                         SEQUENCE LISTING

<110>  Codexis, Inc.
       Alvizo, Oscar
       McDaniel, Robert
       Mijts, Benjamin
 
<120>  Production of Geranyl Diphosphate

<130>  90834-799243

<140>  PCT/US2011/030590
<141>  2011-03-30

<150>  US 61/319,586
<151>  2010-03-31

<150>  US 61/319,560
<151>  2010-03-31

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  900
<212>  DNA
<213>  Escherichia coli

<400>  1
atggactttc cgcagcaact cgaagcctgc gttaagcagg ccaaccaggc gctgagccgt       60

tttatcgccc cactgccctt tcagaacact cccgtggtcg aaaccatgca gtatggcgca      120

ttattaggtg gtaagcgcct gcgacctttc ctggtttatg ccaccggtca tatgttcggc      180

gttagcacaa acacgctgga cgcacccgct gccgccgttg agtgtatcca cgcttactca      240

ttaattcatg atgatttacc ggcaatggat gatgacgatc tgcgtcgcgg tttgccaacc      300

tgccatgtga agtttggcga agcaaacgcg attctcgctg gcgacgcttt acaaacgctg      360

gcgttctcga ttttaagcga tgccgatatg ccggaagtgt cggaccgcga cagaatttcg      420

atgatttctg aactggcgag cgccagtggt attgccggaa tgtgcggtgg tcaggcatta      480

gatttagacg cggaaggcaa acacgtacct ctggacgcgc ttgagcgtat tcatcgtcat      540

aaaaccggcg cattgattcg cgccgccgtt cgccttggtg cattaagcgc cggagataaa      600

ggacgtcgtg ctctgccggt actcgacaag tatgcagaga gcatcggcct tgccttccag      660

gttcaggatg acatcctgga tgtggtggga gatactgcaa cgttgggaaa acgccagggt      720

gccgaccagc aacttggtaa aagtacctac cctgcacttc tgggtcttga gcaagcccgg      780

aagaaagccc gggatctgat cgacgatgcc cgtcagtcgc tgaaacaact ggctgaacag      840

tcactcgata cctcggcact ggaagcgcta gcggactaca tcatccagcg taataaataa      900


<210>  2
<211>  299
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Asp Phe Pro Gln Gln Leu Glu Ala Cys Val Lys Gln Ala Asn Gln 
1               5                   10                  15      


Ala Leu Ser Arg Phe Ile Ala Pro Leu Pro Phe Gln Asn Thr Pro Val 
            20                  25                  30          


Val Glu Thr Met Gln Tyr Gly Ala Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly His Met Phe Gly Val Ser Thr Asn 
    50                  55                  60                  


Thr Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr Ser 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Leu Pro Thr Cys His Val Lys Phe Gly Glu Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ser Asp Ala 
        115                 120                 125             


Asp Met Pro Glu Val Ser Asp Arg Asp Arg Ile Ser Met Ile Ser Glu 
    130                 135                 140                 


Leu Ala Ser Ala Ser Gly Ile Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Asp Ala Glu Gly Lys His Val Pro Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Leu 
            180                 185                 190         


Gly Ala Leu Ser Ala Gly Asp Lys Gly Arg Arg Ala Leu Pro Val Leu 
        195                 200                 205             


Asp Lys Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Arg Lys Lys Ala Arg Asp Leu Ile Asp Asp Ala Arg Gln 
            260                 265                 270         


Ser Leu Lys Gln Leu Ala Glu Gln Ser Leu Asp Thr Ser Ala Leu Glu 
        275                 280                 285             


Ala Leu Ala Asp Tyr Ile Ile Gln Arg Asn Lys 
    290                 295                 


<210>  3
<211>  299
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of S80F variant of WT IspA from Escherichia
       coli

<400>  3

Met Asp Phe Pro Gln Gln Leu Glu Ala Cys Val Lys Gln Ala Asn Gln 
1               5                   10                  15      


Ala Leu Ser Arg Phe Ile Ala Pro Leu Pro Phe Gln Asn Thr Pro Val 
            20                  25                  30          


Val Glu Thr Met Gln Tyr Gly Ala Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly His Met Phe Gly Val Ser Thr Asn 
    50                  55                  60                  


Thr Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr Phe 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Leu Pro Thr Cys His Val Lys Phe Gly Glu Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ser Asp Ala 
        115                 120                 125             


Asp Met Pro Glu Val Ser Asp Arg Asp Arg Ile Ser Met Ile Ser Glu 
    130                 135                 140                 


Leu Ala Ser Ala Ser Gly Ile Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Asp Ala Glu Gly Lys His Val Pro Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Leu 
            180                 185                 190         


Gly Ala Leu Ser Ala Gly Asp Lys Gly Arg Arg Ala Leu Pro Val Leu 
        195                 200                 205             


Asp Lys Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Arg Lys Lys Ala Arg Asp Leu Ile Asp Asp Ala Arg Gln 
            260                 265                 270         


Ser Leu Lys Gln Leu Ala Glu Gln Ser Leu Asp Thr Ser Ala Leu Glu 
        275                 280                 285             


Ala Leu Ala Asp Tyr Ile Ile Gln Arg Asn Lys 
    290                 295                 


<210>  4
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
gaattcataa gcttgtgagc ggccgcattg atgcatagct agcaggccgg ccaggtacca       60

c                                                                       61


<210>  5
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
cccgggtggt acctggccgg cctgctagct atgcatcaat gcggccgctc acaagcttat       60

g                                                                       61


<210>  6
<211>  367
<212>  PRT
<213>  Gallus gallus

<400>  6

Met His Lys Phe Thr Gly Val Asn Ala Lys Phe Gln Gln Pro Ala Leu 
1               5                   10                  15      


Arg Asn Leu Ser Pro Val Val Val Glu Arg Glu Arg Glu Glu Phe Val 
            20                  25                  30          


Gly Phe Phe Pro Gln Ile Val Arg Asp Leu Thr Glu Asp Gly Ile Gly 
        35                  40                  45              


His Pro Glu Val Gly Asp Ala Val Ala Arg Leu Lys Glu Val Leu Gln 
    50                  55                  60                  


Tyr Asn Ala Pro Gly Gly Lys Cys Asn Arg Gly Leu Thr Val Val Ala 
65                  70                  75                  80  


Ala Tyr Arg Glu Leu Ser Gly Pro Gly Gln Lys Asp Ala Glu Ser Leu 
                85                  90                  95      


Arg Cys Ala Leu Ala Val Gly Trp Cys Ile Glu Leu Phe Gln Ala Phe 
            100                 105                 110         


Phe Leu Val Ala Asp Asp Ile Met Asp Gln Ser Leu Thr Arg Arg Gly 
        115                 120                 125             


Gln Leu Cys Trp Tyr Lys Lys Glu Gly Val Gly Leu Asp Ala Ile Asn 
    130                 135                 140                 


Asp Ser Phe Leu Leu Glu Ser Ser Val Tyr Arg Val Leu Lys Lys Tyr 
145                 150                 155                 160 


Cys Arg Gln Arg Pro Tyr Tyr Val His Leu Leu Glu Leu Phe Leu Gln 
                165                 170                 175     


Thr Ala Tyr Gln Thr Glu Leu Gly Gln Met Leu Asp Leu Ile Thr Ala 
            180                 185                 190         


Pro Val Ser Lys Val Asp Leu Ser His Phe Ser Glu Glu Arg Tyr Lys 
        195                 200                 205             


Ala Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu Pro Val 
    210                 215                 220                 


Ala Ala Ala Met Tyr Met Val Gly Ile Asp Ser Lys Glu Glu His Glu 
225                 230                 235                 240 


Asn Ala Lys Ala Ile Leu Leu Glu Met Gly Glu Tyr Phe Gln Ile Gln 
                245                 250                 255     


Asp Asp Tyr Leu Asp Cys Phe Gly Asp Pro Ala Leu Thr Gly Lys Val 
            260                 265                 270         


Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val Gln Cys 
        275                 280                 285             


Leu Gln Arg Val Thr Pro Glu Gln Arg Gln Leu Leu Glu Asp Asn Tyr 
    290                 295                 300                 


Gly Arg Lys Glu Pro Glu Lys Val Ala Lys Val Lys Glu Leu Tyr Glu 
305                 310                 315                 320 


Ala Val Gly Met Arg Ala Ala Phe Gln Gln Tyr Glu Glu Ser Ser Tyr 
                325                 330                 335     


Arg Arg Leu Gln Glu Leu Ile Glu Lys His Ser Asn Arg Leu Pro Lys 
            340                 345                 350         


Glu Ile Phe Leu Gly Leu Ala Gln Lys Ile Tyr Lys Arg Gln Lys 
        355                 360                 365         


<210>  7
<211>  299
<212>  PRT
<213>  Salmonela enterica

<400>  7

Met Asp Phe Thr Gln Gln Leu Gln Ala Cys Val Thr Gln Ala Asn Gln 
1               5                   10                  15      


Ala Leu Ser Arg Phe Ile Ala Pro Leu Pro Phe Gln Asn Thr Pro Val 
            20                  25                  30          


Val Glu Ala Met Gln Tyr Gly Ala Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly Gln Met Phe Gly Val Ser Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr Ser 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Leu Pro Thr Cys His Ile Lys Phe Gly Glu Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Ala Leu Ala Phe Ala Ile Ile Ser Asp Ala 
        115                 120                 125             


Pro Met Pro Glu Val Ala Asp Arg Asp Arg Ile Ala Met Ile Ala Glu 
    130                 135                 140                 


Leu Ala Asn Ala Ser Gly Ile Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Ala Ala Glu Gly Gln Arg Ile Thr Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Leu 
            180                 185                 190         


Gly Ala Leu Ser Ala Gly Asp Lys Gly Arg Asn Thr Leu Pro Ile Leu 
        195                 200                 205             


Asp Arg Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Arg Asn Lys Ala Arg Asp Leu Ile Glu Asp Ala Arg Gln 
            260                 265                 270         


Ser Leu His Gln Leu Ala Ala Gln Ser Leu Asp Thr Ser Ala Leu Glu 
        275                 280                 285             


Ala Leu Ala Asn Tyr Ile Ile Gln Arg Asp Lys 
    290                 295                 


<210>  8
<211>  299
<212>  PRT
<213>  Cronobacter turicensis

<400>  8

Met Asp Phe Ser Gln Gln Leu Gln Ser Gln Ala Glu Arg Ala Asn Ser 
1               5                   10                  15      


Ala Leu Gln His Phe Ile Gly Ala Leu Pro Phe Gln Lys Ser Pro Leu 
            20                  25                  30          


Val Glu Ala Met Leu Tyr Gly Thr Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly Glu Met Phe Gly Val Asn Pro Thr 
    50                  55                  60                  


Ala Leu Asp Ala Pro Ala Ala Ala Ile Glu Cys Ile His Ala Tyr Ser 
65                  70                  75                  80  


Leu Met His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Gln Pro Thr Cys His Ile Arg Phe Gly Glu Ala Ser Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ser Asp Ala 
        115                 120                 125             


Pro Met Glu Asn Val Ala Leu Arg Asp Arg Leu Ala Met Val Ser Glu 
    130                 135                 140                 


Leu Ala Lys Ala Ser Gly Val Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Glu Ala Glu Gly Gln Gln Val Asp Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Met 
            180                 185                 190         


Gly Ala Leu Cys Ala Gly Asp Lys Gly Arg Asp Ala Leu Val Tyr Leu 
        195                 200                 205             


Asp Ser Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Gln Ala Lys Ala Arg Ser Leu Cys Asp Asp Ala Leu Ala 
            260                 265                 270         


Ala Leu Ala Pro Leu Lys Ala Gln Ala Leu Asp Thr Ala Thr Leu Glu 
        275                 280                 285             


Ala Leu Ala Asn Phe Ile Ile Gln Arg Asp Lys 
    290                 295                 


<210>  9
<211>  303
<212>  PRT
<213>  Pectobacterium astrosepticum

<400>  9

Met Thr Asp Phe Ser Ala Gln Leu Asn Ala His Tyr Gln Arg Thr Asn 
1               5                   10                  15      


Arg Met Leu Gly His Phe Ile Thr Ser Leu Pro Phe Gln Ser Ser Pro 
            20                  25                  30          


Leu Val Asn Ala Met Glu Tyr Gly Ser Leu Leu Gly Gly Lys Arg Leu 
        35                  40                  45              


Arg Pro Phe Leu Val Tyr Thr Thr Gly Glu Leu Phe Asp Met Pro Leu 
    50                  55                  60                  


Glu Ser Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr 
65                  70                  75                  80  


Ser Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg 
                85                  90                  95      


Arg Gly Gln Pro Thr Cys His Ile Lys Phe Gly Glu Ala Thr Ala Ile 
            100                 105                 110         


Leu Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ala Asp 
        115                 120                 125             


Ala Pro Met Thr Gln Val Ser Asp Arg Asp Arg Leu Ala Met Ile Ser 
    130                 135                 140                 


Glu Leu Ala Gln Ala Ser Gly Val Ala Gly Met Cys Gly Gly Gln Ala 
145                 150                 155                 160 


Phe Asp Leu Glu Ala Glu Gly His Gln Val Asn Leu Ala Ala Leu Glu 
                165                 170                 175     


Arg Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg 
            180                 185                 190         


Leu Gly Ala Leu Ala Ala Gly Asp Ala Gly Arg Asp Ala Leu Pro Tyr 
        195                 200                 205             


Leu Asp Arg Tyr Ala Asn Ala Ile Gly Leu Ala Phe Gln Val Gln Asp 
    210                 215                 220                 


Asp Ile Leu Asp Val Val Gly Asp Ser Ala Thr Thr Gly Lys Arg Gln 
225                 230                 235                 240 


Gly Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ser Leu Leu Gly 
                245                 250                 255     


Leu Asp Asn Ala Arg Lys Lys Ala Gln Glu Leu Tyr Gln Glu Ser Leu 
            260                 265                 270         


Ala Ser Leu Asp Asp Leu Val Ala Ser Ser Pro Ile Pro Leu Asn Ile 
        275                 280                 285             


Ala Pro Leu Gln Ala Leu Ala Asn Phe Ile Val Glu Arg Asp Lys 
    290                 295                 300             


<210>  10
<211>  312
<212>  PRT
<213>  Candidatus hamiltonella

<400>  10

Met Pro Asp Lys Ile Ser Phe Ser Asp Gln His Thr Ser Phe Asp Phe 
1               5                   10                  15      


Asp Gln Gln Leu Ser Lys Tyr Gln Lys Arg Val Glu Thr Tyr Leu Ser 
            20                  25                  30          


Ser Ala Leu Asp Lys Leu Pro Ala Tyr Asn Thr Val Leu Leu Asp Val 
        35                  40                  45              


Met Arg Tyr Ser Thr Leu Met Gly Gly Lys Arg Leu Arg Pro Tyr Leu 
    50                  55                  60                  


Val Tyr Ala Thr Gly Gln Met Leu Gly Leu Ser Leu Ser Asn Leu Asp 
65                  70                  75                  80  


Ala Pro Ala Ala Ala Ile Glu Cys Ile His Ser Tyr Ser Leu Leu His 
                85                  90                  95      


Asp Asp Leu Pro Ser Met Asp Asn Asp Asp Leu Arg Arg Gly Glu Leu 
            100                 105                 110         


Thr Gly His Val Lys Phe Gly Glu Ala Asn Ala Ile Leu Ala Gly Asp 
        115                 120                 125             


Ser Leu Gln Ser Leu Ala Phe Ser Ile Leu Ala Asp Asp Arg Met Pro 
    130                 135                 140                 


Asp Val Val Thr Glu Asp Arg Leu Ala Met Leu Ser Glu Leu Ala Arg 
145                 150                 155                 160 


Ala Ser Gly Ala Thr Gly Met Cys Gly Gly Gln Ala Leu Asp Met Ala 
                165                 170                 175     


Ser Glu Tyr Leu Asp Ile Ser Leu Glu Thr Leu Glu Leu Ile His His 
            180                 185                 190         


His Lys Thr Gly Ala Leu Leu Arg Ala Ala Val Arg Leu Gly Ala Leu 
        195                 200                 205             


Ala Ala Gly Glu Thr Gly Arg Lys Ala Leu Pro Trp Leu Asp Gln Tyr 
    210                 215                 220                 


Ala Lys Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp Ile Leu Asp 
225                 230                 235                 240 


Glu Ile Gly Glu Ala Arg Lys Thr Gly Lys Lys Pro Lys Ser Asp Gln 
                245                 250                 255     


Gln Arg Gly Lys Ala Thr Tyr Pro Gly Leu Leu Ser Leu Lys Gly Ala 
            260                 265                 270         


Gln Lys Lys Met Ala Ala Leu Tyr Gln Ser Ser Leu Ser Ala Leu Thr 
        275                 280                 285             


Val Pro Glu Ala Ser Val Tyr Asn Thr Leu Pro Leu Gln Ala Cys Ala 
    290                 295                 300                 


His Phe Ile Leu Glu Arg His Tyr 
305                 310         


<210>  11
<211>  297
<212>  PRT
<213>  Laribacter hongkongensis

<400>  11

Met Thr Asp Thr Asp Phe Leu Arg Trp Met Thr Asp Ile Gln Gln His 
1               5                   10                  15      


Val Glu Thr Ala Leu Ala Ala Ser Leu Pro Ala Gly Thr His Ala Ala 
            20                  25                  30          


Thr Pro Leu Phe Asp Ala Met Arg Tyr Ala Ala Leu Asp Gly Gly Lys 
        35                  40                  45              


Arg Val Arg Pro Leu Leu Val Phe Ala Ala Gly Asp Val Ser Gly Ala 
    50                  55                  60                  


Thr Pro Glu Ala Leu Ser Ala Ala Ala Cys Ala Val Glu Cys Ile His 
65                  70                  75                  80  


Ala Tyr Ser Leu Val His Asp Asp Leu Pro Cys Met Asp Asp Asp Val 
                85                  90                  95      


Leu Arg Arg Gly Lys Pro Thr Cys His Ile Ala His Gly Glu Ala Met 
            100                 105                 110         


Ala Leu Leu Ala Gly Asp Ala Leu Gln Ala His Ala Phe Glu Leu Leu 
        115                 120                 125             


Ala Ile Pro Leu Pro Gly Val Val Pro Ala Arg Gln Leu Ala Met Val 
    130                 135                 140                 


Ser Ala Leu Ala His Ala Ala Gly Pro Arg Gly Met Cys Gly Gly Gln 
145                 150                 155                 160 


Ala Ile Asp Leu Ala Ala Val Gly His Ala Leu Asp Gln Thr Ala Leu 
                165                 170                 175     


Glu Tyr Met His Cys Leu Lys Thr Gly Ala Leu Ile Gln Ala Ala Val 
            180                 185                 190         


Arg Leu Gly Ala Leu Ala Gly Ser Pro Asp Asp Asp Glu Leu Ala Ala 
        195                 200                 205             


Leu Asp Arg Tyr Ala Arg Arg Ile Gly Leu Ala Phe Gln Val Ile Asp 
    210                 215                 220                 


Asp Val Leu Asp Cys Glu Ala Asp Ser Ala Thr Leu Gly Lys Thr Ala 
225                 230                 235                 240 


Gly Lys Asp Ala Ala His Asp Lys Pro Thr Tyr Val Ser Leu Met Gly 
                245                 250                 255     


Leu Gly Glu Ala Arg Ser Tyr Ala His Ala Leu Leu Ala Asp Ala His 
            260                 265                 270         


Glu Ala Leu Ala Leu Phe Gly Ala Arg Ala Arg Arg Leu Gln Gln Leu 
        275                 280                 285             


Ala Asp Tyr Ile Val Ala Arg Ser Phe 
    290                 295         


<210>  12
<211>  295
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  12

Met Ile Ala Ala Tyr Gln Ala Arg Cys Gln Ala Arg Val Asp Ala Ala 
1               5                   10                  15      


Leu Asp Ala Leu Phe Val Ala Pro Arg Glu Glu Leu Gln Arg Leu Tyr 
            20                  25                  30          


Glu Ala Met Arg Tyr Ser Val Met Asn Gly Gly Lys Arg Val Arg Pro 
        35                  40                  45              


Leu Leu Ala Tyr Ala Ala Cys Glu Ala Leu Gly Gly Ala Pro Gln Arg 
    50                  55                  60                  


Ala Asp Ala Ala Ala Cys Ala Val Glu Leu Ile His Ala Tyr Ser Leu 
65                  70                  75                  80  


Val His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg Gly 
                85                  90                  95      


Gln Pro Thr Thr His Arg Ala Phe Asp Glu Ala Thr Ala Ile Leu Ala 
            100                 105                 110         


Ala Asp Gly Leu Gln Ala Leu Ala Phe Glu Val Leu Ala Asp Thr Arg 
        115                 120                 125             


Arg Asn Pro Gln Glu His Ala Val Cys Leu Glu Met Leu Thr Arg Leu 
    130                 135                 140                 


Ala Arg Ala Ala Gly Ser Ala Gly Met Val Gly Gly Gln Ala Ile Asp 
145                 150                 155                 160 


Leu Gly Ser Val Gly Val Ala Leu Asp Gln Ala Ala Leu Glu Val Met 
                165                 170                 175     


His Arg His Lys Thr Gly Ala Leu Ile Glu Ala Ser Val Arg Leu Gly 
            180                 185                 190         


Ala Leu Ala Ser Gly Arg Ala Glu Pro Ala Ser Leu Ala Ala Leu Glu 
        195                 200                 205             


Arg Tyr Ala Glu Ala Ile Gly Leu Ala Phe Gln Val Gln Asp Asp Ile 
    210                 215                 220                 


Leu Asp Val Glu Ser Asp Thr Ala Thr Leu Gly Lys Thr Gln Gly Lys 
225                 230                 235                 240 


Asp Gln Ala His Asn Lys Pro Thr Tyr Pro Ala Leu Leu Gly Leu Glu 
                245                 250                 255     


Ala Ala Lys Gly Tyr Ala Leu Glu Leu Arg Asp Leu Ala Leu Ala Ala 
            260                 265                 270         


Leu Asp Gly Phe Pro Pro Ser Ala Asp Pro Leu Arg Gln Leu Ala Arg 
        275                 280                 285             


Tyr Ile Val Glu Arg Arg Asn 
    290                 295 


<210>  13
<211>  300
<212>  PRT
<213>  Mannheimia succiniciproducens

<400>  13

Met Met Arg Leu Met Tyr Gln Phe Ser Asn Asp Leu Gln Gln Ala Gln 
1               5                   10                  15      


Gln Arg Ile Asn Arg Phe Leu Glu Ala Gln Phe Asp Glu Ile Asn Thr 
            20                  25                  30          


Arg Pro Ser Pro Leu Ala Asp Ala Met Lys Tyr Gly Leu Leu Leu Gly 
        35                  40                  45              


Gly Lys Arg Ile Arg Pro Phe Leu Val Tyr Ala Thr Gly Arg Met Leu 
    50                  55                  60                  


Gly Ala Asp Thr Ala Gln Leu Asp Tyr Ala Ala Ala Ala Ile Glu Ala 
65                  70                  75                  80  


Ile His Ala Tyr Ser Leu Ile His Asp Asp Leu Pro Ala Met Asp Asn 
                85                  90                  95      


Asp Ser Leu Arg Arg Gly Gln Pro Thr Cys His Ile Ala Phe Asp His 
            100                 105                 110         


Ala Thr Ala Ile Leu Ala Gly Asp Ala Leu Gln Ala Phe Ala Phe Glu 
        115                 120                 125             


Ile Leu Thr Lys Ser Thr Ala Leu Ser Ala Glu Gln Lys Leu Arg Leu 
    130                 135                 140                 


Ile Gln Val Leu Ser His Asn Ser Gly Val Phe Gly Met Cys Leu Gly 
145                 150                 155                 160 


Gln Ser Leu Asp Leu Ile Ser Glu His Lys Gln Ile Ser Leu Ser Glu 
                165                 170                 175     


Leu Glu Gln Ile His Arg Asn Lys Thr Gly Ala Leu Leu Ser Ala Ala 
            180                 185                 190         


Leu Lys Met Gly Phe Ile Cys Ser Ser His Phe Ala Asp Asn Ala Leu 
        195                 200                 205             


Glu Ala Lys Leu Asp Arg Tyr Ala Ala Ala Ile Gly Leu Ala Phe Gln 
    210                 215                 220                 


Val Gln Asp Asp Ile Leu Asp Ile Glu Gly Asp Leu Ala Ala Ile Gly 
225                 230                 235                 240 


Lys Asn Val Gly Ser Asp Leu Glu Ser Asp Lys Ser Thr Tyr Pro Lys 
                245                 250                 255     


Leu Leu Gly Leu Ala Gly Ala Lys Gln Lys Ala Arg Glu Leu Tyr Val 
            260                 265                 270         


Ala Ala Val Gly Glu Leu Glu His Leu Pro Phe Asp Thr Thr Ala Leu 
        275                 280                 285             


Arg Ala Leu Ala Glu Phe Ile Ile Asn Arg Lys Asn 
    290                 295                 300 


<210>  14
<211>  295
<212>  PRT
<213>  Pasteurella multocida

<400>  14

Met Tyr Gln Leu Ser Gln Asp Leu Pro Gln Leu Gln Gln Arg Ile Asn 
1               5                   10                  15      


Thr Phe Leu Ala Gln Gln Leu Asn Val Asp Ser Ser Pro Ser Pro Leu 
            20                  25                  30          


Ala Glu Ala Met Arg Tyr Gly Val Leu Leu Gly Gly Lys Arg Ile Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly Arg Met Leu Gly Ala Asp Leu Asn 
    50                  55                  60                  


Gln Leu Asp Tyr Ala Ala Ala Ser Val Glu Ala Val His Ala Tyr Ser 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp His Leu Arg Arg 
                85                  90                  95      


Gly Gln Pro Thr Cys His Ile Ala Phe Asp His Ala Thr Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Ala Phe Ala Phe Glu Ile Leu Thr Gln Ala 
        115                 120                 125             


Pro Ala Leu Gln Ala Glu Gln Lys Leu Ala Leu Val Gln Thr Leu Ser 
    130                 135                 140                 


Gln Ala Ala Gly Val Lys Gly Met Cys Leu Gly Gln Ser Leu Asp Leu 
145                 150                 155                 160 


Ile Ser Glu Gln Lys His Ile Ser Leu Ile Glu Leu Glu Gln Ile His 
                165                 170                 175     


Arg Asn Lys Thr Gly Ala Met Leu Ser Ala Ala Ile Gln Leu Gly Arg 
            180                 185                 190         


Ile Cys Ser Pro His Phe Lys Asn Asp Thr Leu Ala Gln Gln Leu Gln 
        195                 200                 205             


Arg Tyr Ser Glu Ala Ile Gly Leu Ala Phe Gln Val Gln Asp Asp Ile 
    210                 215                 220                 


Leu Asp Ile Glu Gly Glu Ser Asp Ile Ile Gly Lys Thr Val Gly Ser 
225                 230                 235                 240 


Asp Leu Leu Ala Asp Lys Ser Thr Tyr Pro Lys Leu Leu Gly Leu Ala 
                245                 250                 255     


Gly Ala Lys Gln Lys Ala Gln Glu Leu Tyr Gln Asn Ala Ile Ala Glu 
            260                 265                 270         


Leu Glu Ser Ile Pro Phe Asp Thr Ser Ala Leu Arg Ala Ile Ala Glu 
        275                 280                 285             


Phe Val Val Asn Arg Lys Ser 
    290                 295 


