 490                 495     


Ser Ile Leu His His Asp Phe Met Glu Thr Val Ile Asn Leu Ala Arg 
            500                 505                 510         


Met Ser Gln Cys Met Tyr Gln Tyr Gly Asp Gly His Gly Ser Pro Glu 
        515                 520                 525             


Lys Ala Lys Ile Val Asp Arg Val Met Ser Leu Leu Phe Asn Pro Ile 
    530                 535                 540                 


Pro Leu Asp 
545         


<210>  11
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a limonene 
       synthase obtained from Mentha spicata

<400>  11
atgcgtcgta gtggtaatta taatccatca cgttgggatg tgaactttat tcagagttta       60

ttatcagatt ataaagaaga caaacatgtc attcgtgctt cagaattagt tacactggtc      120

aagatggagt tagagaagga gacggatcag attcgtcagc tggaattgat tgatgatctt      180

caacgtatgg gtctgtcaga ccactttcag aacgaattta aagagatctt atcctccatt      240

tatcttgacc accattacta caagaaccca tttcctaaag aggaacgtga tttgtacagt      300

acctcccttg cctttcgttt attgcgtgaa cacggctttc aggttgctca ggaagtgttt      360

gattctttca agaatgaaga gggagaattt aaagaatcct tgtccgatga cactcgtggt      420

ttacttcaac tgtacgaagc atccttctta ttaaccgaag gcgagactac cttagaaagt      480

gcgcgtgaat ttgcaacgaa attcttggag gagaaggtta acgaaggcgg tgtggacggg      540

gatttactta cccgtattgc ctattctctt gatattccac tgcattggcg tattaaacgt      600

ccgaacgcac cagtttggat cgaatggtat cgtaaacgtc cagatatgaa tccggttgtc      660

ttagagttag ccattcttga tctgaacatt gtacaagccc agttccaaga ggaattgaaa      720

gaaagtttcc gttggtggcg taacacgggt ttcgtagaga aattaccatt cgcccgtgat      780

cgtttagtcg aatgttactt ctggaacacc gggattatcg agcctcgtca gcatgcgtca      840

gcccgtatta tgatgggtaa agtcaacgcc ctgattaccg ttattgatga tatttatgat      900

gtttatggta cacttgaaga gcttgagcag tttactgacc tgattcgtcg ttgggatatt      960

aattcaattg atcagctgcc ggattacatg cagttgtgct tccttgcttt gaataatttc     1020

gtagatgaca catcctacga tgtcatgaaa gagaaagggg tgaatgtcat tccttatctt     1080

cgtcaatcat gggtagattt agcagataaa tacatggttg aagctcgttg gttctacggt     1140

ggacacaaac ccagcttaga agaatacttg gagaactcat ggcaaagtat cagcggccct     1200

tgtatgttaa cccacatctt cttccgtgtt accgactcct tcactaagga aaccgtcgat     1260

tctctttata aatatcatga tctggtacgt tggtctagct ttgtgttacg tttggcagac     1320

gatcttggga catccgtcga ggaagtgtct cgtggagatg taccgaaatc attacaatgt     1380

tacatgtctg attacaacgc atccgaagct gaagcccgta agcatgtgaa gtggttaatc     1440

gcagaagtct ggaagaagat gaatgcagag cgtgtgagta aggactctcc ctttggcaaa     1500

gactttattg gatgtgctgt tgacttaggt cgtatggctc agttaatgta tcataacggt     1560

gatggtcatg gcactcagca cccgattatt caccaacaaa tgacccgtac cctgtttgaa     1620

ccgttcgca                                                             1629


<210>  12
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a limonene synthase obtained from Mentha spicata

<400>  12

Met Arg Arg Ser Gly Asn Tyr Asn Pro Ser Arg Trp Asp Val Asn Phe 
1               5                   10                  15      


Ile Gln Ser Leu Leu Ser Asp Tyr Lys Glu Asp Lys His Val Ile Arg 
            20                  25                  30          


Ala Ser Glu Leu Val Thr Leu Val Lys Met Glu Leu Glu Lys Glu Thr 
        35                  40                  45              


Asp Gln Ile Arg Gln Leu Glu Leu Ile Asp Asp Leu Gln Arg Met Gly 
    50                  55                  60                  


Leu Ser Asp His Phe Gln Asn Glu Phe Lys Glu Ile Leu Ser Ser Ile 
65                  70                  75                  80  


Tyr Leu Asp His His Tyr Tyr Lys Asn Pro Phe Pro Lys Glu Glu Arg 
                85                  90                  95      


Asp Leu Tyr Ser Thr Ser Leu Ala Phe Arg Leu Leu Arg Glu His Gly 
            100                 105                 110         


Phe Gln Val Ala Gln Glu Val Phe Asp Ser Phe Lys Asn Glu Glu Gly 
        115                 120                 125             


Glu Phe Lys Glu Ser Leu Ser Asp Asp Thr Arg Gly Leu Leu Gln Leu 
    130                 135                 140                 


Tyr Glu Ala Ser Phe Leu Leu Thr Glu Gly Glu Thr Thr Leu Glu Ser 
145                 150                 155                 160 


Ala Arg Glu Phe Ala Thr Lys Phe Leu Glu Glu Lys Val Asn Glu Gly 
                165                 170                 175     


Gly Val Asp Gly Asp Leu Leu Thr Arg Ile Ala Tyr Ser Leu Asp Ile 
            180                 185                 190         


Pro Leu His Trp Arg Ile Lys Arg Pro Asn Ala Pro Val Trp Ile Glu 
        195                 200                 205             


Trp Tyr Arg Lys Arg Pro Asp Met Asn Pro Val Val Leu Glu Leu Ala 
    210                 215                 220                 


Ile Leu Asp Leu Asn Ile Val Gln Ala Gln Phe Gln Glu Glu Leu Lys 
225                 230                 235                 240 


Glu Ser Phe Arg Trp Trp Arg Asn Thr Gly Phe Val Glu Lys Leu Pro 
                245                 250                 255     


Phe Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp Asn Thr Gly Ile 
            260                 265                 270         


Ile Glu Pro Arg Gln His Ala Ser Ala Arg Ile Met Met Gly Lys Val 
        275                 280                 285             


Asn Ala Leu Ile Thr Val Ile Asp Asp Ile Tyr Asp Val Val Gly Thr 
    290                 295                 300                 


Leu Glu Glu Leu Glu Gln Phe Thr Asp Leu Ile Arg Arg Trp Asp Ile 
305                 310                 315                 320 


Asn Ser Ile Asp Gln Leu Pro Asp Tyr Met Gln Leu Cys Phe Leu Ala 
                325                 330                 335     


Leu Asn Asn Phe Val Asp Asp Thr Ser Tyr Asp Val Met Lys Glu Lys 
            340                 345                 350         


Gly Val Asn Val Ile Pro Tyr Leu Arg Gln Ser Trp Val Asp Leu Ala 
        355                 360                 365             


Asp Lys Tyr Met Val Glu Ala Arg Trp Phe Tyr Gly Gly His Lys Pro 
    370                 375                 380                 


Ser Leu Glu Glu Tyr Leu Glu Asn Ser Trp Gln Ser Ile Ser Gly Pro 
385                 390                 395                 400 


Cys Met Leu Thr His Ile Phe Phe Arg Val Thr Asp Ser Phe Thr Lys 
                405                 410                 415     


Glu Thr Val Asp Ser Leu Tyr Lys Tyr His Asp Leu Val Arg Trp Ser 
            420                 425                 430         


Ser Phe Val Leu Arg Leu Ala Asp Asp Leu Gly Thr Ser Val Glu Glu 
        435                 440                 445             


Val Ser Arg Gly Asp Val Pro Lys Ser Leu Gln Cys Tyr Met Ser Asp 
    450                 455                 460                 


Tyr Asn Ala Ser Glu Ala Glu Ala Arg Lys His Val Lys Trp Leu Ile 
465                 470                 475                 480 


Ala Glu Val Trp Lys Lys Met Asn Ala Glu Arg Val Ser Lys Asp Ser 
                485                 490                 495     


Pro Phe Gly Lys Asp Phe Ile Gly Cys Ala Val Asp Leu Gly Arg Met 
            500                 505                 510         


Ala Gln Leu Met Tyr His Asn Gly Asp Gly His Gly Thr Gln His Pro 
        515                 520                 525             


Ile Ile His Gln Gln Met Thr Arg Thr Leu Phe Glu Pro 
    530                 535                 540     


<210>  13
<211>  1620
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a sabinene 
       synthase obtained from Salvia officinalis

<400>  13
atgcgtcgct cgggcgatta ccaaccttct ttatgggact ttaattatat ccagtctctg       60

aacaccccat ataaagagca gcgccatttc aaccgtcagg ctgaactgat tatgcaggtt      120

cgtatgctgc tgaaggtgaa gatggaagca attcagcagc tggaactgat tgacgatctg      180

cagtatctgg gtctgagcta cttctttcag gatgaaatca aacaaattct gagctctatt      240

cacaacgaac cacgctattt tcacaataac gacttgtatt tcacggcact gggtttccgc      300

attttacgcc agcatgggtt caacgtgtca gaagacgtat tcgactgttt taaaattgaa      360

aagtgctctg atttcaacgc gaacctggcc caagatacga aaggcatgct gcagctgtat      420

gaagcaagct ttttattacg tgaaggtgaa gatactttag agctggcgcg tcgcttcagc      480

acccgtagcc tgcgtgaaaa gtttgatgag ggtggtgatg aaatcgatga agatttatcc      540

agctggattc gtcattcgct ggacttaccg ttgcactggc gcgtccaagg gctggaagca      600

cgctggttcc tggatgcgta tgcccgtcgt ccggatatga atccactgat cttcaaactg      660

gcgaaattaa actttaatat tgtgcaggcc acgtaccagg aggagttaaa agatatctca      720

cgttggtgga acagtagctg cttagcggag aaattgccgt ttgtacgtga tcgcattgtg      780

gaatgttttt tttgggctat tgcggcattc gaaccacacc agtattcgta ccaacgtaaa      840

atggcggctg taattatcac ttttatcacg atcattgacg atgtctatga tgtatacggc      900

actatcgagg aactggagtt actgaccgac atgatccgtc gctgggataa taaatcgatt      960

tcgcaactgc cgtattatat gcaagtttgt tatctggctc tgtacaactt tgtatctgag     1020

cgtgcttacg atatcttaaa agaccagcac ttcaacagca tcccgtactt acagcgttcg     1080

tgggtttctt tggtagaagg gtatttaaag gaagcatatt ggtactataa cggctacaaa     1140

ccgtcgctgg aagaatacct gaataatgcg aaaatttcca tttcagctcc gactattatt     1200

agccaactgt attttaccct ggcgaatagt atcgatgaga ctgctatcga gagcttgtat     1260

cagtatcaca acatcctgta tttgtcgggg accatcttac gcctggccga cgatctgggc     1320

acttcgcaac atgagttgga gcgcggggat gtgccgaaag cgattcaatg ttacatgaac     1380

gatacaaatg cgtcggaacg cgaggcagta gaacacgtta aatttctgat ccgtgaagcg     1440

tggaaggaaa tgaacactgt taccaccgct tccgattgtc ctttcaccga tgacctggtt     1500

gctgctgccg cgaatttggc tcgtgcagcg cagttcattt acctggatgg tgacgggcat     1560

ggcgtgcagc actctgaaat tcatcagcag atgggcggcc tgctgttcca accgtacgta     1620


<210>  14
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a sabinene synthase obtained from Salvia officinalis

<400>  14

Met Arg Arg Ser Gly Asp Tyr Gln Pro Ser Leu Trp Asp Phe Asn Tyr 
1               5                   10                  15      


Ile Gln Ser Leu Asn Thr Pro Tyr Lys Glu Gln Arg His Phe Asn Arg 
            20                  25                  30          


Gln Ala Glu Leu Ile Met Gln Val Arg Met Leu Leu Lys Val Lys Met 
        35                  40                  45              


Glu Ala Ile Gln Gln Leu Glu Leu Ile Asp Asp Leu Gln Tyr Leu Gly 
    50                  55                  60                  


Leu Ser Tyr Phe Phe Gln Asp Glu Ile Lys Gln Ile Leu Ser Ser Ile 
65                  70                  75                  80  


His Asn Glu Pro Arg Tyr Phe His Asn Asn Asp Leu Tyr Phe Thr Ala 
                85                  90                  95      


Leu Gly Phe Arg Ile Leu Arg Gln His Gly Phe Asn Val Ser Glu Asp 
            100                 105                 110         


Val Phe Asp Cys Phe Lys Ile Glu Lys Cys Ser Asp Phe Asn Ala Asn 
        115                 120                 125             


Leu Ala Gln Asp Thr Lys Gly Met Leu Gln Leu Tyr Glu Ala Ser Phe 
    130                 135                 140                 


Leu Leu Arg Glu Gly Glu Asp Thr Leu Glu Leu Ala Arg Arg Phe Ser 
145                 150                 155                 160 


Thr Arg Ser Leu Arg Glu Lys Phe Asp Glu Gly Gly Asp Glu Ile Asp 
                165                 170                 175     


Glu Asp Leu Ser Ser Trp Ile Arg His Ser Leu Asp Leu Pro Leu His 
            180                 185                 190         


Trp Arg Val Gln Gly Leu Glu Ala Arg Trp Phe Leu Asp Ala Tyr Ala 
        195                 200                 205             


Arg Arg Pro Asp Met Asn Pro Leu Ile Phe Lys Leu Ala Lys Leu Asn 
    210                 215                 220                 


Phe Asn Ile Val Gln Ala Thr Tyr Gln Glu Glu Leu Lys Asp Ile Ser 
225                 230                 235                 240 


Arg Trp Trp Asn Ser Ser Cys Leu Ala Glu Lys Leu Pro Phe Val Arg 
                245                 250                 255     


Asp Arg Ile Val Glu Cys Phe Phe Trp Ala Ile Ala Ala Phe Glu Pro 
            260                 265                 270         


His Gln Tyr Ser Tyr Gln Arg Lys Met Ala Ala Val Ile Ile Thr Phe 
        275                 280                 285             


Ile Thr Ile Ile Asp Asp Val Tyr Asp Val Tyr Gly Thr Ile Glu Glu 
    290                 295                 300                 


Leu Glu Leu Leu Thr Asp Met Ile Arg Arg Trp Asp Asn Lys Ser Ile 
305                 310                 315                 320 


Ser Gln Leu Pro Tyr Tyr Met Gln Val Cys Tyr Leu Ala Leu Tyr Asn 
                325                 330                 335     


Phe Val Ser Glu Arg Ala Tyr Asp Ile Leu Lys Asp Gln His Phe Asn 
            340                 345                 350         


Ser Ile Pro Tyr Leu Gln Arg Ser Trp Val Ser Leu Val Glu Gly Tyr 
        355                 360                 365             


Leu Lys Glu Ala Tyr Trp Tyr Tyr Asn Gly Tyr Lys Pro Ser Leu Glu 
    370                 375                 380                 


Glu Tyr Leu Asn Asn Ala Lys Ile Ser Ile Ser Ala Pro Thr Ile Ile 
385                 390                 395                 400 


Ser Gln Leu Tyr Phe Thr Leu Ala Asn Ser Ile Asp Glu Thr Ala Ile 
                405                 410                 415     


Glu Ser Leu Tyr Gln Tyr His Asn Ile Leu Tyr Leu Ser Gly Thr Ile 
            420                 425                 430         


Leu Arg Leu Ala Asp Asp Leu Gly Thr Ser Gln His Glu Leu Glu Arg 
        435                 440                 445             


Gly Asp Val Pro Lys Ala Ile Gln Cys Tyr Met Asn Asp Thr Asn Ala 
    450                 455                 460                 


Ser Glu Arg Glu Ala Val Glu His Val Lys Phe Leu Ile Arg Glu Ala 
465                 470                 475                 480 


Trp Lys Glu Met Asn Thr Val Thr Thr Ala Ser Asp Cys Pro Phe Thr 
                485                 490                 495     


Asp Asp Leu Val Ala Ala Ala Ala Asn Leu Ala Arg Ala Ala Gln Phe 
            500                 505                 510         


Ile Tyr Leu Asp Gly Asp Gly His Gly Val Gln His Ser Glu Ile His 
        515                 520                 525             


Gln Gln Met Gly Gly Leu Leu Phe Gln Pro Tyr Val 
    530                 535                 540 


<210>  15
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a pinene 
       synthase obtained from Artemisia annua

<400>  15
atgcgtcgta gtgcaaatta cgccccttca ctgtggagtt atgacttcgt tcaatcgctg       60

tcctcaaaat acaaagggga taactacatg gcgcgttcgc gcgcgttgaa aggtgtagtg      120

cgcactatga tcctggaagc gaatggcatc gaaaacccat tgtcattgct gaacctggtg      180

gacgacttgc agcgcttagg catttcatac catttcctgg acgagatctc caacgttctg      240

gaaaaaatct acctgaactt ctataaaagc ccggaaaaat ggactaacat ggacttgaat      300

ttacgttctc tgggcttccg cttactgcgt caacacggtt atcatattcc tcaggaaatc      360

tttaaggatt tcatcgatgt caacggcaat tttaaaggtg atatcatcag tatgctgaat      420

ctgtatgaag cgtcgtacca ctcagtagaa gaggaatcca ttctggatga tgcccgcgaa      480

ttcaccacga aatatctgaa agagaccctg gagaacattg aagatcaaaa cattgctttg      540

ttcattagcc atgccttagt tttcccgctg cattggatgg ttccgcgcgt cgaaacgtca      600

tggtttattg aagtctaccc gaaaaaggtg ggcatgaatc cgacagtcct ggagtttgca      660

aaactggatt ttaatattct gcaagctgta catcaggagg atatgaagaa agcctcacgc      720

tggtggaaag aaacctgctg ggagaagttt ggcttcgctc gcgatcgtct ggtcgaaaac      780

tttatgtgga ccgtcgctga gaactattta ccgcactttc agaccggccg tggcgtcctg      840

acgaaagtga atgctatgat taccaccatt gacgacgttt atgatgtgta tggtactctg      900

ccagaactgg aactgtttac caacattgtt aattcttggg atatcaatgc gatcgatgaa      960

ctgccggatt atctgaaaat ttgcttcctg gcgtgttaca atgccaccaa tgaactgagc     1020

tacaacaccc tgaccaacaa aggttttttt gttcatccat acttaaaaaa agcctggcag     1080

gacttgtgca acagctatat tattgaagct aagtggttta acgatggtta cactccgacg     1140

tttaacgaat tcattgaaaa cgcttacatg tccatcggga ttgcgccgat catccgtcac     1200

gcttacctgc tgactctgac atccgtgacg gaggaagcac tgcagcacat cgaacgtgcg     1260

gaatcaatga ttcgtaacgc gtgcctgatt gtgcgtctga ctaacgacat gggtacgtca     1320

agcgacgaac tggagcgtgg tgacattcct aagagcatcc agtgctacat gcacgaatcg     1380

ggtgcaaccg aaatggaagc tcgtgcttac atcaaacagt tcattgttga aacgtggaaa     1440

aaattgaaca aggaacgtca agaaatcggt agcgaattcc cacaagaatt cgttgattgc     1500

gtaattaatc tgccgcgcat gggtcacttc atgtatacgg atggtgataa acacggtaaa     1560

ccggacatgt tcaaaccgta tgtctttagt ctgttcgtga atcctatt                  1608


<210>  16
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a pinene synthase obtained from Artemisia annua

<400>  16

Met Arg Arg Ser Ala Asn Tyr Ala Pro Ser Leu Trp Ser Tyr Asp Phe 
1               5                   10                  15      


Val Gln Ser Leu Ser Ser Lys Tyr Lys Gly Asp Asn Tyr Met Ala Arg 
            20                  25                  30          


Ser Arg Ala Leu Lys Gly Val Val Arg Thr Met Ile Leu Glu Ala Asn 
        35                  40                  45              


Gly Ile Glu Asn Pro Leu Ser Leu Leu Asn Leu Val Asp Asp Leu Gln 
    50                  55                  60                  


Arg Leu Gly Ile Ser Tyr His Phe Leu Asp Glu Ile Ser Asn Val Leu 
65                  70                  75                  80  


Glu Lys Ile Tyr Leu Asn Phe Tyr Lys Ser Pro Glu Lys Trp Thr Asn 
                85                  90                  95      


Met Asp Leu Asn Leu Arg Ser Leu Gly Phe Arg Leu Leu Arg Gln His 
            100                 105                 110         


Gly Tyr His Ile Pro Gln Glu Ile Phe Lys Asp Phe Ile Asp Val Asn 
        115                 120                 125             


Gly Asn Phe Lys Gly Asp Ile Ile Ser Met Leu Asn Leu Tyr Glu Ala 
    130                 135                 140                 


Ser Tyr His Ser Val Glu Glu Glu Ser Ile Leu Asp Asp Ala Arg Glu 
145                 150                 155                 160 


Phe Thr Thr Lys Tyr Leu Lys Glu Thr Leu Glu Asn Ile Glu Asp Gln 
                165                 170                 175     


Asn Ile Ala Leu Phe Ile Ser His Ala Leu Val Phe Pro Leu His Trp 
            180                 185                 190         


Met Val Pro Arg Val Glu Thr Ser Trp Phe Ile Glu Val Tyr Pro Lys 
        195                 200                 205             


Lys Val Gly Met Asn Pro Thr Val Leu Glu Phe Ala Lys Leu Asp Phe 
    210                 215                 220                 


Asn Ile Leu Gln Ala Val His Gln Glu Asp Met Lys Lys Ala Ser Arg 
225                 230                 235                 240 


Trp Trp Lys Glu Thr Cys Trp Glu Lys Phe Gly Phe Ala Arg Asp Arg 
                245                 250                 255     


Leu Val Glu Asn Phe Met Trp Thr Val Ala Glu Asn Tyr Leu Pro His 
            260                 265                 270         


Phe Gln Thr Gly Arg Gly Val Leu Thr Lys Val Asn Ala Met Ile Thr 
        275                 280                 285             


Thr Ile Asp Asp Val Tyr Asp Val Tyr Gly Thr Leu Pro Glu Leu Glu 
    290                 295                 300                 


Leu Phe Thr Asn Ile Val Asn Ser Trp Asp Ile Asn Ala Ile Asp Glu 
305                 310                 315                 320 


Leu Pro Asp Tyr Leu Lys Ile Cys Phe Leu Ala Cys Tyr Asn Ala Thr 
                325                 330                 335     


Asn Glu Leu Ser Tyr Asn Thr Leu Thr Asn Lys Gly Phe Phe Val His 
            340                 345                 350         


Pro Tyr Leu Lys Lys Ala Trp Gln Asp Leu Cys Asn Ser Tyr Ile Ile 
        355                 360                 365             


Glu Ala Lys Trp Phe Asn Asp Gly Tyr Thr Pro Thr Phe Asn Glu Phe 
    370                 375                 380                 


Ile Glu Asn Ala Tyr Met Ser Ile Gly Ile Ala Pro Ile Ile Arg His 
385                 390                 395                 400 


Ala Tyr Leu Leu Thr Leu Thr Ser Val Thr Glu Glu Ala Leu Gln His 
                405                 410                 415     


Ile Glu Arg Ala Glu Ser Met Ile Arg Asn Ala Cys Leu Ile Val Arg 
            420                 425                 430         


Leu Thr Asn Asp Met Gly Thr Ser Ser Asp Glu Leu Glu Arg Gly Asp 
        435                 440                 445             


Ile Pro Lys Ser Ile Gln Cys Tyr Met His Glu Ser Gly Ala Thr Glu 
    450                 455                 460                 


Met Glu Ala Arg Ala Tyr Ile Lys Gln Phe Ile Val Glu Thr Trp Lys 
465                 470                 475                 480 


Lys Leu Asn Lys Glu Arg Gln Glu Ile Gly Ser Glu Phe Pro Gln Glu 
                485                 490                 495     


Phe Val Asp Cys Val Ile Asn Leu Pro Arg Met Gly His Phe Met Tyr 
            500                 505                 510         


Thr Asp Gly Asp Lys His Gly Lys Pro Asp Met Phe Lys Pro Tyr Val 
        515                 520                 525             


Phe Ser Leu Phe Val Asn Pro Ile 
    530                 535     


<210>  17
<211>  1644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a fenchol 
       synthase obtained from Ocimym basilicum

<400>  17
atgcgtcgta gtggtaatta ccagccttcc gcctgggatt tcaattatat ccaatctctt       60

aacaataatc actccaaaga agagcgtcat ttacagggta aagctaaatt gatcgaggaa      120

gtcaagatgt tactggaaca agaaatggca gcggtacagc agctggaatt tatcgaggat      180

ttgaagaact tagggctgtc ttatttattc caagatgaga ttaagattat cttgaacagt      240

atctataacc atcacaaatg tttccacaac aaccatcagc aacgtaccga tgagaatgcg      300

gatttatact ttgtcgcatt gggtttccgt ttatttcgtc agcacggttt caaagtttct      360

caggaagtgt ttgattgctt taagaacgaa gaaggcagcg acttcattcc aaatctggcc      420

gaagatacca aaggtttgct gcaactgtat gaagcgtctt acctggtacg tcaagacgaa      480

gatactctgg agatggcgcg tcaattctcc acgaagatct tgcagaagaa agtggaagag      540

aagatgatcg aagagaacct gctgtcatgg acttgtcata gcttagaatt accgctgcac      600

tggcgtgttc aacgtattga ggctaaatgg ttcttagatg cgtatgcgag caaaccggat      660

atgaacccga ttatctttga attggccaaa ctggaattta acattgctca ggcgttacaa      720

cagggggaat taaaggatct gtctcgttgg tggaatgaca cgggcatcgc ggagaaactg      780

ccgtttgctc gtgaccgtat tgtagaagca cattattggg caattggcac gttagaacca      840

taccagtacc gttatcagcg tagtttgatc gcgaagatca ttgccctgac gactgtcgtt      900

gatgatgttt atgatgttta tggtactctg gacgaaccgc aactgtttac ggatgctatc      960

cgtcgttggg atattgaatc tattaaccaa ctgccacact atttgcaact gtgctacttg     1020

gcgatctaca actttgtcag tgaattagcg tatgatatct tccgtgataa aggtttcaat     1080

tccctgccgt atctgcataa gagttggtta gatttggttg aagcatactt cttagaagct     1140

aagtggttcc acagcggtta tacccctact ttggaagaat acctgaataa tagtaagatg     1200

acaattacat gtccggccat tgtttccgag atttacttcg cattcgcgaa cagtattgac     1260

aagacggagg tcgaatccgt gtacaaatat catgacatcc tgtacttgtc tggcatgctt     1320

ctgcgtctgc cggatgatct gggcaccact actttcgaaa tgaagcgtgg tgacgtagct     1380

aaagcgatcc agtgttacat gaaagaacac aatgccagtg aagaagaggc gcgtgaacac     1440

attcgtttcc tgatgcgtga agcctggaaa caaatgaata ccgccgccgc cgccaataac     1500

tgtccgtttg tgaatgactt tgtagtaggc gccgcgagct taggtcgtgt ggccaatttc     1560

gtttatgtgg aaggtgacgg tttcggtgta cagcactcta agatccatca acaaatggcg     1620

gaactgctgt tctacccgta tcag                                            1644


<210>  18
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a fenchol synthase obtained from Ocimym basilicum

<400>  18

Met Arg Arg Ser Gly Asn Tyr Gln Pro Ser Ala Trp Asp Phe Asn Tyr 
1               5                   10                  15      


Ile Gln Ser Leu Asn Asn Asn His Ser Lys Glu Glu Arg His Leu Gln 
            20                  25                  30          


Gly Lys Ala Lys Leu Ile Glu Glu Val Lys Met Leu Leu Glu Gln Glu 
        35                  40                  45              


Met Ala Ala Val Gln Gln Leu Glu Phe Ile Glu Asp Leu Lys Asn Leu 
    50                  55                  60                  


Gly Leu Ser Tyr Leu Phe Gln Asp Glu Ile Lys Ile Ile Leu Asn Ser 
65                  70                  75                  80  


Ile Tyr Asn His His Lys Cys Phe His Asn Asn His Gln Gln Arg Thr 
                85                  90                  95      


Asp Glu Asn Ala Asp Leu Tyr Phe Val Ala Leu Gly Phe Arg Leu Phe 
            100                 105                 110         


Arg Gln His Gly Phe Lys Val Ser Gln Glu Val Phe Asp Cys Phe Lys 
        115                 120                 125             


Asn Glu Glu Gly Ser Asp Phe Ile Pro Asn Leu Ala Glu Asp Thr Lys 
    130                 135                 140                 


Gly Leu Leu Gln Leu Tyr Glu Ala Ser Tyr Leu Val Arg Gln Asp Glu 
145                 150                 155                 160 


Asp Thr Leu Glu Met Ala Arg Gln Phe Ser Thr Lys Ile Leu Gln Lys 
                165                 170                 175     


Lys Val Glu Glu Lys Met Ile Glu Glu Asn Leu Leu Ser Trp Thr Cys 
            180                 185                 190         


His Ser Leu Glu Leu Pro Leu His Trp Arg Val Gln Arg Ile Glu Ala 
        195                 200                 205             


Lys Trp Phe Leu Asp Ala Tyr Ala Ser Lys Pro Asp Met Asn Pro Ile 
    210                 215                 220                 


Ile Phe Glu Leu Ala Lys Leu Glu Phe Asn Ile Ala Gln Ala Leu Gln 
225                 230                 235                 240 


Gln Gly Glu Leu Lys Asp Leu Ser Arg Trp Trp Asn Asp Thr Gly Ile 
                245                 250                 255     


Ala Glu Lys Leu Pro Phe Ala Arg Asp Arg Ile Val Glu Ala His Tyr 
            260                 265                 270         


Trp Ala Ile Gly Thr Leu Glu Pro Tyr Gln Tyr Arg Tyr Gln Arg Ser 
        275                 280                 285             


Leu Ile Ala Lys Ile Ile Ala Leu Thr Thr Val Val Asp Asp Val Tyr 
    290                 295                 300                 


Asp Val Tyr Gly Thr Leu Asp Glu Pro Gln Leu Phe Thr Asp Ala Ile 
305                 310                 315                 320 


Arg Arg Trp Asp Ile Glu Ser Ile Asn Gln Leu Pro His Tyr Leu Gln 
                325                 330                 335     


Leu Cys Tyr Leu Ala Ile Tyr Asn Phe Val Ser Glu Leu Ala Tyr Asp 
            340                 345                 350         


Ile Phe Arg Asp Lys Gly Phe Asn Ser Leu Pro Tyr Leu His Lys Ser 
        355                 360                 365             


Trp Leu Asp Leu Val Glu Ala Tyr Phe Leu Glu Ala Lys Trp Phe His 
    370                 375                 380                 


Ser Gly Tyr Thr Pro Thr Leu Glu Glu Tyr Leu Asn Asn Ser Lys Met 
385                 390                 395                 400 


Thr Ile Thr Cys Pro Ala Ile Val Ser Glu Ile Tyr Phe Ala Phe Ala 
                405                 410                 415     


Asn Ser Ile Asp Lys Thr Glu Val Glu Ser Val Tyr Lys Tyr His Asp 
            420                 425                 430         


Ile Leu Tyr Leu Ser Gly Met Leu Leu Arg Leu Pro Asp Asp Leu Gly 
        435                 440                 445             


Thr Thr Thr Phe Glu Met Lys Arg Gly Asp Val Ala Lys Ala Ile Gln 
    450                 455                 460                 


Cys Tyr Met Lys Glu His Asn Ala Ser Glu Glu Glu Ala Arg Glu His 
465                 470                 475                 480 


Ile Arg Phe Leu Met Arg Glu Ala Trp Lys Gln Met Asn Thr Ala Ala 
                485                 490                 495     


Ala Ala Asn Asn Cys Pro Phe Val Asn Asp Phe Val Val Gly Ala Ala 
            500                 505                 510         


Ser Leu Gly Arg Val Ala Asn Phe Val Tyr Val Glu Gly Asp Gly Phe 
        515                 520                 525             


Gly Val Gln His Ser Lys Ile His Gln Gln Met Ala Glu Leu Leu Phe 
    530                 535                 540                 


Tyr Pro Tyr Gln 
545             


<210>  19
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic codon optimized nucleotide sequence of a cineole 
       synthase obtained from Salvia fruticosa

<400>  19
atgcgtcgta ccggagggta tcaacctact ttgtgggatt tcagcactat tcaatcattt       60

gatagcgaat ataaagaaga gaaacattta atgcgtgctg cgggcatgat tgatcaggtg      120

aagatgatgc ttcaagaaga agttgattct attcgtcgtt tggaactgat tgacgatttg      180

cgtcgtctgg ggatttcatg ccactttgaa cgtgaaatcg tggaaatctt gaactccaaa      240

tattacacga acaacgaaat tgacgagcgt gatctttaca gcaccgcatt gcgattccgt      300

ttattacgtc aatacgattt cagtgttagt caggaggtgt ttgattgctt taagaacgcc      360

aaaggtacgg actttaaacc tagtttagtt gatgatactc gtggtttact tcaactgtac      420

gaagcatcct ttcttagtgc ccagggcgag gaaaccttgc gtttagcgcg tgacttcgca      480

acgaagttct tgcagaaacg tgtgctggtg gacaaagata ttaatttatt atcctctatt      540

gagcgtgcac tggaactgcc gactcactgg cgtgttcaaa tgccaaatgc acgttctttc      600

attgatgcct ataaacgtcg tccagacatg aacccaaccg tacttgaact ggcaaagttg      660

gatttcaata tggtccaagc acagtttcag caagaattaa aggaagccag tcgttggtgg      720

aacagtaccg gacttgttca tgagttgccc tttgttcgtg atcgtattgt ggagtgttac      780

tactggacga ctggcgtggt ggagcgtcgt cagcatggtt acgaacgtat catgttgacc      840

aagattaatg cactggttac gacgattgat gatgtattcg acatttatgg cacgcttgag      900

gagcttcagc tgttcaccac ggcgattcaa cgttgggaca tcgaatcaat gaagcaactg      960

ccgccttaca tgcagatctg ttaccttgct ttgtttaatt tcgtaaacga gatggcttat     1020

gacactcttc gtgataaagg cttcgattct actccttatc ttcgtaaagt ctgggtaggc     1080

ttaattgaaa gttacttgat tgaggccaaa tggtactata aaggccataa acctagttta     1140

gaagaataca tgaagaacag ttggattagt atcggcggca ttccaatctt aagtcactta     1200

ttcttccgtt tgactgactc tatcgaggaa gaagcagcag aaagtatgca caaatatcac     1260

gatattgttc gtgcaagctg cactatcttg cgtcttgccg acgatatggg gacttccctt     1320

gacgaagtgg aacgtggaga tgtaccaaag tccgtccaat gttatatgaa cgagaagaat     1380

gccagtgaag aagaggctcg tgaacacgtg cgtagcctta ttgaccaaac gtggaagatg     1440

atgaacaaag aaatgatgac gagttctttc tccaaatact tcgtcgaagt atctgctaac     1500

ttagcacgta tggcacagtg gatctaccaa catgagagtg atggctttgg tatgcaacac     1560

tccttagtga acaagatgct gcgtgactta ttatttcatc gttatgaa                  1608


<210>  20
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide encoded by codon optimized nucleotide 
       sequence of a cineole synthase obtained from Salvia fruticosa

<400>  20

Met Arg Arg Thr Gly Gly Tyr Gln Pro Thr Leu Trp Asp Phe Ser Thr 
1               5                   10                  15      


Ile Gln Ser Phe Asp Ser Glu Tyr Lys Glu Glu Lys His Leu Met Arg 
            20                  25                  30          


Ala Ala Gly Met Ile Asp Gln Val Lys Met Met Leu Gln Glu Glu Val 
        35                  40                  45              


Asp Ser Ile Arg Arg Leu Glu Leu Ile Asp Asp Leu Arg Arg Leu Gly 
    50                  55                  60                  


Ile Ser Cys His Phe Glu Arg Glu Ile Val Glu Ile Leu Asn Ser Lys 
65                  70                  75                  80  


Tyr Tyr Thr Asn Asn Glu Ile Asp Glu Arg Asp Leu Tyr Ser Thr Ala 
                85                  90                  95      


Leu Arg Phe Arg Leu Leu Arg Gln Tyr Asp Phe Ser Val Ser Gln Glu 
            100                 105                 110         


Val Phe Asp Cys Phe Lys Asn Ala Lys Gly Thr Asp Phe Lys Pro Ser 
        115                 120                 125             


Leu Val Asp Asp Thr Arg Gly Leu Leu Gln Leu Tyr Glu Ala Ser Phe 
    130                 135                 140                 


Leu Ser Ala Gln Gly Glu Glu Thr Leu Arg Leu Ala Arg Asp Phe Ala 
145                 150                 155                 160 


Thr Lys Phe Leu Gln Lys Arg Val Leu Val Asp Lys Asp Ile Asn Leu 
                165                 170                 175     


Leu Ser Ser Ile Glu Arg Ala Leu Glu Leu Pro Thr His Trp Arg Val 
            180                 185                 190         


Gln Met Pro Asn Ala Arg Ser Phe Ile Asp Ala Tyr Lys Arg Arg Pro 
        195                 200                 205             


Asp Met Asn Pro Thr Val Leu Glu Leu Ala Lys Leu Asp Phe Asn Met 
    210                 215                 220                 


Val Gln Ala Gln Phe Gln Gln Glu Leu Lys Glu Ala Ser Arg Trp Trp 
225                 230                 235                 240 


Asn Ser Thr Gly Leu Val His Glu Leu Pro Phe Val Arg Asp Arg Ile 
                245                 250                 255     


Val Glu Cys Tyr Tyr Trp Thr Thr Gly Val Val Glu Arg Arg Gln His 
            260                 265                 270         


Gly Tyr Glu Arg Ile Met Leu Thr Lys Ile Asn Ala Leu Val Thr Thr 
        275                 280                 285             


Ile Asp Asp Val Phe Asp Ile Tyr Gly Thr Leu Glu Glu Leu Gln Leu 
    290                 295                 300                 


Phe Thr Thr Ala Ile Gln Arg Trp Asp Ile Glu Ser Met Lys Gln Leu 
305                 310                 315                 320 


Pro Pro Tyr Met Gln Ile Cys Tyr Leu Ala Leu Phe Asn Phe Val Asn 
                325                 330                 335     


Glu Met Ala Tyr Asp Thr Leu Arg Asp Lys Gly Phe Asp Ser Thr Pro 
            340                 345                 350         


Tyr Leu Arg Lys Val Trp Val Gly Leu Ile Glu Ser Tyr Leu Ile Glu 
        355                 360                 365             


Ala Lys Trp Tyr Tyr Lys Gly His Lys Pro Ser Leu Glu Glu Tyr Met 
    370                 375                 380                 


Lys Asn Ser Trp Ile Ser Ile Gly Gly Ile Pro Ile Leu Ser His Leu 
385                 390                 395                 400 


Phe Phe Arg Leu Thr Asp Ser Ile Glu Glu Glu Ala Ala Glu Ser Met 
                405                 410                 415     


His Lys Tyr His Asp Ile Val Arg Ala Ser Cys Thr Ile Leu Arg Leu 
            420                 425                 430         


Ala Asp Asp Met Gly Thr Ser Leu Asp Glu Val Glu Arg Gly Asp Val 
        435                 440                 445             


Pro Lys Ser Val Gln Cys Tyr Met Asn Glu Lys Asn Ala Ser Glu Glu 
    450                 455                 460                 


Glu Ala Arg Glu His Val Arg Ser Leu Ile Asp Gln Thr Trp Lys Met 
465                 470                 475                 480 


Met Asn Lys Glu Met Met Thr Ser Ser Phe Ser Lys Tyr Phe Val Glu 
                485                 490                 495     


Val Ser Ala Asn Leu Ala Arg Met Ala Gln Trp Ile Tyr Gln His Glu 
            500                 505                 510         


Ser Asp Gly Phe Gly Met Gln His Ser Leu Val Asn Lys Met Leu Arg 
        515                 520                 525             


Asp Leu Leu Phe His Arg Tyr Glu 
    530                 535     


<210>  21
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
gaattcataa gcttgtgagc ggccgcattg atgcatagct agcaggccgg ccaggtacca       60

c                                                                       61


<210>  22
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
cccgggtggt acctggccgg cctgctagct atgcatcaat gcggccgctc acaagcttat       60

g                                                                       61


