-                         SEQUENCE LISTING

<110>  Micromet AG
 
<120>  Cross-species-specific PSMAxCD3 bispecific single chain antibody

<130>  MIM 13602PCT

<150>  US 61/320,052
<151>  2010-04-01

<160>  633   

<170>  PatentIn version 3.5

<210>  1
<211>  105
<212>  PRT
<213>  human

<400>  1

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp 
            100                 105 


<210>  2
<211>  27
<212>  PRT
<213>  human

<400>  2

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
            20                  25          


<210>  3
<211>  96
<212>  PRT
<213>  Callithrix jacchus

<400>  3

Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Cys Pro Arg Tyr Asp 
            20                  25                  30          


Gly His Glu Ile Lys Trp Leu Val Asn Ser Gln Asn Lys Glu Gly His 
        35                  40                  45              


Glu Asp His Leu Leu Leu Glu Asp Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  


Tyr Tyr Ala Cys Leu Ser Lys Glu Thr Pro Ala Glu Glu Ala Ser His 
65                  70                  75                  80  


Tyr Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val Glu Val Asp 
                85                  90                  95      


<210>  4
<211>  27
<212>  PRT
<213>  Callithrix jacchus

<400>  4

Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr 
            20                  25          


<210>  5
<211>  96
<212>  PRT
<213>  Saguinus oedipus

<400>  5

Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Cys Pro Arg Tyr Asp 
            20                  25                  30          


Gly His Glu Ile Lys Trp Leu Val Asn Ser Gln Asn Lys Glu Gly His 
        35                  40                  45              


Glu Asp His Leu Leu Leu Glu Asp Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  


Tyr Tyr Ala Cys Leu Ser Lys Glu Thr Pro Ala Glu Glu Ala Ser His 
65                  70                  75                  80  


Tyr Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val Glu Val Asp 
                85                  90                  95      


<210>  6
<211>  27
<212>  PRT
<213>  Saguinus oedipus

<400>  6

Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr 
            20                  25          


<210>  7
<211>  96
<212>  PRT
<213>  Saimiri sciureus

<400>  7

Gln Asp Gly Asn Glu Glu Ile Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Cys Pro Arg Tyr Asp 
            20                  25                  30          


Gly Gln Glu Ile Lys Trp Leu Val Asn Asp Gln Asn Lys Glu Gly His 
        35                  40                  45              


Glu Asp His Leu Leu Leu Glu Asp Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  


Tyr Tyr Ala Cys Leu Ser Lys Glu Thr Pro Thr Glu Glu Ala Ser His 
65                  70                  75                  80  


Tyr Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val Glu Val Asp 
                85                  90                  95      


<210>  8
<211>  27
<212>  PRT
<213>  Saimiri sciureus

<400>  8

Gln Asp Gly Asn Glu Glu Ile Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr 
            20                  25          


<210>  9
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of F6A

<400>  9

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  10
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of F6A

<400>  10

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of F6A

<400>  11

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  12
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of F6A

<400>  12

Ile Tyr Ala Met Asn 
1               5   


<210>  13
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of F6A

<400>  13

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Ser 
            


<210>  14
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of F6A

<400>  14

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr 
1               5                   10                  


<210>  15
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of 6FA
<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of 6FA

<400>  16
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat atctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aagcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtatcc ttcttcgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  17
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of 6FA

<400>  17

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  18
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of 6FA

<400>  18
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  19
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of 6FA

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  20
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of 6FA

<400>  20
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat atctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aagcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtatcc ttcttcgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  21
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of 6FA

<400>  21

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  22
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of 6FA

<400>  22
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  23
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of 6FA

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  24
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of 6FA

<400>  24
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat atctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aagcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtatcc ttcttcgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  25
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of 6FA

<400>  25

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  26
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of 6FA

<400>  26
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat atctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aagcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtatcc ttcttcgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  27
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of H2C

<400>  27

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  28
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of H2C

<400>  28

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of H2C

<400>  29

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  30
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of H2C

<400>  30

Lys Tyr Ala Met Asn 
1               5   


<210>  31
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of H2C

<400>  31

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  32
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of H2C

<400>  32

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  33
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of H2C

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of H2C

<400>  34
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  35
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of H2C

<400>  35

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  36
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of H2C

<400>  36
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  37
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of H2C

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of H2C

<400>  38
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  39
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of H2C

<400>  39

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  40
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of H2C

<400>  40
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  41
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of H2C

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  42
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of H2C

<400>  42
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  43
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of H2C

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  44
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of H2C

<400>  44
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  45
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of H1E

<400>  45

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  46
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of H1E

<400>  46

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of H1E

<400>  47

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  48
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of H1E

<400>  48

Ser Tyr Ala Met Asn 
1               5   


<210>  49
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of H1E

<400>  49

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  50
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of H1E

<400>  50

His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp Ala Tyr 
1               5                   10                  


<210>  51
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of H1E

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  374
<212>  DNA
<213>  artificial

<220>
<223>  VH of H1E

<400>  52
gaggtgcagc tggtcgagtc tggaggagga ttggagcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat tcgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacctatcc ttctgggctt actggggcca agggactctg      360

gtcaccgtct cctc                                                        374


<210>  53
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of H1E

<400>  53

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  54
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of H1E

<400>  54
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  55
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of H1E

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  56
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of H1E

<400>  56
gaggtgcagc tgctcgagtc tggaggagga ttggagcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat tcgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacctatcc ttctgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  57
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of H1E

<400>  57

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  58
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of H1E

<400>  58
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  59
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of H1E

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  60
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of H1E

<400>  60
gaggtgcagc tggtcgagtc tggaggagga ttggagcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat tcgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacctatcc ttctgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  61
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of H1E

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  62
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of H1E

<400>  62
gaggtgcagc tgctcgagtc tggaggagga ttggagcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat tcgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacctatcc ttctgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  63
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of G4H

<400>  63

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  64
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of G4H

<400>  64

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of G4H

<400>  65

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  66
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of G4H

<400>  66

Arg Tyr Ala Met Asn 
1               5   


<210>  67
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of G4H

<400>  67

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  68
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of G4H


<400>  68

His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe Ala Tyr 
1               5                   10                  


<210>  69
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of G4H

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  70
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of G4H

<400>  70
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat cgctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tacttcgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  71
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of G4H

<400>  71

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  72
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of G4H

<400>  72
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  73
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of G4H

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  74
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of G4H

<400>  74
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat cgctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tacttcgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  75
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of G4H

<400>  75

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  76
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of G4H

<400>  76
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  77
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of G4H

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  78
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of G4H

<400>  78
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat cgctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tacttcgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  79
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of G4H

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  80
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of G4H

<400>  80
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat cgctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agggaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tacttcgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  81
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of A2J

<400>  81

Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  82
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of A2J

<400>  82

Ala Thr Asp Met Arg Pro Ser 
1               5           


<210>  83
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of A2J

<400>  83

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  84
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of A2J

<400>  84

Val Tyr Ala Met Asn 
1               5   


<210>  85
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of A2J

<400>  85

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Lys 
            


<210>  86
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of A2J

<400>  86

His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp Ala Tyr 
1               5                   10                  


<210>  87
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of A2J

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  88
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of A2J

<400>  88
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  89
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of A2J

<400>  89

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  90
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of A2J

<400>  90
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  91
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of A2J

<400>  91

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  92
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of A2J

<400>  92
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  93
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of A2J

<400>  93

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  94
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of A2J

<400>  94
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  95
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of A2J

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  96
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of A2J

<400>  96
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  97
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of A2J

<400>  97

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  98
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of A2J

<400>  98
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacttatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  99
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of E1L

<400>  99

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  100
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of E1L

<400>  100

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  101
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of E1L

<400>  101

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  102
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of E1L

<400>  102

Lys Tyr Ala Met Asn 
1               5   


<210>  103
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of E1L

<400>  103

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Ser 
            


<210>  104
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of E1L

<400>  104

His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr Ala Tyr 
1               5                   10                  


<210>  105
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of E1L

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  106
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of E1L

<400>  106
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa atcgaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacacatcc tactacgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  107
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of E1L

<400>  107

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  108
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of E1L

<400>  108
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  109
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of E1L

<400>  109

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  110
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of E1L

<400>  110
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa atcgaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacacatcc tactacgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  111
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of E1L

<400>  111

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  112
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of E1L

<400>  112
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  113
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of E1L

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  114
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of E1L

<400>  114
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa atcgaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacacatcc tactacgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  115
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of E1L

<400>  115

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  116
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of E1L

<400>  116
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa atcgaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacacatcc tactacgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  117
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of E2M

<400>  117

Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  118
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of E2M

<400>  118

Ala Thr Asp Met Arg Pro Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of E2M

<400>  119

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  120
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of E2M

<400>  120

Gly Tyr Ala Met Asn 
1               5   


<210>  121
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of E2M

<400>  121

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Glu 
            


<210>  122
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of E2M

<400>  122

His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  123
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of E2M

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  124
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of E2M

<400>  124
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat ggctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

cataggaact tcggtaatag ctacttatcc tggttcgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  125
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of E2M

<400>  125

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  126
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of E2M


<400>  126
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  127
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of E2M

<400>  127

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  128
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of E2M

<400>  128
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat ggctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

cataggaact tcggtaatag ctacttatcc tggttcgctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  129
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of E2M

<400>  129

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  130
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of E2M

<400>  130
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  131
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of E2M

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  132
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of E2M

<400>  132
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat ggctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

cataggaact tcggtaatag ctacttatcc tggttcgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  133
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of E2M

<400>  133

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
            180                 185                 190         


Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  134
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of E2M

<400>  134
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat ggctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

cataggaact tcggtaatag ctacttatcc tggttcgctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtcgct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgccactg acatgaggcc ctctggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  135
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of F7O

<400>  135

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  136
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of F7O

<400>  136

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  137
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of F7O

<400>  137

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  138
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of F7O

<400>  138

Val Tyr Ala Met Asn 
1               5   


<210>  139
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of F7O

<400>  139

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Lys 
            


<210>  140
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of F7O

<400>  140

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp Ala Tyr 
1               5                   10                  


<210>  141
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of F7O

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  142
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of F7O

<400>  142
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  143
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of F7O

<400>  143

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  144
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of F7O

<400>  144
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  145
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of F7O

<400>  145

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  146
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of F7O

<400>  146
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  147
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of F7O

<400>  147

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  148
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of F7O

<400>  148
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  149
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of F7O

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  150
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of F7O

<400>  150
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  151
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of F7O

<400>  151

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  152
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of F7O

<400>  152
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat gtgtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aaagaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggctact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gctctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  153
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of F12Q

<400>  153

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  154
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of F12Q

<400>  154

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  155
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of F12Q

<400>  155

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  156
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of F12Q

<400>  156

Ser Tyr Ala Met Asn 
1               5   


<210>  157
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of F12Q

<400>  157

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  158
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of F12Q

<400>  158

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr 
1               5                   10                  


<210>  159
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of F12Q

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  160
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of F12Q

<400>  160
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat agctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aggcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtttcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  161
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of F12Q

<400>  161

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  162
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of F12Q

<400>  162
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  163
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of F12Q

<400>  163

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  164
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of F12Q

<400>  164
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat agctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aggcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtttcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  165
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of F12Q

<400>  165

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  166
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of F12Q

<400>  166
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  167
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of F12Q

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  168
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of F12Q

<400>  168
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat agctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aggcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtttcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  169
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of F12Q

<400>  169

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  170
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of F12Q

<400>  170
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat agctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa aggcaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacgtttcc tggtgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  171
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L1 of I2C

<400>  171

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  172
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L2 of I2C

<400>  172

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  173
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR-L3 of I2C

<400>  173

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  174
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H1 of I2C

<400>  174

Lys Tyr Ala Met Asn 
1               5   


<210>  175
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H2 of I2C

<400>  175

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  176
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CDR-H3 of I2C

<400>  176

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  177
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH of I2C

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  178
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH of I2C

<400>  178
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  179
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL of I2C

<400>  179

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  180
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL of I2C

<400>  180
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  181
<211>  125
<212>  PRT
<213>  artificial

<220>
<223>  VH-P of I2C

<400>  181

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  182
<211>  375
<212>  DNA
<213>  artificial

<220>
<223>  VH-P of I2C

<400>  182
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210>  183
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  VL-P of I2C

<400>  183

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  184
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  VL-P of I2C

<400>  184
gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  185
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL of I2C

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  186
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL of I2C

<400>  186
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  187
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  VH-VL-P of I2C

<400>  187

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
    130                 135                 140                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
145                 150                 155                 160 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                165                 170                 175     


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
            180                 185                 190         


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
        195                 200                 205             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
    210                 215                 220                 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  188
<211>  747
<212>  DNA
<213>  artificial

<220>
<223>  VH-VL-P of I2C

<400>  188
gaggtgcagc tgctcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctcaggtgg tggtggttct ggcggcggcg gctccggtgg tggtggttct      420

gagctcgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc      480

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      540

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      600

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      660

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      720

ggtggaggaa ccaaactgac tgtccta                                          747


<210>  189
<211>  267
<212>  PRT
<213>  artificial

<220>
<223>  1-27 CD3 epsilon-Fc

<400>  189

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Ser Gly Glu Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys His His His His His His 
            260                 265         


<210>  190
<211>  858
<212>  DNA
<213>  artificial

<220>
<223>  1-27 CD3 epsilon-Fc

<400>  190
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccaa       60

gatggtaatg aagaaatggg tggtattaca cagacaccat ataaagtctc catctctgga      120

accacagtaa tattgacatc cggagagccc aaatcttgtg acaaaactca cacatgccca      180

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      240

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      300

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      360

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      420

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      480

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      540

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc      600

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      660

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat      720

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      780

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc cccgggtaaa      840

catcatcacc atcatcat                                                    858


<210>  191
<211>  333
<212>  PRT
<213>  artificial

<220>
<223>  human 1-27 CD3 epsilon-Fc-EpCAM

<400>  191

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Thr Ala Ser Phe Ala Ala Ala Gln Lys Glu Cys Val Cys 
        35                  40                  45              


Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe Leu Asn Asp Asn Gly Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ile Gly Ala Gln Asn Thr Val Leu Cys Ser Lys 
65                  70                  75                  80  


Leu Ala Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys 
                85                  90                  95      


Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly 
            100                 105                 110         


Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln 
        115                 120                 125             


Cys Asn Gly Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg 
    130                 135                 140                 


Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr 
145                 150                 155                 160 


Tyr Trp Ile Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr 
                165                 170                 175     


Asp Val Gln Ser Leu Arg Thr Ala Leu Glu Glu Ala Ile Lys Thr Arg 
            180                 185                 190         


Tyr Gln Leu Asp Pro Lys Phe Ile Thr Asn Ile Leu Tyr Glu Asp Asn 
        195                 200                 205             


Val Ile Thr Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn 
    210                 215                 220                 


Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys 
225                 230                 235                 240 


Gly Glu Ser Leu Phe His Ser Lys Lys Met Asp Leu Arg Val Asn Gly 
                245                 250                 255     


Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp 
            260                 265                 270         


Glu Lys Ala Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile 
        275                 280                 285             


Ala Val Ile Val Val Val Val Ile Ala Ile Val Ala Gly Ile Val Val 
    290                 295                 300                 


Leu Val Ile Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu 
305                 310                 315                 320 


Ile Lys Glu Met Gly Glu Met His Arg Glu Leu Asn Ala 
                325                 330             


<210>  192
<211>  1056
<212>  DNA
<213>  artificial

<220>
<223>  human 1-27 CD3 epsilon-EpCAM

<400>  192
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccaa       60

gatggtaatg aagaaatggg tggtattaca cagacaccat ataaagtctc catctctgga      120

accacagtaa tattgacaga ttacaaggac gacgatgaca agactgcgag ttttgccgca      180

gctcagaaag aatgtgtctg tgaaaactac aagctggccg taaactgctt tttgaatgac      240

aatggtcaat gccagtgtac ttcgattggt gcacaaaata ctgtcctttg ctcaaagctg      300

gctgccaaat gtttggtgat gaaggcagaa atgaacggct caaaacttgg gagaagagcg      360

aaacctgaag gggctctcca gaacaatgat ggcctttacg atcctgactg cgatgagagc      420

gggctcttta aggccaagca gtgcaacggc acctccacgt gctggtgtgt gaacactgct      480

ggggtcagaa gaactgacaa ggacactgaa ataacctgct ctgagcgagt gagaacctac      540

tggatcatca ttgaattaaa acacaaagca agagaaaaac cttatgatgt tcaaagtttg      600

cggactgcac ttgaggaggc gatcaaaacg cgttatcaac tggatccaaa atttatcaca      660

aatattttgt atgaggataa tgttatcact attgatctgg ttcaaaattc ttctcagaaa      720

actcagaatg atgtggacat agctgatgtg gcttattatt ttgaaaaaga tgttaaaggt      780

gaatccttgt ttcattctaa gaaaatggac ctgagagtaa atggggaaca actggatctg      840

gatcctggtc aaactttaat ttattatgtc gatgaaaaag cacctgaatt ctcaatgcag      900

ggtctaaaag ctggtgttat tgctgttatt gtggttgtgg tgatagcaat tgttgctgga      960

attgttgtgc tggttatttc cagaaagaag agaatggcaa agtatgagaa ggctgagata     1020

aaggagatgg gtgagatgca tagggaactc aatgca                               1056


<210>  193
<211>  333
<212>  PRT
<213>  artificial

<220>
<223>  marmoset 1-27 CD3 epsilon-EpCAM

<400>  193

Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Thr Ala Ser Phe Ala Ala Ala Gln Lys Glu Cys Val Cys 
        35                  40                  45              


Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe Leu Asn Asp Asn Gly Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ile Gly Ala Gln Asn Thr Val Leu Cys Ser Lys 
65                  70                  75                  80  


Leu Ala Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys 
                85                  90                  95      


Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly 
            100                 105                 110         


Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln 
        115                 120                 125             


Cys Asn Gly Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg 
    130                 135                 140                 


Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr 
145                 150                 155                 160 


Tyr Trp Ile Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr 
                165                 170                 175     


Asp Val Gln Ser Leu Arg Thr Ala Leu Glu Glu Ala Ile Lys Thr Arg 
            180                 185                 190         


Tyr Gln Leu Asp Pro Lys Phe Ile Thr Asn Ile Leu Tyr Glu Asp Asn 
        195                 200                 205             


Val Ile Thr Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn 
    210                 215                 220                 


Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys 
225                 230                 235                 240 


Gly Glu Ser Leu Phe His Ser Lys Lys Met Asp Leu Arg Val Asn Gly 
                245                 250                 255     


Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp 
            260                 265                 270         


Glu Lys Ala Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile 
        275                 280                 285             


Ala Val Ile Val Val Val Val Ile Ala Ile Val Ala Gly Ile Val Val 
    290                 295                 300                 


Leu Val Ile Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu 
305                 310                 315                 320 


Ile Lys Glu Met Gly Glu Met His Arg Glu Leu Asn Ala 
                325                 330             


<210>  194
<211>  1056
<212>  DNA
<213>  artificial

<220>
<223>  marmoset 1-27 CD3 epsilon-EpCAM

<400>  194
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccag       60

gacggtaatg aagaaatggg tgatactaca cagaacccat ataaagtttc catctcagga      120

accacagtaa cactgacaga ttacaaggac gacgatgaca agactgcgag ttttgccgca      180

gctcagaaag aatgtgtctg tgaaaactac aagctggccg taaactgctt tttgaatgac      240

aatggtcaat gccagtgtac ttcgattggt gcacaaaata ctgtcctttg ctcaaagctg      300

gctgccaaat gtttggtgat gaaggcagaa atgaacggct caaaacttgg gagaagagcg      360

aaacctgaag gggctctcca gaacaatgat ggcctttacg atcctgactg cgatgagagc      420

gggctcttta aggccaagca gtgcaacggc acctccacgt gctggtgtgt gaacactgct      480

ggggtcagaa gaactgacaa ggacactgaa ataacctgct ctgagcgagt gagaacctac      540

tggatcatca ttgaattaaa acacaaagca agagaaaaac cttatgatgt tcaaagtttg      600

cggactgcac ttgaggaggc gatcaaaacg cgttatcaac tggatccaaa atttatcaca      660

aatattttgt atgaggataa tgttatcact attgatctgg ttcaaaattc ttctcagaaa      720

actcagaatg atgtggacat agctgatgtg gcttattatt ttgaaaaaga tgttaaaggt      780

gaatccttgt ttcattctaa gaaaatggac ctgagagtaa atggggaaca actggatctg      840

gatcctggtc aaactttaat ttattatgtc gatgaaaaag cacctgaatt ctcaatgcag      900

ggtctaaaag ctggtgttat tgctgttatt gtggttgtgg tgatagcaat tgttgctgga      960

attgttgtgc tggttatttc cagaaagaag agaatggcaa agtatgagaa ggctgagata     1020

aaggagatgg gtgagatgca tagggaactc aatgca                               1056


<210>  195
<211>  333
<212>  PRT
<213>  artificial

<220>
<223>  tamarin 1-27 CD3 epsilon-EpCAM

<400>  195

Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Thr Ala Ser Phe Ala Ala Ala Gln Lys Glu Cys Val Cys 
        35                  40                  45              


Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe Leu Asn Asp Asn Gly Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ile Gly Ala Gln Asn Thr Val Leu Cys Ser Lys 
65                  70                  75                  80  


Leu Ala Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys 
                85                  90                  95      


Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly 
            100                 105                 110         


Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln 
        115                 120                 125             


Cys Asn Gly Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg 
    130                 135                 140                 


Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr 
145                 150                 155                 160 


Tyr Trp Ile Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr 
                165                 170                 175     


Asp Val Gln Ser Leu Arg Thr Ala Leu Glu Glu Ala Ile Lys Thr Arg 
            180                 185                 190         


Tyr Gln Leu Asp Pro Lys Phe Ile Thr Asn Ile Leu Tyr Glu Asp Asn 
        195                 200                 205             


Val Ile Thr Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn 
    210                 215                 220                 


Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys 
225                 230                 235                 240 


Gly Glu Ser Leu Phe His Ser Lys Lys Met Asp Leu Arg Val Asn Gly 
                245                 250                 255     


Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp 
            260                 265                 270         


Glu Lys Ala Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile 
        275                 280                 285             


Ala Val Ile Val Val Val Val Ile Ala Ile Val Ala Gly Ile Val Val 
    290                 295                 300                 


Leu Val Ile Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu 
305                 310                 315                 320 


Ile Lys Glu Met Gly Glu Met His Arg Glu Leu Asn Ala 
                325                 330             


<210>  196
<211>  1056
<212>  DNA
<213>  artificial

<220>
<223>  tamarin 1-27 CD3 epsilon-EpCAM

<400>  196
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccag       60

gacggtaatg aagaaatggg tgatactaca cagaacccat ataaagtttc catctcagga      120

accacagtaa cactgacaga ttacaaggac gacgatgaca agactgcgag ttttgccgca      180

gctcagaaag aatgtgtctg tgaaaactac aagctggccg taaactgctt tttgaatgac      240

aatggtcaat gccagtgtac ttcgattggt gcacaaaata ctgtcctttg ctcaaagctg      300

gctgccaaat gtttggtgat gaaggcagaa atgaacggct caaaacttgg gagaagagcg      360

aaacctgaag gggctctcca gaacaatgat ggcctttacg atcctgactg cgatgagagc      420

gggctcttta aggccaagca gtgcaacggc acctccacgt gctggtgtgt gaacactgct      480

ggggtcagaa gaactgacaa ggacactgaa ataacctgct ctgagcgagt gagaacctac      540

tggatcatca ttgaattaaa acacaaagca agagaaaaac cttatgatgt tcaaagtttg      600

cggactgcac ttgaggaggc gatcaaaacg cgttatcaac tggatccaaa atttatcaca      660

aatattttgt atgaggataa tgttatcact attgatctgg ttcaaaattc ttctcagaaa      720

actcagaatg atgtggacat agctgatgtg gcttattatt ttgaaaaaga tgttaaaggt      780

gaatccttgt ttcattctaa gaaaatggac ctgagagtaa atggggaaca actggatctg      840

gatcctggtc aaactttaat ttattatgtc gatgaaaaag cacctgaatt ctcaatgcag      900

ggtctaaaag ctggtgttat tgctgttatt gtggttgtgg tgatagcaat tgttgctgga      960

attgttgtgc tggttatttc cagaaagaag agaatggcaa agtatgagaa ggctgagata     1020

aaggagatgg gtgagatgca tagggaactc aatgca                               1056


<210>  197
<211>  369
<212>  PRT
<213>  artificial

<220>
<223>  squirrel monkey 1-27 CD3 epsilon-EpCAM

<400>  197

Gln Asp Gly Asn Glu Glu Ile Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Thr Ala Ser Phe Ala Ala Ala Gln Lys Glu Cys Val Cys 
        35                  40                  45              


Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe Leu Asn Asp Asn Gly Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ile Gly Ala Gln Asn Thr Val Leu Cys Ser Lys 
65                  70                  75                  80  


Leu Ala Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys 
                85                  90                  95      


Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly 
            100                 105                 110         


Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln 
        115                 120                 125             


Cys Asn Gly Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg 
    130                 135                 140                 


Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr 
145                 150                 155                 160 


Tyr Trp Ile Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr 
                165                 170                 175     


Asp Val Gln Ser Leu Arg Thr Ala Leu Glu Glu Ala Ile Lys Thr Arg 
            180                 185                 190         


Tyr Gln Leu Asp Pro Lys Phe Ile Thr Asn Ile Leu Tyr Glu Asp Asn 
        195                 200                 205             


Val Ile Thr Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn 
    210                 215                 220                 


Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys 
225                 230                 235                 240 


Gly Glu Ser Leu Phe His Ser Lys Lys Met Asp Leu Arg Val Asn Gly 
                245                 250                 255     


Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp 
            260                 265                 270         


Glu Lys Ala Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile 
        275                 280                 285             


Ala Val Ile Val Val Val Val Ile Ala Ile Val Ala Gly Ile Val Val 
    290                 295                 300                 


Leu Val Ile Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu 
305                 310                 315                 320 


Ile Lys Glu Met Gly Glu Met His Arg Glu Leu Asn Ala Ala Ala Gly 
                325                 330                 335     


Gly Ala Gly Ala Thr Gly Gly Gly Thr Gly Ala Gly Ala Thr Gly Cys 
            340                 345                 350         


Ala Thr Ala Gly Gly Gly Ala Ala Cys Thr Cys Ala Ala Thr Gly Cys 
        355                 360                 365             


Ala 
    


<210>  198
<211>  1056
<212>  DNA
<213>  artificial

<220>
<223>  squirrel monkey 1-27 CD3 epsilon-EpCAM

<400>  198
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccag       60

gacggtaatg aagagattgg tgatactacc cagaacccat ataaagtttc catctcagga      120

accacagtaa cactgacaga ttacaaggac gacgatgaca agactgcgag ttttgccgca      180

gctcagaaag aatgtgtctg tgaaaactac aagctggccg taaactgctt tttgaatgac      240

aatggtcaat gccagtgtac ttcgattggt gcacaaaata ctgtcctttg ctcaaagctg      300

gctgccaaat gtttggtgat gaaggcagaa atgaacggct caaaacttgg gagaagagcg      360

aaacctgaag gggctctcca gaacaatgat ggcctttacg atcctgactg cgatgagagc      420

gggctcttta aggccaagca gtgcaacggc acctccacgt gctggtgtgt gaacactgct      480

ggggtcagaa gaactgacaa ggacactgaa ataacctgct ctgagcgagt gagaacctac      540

tggatcatca ttgaattaaa acacaaagca agagaaaaac cttatgatgt tcaaagtttg      600

cggactgcac ttgaggaggc gatcaaaacg cgttatcaac tggatccaaa atttatcaca      660

aatattttgt atgaggataa tgttatcact attgatctgg ttcaaaattc ttctcagaaa      720

actcagaatg atgtggacat agctgatgtg gcttattatt ttgaaaaaga tgttaaaggt      780

gaatccttgt ttcattctaa gaaaatggac ctgagagtaa atggggaaca actggatctg      840

gatcctggtc aaactttaat ttattatgtc gatgaaaaag cacctgaatt ctcaatgcag      900

ggtctaaaag ctggtgttat tgctgttatt gtggttgtgg tgatagcaat tgttgctgga      960

attgttgtgc tggttatttc cagaaagaag agaatggcaa agtatgagaa ggctgagata     1020

aaggagatgg gtgagatgca tagggaactc aatgca                               1056


<210>  199
<211>  333
<212>  PRT
<213>  artificial

<220>
<223>  swine 1-27 CD3 epsilon-EpCAM

<400>  199

Gln Glu Asp Ile Glu Arg Pro Asp Glu Asp Thr Gln Lys Thr Phe Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Asp Lys Val Glu Leu Thr Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Thr Ala Ser Phe Ala Ala Ala Gln Lys Glu Cys Val Cys 
        35                  40                  45              


Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe Leu Asn Asp Asn Gly Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ile Gly Ala Gln Asn Thr Val Leu Cys Ser Lys 
65                  70                  75                  80  


Leu Ala Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys 
                85                  90                  95      


Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly 
            100                 105                 110         


Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln 
        115                 120                 125             


Cys Asn Gly Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg 
    130                 135                 140                 


Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr 
145                 150                 155                 160 


Tyr Trp Ile Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr 
                165                 170                 175     


Asp Val Gln Ser Leu Arg Thr Ala Leu Glu Glu Ala Ile Lys Thr Arg 
            180                 185                 190         


Tyr Gln Leu Asp Pro Lys Phe Ile Thr Asn Ile Leu Tyr Glu Asp Asn 
        195                 200                 205             


Val Ile Thr Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn 
    210                 215                 220                 


Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys 
225                 230                 235                 240 


Gly Glu Ser Leu Phe His Ser Lys Lys Met Asp Leu Arg Val Asn Gly 
                245                 250                 255     


Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp 
            260                 265                 270         


Glu Lys Ala Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile 
        275                 280                 285             


Ala Val Ile Val Val Val Val Ile Ala Ile Val Ala Gly Ile Val Val 
    290                 295                 300                 


Leu Val Ile Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu 
305                 310                 315                 320 


Ile Lys Glu Met Gly Glu Met His Arg Glu Leu Asn Ala 
                325                 330             


<210>  200
<211>  1056
<212>  DNA
<213>  artificial

<220>
<223>  swine 1-27 CD3 epsilon-EpCAM

<400>  200
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccaa       60

gaagacattg aaagaccaga tgaagataca cagaaaacat ttaaagtctc catctctgga      120

gacaaagtag agctgacaga ttacaaggac gacgatgaca agactgcgag ttttgccgca      180

gctcagaaag aatgtgtctg tgaaaactac aagctggccg taaactgctt tttgaatgac      240

aatggtcaat gccagtgtac ttcgattggt gcacaaaata ctgtcctttg ctcaaagctg      300

gctgccaaat gtttggtgat gaaggcagaa atgaacggct caaaacttgg gagaagagcg      360

aaacctgaag gggctctcca gaacaatgat ggcctttacg atcctgactg cgatgagagc      420

gggctcttta aggccaagca gtgcaacggc acctccacgt gctggtgtgt gaacactgct      480

ggggtcagaa gaactgacaa ggacactgaa ataacctgct ctgagcgagt gagaacctac      540

tggatcatca ttgaattaaa acacaaagca agagaaaaac cttatgatgt tcaaagtttg      600

cggactgcac ttgaggaggc gatcaaaacg cgttatcaac tggatccaaa atttatcaca      660

aatattttgt atgaggataa tgttatcact attgatctgg ttcaaaattc ttctcagaaa      720

actcagaatg atgtggacat agctgatgtg gcttattatt ttgaaaaaga tgttaaaggt      780

gaatccttgt ttcattctaa gaaaatggac ctgagagtaa atggggaaca actggatctg      840

gatcctggtc aaactttaat ttattatgtc gatgaaaaag cacctgaatt ctcaatgcag      900

ggtctaaaag ctggtgttat tgctgttatt gtggttgtgg tgatagcaat tgttgctgga      960

attgttgtgc tggttatttc cagaaagaag agaatggcaa agtatgagaa ggctgagata     1020

aaggagatgg gtgagatgca tagggaactc aatgca                               1056


<210>  201
<211>  186
<212>  PRT
<213>  human

<400>  201

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
            100                 105                 110         


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
        115                 120                 125             


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
    130                 135                 140                 


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
145                 150                 155                 160 


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
                165                 170                 175     


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185     


<210>  202
<211>  621
<212>  DNA
<213>  human

<400>  202
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcacg cgtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacccaga ctatgagccc atccggaaag gccagcggga cctgtattct      600

ggcctgaatc agagacgcat c                                                621


<210>  203
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  immunoglobulin leader peptide

<400>  203

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  204
<211>  57
<212>  DNA
<213>  artificial

<220>
<223>  immunoglobulin leader peptide

<400>  204
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcc          57


<210>  205
<211>  324
<212>  PRT
<213>  murine

<400>  205

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  206
<211>  972
<212>  DNA
<213>  murine

<400>  206
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac       60

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      120

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac      180

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc      240

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      300

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      360

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      420

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      480

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc      540

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      600

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg      660

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc      720

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg      780

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct      840

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc      900

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac      960

tctcctggta aa                                                          972


<210>  207
<211>  106
<212>  PRT
<213>  human

<400>  207

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  208
<211>  318
<212>  DNA
<213>  human

<400>  208
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  209
<211>  843
<212>  DNA
<213>  artificial

<220>
<223>  1-27 CD3-Fc + leader

<400>  209
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt acactcccaa       60

gatggtaatg aagaaatggg tggtattaca cagacaccat ataaagtctc catctctgga      120

accacagtaa tattgacatc cggagagccc aaatcttgtg acaaaactca cacatgccca      180

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      240

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      300

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      360

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      420

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      480

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      540

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc      600

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      660

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat      720

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      780

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc cccgggtaaa      840

tag                                                                    843


<210>  210
<211>  280
<212>  PRT
<213>  artificial

<220>
<223>  1-27 CD3-Fc + leader

<400>  210

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr 
            20                  25                  30          


Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Ser Gly 
        35                  40                  45              


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    50                  55                  60                  


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
65                  70                  75                  80  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                85                  90                  95      


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            100                 105                 110         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        115                 120                 125             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    130                 135                 140                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
145                 150                 155                 160 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                165                 170                 175     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            180                 185                 190         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        195                 200                 205             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    210                 215                 220                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
225                 230                 235                 240 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                245                 250                 255     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            260                 265                 270         


Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280 


<210>  211
<211>  8
<212>  PRT
<213>  human

<400>  211

Gln Asp Gly Asn Glu Glu Met Gly 
1               5               


<210>  212
<211>  8
<212>  PRT
<213>  Saimiri sciureus

<400>  212

Gln Asp Gly Asn Glu Glu Ile Gly 
1               5               


<210>  213
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  forward primer

<400>  213
cactgtggcc caggttcgag g                                                 21


<210>  214
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer

<400>  214
gacataccac acaaattcaa tacgg                                             25


<210>  215
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  forward primer

<400>  215
gctctgctcg cgccgagatg tgg                                               23


<210>  216
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer

<400>  216
acgctggaca ccacctccag g                                                 21


<210>  217
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  forward primer

<400>  217
ggttctactg agtgggcaga gg                                                22


<210>  218
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer

<400>  218
acttgttgtg gctgcttgga gc                                                22


<210>  219
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  forward primer

<400>  219
gggtgaagtc ctatccagat gg                                                22


<210>  220
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer

<400>  220
gtgctctgcc tgaagcaatt cc                                                22


<210>  221
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  forward primer

<400>  221
ctcggcttcc tcttcgggtg g                                                 21


<210>  222
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer

<400>  222
gcatattcat ttgctgggta acctgg                                            26


<210>  223
<211>  2253
<212>  DNA
<213>  artificial

<220>
<223>  macaque PSMA (Cynomolgus)

<400>  223
atgtggaatc tcctgcacga aaccgactcg gctgtggcca ccgcgcgccg cccgcgctgg       60

ctgtgcgctg gggcactggt gctggcgggt ggcttctttc tcctcggctt cctcttcgga      120

tggtttataa aatcctccag tgaagctact aacattactc caaagcataa tatgaaagca      180

tttttggatg aactgaaagc tgagaacatc aagaagttct tacataattt tacacagata      240

ccacatttag caggaacaga acaaaacttt caacttgcaa agcaaattca atcccagtgg      300

aaagaatttg gcctggattc tgttgagcta actcattatg atgtcctgtt gtcctaccca      360

aataagactc atcccaacta catctcaata attaatgaag atggaaatga gattttcaac      420

acatcattat ttgaaccacc tcctgcagga tatgaaaatg tttcggatat tgtaccacct      480

ttcagtgctt tctctcctca aggaatgcca gagggcgatc tagtgtatgt taactatgca      540

cgaactgaag acttctttaa attggaacgg gacatgaaaa tcaattgctc tgggaaaatt      600

gtaattgcca gatatgggaa agttttcaga ggaaataagg ttaaaaatgc ccagctggca      660

ggggccacag gagtcattct ctactcagac cctgctgact actttgctcc tggggtaaag      720

tcttatccag atggttggaa tcttcctgga ggtggtgtcc agcgtggaaa tatcctaaat      780

ctgaatggtg caggagaccc tctcacacca ggttacccag caaatgaata tgcttatagg      840

cgtggaatgg cagaggctgt tggtcttcca agtattcccg ttcatccaat tgggtactat      900

gatgcacaga agctcctaga aaaaatgggt ggctcagcat caccagatag cagctggaga      960

ggaagtctca aagtgcccta caatgttgga cctggcttta ctggaaactt ttctacacaa     1020

aaagtcaaga tgcacatcca ctctaccagt gaagtgacaa gaatttacaa tgtgataggt     1080

actctcagag gagcagtgga accagacaga tacgtcattc tgggaggtca ccgggactca     1140

tgggtgtttg gtggtattga ccctcagagt ggagcagctg ttgttcatga aattgtgagg     1200

agctttggaa cgctgaaaaa ggaagggtgg agacctagaa gaacaatttt gtttgcaagc     1260

tgggatgcag aagaatttgg tcttcttggt tctactgaat gggcagagga gaattcaaga     1320

ctccttcaag agcgtggcgt ggcttatatt aatgctgatt cgtctataga gggaaactac     1380

actctgagag ttgattgtac accactgatg tacagcttgg tatacaacct aacaaaagag     1440

ctggaaagcc ctgatgaagg ctttgaaggc aaatctcttt atgaaagttg gactaaaaaa     1500

agtccttccc ccgagttcag tggcatgccc aggataagca aattgggatc tggaaatgat     1560

tttgaggtgt tcttccaacg acttggaatt gcctcaggca gagcacggta tactaaaaat     1620

tgggaaacaa acaaattcag cagctatcca ctgtatcaca gtgtctatga gacatatgag     1680

ttggtggaaa agttttatga tccaatgttt aaatatcacc tcactgtggc ccaggttcga     1740

ggagggatgg tgtttgaact agccaattcc gtagtgctcc cttttgattg tcgagattat     1800

gctgtagttt taagaaagta tgctgacaaa atctacaata tttctatgaa acatccacag     1860

gaaatgaaga catacagtgt atcatttgat tcactttttt ctgcagtaaa gaattttaca     1920

gaaattgctt ccaagttcag cgagagactc cgggactttg acaaaagcaa cccaatatta     1980

ttaagaatga tgaatgatca actcatgttt ctggaaagag catttattga tccattaggg     2040

ttaccagaca gaccttttta taggcatgtc atctatgctc caagcagcca caacaagtat     2100

gcaggggagt cattcccagg aatttatgat gctctgtttg atatcgaaag caaagtggac     2160

ccttcccagg cctggggaga agtgaagaga cagatttctg ttgcaacctt cacagtgcaa     2220

gcagctgcag agactttgag tgaagtggcc taa                                  2253


<210>  224
<211>  750
<212>  PRT
<213>  artificial

<220>
<223>  macaque PSMA (Cynomolgus)

<400>  224

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Ser Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu His Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Thr His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Ala Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Thr Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Met Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Ser Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Ser Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Glu Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Ser Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Val Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Arg Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Leu Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Gln Ala Trp Gly Glu Val Lys Arg Gln Ile Ser Val Ala Thr 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  225
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-VH

<400>  225

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  226
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-HCDR1

<400>  226

Tyr Phe Asp Ile Asn 
1               5   


<210>  227
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-HCDR2

<400>  227

Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  228
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-HCDR3

<400>  228

Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser 
1               5                   10      


<210>  229
<211>  360
<212>  DNA
<213>  artificial

<220>
<223>  PM52C3-VH

<400>  229
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtcac cgtctcctca      360


<210>  230
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-VL

<400>  230

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  231
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-LCDR1

<400>  231

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  232
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-LCDR2

<400>  232

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  233
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-LCDR3

<400>  233

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  234
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  PM52C3-VL

<400>  234
gacgtcgtga tgactcagtc tccactctcc ctgcccgtca cccttggaga gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtaacg gaaacaccta cttgcattgg      120

tatcaacaga agccaggcca atctccaaga ctcctaattt ataaggtttc taaccggttc      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tatttctgct ctcaaagtac acatgttccg      300

tacacgtttg gccaggggac caagctggag atcaaa                                336


<210>  235
<211>  247
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-VH-VL

<400>  235

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  236
<211>  741
<212>  DNA
<213>  artificial

<220>
<223>  PM52C3-VH-VL

<400>  236
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgctctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa a                                                741


<210>  237
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  PM52C3-VH-VL x I2C VH-VL

<400>  237

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         


Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
385                 390                 395                 400 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                405                 410                 415     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        435                 440                 445             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    450                 455                 460                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Thr Val Leu 
            500         


<210>  238
<211>  1506
<212>  DNA
<213>  artificial

<220>
<223>  PM52C3-VH-VL x I2C VH-VL

<400>  238
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgctctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa atccggaggt ggtggatccg aggtgcagct ggtcgagtct      780

ggaggaggat tggtgcagcc tggagggtca ttgaaactct catgtgcagc ctctggattc      840

accttcaata agtacgccat gaactgggtc cgccaggctc caggaaaggg tttggaatgg      900

gttgctcgca taagaagtaa atataataat tatgcaacat attatgccga ttcagtgaaa      960

gacaggttca ccatctccag agatgattca aaaaacactg cctatctaca aatgaacaac     1020

ttgaaaactg aggacactgc cgtgtactac tgtgtgagac atgggaactt cggtaatagc     1080

tacatatcct actgggctta ctggggccaa gggactctgg tcaccgtctc ctcaggtggt     1140

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc agactgttgt gactcaggaa     1200

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1260

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1320

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1380

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1440

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1500

gtccta                                                                1506


<210>  239
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-VH

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  240
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-HCDR1

<400>  240

Tyr Phe Asp Ile Asn 
1               5   


<210>  241
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-HCDR2

<400>  241

Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  242
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-HCDR3

<400>  242

Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser 
1               5                   10      


<210>  243
<211>  360
<212>  DNA
<213>  artificial

<220>
<223>  PM52H3-VH

<400>  243
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtccaaatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtcac cgtctcctca      360


<210>  244
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-VL

<400>  244

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  245
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-LCDR1

<400>  245

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  246
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-LCDR2

<400>  246

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  247
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-LCDR3

<400>  247

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  248
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  PM52H3-VL

<400>  248
gacgtcgtga tgactcagtc tccactctcc ctgcccgtca cccttggaga gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtaacg gaaacaccta cttgcattgg      120

tatcaacaga agccaggcca atctccaaga ctcctaattt ataaggtttc taaccggttc      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tatttctgct ctcaaagtac acatgttccg      300

tacacgtttg gccaggggac caagctggag atcaaa                                336


<210>  249
<211>  247
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-VH-VL

<400>  249

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  250
<211>  741
<212>  DNA
<213>  artificial

<220>
<223>  PM52H3-VH-VL

<400>  250
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtccaaatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgctctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa a                                                741


<210>  251
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  PM52H3-VH-VL x I2C VH-VL

<400>  251

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         


Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
385                 390                 395                 400 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                405                 410                 415     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        435                 440                 445             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    450                 455                 460                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Thr Val Leu 
            500         


<210>  252
<211>  1506
<212>  DNA
<213>  artificial

<220>
<223>  PM52H3-VH-VL x I2C VH-VL

<400>  252
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtccaaatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgctctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa atccggaggt ggtggatccg aggtgcagct ggtcgagtct      780

ggaggaggat tggtgcagcc tggagggtca ttgaaactct catgtgcagc ctctggattc      840

accttcaata agtacgccat gaactgggtc cgccaggctc caggaaaggg tttggaatgg      900

gttgctcgca taagaagtaa atataataat tatgcaacat attatgccga ttcagtgaaa      960

gacaggttca ccatctccag agatgattca aaaaacactg cctatctaca aatgaacaac     1020

ttgaaaactg aggacactgc cgtgtactac tgtgtgagac atgggaactt cggtaatagc     1080

tacatatcct actgggctta ctggggccaa gggactctgg tcaccgtctc ctcaggtggt     1140

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc agactgttgt gactcaggaa     1200

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1260

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1320

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1380

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1440

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1500

gtccta                                                                1506


<210>  253
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-VH

<400>  253

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Val Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  254
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-HCDR1

<400>  254

Tyr Phe Asp Ile Asn 
1               5   


<210>  255
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-HCDR2

<400>  255

Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  256
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-HCDR3

<400>  256

Asp Gly Asn Phe Pro Tyr Tyr Ala Met Val Asn 
1               5                   10      


<210>  257
<211>  360
<212>  DNA
<213>  artificial

<220>
<223>  PM75A10-VH

<400>  257
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgcgat ggtcaactgg ggccagggca ccacggtcac cgtctcctca      360


<210>  258
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-VL

<400>  258

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  259
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-LCDR1

<400>  259

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  260
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-LCDR2

<400>  260

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  261
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-LCDR3

<400>  261

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  262
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  PM75A10-VL

<400>  262
gacgtcgtga tgactcagtc tccactctcc ctgcccgtca cccttggaga gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtaacg gaaacaccta cttgcattgg      120

tatcaacaga agccaggcca atctccaaga ctcctaattt ataaggtttc taaccggttc      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tatttctgtt ctcaaagtac acatgttccg      300

tacacgtttg gccaggggac caagctggag atcaaa                                336


<210>  263
<211>  247
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-VH-VL

<400>  263

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Val Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  264
<211>  741
<212>  DNA
<213>  artificial

<220>
<223>  PM75A10-VH-VL

<400>  264
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgcgat ggtcaactgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgttctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa a                                                741


<210>  265
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  PM75A10-Vh-VL x I2C VH-VL

<400>  265

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Val Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         


Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
385                 390                 395                 400 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                405                 410                 415     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        435                 440                 445             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    450                 455                 460                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Thr Val Leu 
            500         


<210>  266
<211>  1506
<212>  DNA
<213>  artificial

<220>
<223>  PM75A10-Vh-VL x I2C VH-VL

<400>  266
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgcgat ggtcaactgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgttctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa atccggaggt ggtggatccg aggtgcagct ggtcgagtct      780

ggaggaggat tggtgcagcc tggagggtca ttgaaactct catgtgcagc ctctggattc      840

accttcaata agtacgccat gaactgggtc cgccaggctc caggaaaggg tttggaatgg      900

gttgctcgca taagaagtaa atataataat tatgcaacat attatgccga ttcagtgaaa      960

gacaggttca ccatctccag agatgattca aaaaacactg cctatctaca aatgaacaac     1020

ttgaaaactg aggacactgc cgtgtactac tgtgtgagac atgggaactt cggtaatagc     1080

tacatatcct actgggctta ctggggccaa gggactctgg tcaccgtctc ctcaggtggt     1140

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc agactgttgt gactcaggaa     1200

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1260

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1320

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1380

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1440

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1500

gtccta                                                                1506


<210>  267
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-VH

<400>  267

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Thr Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  268
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-HCDR1

<400>  268

Tyr Phe Asp Ile Asn 
1               5   


<210>  269
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-HCDR2

<400>  269

Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  270
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-HCDR3

<400>  270

Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Thr Asn 
1               5                   10      


<210>  271
<211>  360
<212>  DNA
<213>  artificial

<220>
<223>  PM91B6-VH

<400>  271
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccct gaccaactgg ggccagggca ccacggtcac cgtctcctca      360


<210>  272
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-VL

<400>  272

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  273
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-LCDR1

<400>  273

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  274
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-LCDR2

<400>  274

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  275
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-LCDR3

<400>  275

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  276
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  PM91B6-VL

<400>  276
gacgtcgtga tgactcagtc tccactctcc ctgcccgtca cccttggaga gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtaacg gaaacaccta cttgcattgg      120

tatcaacaga agccaggcca atctccaaga ctcctaattt ataaggtttc taaccggttc      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tatttctgtt ctcaaagtac acatgttccg      300

tacacgtttg gccaggggac caagctggag atcaaa                                336


<210>  277
<211>  247
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-VH-VL

<400>  277

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Thr Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  278
<211>  741
<212>  DNA
<213>  artificial

<220>
<223>  PM91B6-VH-VL

<400>  278
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccct gaccaactgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgttctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa a                                                741


<210>  279
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  PM91B6-VH-VL x I2C VH-VL

<400>  279

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Thr Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         


Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
385                 390                 395                 400 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                405                 410                 415     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        435                 440                 445             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    450                 455                 460                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Thr Val Leu 
            500         


<210>  280
<211>  1506
<212>  DNA
<213>  artificial

<220>
<223>  PM91B6-VH-VL x I2C VH-VL

<400>  280
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcagacg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accagagaca cgtcctcatc caccgcctac      240

atggagctgt cccggctgag atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccct gaccaactgg ggccagggca ccacggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgact      420

cagtctccac tctccctgcc cgtcaccctt ggagagccgg cctccatctc ctgcaggtct      480

agtcaaagcc tcgtatacag taacggaaac acctacttgc attggtatca acagaagcca      540

ggccaatctc caagactcct aatttataag gtttctaacc ggttctctgg ggtcccagac      600

agattcagcg gcagtgggtc aggcactgat ttcacactga aaatcagcag ggtggaggct      660

gaggatgttg gggtttattt ctgttctcaa agtacacatg ttccgtacac gtttggccag      720

gggaccaagc tggagatcaa atccggaggt ggtggatccg aggtgcagct ggtcgagtct      780

ggaggaggat tggtgcagcc tggagggtca ttgaaactct catgtgcagc ctctggattc      840

accttcaata agtacgccat gaactgggtc cgccaggctc caggaaaggg tttggaatgg      900

gttgctcgca taagaagtaa atataataat tatgcaacat attatgccga ttcagtgaaa      960

gacaggttca ccatctccag agatgattca aaaaacactg cctatctaca aatgaacaac     1020

ttgaaaactg aggacactgc cgtgtactac tgtgtgagac atgggaactt cggtaatagc     1080

tacatatcct actgggctta ctggggccaa gggactctgg tcaccgtctc ctcaggtggt     1140

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc agactgttgt gactcaggaa     1200

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1260

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1320

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1380

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1440

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1500

gtccta                                                                1506


<210>  281
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-VH

<400>  281

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  282
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-HCDR1

<400>  282

Asp Tyr Tyr Met Tyr 
1               5   


<210>  283
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-HCDR2

<400>  283

Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  284
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-HCDR3

<400>  284

Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu 
1               5                   10          


<210>  285
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM83A12-VH

<400>  285
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca atgccaagaa cagcctgtac      240

ctgcagacga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgacctc tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  286
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-VL

<400>  286

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  287
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-LCDR1

<400>  287

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  288
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-LCDR2

<400>  288

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  289
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-LCDR3

<400>  289

Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  290
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM83A12-VL

<400>  290
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gcctcctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacgactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  291
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-VH-VL

<400>  291

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  292
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM83A12-VH-VL

<400>  292
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca atgccaagaa cagcctgtac      240

ctgcagacga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgacctc tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcaag      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc ctcctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta cgactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  293
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM83A12-VH-VL x I2C VH-VL

<400>  293

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  294
<211>  1494
<212>  DNA
<213>  artificial

<220>
<223>  PM83A12-VH-VL x I2C VH-VL

<400>  294
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca atgccaagaa cagcctgtac      240

ctgcagacga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgacctc tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcaag      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc ctcctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta cgactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt ccta           1494


<210>  295
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-VH

<400>  295

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  296
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-HCDR1

<400>  296

Asp Tyr Tyr Met Tyr 
1               5   


<210>  297
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-HCDR2

<400>  297

Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  298
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-HCDR3

<400>  298

Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu 
1               5                   10          


<210>  299
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8MPF-VH

<400>  299
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg gactggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagacga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgacctc tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  300
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-VL

<400>  300

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  301
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-LCDR1

<400>  301

Arg Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  302
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-LCDR2

<400>  302

Ala Arg Thr Ile Phe Ile Cys Ile Ala Leu Ser Ala Thr Tyr Arg Tyr 
1               5                   10                  15      


Ser 
    


<210>  303
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-LCDR3

<400>  303

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  304
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8MPF-VL

<400>  304
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca gggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gccacctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacaactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  305
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-VH-VL

<400>  305

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  306
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8MPF-VH-VL

<400>  306
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg gactggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagacga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgacctc tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  307
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8MPF-VH-VL x I2C VH-VL

<400>  307

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  308
<211>  1494
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8MPF-VH-VL x I2C VH-VL

<400>  308
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg gactggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagacga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgacctc tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt ccta           1494


<210>  309
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-VH

<400>  309

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  310
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-HCDR1

<400>  310

Asp Tyr Tyr Met Ser 
1               5   


<210>  311
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-HCDR2

<400>  311

Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  312
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-HCDR3

<400>  312

Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr 
1               5                   10          


<210>  313
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L1-VH

<400>  313
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  314
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-VL

<400>  314

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  315
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-LCDR1

<400>  315

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  316
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-LCDR2

<400>  316

Ser Ala Thr Tyr Arg Tyr Ser 
1               5           


<210>  317
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-LCDR3

<400>  317

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  318
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L1-VL

<400>  318
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gccacctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacaactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  319
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-VH-VL

<400>  319

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  320
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L1-VH-VL

<400>  320
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcaag      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  321
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L1-VH-VL x I2C VH-VL

<400>  321

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  322
<211>  1493
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L1-VH-VL x I2C VH-VL

<400>  322
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcaag      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt cct            1493


<210>  323
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-VH

<400>  323

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  324
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-HCDR1

<400>  324

Asp Tyr Tyr Met Ser 
1               5   


<210>  325
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-HCDR2

<400>  325

Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  326
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-HCDR3

<400>  326

Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr 
1               5                   10          


<210>  327
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L2-VH

<400>  327
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  328
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-VL

<400>  328

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  329
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-LCDR1

<400>  329

Arg Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  330
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-LCDR2

<400>  330

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  331
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-LCDR3

<400>  331

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  332
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L2-VL

<400>  332
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca gggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gcctcctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacaactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  333
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-VH-VL

<400>  333

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  334
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L2-VH-VL

<400>  334
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc ctcctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  335
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L2-VH-VL x I2C VH-VL

<400>  335

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  336
<211>  1493
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L2-VH-VL x I2C VH-VL

<400>  336
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc ctcctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt cct            1493


<210>  337
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-VH

<400>  337

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  338
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-HCDR1

<400>  338

Asp Tyr Tyr Met Ser 
1               5   


<210>  339
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-HCDR2

<400>  339

Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  340
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-HCDR3

<400>  340

Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr 
1               5                   10          


<210>  341
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L3-VH

<400>  341
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  342
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-VL

<400>  342

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  343
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-LCDR1

<400>  343

Arg Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  344
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-LCDR2

<400>  344

Ser Ala Thr Tyr Arg Tyr Ser 
1               5           


<210>  345
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-LCDR3

<400>  345

Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  346
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L3-VL

<400>  346
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca gggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gccacctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacgactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  347
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-VH-VL

<400>  347

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  348
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L3-VH-VL

<400>  348
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta cgactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  349
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8L3-VH-VL x I2C VH-VL

<400>  349

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  350
<211>  1494
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8L3-VH-VL x I2C VH-VL

<400>  350
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta cgactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt ccta           1494


<210>  351
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-VH

<400>  351

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  352
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-HCDR1

<400>  352

Asp Tyr Tyr Met Tyr 
1               5   


<210>  353
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-HCDR2

<400>  353

Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  354
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-HCDR3

<400>  354

Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr 
1               5                   10          


<210>  355
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H3-VH

<400>  355
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc catggattac tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  356
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-VL

<400>  356

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  357
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-LCDR1

<400>  357

Arg Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  358
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-LCDR1

<400>  358

Ser Ala Thr Tyr Arg Tyr Ser 
1               5           


<210>  359
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-LCDR1

<400>  359

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  360
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H3-VL

<400>  360
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca gggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gccacctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacaactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  361
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-VH-VL

<400>  361

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  362
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H3-VH-VL

<400>  362
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc catggattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  363
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H3-VH-VL x I2C VH-VL

<400>  363

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Ser Asn Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  364
<211>  1493
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H3-VH-VL x I2C VH-VL

<400>  364
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggcctcc atctccgacg gcggctccaa cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc catggattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt cct            1493


<210>  365
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-VH

<400>  365

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  366
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-HCDR1

<400>  366

Asp Tyr Tyr Met Tyr 
1               5   


<210>  367
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-HCDR2

<400>  367

Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  368
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-HCDR3

<400>  368

Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr 
1               5                   10          


<210>  369
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H2-VH

<400>  369
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  370
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-VL

<400>  370

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Tyr Ser Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  371
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-LCDR1

<400>  371

Arg Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  372
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-LCDR2

<400>  372

Ser Ala Thr Tyr Arg Tyr Ser 
1               5           


<210>  373
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-LCDR3

<400>  373

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  374
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H2-VL

<400>  374
gacatccaga tgacccagtc ccccagctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca gggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagccc      120

ggccaggccc ctaagtccct gatctactcc gccacctacc ggtactctga cgtgccttcc      180

cggttctccg gctccgcgtc cggcaccgac ttcaccctga ccatctccag cgtgcagtct      240

gaggacttcg ccacgtacta ctgccagcag tacaactcct acccttacac cttcggcgga      300

gggaccaagc tggaaatcaa g                                                321


<210>  375
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-VH-VL

<400>  375

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  376
<211>  729
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H2-VH-VL

<400>  376
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaag                                                              729


<210>  377
<211>  498
<212>  PRT
<213>  artificial

<220>
<223>  PM07F8H2-VH-VL x I2C VH-VL

<400>  377

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Thr Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu 
        


<210>  378
<211>  1494
<212>  DNA
<213>  artificial

<220>
<223>  PM07F8H2-VH-VL x I2C VH-V

<400>  378
caggtgcagc tggtcgagtc tggcggcgga ctggtgaagc ctggcgagtc cctgaggctg       60

tcctgtgccg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggcc      120

cctgggaagg ggctggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tcccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc ccggggcttc      300

cctctgctga gacacggcgc cttcgattac tggggccagg gcaccctggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga catccagatg      420

acccagtccc ccagctccct gtccgcctcc gtgggcgaca gagtgaccat cacctgcagg      480

gcctcccaga acgtggacac caacgtggcc tggtatcagc agaagcccgg ccaggcccct      540

aagtccctga tctactccgc cacctaccgg tactctgacg tgccttcccg gttctccggc      600

tccgcgtccg gcaccgactt caccctgacc atctccagcg tgcagtctga ggacttcgcc      660

acgtactact gccagcagta caactcctac ccttacacct tcggcggagg gaccaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catatcctac     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt ccta           1494


<210>  379
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-VH

<400>  379

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  380
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-HCDR1

<400>  380

Asp Thr Tyr Met Asp 
1               5   


<210>  381
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-HCDR2

<400>  381

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  382
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-HCDR3

<400>  382

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  383
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5A5-VH

<400>  383
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  384
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-VL

<400>  384

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  385
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-LCDR1

<400>  385

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  386
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-LCDR2

<400>  386

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  387
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-LCDR3

<400>  387

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  388
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH5A5-VL

<400>  388
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gaaggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gattacactc tcacaattag caggctggag      240

cctgaagatg ttgccactta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  389
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-VH-VL

<400>  389

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  390
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH5A5-VH-VL

<400>  390
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag aaggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg attacactct cacaattagc aggctggagc ctgaagatgt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  391
<211>  497
<212>  PRT
<213>  artificial

<220>
<223>  PMH5A5-VH-VL x I2C VH-VL

<400>  391

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
    290                 295                 300                 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                325                 330                 335     


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
            340                 345                 350         


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
385                 390                 395                 400 


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                405                 410                 415     


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
        435                 440                 445             


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
    450                 455                 460                 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
465                 470                 475                 480 


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                485                 490                 495     


Leu 
    


<210>  392
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH5A5-VH-VL x I2C VH-VL

<400>  392
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag aaggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg attacactct cacaattagc aggctggagc ctgaagatgt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  393
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-VH

<400>  393

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  394
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-HCDR1

<400>  394

Asp Thr Tyr Met Asp 
1               5   


<210>  395
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-HCDR2

<400>  395

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  396
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-HCDR3

<400>  396

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  397
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8A5-VH

<400>  397
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  398
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-VL

<400>  398

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  399
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-LCDR1

<400>  399

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  400
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-LCDR2

<400>  400

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  401
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-LCDR3

<400>  401

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  402
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8A5-VL

<400>  402
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gaaggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gattacactc tcacaattag caggctggag      240

cctgaagatg ttgccactta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  403
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-VH-VL

<400>  403

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  404
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8A5-VH-VL

<400>  404
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag aaggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg attacactct cacaattagc aggctggagc ctgaagatgt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  405
<211>  497
<212>  PRT
<213>  artificial

<220>
<223>  PMH8A5-VH-VL x I2C VH-VL

<400>  405

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
    290                 295                 300                 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                325                 330                 335     


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
            340                 345                 350         


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
385                 390                 395                 400 


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                405                 410                 415     


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
        435                 440                 445             


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
    450                 455                 460                 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
465                 470                 475                 480 


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                485                 490                 495     


Leu 
    


<210>  406
<211>  1487
<212>  DNA
<213>  artificial

<220>
<223>  PMH8A5-VH-VL x I2C VH-VL

<400>  406
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag aaggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg attacactct cacaattagc aggctggagc ctgaagatgt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtcct                   1487


<210>  407
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-VH

<400>  407

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  408
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-HCDR1

<400>  408

Asp Thr Tyr Met Asp 
1               5   


<210>  409
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-HCDR2

<400>  409

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  410
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-HCDR3

<400>  410

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  411
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5B1-VH

<400>  411
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  412
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-VL

<400>  412

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  413
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-LCDR1

<400>  413

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  414
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-LCDR2

<400>  414

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  415
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-LCDR3

<400>  415

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  416
<211>  324
<212>  DNA
<213>  artificial

<220>
<223> PMH5B1-VL

<400>  416
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggatggag      240

gctgaagatt ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  417
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-VH-VL

<400>  417

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Met Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  418
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH5B1-VH-VL

<400>  418
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggatggagg ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  419
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B1-VL x I2C VH-VL

<400>  419

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Met Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  420
<211>  1487
<212>  DNA
<213>  artificial

<220>
<223>  PMH5B1-VL x I2C VH-VL

<400>  420
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggatggagg ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtcct                   1487


<210>  421
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-VH

<400>  421

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  422
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-HCDR1

<400>  422

Asp Thr Tyr Met Asp 
1               5   


<210>  423
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-HCDR2

<400>  423

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  424
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-HCDR3

<400>  424

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  425
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B1-VH

<400>  425
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  426
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-VL

<400>  426

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  427
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-LCDR1

<400>  427

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  428
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-LCDR2

<400>  428

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  429
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-LCDR3

<400>  429

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  430
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B1-VL

<400>  430
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggatggag      240

gctgaagatt ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  431
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-VH-VL

<400>  431

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Met Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  432
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B1-VH-VL

<400>  432
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggatggagg ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  433
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B1-VH-VL x I2C VH-VL

<400>  433

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Met Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  434
<211>  1487
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B1-VH-VL x I2C VH-VL

<400>  434
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggatggagg ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtcct                   1487


<210>  435
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-VH

<400>  435

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  436
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-HCDR1

<400>  436

Asp Thr Tyr Met Asp 
1               5   


<210>  437
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-HCDR2

<400>  437

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  438
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-HCDR3

<400>  438

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  439
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5B45-VH

<400>  439
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  440
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-VL

<400>  440

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu Ala Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  441
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-LCDR1

<400>  441

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  442
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-LCDR2

<400>  442

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  443
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-LCDR3

<400>  443

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  444
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH5B45-VL

<400>  444
gagatcgtgc tcacccagtc tccaaccacc ctggctctat ctcccgggga gagggtcact       60

ctctcctgca gtgccagctc tagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

cctgaagatg ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  445
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-VH-VL

<400>  445

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  446
<211>  723
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-VH-VL

<400>  446

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly Gly Thr 
            20                  25                  30          


Thr Ala Ala Gly Ala Ala Gly Cys Cys Ala Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Cys Ala Ala Gly Gly Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Ala Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Ala Cys Thr Thr Thr Ala Ala Ala Gly Ala Cys Ala Cys Cys 
                85                  90                  95      


Thr Ala Thr Ala Thr Gly Gly Ala Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Cys Ala Gly Ala Cys Gly Cys Cys Thr Gly Ala Ala Cys Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Ala Gly Gly Ala Thr Thr Gly Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Cys Gly Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Gly Thr Ala Ala 
                165                 170                 175     


Ala Thr Ala Thr Gly Ala Cys Cys Cys Gly Ala Ala Ala Thr Thr Cys 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Gly Gly Gly Thr Cys Ala Cys Thr Ala 
        195                 200                 205             


Thr Ala Ala Cys Ala Gly Cys Ala Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Cys Ala Cys Cys Ala Ala Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Gly Ala Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr 
        275                 280                 285             


Gly Cys Thr Ala Gly Ala Gly Gly Cys Gly Gly Gly Ala Thr Gly Ala 
    290                 295                 300                 


Thr Ala Thr Gly Gly Thr Ala Cys Thr Thr Cys Gly Ala Thr Gly Thr 
305                 310                 315                 320 


Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys Cys 
                325                 330                 335     


Ala Cys Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr 
            340                 345                 350         


Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Thr Cys 
        355                 360                 365             


Thr Gly Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys Thr Cys Cys 
    370                 375                 380                 


Gly Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly 
385                 390                 395                 400 


Ala Gly Ala Thr Cys Gly Thr Gly Cys Thr Cys Ala Cys Cys Cys Ala 
                405                 410                 415     


Gly Thr Cys Thr Cys Cys Ala Ala Cys Cys Ala Cys Cys Cys Thr Gly 
            420                 425                 430         


Gly Cys Thr Cys Thr Ala Thr Cys Thr Cys Cys Cys Gly Gly Gly Gly 
        435                 440                 445             


Ala Gly Ala Gly Gly Gly Thr Cys Ala Cys Thr Cys Thr Cys Thr Cys 
    450                 455                 460                 


Cys Thr Gly Cys Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Cys Thr 
465                 470                 475                 480 


Ala Gly Thr Ala Thr Ala Ala Gly Thr Thr Cys Cys Ala Ala Thr Thr 
                485                 490                 495     


Ala Cys Thr Thr Gly Cys Ala Thr Thr Gly Gly Thr Ala Thr Cys Ala 
            500                 505                 510         


Gly Cys Ala Gly Ala Ala Gly Cys Cys Ala Gly Gly Ala Thr Thr Gly 
        515                 520                 525             


Cys Cys Cys Cys Cys Thr Ala Gly Ala Cys Thr Cys Thr Thr Gly Ala 
    530                 535                 540                 


Thr Thr Thr Ala Thr Ala Gly Gly Ala Cys Ala Thr Cys Cys Ala Ala 
545                 550                 555                 560 


Thr Cys Thr Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Ala Thr Cys 
                565                 570                 575     


Cys Cys Ala Gly Ala Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly 
            580                 585                 590         


Gly Cys Ala Gly Thr Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys 
        595                 600                 605             


Cys Gly Ala Thr Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Ala 
    610                 615                 620                 


Ala Thr Thr Ala Gly Cys Ala Gly Gly Cys Thr Gly Gly Ala Gly Cys 
625                 630                 635                 640 


Cys Thr Gly Ala Ala Gly Ala Thr Gly Thr Thr Gly Cys Cys Gly Thr 
                645                 650                 655     


Thr Thr Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly 
            660                 665                 670         


Gly Gly Thr Ala Gly Thr Ala Gly Thr Thr Thr Ala Cys Cys Gly Thr 
        675                 680                 685             


Ala Cys Ala Cys Gly Thr Thr Cys Gly Gly Ala Cys Ala Ala Gly Gly 
    690                 695                 700                 


Gly Ala Cys Cys Ala Ala Gly Cys Thr Thr Gly Ala Gly Ala Thr Cys 
705                 710                 715                 720 


Ala Ala Ala 
            


<210>  447
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH5B45-VH-VL x I2C VH-VL

<400>  447

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  448
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH5B45-VH-VL x I2C VH-VL

<400>  448
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccaaccaccc tggctctatc tcccggggag agggtcactc tctcctgcag tgccagctct      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  449
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-VH

<400>  449

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  450
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-HCDR1

<400>  450

Asp Thr Tyr Met Asp 
1               5   


<210>  451
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-HCDR2

<400>  451

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  452
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-HCDR3

<400>  452

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  453
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B4-VH

<400>  453
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  454
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-VL

<400>  454

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu Ala Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  455
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-LCDR1

<400>  455

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  456
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-LCDR2

<400>  456

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  457
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-LCDR3

<400>  457

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  458
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B4-VL

<400>  458
gagatcgtgc tcacccagtc tccaaccacc ctggctctat ctcccgggga gagggtcact       60

ctctcctgca gtgccagctc tagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

cctgaagatg ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  459
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-VH-VL

<400>  459

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  460
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B4-VH-VL

<400>  460
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccaaccaccc tggctctatc tcccggggag agggtcactc tctcctgcag tgccagctct      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  461
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8B4-VH-VL x I2C VH-VL

<400>  461

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  462
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8B4-VH-VL x I2C VH-VL

<400>  462
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccaaccaccc tggctctatc tcccggggag agggtcactc tctcctgcag tgccagctct      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  463
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-VH

<400>  463

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  464
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-HCDR1

<400>  464

Asp Thr Tyr Met Asp 
1               5   


<210>  465
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-HCDR2

<400>  465

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  466
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-HCDR3

<400>  466

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  467
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5C2-VH

<400>  467
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  468
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-VL

<400>  468

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  469
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-LCDR1

<400>  469

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  470
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-LCDR2

<400>  470

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  471
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-LCDR3

<400>  471

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  472
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH5C2-VL

<400>  472
gagatcgtgc tcacccagtc tccagccacc ctgtctgtat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattat cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gctcgcttca gtggcagtgg gtctgggacc gctttcactc tcacaattag caggctggag      240

cctgaagatt ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  473
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-VH-VL

<400>  473

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Ser Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  474
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH5C2-VH-VL

<400>  474
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattatc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg ctttcactct cacaattagc aggctggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  475
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH5C2-VH-VL x I2C VH-VL

<400>  475

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Ser Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  476
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH5C2-VH-VL x I2C VH-VL

<400>  476
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattatc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg ctttcactct cacaattagc aggctggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  477
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-VH

<400>  477

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  478
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-HCDR1

<400>  478

Asp Thr Tyr Met Asp 
1               5   


<210>  479
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-HCDR2

<400>  479

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  480
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-HCDR3

<400>  480

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  481
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8C2-VH

<400>  481
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  482
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-VL

<400>  482

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  483
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-LCDR1

<400>  483

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  484
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-LCDR2

<400>  484

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  485
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-LCDR3

<400>  485

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  486
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8C2-VL

<400>  486
gagatcgtgc tcacccagtc tccagccacc ctgtctgtat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattat cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gctcgcttca gtggcagtgg gtctgggacc gctttcactc tcacaattag caggctggag      240

cctgaagatt ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  487
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-VH-VL

<400>  487

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Ser Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  488
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8C2-VH-VL

<400>  488
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattatc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg ctttcactct cacaattagc aggctggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  489
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8C2-VH-VL x I2C VH-VL

<400>  489

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Ser Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  490
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8C2-VH-VL x I2C VH-VL

<400>  490
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattatc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg ctttcactct cacaattagc aggctggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  491
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-VH

<400>  491

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  492
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-HCDR1

<400>  492

Asp Thr Tyr Met Asp 
1               5   


<210>  493
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-HCDR2

<400>  493

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  494
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-HCDR3

<400>  494

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  495
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5D1-VH

<400>  495
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  496
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-VL

<400>  496

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  497
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-LCDR1

<400>  497

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  498
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-LCDR2

<400>  498

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  499
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-LCDR3

<400>  499

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  500
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH5D1-VL

<400>  500
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattac cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gctcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

cctgaagatg ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  501
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-VH-VL

<400>  501

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  502
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH5D1-VH-VL

<400>  502
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattacc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  503
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH5D1-VH-VL x I2C VH-VL

<400>  503

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  504
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH5D1-VH-VL x I2C VH-VL

<400>  504
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattacc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  505
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-VH

<400>  505

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  506
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-HCDR1

<400>  506

Asp Thr Tyr Met Asp 
1               5   


<210>  507
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-HCDR2

<400>  507

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  508
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-HCDR3

<400>  508

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  509
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8D1-VH

<400>  509
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  510
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-VL

<400>  510

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  511
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-LCDR1

<400>  511

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  512
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-LCDR2

<400>  512

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  513
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-LCDR3

<400>  513

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  514
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8D1-VL

<400>  514
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattac cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gctcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

cctgaagatg ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  515
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-VH-VL

<400>  515

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  516
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8D1-VH-VL

<400>  516
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattacc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  517
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8D1-VH-VL x I2C VH-VL

<400>  517

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  518
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8D1-VH-VL x I2C VH-VL

<400>  518
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattacc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag ctcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  519
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-VH

<400>  519

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  520
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-HCDR1

<400>  520

Asp Thr Tyr Met Asp 
1               5   


<210>  521
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-HCDR2

<400>  521

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  522
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-HCDR3

<400>  522

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  523
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5E2-VH

<400>  523
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  524
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-VL

<400>  524

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  525
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-LCDR1

<400>  525

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  526
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-LCDR2

<400>  526

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  527
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-LCDR3

<400>  527

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  528
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH5E2-VL

<400>  528
gagatcgtgc tcacccagtc tccagccacc atgtctgtat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

gctgaagatt ttgccactta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  529
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-VH-VL

<400>  529

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  530
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH5E2-VH-VL

<400>  530
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagg ctgaagattt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  531
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH5E2-VH-VL c I2C VH-VL

<400>  531

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  532
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH5E2-VH-VL c I2C VH-VL

<400>  532
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagg ctgaagattt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  533
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-VH

<400>  533

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  534
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-HCDR1

<400>  534

Asp Thr Tyr Met Asp 
1               5   


<210>  535
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-HCDR2

<400>  535

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  536
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-HCDR3

<400>  536

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  537
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E2-VH

<400>  537
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  538
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-VL

<400>  538

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  539
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-LCDR1

<400>  539

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  540
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-LCDR2

<400>  540

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  541
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-LCDR3

<400>  541

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  542
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E2-VL

<400>  542
gagatcgtgc tcacccagtc tccagccacc atgtctgtat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

gctgaagatt ttgccactta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  543
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-VH-VL

<400>  543

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  544
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E2-VH-VL

<400>  544
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagg ctgaagattt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  545
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E2-VH-VL x I2C VH-VL

<400>  545

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  546
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E2-VH-VL x I2C VH-VL

<400>  546
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tgtctgtatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagg ctgaagattt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  547
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-VH

<400>  547

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  548
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-HCDR1

<400>  548

Asp Thr Tyr Met Asp 
1               5   


<210>  549
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-HCDR2

<400>  549

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  550
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-HCDR3

<400>  550

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  551
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E4-VH

<400>  551
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  552
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-VL

<400>  552

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  553
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-LCDR1

<400>  553

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  554
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-LCDR2

<400>  554

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  555
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-LCDR3

<400>  555

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  556
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E4-VL

<400>  556
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gattacactc tcacaattag caggctggag      240

cctgaagatt ttgccactta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  557
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-VH-VL

<400>  557

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  558
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E4-VH-VL

<400>  558
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg attacactct cacaattagc aggctggagc ctgaagattt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  559
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8E4-VH-VL x I2C VH-VL

<400>  559

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  560
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8E4-VH-VL x I2C VH-VL

<400>  560
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg attacactct cacaattagc aggctggagc ctgaagattt tgccacttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  561
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-VH

<400>  561

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  562
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-HCDR1

<400>  562

Asp Thr Tyr Met Asp 
1               5   


<210>  563
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-HCDR2

<400>  563

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  564
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-HCDR3

<400>  564

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  565
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8G6-VH

<400>  565
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  566
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-VL

<400>  566

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  567
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-LCDR1

<400>  567

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  568
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-LCDR2

<400>  568

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  569
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-LCDR3

<400>  569

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  570
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8G6-VL

<400>  570
gagatcgtgc tcacccagtc tccagccacc atgtctctat ctcccgggga gagggccact       60

atctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctaaact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggatggag      240

cctgaagatt ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  571
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-VH-VL

<400>  571

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Ile Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Lys Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Met Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  572
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8G6-VH-VL

<400>  572
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tgtctctatc tcccggggag agggccacta tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctaaactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggatggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  573
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8G6-VH-VL x I2C VH-VL

<400>  573

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Ile Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Lys Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Met Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  574
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8G6-VH-VL x I2C VH-VL

<400>  574
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tgtctctatc tcccggggag agggccacta tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctaaactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggatggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  575
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-VH

<400>  575

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  576
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-HCDR1

<400>  576

Asp Thr Tyr Met Asp 
1               5   


<210>  577
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-HCDR2

<400>  577

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  578
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-HCDR3

<400>  578

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  579
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH5H2-VH

<400>  579
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  580
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-VL

<400>  580

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ala Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  581
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-LCDR1

<400>  581

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  582
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-LCDR2

<400>  582

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  583
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-LCDR3

<400>  583

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  584
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH5H2-VL

<400>  584
gagatcgtgc tcacccagtc tccagccacc atggctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

cctgaagatg ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  585
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-VH-VL

<400>  585

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  586
<211>  723
<212>  DNA
<213>  PMH5H2-VH-VL

<400>  586
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tggctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  587
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH5H2-VH-VL x I2C VH-VL

<400>  587

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Lys Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  588
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH5H2-VH-VL x I2C VH-VL

<400>  588
caggtgcagc tggtccagtc tggggcagag gttaagaagc caggggcctc agtcaaggtg       60

tcctgcaaag cttctggcta caactttaaa gacacctata tggactgggt gaagcagacg      120

cctgaacagg gcctggaatg gatgggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggtcactata acagcagaca catccaccaa cacagcctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tggctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  589
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-VH

<400>  589

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  590
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-HCDR1

<400>  590

Asp Thr Tyr Met Asp 
1               5   


<210>  591
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-HCDR2

<400>  591

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
  

<210>  592
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-HCDR3

<400>  592

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  593
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H2-VH

<400>  593
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  594
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-VL

<400>  594

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ala Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  595
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-LCDR1

<400>  595

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  596
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-LCDR2

<400>  596

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  597
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-LCDR3

<400>  597

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  598
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H2-VL

<400>  598
gagatcgtgc tcacccagtc tccagccacc atggctctat ctcccgggga gagggccact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattgc cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattag caggctggag      240

cctgaagatg ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  599
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-VH-VL

<400>  599

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  600
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H2-VH-VL

<400>  600
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tggctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  601
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H2-VH-VL x I2C VH-VL

<400>  601

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met 
    130                 135                 140                 


Ala Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  602
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H2-VH-VL x I2C VH-VL

<400>  602
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccacca tggctctatc tcccggggag agggccactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattgcc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattagc aggctggagc ctgaagatgt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  603
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-VH

<400>  603

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  604
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-HCDR1

<400>  604

Asp Thr Tyr Met Asp 
1               5   


<210>  605
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-HCDR2

<400>  605

Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  606
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-HCDR3

<400>  606

Gly Gly Met Ile Trp Tyr Phe Asp Val 
1               5                   


<210>  607
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H3-VH

<400>  607
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  608
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-VL

<400>  608

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ile Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Thr Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ser Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  609
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-LCDR1

<400>  609

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  610
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-LCDR2

<400>  610

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  611
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-LCDR3

<400>  611

Gln Gln Gly Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  612
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H3-VL

<400>  612
gagatcgtgc tcacccagtc tccagccacc ctgtctctat ctcccgggga gaggatcact       60

ctctcctgca gtgccagctc aagtataagt tccaattact tgcattggta tcagcagaag      120

ccaggattac cccctagact cttgatttat aggacatcca atctggcttc tggaatccca      180

gatcgcttca gtggcagtgg gtctgggacc gatttcactc tcacaattgg cacgctggag      240

cctgaagatt ttgccgttta ctactgccag cagggtagta gtttaccgta cacgttcgga      300

caagggacca agcttgagat caaa                                             324


<210>  613
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-VH-VL

<400>  613

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ile Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Gly Thr Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  614
<211>  723
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H3-VH-VL

<400>  614
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag aggatcactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattacc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattggc acgctggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaa                                                                    723


<210>  615
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  PMH8H3-VH-VL x I2C VH-VL

<400>  615

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Thr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Ser Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Pro Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Ile Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ile Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Leu 
                165                 170                 175     


Pro Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Gly Thr Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Gly Ser Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
    290                 295                 300                 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                325                 330                 335     


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
            340                 345                 350         


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
385                 390                 395                 400 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                405                 410                 415     


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
            420                 425                 430         


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
    450                 455                 460                 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
465                 470                 475                 480 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495     


<210>  616
<211>  1488
<212>  DNA
<213>  artificial

<220>
<223>  PMH8H3-VH-VL x I2C VH-VL

<400>  616
caggtgcagc tggtccagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caccattaca gacacctata tggactgggt gaggcaggcg      120

cctggacagg gcctggaatg gattggaagg attgatcctg cgaatggtga tagtaaatat      180

gacccgaaat tccagggcag ggccactata acaccagaca catccaccaa cacagtctac      240

atggagctca gcagcctgag atctgaggac actgccgtct attattgtgc tagaggcggg      300

atgatatggt acttcgatgt ctggggccaa gggaccacgg tcaccgtctc ctcaggtggt      360

ggtggttctg gcggcggcgg ctccggtggt ggtggttctg agatcgtgct cacccagtct      420

ccagccaccc tgtctctatc tcccggggag aggatcactc tctcctgcag tgccagctca      480

agtataagtt ccaattactt gcattggtat cagcagaagc caggattacc ccctagactc      540

ttgatttata ggacatccaa tctggcttct ggaatcccag atcgcttcag tggcagtggg      600

tctgggaccg atttcactct cacaattggc acgctggagc ctgaagattt tgccgtttac      660

tactgccagc agggtagtag tttaccgtac acgttcggac aagggaccaa gcttgagatc      720

aaatccggag gtggtggatc cgaggtgcag ctggtcgagt ctggaggagg attggtgcag      780

cctggagggt cattgaaact ctcatgtgca gcctctggat tcaccttcaa taagtacgcc      840

atgaactggg tccgccaggc tccaggaaag ggtttggaat gggttgctcg cataagaagt      900

aaatataata attatgcaac atattatgcc gattcagtga aagacaggtt caccatctcc      960

agagatgatt caaaaaacac tgcctatcta caaatgaaca acttgaaaac tgaggacact     1020

gccgtgtact actgtgtgag acatgggaac ttcggtaata gctacatatc ctactgggct     1080

tactggggcc aagggactct ggtcaccgtc tcctcaggtg gtggtggttc tggcggcggc     1140

ggctccggtg gtggtggttc tcagactgtt gtgactcagg aaccttcact caccgtatca     1200

cctggtggaa cagtcacact cacttgtggc tcctcgactg gggctgttac atctggcaac     1260

tacccaaact gggtccaaca aaaaccaggt caggcacccc gtggtctaat aggtgggact     1320

aagttcctcg cccccggtac tcctgccaga ttctcaggct ccctgcttgg aggcaaggct     1380

gccctcaccc tctcaggggt acagccagag gatgaggcag aatattactg tgttctatgg     1440

tacagcaacc gctgggtgtt cggtggagga accaaactga ctgtccta                  1488


<210>  617
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-VH

<400>  617

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  618
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-HCDR1

<400>  618

Tyr Phe Asp Ile Asn 
1               5   


<210>  619
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-HCDR2

<400>  619

Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  620
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-HCDR3

<400>  620

Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser 
1               5                   10      


<210>  621
<211>  360
<212>  DNA
<213>  artificial

<220>
<223>  PM74G3-VH

<400>  621
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcaggcg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accatagaca cgtccagctc caccgcctac      240

atcgagctgt cccggctgac atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtgac cgtctcctca      360


<210>  622
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-VL

<400>  622

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  623
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-LCDR1

<400>  623

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  624
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-LCDR2

<400>  624

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  625
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-LCDR3

<400>  625

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  626
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  PM74G3-VL

<400>  626
gacgtcgtga tgacccagac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tacacgttcg gaggggggac caagcttgag atcaaa                                336


<210>  627
<211>  247
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-VH-VL

<400>  627

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  628
<211>  741
<212>  DNA
<213>  artificial

<220>
<223>  PM74G3-VH-VL

<400>  628
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcaggcg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accatagaca cgtccagctc caccgcctac      240

atcgagctgt cccggctgac atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtgac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgacc      420

cagactccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      480

agtcagagcc ttgtacacag taatggaaac acctatttac attggtacct gcagaagcca      540

ggccagtctc caaagctcct gatctacaaa gtttccaacc gattttctgg ggtcccagac      600

aggttcagtg gcagtggatc agggacagat ttcacactca agatcagcag agtggaggct      660

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttccgtacac gttcggaggg      720

gggaccaagc ttgagatcaa a                                                741


<210>  629
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  PM74G3-VH-VL x I2C VH-VL

<400>  629

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         


Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
385                 390                 395                 400 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                405                 410                 415     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        435                 440                 445             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    450                 455                 460                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Thr Val Leu 
            500         


<210>  630
<211>  1506
<212>  DNA
<213>  artificial

<220>
<223>  PM74G3-VH-VL x I2C VH-VL

<400>  630
caggtgcagc tggtccagtc tggcgccgaa gtgaagaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tacttcgaca tcaactgggt gcggcaggcg      120

cctgagcagg gcctggaatg gatgggcggc atctcccctg gcgacggcaa caccaactac      180

aacgagaact tcaagggcag ggtcacaatg accatagaca cgtccagctc caccgcctac      240

atcgagctgt cccggctgac atctgacgac accgccgtgt actactgcgc cagggacggc      300

aacttccctt actacgccat ggactcttgg ggccagggca ccacggtgac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacgt cgtgatgacc      420

cagactccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      480

agtcagagcc ttgtacacag taatggaaac acctatttac attggtacct gcagaagcca      540

ggccagtctc caaagctcct gatctacaaa gtttccaacc gattttctgg ggtcccagac      600

aggttcagtg gcagtggatc agggacagat ttcacactca agatcagcag agtggaggct      660

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttccgtacac gttcggaggg      720

gggaccaagc ttgagatcaa atccggaggt ggtggatccg aggtgcagct ggtcgagtct      780

ggaggaggat tggtgcagcc tggagggtca ttgaaactct catgtgcagc ctctggattc      840

accttcaata agtacgccat gaactgggtc cgccaggctc caggaaaggg tttggaatgg      900

gttgctcgca taagaagtaa atataataat tatgcaacat attatgccga ttcagtgaaa      960

gacaggttca ccatctccag agatgattca aaaaacactg cctatctaca aatgaacaac     1020

ttgaaaactg aggacactgc cgtgtactac tgtgtgagac atgggaactt cggtaatagc     1080

tacatatcct actgggctta ctggggccaa gggactctgg tcaccgtctc ctcaggtggt     1140

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc agactgttgt gactcaggaa     1200

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1260

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1320

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1380

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1440

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1500

gtccta                                                                1506


<210>  631
<211>  27
<212>  PRT
<213>  Macaca fascicularis

<400>  631

Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr Gln 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Ile Leu Thr Cys 
            20                  25          


<210>  632
<211>  27
<212>  PRT
<213>  Macaca fascicularis

<400>  632

Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr Gln 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
            20                  25          


<210>  633
<211>  27
<212>  PRT
<213>  Macaca mulatta

<400>  633

Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr His 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
            20                  25          


